Roi Isaac

Title(s)	Assistant Project Scientist, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 Apr 11. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38605183.

View in: PubMed Mentions:
Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins. Cell Genom. 2023 Jul 12; 3(7):100339. DeForest N, Kavitha B, Hu S, Isaac R, Krohn L, Wang M, Du X, De Arruda Saldanha C, Gylys J, Merli E, Abagyan R, Najmi L, Mohan V, Alnylam Human Genetics, AMP-T2D Consortium, Flannick J, Peloso GM, Gordts PLSM, Heinz S, Deaton AM, Khera AV, Olefsky J, Radha V, Majithia AR. PMID: 37492105; PMCID: PMC10363808.

View in: PubMed Mentions: 2
HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity. Diabetes. 2022 07 01; 71(7):1508-1524. Moon JS, Riopel M, Seo JB, Herrero-Aguayo V, Isaac R, Lee YS. PMID: 35472707; PMCID: PMC9233300.

View in: PubMed Mentions: 1 Fields:
End Endocrinology
Translation:Animals
Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 06; 24(6):954-967. Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. PMID: 35637408; PMCID: PMC9233030.

View in: PubMed Mentions: 22 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021 09 07; 33(9):1744-1762. Isaac R, Reis FCG, Ying W, Olefsky JM. PMID: 34496230; PMCID: PMC8428804.

View in: PubMed Mentions: 150 Fields:
Cel Cell Biology Met Metabolism
Translation:Humans Cells
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nat Metab. 2021 09; 3(9):1163-1174. Ji Y, Luo Z, Gao H, Dos Reis FCG, Bandyopadhyay G, Jin Z, Manda KA, Isaac R, Yang M, Fu W, Ying W, Olefsky JM. PMID: 34489604; PMCID: PMC8460610.

View in: PubMed Mentions: 29 Fields:
Met Metabolism
Translation:Animals Cells
TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. Cell Metab. 2020 01 07; 31(1):162-173.e5. El Ouarrat D, Isaac R, Lee YS, Oh DY, Wollam J, Lackey D, Riopel M, Bandyopadhyay G, Seo JB, Sampath-Kumar R, Olefsky JM. PMID: 31708444; PMCID: PMC7784082.

View in: PubMed Mentions: 34 Fields:
Cel Cell Biology Met Metabolism
Translation:Humans Animals Cells
Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice. Sci Rep. 2019 10 14; 9(1):14779. Lackey DE, Reis FCG, Isaac R, Zapata RC, El Ouarrat D, Lee YS, Bandyopadhyay G, Ofrecio JM, Oh DY, Osborn O. PMID: 31611602; PMCID: PMC6791934.

View in: PubMed Mentions: 7 Fields:
Sci Science
Translation:Animals Cells
Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metab. 2019 02 05; 29(2):457-474.e5. Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. PMID: 30595478; PMCID: PMC6701710.

View in: PubMed Mentions: 102 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals Cells