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Eric Bennett

TitleAssociate Researcher
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0380
La Jolla CA 92093
Phone858-822-7900
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    Collapse Research 
    Collapse Research Activities and Funding
    Manipulating Protein Homeostasis through Specialized Quality Control Ribosomes
    NIH/NIGMS DP2GM119132Sep 30, 2015 - May 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee CM, Feke A, Li MW, Adamchek C, Webb K, Pruneda-Paz J, Bennett EJ, Kay SA, Gendron JM. Decoys untangle complicated redundancy and reveal targets of circadian clock F-box proteins. Plant Physiol. 2018 May 23. PMID: 29794020.
      View in: PubMed
    2. Garcia DA, Baek C, Estrada MV, Tysl T, Bennett EJ, Yang J, Chang JT. USP11 Enhances TGFß-induced Epithelial-mesenchymal Plasticity and Human Breast Cancer Metastasis. Mol Cancer Res. 2018 May 03. PMID: 29724812.
      View in: PubMed
    3. Zuzow N, Ghosh A, Leonard M, Liao J, Yang B, Bennett EJ. Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. Mol Biol Cell. 2018 May 15; 29(10):1258-1269. PMID: 29540532.
      View in: PubMed
    4. Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25; 172(3):590-604.e13. PMID: 29373831.
      View in: PubMed
    5. Lumpkin RJ, Gu H, Zhu Y, Leonard M, Ahmad AS, Clauser KR, Meyer JG, Bennett EJ, Komives EA. Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun. 2017 Oct 27; 8(1):1171. PMID: 29079793.
      View in: PubMed
    6. Reinke AW, Mak R, Troemel ER, Bennett EJ. In vivo mapping of tissue- and subcellular-specific proteomes in Caenorhabditis elegans. Sci Adv. 2017 May; 3(5):e1602426. PMID: 28508060.
      View in: PubMed
    7. Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Mol Cell. 2017 Feb 16; 65(4):751-760.e4. PMID: 28132843.
      View in: PubMed
    8. Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çaglayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar; 49(3):457-464. PMID: 28092684.
      View in: PubMed
    9. Neal S, Mak R, Bennett EJ, Hampton R. A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates. J Biol Chem. 2017 02 24; 292(8):3112-3128. PMID: 28077573.
      View in: PubMed
    10. Reinke AW, Balla KM, Bennett EJ, Troemel ER. Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins. Nat Commun. 2017 Jan 09; 8:14023. PMID: 28067236.
      View in: PubMed
    11. Harper JW, Bennett EJ. Proteome complexity and the forces that drive proteome imbalance. Nature. 2016 09 15; 537(7620):328-38. PMID: 27629639.
      View in: PubMed
    12. Arribas-Layton M, Dennis J, Bennett EJ, Damgaard CK, Lykke-Andersen J. The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation. Mol Cell Biol. 2016 09 01; 36(17):2226-35. PMID: 27247266.
      View in: PubMed
    13. Gendron JM, Webb K, Yang B, Rising L, Zuzow N, Bennett EJ. Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction. Mol Cell Proteomics. 2016 08; 15(8):2576-93. PMID: 27185884; PMCID: PMC4974337 [Available on 08/01/17].
    14. Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J. Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements. RNA. 2016 Mar; 22(3):373-82. PMID: 26763119; PMCID: PMC4748815 [Available on 03/01/17].
    15. Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ. The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Mol Cell. 2015 Jul 02; 59(1):35-49. PMID: 26051182; PMCID: PMC4491043.
    16. Erickson SL, Corpuz EO, Maloy JP, Fillman C, Webb K, Bennett EJ, Lykke-Andersen J. Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity. Mol Cell Biol. 2015 Jun; 35(12):2144-53. PMID: 25870104; PMCID: PMC4438239.
    17. Facette MR, Park Y, Sutimantanapi D, Luo A, Cartwright HN, Yang B, Bennett EJ, Sylvester AW, Smith LG. The SCAR/WAVE complex polarizes PAN receptors and promotes division asymmetry in maize. Nat Plants. 2015 Jan 26; 1:14024. PMID: 27246760.
      View in: PubMed
    18. Lyumkis D, Oliveira dos Passos D, Tahara EB, Webb K, Bennett EJ, Vinterbo S, Potter CS, Carragher B, Joazeiro CA. Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):15981-6. PMID: 25349383; PMCID: PMC4234556.
    19. Ikeuchi Y, Dadakhujaev S, Chandhoke AS, Huynh MA, Oldenborg A, Ikeuchi M, Deng L, Bennett EJ, Harper JW, Bonni A, Bonni S. TIF1? protein regulates epithelial-mesenchymal transition by operating as a small ubiquitin-like modifier (SUMO) E3 ligase for the transcriptional regulator SnoN1. J Biol Chem. 2014 Sep 05; 289(36):25067-78. PMID: 25059663; PMCID: PMC4155673.
    20. Lykke-Andersen J, Bennett EJ. Protecting the proteome: Eukaryotic cotranslational quality control pathways. J Cell Biol. 2014 Feb 17; 204(4):467-76. PMID: 24535822; PMCID: PMC3926952.
