Wonkyu Ju

Title(s)	Adjunct Professor, Ophthalmology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Mitochondrial Protection in Glaucomatous Optic Neuropathy
NIH/NEI R01 EY031697Sep 1, 2020 - Jun 30, 2024
Role: Principal Investigator

Neuroprotective Role of Sirt6 in Glaucoma
NIH/NEI R01 EY031054Jun 1, 2020 - May 31, 2025
Role: Consortium Principal Investigator

Mitochondrial Dysfunction in Glaucomatous Optic Neuropathy
NIH R01EY018658Dec 1, 2007 - Aug 31, 2019
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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cAMP/PKA pathway and mitochondrial protection in oxidative stress-induced optic nerve head astrocytes. Neural Regen Res. 2021 Jan; 16(1):108-109. Kim KY, Ju WK. PMID: 32788457; PMCID: PMC7818876.

View in: PubMed Mentions:
Effect of Ubiquinol on Glaucomatous Neurodegeneration and Oxidative Stress: Studies for Retinal Ganglion Cell Survival and/or Visual Function. Antioxidants (Basel). 2020 Oct 03; 9(10). Edwards G, Lee Y, Kim M, Bhanvadia S, Kim KY, Ju WK. PMID: 33023026; PMCID: PMC7599950.

View in: PubMed Mentions: 4
Corrigendum to "Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization". Oxid Med Cell Longev. 2020; 2020:9410289. Ju WK, Shim MS, Kim KY, Park TL, Ahn S, Edwards G, Weinreb RN. PMID: 33082914; PMCID: PMC7556093.

View in: PubMed Mentions: Fields:
Cel Cell Biology Met Metabolism
AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration. Redox Biol. 2020 10; 37:101703. Choi SH, Kim KY, Perkins GA, Phan S, Edwards G, Xia Y, Kim J, Skowronska-Krawczyk D, Weinreb RN, Ellisman MH, Miller YI, Ju WK. PMID: 32896719; PMCID: PMC7484594.

View in: PubMed Mentions: 5 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals Cells
Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. Cell Death Dis. 2020 04 20; 11(4):254. Edwards G, Perkins GA, Kim KY, Kong Y, Lee Y, Choi SH, Liu Y, Skowronska-Krawczyk D, Weinreb RN, Zangwill L, Strack S, Ju WK. PMID: 32312949; PMCID: PMC7170863.

View in: PubMed Mentions: 9 Fields:
Cel Cell Biology Int Internal Medicine
Translation:Animals Cells
Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization. Oxid Med Cell Longev. 2019; 2019:8060962. Ju WK, Shim MS, Kim KY, Park TL, Ahn S, Edwards G, Weinreb RN. PMID: 31781352; PMCID: PMC6875302.

View in: PubMed Mentions: 7 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals Cells
Ubiquinol promotes retinal ganglion cell survival and blocks the apoptotic pathway in ischemic retinal degeneration. Biochem Biophys Res Commun. 2018 09 18; 503(4):2639-2645. Ju WK, Shim MS, Kim KY, Bu JH, Park TL, Ahn S, Weinreb RN. PMID: 30107910; PMCID: PMC6133725.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals Cells
Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line. Biochem Biophys Res Commun. 2018 09 18; 503(4):2690-2697. Shim MS, Kim KY, Noh M, Ko JY, Ahn S, An MA, Iwata T, Perkins GA, Weinreb RN, Ju WK. PMID: 30100066; PMCID: PMC6133749.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals Cells
Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. Cell Death Dis. 2018 02 19; 9(3):285. Shim MS, Kim KY, Bu JH, Nam HS, Jeong SW, Park TL, Ellisman MH, Weinreb RN, Ju WK. PMID: 29459737; PMCID: PMC5833440.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology Int Internal Medicine
Translation:Humans Animals Cells
Role of cyclic AMP in the eye with glaucoma. BMB Rep. 2017 Feb; 50(2):60-70. Shim MS, Kim KY, Ju WK. PMID: 27916026; PMCID: PMC5342868.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Humans Animals Cells
Corrigendum: Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2017 01 19; 7:40460. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK. PMID: 28102236; PMCID: PMC5244623.

