Alexis Komor

Title(s)Associate Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Development and Application of New Genome Editing Tools for the Functional Investigation of Genetic Variants of Uncertain Significance
    NIH R35GM138317Sep 1, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Development of New Genome Editing Agents Using RNA Modifying Enzymes
    NIH R21GM135736Sep 20, 2019 - Aug 31, 2021
    Role: Principal Investigator
    Development and validation of a precision genome editing platform
    NIH F32GM112366Apr 1, 2015 - Mar 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Impact of CRISPR in cancer drug discovery. Science. 2024 Oct 25; 386(6720):378-379. Moffat J, Komor AC, Lum L. PMID: 39446947.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Genome editing with DNA-dependent polymerases. Nat Biotechnol. 2024 Aug 23. Cowan QT, Komor AC. PMID: 39179922.
      View in: PubMed   Mentions:    Fields:    
    3. Development of multiplexed orthogonal base editor (MOBE) systems. Nat Biotechnol. 2024 May 21. Cowan QT, Gu S, Gu W, Ranzau BL, Simonson TS, Komor AC. PMID: 38773305; PMCID: PMC11579250.
      View in: PubMed   Mentions: 2     Fields:    
    4. Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders. Sci Adv. 2024 Feb 09; 10(6):eadj5661. Lawrence ES, Gu W, Bohlender RJ, Anza-Ramirez C, Cole AM, Yu JJ, Hu H, Heinrich EC, O'Brien KA, Vasquez CA, Cowan QT, Bruck PT, Mercader K, Alotaibi M, Long T, Hall JE, Moya EA, Bauk MA, Reeves JJ, Kong MC, Salem RM, Vizcardo-Galindo G, Macarlupu JL, Figueroa-Mujíca R, Bermudez D, Corante N, Gaio E, Fox KP, Salomaa V, Havulinna AS, Murray AJ, Malhotra A, Powel FL, Jain M, Komor AC, Cavalleri GL, Huff CD, Villafuerte FC, Simonson TS. PMID: 38335297; PMCID: PMC10857371.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    5. Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies. Nat Commun. 2024 Jan 29; 15(1):875. Medina-Munoz HC, Kofman E, Jagannatha P, Boyle EA, Yu T, Jones KL, Mueller JR, Lykins GD, Doudna AT, Park SS, Blue SM, Ranzau BL, Kohli RM, Komor AC, Yeo GW. PMID: 38287010; PMCID: PMC10825223.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    6. Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies. bioRxiv. 2023 Sep 25. Medina-Munoz HC, Kofman E, Jagannatha P, Boyle EA, Yu T, Jones KL, Mueller JR, Lykins GD, Doudna AT, Park SS, Blue SM, Ranzau BL, Kohli RM, Komor AC, Yeo GW. PMID: 37808757; PMCID: PMC10557582.
      View in: PubMed   Mentions:
    7. The Wild-Type tRNA Adenosine Deaminase Enzyme TadA Is Capable of Sequence-Specific DNA Base Editing. Chembiochem. 2023 08 15; 24(16):e202200788. Ranzau BL, Rallapalli KL, Evanoff M, Paesani F, Komor AC. PMID: 36947856; PMCID: PMC10514239.
      View in: PubMed   Mentions: 2     Fields:    
    8. Curing "GFP-itis" in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students. CRISPR J. 2023 06; 6(3):186-195. Vasquez CA, Evanoff M, Ranzau BL, Gu S, Deters E, Komor AC. PMID: 37083425; PMCID: PMC10277996.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. In the business of base editors: Evolution from bench to bedside. PLoS Biol. 2023 04; 21(4):e3002071. Porto EM, Komor AC. PMID: 37043430; PMCID: PMC10096463.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    10. The Design and Application of DNA-Editing Enzymes as Base Editors. Annu Rev Biochem. 2023 06 20; 92:43-79. Rallapalli KL, Komor AC. PMID: 37018843; PMCID: PMC10330504.
      View in: PubMed   Mentions: 6     Fields:    
    11. Curing "GFP-itis" in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students. bioRxiv. 2023 Feb 07. Vasquez CA, Evanoff M, Ranzau BL, Gu S, Deters E, Komor AC. PMID: 36798336; PMCID: PMC9934571.
