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Hemal Patel

TitleTeacher
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #9125
La Jolla CA 92093
Phone858-642-3052
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    Collapse Research 
    Collapse Research Activities and Funding
    Caveolae as capacitors for oxygen
    NIH/NIA R21AG052722Aug 15, 2017 - Apr 30, 2019
    Role: Principal Investigator
    Interdisciplinary Anesthesiology Research Training Program
    NIH/NIGMS T32GM121318Jul 1, 2017 - Jun 30, 2022
    Role: Principal Investigator
    AKIP1 regulation of PKA and NF-KB in the heart
    VA I01BX001963Apr 1, 2013 - Mar 31, 2021
    Role: Principal Investigator
    Protection of the Aged Myocardium
    NIH/NHLBI R01HL107200Jun 15, 2011 - Apr 30, 2015
    Role: Principal Investigator
    Caveolae and the Aged Myocardium
    VA I01BX000637Apr 1, 2011 - Mar 31, 2015
    Role: Principal Investigator
    Caveolae, mitochondria, and cardiac protection
    NIH/NHLBI R01HL091071Dec 1, 2007 - Mar 31, 2020
    Role: Principal Investigator
    AC6 as therapy for primary pulmonary hypertension
    NIH/NHLBI F32HL074625Sep 1, 2003 - Aug 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Godoy JC, Niesman IR, Busija AR, Kassan A, Schilling JM, Schwarz A, Alvarez EA, Dalton ND, Drummond JC, Roth DM, Kararigas G, Patel HH, Zemljic-Harpf AE. Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes. FASEB J. 2018 Aug 31; fj201800876R. PMID: 30169110.
      View in: PubMed
    2. Bryant SM, Kong CHT, Watson JJ, Gadeberg HC, Roth DM, Patel HH, Cannell MB, James AF, Orchard CH. CAVEOLIN-3 KO DISRUPTS T-TUBULE STRUCTURE AND DECREASES T-TUBULAR ICa DENSITY IN MOUSE VENTRICULAR MYOCYTES. Am J Physiol Heart Circ Physiol. 2018 Jul 20. PMID: 30028203.
      View in: PubMed
    3. Haushalter KJ, Patel HH. Not all fiber is good for you: Targeting fibroblast activation to improve cardiac function in heart failure. Am J Physiol Heart Circ Physiol. 2018 Jul 13. PMID: 30004238.
      View in: PubMed
    4. Kong CHT, Bryant SM, Watson JJ, Gadeberg HC, Roth DM, Patel HH, Cannell MB, Orchard CH, James AF. The Effects of Aging on the Regulation of T-Tubular ICa by Caveolin in Mouse Ventricular Myocytes. J Gerontol A Biol Sci Med Sci. 2018 May 09; 73(6):711-719. PMID: 29236992.
      View in: PubMed
    5. Meier A, Gross ETE, Schilling JM, Seelige R, Jung Y, Santosa E, Searles S, Lin T, Tu XM, Patel HH, Bui JD. Isoflurane Impacts Murine Melanoma Growth in a Sex-Specific, Immune-Dependent Manner: A Brief Report. Anesth Analg. 2018 Mar 21. PMID: 29570154.
      View in: PubMed
    6. Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS. Phosphorylation of protein kinase A (PKA) regulatory subunit RIa by protein kinase G (PKG) primes PKA for catalytic activity in cells. J Biol Chem. 2018 Mar 23; 293(12):4411-4421. PMID: 29378851.
      View in: PubMed
    7. Schilling JM, Head BP, Patel HH. Caveolins as Regulators of Stress Adaptation. Mol Pharmacol. 2018 Apr; 93(4):277-285. PMID: 29358220.
      View in: PubMed
    8. Patel HH, Roth DM. No pain, no gain: balancing central versus peripheral benefits of analgesics in the age of the opioid crisis. Br J Pharmacol. 2018 Mar; 175(5):855-856. PMID: 29243218.
      View in: PubMed
    9. Russell J, Du Toit EF, Peart JN, Patel HH, Headrick JP. Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection. Cardiovasc Diabetol. 2017 Dec 04; 16(1):155. PMID: 29202762.
