Sohum Mehta

TitleAssistant Project Scientist
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0702
La Jolla CA 92093
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    1. Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD. Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. Elife. 2017 Oct 02; 6. PMID: 28967377.
      View in: PubMed
    2. Mehta S, Zhang J. Illuminating the Cell's Biochemical Activity Architecture. Biochemistry. 2017 10 03; 56(39):5210-5213. PMID: 28718621.
      View in: PubMed
    3. Ni Q, Mehta S, Zhang J. Live-cell imaging of cell signaling using genetically encoded fluorescent reporters. FEBS J. 2018 Jan; 285(2):203-219. PMID: 28613457.
      View in: PubMed
    4. Gorshkov K, Mehta S, Ramamurthy S, Ronnett GV, Zhou FQ, Zhang J. AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat Chem Biol. 2017 04; 13(4):425-431. PMID: 28192412.
      View in: PubMed
    5. Ross B, Mehta S, Zhang J. Molecular tools for acute spatiotemporal manipulation of signal transduction. Curr Opin Chem Biol. 2016 Oct; 34:135-142. PMID: 27639090.
      View in: PubMed
    6. Tenner B, Mehta S, Zhang J. Optical sensors to gain mechanistic insights into signaling assemblies. Curr Opin Struct Biol. 2016 12; 41:203-210. PMID: 27611602.
      View in: PubMed
    7. Depry C, Mehta S, Li R, Zhang J. Visualization of Compartmentalized Kinase Activity Dynamics Using Adaptable BimKARs. Chem Biol. 2015 Nov 19; 22(11):1470-1479. PMID: 26548610; PMCID: PMC4870014 [Available on 11/19/16].
    8. Mehta S, Zhang J. Light moves mountains in the cell. Chem Biol. 2015 May 21; 22(5):569-70. PMID: 26000746.
      View in: PubMed
    9. Mehta S, Zhang J. Dynamic visualization of calcium-dependent signaling in cellular microdomains. Cell Calcium. 2015 Oct; 58(4):333-41. PMID: 25703691; PMCID: PMC4519432 [Available on 10/01/16].
    10. Clister T, Mehta S, Zhang J. Single-cell analysis of G-protein signal transduction. J Biol Chem. 2015 Mar 13; 290(11):6681-8. PMID: 25605723; PMCID: PMC4358091.
    11. Mehta S, Aye-Han NN, Ganesan A, Oldach L, Gorshkov K, Zhang J. Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin. Elife. 2014 Jul 23; 3:e03765. PMID: 25056880; PMCID: PMC4141273.
    12. Sample V, Mehta S, Zhang J. Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems. J Cell Sci. 2014 Mar 15; 127(Pt 6):1151-60. PMID: 24634506; PMCID: PMC3953811.
    13. Mehta S, Zhang J. Using a genetically encoded FRET-based reporter to visualize calcineurin phosphatase activity in living cells. Methods Mol Biol. 2014; 1071:139-49. PMID: 24052386; PMCID: PMC4112951.
    14. Mehta S, Zhang J. Using a kinase-inducible bimolecular switch to control enzyme activity in living cells. Curr Protoc Chem Biol. 2013; 5(3):227-37. PMID: 24391085; PMCID: PMC3989098.
    15. Depry C, Mehta S, Zhang J. Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors. Pflugers Arch. 2013 Mar; 465(3):373-81. PMID: 23138230; PMCID: PMC3584185.
    16. Sample V, Ni Q, Mehta S, Inoue T, Zhang J. Controlling enzymatic action in living cells with a kinase-inducible bimolecular switch. ACS Chem Biol. 2013 Jan 18; 8(1):116-21. PMID: 23072367; PMCID: PMC3549020.
    17. Mehta S, Zhang J. Reporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems. Annu Rev Biochem. 2011; 80:375-401. PMID: 21495849; PMCID: PMC4384825.
    18. Mehta S, Li H, Hogan PG, Cunningham KW. Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast. Mol Cell Biol. 2009 May; 29(10):2777-93. PMID: 19273587; PMCID: PMC2682025.
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