 Wonkyu Ju
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| Title | Associate Adjunct Professor |
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| Institution | University of California San Diego |
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| Department | Ophthalmology |
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| Address | 9500 Gilman Drive #0946
La Jolla CA 92093
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| Phone | 858-246-0452 |
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| vCard | Download vCard |
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 Research Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Ju WK, Shim MS, Kim KY, Bu JH, Park TL, Ahn S, Weinreb RN. Ubiquinol promotes retinal ganglion cell survival and blocks the apoptotic pathway in ischemic retinal degeneration. Biochem Biophys Res Commun. 2018 Aug 11. PMID: 30107910.
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Shim MS, Kim KY, Noh M, Ko JY, Ahn S, An MA, Iwata T, Perkins GA, Weinreb RN, Ju WK. Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line. Biochem Biophys Res Commun. 2018 Aug 09. PMID: 30100066.
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Shim MS, Kim KY, Bu JH, Nam HS, Jeong SW, Park TL, Ellisman MH, Weinreb RN, Ju WK. Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. Cell Death Dis. 2018 Feb 19; 9(3):285. PMID: 29459737.
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Shim MS, Kim KY, Ju WK. Role of cyclic AMP in the eye with glaucoma. BMB Rep. 2017 Feb; 50(2):60-70. PMID: 27916026.
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Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK. Corrigendum: Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2017 Jan 19; 7:40460. PMID: 28102236.
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Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK. Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2016 Sep 22; 6:33830. PMID: 27654856.
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Ju WK, Kim KY, Noh YH, Hoshijima M, Lukas TJ, Ellisman MH, Weinreb RN, Perkins GA. Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia. 2015 May; 63(5):736-53. PMID: 25557093; PMCID: PMC4373968.
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Lee D, Kim KY, Shim MS, Kim SY, Ellisman MH, Weinreb RN, Ju WK. Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury. Apoptosis. 2014 Apr; 19(4):603-14. PMID: 24337820; PMCID: PMC3938850.
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Lee D, Shim MS, Kim KY, Noh YH, Kim H, Kim SY, Weinreb RN, Ju WK. Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2014 Feb 18; 55(2):993-1005. PMID: 24458150; PMCID: PMC3929080.
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Lee D, Kim KY, Noh YH, Chai S, Lindsey JD, Ellisman MH, Weinreb RN, Ju WK. Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury. PLoS One. 2012; 7(10):e47098. PMID: 23056591; PMCID: PMC3467218.
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Park SW, Kim KY, Lindsey JD, Dai Y, Heo H, Nguyen DH, Ellisman MH, Weinreb RN, Ju WK. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2837-43. PMID: 21372007; PMCID: PMC3088566.
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Dai Y, Weinreb RN, Kim KY, Nguyen D, Park S, Sun X, Lindsey JD, Ellisman MH, Ju WK. Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. Invest Ophthalmol Vis Sci. 2011 Apr 16; 52(5):2468-76. PMID: 21220562; PMCID: PMC3088543.
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Ju WK, Kim KY. Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay. Methods Mol Biol. 2011; 740:149-56. PMID: 21468976; PMCID: PMC4104946.
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Ju WK, Kim KY, Duong-Polk KX, Lindsey JD, Ellisman MH, Weinreb RN. Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma. Mol Vis. 2010 Jul 15; 16:1331-42. PMID: 20664796; PMCID: PMC2905637.
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Van Bergen NJ, Wood JP, Chidlow G, Trounce IA, Casson RJ, Ju WK, Weinreb RN, Crowston JG. Recharacterization of the RGC-5 retinal ganglion cell line. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4267-72. PMID: 19443730.
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Ju WK, Kim KY, Lindsey JD, Angert M, Patel A, Scott RT, Liu Q, Crowston JG, Ellisman MH, Perkins GA, Weinreb RN. Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis. 2009; 15:120-34. PMID: 19169378; PMCID: PMC2629709.
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Ju WK, Lindsey JD, Angert M, Patel A, Weinreb RN. Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina. Mol Vis. 2008; 14:2629-38. PMID: 19122832; PMCID: PMC2613079.
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Ju WK, Kim KY, Angert M, Duong-Polk KX, Lindsey JD, Ellisman MH, Weinreb RN. Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):707-16. PMID: 18936150; PMCID: PMC2678967.
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Ju WK, Kim KY, Lindsey JD, Angert M, Duong-Polk KX, Scott RT, Kim JJ, Kukhmazov I, Ellisman MH, Perkins GA, Weinreb RN. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4903-11. PMID: 18469184; PMCID: PMC2688012.
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Leung CK, Lindsey JD, Crowston JG, Ju WK, Liu Q, Bartsch DU, Weinreb RN. In vivo imaging of murine retinal ganglion cells. J Neurosci Methods. 2008 Mar 15; 168(2):475-8. PMID: 18079000.
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Liu Q, Ju WK, Crowston JG, Xie F, Perry G, Smith MA, Lindsey JD, Weinreb RN. Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4580-9. PMID: 17898281.
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Ju WK, Liu Q, Kim KY, Crowston JG, Lindsey JD, Agarwal N, Ellisman MH, Perkins GA, Weinreb RN. Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2145-51. PMID: 17460273.
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Ju WK, Misaka T, Kushnareva Y, Nakagomi S, Agarwal N, Kubo Y, Lipton SA, Bossy-Wetzel E. OPA1 expression in the normal rat retina and optic nerve. J Comp Neurol. 2005 Jul 18; 488(1):1-10. PMID: 15912498; PMCID: PMC1350956.
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Kim KY, Ju WK, Neufeld AH. Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia. Neurobiol Aging. 2004 Apr; 25(4):491-500. PMID: 15013570.
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Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage. 2003 Nov; 20(3):1714-22. PMID: 14642481.
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Ju WK, Kim KY, Neufeld AH. Increased activity of cyclooxygenase-2 signals early neurodegenerative events in the rat retina following transient ischemia. Exp Eye Res. 2003 Aug; 77(2):137-45. PMID: 12873443.
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Ju WK, Neufeld AH. Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J Comp Neurol. 2002 Oct 28; 452(4):392-9. PMID: 12355421.
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Ju WK, Gwon JS, Park SJ, Kim KY, Moon JI, Lee MY, Oh SJ, Chun MH. Growth-associated protein 43 is up-regulated in the ganglion cells of the ischemic rat retina. Neuroreport. 2002 May 07; 13(6):861-5. PMID: 11997702.
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