      View in: PubMed
    10. Parikh J, Zemljic-Harpf A, Fu J, Giamouridis D, Hsieh TC, Kassan A, Murthy KS, Bhargava V, Patel HH, Rajasekaran MR. Altered Penile Caveolin Expression in Diabetes: Potential Role in Erectile Dysfunction. J Sex Med. 2017 Oct; 14(10):1177-1186. PMID: 28923309.
      View in: PubMed
    11. Egawa J, Zemljic-Harpf A, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2017 Jul 31; 1-12. PMID: 28981594.
      View in: PubMed
    12. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth DM. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. PMID: 28498861.
      View in: PubMed
    13. Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam CD, Roth DM, Patel HH, Patel PM, Head BP. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J. 2017 08; 31(8):3403-3411. PMID: 28450301.
      View in: PubMed
    14. Kassan M, Vikram A, Kim YR, Li Q, Kassan A, Patel HH, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K. Corrigendum: Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress. Sci Rep. 2017 Apr 10; 7:46123. PMID: 28394317.
      View in: PubMed
    15. Thomas JL, Pham H, Li Y, Hall E, Perkins GA, Ali SS, Patel HH, Singh P. Hypoxia-inducible factor-1a activation improves renal oxygenation and mitochondrial function in early chronic kidney disease. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F282-F290. PMID: 28331062.
      View in: PubMed
    16. See Hoe L, Patel HH, Peart JN. Delta Opioid Receptors and Cardioprotection. Handb Exp Pharmacol. 2017 Feb 26. PMID: 28238076.
      View in: PubMed
    17. Liu X, Wong SS, Taype CA, Kim J, Shentu TP, Espinoza CR, Finley JC, Bradley JE, Head BP, Patel HH, Mah EJ, Hagood JS. Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution. Lab Invest. 2017 03; 97(3):256-267. PMID: 28165468.
      View in: PubMed
    18. Busija AR, Patel HH, Insel PA. Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C459-C477. PMID: 28122734.
      View in: PubMed
    19. Kassan A, Egawa J, Zhang Z, Almenar-Queralt A, Nguyen QM, Lajevardi Y, Kim K, Posadas E, Jeste DV, Roth DM, Patel PM, Patel HH, Head BP. Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia. J Neurophysiol. 2017 Jan 01; 117(1):436-444. PMID: 27832597.
      View in: PubMed
    20. Flick M, Albrecht M, Oei GTML, Steenstra R, Kerindongo RP, Zuurbier CJ, Patel HH, Hollmann MW, Preckel B, Weber NC. Helium postconditioning regulates expression of caveolin-1 and -3 and induces RISK pathway activation after ischaemia/reperfusion in cardiac tissue of rats. Eur J Pharmacol. 2016 Nov 15; 791:718-725. PMID: 27742593.
      View in: PubMed
    21. Kassan A, Pham U, Nguyen Q, Reichelt ME, Cho E, Patel PM, Roth DM, Head BP, Patel HH. Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion. Am J Physiol Cell Physiol. 2016 Dec 01; 311(6):C854-C865. PMID: 27707689.
      View in: PubMed
    22. Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30; 119(8):931-43. PMID: 27576469.
      View in: PubMed
    23. See Hoe LE, Schilling JM, Busija AR, Haushalter KJ, Ozberk V, Keshwani MM, Roth DM, Toit ED, Headrick JP, Patel HH, Peart JN. Chronic ß1-adrenoceptor blockade impairs ischaemic tolerance and preconditioning in murine myocardium. Eur J Pharmacol. 2016 Oct 15; 789:1-7. PMID: 27373851; PMCID: PMC5037019 [Available on 10/15/17].
    24. Wagner NM, Gross ER, Patel HH. A Slick Way Volatile Anesthetics Reduce Myocardial Injury. Anesthesiology. 2016 May; 124(5):986-8. PMID: 26845142.
      View in: PubMed
    25. Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 2016 May; 111(3):28. PMID: 27023865.
      View in: PubMed
    26. Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016 Feb 15; 6:20831. PMID: 26877209; PMCID: PMC4753484.
