Wonkyu Ju

Title(s)	Adjunct Professor, Ophthalmology
School	Vc-health Sciences-schools
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Research

research activities and funding

Macrophage Inflammarafts and Mitochondrial Dysfunction in Atherosclerosis
NIH/NHLBI R01HL171505Feb 1, 2024 - Jan 21, 2028
Role: Co-Investigator

AIBP-mediated neuroprotection in glaucomatous optic neuropathy
NIH/NEI R01EY034116Sep 30, 2023 - May 31, 2027
Role: Principle Investigator

Development of AAV-AIBP for neuroprotection in glaucoma
NIH/NINDS UG3NS129684Aug 15, 2023 - Jul 31, 2025
Role: Principal Investigator

Reversing Microglial Inflammarafts and Mitochondrial Dysfunction in Alzheimer's Disease
NIH/NIA R01AG081037Dec 1, 2022 - Nov 30, 2027
Role: Co-Principal Investigator

AAV-AIBP Therapy for Alzheimer's Disease
NIH/NIA R41AG081004Sep 30, 2022 - May 31, 2025
Role: Principal Investigator

CXCR3-Mediated Cell-Cell Communication in Glaucoma
NIH/NEI R01EY034376Sep 1, 2022 - Jul 31, 2027
Role: Consortium Principal Investigator

Mitochondrial Protection in Glaucomatous Optic Neuropathy
NIH/NEI R01EY031697Sep 1, 2020 - Jun 30, 2025
Role: Principal Investigator

Neuroprotective Role of Sirt6 in Glaucoma
NIH/NEI R01EY031054Jun 1, 2020 - May 31, 2025
Role: Consortium Principal Investigator

Mitochondrial Dysfunction in Glaucomatous Optic Neuropathy
NIH R01EY018658Dec 1, 2007 - Aug 31, 2019
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Stress induced aging in mouse eye. Aging Cell. 2022 Dec; 21(12):e13737. Xu Q, Rydz C, Nguyen Huu VA, Rocha L, Palomino La Torre C, Lee I, Cho W, Jabari M, Donello J, Lyon DC, Brooke RT, Horvath S, Weinreb RN, Ju WK, Foik A, Skowronska-Krawczyk D. PMID: 36397653; PMCID: PMC9741506.

View in: PubMed Mentions: 17 Fields:
Cel Cell Biology
Translation:Animals Cells
Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells. Prog Retin Eye Res. 2023 Jul; 95:101136. Ju WK, Perkins GA, Kim KY, Bastola T, Choi WY, Choi SH. PMID: 36400670.

View in: PubMed Mentions: 42 Fields:
Oph Ophthalmology
Translation:Humans Cells
cAMP/PKA pathway and mitochondrial protection in oxidative stress-induced optic nerve head astrocytes. Neural Regen Res. 2021 Jan; 16(1):108-109. Kim KY, Ju WK. PMID: 32788457; PMCID: PMC7818876.

View in: PubMed Mentions: 1
Effect of Ubiquinol on Glaucomatous Neurodegeneration and Oxidative Stress: Studies for Retinal Ganglion Cell Survival and/or Visual Function. Antioxidants (Basel). 2020 Oct 03; 9(10). Edwards G, Lee Y, Kim M, Bhanvadia S, Kim KY, Ju WK. PMID: 33023026; PMCID: PMC7599950.

View in: PubMed Mentions: 11
Corrigendum to "Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization". Oxid Med Cell Longev. 2020; 2020:9410289. Ju WK, Shim MS, Kim KY, Park TL, Ahn S, Edwards G, Weinreb RN. PMID: 33082914; PMCID: PMC7556093.

View in: PubMed Mentions: Fields:
Cel Cell Biology Met Metabolism
AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration. Redox Biol. 2020 10; 37:101703. Choi SH, Kim KY, Perkins GA, Phan S, Edwards G, Xia Y, Kim J, Skowronska-Krawczyk D, Weinreb RN, Ellisman MH, Miller YI, Ju WK. PMID: 32896719; PMCID: PMC7484594.

View in: PubMed Mentions: 23 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals Cells
Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. Cell Death Dis. 2020 04 20; 11(4):254. Edwards G, Perkins GA, Kim KY, Kong Y, Lee Y, Choi SH, Liu Y, Skowronska-Krawczyk D, Weinreb RN, Zangwill L, Strack S, Ju WK. PMID: 32312949; PMCID: PMC7170863.

View in: PubMed Mentions: 27 Fields:
Cel Cell Biology Int Internal Medicine
Translation:Animals Cells
Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization. Oxid Med Cell Longev. 2019; 2019:8060962. Ju WK, Shim MS, Kim KY, Park TL, Ahn S, Edwards G, Weinreb RN. PMID: 31781352; PMCID: PMC6875302.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals Cells
Ubiquinol promotes retinal ganglion cell survival and blocks the apoptotic pathway in ischemic retinal degeneration. Biochem Biophys Res Commun. 2018 09 18; 503(4):2639-2645. Ju WK, Shim MS, Kim KY, Bu JH, Park TL, Ahn S, Weinreb RN. PMID: 30107910; PMCID: PMC6133725.

