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Eric Bennett

Title(s)Associate Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Defining the function and mechanism of regulatory ribosomal ubiquitylation
    NIH R01GM136994Jan 1, 2021 - Dec 31, 2024
    Role: Principal Investigator
    Leveraging orphan protein degradation pathways to target cells with unstable proteomes
    NIH R01GM127681Sep 17, 2018 - Aug 31, 2022
    Role: Principal Investigator
    Manipulating Protein Homeostasis through Specialized Quality Control Ribosomes
    NIH DP2GM119132Sep 30, 2015 - May 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ribosome quality control activity potentiates vaccinia virus protein synthesis during infection. J Cell Sci. 2021 Apr 15; 134(8). Sundaramoorthy E, Ryan AP, Fulzele A, Leonard M, Daugherty MD, Bennett EJ. PMID: 33912921.
      View in: PubMed   Mentions:    Fields:    
    2. Enzymatic RNA Biotinylation for Affinity Purification and Identification of RNA-Protein Interactions. ACS Chem Biol. 2020 08 21; 15(8):2247-2258. Busby KN, Fulzele A, Zhang D, Bennett EJ, Devaraj NK. PMID: 32706237.
      View in: PubMed   Mentions:    Fields:    
    3. EDF1 coordinates cellular responses to ribosome collisions. Elife. 2020 08 03; 9. Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper JW, Bennett EJ, Beckmann R, Green R. PMID: 32744497.
      View in: PubMed   Mentions: 2     Fields:    
    4. PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2. J Cell Biol. 2020 Jun 01; 219(6). Xu X, Hou B, Fulzele A, Masubuchi T, Zhao Y, Wu Z, Hu Y, Jiang Y, Ma Y, Wang H, Bennett EJ, Fu G, Hui E. PMID: 32437509.
      View in: PubMed   Mentions: 1     Fields:    
    5. A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7950-7960. Panek J, Gang SS, Reddy KC, Luallen RJ, Fulzele A, Bennett EJ, Troemel ER. PMID: 32193347.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized. Elife. 2020 Feb 03; 9. Garshott DM, Sundaramoorthy E, Leonard M, Bennett EJ. PMID: 32011234.
      View in: PubMed   Mentions: 5     Fields:    
    7. Bombardier Enables Delivery of Short-Form Bomanins in the Drosophila Toll Response. Front Immunol. 2019; 10:3040. Lin SJH, Fulzele A, Cohen LB, Bennett EJ, Wasserman SA. PMID: 31998316.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics. Cell Rep. 2019 04 30; 27(5):1356-1363.e3. Markmiller S, Fulzele A, Higgins R, Leonard M, Yeo GW, Bennett EJ. PMID: 31042464.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins. Plant Physiol. 2018 07; 177(3):1170-1186. Lee CM, Feke A, Li MW, Adamchek C, Webb K, Pruneda-Paz J, Bennett EJ, Kay SA, Gendron JM. PMID: 29794020.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. USP11 Enhances TGFß-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis. Mol Cancer Res. 2018 07; 16(7):1172-1184. Garcia DA, Baek C, Estrada MV, Tysl T, Bennett EJ, Yang J, Chang JT. PMID: 29724812.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. Mol Biol Cell. 2018 05 15; 29(10):1258-1269. Zuzow N, Ghosh A, Leonard M, Liao J, Yang B, Bennett EJ. PMID: 29540532.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 01 25; 172(3):590-604.e13. Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. PMID: 29373831.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    13. Ubiquitin diGLY Proteomics as an Approach to Identify and Quantify the Ubiquitin-Modified Proteome. Methods Mol Biol. 2018; 1844:363-384. Fulzele A, Bennett EJ. PMID: 30242721.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun. 2017 10 27; 8(1):1171. Lumpkin RJ, Gu H, Zhu Y, Leonard M, Ahmad AS, Clauser KR, Meyer JG, Bennett EJ, Komives EA. PMID: 29079793.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    15. In vivo mapping of tissue- and subcellular-specific proteomes in Caenorhabditis elegans. Sci Adv. 2017 May; 3(5):e1602426. Reinke AW, Mak R, Troemel ER, Bennett EJ. PMID: 28508060.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Mol Cell. 2017 Feb 16; 65(4):751-760.e4. Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ. PMID: 28132843.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    17. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar; 49(3):457-464. Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çaglayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG. PMID: 28092684.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    18. A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates. J Biol Chem. 2017 02 24; 292(8):3112-3128. Neal S, Mak R, Bennett EJ, Hampton R. PMID: 28077573.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins. Nat Commun. 2017 01 09; 8:14023. Reinke AW, Balla KM, Bennett EJ, Troemel ER. PMID: 28067236.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    20. Proteome complexity and the forces that drive proteome imbalance. Nature. 2016 09 15; 537(7620):328-38. Harper JW, Bennett EJ. PMID: 27629639.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    21. The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation. Mol Cell Biol. 2016 09 01; 36(17):2226-35. Arribas-Layton M, Dennis J, Bennett EJ, Damgaard CK, Lykke-Andersen J. PMID: 27247266.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    22. Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction. Mol Cell Proteomics. 2016 08; 15(8):2576-93. Gendron JM, Webb K, Yang B, Rising L, Zuzow N, Bennett EJ. PMID: 27185884.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    23. Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements. RNA. 2016 Mar; 22(3):373-82. Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J. PMID: 26763119.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    24. The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Mol Cell. 2015 Jul 02; 59(1):35-49. Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ. PMID: 26051182.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    25. Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity. Mol Cell Biol. 2015 Jun; 35(12):2144-53. Erickson SL, Corpuz EO, Maloy JP, Fillman C, Webb K, Bennett EJ, Lykke-Andersen J. PMID: 25870104.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    26. The SCAR/WAVE complex polarizes PAN receptors and promotes division asymmetry in maize. Nat Plants. 2015 Jan 26; 1:14024. Facette MR, Park Y, Sutimantanapi D, Luo A, Cartwright HN, Yang B, Bennett EJ, Sylvester AW, Smith LG. PMID: 27246760.