    27. Ray S, Kassan A, Busija AR, Rangamani P, Patel HH. The plasma membrane as a capacitor for energy and metabolism. Am J Physiol Cell Physiol. 2016 Feb 01; 310(3):C181-92. PMID: 26771520; PMCID: PMC4888523 [Available on 02/01/17].
    28. Schilling JM, Patel HH. Non-canonical roles for caveolin in regulation of membrane repair and mitochondria: implications for stress adaptation with age. J Physiol. 2016 08 15; 594(16):4581-9. PMID: 26333003; PMCID: PMC4983620 [Available on 08/15/17].
    29. Mandyam CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP. Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice. Biol Psychiatry. 2017 01 15; 81(2):101-110. PMID: 26592463.
      View in: PubMed
    30. Stary CM, Patel HH, Roth DM. Epigenetics: The Epicenter for Future Anesthesia Research? Anesthesiology. 2015 Oct; 123(4):743-4. PMID: 26259141.
      View in: PubMed
    31. Markandeya YS, Phelan LJ, Woon MT, Keefe AM, Reynolds CR, August BK, Hacker TA, Roth DM, Patel HH, Balijepalli RC. Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase Ca in Cardiomyocytes. J Biol Chem. 2015 Sep 04; 290(36):22085-100. PMID: 26170457; PMCID: PMC4571960.
    32. Sun J, Nguyen T, Aponte AM, Menazza S, Kohr MJ, Roth DM, Patel HH, Murphy E, Steenbergen C. Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. Cardiovasc Res. 2015 May 01; 106(2):227-36. PMID: 25694588; PMCID: PMC4416121.
    33. Chan A, Jiang J, Fridman A, Guo LT, Shelton GD, Liu MT, Green C, Haushalter KJ, Patel HH, Lee J, Yoon D, Burney T, Mukai D, Mahon SB, Brenner M, Pilz RB, Boss GR. Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection. J Med Chem. 2015 Feb 26; 58(4):1750-9. PMID: 25650735; PMCID: PMC4494098.
    34. Schilling JM, Roth DM, Patel HH. Caveolins in cardioprotection - translatability and mechanisms. Br J Pharmacol. 2015 Apr; 172(8):2114-25. PMID: 25377989; PMCID: PMC4386985.
    35. Zúñiga-Hertz JP, Rebelato E, Kassan A, Khalifa AM, Ali SS, Patel HH, Abdulkader F. Distinct pathways of cholesterol biosynthesis impact on insulin secretion. J Endocrinol. 2015 Jan; 224(1):75-84. PMID: 25453115.
      View in: PubMed
    36. Tran C, Stary CM, Schilling JM, Bentley B, Patel HH, Roth DM. Role of caveolin-3 in lymphocyte activation. Life Sci. 2015 Jan 15; 121:35-9. PMID: 25476831; PMCID: PMC4410709.
    37. Israeli-Rosenberg S, Chen C, Li R, Deussen DN, Niesman IR, Okada H, Patel HH, Roth DM, Ross RS. Caveolin modulates integrin function and mechanical activation in the cardiomyocyte. FASEB J. 2015 Feb; 29(2):374-84. PMID: 25366344; PMCID: PMC4314226.
    38. Wang J, Schilling JM, Niesman IR, Headrick JP, Finley JC, Kwan E, Patel PM, Head BP, Roth DM, Yue Y, Patel HH. Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent. Anesthesiology. 2014 Sep; 121(3):538-48. PMID: 24821070; PMCID: PMC4219636.
    39. White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab. 2014 Nov 01; 307(9):E764-72. PMID: 25159328; PMCID: PMC4216952.
    40. See Hoe LE, Schilling JM, Tarbit E, Kiessling CJ, Busija AR, Niesman IR, Du Toit E, Ashton KJ, Roth DM, Headrick JP, Patel HH, Peart JN. Sarcolemmal cholesterol and caveolin-3 dependence of cardiac function, ischemic tolerance, and opioidergic cardioprotection. Am J Physiol Heart Circ Physiol. 2014 Sep 15; 307(6):H895-903. PMID: 25063791; PMCID: PMC4166742.
    41. Patel HH, McDonough AA. Of mice and men: modeling cardiovascular complexity in diabetes. Focus on "Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart". Am J Physiol Cell Physiol. 2014 Sep 15; 307(6):C497-8. PMID: 25031018; PMCID: PMC4166741.
