Christopher Hupfeld

Title(s)Clinical Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Using BRET to measure insulin resistance and receptor cross-talk
    NIH R03DK075389Jul 1, 2006 - Jun 30, 2008
    Role: Principal Investigator
    Insulin, beta-Arrestin 1, and GPCR Signaling
    NIH K08DK065127Sep 30, 2003 - Jun 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SGLT2 Inhibitor-Induced Low-Grade Ketonemia Ameliorates Retinal Hypoxia in Diabetic Retinopathy-A Novel Hypothesis. J Clin Endocrinol Metab. 2021 04 23; 106(5):1235-1244. Mudaliar S, Hupfeld C, Chao DL. PMID: 33512450.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    2. Sodium-Glucose Cotransporter Type 2 (SGLT-2) Inhibitors and Ketogenesis: the Good and the Bad. Curr Diab Rep. 2020 11 23; 20(12):74. Ekanayake P, Hupfeld C, Mudaliar S. PMID: 33230620.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    3. Navigating the "MACE" in Cardiovascular Outcomes Trials and decoding the relevance of Atherosclerotic Cardiovascular Disease benefits versus Heart Failure benefits. Diabetes Obes Metab. 2019 08; 21(8):1780-1789. Hupfeld C, Mudaliar S. PMID: 30957945.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    4. VISUAL VIGNETTE. Endocr Pract. 2019 Aug; 25(8):861. Kimura BH, Farjoudi F, Hupfeld CJ. PMID: 30657363.
      View in: PubMed   Mentions:    Fields:    
    5. FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice. Diabetes Obes Metab. 2008 Sep; 10(9):802-5. Kendall MR, Hupfeld CJ. PMID: 18494802.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    6. Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol. 2007; 69:561-77. Hupfeld CJ, Olefsky JM. PMID: 17002595.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    7. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 2005 Sep 22; 437(7058):569-73. Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. PMID: 16177793.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    8. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Nov; 19(11):2760-8. Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky JM. PMID: 15994203.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    9. Investigations in pet birds (Agapornis spp.) fed different vitamin K contents in the diet. J Anim Physiol Anim Nutr (Berl). 2005 Apr-Jun; 89(3-6):222-8. Wolf P, Hupfeld C, Dorrestein G, Kamphues J. PMID: 15787999.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors. J Biol Chem. 2005 Jan 14; 280(2):1016-23. Hupfeld CJ, Resnik JL, Ugi S, Olefsky JM. PMID: 15520010.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    11. beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol. 2004 Oct; 24(20):8929-37. Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld CJ, Olefsky JM. PMID: 15456867; PMCID: PMC517874.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    12. GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 2004 Jul 21; 23(14):2821-9. Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld CJ, Olefsky JM. PMID: 15241473; PMCID: PMC514955.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    13. Current recommendations for prevention of cardiovascular disease in patients with diabetes mellitus. Part II of II. Prev Cardiol. 2003; 6(1):34-7. Hupfeld CJ, Wong GA. PMID: 12624560.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):161-6. Hupfeld CJ, Dalle S, Olefsky JM. PMID: 12509508; PMCID: PMC140914.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    15. Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol. 2002 Sep; 22(17):6272-85. Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky JM. PMID: 12167719; PMCID: PMC134007.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    16. Molecular mechanisms of diabetic cardiovascular disease. Prev Cardiol. 2002; 5(4):183-7. Hupfeld CJ, Wong GA. PMID: 12417827.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    17. TZDs inhibit vascular smooth muscle cell growth independently of the cyclin kinase inhibitors p21 and p27. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E207-16. Hupfeld CJ, Weiss RH. PMID: 11440895.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
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