Nicole Scharping

Title(s)Postdoctoral Scholar, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Tumor-infiltrating T cell metabolic dysfunction and genetic reprogramming for effective immunotherapy
    NIH K00CA222711Mar 1, 2020 - Feb 29, 2024
    Role: Principal Investigator
    Tumor-infiltrating T cell metabolic dysfunction and genetic reprogramming for effective immunotherapy
    NIH F99CA222711Sep 14, 2017 - Aug 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted. bioRxiv. 2024 Mar 25. Reina-Campos M, Monell A, Ferry A, Luna V, Cheung KP, Galletti G, Scharping NE, Takehara KK, Quon S, Boland B, Lin YH, Wong WH, Indralingam CS, Yeo GW, Chang JT, Heeg M, Goldrath AW. PMID: 38585842; PMCID: PMC10996520.
      View in: PubMed   Mentions:
    2. Lessons for the Next Generation of Scientists from the Second Annual Arthur and Sandra Irving Cancer Immunology Symposium. Cancer Immunol Res. 2023 12 01; 11(12):1571-1577. Alvarez-Breckenridge C, Anderson KG, Correia AL, Demehri S, Dinh HQ, Dixon KO, Dunn GP, Evgin L, Goc J, Good Z, Hacohen N, Han P, Hanc P, Hickey J, Kersten K, Liu BC, Buque A, Miao Y', Milner JJ, Pritykin Y, Pucci F, Scharping NE, Sudmeier L, Wang Y, Wieland A, Williams MM. PMID: 37906619; PMCID: PMC10696930.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity. Nat Immunol. 2023 02; 24(2):267-279. Vignali PDA, DePeaux K, Watson MJ, Ye C, Ford BR, Lontos K, McGaa NK, Scharping NE, Menk AV, Robson SC, Poholek AC, Rivadeneira DB, Delgoffe GM. PMID: 36543958; PMCID: PMC10402660.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    4. Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells. Sci Immunol. 2022 08 05; 7(74):eabj9123. Ford BR, Vignali PDA, Rittenhouse NL, Scharping NE, Peralta R, Lontos K, Frisch AT, Delgoffe GM, Poholek AC. PMID: 35930654; PMCID: PMC9851604.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    5. TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice. Eur J Immunol. 2021 09; 51(9):2225-2236. Jacobs HM, Arkatkar T, Du SW, Scharping NE, Woods J, Li QZ, Hudkins KL, Alpers CE, Rawlings DJ, Jackson SW. PMID: 34146342; PMCID: PMC8410679.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection. J Exp Med. 2021 08 02; 218(8). Milner JJ, Toma C, Quon S, Omilusik K, Scharping NE, Dey A, Reina-Campos M, Nguyen H, Getzler AJ, Diao H, Yu B, Delpoux A, Yoshida TM, Li D, Qi J, Vincek A, Hedrick SM, Egawa T, Zhou MM, Crotty S, Ozato K, Pipkin ME, Goldrath AW. PMID: 34037670; PMCID: PMC8160575.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. CD8+ T cell metabolism in infection and cancer. Nat Rev Immunol. 2021 11; 21(11):718-738. Reina-Campos M, Scharping NE, Goldrath AW. PMID: 33981085; PMCID: PMC8806153.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    8. Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells. J Clin Invest. 2021 04 01; 131(7). Liikanen I, Lauhan C, Quon S, Omilusik K, Phan AT, Bartrolí LB, Ferry A, Goulding J, Chen J, Scott-Browne JP, Yustein JT, Scharping NE, Witherden DA, Goldrath AW. PMID: 33792560; PMCID: PMC8011896.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    9. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nat Immunol. 2021 02; 22(2):205-215. Scharping NE, Rivadeneira DB, Menk AV, Vignali PDA, Ford BR, Rittenhouse NL, Peralta R, Wang Y, Wang Y, DePeaux K, Poholek AC, Delgoffe GM. PMID: 33398183; PMCID: PMC7971090.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansAnimalsCells
    10. IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell. Cancer Immunol Res. 2019 08; 7(8):1258-1266. Shao L, Hou W, Scharping NE, Vendetti FP, Srivastava R, Roy CN, Menk AV, Wang Y, Chauvin JM, Karukonda P, Thorne SH, Hornung V, Zarour HM, Bakkenist CJ, Delgoffe GM, Sarkar SN. PMID: 31239318; PMCID: PMC6677597.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    11. 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses. J Exp Med. 2018 04 02; 215(4):1091-1100. Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM. PMID: 29511066; PMCID: PMC5881463.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    12. Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions. Cell Rep. 2018 02 06; 22(6):1509-1521. Menk AV, Scharping NE, Moreci RS, Zeng X, Guy C, Salvatore S, Bae H, Xie J, Young HA, Wendell SG, Delgoffe GM. PMID: 29425506; PMCID: PMC5973810.
      View in: PubMed   Mentions: 198     Fields:    Translation:AnimalsCells
    13. Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia. Cancer Immunol Res. 2017 01; 5(1):9-16. Scharping NE, Menk AV, Whetstone RD, Zeng X, Delgoffe GM. PMID: 27941003; PMCID: PMC5340074.
      View in: PubMed   Mentions: 238     Fields:    Translation:AnimalsCells
    14. Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity. Vaccines (Basel). 2016 Dec 06; 4(4). Scharping NE, Delgoffe GM. PMID: 27929420; PMCID: PMC5192366.
      View in: PubMed   Mentions: 48  
    15. Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation. J Immunol. 2016 12 15; 197(12):4529-4534. Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ. PMID: 27837104; PMCID: PMC5147509.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity. 2016 09 20; 45(3):701-703. Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. PMID: 27653602.
      View in: PubMed   Mentions: 91     Fields:    
    17. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity. 2016 08 16; 45(2):374-88. Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. PMID: 27496732; PMCID: PMC5207350.
      View in: PubMed   Mentions: 318     Fields:    Translation:HumansAnimalsCells
    18. B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 2016 05 02; 213(5):733-50. Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ. PMID: 27069113; PMCID: PMC4854732.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    19. Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells. J Immunol. 2016 05 01; 196(9):3525-31. Jacobs HM, Thouvenel CD, Leach S, Arkatkar T, Metzler G, Scharping NE, Kolhatkar NS, Rawlings DJ, Jackson SW. PMID: 27022196; PMCID: PMC4868625.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    20. B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome. Eur J Immunol. 2015 Oct; 45(10):2773-9. Kolhatkar NS, Scharping NE, Sullivan JM, Jacobs HM, Schwartz MA, Khim S, Notarangelo LD, Thrasher AJ, Rawlings DJ, Jackson SW. PMID: 26256668; PMCID: PMC4679197.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    21. Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. J Immunol. 2014 May 15; 192(10):4525-32. Jackson SW, Scharping NE, Kolhatkar NS, Khim S, Schwartz MA, Li QZ, Hudkins KL, Alpers CE, Liggitt D, Rawlings DJ. PMID: 24711620; PMCID: PMC4041708.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    22. Roles of inflammatory caspases during processing of zebrafish interleukin-1β in Francisella noatunensis infection. Infect Immun. 2012 Aug; 80(8):2878-85. Vojtech LN, Scharping N, Woodson JC, Hansen JD. PMID: 22689811; PMCID: PMC3434560.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    With one click, see people who:

    Mentor Faculty

    Run Clinical Trials

    See more options in the Advanced Search tab

    Nicole's Networks
    Concepts (121)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (10)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI).
    This site is running Profiles RNS version UCSF-v3.1.0-3-g1ef1264b on PROFILES-PWEB03. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California