      View in: PubMed   Mentions:
    12. Examination of the Cell Cycle Dependence of Cytosine and Adenine Base Editors. Front Genome Ed. 2022; 4:923718. Burnett CA, Wong AT, Vasquez CA, McHugh CA, Yeo GW, Komor AC. PMID: 35910415; PMCID: PMC9333457.
      View in: PubMed   Mentions: 2  
    13. Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles. Nat Commun. 2022 May 09; 13(1):2595. Bishop AL, López Del Amo V, Okamoto EM, Bodai Z, Komor AC, Gantz VM. PMID: 35534475; PMCID: PMC9085836.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. Targeting double-strand break indel byproducts with secondary guide RNAs improves Cas9 HDR-mediated genome editing efficiencies. Nat Commun. 2022 05 09; 13(1):2351. Bodai Z, Bishop AL, Gantz VM, Komor AC. PMID: 35534455; PMCID: PMC9085776.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    15. The use of base editing technology to characterize single nucleotide variants. Comput Struct Biotechnol J. 2022; 20:1670-1680. McDaniel S, Komor A, Goren A. PMID: 35465164; PMCID: PMC9010703.
      View in: PubMed   Mentions: 2  
    16. Combined Theoretical, Bioinformatic, and Biochemical Analyses of RNA Editing by Adenine Base Editors. CRISPR J. 2022 04; 5(2):294-310. Rallapalli KL, Ranzau BL, Ganapathy KR, Paesani F, Komor AC. PMID: 35353638; PMCID: PMC9347300.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    17. CRISPR-derived genome editing therapies: Progress from bench to bedside. Mol Ther. 2021 Nov 03; 29(11):3125-3139. Rees HA, Minella AC, Burnett CA, Komor AC, Gaudelli NM. PMID: 34619370; PMCID: PMC8572140.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. Single-base editing of rs12603332 on chromosome 17q21 with a cytosine base editor regulates ORMDL3 and ATF6α expression. Allergy. 2022 04; 77(4):1139-1149. Weng N, Miller M, Pham AK, Komor AC, Broide DH. PMID: 34525218; PMCID: PMC8920947.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. Base Editors: Expanding the Types of DNA Damage Products Harnessed for Genome Editing. Gene Genome Ed. 2021 Jun; 1. Gu S, Bodai Z, Cowan QT, Komor AC. PMID: 34368792; PMCID: PMC8341163.
      View in: PubMed   Mentions: 13  
    20. Base Editing in Human Cells to Produce Single-Nucleotide-Variant Clonal Cell Lines. Curr Protoc Mol Biol. 2020 12; 133(1):e129. Vasquez CA, Cowan QT, Komor AC. PMID: 33151638; PMCID: PMC7654285.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Celebrating Rosalind Franklin's Centennial with a Nobel Win for Doudna and Charpentier. Mol Ther. 2020 12 02; 28(12):2519-2520. Gaudelli NM, Komor AC. PMID: 33181064; PMCID: PMC7704750.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    22. Base editing: advances and therapeutic opportunities. Nat Rev Drug Discov. 2020 12; 19(12):839-859. Porto EM, Komor AC, Slaymaker IM, Yeo GW. PMID: 33077937; PMCID: PMC7721651.
      View in: PubMed   Mentions: 153     Fields:    Translation:Humans
    23. Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors. Sci Adv. 2020 03; 6(10):eaaz2309. Rallapalli KL, Komor AC, Paesani F. PMID: 32181363; PMCID: PMC7056309.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    24. Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 03; 579(7797):123-129. Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. PMID: 32103176; PMCID: PMC7252668.
      View in: PubMed   Mentions: 206     Fields:    Translation:HumansAnimals
    25. Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. Genes (Basel). 2020 01 12; 11(1). Fox K, Rallapalli KL, Komor AC. PMID: 31940934; PMCID: PMC7016644.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. Base Editors: Modular Tools for the Introduction of Point Mutations in Living Cells. Emerg Top Life Sci. 2019 Nov; 3(5):483-491. Evanoff M, Komor AC. PMID: 32270050; PMCID: PMC7141416.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    27. The Beginning of Base Editing: An Interview with Alexis C. Komor and Nicole M. Gaudelli. CRISPR J. 2019 04; 2:81-90. Davies K, Komor AC, Gaudelli NM. PMID: 30998094.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells. Biochemistry. 2019 02 05; 58(5):330-335. Ranzau BL, Komor AC. PMID: 30500171; PMCID: PMC6720104.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    29. Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. 2018 07; 559(7714):E8. Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. PMID: 29720650.