    42. Yang KC, Rutledge CA, Mao M, Bakhshi FR, Xie A, Liu H, Bonini MG, Patel HH, Minshall RD, Dudley SC. Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase. Circ Arrhythm Electrophysiol. 2014 Aug; 7(4):701-10. PMID: 25017399.
      View in: PubMed
    43. Fridolfsson HN, Roth DM, Insel PA, Patel HH. Regulation of intracellular signaling and function by caveolin. FASEB J. 2014 Sep; 28(9):3823-31. PMID: 24858278; PMCID: PMC4139902.
    44. Nguyen L, Banks D, Manecke G, Shurter J, Schilling JM, Patel HH, Madani MM, Roth DM. Plasma vasopressin levels in patients with right-sided heart dysfunction and chronic thromboembolic pulmonary hypertension (CTEPH). J Cardiothorac Vasc Anesth. 2014 Jun; 28(3):601-7. PMID: 24746335.
      View in: PubMed
    45. Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth DM, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry. Behav Brain Res. 2014 Jul 01; 267:6-11. PMID: 24657594; PMCID: PMC4059187.
    46. Niesman IR, Schilling JM, Shapiro LA, Kellerhals SE, Bonds JA, Kleschevnikov AM, Cui W, Voong A, Krajewski S, Ali SS, Roth DM, Patel HH, Patel PM, Head BP. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation. 2014 Mar 03; 11:39. PMID: 24593993; PMCID: PMC3975903.
    47. Horikawa YT, Tsutsumi YM, Patel HH, Roth DM. Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection. Curr Pharm Des. 2014; 20(36):5681-9. PMID: 24502576; PMCID: PMC4119864.
    48. Peart JN, Pepe S, Reichelt ME, Beckett N, See Hoe L, Ozberk V, Niesman IR, Patel HH, Headrick JP. Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium. Exp Gerontol. 2014 Feb; 50:72-81. PMID: 24316036; PMCID: PMC4096533.
    49. Yu H, Tigchelaar W, Koonen DP, Patel HH, de Boer RA, van Gilst WH, Westenbrink BD, Silljé HH. AKIP1 expression modulates mitochondrial function in rat neonatal cardiomyocytes. PLoS One. 2013; 8(11):e80815. PMID: 24236204; PMCID: PMC3827472.
    50. Povero D, Eguchi A, Niesman IR, Andronikou N, de Mollerat du Jeu X, Mulya A, Berk M, Lazic M, Thapaliya S, Parola M, Patel HH, Feldstein AE. Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells. Sci Signal. 2013 Oct 08; 6(296):ra88. PMID: 24106341; PMCID: PMC4016801.
    51. Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA. Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Mol Pharmacol. 2013 Dec; 84(6):787-93. PMID: 24085841; PMCID: PMC3834140.
    52. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. PMID: 24091324; PMCID: PMC3784521.
    53. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. PMID: 24030101; PMCID: PMC3861721.
    54. Gao MH, Lai NC, Miyanohara A, Schilling JM, Suarez J, Tang T, Guo T, Tang R, Parikh J, Giamouridis D, Dillmann WH, Patel HH, Roth DM, Dalton ND, Hammond HK. Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice. Hum Gene Ther. 2013 Sep; 24(9):777-85. PMID: 23931341; PMCID: PMC3768340.
    55. Head BP, Patel HH, Insel PA. Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochim Biophys Acta. 2014 Feb; 1838(2):532-45. PMID: 23899502; PMCID: PMC3867519.
    56. Niesman IR, Zemke N, Fridolfsson HN, Haushalter KJ, Levy K, Grove A, Schnoor R, Finley JC, Patel PM, Roth DM, Head BP, Patel HH. Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia. Mol Cell Neurosci. 2013 Sep; 56:283-97. PMID: 23851187; PMCID: PMC3791173.
    57. Panneerselvam M, Ali SS, Finley JC, Kellerhals SE, Migita MY, Head BP, Patel PM, Roth DM, Patel HH. Epicatechin regulation of mitochondrial structure and function is opioid receptor dependent. Mol Nutr Food Res. 2013 Jun; 57(6):1007-14. PMID: 23625721; PMCID: PMC3835714.
