Loading...

Wonkyu Ju

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentOphthalmology
Address9500 Gilman Drive #0946
La Jolla CA 92093
Phone858-246-0452
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Mitochondrial Dysfunction in Glaucomatous Optic Neuropathy
    NIH/NEI R01EY018658Dec 1, 2007 - Aug 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Shim MS, Kim KY, Bu JH, Nam HS, Jeong SW, Park TL, Ellisman MH, Weinreb RN, Ju W. Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. Cell Death Dis. 2018 Feb 19; 9(3):285. PMID: 29459737.
      View in: PubMed
    2. Shim MS, Kim KY, Ju W. Role of cyclic AMP in the eye with glaucoma. BMB Rep. 2017 Feb; 50(2):60-70. PMID: 27916026.
      View in: PubMed
    3. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju W. Corrigendum: Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2017 Jan 19; 7:40460. PMID: 28102236.
      View in: PubMed
    4. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju W. Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2016 Sep 22; 6:33830. PMID: 27654856.
      View in: PubMed
    5. Ju W, Kim KY, Noh YH, Hoshijima M, Lukas TJ, Ellisman MH, Weinreb RN, Perkins GA. Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia. 2015 May; 63(5):736-53. PMID: 25557093; PMCID: PMC4373968.
      View in: PubMed, PubMed Central
    6. Lee D, Kim KY, Shim MS, Kim SY, Ellisman MH, Weinreb RN, Ju W. Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury. Apoptosis. 2014 Apr; 19(4):603-14. PMID: 24337820; PMCID: PMC3938850.
      View in: PubMed, PubMed Central
    7. Lee D, Shim MS, Kim KY, Noh YH, Kim H, Kim SY, Weinreb RN, Ju W. Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2014 Feb 18; 55(2):993-1005. PMID: 24458150; PMCID: PMC3929080.
      View in: PubMed, PubMed Central
    8. Lee D, Kim KY, Noh YH, Chai S, Lindsey JD, Ellisman MH, Weinreb RN, Ju W. Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury. PLoS One. 2012; 7(10):e47098. PMID: 23056591; PMCID: PMC3467218.
      View in: PubMed, PubMed Central
    9. Park SW, Kim KY, Lindsey JD, Dai Y, Heo H, Nguyen DH, Ellisman MH, Weinreb RN, Ju W. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2837-43. PMID: 21372007; PMCID: PMC3088566.
      View in: PubMed, PubMed Central
    10. Dai Y, Weinreb RN, Kim KY, Nguyen D, Park S, Sun X, Lindsey JD, Ellisman MH, Ju W. Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. Invest Ophthalmol Vis Sci. 2011 Apr 16; 52(5):2468-76. PMID: 21220562; PMCID: PMC3088543.
      View in: PubMed, PubMed Central
    11. Ju W, Kim KY. Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay. Methods Mol Biol. 2011; 740:149-56. PMID: 21468976; PMCID: PMC4104946.
      View in: PubMed, PubMed Central
    12. Ju W, Kim KY, Duong-Polk KX, Lindsey JD, Ellisman MH, Weinreb RN. Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma. Mol Vis. 2010 Jul 15; 16:1331-42. PMID: 20664796; PMCID: PMC2905637.
      View in: PubMed, PubMed Central
    13. Van Bergen NJ, Wood JP, Chidlow G, Trounce IA, Casson RJ, Ju W, Weinreb RN, Crowston JG. Recharacterization of the RGC-5 retinal ganglion cell line. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4267-72. PMID: 19443730.
      View in: PubMed
    14. Ju W, Kim KY, Lindsey JD, Angert M, Patel A, Scott RT, Liu Q, Crowston JG, Ellisman MH, Perkins GA, Weinreb RN. Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis. 2009; 15:120-34. PMID: 19169378; PMCID: PMC2629709.
      View in: PubMed, PubMed Central
    15. Ju W, Lindsey JD, Angert M, Patel A, Weinreb RN. Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina. Mol Vis. 2008; 14:2629-38. PMID: 19122832; PMCID: PMC2613079.
      View in: PubMed, PubMed Central
    16. Ju W, Kim KY, Angert M, Duong-Polk KX, Lindsey JD, Ellisman MH, Weinreb RN. Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):707-16. PMID: 18936150; PMCID: PMC2678967.
      View in: PubMed, PubMed Central
    17. Ju W, Kim KY, Lindsey JD, Angert M, Duong-Polk KX, Scott RT, Kim JJ, Kukhmazov I, Ellisman MH, Perkins GA, Weinreb RN. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4903-11. PMID: 18469184; PMCID: PMC2688012.
      View in: PubMed, PubMed Central
    18. Leung CK, Lindsey JD, Crowston JG, Ju W, Liu Q, Bartsch DU, Weinreb RN. In vivo imaging of murine retinal ganglion cells. J Neurosci Methods. 2008 Mar 15; 168(2):475-8. PMID: 18079000.
      View in: PubMed
    19. Liu Q, Ju W, Crowston JG, Xie F, Perry G, Smith MA, Lindsey JD, Weinreb RN. Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4580-9. PMID: 17898281.
      View in: PubMed
    20. Ju W, Liu Q, Kim KY, Crowston JG, Lindsey JD, Agarwal N, Ellisman MH, Perkins GA, Weinreb RN. Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2145-51. PMID: 17460273.
      View in: PubMed
    21. Ju W, Misaka T, Kushnareva Y, Nakagomi S, Agarwal N, Kubo Y, Lipton SA, Bossy-Wetzel E. OPA1 expression in the normal rat retina and optic nerve. J Comp Neurol. 2005 Jul 18; 488(1):1-10. PMID: 15912498; PMCID: PMC1350956.
      View in: PubMed, PubMed Central
    22. Kim KY, Ju W, Neufeld AH. Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia. Neurobiol Aging. 2004 Apr; 25(4):491-500. PMID: 15013570.
      View in: PubMed
    23. Song SK, Sun SW, Ju W, Lin SJ, Cross AH, Neufeld AH. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage. 2003 Nov; 20(3):1714-22. PMID: 14642481.
      View in: PubMed
    24. Ju W, Kim KY, Neufeld AH. Increased activity of cyclooxygenase-2 signals early neurodegenerative events in the rat retina following transient ischemia. Exp Eye Res. 2003 Aug; 77(2):137-45. PMID: 12873443.
      View in: PubMed
    25. Ju W, Neufeld AH. Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J Comp Neurol. 2002 Oct 28; 452(4):392-9. PMID: 12355421.
      View in: PubMed
    26. Ju W, Gwon JS, Park SJ, Kim KY, Moon JI, Lee MY, Oh SJ, Chun MH. Growth-associated protein 43 is up-regulated in the ganglion cells of the ischemic rat retina. Neuroreport. 2002 May 07; 13(6):861-5. PMID: 11997702.
      View in: PubMed
    Wonkyu's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (156) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (6) people
    _
    Related Authors
    People who share related concepts with this person.
    See all (60) people
    _
    ↑