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Alessandra Franco

Title(s)Associate Adjunct Professor, Pediatrics
SchoolHealth Sciences
Phone858-246-0160
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    Collapse Research 
    Collapse Research Activities and Funding
    How immunodominant Fc peptide epitopes expand natural regulatory T cells and downregulate inflammation
    NIH/NIAID R01AI143586Jan 23, 2019 - Dec 31, 2021
    Role: Principal Investigator
    Impact of TNFa blockade on immune function in acute Kawasaki disease
    NIH/NHLBI R01HL103536Apr 15, 2010 - Feb 28, 2015
    Role: Principal Investigator
    GENERATION OF THOMSEN-FREIDENREICH-SPECIFIC T CELLS
    NIH/NCI R29CA078657Jul 1, 1998 - Aug 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shimizu C, Kim J, Eleftherohorinou H, Wright VJ, Hoang LT, Tremoulet AH, Franco A, Hibberd ML, Takahashi A, Kubo M, Ito K, Tanaka T, Onouchi Y, Coin LJM, Levin M, Burns JC, Shike H. HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease. Hum Immunol. 2019 May 20. PMID: 31122742.
      View in: PubMed
    2. Franco A, Kumar J, Lin G, Behnamfar N, Hsieh LE, Shimizu C, Tremoulet AH, Burns JC, Linden J. Pediatric tolerogenic DCs expressing CD4 and immunoglobulin-like transcript receptor (ILT)-4 secrete IL-10 in response to Fc and adenosine. Eur J Immunol. 2018 03; 48(3):482-491. PMID: 29244203.
      View in: PubMed
    3. Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E. The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. Gut. 2017 09; 66(9):1584-1596. PMID: 27325418.
      View in: PubMed
    4. Tremoulet AH, Jain S, Kim S, Newburger J, Arditi M, Franco A, Best B, Burns JC. Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial). Contemp Clin Trials. 2016 05; 48:70-5. PMID: 27080929.
      View in: PubMed
    5. Franco A. Introduction. Autoimmunity. 2015 May; 48(3):137-8. PMID: 25831239.
      View in: PubMed
    6. Burns JC, Touma R, Song Y, Padilla RL, Tremoulet AH, Sidney J, Sette A, Franco A. Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease. Autoimmunity. 2015 May; 48(3):181-8. PMID: 25822882; PMCID: PMC4784966.
    7. Burns JC, Franco A. The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease. Expert Rev Clin Immunol. 2015; 11(7):819-25. PMID: 26099344; PMCID: PMC4985263.
    8. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. PMID: 25282159.
      View in: PubMed
    9. Franco A, Touma R, Song Y, Shimizu C, Tremoulet AH, Kanegaye JT, Burns JC. Specificity of regulatory T cells that modulate vascular inflammation. Autoimmunity. 2014 Mar; 47(2):95-104. PMID: 24490882.
      View in: PubMed
    10. Ogata S, Shimizu C, Franco A, Touma R, Kanegaye JT, Choudhury BP, Naidu NN, Kanda Y, Hoang LT, Hibberd ML, Tremoulet AH, Varki A, Burns JC. Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G. PLoS One. 2013; 8(12):e81448. PMID: 24324693.
      View in: PubMed
    11. Shimizu C, Oharaseki T, Takahashi K, Kottek A, Franco A, Burns JC. The role of TGF-ß and myofibroblasts in the arteritis of Kawasaki disease. Hum Pathol. 2013 Feb; 44(2):189-98. PMID: 22955109; PMCID: PMC3518690.
    12. Tremoulet AH, Pancoast P, Franco A, Bujold M, Shimizu C, Onouchi Y, Tamamoto A, Erdem G, Dodd D, Burns JC. Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr. 2012 Sep; 161(3):506-512.e1. PMID: 22484354; PMCID: PMC3613150.
    13. Franco A, Almanza G, Burns JC, Wheeler M, Zanetti M. Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones. Cell Immunol. 2010; 266(1):1-6. PMID: 20951371.
      View in: PubMed
    14. Franco A, Shimizu C, Tremoulet AH, Burns JC. Memory T-cells and characterization of peripheral T-cell clones in acute Kawasaki disease. Autoimmunity. 2010 Jun; 43(4):317-24. PMID: 20166878; PMCID: PMC2871072.
    15. Franco A. Glycoconjugates as vaccines for cancer immunotherapy: clinical trials and future directions. Anticancer Agents Med Chem. 2008 Jan; 8(1):86-91. PMID: 18220508.
      View in: PubMed
    16. Franco A, Albani S. Translating the concept of suppressor/regulatory T cells to clinical applications. Int Rev Immunol. 2006 Jan-Apr; 25(1-2):27-47. PMID: 16669133.
      View in: PubMed