    58. Fridolfsson HN, Patel HH. Caveolin and caveolae in age associated cardiovascular disease. J Geriatr Cardiol. 2013 Mar; 10(1):66-74. PMID: 23610576; PMCID: PMC3627709.
    59. Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH, Taylor SS. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. PMID: 23319652; PMCID: PMC3562788.
    60. Pani B, Liu X, Bollimuntha S, Cheng KT, Niesman IR, Zheng C, Achen VR, Patel HH, Ambudkar IS, Singh BB. Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1. J Cell Sci. 2013 Jan 15; 126(Pt 2):667-75. PMID: 23203809; PMCID: PMC3613184.
    61. Stary CM, Tsutsumi YM, Patel PM, Head BP, Patel HH, Roth DM. Caveolins: targeting pro-survival signaling in the heart and brain. Front Physiol. 2012; 3:393. PMID: 23060817; PMCID: PMC3464704.
    62. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. PMID: 22859372; PMCID: PMC4050367.
    63. Tsai CY, Finley JC, Ali SS, Patel HH, Howell SB. Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling. Biochem Pharmacol. 2012 Oct 15; 84(8):1007-13. PMID: 22842628; PMCID: PMC3464187.
    64. Pfleger C, Ebeling G, Bläsche R, Patton M, Patel HH, Kasper M, Barth K. Detection of caveolin-3/caveolin-1/P2X7R complexes in mice atrial cardiomyocytes in vivo and in vitro. Histochem Cell Biol. 2012 Aug; 138(2):231-41. PMID: 22585038; PMCID: PMC3408551.
    65. Pearn ML, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth DM, Akassoglou K, Patel PM, Head BP. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology. 2012 Feb; 116(2):352-61. PMID: 22198221; PMCID: PMC3275822.
    66. Panneerselvam M, Patel HH, Roth DM. Caveolins and heart diseases. Adv Exp Med Biol. 2012; 729:145-56. PMID: 22411319.
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    67. Kawaraguchi Y, Horikawa YT, Murphy AN, Murray F, Miyanohara A, Ali SS, Head BP, Patel PM, Roth DM, Patel HH. Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins. Anesthesiology. 2011 Sep; 115(3):499-508. PMID: 21862885; PMCID: PMC3162469.
    68. Kawaraguchi Y, Roth DM, Patel HH. From local to global: lipid emulsion (intralipid) makes a move. Anesthesiology. 2011 Aug; 115(2):226-8. PMID: 21654493.
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    69. Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM. Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J Biol Chem. 2011 Sep 23; 286(38):33310-21. PMID: 21799010; PMCID: PMC3190943.
    70. Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol. 2011 May 31; 57(22):2273-83. PMID: 21616289; PMCID: PMC3236642.
    71. Panneerselvam M, Patel PM, Roth DM, Kidd MW, Chin-Lee B, Head BP, Niesman IR, Inoue S, Patel HH, Davis DP. Role of decoy molecules in neuronal ischemic preconditioning. Life Sci. 2011 Apr 11; 88(15-16):670-4. PMID: 21315738; PMCID: PMC3070046.
    72. Roth DM, Patel HH. Role of caveolae in cardiac protection. Pediatr Cardiol. 2011 Mar; 32(3):329-33. PMID: 21210089; PMCID: PMC3051068.
    73. Lemkuil BP, Head BP, Pearn ML, Patel HH, Drummond JC, Patel PM. Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology. 2011 Jan; 114(1):49-57. PMID: 21169791; PMCID: PMC3037980.
    74. Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010 Dec 23; 5(12):e15697. PMID: 21203469; PMCID: PMC3009734.
    75. Busija AR, Fridolfsson HN, Patel HH. A new sense of protection: role of the Ca2+-sensing receptor in ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1300-1. PMID: 20852055; PMCID: PMC2993208.
    76. Panneerselvam M, Tsutsumi YM, Bonds JA, Horikawa YT, Saldana M, Dalton ND, Head BP, Patel PM, Roth DM, Patel HH. Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1604-9. PMID: 20833967; PMCID: PMC2993198.
