Yury Miller

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Russian State Medical University, MoscowMD1984Laboratory Medicine
    Russian State Medical University, MoscowPhD1990Biophysics
    UC San Diego, La Jolla, CApostdoc2001Atherosclerosis

    Collapse Overview 
    Collapse Overview
    The unifying theme in the research program in Miller’s laboratory is the role of lipid metabolism and oxidation in fundamental biologic processes and in development of human disease. The discovery of an oxidized lipoprotein function in activating toll-like receptors (TLRs), made in our lab, has connected lipoprotein metabolism with inflammation in atherosclerosis. We pioneered the use of zebrafish in studying vascular lipid accumulation and inflammation and created new transgenic zebrafish lines with lipid abnormalities and with genetic reporters to detect oxidized lipids. This work led to discoveries of novel functions of lipid and cholesterol metabolism in regulation of vascular and neuro inflammation, neuropathic pain and angiogenesis.

    Collapse Research 
    Collapse Research Activities and Funding
    Reversal of preexisting neuropathic pain by spinal delivery of AIBP
    NIH R33NS104769Aug 1, 2018 - Jul 31, 2021
    Role: Principal Investigator
    Reversal of preexisting neuropathic pain by spinal delivery of AIBP
    NIH R21NS104769Aug 1, 2018 - Jul 31, 2020
    Role: Principal Investigator
    AIBP and regulation of neuropathic pain
    NIH R01NS102432Aug 15, 2017 - May 31, 2022
    Role: Principal Investigator
    AIBP therapy
    NIH R35HL135737Feb 1, 2017 - Jan 31, 2024
    Role: Principal Investigator
    AIBP and Endothelial Function
    NIH R01HL124174Apr 1, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Zebrafish models of vascular inflammation and atherosclerosis
    NIH R01HL093767Jul 1, 2008 - Jun 30, 2016
    Role: Principal Investigator
    Role of Immune Mechanisms in Athersclerosis and Inflammation
    NIH P01HL088093Apr 1, 2007 - Apr 30, 2020
    Role: Co-Investigator
    Early Forms of Oxidized LDL, TLRs and Atherosclerosis
    NIH R01HL081862Apr 1, 2006 - Mar 31, 2012
    Role: Principal Investigator
    Immune Cells in Atherosclerosis and Vascular Disease
    NIH P01HL055798Sep 30, 1995 - Jul 31, 2017
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. J Exp Med. 2021 07 05; 218(7). Navia-Pelaez JM, Choi SH, Dos Santos Aggum Capettini L, Xia Y, Gonen A, Agatisa-Boyle C, Delay L, Gonçalves Dos Santos G, Catroli GF, Kim J, Lu JW, Saylor B, Winkels H, Durant CP, Ghosheh Y, Beaton G, Ley K, Kufareva I, Corr M, Yaksh TL, Miller YI. PMID: 33970188; PMCID: PMC8111462.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    2. Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages. Arterioscler Thromb Vasc Biol. 2021 02; 41(2):e82-e96. Choi SH, Agatisa-Boyle C, Gonen A, Kim A, Kim J, Alekseeva E, Tsimikas S, Miller YI. PMID: 33356389; PMCID: PMC8105271.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    3. From Inert Storage to Biological Activity-In Search of Identity for Oxidized Cholesteryl Esters. Front Endocrinol (Lausanne). 2020; 11:602252. Gonen A, Miller YI. PMID: 33329402; PMCID: PMC7715012.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Targeting Lipid Rafts-A Potential Therapy for COVID-19. Front Immunol. 2020; 11:574508. Sviridov D, Miller YI, Ballout RA, Remaley AT, Bukrinsky M. PMID: 33133090; PMCID: PMC7550455.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    5. AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration. Redox Biol. 2020 10; 37:101703. Choi SH, Kim KY, Perkins GA, Phan S, Edwards G, Xia Y, Kim J, Skowronska-Krawczyk D, Weinreb RN, Ellisman MH, Miller YI, Ju WK. PMID: 32896719; PMCID: PMC7484594.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    6. Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein). Arterioscler Thromb Vasc Biol. 2020 10; 40(10):2346-2359. Low H, Mukhamedova N, Capettini LDSA, Xia Y, Carmichael I, Cody SH, Huynh K, Ditiatkovski M, Ohkawa R, Bukrinsky M, Meikle PJ, Choi SH, Field S, Miller YI, Sviridov D. PMID: 32787522; PMCID: PMC7530101.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    7. Lipid rafts as a therapeutic target. J Lipid Res. 2020 05; 61(5):687-695. Sviridov D, Mukhamedova N, Miller YI. PMID: 32205411; PMCID: PMC7193956.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    8. Erratum for Dubrovsky et al., "Inhibition of HIV Replication by Apolipoprotein A-I Binding Protein Targeting the Lipid Rafts". mBio. 2020 03 17; 11(2). Dubrovsky L, Ward A, Choi SH, Pushkarsky T, Brichacek B, Vanpouille C, Adzhubei AA, Mukhamedova N, Sviridov D, Margolis L, Jones RB, Miller YI, Bukrinsky M. PMID: 32184240; PMCID: PMC7078469.
