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Francesca Telese

TitleAssistant Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0648
La Jolla CA 92093
Phone858-246-2607
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    Collapse Biography 
    Collapse Education and Training
    University of Naples Federico II, ItalyPh.D.2007Neuroscience

    Collapse Overview 
    Collapse Overview
    My lab studies how the environment influences brain function in health and disease. We approach this broad question by studying epigenetic modifications that store the molecular responses of a cell to its environment. Our major focus is understanding epigenetic mechanisms underlying cell-type specific gene expression. We use next-generation sequencing techniques in cellular systems or model organisms. The identification and manipulation of epigenetic processes in the brain may enhance our basic understanding of brain function and open the door to new treatments for brain diseases.


    Collapse Research 
    Collapse Research Activities and Funding
    Epigenomic approaches to study the gene networks underlying the cannabis effects on genetic vulnerability to psychosis
    NIH DP1DA042232Jun 1, 2016 - Apr 30, 2021
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Yang F, Ma Q, Liu Z, Li W, Tan Y, Jin C, Ma W, Hu Y, Shen J, Ohgi KA, Telese F, Liu W, Rosenfeld MG. Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERa-Regulated Transcriptional Program. Mol Cell. 2017 May 04; 66(3):321-331.e6. PMID: 28475868.
      View in: PubMed
    2. Ma Q, Telese F. Genome-wide epigenetic analysis of MEF2A and MEF2C transcription factors in mouse cortical neurons. Commun Integr Biol. 2015 Nov-Dec; 8(6):e1087624. PMID: 27066173; PMCID: PMC4802763.
    3. Wang J, Telese F, Tan Y, Li W, Jin C, He X, Basnet H, Ma Q, Merkurjev D, Zhu X, Liu Z, Zhang J, Ohgi K, Taylor H, White RR, Tazearslan C, Suh Y, Macfarlan TS, Pfaff SL, Rosenfeld MG. LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nat Neurosci. 2015 Sep; 18(9):1256-64. PMID: 26214369; PMCID: PMC4625987.
    4. Telese F, Ma Q, Perez PM, Notani D, Oh S, Li W, Comoletti D, Ohgi KA, Taylor H, Rosenfeld MG. LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation. Neuron. 2015 May 06; 86(3):696-710. PMID: 25892301; PMCID: PMC4486257.
    5. Telese F, Gamliel A, Skowronska-Krawczyk D, Garcia-Bassets I, Rosenfeld MG. "Seq-ing" insights into the epigenetics of neuronal gene regulation. Neuron. 2013 Feb 20; 77(4):606-23. PMID: 23439116; PMCID: PMC3736682.
    6. Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature. 2009 Apr 02; 458(7238):591-6. PMID: 19234442; PMCID: PMC2692521.
    7. Garcia-Bassets I, Kwon YS, Telese F, Prefontaine GG, Hutt KR, Cheng CS, Ju BG, Ohgi KA, Wang J, Escoubet-Lozach L, Rose DW, Glass CK, Fu XD, Rosenfeld MG. Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell. 2007 Feb 09; 128(3):505-518. PMID: 17289570; PMCID: PMC1994663.
    8. Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T. Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem. 2007 Jan 12; 282(2):831-5. PMID: 17121854.
      View in: PubMed
    9. Telese F, Bruni P, Donizetti A, Gianni D, D'Ambrosio C, Scaloni A, Zambrano N, Rosenfeld MG, Russo T. Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET. EMBO Rep. 2005 Jan; 6(1):77-82. PMID: 15592452; PMCID: PMC1299219.
    10. Zambrano N, Gianni D, Bruni P, Passaro F, Telese F, Russo T. Fe65 is not involved in the platelet-derived growth factor-induced processing of Alzheimer's amyloid precursor protein, which activates its caspase-directed cleavage. J Biol Chem. 2004 Apr 16; 279(16):16161-9. PMID: 14766758.
      View in: PubMed