    77. Tsutsumi YM, Kawaraguchi Y, Niesman IR, Patel HH, Roth DM. Opioid-induced preconditioning is dependent on caveolin-3 expression. Anesth Analg. 2010 Nov; 111(5):1117-21. PMID: 20736437; PMCID: PMC3098574.
    78. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem. 2010 Sep 03; 285(36):27632-40. PMID: 20581396; PMCID: PMC2934631.
    79. Tsutsumi YM, Kawaraguchi Y, Horikawa YT, Niesman IR, Kidd MW, Chin-Lee B, Head BP, Patel PM, Roth DM, Patel HH. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. Anesthesiology. 2010 May; 112(5):1136-45. PMID: 20418694; PMCID: PMC2860616.
    80. Cipta S, Patel HH. Molecular bandages: inside-out, outside-in repair of cellular membranes. Focus on "Myoferlin is critical for endocytosis in endothelial cells". Am J Physiol Cell Physiol. 2009 Sep; 297(3):C481-3. PMID: 19587215; PMCID: PMC2740387.
    81. Patel HH, Insel PA. Lipid rafts and caveolae and their role in compartmentation of redox signaling. Antioxid Redox Signal. 2009 Jun; 11(6):1357-72. PMID: 19061440; PMCID: PMC2757136.
    82. Head BP, Patel HH, Niesman IR, Drummond JC, Roth DM, Patel PM. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology. 2009 Apr; 110(4):813-25. PMID: 19293698; PMCID: PMC2767332.
    83. Insel PA, Patel HH. Membrane rafts and caveolae in cardiovascular signaling. Curr Opin Nephrol Hypertens. 2009 Jan; 18(1):50-6. PMID: 19077689; PMCID: PMC2757134.
    84. Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation. 2008 Nov 04; 118(19):1979-88. PMID: 18936328; PMCID: PMC2676165.
    85. Patel HH, Ostrom RS. An orphan GPCR finds a home in the heart. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H479-81. PMID: 18586885.
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    86. Schach C, Firth AL, Xu M, Remillard CV, Patel HH, Insel PA, Yuan JX. Regulation of pulmonary vasoconstriction by agonists and caveolae. Exp Lung Res. 2008 May; 34(4):195-208. PMID: 18432456.
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    87. Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17):6386-91. PMID: 18434542; PMCID: PMC2359804.
    88. Patel HH, Tsutsumi YM, Roth DM. Mito-controversies: mitochondrial permeability transition pore and myocardial reperfusion injury. Anesthesiology. 2008 Feb; 108(2):182-4. PMID: 18212560.
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    89. Patel HH, Murray F, Insel PA. Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol. 2008; 48:359-91. PMID: 17914930; PMCID: PMC3083858.
    90. Horikawa YT, Patel HH, Tsutsumi YM, Jennings MM, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, Roth DM. Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. J Mol Cell Cardiol. 2008 Jan; 44(1):123-30. PMID: 18054955; PMCID: PMC2701396.
    91. Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond JC, Patel PM. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 2008 Mar; 22(3):828-40. PMID: 17905724.
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    92. Swaney JS, Patel HH, Yokoyama U, Lai NC, Spellman M, Insel PA, Roth DM. Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3216-20. PMID: 17873016.
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    93. Tsutsumi YM, Yokoyama T, Horikawa Y, Roth DM, Patel HH. Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization. Life Sci. 2007 Sep 22; 81(15):1223-7. PMID: 17915258; PMCID: PMC2080844.
    94. Feng Z, Davis DP, Sásik R, Patel HH, Drummond JC, Patel PM. Pathway and gene ontology based analysis of gene expression in a rat model of cerebral ischemic tolerance. Brain Res. 2007 Oct 26; 1177:103-23. PMID: 17916339.
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    95. Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 2007 Sep; 21(11):2970-9. PMID: 17470567.
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    96. Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA, Roth DM. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J. 2007 May; 21(7):1565-74. PMID: 17272740.
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    97. Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel PA, Yuan JX. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1202-10. PMID: 17189322.
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    98. Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan JX, Insel PA. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L294-303. PMID: 16980375.
