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Alexis Komor

Title(s)Assistant Professor, Chemistry and Biochemistry
SchoolAcademic Aff
Address9500 Gilman Drive #0314
La Jolla CA 92093
Phone858-246-2608
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of New Genome Editing Agents Using RNA Modifying Enzymes
    NIH/NIGMS R21GM135736Sep 20, 2019 - Aug 31, 2021
    Role: Principal Investigator
    Development and validation of a precision genome editing platform
    NIH/NIGMS F32GM112366Apr 1, 2015 - Mar 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors. Sci Adv. 2020 03; 6(10):eaaz2309. Rallapalli KL, Komor AC, Paesani F. PMID: 32181363.
      View in: PubMed   Mentions:    Fields:    
    2. Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 03; 579(7797):123-129. Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. PMID: 32103176.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    3. Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. Genes (Basel). 2020 01 12; 11(1). Fox K, Rallapalli KL, Komor AC. PMID: 31940934.
      View in: PubMed   Mentions: 1     Fields:    
    4. Base Editors: Modular Tools for the Introduction of Point Mutations in Living Cells. Emerg Top Life Sci. 2019 11; 3(5):483-491. Evanoff M, Komor AC. PMID: 32270050.
      View in: PubMed   Mentions:
    5. The Beginning of Base Editing: An Interview with Alexis C. Komor and Nicole M. Gaudelli. CRISPR J. 2019 04; 2:81-90. Davies K, Komor AC, Gaudelli NM. PMID: 30998094.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells. Biochemistry. 2019 02 05; 58(5):330-335. Ranzau BL, Komor AC. PMID: 30500171.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. 2018 07; 559(7714):E8. Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. PMID: 29720650.
      View in: PubMed   Mentions: 2     Fields:    
    8. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. 2017 11 23; 551(7681):464-471. Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. PMID: 29160308.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    9. Editing the Genome Without Double-Stranded DNA Breaks. ACS Chem Biol. 2018 02 16; 13(2):383-388. Komor AC, Badran AH, Liu DR. PMID: 28957631.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    10. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci Adv. 2017 08; 3(8):eaao4774. Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR. PMID: 28875174.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    11. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nat Commun. 2017 06 06; 8:15790. Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. PMID: 28585549.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    12. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell. 2017 04 20; 169(3):559. Komor AC, Badran AH, Liu DR. PMID: 28431253.
      View in: PubMed   Mentions: 25     Fields:    
    13. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions. Nat Biotechnol. 2017 04; 35(4):371-376. Kim YB, Komor AC, Levy JM, Packer MS, Zhao KT, Liu DR. PMID: 28191901.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    14. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell. 2017 Jan 12; 168(1-2):20-36. Komor AC, Badran AH, Liu DR. PMID: 27866654.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    15. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature. 2016 05 19; 533(7603):420-4. Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. PMID: 27096365.
      View in: PubMed   Mentions: 286     Fields:    Translation:HumansAnimalsCells
    16. An unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency. J Am Chem Soc. 2014 Oct 08; 136(40):14160-72. Komor AC, Barton JK. PMID: 25254630.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Targeted Chemotherapy with Metal Complexes. Comments Mod Chem A Comments Inorg Chem. 2014 May; 34(3-4):114-123. Weidmann AG, Komor AC, Barton JK. PMID: 25642012.
      View in: PubMed   Mentions:
    18. An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency. PLoS One. 2013; 8(10):e78726. Bailis JM, Gordon ML, Gurgel JL, Komor AC, Barton JK, Kirsch IR. PMID: 24205301.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. Biological effects of simple changes in functionality on rhodium metalloinsertors. Philos Trans A Math Phys Eng Sci. 2013 Jul 28; 371(1995):20120117. Weidmann AG, Komor AC, Barton JK. PMID: 23776288.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    20. The path for metal complexes to a DNA target. Chem Commun (Camb). 2013 May 07; 49(35):3617-30. Komor AC, Barton JK. PMID: 23423158.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    21. Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localization. J Am Chem Soc. 2012 Nov 21; 134(46):19223-33. Komor AC, Schneider CJ, Weidmann AG, Barton JK. PMID: 23137296.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    22. Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells. Biochemistry. 2011 Dec 20; 50(50):10919-28. Ernst RJ, Komor AC, Barton JK. PMID: 22103240.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. A hydrogen-bond facilitated cycle for oxygen reduction by an acid- and base-compatible iron platform. Inorg Chem. 2009 Nov 02; 48(21):10024-35. Soo HS, Komor AC, Iavarone AT, Chang CJ. PMID: 19780564.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
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