      View in: PubMed   Mentions:    Fields:    
    9. Inhibition of HIV Replication by Apolipoprotein A-I Binding Protein Targeting the Lipid Rafts. mBio. 2020 01 21; 11(1). Dubrovsky L, Ward A, Choi SH, Pushkarsky T, Brichacek B, Vanpouille C, Adzhubei AA, Mukhamedova N, Sviridov D, Margolis L, Jones RB, Miller YI, Bukrinsky M. PMID: 31964734; PMCID: PMC6974568.
      View in: PubMed   Mentions: 20     Fields:    
    10. Lipid rafts in glial cells: role in neuroinflammation and pain processing. J Lipid Res. 2020 05; 61(5):655-666. Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL. PMID: 31862695; PMCID: PMC7193960.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    11. Erratum: A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. J Lipid Res. 2019 Nov; 60(11):1979. Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. PMID: 31676683; PMCID: PMC6824499.
      View in: PubMed   Mentions:    Fields:    
    12. Biology of Lipid Rafts: Introduction to the Thematic Review Series. J Lipid Res. 2020 05; 61(5):598-600. Sviridov D, Miller YI. PMID: 31462515; PMCID: PMC7193962.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. PLoS Pathog. 2019 07; 15(7):e1007907. Mukhamedova N, Hoang A, Dragoljevic D, Dubrovsky L, Pushkarsky T, Low H, Ditiatkovski M, Fu Y, Ohkawa R, Meikle PJ, Horvath A, Brichacek B, Miller YI, Murphy A, Bukrinsky M, Sviridov D. PMID: 31344124; PMCID: PMC6657916.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    14. Regulation of lipid rafts, angiogenesis and inflammation by AIBP. Curr Opin Lipidol. 2019 06; 30(3):218-223. Fang L, Miller YI. PMID: 30985364; PMCID: PMC6881232.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    15. AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science. 2019 03 08; 363(6431):1085-1088. Gu Q, Yang X, Lv J, Zhang J, Xia B, Kim JD, Wang R, Xiong F, Meng S, Clements TP, Tandon B, Wagner DS, Diaz MF, Wenzel PL, Miller YI, Traver D, Cooke JP, Li W, Zon LI, Chen K, Bai Y, Fang L. PMID: 30705153; PMCID: PMC6469354.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    16. A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. J Lipid Res. 2019 02; 60(2):436-445. Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. PMID: 30563909; PMCID: PMC6358287.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states. Pain. 2018 Oct; 159(10):1908-1915. Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K. PMID: 29889119; PMCID: PMC7890571.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    18. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.
      View in: PubMed   Mentions: 4     Fields:    
    19. AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation. JCI Insight. 2018 08 23; 3(16). Choi SH, Wallace AM, Schneider DA, Burg E, Kim J, Alekseeva E, Ubags ND, Cool CD, Fang L, Suratt BT, Miller YI. PMID: 30135304; PMCID: PMC6141166.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    20. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409; PMCID: PMC6033669.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    21. Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. Cell Rep. 2018 05 29; 23(9):2667-2677. Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI. PMID: 29847797; PMCID: PMC6239868.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    22. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discov. 2018; 4:26. Wang H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, Zhang W, Watson F, Yu V, Liu C, Melo CM, Miller YI, Elliott KC, Cheresh DA, Klemke RL. PMID: 29872538; PMCID: PMC5972149.