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    99. Sastry A, Arnold E, Gurji H, Iwasa A, Bui H, Hassankhani A, Patel HH, Feramisco JR, Roth DM, Lai NC, Hammond HK, Narayan SM. Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction. J Am Coll Cardiol. 2006 Aug 01; 48(3):559-65. PMID: 16875984.
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    100. Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem. 2006 Sep 08; 281(36):26391-9. PMID: 16818493.
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    101. Tsutsumi YM, Patel HH, Huang D, Roth DM. Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H979-83. PMID: 16648187.
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    102. Swaney JS, Patel HH, Yokoyama U, Head BP, Roth DM, Insel PA. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. J Biol Chem. 2006 Jun 23; 281(25):17173-9. PMID: 16618703.
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    103. Tsutsumi YM, Patel HH, Lai NC, Takahashi T, Head BP, Roth DM. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice. Anesthesiology. 2006 Mar; 104(3):495-502. PMID: 16508397.
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    104. Büscher R, Hoerning A, Patel HH, Zhang S, Arthur DB, Grasemann H, Ratjen F, Insel PA. P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. Pharmacogenet Genomics. 2006 Mar; 16(3):199-205. PMID: 16495779.
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    105. Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel PA, Roth DM. Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H344-50. PMID: 16501018.
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    106. Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem. 2005 Sep 02; 280(35):31036-44. PMID: 15961389.
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    107. Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Ann N Y Acad Sci. 2005 Jun; 1047:166-72. PMID: 16093494.
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    108. Patel HH, Gross ER, Peart JN, Hsu AK, Gross GJ. Sarcolemmal KATP channel triggers delayed ischemic preconditioning in rats. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H445-7. PMID: 15563543.
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    109. Patel HH, Hsu AK, Gross GJ. COX-2 and iNOS in opioid-induced delayed cardioprotection in the intact rat. Life Sci. 2004 May 28; 75(2):129-40. PMID: 15120566.
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    110. Patel HH, Hsu A, Gross GJ. Delayed cardioprotection is mediated via a non-peptide delta opioid agonist, SNC-121, independent of opioid receptor stimulation. Basic Res Cardiol. 2004 Jan; 99(1):38-45. PMID: 14685704.
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    111. Peart JN, Patel HH, Gross GJ. Delta-opioid receptor activation mimics ischemic preconditioning in the canine heart. J Cardiovasc Pharmacol. 2003 Jul; 42(1):78-81. PMID: 12827030.
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    112. Patel HH, Fryer RM, Gross ER, Bundey RA, Hsu AK, Isbell M, Eusebi LO, Jensen RV, Gullans SR, Insel PA, Nithipatikom K, Gross GJ. 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. Circ Res. 2003 Apr 04; 92(6):676-82. PMID: 12623876.
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    113. Ludwig LM, Patel HH, Gross GJ, Kersten JR, Pagel PS, Warltier DC. Morphine enhances pharmacological preconditioning by isoflurane: role of mitochondrial K(ATP) channels and opioid receptors. Anesthesiology. 2003 Mar; 98(3):705-11. PMID: 12606915.
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    114. Patel HH, Moore J, Hsu AK, Gross GJ. Cardioprotection at a distance: mesenteric artery occlusion protects the myocardium via an opioid sensitive mechanism. J Mol Cell Cardiol. 2002 Oct; 34(10):1317-23. PMID: 12392992.
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    115. Patel HH, Hsu AK, Peart JN, Gross GJ. Sarcolemmal K(ATP) channel triggers opioid-induced delayed cardioprotection in the rat. Circ Res. 2002 Aug 09; 91(3):186-8. PMID: 12169643.
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    116. Patel HH, Ludwig LM, Fryer RM, Hsu AK, Warltier DC, Gross GJ. Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening. FASEB J. 2002 Sep; 16(11):1468-70. PMID: 12205051.
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    117. Patel HH, Hsu A, Gross GJ. Attenuation of heat shock-induced cardioprotection by treatment with the opiate receptor antagonist naloxone. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2011-7. PMID: 12003805.
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    118. Patel HH, Gross GJ. The disputed role of COX-2 in myocardial infarction, is the jury still out? J Mol Cell Cardiol. 2002 Jan; 34(1):1-3. PMID: 11812159.
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