Pamela Mellon

Title(s)Professor, Reproductive Medicine
SchoolHealth Sciences
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    Other Positions
    Title(s)Professor of Neurosciences

    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, Berkeley, CaliforniaPhD06/1979Molecular Biology
    California Institute of Technology, Pasadena, CaliforniaPostdoctoral12/1980Biology
    Harvard University, Cambridge, MassachusettsPostdoctoral08/1984Biochemistry and Molecular Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Neuroendocrine Actions of Androgens in Female Reproduction
    NIH/NICHD R01HD082567Apr 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Endocrine and Growth Factor Regulation in the Pituitary
    NIH/NIDDK R01DK068121Mar 1, 2005 - Mar 31, 2005
    Role: Principal Investigator
    Diabetes Research Center (DRC)
    NIH/NIDDK P30DK063491Dec 1, 2002 - Jun 30, 2020
    Role: Co-Investigator
    NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NIH/NIDDK R13DK050196Jul 28, 1995 - Jul 27, 1996
    Role: Principal Investigator
    NIH/CSR U09RG000146Jul 1, 1994 - Sep 29, 2006
    Role: Principal Investigator
    Neurosecretory Gene Expression in the Hypothalamus
    NIH/NICHD R01HD072754Jan 1, 1992 - Jun 30, 2017
    Role: Principal Investigator
    NIH/NICHD R37HD020377Jan 1, 1992 - Jul 31, 2006
    Role: Principal Investigator
    Neurosecretory Gene Expression in the Hypothalamus
    NIH/NIDDK R01DK044838Jul 1, 1991 - Aug 31, 2012
    Role: Principal Investigator
    NIH/NICHD R01HD023818Feb 1, 1988 - Jul 31, 1993
    Role: Principal Investigator
    NIH/NIDDK R03DK039798Sep 1, 1987 - Aug 31, 1988
    Role: Principal Investigator
    Molecular Mechanisms of Gonadotrope Differentiation
    NIH/NICHD R01HD020377Jul 1, 1985 - Jun 30, 2012
    Role: Principal Investigator
    Training in Reproductive Sciences
    NIH/NICHD T32HD007203Jul 1, 1979 - Apr 30, 2023
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH/NICHD P50HD012303Dec 1, 1978 - Mar 31, 2021
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH/NICHD U54HD012303Dec 1, 1978 - Mar 31, 2014
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tonsfeldt KJ, Schoeller EL, Brusman LE, Cui LJ, Lee J, Mellon PL. The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc. 2019 Apr 01; 3(4):716-733. PMID: 30906911.
      View in: PubMed
    2. Hoffmann HM, Larder R, Lee J, Hu R, Trang C, Devries B, Clark D, Mellon PL. Differential CRE expression in Lhrh-Cre and Gnrh-Cre alleles and the impact on fertility in Otx2-flox mice. Neuroendocrinology. 2019 Feb 10. PMID: 30739114.
      View in: PubMed
    3. Hoffmann H, Pandolfi E, Larder R, Mellon P. Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2, Causes Subfertility in Mice Via Distinct Mechanisms. Neuroendocrinology. 2018 Sep 27. PMID: 30261489.
      View in: PubMed
    4. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. PMID: 30013121.
      View in: PubMed
    5. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. PMID: 29875409.
      View in: PubMed
    6. Ryan GE, Malik S, Mellon PL. Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. Endocrinology. 2018 04 01; 159(4):1734-1747. PMID: 29471436.
      View in: PubMed
    7. Pandolfi EC, Hoffmann HM, Schoeller EL, Gorman MR, Mellon PL. Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol. 2018 Nov; 55(11):8709-8727. PMID: 29589282.
      View in: PubMed
    8. Xie H, Hoffmann HM, Iyer AK, Brayman MJ, Ngo C, Sunshine MJ, Mellon PL. Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol. 2017 Oct 24; 15(1):86. PMID: 29065928.
      View in: PubMed
    9. Hoffmann HM, Gong P, Tamrazian A, Mellon PL. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol. 2018 Feb 05; 461:143-154. PMID: 28890143.
      View in: PubMed
    10. Schoeller EL, Clark DD, Dey S, Cao NV, Semaan SJ, Chao LW, Kauffman AS, Stowers L, Mellon PL. Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology. 2016 Dec; 157(12):4914-4929. PMID: 27704948.
      View in: PubMed
    11. Hoffmann HM, Mellon PL. A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. Neurosci Commun (Houst). 2016; 2. PMID: 28164172.