      View in: PubMed   Mentions: 9  
    23. Graphene biointerfaces for optical stimulation of cells. Sci Adv. 2018 05; 4(5):eaat0351. Savchenko A, Cherkas V, Liu C, Braun GB, Kleschevnikov A, Miller YI, Molokanova E. PMID: 29795786; PMCID: PMC5959318.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    24. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun. 2018 04 03; 9(1):1310. Liu C, Han T, Stachura DL, Wang H, Vaisman BL, Kim J, Klemke RL, Remaley AT, Rana TM, Traver D, Miller YI. PMID: 29615667; PMCID: PMC5882990.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    25. AIBP protects against metabolic abnormalities and atherosclerosis. J Lipid Res. 2018 05; 59(5):854-863. Schneider DA, Choi SH, Agatisa-Boyle C, Zhu L, Kim J, Pattison J, Sears DD, Gordts PLSM, Fang L, Miller YI. PMID: 29559522; PMCID: PMC5928435.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    26. Palmitate and minimally-modified low-density lipoprotein cooperatively promote inflammatory responses in macrophages. PLoS One. 2018; 13(3):e0193649. Ann SJ, Kim KK, Cheon EJ, Noh HM, Hwang I, Yu JW, Park S, Kang SM, Manabe I, Miller YI, Kim S, Lee SH. PMID: 29518116; PMCID: PMC5843266.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    27. Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish. J Lipid Res. 2018 02; 59(2):391-399. Liu C, Kim YS, Kim J, Pattison J, Kamaid A, Miller YI. PMID: 29187523; PMCID: PMC5794413.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    28. Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux. Autophagy. 2018; 14(1):120-133. Jeong SJ, Kim S, Park JG, Jung IH, Lee MN, Jeon S, Kweon HY, Yu DY, Lee SH, Jang Y, Kang SW, Han KH, Miller YI, Park YM, Cheong C, Choi JH, Oh GT. PMID: 28605287; PMCID: PMC5846566.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    29. Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis. Arterioscler Thromb Vasc Biol. 2017 11; 37(11):2043-2052. Marcovecchio PM, Thomas GD, Mikulski Z, Ehinger E, Mueller KAL, Blatchley A, Wu R, Miller YI, Nguyen AT, Taylor AM, McNamara CA, Ley K, Hedrick CC. PMID: 28935758; PMCID: PMC5930003.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    30. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017 Jun; 14(6):1050-1059. Suratt BT, Ubags NDJ, Rastogi D, Tantisira KG, Marsland BJ, Petrache I, Allen JB, Bates JHT, Holguin F, McCormack MC, Michelakis ED, Black SM, Jain M, Mora AL, Natarajan V, Miller YI, Fessler MB, Birukov KG, Summer RS, Shore SA, Dixon AE, Allergy, Immunology, and Inflammation Assembly. PMID: 28570148; PMCID: PMC5802569.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    31. AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling. Circ Res. 2017 May 26; 120(11):1727-1739. Mao R, Meng S, Gu Q, Araujo-Gutierrez R, Kumar S, Yan Q, Almazan F, Youker KA, Fu Y, Pownall HJ, Cooke JP, Miller YI, Fang L. PMID: 28325782; PMCID: PMC5446274.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    32. Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients. PLoS One. 2017; 12(1):e0169939. Liu C, Gaudet D, Miller YI. PMID: 28107429; PMCID: PMC5249157.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    33. Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation. Trends Endocrinol Metab. 2017 02; 28(2):143-152. Miller YI, Shyy JY. PMID: 27931771; PMCID: PMC5253098.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    34. Ins and outs of the ATP-binding cassette transporter A1. Curr Opin Lipidol. 2016 08; 27(4):429-30. Sviridov D, Miller YI. PMID: 27383285.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Oxidized cholesteryl esters and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Apr; 1862(4):393-397. Choi SH, Sviridov D, Miller YI. PMID: 27368140; PMCID: PMC5199681.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    36. Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results. J Lipid Res. 2016 Apr; 57(4):706-13. Yang X, Lee SR, Choi YS, Alexander VJ, Digenio A, Yang Q, Miller YI, Witztum JL, Tsimikas S. PMID: 26848137; PMCID: PMC4808774.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCTClinical Trials