    21. Mejia LA, Litterman N, Ikeuchi Y, de la Torre-Ubieta L, Bennett EJ, Zhang C, Harper JW, Bonni A. A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain. J Neurosci. 2013 Nov 13; 33(46):18015-21. PMID: 24227713; PMCID: PMC3828457.
    22. Ziemba A, Hill S, Sandoval D, Webb K, Bennett EJ, Kleiger G. Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails. J Biol Chem. 2013 Nov 29; 288(48):34882-96. PMID: 24129577; PMCID: PMC3843100.
    23. Tan MK, Lim HJ, Bennett EJ, Shi Y, Harper JW. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. Mol Cell. 2013 Oct 10; 52(1):9-24. PMID: 24035498; PMCID: PMC3981468.
    24. Webb K, Bennett EJ. Eavesdropping on PTM cross-talk through serial enrichment. Nat Methods. 2013 Jul; 10(7):620-1. PMID: 23807195.
      View in: PubMed
    25. Zhang C, Mejia LA, Huang J, Valnegri P, Bennett EJ, Anckar J, Jahani-Asl A, Gallardo G, Ikeuchi Y, Yamada T, Rudnicki M, Harper JW, Bonni A. The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain. Neuron. 2013 Jun 19; 78(6):986-93. PMID: 23791194; PMCID: PMC3694281.
    26. Carrano AC, Bennett EJ. Using the ubiquitin-modified proteome to monitor protein homeostasis function. Mol Cell Proteomics. 2013 Dec; 12(12):3521-31. PMID: 23704779; PMCID: PMC3861705.
    27. Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol Cell Biol. 2013 Apr; 33(8):1487-502. PMID: 23382074; PMCID: PMC3624249.
    28. Monda JK, Scott DC, Miller DJ, Lydeard J, King D, Harper JW, Bennett EJ, Schulman BA. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. Structure. 2013 Jan 08; 21(1):42-53. PMID: 23201271; PMCID: PMC3786212.
    29. Bennett EJ, Mayor T. Proteomics propels protein degradation studies in San Diego. Mol Cell Proteomics. 2012 Dec; 11(12):1523-8. PMID: 22798279; PMCID: PMC3518107.
    30. Christianson JC, Olzmann JA, Shaler TA, Sowa ME, Bennett EJ, Richter CM, Tyler RE, Greenblatt EJ, Harper JW, Kopito RR. Defining human ERAD networks through an integrative mapping strategy. Nat Cell Biol. 2011 Nov 27; 14(1):93-105. PMID: 22119785; PMCID: PMC3250479.
    31. Scott DC, Monda JK, Bennett EJ, Harper JW, Schulman BA. N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science. 2011 Nov 04; 334(6056):674-8. PMID: 21940857; PMCID: PMC3214010.
    32. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21; 44(2):325-40. PMID: 21906983; PMCID: PMC3200427.
    33. Bennett EJ, Harper JW. Simply quantifying ubiquitin complexity. Nat Methods. 2011 Jul 28; 8(8):630-1. PMID: 21799497.
      View in: PubMed
    34. Bennett EJ, Rush J, Gygi SP, Harper JW. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10; 143(6):951-65. PMID: 21145461; PMCID: PMC3008586.
    35. Bennett EJ, Harper JW. Ubiquitin gets CARDed. Cell. 2010 Apr 16; 141(2):220-2. PMID: 20403317.
      View in: PubMed
    36. Sowa ME, Bennett EJ, Gygi SP, Harper JW. Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23; 138(2):389-403. PMID: 19615732; PMCID: PMC2716422.
    37. Bennett EJ, Harper JW. DNA damage: ubiquitin marks the spot. Nat Struct Mol Biol. 2008 Jan; 15(1):20-2. PMID: 18176551.
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    38. Bennett EJ, Shaler TA, Woodman B, Ryu KY, Zaitseva TS, Becker CH, Bates GP, Schulman H, Kopito RR. Global changes to the ubiquitin system in Huntington's disease. Nature. 2007 Aug 09; 448(7154):704-8. PMID: 17687326.
      View in: PubMed
    39. Bennett EJ, Shaler T, Gonzalez-Zulueta M, Schulman HF, Iwata A, Riley BE, Johnston JA, Bucci M, Nukina N, Ellerby L, Kopito RR. [Cellular mechanisms of protein quality control]. Rinsho Shinkeigaku. 2006 Nov; 46(11):805. PMID: 17432184.
      View in: PubMed
    40. Bennett EJ, Bence NF, Jayakumar R, Kopito RR. Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol Cell. 2005 Feb 04; 17(3):351-65. PMID: 15694337.
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    41. Bence NF, Bennett EJ, Kopito RR. Application and analysis of the GFPu family of ubiquitin-proteasome system reporters. Methods Enzymol. 2005; 399:481-90. PMID: 16338377.
      View in: PubMed
    42. Bennett EJ, Bjerregaard J, Knapp JE, Chavous DA, Friedman AM, Royer WE, O'Connor CM. Catalytic implications from the Drosophila protein L-isoaspartyl methyltransferase structure and site-directed mutagenesis. Biochemistry. 2003 Nov 11; 42(44):12844-53. PMID: 14596598.
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