View in: PubMed Mentions: 15 Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals Cells
Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line. Biochem Biophys Res Commun. 2018 09 18; 503(4):2690-2697. Shim MS, Kim KY, Noh M, Ko JY, Ahn S, An MA, Iwata T, Perkins GA, Weinreb RN, Ju WK. PMID: 30100066; PMCID: PMC6133749.

View in: PubMed Mentions: 9 Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals Cells
Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. Cell Death Dis. 2018 02 19; 9(3):285. Shim MS, Kim KY, Bu JH, Nam HS, Jeong SW, Park TL, Ellisman MH, Weinreb RN, Ju WK. PMID: 29459737; PMCID: PMC5833440.

View in: PubMed Mentions: 15 Fields:
Cel Cell Biology Int Internal Medicine
Translation:Humans Animals Cells
Role of cyclic AMP in the eye with glaucoma. BMB Rep. 2017 Feb; 50(2):60-70. Shim MS, Kim KY, Ju WK. PMID: 27916026; PMCID: PMC5342868.

View in: PubMed Mentions: 19 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Humans Animals Cells
Corrigendum: Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2017 01 19; 7:40460. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK. PMID: 28102236; PMCID: PMC5244623.

View in: PubMed Mentions: Fields:
Sci Science
Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2016 Sep 22; 6:33830. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK. PMID: 27654856; PMCID: PMC5031982.

View in: PubMed Mentions: 43 Fields:
Sci Science
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia. 2015 May; 63(5):736-53. Ju WK, Kim KY, Noh YH, Hoshijima M, Lukas TJ, Ellisman MH, Weinreb RN, Perkins GA. PMID: 25557093; PMCID: PMC4373968.

View in: PubMed Mentions: 32 Fields:
Neu Neurology
Translation:Humans Animals Cells
Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury. Apoptosis. 2014 Apr; 19(4):603-14. Lee D, Kim KY, Shim MS, Kim SY, Ellisman MH, Weinreb RN, Ju WK. PMID: 24337820; PMCID: PMC3938850.

View in: PubMed Mentions: 46 Fields:
Cel Cell Biology
Translation:Animals Cells
Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury. Cell Death Dis. 2014 Mar 06; 5:e1105. Kim SY, Shim MS, Kim KY, Weinreb RN, Wheeler LA, Ju WK. PMID: 24603333; PMCID: PMC3973219.

View in: PubMed Mentions: 36 Fields:
Cel Cell Biology Int Internal Medicine
Translation:Animals Cells
Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2014 Feb 18; 55(2):993-1005. Lee D, Shim MS, Kim KY, Noh YH, Kim H, Kim SY, Weinreb RN, Ju WK. PMID: 24458150; PMCID: PMC3929080.

View in: PubMed Mentions: 86 Fields:
Oph Ophthalmology
Translation:Animals Cells
Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury. PLoS One. 2012; 7(10):e47098. Lee D, Kim KY, Noh YH, Chai S, Lindsey JD, Ellisman MH, Weinreb RN, Ju WK. PMID: 23056591; PMCID: PMC3467218.

View in: PubMed Mentions: 44 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics. Cell Death Dis. 2011 Dec 08; 2:e240. Nguyen D, Alavi MV, Kim KY, Kang T, Scott RT, Noh YH, Lindsey JD, Wissinger B, Ellisman MH, Weinreb RN, Perkins GA, Ju WK. PMID: 22158479; PMCID: PMC3252734.

View in: PubMed Mentions: 116 Fields:
Cel Cell Biology Int Internal Medicine
Translation:Animals Cells
A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2837-43. Park SW, Kim KY, Lindsey JD, Dai Y, Heo H, Nguyen DH, Ellisman MH, Weinreb RN, Ju WK. PMID: 21372007; PMCID: PMC3088566.

View in: PubMed Mentions: 68 Fields:
Oph Ophthalmology
Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. Invest Ophthalmol Vis Sci. 2011 Apr 16; 52(5):2468-76. Dai Y, Weinreb RN, Kim KY, Nguyen D, Park S, Sun X, Lindsey JD, Ellisman MH, Ju WK. PMID: 21220562; PMCID: PMC3088543.

View in: PubMed Mentions: 17 Fields:
Oph Ophthalmology
Translation:Animals Cells
Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay. Methods Mol Biol. 2011; 740:149-56. Ju WK, Kim KY. PMID: 21468976; PMCID: PMC4104946.

View in: PubMed Mentions: 11 Fields:
Mol Molecular Biology
Translation:Animals
Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma. Mol Vis. 2010 Jul 15; 16:1331-42. Ju WK, Kim KY, Duong-Polk KX, Lindsey JD, Ellisman MH, Weinreb RN. PMID: 20664796; PMCID: PMC2905637.

View in: PubMed Mentions: 37 Fields:
Mol Molecular Biology Oph Ophthalmology
Translation:Animals Cells
Ultrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic glioma. Neuroscience. 2010 Sep 29; 170(1):178-88. Kim KY, Ju WK, Hegedus B, Gutmann DH, Ellisman MH. PMID: 20600672; PMCID: PMC2926211.