    37. MD-2 binds cholesterol. Biochem Biophys Res Commun. 2016 Feb 19; 470(4):877-80. Choi SH, Kim J, Gonen A, Viriyakosol S, Miller YI. PMID: 26806306; PMCID: PMC4915372.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    38. Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. Dis Model Mech. 2015 Aug 01; 8(8):989-98. Liu C, Gates KP, Fang L, Amar MJ, Schneider DA, Geng H, Huang W, Kim J, Pattison J, Zhang J, Witztum JL, Remaley AT, Dong PD, Miller YI. PMID: 26044956; PMCID: PMC4527288.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    39. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015 Aug 15; 404(2):49-60. Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC. PMID: 26004360; PMCID: PMC4515213.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    40. SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL. Autophagy. 2015; 11(5):785-95. Choi SH, Gonen A, Diehl CJ, Kim J, Almazan F, Witztum JL, Miller YI. PMID: 25946330; PMCID: PMC4509444.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    41. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 2015 Mar 03; 131(9):805-14. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY. PMID: 25550450; PMCID: PMC4351177.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    42. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One. 2014; 9(9):e107658. Lazic M, Inzaugarat ME, Povero D, Zhao IC, Chen M, Nalbandian M, Miller YI, Cherñavsky AC, Feldstein AE, Sears DD. PMID: 25251155; PMCID: PMC4175074.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    43. Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis. Circ Res. 2014 May 09; 114(10):1576-84. Ai D, Jiang H, Westerterp M, Murphy AJ, Wang M, Ganda A, Abramowicz S, Welch C, Almazan F, Zhu Y, Miller YI, Tall AR. PMID: 24687132; PMCID: PMC4058053.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    44. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. J Am Coll Cardiol. 2014 May 20; 63(19):1961-71. Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum JL, Tsimikas S. PMID: 24613321; PMCID: PMC4629781.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    45. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. PLoS One. 2013; 8(12):e83145. Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller YI. PMID: 24376657; PMCID: PMC3871536.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    46. Zebrafish models of dyslipidemia: relevance to atherosclerosis and angiogenesis. Transl Res. 2014 Feb; 163(2):99-108. Fang L, Liu C, Miller YI. PMID: 24095954; PMCID: PMC3946603.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    47. Oxidation-specific epitopes as targets for biotheranostic applications in humans: biomarkers, molecular imaging and therapeutics. Curr Opin Lipidol. 2013 Oct; 24(5):426-37. Miller YI, Tsimikas S. PMID: 23995232; PMCID: PMC4085330.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    48. Targeted cholesterol efflux. Cell Cycle. 2013 Nov 01; 12(21):3345-6. Fang L, Miller YI. PMID: 24036659; PMCID: PMC3895418.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    49. Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature. 2013 Jun 06; 498(7452):118-22. Fang L, Choi SH, Baek JS, Liu C, Almazan F, Ulrich F, Wiesner P, Taleb A, Deer E, Pattison J, Torres-Vázquez J, Li AC, Miller YI. PMID: 23719382; PMCID: PMC3760669.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    50. MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. J Lipid Res. 2013 Jul; 54(7):1877-83. Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI. PMID: 23667177; PMCID: PMC3679389.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    51. The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL. Br J Pharmacol. 2012 Nov; 167(5):990-9. Miller YI, Choi SH, Wiesner P, Bae YS. PMID: 22776094; PMCID: PMC3492981.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    52. Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis. J Clin Invest. 2012 Sep; 122(9):3114-26. Koltsova EK, Garcia Z, Chodaczek G, Landau M, McArdle S, Scott SR, von Vietinghoff S, Galkina E, Miller YI, Acton ST, Ley K. PMID: 22886300; PMCID: PMC3428082.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    53. Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids. Free Radic Biol Med. 2012 Oct 01; 53(7):1411-20. Fang L, Miller YI. PMID: 22906686; PMCID: PMC3448821.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    54. Ezetimibe and simvastatin reduce cholesterol levels in zebrafish larvae fed a high-cholesterol diet. Cholesterol. 2012; 2012:564705. Baek JS, Fang L, Li AC, Miller YI. PMID: 22693663; PMCID: PMC3369394.