      View in: PubMed
    12. Huang PP, Brusman LE, Iyer AK, Webster NJ, Mellon PL. A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. PLoS One. 2016; 11(7):e0158597. PMID: 27389022; PMCID: PMC4936741.
    13. Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC, Mellon PL. Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci. 2016 Mar 23; 36(12):3506-18. PMID: 27013679; PMCID: PMC4804008.
    14. Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zheng L, Krawczyk M, Chen D, Shi C, Zin C, Zhu J, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong S, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K. P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Mol Cell. 2015 Sep 17; 59(6):931-40. PMID: 26365380.
      View in: PubMed
    15. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175; PMCID: PMC4710190.
    16. Stephens SB, Tolson KP, Rouse ML, Poling MC, Hashimoto-Partyka MK, Mellon PL, Kauffman AS. Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice. Endocrinology. 2015 Sep; 156(9):3091-7. PMID: 26076042; PMCID: PMC4541622.
    17. Xie H, Hoffmann HM, Meadows JD, Mayo SL, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon PL. Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. Mol Endocrinol. 2015 Jun; 29(6):842-55. PMID: 25915183; PMCID: PMC4447639.
    18. Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon PL, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV. KISS1R signals independently of Gaq/11 and triggers LH secretion via the ß-arrestin pathway in the male mouse. Endocrinology. 2014 Nov; 155(11):4433-46. PMID: 25147978; PMCID: PMC4197989.
    19. Roybal LL, Hambarchyan A, Meadows JD, Barakat NH, Pepa PA, Breen KM, Mellon PL, Coss D. Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHß. Mol Endocrinol. 2014 Oct; 28(10):1640-55. PMID: 25105693; PMCID: PMC4179627.
    20. Hoffmann HM, Tamrazian A, Xie H, Pérez-Millán MI, Kauffman AS, Mellon PL. Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology. 2014 Oct; 155(10):4043-53. PMID: 25060364; PMCID: PMC4164932.
    21. Glidewell-Kenney CA, Trang C, Shao PP, Gutierrez-Reed N, Uzo-Okereke AM, Coss D, Mellon PL. Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology. 2014 Oct; 155(10):3909-19. PMID: 25057795; PMCID: PMC4164922.
    22. Breen KM, Mellon PL. Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):71-7. PMID: 24012628; PMCID: PMC3942370.
    23. Larder R, Kimura I, Meadows J, Clark DD, Mayo S, Mellon PL. Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol. 2013 Sep 05; 377(1-2):16-22. PMID: 23811236; PMCID: PMC3771655.
    24. Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Coss D, Kauffman AS, Mellon PL. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol. 2013 Aug; 27(8):1283-94. PMID: 23770611; PMCID: PMC3725344.
    25. Glidewell-Kenney CA, Shao PP, Iyer AK, Grove AM, Meadows JD, Mellon PL. Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol. 2013 Mar; 27(3):437-54. PMID: 23393128; PMCID: PMC3589675.
    26. Clark DD, Gorman MR, Hatori M, Meadows JD, Panda S, Mellon PL. Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J Biol Rhythms. 2013 Feb; 28(1):15-25. PMID: 23382588; PMCID: PMC3586279.
    27. Xie H, Cherrington BD, Meadows JD, Witham EA, Mellon PL. Msx1 homeodomain protein represses the aGSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol. 2013 Mar; 27(3):422-36. PMID: 23371388; PMCID: PMC3589667.
    28. Brayman MJ, Pepa PA, Mellon PL. Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol Cell Endocrinol. 2012 Nov 05; 363(1-2):92-9. PMID: 22877652; PMCID: PMC3447085.
    29. Breen KM, Thackray VG, Hsu T, Mak-McCully RA, Coss D, Mellon PL. Stress levels of glucocorticoids inhibit LHß-subunit gene expression in gonadotrope cells. Mol Endocrinol. 2012 Oct; 26(10):1716-31. PMID: 22851703; PMCID: PMC3458227.
    30. Witham EA, Meadows JD, Shojaei S, Kauffman AS, Mellon PL. Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 2012 Sep; 153(9):4522-32. PMID: 22778229; PMCID: PMC3423623.
    31. Ghochani Y, Saini JK, Mellon PL, Thackray VG. FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone ß-subunit promoter. Endocrinology. 2012 Apr; 153(4):2023-33. PMID: 22294749; PMCID: PMC3320250.
    32. Brayman MJ, Pepa PA, Berdy SE, Mellon PL. Androgen receptor repression of GnRH gene transcription. Mol Endocrinol. 2012 Jan; 26(1):2-13. PMID: 22074952; PMCID: PMC3248321.