View in: PubMed Mentions: 19 Fields:
Neu Neurology
Translation:Animals Cells
Recharacterization of the RGC-5 retinal ganglion cell line. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4267-72. Van Bergen NJ, Wood JP, Chidlow G, Trounce IA, Casson RJ, Ju WK, Weinreb RN, Crowston JG. PMID: 19443730.

View in: PubMed Mentions: 96 Fields:
Oph Ophthalmology
Translation:Animals Cells
Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis. 2009; 15:120-34. Ju WK, Kim KY, Lindsey JD, Angert M, Patel A, Scott RT, Liu Q, Crowston JG, Ellisman MH, Perkins GA, Weinreb RN. PMID: 19169378; PMCID: PMC2629709.

View in: PubMed Mentions: 36 Fields:
Mol Molecular Biology Oph Ophthalmology
Translation:Animals Cells
Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina. Mol Vis. 2008; 14:2629-38. Ju WK, Lindsey JD, Angert M, Patel A, Weinreb RN. PMID: 19122832; PMCID: PMC2613079.

View in: PubMed Mentions: 22 Fields:
Mol Molecular Biology Oph Ophthalmology
Translation:Animals Cells
Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):707-16. Ju WK, Kim KY, Angert M, Duong-Polk KX, Lindsey JD, Ellisman MH, Weinreb RN. PMID: 18936150; PMCID: PMC2678967.

View in: PubMed Mentions: 45 Fields:
Oph Ophthalmology
Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4903-11. Ju WK, Kim KY, Lindsey JD, Angert M, Duong-Polk KX, Scott RT, Kim JJ, Kukhmazov I, Ellisman MH, Perkins GA, Weinreb RN. PMID: 18469184; PMCID: PMC2688012.

View in: PubMed Mentions: 75 Fields:
Oph Ophthalmology
In vivo imaging of murine retinal ganglion cells. J Neurosci Methods. 2008 Mar 15; 168(2):475-8. Leung CK, Lindsey JD, Crowston JG, Ju WK, Liu Q, Bartsch DU, Weinreb RN. PMID: 18079000.

View in: PubMed Mentions: 27 Fields:
Neu Neurology
Translation:Animals Cells
Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4580-9. Liu Q, Ju WK, Crowston JG, Xie F, Perry G, Smith MA, Lindsey JD, Weinreb RN. PMID: 17898281.

View in: PubMed Mentions: 58 Fields:
Oph Ophthalmology
Translation:Animals Cells
Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2145-51. Ju WK, Liu Q, Kim KY, Crowston JG, Lindsey JD, Agarwal N, Ellisman MH, Perkins GA, Weinreb RN. PMID: 17460273.

View in: PubMed Mentions: 53 Fields:
Oph Ophthalmology
Translation:Animals Cells
OPA1 expression in the normal rat retina and optic nerve. J Comp Neurol. 2005 Jul 18; 488(1):1-10. Ju WK, Misaka T, Kushnareva Y, Nakagomi S, Agarwal N, Kubo Y, Lipton SA, Bossy-Wetzel E. PMID: 15912498; PMCID: PMC1350956.

View in: PubMed Mentions: 19 Fields:
Neu Neurology
Translation:Animals Cells
Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia. Neurobiol Aging. 2004 Apr; 25(4):491-500. Kim KY, Ju WK, Neufeld AH. PMID: 15013570.

View in: PubMed Mentions: 12 Fields:
Ger Geriatrics Neu Neurology Phy Physiology
Translation:Animals Cells
Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage. 2003 Nov; 20(3):1714-22. Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. PMID: 14642481.

View in: PubMed Mentions: 738 Fields:
Dia Diagnostic Imaging
Translation:Animals Cells
Increased activity of cyclooxygenase-2 signals early neurodegenerative events in the rat retina following transient ischemia. Exp Eye Res. 2003 Aug; 77(2):137-45. Ju WK, Kim KY, Neufeld AH. PMID: 12873443.

View in: PubMed Mentions: 10 Fields:
Oph Ophthalmology
Translation:Animals Cells
Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro. J Ocul Pharmacol Ther. 2003 Feb; 19(1):45-54. Davies SS, Ju WK, Neufeld AH, Abran D, Chemtob S, Roberts LJ. PMID: 12648303.

View in: PubMed Mentions: 15 Fields:
Dru Drug Therapy Oph Ophthalmology Pha Pharmacology
Translation:Humans Animals Cells
Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J Comp Neurol. 2002 Oct 28; 452(4):392-9. Ju WK, Neufeld AH. PMID: 12355421.

View in: PubMed Mentions: 12 Fields:
Neu Neurology
Translation:Humans Animals Cells
Growth-associated protein 43 is up-regulated in the ganglion cells of the ischemic rat retina. Neuroreport. 2002 May 07; 13(6):861-5. Ju WK, Gwon JS, Park SJ, Kim KY, Moon JI, Lee MY, Oh SJ, Chun MH. PMID: 11997702.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Translation:Animals Cells