      View in: PubMed   Mentions: 23  
    55. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab. 2012 Apr 04; 15(4):554-62. Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, Miller YI, Witztum JL, Melnick AM, Dent AL, Tangirala RK, Evans RM. PMID: 22465074; PMCID: PMC3367511.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    56. Spleen tyrosine kinase regulates AP-1 dependent transcriptional response to minimally oxidized LDL. PLoS One. 2012; 7(2):e32378. Choi SH, Wiesner P, Almazan F, Kim J, Miller YI. PMID: 22384232; PMCID: PMC3284564.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    57. Palmitate promotes the paracrine effects of macrophages on vascular smooth muscle cells: the role of bone morphogenetic proteins. PLoS One. 2012; 7(2):e29100. Chung JH, Jeon HJ, Hong SY, Lee DL, Lee KH, Kim SH, Han YS, Manabe I, Miller YI, Lee SH. PMID: 22363399; PMCID: PMC3283596.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    58. In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probes. J Am Coll Cardiol. 2012 Feb 07; 59(6):616-26. Briley-Saebo KC, Nguyen TH, Saeboe AM, Cho YS, Ryu SK, Volkova ER, Volkava E, Dickson S, Leibundgut G, Wiesner P, Weisner P, Green S, Casanada F, Miller YI, Shaw W, Witztum JL, Fayad ZA, Tsimikas S. PMID: 22300697; PMCID: PMC3333483.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    59. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. J Clin Invest. 2011 Dec; 121(12):4861-9. Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, Lieschke GJ, Witztum JL, Tsimikas S, Miller YI. PMID: 22105168; PMCID: PMC3225997.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    60. Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol. 2011 Jul; 31(7):1506-16. Ley K, Miller YI, Hedrick CC. PMID: 21677293; PMCID: PMC3133596.
      View in: PubMed   Mentions: 252     Fields:    Translation:HumansAnimalsCells
    61. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21; 108(2):235-48. Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. PMID: 21252151; PMCID: PMC3075542.
      View in: PubMed   Mentions: 301     Fields:    Translation:HumansAnimalsCells
    62. Oxidative modification of lipoproteins: mechanisms, role in inflammation and potential clinical applications in cardiovascular disease. Curr Pharm Des. 2011; 17(1):27-37. Tsimikas S, Miller YI. PMID: 21226665.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    63. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. J Biol Chem. 2010 Oct 15; 285(42):32343-51. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. PMID: 20710028; PMCID: PMC2952235.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    64. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 09; 107(1):56-65. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. PMID: 20489162; PMCID: PMC2904601.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    65. Lipoprotein modification and macrophage uptake: role of pathologic cholesterol transport in atherogenesis. Subcell Biochem. 2010; 51:229-51. Miller YI, Choi SH, Fang L, Tsimikas S. PMID: 20213546.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    66. Toll-like receptor-4 and lipoprotein accumulation in macrophages. Trends Cardiovasc Med. 2009 Oct; 19(7):227-32. Miller YI, Choi SH, Fang L, Harkewicz R. PMID: 20382346; PMCID: PMC2854673.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    67. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One. 2009 Sep 29; 4(9):e7250. Sears DD, Miles PD, Chapman J, Ofrecio JM, Almazan F, Thapar D, Miller YI. PMID: 19787041; PMCID: PMC2746280.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    68. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res. 2009 Jun 19; 104(12):1355-63. Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, Li AC, Witztum JL, Bae YS, Miller YI. PMID: 19461045; PMCID: PMC2741301.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    69. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May; 119(5):1335-49. Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. PMID: 19363291; PMCID: PMC2673862.