    33. Lan D, Lu M, Sharma S, Mellon PL, Olefsky JM, Webster NJ. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHß gene expression by a SirT1-independent pathway in LßT2 gonadotrope cells. Reprod Toxicol. 2011 Jul; 32(1):85-92. PMID: 21679764; PMCID: PMC3155991.
    34. Beneduzzi D, Iyer AK, Trarbach EB, Silveira-Neto AP, Silveira LG, Tusset C, Yip K, Mendonça BB, Mellon PL, Latronico AC. Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2011 Jul; 165(1):145-50. PMID: 21543378; PMCID: PMC3203643.
    35. Yueh MF, Mellon PL, Tukey RH. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol. 2011 Jun; 79(6):1053-60. PMID: 21415305; PMCID: PMC3102552.
    36. Ely HA, Mellon PL, Coss D. GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. Mol Endocrinol. 2011 Apr; 25(4):669-80. PMID: 21292826; PMCID: PMC3063085.
    37. Iyer AK, Brayman MJ, Mellon PL. Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction. Mol Endocrinol. 2011 Mar; 25(3):460-73. PMID: 21239613; PMCID: PMC3045737.
    38. Larder R, Clark DD, Miller NL, Mellon PL. Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J Neurosci. 2011 Jan 12; 31(2):426-38. PMID: 21228153; PMCID: PMC3103738.
    39. Sharma S, Sharma PM, Mistry DS, Chang RJ, Olefsky JM, Mellon PL, Webster NJ. PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod. 2011 Mar; 84(3):466-75. PMID: 21076077; PMCID: PMC3043129.
    40. Iyer AK, Miller NL, Yip K, Tran BH, Mellon PL. Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression. Mol Endocrinol. 2010 Oct; 24(10):1949-64. PMID: 20667983; PMCID: PMC2954641.
    41. Coss D, Mellon PL, Thackray VG. A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab. 2010 Sep; 21(9):562-8. PMID: 20598900; PMCID: PMC2933269.
    42. Breen KM, Thackray VG, Coss D, Mellon PL. Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology. 2010 Jun; 151(6):2669-80. PMID: 20357224; PMCID: PMC2875819.
    43. Corpuz PS, Lindaman LL, Mellon PL, Coss D. FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes. Mol Endocrinol. 2010 May; 24(5):1037-51. PMID: 20233786; PMCID: PMC2870942.
    44. Thackray VG, Mellon PL, Coss D. Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol. 2010 Jan 27; 314(2):192-203. PMID: 19747958; PMCID: PMC2815122.
    45. Larder R, Mellon PL. Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem. 2009 Jun 19; 284(25):16966-78. PMID: 19401468; PMCID: PMC2719334.
    46. Thackray VG, Hunnicutt JL, Memon AK, Ghochani Y, Mellon PL. Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology. 2009 May; 150(5):2395-403. PMID: 19106225; PMCID: PMC2671912.
    47. Miller NL, Wevrick R, Mellon PL. Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development. Hum Mol Genet. 2009 Jan 15; 18(2):248-60. PMID: 18930956; PMCID: PMC2638776.
    48. Avelino-Cruz JE, Flores A, Cebada J, Mellon PL, Felix R, Monjaraz E. Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes. Mol Cell Endocrinol. 2009 Jan 27; 298(1-2):57-65. PMID: 18834922; PMCID: PMC2659688.
    49. Cherrington BD, Bailey JS, Diaz AL, Mellon PL. NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. Mol Cell Endocrinol. 2008 Nov 25; 295(1-2):106-14. PMID: 18760324; PMCID: PMC2640340.
    50. Sasson R, Luu SH, Thackray VG, Mellon PL. Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology. 2008 Jul; 149(7):3643-55. PMID: 18403486; PMCID: PMC2453092.
    51. McMahon HE, Hashimoto O, Mellon PL, Shimasaki S. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology. 2008 Jun; 149(6):2807-15. PMID: 18308851; PMCID: PMC2408818.
    52. Thackray VG, Mellon PL. Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology. 2008 Mar; 149(3):1091-102. PMID: 18079204; PMCID: PMC2275352.
    53. Lu M, Tang Q, Olefsky JM, Mellon PL, Webster NJ. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. PMID: 18006641; PMCID: PMC2262174.
    54. Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L, Jacobson-Dickman EE, Mellon PL, Zhou QY, Crowley WF. Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17447-52. PMID: 17959774; PMCID: PMC2077276.