View in: PubMed Mentions: 1 Fields:
Sci Science
Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2016 Sep 22; 6:33830. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK. PMID: 27654856; PMCID: PMC5031982.

View in: PubMed Mentions: 32 Fields:
Sci Science
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia. 2015 May; 63(5):736-53. Ju WK, Kim KY, Noh YH, Hoshijima M, Lukas TJ, Ellisman MH, Weinreb RN, Perkins GA. PMID: 25557093; PMCID: PMC4373968.

View in: PubMed Mentions: 23 Fields:
Neu Neurology
Translation:Humans Animals Cells
Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury. Apoptosis. 2014 Apr; 19(4):603-14. Lee D, Kim KY, Shim MS, Kim SY, Ellisman MH, Weinreb RN, Ju WK. PMID: 24337820; PMCID: PMC3938850.

View in: PubMed Mentions: 34 Fields:
Cel Cell Biology
Translation:Animals Cells
Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2014 Feb 18; 55(2):993-1005. Lee D, Shim MS, Kim KY, Noh YH, Kim H, Kim SY, Weinreb RN, Ju WK. PMID: 24458150; PMCID: PMC3929080.

View in: PubMed Mentions: 63 Fields:
Oph Ophthalmology
Translation:Animals Cells
Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury. PLoS One. 2012; 7(10):e47098. Lee D, Kim KY, Noh YH, Chai S, Lindsey JD, Ellisman MH, Weinreb RN, Ju WK. PMID: 23056591; PMCID: PMC3467218.

View in: PubMed Mentions: 38 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2837-43. Park SW, Kim KY, Lindsey JD, Dai Y, Heo H, Nguyen DH, Ellisman MH, Weinreb RN, Ju WK. PMID: 21372007; PMCID: PMC3088566.

View in: PubMed Mentions: 64 Fields:
Oph Ophthalmology
Translation:Animals Cells
Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. Invest Ophthalmol Vis Sci. 2011 Apr 16; 52(5):2468-76. Dai Y, Weinreb RN, Kim KY, Nguyen D, Park S, Sun X, Lindsey JD, Ellisman MH, Ju WK. PMID: 21220562; PMCID: PMC3088543.

View in: PubMed Mentions: 17 Fields:
Oph Ophthalmology
Translation:Animals Cells
Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay. Methods Mol Biol. 2011; 740:149-56. Ju WK, Kim KY. PMID: 21468976; PMCID: PMC4104946.

View in: PubMed Mentions: 9 Fields:
Mol Molecular Biology
Translation:Animals
Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma. Mol Vis. 2010 Jul 15; 16:1331-42. Ju WK, Kim KY, Duong-Polk KX, Lindsey JD, Ellisman MH, Weinreb RN. PMID: 20664796; PMCID: PMC2905637.

View in: PubMed Mentions: 34 Fields:
Mol Molecular Biology Oph Ophthalmology
Translation:Animals Cells
Recharacterization of the RGC-5 retinal ganglion cell line. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4267-72. Van Bergen NJ, Wood JP, Chidlow G, Trounce IA, Casson RJ, Ju WK, Weinreb RN, Crowston JG. PMID: 19443730.

View in: PubMed Mentions: 94 Fields:
Oph Ophthalmology
Translation:Animals Cells
Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis. 2009; 15:120-34. Ju WK, Kim KY, Lindsey JD, Angert M, Patel A, Scott RT, Liu Q, Crowston JG, Ellisman MH, Perkins GA, Weinreb RN. PMID: 19169378; PMCID: PMC2629709.

View in: PubMed Mentions: 39 Fields:
Mol Molecular Biology Oph Ophthalmology
Translation:Animals Cells
Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina. Mol Vis. 2008; 14:2629-38. Ju WK, Lindsey JD, Angert M, Patel A, Weinreb RN. PMID: 19122832; PMCID: PMC2613079.