      View in: PubMed   Mentions: 20     Fields:    
    27. Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):15981-6. Lyumkis D, Oliveira dos Passos D, Tahara EB, Webb K, Bennett EJ, Vinterbo S, Potter CS, Carragher B, Joazeiro CA. PMID: 25349383.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    28. TIF1? protein regulates epithelial-mesenchymal transition by operating as a small ubiquitin-like modifier (SUMO) E3 ligase for the transcriptional regulator SnoN1. J Biol Chem. 2014 Sep 05; 289(36):25067-78. Ikeuchi Y, Dadakhujaev S, Chandhoke AS, Huynh MA, Oldenborg A, Ikeuchi M, Deng L, Bennett EJ, Harper JW, Bonni A, Bonni S. PMID: 25059663.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    29. Protecting the proteome: Eukaryotic cotranslational quality control pathways. J Cell Biol. 2014 Feb 17; 204(4):467-76. Lykke-Andersen J, Bennett EJ. PMID: 24535822.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    30. A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain. J Neurosci. 2013 Nov 13; 33(46):18015-21. Mejia LA, Litterman N, Ikeuchi Y, de la Torre-Ubieta L, Bennett EJ, Zhang C, Harper JW, Bonni A. PMID: 24227713.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails. J Biol Chem. 2013 Nov 29; 288(48):34882-96. Ziemba A, Hill S, Sandoval D, Webb K, Bennett EJ, Kleiger G. PMID: 24129577.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    32. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. Mol Cell. 2013 Oct 10; 52(1):9-24. Tan MK, Lim HJ, Bennett EJ, Shi Y, Harper JW. PMID: 24035498.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    33. Eavesdropping on PTM cross-talk through serial enrichment. Nat Methods. 2013 Jul; 10(7):620-1. Webb K, Bennett EJ. PMID: 23807195.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Using the ubiquitin-modified proteome to monitor protein homeostasis function. Mol Cell Proteomics. 2013 Dec; 12(12):3521-31. Carrano AC, Bennett EJ. PMID: 23704779.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    35. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol Cell Biol. 2013 Apr; 33(8):1487-502. Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA. PMID: 23382074.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    36. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. Structure. 2013 Jan 08; 21(1):42-53. Monda JK, Scott DC, Miller DJ, Lydeard J, King D, Harper JW, Bennett EJ, Schulman BA. PMID: 23201271.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    37. Proteomics propels protein degradation studies in San Diego. Mol Cell Proteomics. 2012 Dec; 11(12):1523-8. Bennett EJ, Mayor T. PMID: 22798279.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    38. Defining human ERAD networks through an integrative mapping strategy. Nat Cell Biol. 2011 Nov 27; 14(1):93-105. Christianson JC, Olzmann JA, Shaler TA, Sowa ME, Bennett EJ, Richter CM, Tyler RE, Greenblatt EJ, Harper JW, Kopito RR. PMID: 22119785.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    39. N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science. 2011 Nov 04; 334(6056):674-8. Scott DC, Monda JK, Bennett EJ, Harper JW, Schulman BA. PMID: 21940857.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    40. Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21; 44(2):325-40. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. PMID: 21906983.
      View in: PubMed   Mentions: 605     Fields:    Translation:HumansCells
    41. Simply quantifying ubiquitin complexity. Nat Methods. 2011 Jul 28; 8(8):630-1. Bennett EJ, Harper JW. PMID: 21799497.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    42. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10; 143(6):951-65. Bennett EJ, Rush J, Gygi SP, Harper JW. PMID: 21145461.
      View in: PubMed   Mentions: 149     Fields:    Translation:Cells
    43. Ubiquitin gets CARDed. Cell. 2010 Apr 16; 141(2):220-2. Bennett EJ, Harper JW. PMID: 20403317.
      View in: PubMed   Mentions: 2     Fields:    
    44. Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23; 138(2):389-403. Sowa ME, Bennett EJ, Gygi SP, Harper JW. PMID: 19615732.
      View in: PubMed   Mentions: 662     Fields:    Translation:HumansCells
    45. Global changes to the ubiquitin system in Huntington's disease. Nature. 2007 Aug 09; 448(7154):704-8. Bennett EJ, Shaler TA, Woodman B, Ryu KY, Zaitseva TS, Becker CH, Bates GP, Schulman H, Kopito RR. PMID: 17687326.
      View in: PubMed   Mentions: 207     Fields:    Translation:HumansAnimalsCells
    46. Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol Cell. 2005 Feb 04; 17(3):351-65. Bennett EJ, Bence NF, Jayakumar R, Kopito RR. PMID: 15694337.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansCells
    47. Application and analysis of the GFPu family of ubiquitin-proteasome system reporters. Methods Enzymol. 2005; 399:481-90. Bence NF, Bennett EJ, Kopito RR. PMID: 16338377.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    48. Catalytic implications from the Drosophila protein L-isoaspartyl methyltransferase structure and site-directed mutagenesis. Biochemistry. 2003 Nov 11; 42(44):12844-53. Bennett EJ, Bjerregaard J, Knapp JE, Chavous DA, Friedman AM, Royer WE, O'Connor CM. PMID: 14596598.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
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