    55. Coss D, Hand CM, Yaphockun KK, Ely HA, Mellon PL. p38 mitogen-activated protein kinase is critical for synergistic induction of the FSH(beta) gene by gonadotropin-releasing hormone and activin through augmentation of c-Fos induction and Smad phosphorylation. Mol Endocrinol. 2007 Dec; 21(12):3071-86. PMID: 17823303; PMCID: PMC2932484.
    56. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. PMID: 17299135; PMCID: PMC2932486.
    57. Sasson R, Dearth RK, White RS, Chappell PE, Mellon PL. Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons. Neuroendocrinology. 2006; 84(6):353-63. PMID: 17192702; PMCID: PMC2941430.
    58. McGillivray SM, Thackray VG, Coss D, Mellon PL. Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology. 2007 Feb; 148(2):762-73. PMID: 17082263; PMCID: PMC2932480.
    59. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. PMID: 16772531; PMCID: PMC2673912.
    60. Thackray VG, McGillivray SM, Mellon PL. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol. 2006 Sep; 20(9):2062-79. PMID: 16675544; PMCID: PMC2941439.
    61. Rave-Harel N, Miller NL, Givens ML, Mellon PL. The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem. 2005 Sep 02; 280(35):30975-83. PMID: 16002402; PMCID: PMC2773698.
    62. Tang Q, Mazur M, Mellon PL. The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells. Mol Endocrinol. 2005 Nov; 19(11):2769-79. PMID: 15994198; PMCID: PMC2935804.
    63. Coss D, Thackray VG, Deng CX, Mellon PL. Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol. 2005 Oct; 19(10):2610-23. PMID: 15961509; PMCID: PMC2932483.
    64. Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein JL, Robert B, Mellon PL. Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem. 2005 May 13; 280(19):19156-65. PMID: 15743757; PMCID: PMC2932481.
    65. McGillivray SM, Bailey JS, Ramezani R, Kirkwood BJ, Mellon PL. Mouse GnRH receptor gene expression is mediated by the LHX3 homeodomain protein. Endocrinology. 2005 May; 146(5):2180-5. PMID: 15705775; PMCID: PMC2930620.
    66. Givens ML, Kurotani R, Rave-Harel N, Miller NL, Mellon PL. Phylogenetic footprinting reveals evolutionarily conserved regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression. Mol Endocrinol. 2004 Dec; 18(12):2950-66. PMID: 15319450; PMCID: PMC2932476.
    67. Rave-Harel N, Givens ML, Nelson SB, Duong HA, Coss D, Clark ME, Hall SB, Kamps MP, Mellon PL. TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1. J Biol Chem. 2004 Jul 16; 279(29):30287-97. PMID: 15138251; PMCID: PMC2935805.
    68. Bailey JS, Rave-Harel N, McGillivray SM, Coss D, Mellon PL. Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol. 2004 May; 18(5):1158-70. PMID: 14764653; PMCID: PMC2935796.
    69. Spady TJ, Shayya R, Thackray VG, Ehrensberger L, Bailey JS, Mellon PL. Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol. 2004 Apr; 18(4):925-40. PMID: 14701939; PMCID: PMC2932479.
    70. Chappell PE, White RS, Mellon PL. Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci. 2003 Dec 03; 23(35):11202-13. PMID: 14657179; PMCID: PMC2932475.
    71. Coss D, Jacobs SB, Bender CE, Mellon PL. A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone. J Biol Chem. 2004 Jan 02; 279(1):152-62. PMID: 14570911; PMCID: PMC2930619.
    72. Pernasetti F, Spady TJ, Hall SB, Rosenberg SB, Givens ML, Anderson S, Paulus M, Miller WL, Mellon PL. Pituitary tumorigenesis targeted by the ovine follicle-stimulating hormone beta-subunit gene regulatory region in transgenic mice. Mol Cell Endocrinol. 2003 May 30; 203(1-2):169-83. PMID: 12782413.
      View in: PubMed
    73. Jacobs SB, Coss D, McGillivray SM, Mellon PL. Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene. Mol Endocrinol. 2003 Aug; 17(8):1470-83. PMID: 12730328; PMCID: PMC2933173.
    74. Kelley CG, Givens ML, Rave-Harel N, Nelson SB, Anderson S, Mellon PL. Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements. Mol Endocrinol. 2002 Nov; 16(11):2413-25. PMID: 12403831; PMCID: PMC2930614.
    75. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. PMID: 12193554; PMCID: PMC2932485.