View in: PubMed Mentions: 22 Fields:
Mol Molecular Biology Oph Ophthalmology
Translation:Animals Cells
Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):707-16. Ju WK, Kim KY, Angert M, Duong-Polk KX, Lindsey JD, Ellisman MH, Weinreb RN. PMID: 18936150; PMCID: PMC2678967.

View in: PubMed Mentions: 42 Fields:
Oph Ophthalmology
Translation:Animals Cells
Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4903-11. Ju WK, Kim KY, Lindsey JD, Angert M, Duong-Polk KX, Scott RT, Kim JJ, Kukhmazov I, Ellisman MH, Perkins GA, Weinreb RN. PMID: 18469184; PMCID: PMC2688012.

View in: PubMed Mentions: 65 Fields:
Oph Ophthalmology
Translation:Animals Cells
In vivo imaging of murine retinal ganglion cells. J Neurosci Methods. 2008 Mar 15; 168(2):475-8. Leung CK, Lindsey JD, Crowston JG, Ju WK, Liu Q, Bartsch DU, Weinreb RN. PMID: 18079000.

View in: PubMed Mentions: 30 Fields:
Neu Neurology
Translation:Animals Cells
Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4580-9. Liu Q, Ju WK, Crowston JG, Xie F, Perry G, Smith MA, Lindsey JD, Weinreb RN. PMID: 17898281.

View in: PubMed Mentions: 58 Fields:
Oph Ophthalmology
Translation:Animals Cells
Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2145-51. Ju WK, Liu Q, Kim KY, Crowston JG, Lindsey JD, Agarwal N, Ellisman MH, Perkins GA, Weinreb RN. PMID: 17460273.

View in: PubMed Mentions: 54 Fields:
Oph Ophthalmology
Translation:Animals Cells
OPA1 expression in the normal rat retina and optic nerve. J Comp Neurol. 2005 Jul 18; 488(1):1-10. Ju WK, Misaka T, Kushnareva Y, Nakagomi S, Agarwal N, Kubo Y, Lipton SA, Bossy-Wetzel E. PMID: 15912498; PMCID: PMC1350956.

View in: PubMed Mentions: 23 Fields:
Neu Neurology
Translation:Animals Cells
Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia. Neurobiol Aging. 2004 Apr; 25(4):491-500. Kim KY, Ju WK, Neufeld AH. PMID: 15013570.

View in: PubMed Mentions: 19 Fields:
Ger Geriatrics Neu Neurology Phy Physiology
Translation:Animals Cells
Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage. 2003 Nov; 20(3):1714-22. Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. PMID: 14642481.

View in: PubMed Mentions: 795 Fields:
Dia Diagnostic Imaging
Translation:Animals Cells
Increased activity of cyclooxygenase-2 signals early neurodegenerative events in the rat retina following transient ischemia. Exp Eye Res. 2003 Aug; 77(2):137-45. Ju WK, Kim KY, Neufeld AH. PMID: 12873443.

View in: PubMed Mentions: 12 Fields:
Oph Ophthalmology
Translation:Animals Cells
Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro. J Ocul Pharmacol Ther. 2003 Feb; 19(1):45-54. Davies SS, Ju WK, Neufeld AH, Abran D, Chemtob S, Roberts LJ. PMID: 12648303.

View in: PubMed Mentions: 16 Fields:
Dru Drug Therapy Oph Ophthalmology Pha Pharmacology
Translation:Humans Animals Cells
Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J Comp Neurol. 2002 Oct 28; 452(4):392-9. Ju WK, Neufeld AH. PMID: 12355421.

View in: PubMed Mentions: 13 Fields:
Neu Neurology
Translation:Humans Animals Cells
Growth-associated protein 43 is up-regulated in the ganglion cells of the ischemic rat retina. Neuroreport. 2002 May 07; 13(6):861-5. Ju WK, Gwon JS, Park SJ, Kim KY, Moon JI, Lee MY, Oh SJ, Chun MH. PMID: 11997702.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Translation:Animals Cells