      View in: PubMed   Mentions: 13     Fields:    
    30. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. 2017 11 23; 551(7681):464-471. Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. PMID: 29160308; PMCID: PMC5726555.
      View in: PubMed   Mentions: 1666     Fields:    Translation:HumansCells
    31. Editing the Genome Without Double-Stranded DNA Breaks. ACS Chem Biol. 2018 02 16; 13(2):383-388. Komor AC, Badran AH, Liu DR. PMID: 28957631; PMCID: PMC5891729.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    32. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci Adv. 2017 08; 3(8):eaao4774. Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR. PMID: 28875174; PMCID: PMC5576876.
      View in: PubMed   Mentions: 366     Fields:    Translation:HumansCells
    33. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nat Commun. 2017 06 06; 8:15790. Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. PMID: 28585549; PMCID: PMC5467206.
      View in: PubMed   Mentions: 210     Fields:    Translation:AnimalsCells
    34. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell. 2017 04 20; 169(3):559. Komor AC, Badran AH, Liu DR. PMID: 28431253.
      View in: PubMed   Mentions: 107     Fields:    
    35. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions. Nat Biotechnol. 2017 04; 35(4):371-376. Kim YB, Komor AC, Levy JM, Packer MS, Zhao KT, Liu DR. PMID: 28191901; PMCID: PMC5388574.
      View in: PubMed   Mentions: 377     Fields:    Translation:Cells
    36. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell. 2017 Jan 12; 168(1-2):20-36. Komor AC, Badran AH, Liu DR. PMID: 27866654; PMCID: PMC5235943.
      View in: PubMed   Mentions: 403     Fields:    Translation:HumansAnimalsCells
    37. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature. 2016 May 19; 533(7603):420-4. Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. PMID: 27096365; PMCID: PMC4873371.
      View in: PubMed   Mentions: 2120     Fields:    Translation:HumansAnimalsCells
    38. An unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency. J Am Chem Soc. 2014 Oct 08; 136(40):14160-72. Komor AC, Barton JK. PMID: 25254630; PMCID: PMC4195389.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    39. Targeted Chemotherapy with Metal Complexes. Comments Mod Chem A Comments Inorg Chem. 2014 May; 34(3-4):114-123. Weidmann AG, Komor AC, Barton JK. PMID: 25642012; PMCID: PMC4309285.
      View in: PubMed   Mentions: 13  
    40. An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency. PLoS One. 2013; 8(10):e78726. Bailis JM, Gordon ML, Gurgel JL, Komor AC, Barton JK, Kirsch IR. PMID: 24205301; PMCID: PMC3812133.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    41. Biological effects of simple changes in functionality on rhodium metalloinsertors. Philos Trans A Math Phys Eng Sci. 2013 Jul 28; 371(1995):20120117. Weidmann AG, Komor AC, Barton JK. PMID: 23776288; PMCID: PMC3685451.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    42. The path for metal complexes to a DNA target. Chem Commun (Camb). 2013 May 07; 49(35):3617-30. Komor AC, Barton JK. PMID: 23423158; PMCID: PMC3660861.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    43. Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localization. J Am Chem Soc. 2012 Nov 21; 134(46):19223-33. Komor AC, Schneider CJ, Weidmann AG, Barton JK. PMID: 23137296; PMCID: PMC3740518.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    44. Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells. Biochemistry. 2011 Dec 20; 50(50):10919-28. Ernst RJ, Komor AC, Barton JK. PMID: 22103240; PMCID: PMC3364161.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    45. A hydrogen-bond facilitated cycle for oxygen reduction by an acid- and base-compatible iron platform. Inorg Chem. 2009 Nov 02; 48(21):10024-35. Soo HS, Komor AC, Iavarone AT, Chang CJ. PMID: 19780564.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
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