    76. Arroyo A, Pernasetti F, Vasilyev VV, Amato P, Yen SS, Mellon PL. A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty. Clin Endocrinol (Oxf). 2002 Aug; 57(2):283-91. PMID: 12153609; PMCID: PMC2932477.
    77. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky JM, Webster NJ. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. PMID: 12050161; PMCID: PMC2930616.
    78. Rosenberg SB, Mellon PL. An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation. Mol Endocrinol. 2002 Jun; 16(6):1280-98. PMID: 12040015; PMCID: PMC2932471.
    79. Vasilyev VV, Pernasetti F, Rosenberg SB, Barsoum MJ, Austin DA, Webster NJ, Mellon PL. Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways. Endocrinology. 2002 May; 143(5):1651-9. PMID: 11956146; PMCID: PMC2930615.
    80. Holley SJ, Hall SB, Mellon PL. Complementary expression of IGF-II and IGFBP-5 during anterior pituitary development. Dev Biol. 2002 Apr 15; 244(2):319-28. PMID: 11944940.
      View in: PubMed
    81. Lawson MA, Macconell LA, Kim J, Powl BT, Nelson SB, Mellon PL. Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology. 2002 Apr; 143(4):1404-12. PMID: 11897697.
      View in: PubMed
    82. Liu F, Austin DA, Mellon PL, Olefsky JM, Webster NJ. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. PMID: 11875099.
      View in: PubMed
    83. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause. 2002 Mar-Apr; 9(2):145-50. PMID: 11875334.
      View in: PubMed
    84. Pernasetti F, Vasilyev VV, Rosenberg SB, Bailey JS, Huang HJ, Miller WL, Mellon PL. Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model. Endocrinology. 2001 Jun; 142(6):2284-95. PMID: 11356674.
      View in: PubMed
    85. Dardick I, Ho J, Paulus M, Mellon PL, Mirels L. Submandibular gland adenocarcinoma of intercalated duct origin in Smgb-Tag mice. Lab Invest. 2000 Nov; 80(11):1657-70. PMID: 11092526.
      View in: PubMed
    86. Sosnowski R, Mellon PL, Lawson MA. Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. Mol Endocrinol. 2000 Nov; 14(11):1811-9. PMID: 11075814.
      View in: PubMed
    87. Nelson SB, Lawson MA, Kelley CG, Mellon PL. Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol. 2000 Sep; 14(9):1509-22. PMID: 10976927.
      View in: PubMed
    88. Kelley CG, Lavorgna G, Clark ME, Boncinelli E, Mellon PL. The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter. Mol Endocrinol. 2000 Aug; 14(8):1246-56. PMID: 10935548.
      View in: PubMed
    89. LiCalsi C, Christophe S, Steger DJ, Buescher M, Fischer W, Mellon PL. AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin. Nucleic Acids Res. 2000 Feb 15; 28(4):1036-43. PMID: 10648798; PMCID: PMC102581.
    90. Belsham DD, Mellon PL. Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/cyclic-guanosine 5'-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression. Mol Endocrinol. 2000 Feb; 14(2):212-28. PMID: 10674395.
      View in: PubMed
    91. Pernasetti F, Toledo SP, Vasilyev VV, Hayashida CY, Cogan JD, Ferrari C, Lourenço DM, Mellon PL. Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene. J Clin Endocrinol Metab. 2000 Jan; 85(1):390-7. PMID: 10634415.
      View in: PubMed
    92. Anderson RA, Zwain IH, Arroyo A, Mellon PL, Yen SS. The insulin-like growth factor system in the GT1-7 GnRH neuronal cell line. Neuroendocrinology. 1999 Nov; 70(5):353-9. PMID: 10567861.
      View in: PubMed
    93. Kurotani R, Tahara S, Sanno N, Teramoto A, Mellon PL, Inoue K, Yoshimura S, Osamura RY. Expression of ptx1 in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells Cell Tissue Res. 1999 Oct; 298(1):55-61. PMID: 10502117.
      View in: PubMed
    94. MacConell LA, Lawson MA, Mellon PL, Roberts VJ. Activin A regulation of gonadotropin-releasing hormone synthesis and release in vitro. Neuroendocrinology. 1999 Oct; 70(4):246-54. PMID: 10529619.
      View in: PubMed
    95. Kurotani R, Tahara S, Sanno N, Teramoto A, Mellon PL, Inoue K, Yoshimura S, Osamura RY. Expression of Ptx1 in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells. Cell Tissue Res. 1999 Oct; 298(1):55-61. PMID: 10555539.