      View in: PubMed   Mentions: 246     Fields:    Translation:AnimalsCells
    70. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res. 2009 Apr 24; 104(8):952-60. Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI. PMID: 19265037; PMCID: PMC2834250.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    71. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res. 2009 Jan 30; 104(2):210-8, 21p following 218. Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI. PMID: 19096031; PMCID: PMC2720065.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    72. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. J Biol Chem. 2008 Apr 18; 283(16):10241-51. Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. PMID: 18263582; PMCID: PMC2447632.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    73. A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2096-102. Tuominen A, Miller YI, Hansen LF, Kesäniemi YA, Witztum JL, Hörkkö S. PMID: 16794225.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    74. Insulin and glucose play a role in foam cell formation and function. Cardiovasc Diabetol. 2006 Jun 20; 5:13. Shashkin PN, Jain N, Miller YI, Rissing BA, Huo Y, Keller SR, Vandenhoff GE, Nadler JL, McIntyre TM. PMID: 16787541; PMCID: PMC1550220.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    75. The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK. J Immunol. 2006 Jun 15; 176(12):7412-20. Green SR, Han KH, Chen Y, Almazan F, Charo IF, Miller YI, Quehenberger O. PMID: 16751386.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    76. Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):1169-76. Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum JL, Miller YI. PMID: 16484596.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    77. Toll-like receptors and atherosclerosis: oxidized LDL as an endogenous Toll-like receptor ligand. Future Cardiol. 2005 Nov; 1(6):785-92. Miller YI. PMID: 19804052.
      View in: PubMed   Mentions: 20     Fields:    
    78. Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis. J Lipid Res. 2005 Sep; 46(9):1849-59. Zeng X, Chen J, Miller YI, Javaherian K, Moulton KS. PMID: 15995169.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    79. The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul; 46(7):1353-63. Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum JL. PMID: 15897601.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    80. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol. 2005 Jun; 25(6):1213-9. Miller YI, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum JL. PMID: 15718493.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    81. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med. 2004 Dec 06; 200(11):1359-70. Chang MK, Binder CJ, Miller YI, Subbanagounder G, Silverman GJ, Berliner JA, Witztum JL. PMID: 15583011; PMCID: PMC2211955.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    82. Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol. 2003 Oct; 14(5):437-45. Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum JL. PMID: 14501582.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    83. Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell. 2003 Oct; 14(10):4196-206. Miller YI, Worrall DS, Funk CD, Feramisco JR, Witztum JL. PMID: 14517329; PMCID: PMC207011.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    84. Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov; 8(11):1218-26. Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum JL. PMID: 12411948.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansAnimalsCells
    85. 12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells. J Biol Chem. 2001 Jun 01; 276(22):19431-9. Miller YI, Chang MK, Funk CD, Feramisco JR, Witztum JL. PMID: 11278875.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    86. Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation. Biochim Biophys Acta. 1999 Jul 07; 1454(2):153-64. Miller YI, Shaklai N. PMID: 10381560.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    87. A fluorescence method for estimation of toxemia: binding capacity of lipoproteins and albumin in plasma. Clin Chim Acta. 1998 Mar 23; 271(2):133-49. Altamentova SM, Shaklai N, Arav R, Miller YI. PMID: 9565329.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    88. Oxidation of low-density lipoprotein by hemoglobin stems from a heme-initiated globin radical: antioxidant role of haptoglobin. Biochemistry. 1997 Oct 07; 36(40):12189-98. Miller YI, Altamentova SM, Shaklai N. PMID: 9315856.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    89. Role of hemopexin in protection of low-density lipoprotein against hemoglobin-induced oxidation. Biochemistry. 1996 Oct 08; 35(40):13112-7. Miller YI, Smith A, Morgan WT, Shaklai N. PMID: 8855948.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    90. Hemoglobin induced apolipoprotein B crosslinking in low-density lipoprotein peroxidation. Arch Biochem Biophys. 1996 Feb 15; 326(2):252-60. Miller YI, Felikman Y, Shaklai N. PMID: 8611031.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    91. The involvement of low-density lipoprotein in hemin transport potentiates peroxidative damage. Biochim Biophys Acta. 1995 Oct 17; 1272(2):119-27. Miller YI, Felikman Y, Shaklai N. PMID: 7548235.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    92. Oxidative crosslinking of LDL protein induced by hemin: involvement of tyrosines. Biochem Mol Biol Int. 1994 Dec; 34(6):1121-9. Miller YI, Shaklai N. PMID: 7696984.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
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