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Christopher Hupfeld

TitleAssociate Clinical Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #9111
La Jolla CA 92093
Phone858-552-8585
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    Collapse Research 
    Collapse Research Activities and Funding
    Using BRET to measure insulin resistance and receptor cross-talk
    NIH/NIDDK R03DK075389Jul 1, 2006 - Jun 30, 2008
    Role: Principal Investigator
    Insulin, beta-Arrestin 1, and GPCR Signaling
    NIH/NIDDK K08DK065127Sep 30, 2003 - Jun 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kendall MR, Hupfeld C. FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice. Diabetes Obes Metab. 2008 Sep; 10(9):802-5. PMID: 18494802.
      View in: PubMed
    2. Hupfeld C, Olefsky JM. Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol. 2007; 69:561-77. PMID: 17002595.
      View in: PubMed
    3. Zhang J, Hupfeld C, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 2005 Sep 22; 437(7058):569-73. PMID: 16177793.
      View in: PubMed
    4. Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld C, Olefsky JM. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Nov; 19(11):2760-8. PMID: 15994203.
      View in: PubMed
    5. Hupfeld C, Resnik JL, Ugi S, Olefsky JM. Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors. J Biol Chem. 2005 Jan 14; 280(2):1016-23. PMID: 15520010.
      View in: PubMed
    6. Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld C, Olefsky JM. beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol. 2004 Oct; 24(20):8929-37. PMID: 15456867; PMCID: PMC517874.
    7. Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld C, Olefsky JM. GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 2004 Jul 21; 23(14):2821-9. PMID: 15241473; PMCID: PMC514955.
    8. Hupfeld C, Wong GA. Current recommendations for prevention of cardiovascular disease in patients with diabetes mellitus. Part II of II. Prev Cardiol. 2003; 6(1):34-7. PMID: 12624560.
      View in: PubMed
    9. Hupfeld C, Dalle S, Olefsky JM. Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):161-6. PMID: 12509508; PMCID: PMC140914.
    10. Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld C, Olefsky JM. Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol. 2002 Sep; 22(17):6272-85. PMID: 12167719; PMCID: PMC134007.
    11. Hupfeld C, Wong GA. Molecular mechanisms of diabetic cardiovascular disease. Prev Cardiol. 2002; 5(4):183-7. PMID: 12417827.
      View in: PubMed
    12. Hupfeld C, Weiss RH. TZDs inhibit vascular smooth muscle cell growth independently of the cyclin kinase inhibitors p21 and p27. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E207-16. PMID: 11440895.
      View in: PubMed
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