      View in: PubMed
    96. Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL. The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells. Endocrinology. 1998 Nov; 139(11):4476-82. PMID: 9794455.
      View in: PubMed
    97. Alarid ET, Holley S, Hayakawa M, Mellon PL. Discrete stages of anterior pituitary differentiation recapitulated in immortalized cell lines. Mol Cell Endocrinol. 1998 May 25; 140(1-2):25-30. PMID: 9722164.
      View in: PubMed
    98. Nelson SB, Eraly SA, Mellon PL. The GnRH promoter: target of transcription factors, hormones, and signaling pathways. Mol Cell Endocrinol. 1998 May 25; 140(1-2):151-5. PMID: 9722183.
      View in: PubMed
    99. Lawson MA, Mellon PL. Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse. Mol Cell Endocrinol. 1998 May 25; 140(1-2):157-61. PMID: 9722184.
      View in: PubMed
    100. Harris AN, Mellon PL. The basic helix-loop-helix, leucine zipper transcription factor, USF (upstream stimulatory factor), is a key regulator of SF-1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells. Mol Endocrinol. 1998 May; 12(5):714-26. PMID: 9605934.
      View in: PubMed
    101. Eraly SA, Nelson SB, Huang KM, Mellon PL. Oct-1 binds promoter elements required for transcription of the GnRH gene. Mol Endocrinol. 1998 Apr; 12(4):469-81. PMID: 9544983.
      View in: PubMed
    102. Lawson MA, Buhain AR, Jovenal JC, Mellon PL. Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol. 1998 Mar; 12(3):364-77. PMID: 9514154.
      View in: PubMed
    103. Alarid ET, Windle JJ, Whyte DB, Mellon PL. Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development. 1996 Oct; 122(10):3319-29. PMID: 8898243.
      View in: PubMed
    104. Thomas P, Mellon PL, Turgeon J, Waring DW. The L beta T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion. Endocrinology. 1996 Jul; 137(7):2979-89. PMID: 8770922.
      View in: PubMed
    105. Lawson MA, Whyte DB, Mellon PL. GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol Cell Biol. 1996 Jul; 16(7):3596-605. PMID: 8668176; PMCID: PMC231355.
    106. Turgeon JL, Kimura Y, Waring DW, Mellon PL. Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Mol Endocrinol. 1996 Apr; 10(4):439-50. PMID: 8721988.
      View in: PubMed
    107. Belsham DD, Wetsel WC, Mellon PL. NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. EMBO J. 1996 Feb 01; 15(3):538-47. PMID: 8599937; PMCID: PMC449972.
    108. Clark ME, Mellon PL. The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol Cell Biol. 1995 Nov; 15(11):6169-77. PMID: 7565769; PMCID: PMC230868.
    109. Ben-Menahem D, Shraga-Levine Z, Mellon PL, Naor Z. Mechanism of action of gonadotropin-releasing hormone upon gonadotropin alpha-subunit mRNA levels in the alpha T3-1 cell line: role of Ca2+ and protein kinase C. Biochem J. 1995 Jul 01; 309 ( Pt 1):325-9. PMID: 7542447; PMCID: PMC1135837.
    110. Eraly SA, Mellon PL. Regulation of gonadotropin-releasing hormone transcription by protein kinase C is mediated by evolutionarily conserved promoter-proximal elements. Mol Endocrinol. 1995 Jul; 9(7):848-59. PMID: 7476968.
      View in: PubMed
    111. Schechter J, Stauber C, Windle JJ, Mellon P. Basic fibroblast growth factor: the neurotrophic factor influencing the ingrowth of neural tissue into the anterior pituitary of alpha-T7 transgenic mice? Neuroendocrinology. 1995 Jun; 61(6):622-7. PMID: 7659188.
      View in: PubMed
    112. Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP, Mellon PL. A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol Endocrinol. 1995 Apr; 9(4):467-77. PMID: 7659090.
      View in: PubMed
    113. Alarid ET, Mellon PL. Down-regulation of the gonadotropin-releasing hormone receptor messenger ribonucleic acid by activation of adenylyl cyclase in alpha T3-1 pituitary gonadotrope cells. Endocrinology. 1995 Apr; 136(4):1361-6. PMID: 7895646.
      View in: PubMed
    114. Lawson MA, Whyte DB, Eraly SA, Mellon PL. Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog Horm Res. 1995; 50:459-63. PMID: 7740182.
      View in: PubMed