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Nicole Scharping

Title(s)Postdoctoral Scholar, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #NULL
La Jolla CA 92093
Phone000-000-NULL
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    Collapse Research 
    Collapse Research Activities and Funding
    Tumor-infiltrating T cell metabolic dysfunction and genetic reprogramming for effective immunotherapy
    NIH/NCI K00CA222711Mar 1, 2020 - Feb 29, 2024
    Role: Principal Investigator
    Tumor-infiltrating T cell metabolic dysfunction and genetic reprogramming for effective immunotherapy
    NIH/NCI F99CA222711Sep 14, 2017 - Aug 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell. Cancer Immunol Res. 2019 08; 7(8):1258-1266. Shao L, Hou W, Scharping NE, Vendetti FP, Srivastava R, Roy CN, Menk AV, Wang Y, Chauvin JM, Karukonda P, Thorne SH, Hornung V, Zarour HM, Bakkenist CJ, Delgoffe GM, Sarkar SN. PMID: 31239318.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses. J Exp Med. 2018 04 02; 215(4):1091-1100. Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM. PMID: 29511066.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    3. Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions. Cell Rep. 2018 02 06; 22(6):1509-1521. Menk AV, Scharping NE, Moreci RS, Zeng X, Guy C, Salvatore S, Bae H, Xie J, Young HA, Wendell SG, Delgoffe GM. PMID: 29425506.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    4. Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia. Cancer Immunol Res. 2017 01; 5(1):9-16. Scharping NE, Menk AV, Whetstone RD, Zeng X, Delgoffe GM. PMID: 27941003.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    5. Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity. Vaccines (Basel). 2016 Dec 06; 4(4). Scharping NE, Delgoffe GM. PMID: 27929420.
      View in: PubMed   Mentions:
    6. Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation. J Immunol. 2016 12 15; 197(12):4529-4534. Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ. PMID: 27837104.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity. 2016 09 20; 45(3):701-703. Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. PMID: 27653602.
      View in: PubMed   Mentions: 29     Fields:    
    8. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity. 2016 08 16; 45(2):374-88. Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. PMID: 27496732.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    9. B cell IFN-? receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 2016 05 02; 213(5):733-50. Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ. PMID: 27069113.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    10. Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells. J Immunol. 2016 05 01; 196(9):3525-31. Jacobs HM, Thouvenel CD, Leach S, Arkatkar T, Metzler G, Scharping NE, Kolhatkar NS, Rawlings DJ, Jackson SW. PMID: 27022196.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    11. B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome. Eur J Immunol. 2015 Oct; 45(10):2773-9. Kolhatkar NS, Scharping NE, Sullivan JM, Jacobs HM, Schwartz MA, Khim S, Notarangelo LD, Thrasher AJ, Rawlings DJ, Jackson SW. PMID: 26256668.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. J Immunol. 2014 May 15; 192(10):4525-32. Jackson SW, Scharping NE, Kolhatkar NS, Khim S, Schwartz MA, Li QZ, Hudkins KL, Alpers CE, Liggitt D, Rawlings DJ. PMID: 24711620.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    13. Roles of inflammatory caspases during processing of zebrafish interleukin-1ß in Francisella noatunensis infection. Infect Immun. 2012 Aug; 80(8):2878-85. Vojtech LN, Scharping N, Woodson JC, Hansen JD. PMID: 22689811.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells