Christopher Hupfeld

Title(s)	Clinical Professor, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Using BRET to measure insulin resistance and receptor cross-talk
NIH R03DK075389Jul 1, 2006 - Jun 30, 2008
Role: Principal Investigator

Insulin, beta-Arrestin 1, and GPCR Signaling
NIH K08DK065127Sep 30, 2003 - Jun 30, 2008
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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SGLT2 Inhibitor-Induced Low-Grade Ketonemia Ameliorates Retinal Hypoxia in Diabetic Retinopathy-A Novel Hypothesis. J Clin Endocrinol Metab. 2021 04 23; 106(5):1235-1244. Mudaliar S, Hupfeld C, Chao DL. PMID: 33512450.

View in: PubMed Mentions: 12 Fields:
End Endocrinology Met Metabolism
Translation:Humans Animals
Sodium-Glucose Cotransporter Type 2 (SGLT-2) Inhibitors and Ketogenesis: the Good and the Bad. Curr Diab Rep. 2020 11 23; 20(12):74. Ekanayake P, Hupfeld C, Mudaliar S. PMID: 33230620.

View in: PubMed Mentions: 13 Fields:
End Endocrinology
Translation:Humans
Navigating the "MACE" in Cardiovascular Outcomes Trials and decoding the relevance of Atherosclerotic Cardiovascular Disease benefits versus Heart Failure benefits. Diabetes Obes Metab. 2019 08; 21(8):1780-1789. Hupfeld C, Mudaliar S. PMID: 30957945.

View in: PubMed Mentions: 22 Fields:
End Endocrinology Met Metabolism
Translation:Humans
VISUAL VIGNETTE. Endocr Pract. 2019 Aug; 25(8):861. Kimura BH, Farjoudi F, Hupfeld CJ. PMID: 30657363.

View in: PubMed Mentions: Fields:
End Endocrinology
FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice. Diabetes Obes Metab. 2008 Sep; 10(9):802-5. Kendall MR, Hupfeld CJ. PMID: 18494802.

View in: PubMed Mentions: 23 Fields:
End Endocrinology Met Metabolism
Translation:Animals
Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol. 2007; 69:561-77. Hupfeld CJ, Olefsky JM. PMID: 17002595.

View in: PubMed Mentions: 32 Fields:
Phy Physiology
Translation:Humans Animals Cells
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 2005 Sep 22; 437(7058):569-73. Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. PMID: 16177793.

View in: PubMed Mentions: 146 Fields:
Sci Science
Translation:Humans Animals Cells
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Nov; 19(11):2760-8. Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky JM. PMID: 15994203.

View in: PubMed Mentions: 46 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Investigations in pet birds (Agapornis spp.) fed different vitamin K contents in the diet. J Anim Physiol Anim Nutr (Berl). 2005 Apr-Jun; 89(3-6):222-8. Wolf P, Hupfeld C, Dorrestein G, Kamphues J. PMID: 15787999.

View in: PubMed Mentions: Fields:
Nut Nutritional Sciences Phy Physiology Vet Veterinary Medicine
Translation:Animals
Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors. J Biol Chem. 2005 Jan 14; 280(2):1016-23. Hupfeld CJ, Resnik JL, Ugi S, Olefsky JM. PMID: 15520010.

View in: PubMed Mentions: 19 Fields:
Bio Biochemistry
Translation:Cells
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol. 2004 Oct; 24(20):8929-37. Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld CJ, Olefsky JM. PMID: 15456867; PMCID: PMC517874.

View in: PubMed Mentions: 27 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 2004 Jul 21; 23(14):2821-9. Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld CJ, Olefsky JM. PMID: 15241473; PMCID: PMC514955.

View in: PubMed Mentions: 39 Fields:
Bio Biotechnology Mol Molecular Biology
Translation:Animals Cells
Current recommendations for prevention of cardiovascular disease in patients with diabetes mellitus. Part II of II. Prev Cardiol. 2003; 6(1):34-7. Hupfeld CJ, Wong GA. PMID: 12624560.

View in: PubMed Mentions: Fields:
Car Cardiology
Translation:Humans
Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):161-6. Hupfeld CJ, Dalle S, Olefsky JM. PMID: 12509508; PMCID: PMC140914.

View in: PubMed Mentions: 13 Fields:
Sci Science
Translation:Animals Cells
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol. 2002 Sep; 22(17):6272-85. Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky JM. PMID: 12167719; PMCID: PMC134007.

View in: PubMed Mentions: 24 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Molecular mechanisms of diabetic cardiovascular disease. Prev Cardiol. 2002; 5(4):183-7. Hupfeld CJ, Wong GA. PMID: 12417827.

View in: PubMed Mentions: Fields:
Car Cardiology
Translation:Humans PHPublic Health
TZDs inhibit vascular smooth muscle cell growth independently of the cyclin kinase inhibitors p21 and p27. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E207-16. Hupfeld CJ, Weiss RH. PMID: 11440895.

View in: PubMed Mentions: 4 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells