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Pamela Mellon

Title(s)Professor, Reproductive Medicine
SchoolHealth Sciences
Phone858-534-1312
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    Other Positions
    Title(s)Professor of Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, Berkeley, CaliforniaPhD06/1979Molecular Biology
    California Institute of Technology, Pasadena, CaliforniaPostdoctoral12/1980Biology
    Harvard University, Cambridge, MassachusettsPostdoctoral08/1984Biochemistry and Molecular Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Neuroendocrine Actions of Androgens in Female Reproduction
    NIH/NICHD R01HD082567Apr 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Endocrine and Growth Factor Regulation in the Pituitary
    NIH/NIDDK R01DK068121Mar 1, 2005 - Mar 31, 2005
    Role: Principal Investigator
    Diabetes Research Center (DRC)
    NIH/NIDDK P30DK063491Dec 1, 2002 - Jun 30, 2020
    Role: Co-Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    GORDON CONFERENCE ON HORMONE ACTION
    NIH/NIDDK R13DK050196Jul 28, 1995 - Jul 27, 1996
    Role: Principal Investigator
    DIVISION OF PHYSIOLOGY AND PATHOLOGY
    NIH/CSR U09RG000146Jul 1, 1994 - Sep 29, 2006
    Role: Principal Investigator
    Neurosecretory Gene Expression in the Hypothalamus
    NIH/NICHD R01HD072754Jan 1, 1992 - Jun 30, 2017
    Role: Principal Investigator
    CELL LINEAGE IN THE ANTERIOR PITUITARY
    NIH/NICHD R37HD020377Jan 1, 1992 - Jul 31, 2006
    Role: Principal Investigator
    Neurosecretory Gene Expression in the Hypothalamus
    NIH/NIDDK R01DK044838Jul 1, 1991 - Aug 31, 2012
    Role: Principal Investigator
    GLYCOPROTEIN HORMONE ALPHA SUBUNIT &GENE TRANSCRIPTION
    NIH/NICHD R01HD023818Feb 1, 1988 - Jul 31, 1993
    Role: Principal Investigator
    LUTEINIZING HORMONE IN ENDOCRINE &REPRODUCTIVE DISEASES
    NIH/NIDDK R03DK039798Sep 1, 1987 - Aug 31, 1988
    Role: Principal Investigator
    Molecular Mechanisms of Gonadotrope Differentiation
    NIH/NICHD R01HD020377Jul 1, 1985 - Jun 30, 2012
    Role: Principal Investigator
    Training in Reproductive Sciences
    NIH/NICHD T32HD007203Jul 1, 1979 - Apr 30, 2023
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH/NICHD P50HD012303Dec 1, 1978 - Mar 31, 2021
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH/NICHD U54HD012303Dec 1, 1978 - Mar 31, 2014
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL. Deletion of the Homeodomain Protein Six6 from GnRH Neurons Decreases GnRH Gene Expression Resulting in Infertility. Endocrinology. 2019 Jun 18. PMID: 31211355.
      View in: PubMed
    2. Ruf-Zamojski F, Ge Y, Pincas H, Shan J, Song Y, Hines N, Kelley K, Montagna C, Nair P, Toufaily C, Bernard DJ, Mellon PL, Nair V, Turgeon JL, Sealfon SC. Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines. J Endocr Soc. 2019 May 01; 3(5):902-920. PMID: 31020055.
      View in: PubMed
    3. Tonsfeldt KJ, Schoeller EL, Brusman LE, Cui LJ, Lee J, Mellon PL. The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc. 2019 Apr 01; 3(4):716-733. PMID: 30906911.
      View in: PubMed
    4. Hoffmann HM, Larder R, Lee JS, Hu RJ, Trang C, Devries BM, Clark DD, Mellon PL. Differential CRE expression in Lhrh-Cre and Gnrh-Cre alleles and the impact on fertility in Otx2-flox mice. Neuroendocrinology. 2019 Feb 10. PMID: 30739114.
      View in: PubMed
    5. Hoffmann H, Pandolfi E, Larder R, Mellon P. Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2, Causes Subfertility in Mice Via Distinct Mechanisms. Neuroendocrinology. 2018 Sep 27. PMID: 30261489.
      View in: PubMed
    6. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. PMID: 30013121.
      View in: PubMed
    7. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. PMID: 29875409.
      View in: PubMed
    8. Ryan GE, Malik S, Mellon PL. Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. Endocrinology. 2018 04 01; 159(4):1734-1747. PMID: 29471436.
      View in: PubMed
    9. Pandolfi EC, Hoffmann HM, Schoeller EL, Gorman MR, Mellon PL. Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol. 2018 Nov; 55(11):8709-8727. PMID: 29589282.
      View in: PubMed
    10. Xie H, Hoffmann HM, Iyer AK, Brayman MJ, Ngo C, Sunshine MJ, Mellon PL. Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol. 2017 Oct 24; 15(1):86. PMID: 29065928.
      View in: PubMed
    11. Hoffmann HM, Gong P, Tamrazian A, Mellon PL. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol. 2018 02 05; 461:143-154. PMID: 28890143.
      View in: PubMed
    12. Schoeller EL, Clark DD, Dey S, Cao NV, Semaan SJ, Chao LW, Kauffman AS, Stowers L, Mellon PL. Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology. 2016 Dec; 157(12):4914-4929. PMID: 27704948.
      View in: PubMed
    13. Hoffmann HM, Mellon PL. A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. Neurosci Commun (Houst). 2016; 2. PMID: 28164172.
      View in: PubMed
    14. Huang PP, Brusman LE, Iyer AK, Webster NJ, Mellon PL. A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. PLoS One. 2016; 11(7):e0158597. PMID: 27389022.
      View in: PubMed
    15. Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC, Mellon PL. Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci. 2016 Mar 23; 36(12):3506-18. PMID: 27013679.
      View in: PubMed
    16. Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zheng L, Krawczyk M, Chen D, Shi C, Zin C, Zhu J, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong S, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K. P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Mol Cell. 2015 Sep 17; 59(6):931-40. PMID: 26365380.
      View in: PubMed
    17. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175.
      View in: PubMed
    18. Stephens SB, Tolson KP, Rouse ML, Poling MC, Hashimoto-Partyka MK, Mellon PL, Kauffman AS. Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice. Endocrinology. 2015 Sep; 156(9):3091-7. PMID: 26076042.
      View in: PubMed
    19. Xie H, Hoffmann HM, Meadows JD, Mayo SL, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon PL. Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. Mol Endocrinol. 2015 Jun; 29(6):842-55. PMID: 25915183.
      View in: PubMed
    20. Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon PL, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV. KISS1R signals independently of Gaq/11 and triggers LH secretion via the ß-arrestin pathway in the male mouse. Endocrinology. 2014 Nov; 155(11):4433-46. PMID: 25147978.
      View in: PubMed
    21. Roybal LL, Hambarchyan A, Meadows JD, Barakat NH, Pepa PA, Breen KM, Mellon PL, Coss D. Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHß. Mol Endocrinol. 2014 Oct; 28(10):1640-55. PMID: 25105693.
      View in: PubMed
    22. Hoffmann HM, Tamrazian A, Xie H, Pérez-Millán MI, Kauffman AS, Mellon PL. Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology. 2014 Oct; 155(10):4043-53. PMID: 25060364.
      View in: PubMed
    23. Glidewell-Kenney CA, Trang C, Shao PP, Gutierrez-Reed N, Uzo-Okereke AM, Coss D, Mellon PL. Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology. 2014 Oct; 155(10):3909-19. PMID: 25057795.
      View in: PubMed
    24. Breen KM, Mellon PL. Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):71-7. PMID: 24012628.
      View in: PubMed
    25. Larder R, Kimura I, Meadows J, Clark DD, Mayo S, Mellon PL. Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol. 2013 Sep 05; 377(1-2):16-22. PMID: 23811236.
      View in: PubMed
    26. Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Coss D, Kauffman AS, Mellon PL. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol. 2013 Aug; 27(8):1283-94. PMID: 23770611.
      View in: PubMed
    27. Glidewell-Kenney CA, Shao PP, Iyer AK, Grove AM, Meadows JD, Mellon PL. Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol. 2013 Mar; 27(3):437-54. PMID: 23393128.
      View in: PubMed
    28. Clark DD, Gorman MR, Hatori M, Meadows JD, Panda S, Mellon PL. Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J Biol Rhythms. 2013 Feb; 28(1):15-25. PMID: 23382588.
      View in: PubMed
    29. Xie H, Cherrington BD, Meadows JD, Witham EA, Mellon PL. Msx1 homeodomain protein represses the aGSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol. 2013 Mar; 27(3):422-36. PMID: 23371388.
      View in: PubMed
    30. Brayman MJ, Pepa PA, Mellon PL. Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol Cell Endocrinol. 2012 Nov 05; 363(1-2):92-9. PMID: 22877652.
      View in: PubMed
    31. Breen KM, Thackray VG, Hsu T, Mak-McCully RA, Coss D, Mellon PL. Stress levels of glucocorticoids inhibit LHß-subunit gene expression in gonadotrope cells. Mol Endocrinol. 2012 Oct; 26(10):1716-31. PMID: 22851703.
      View in: PubMed
    32. Witham EA, Meadows JD, Shojaei S, Kauffman AS, Mellon PL. Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 2012 Sep; 153(9):4522-32. PMID: 22778229.
      View in: PubMed
    33. Ghochani Y, Saini JK, Mellon PL, Thackray VG. FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone ß-subunit promoter. Endocrinology. 2012 Apr; 153(4):2023-33. PMID: 22294749.
      View in: PubMed
    34. Brayman MJ, Pepa PA, Berdy SE, Mellon PL. Androgen receptor repression of GnRH gene transcription. Mol Endocrinol. 2012 Jan; 26(1):2-13. PMID: 22074952.
      View in: PubMed
    35. Lan D, Lu M, Sharma S, Mellon PL, Olefsky JM, Webster NJ. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHß gene expression by a SirT1-independent pathway in LßT2 gonadotrope cells. Reprod Toxicol. 2011 Jul; 32(1):85-92. PMID: 21679764.
      View in: PubMed
    36. Beneduzzi D, Iyer AK, Trarbach EB, Silveira-Neto AP, Silveira LG, Tusset C, Yip K, Mendonça BB, Mellon PL, Latronico AC. Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2011 Jul; 165(1):145-50. PMID: 21543378.
      View in: PubMed
    37. Yueh MF, Mellon PL, Tukey RH. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol. 2011 Jun; 79(6):1053-60. PMID: 21415305.
      View in: PubMed
    38. Ely HA, Mellon PL, Coss D. GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. Mol Endocrinol. 2011 Apr; 25(4):669-80. PMID: 21292826.
      View in: PubMed
    39. Iyer AK, Brayman MJ, Mellon PL. Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction. Mol Endocrinol. 2011 Mar; 25(3):460-73. PMID: 21239613.
      View in: PubMed
    40. Larder R, Clark DD, Miller NL, Mellon PL. Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J Neurosci. 2011 Jan 12; 31(2):426-38. PMID: 21228153.
      View in: PubMed
    41. Sharma S, Sharma PM, Mistry DS, Chang RJ, Olefsky JM, Mellon PL, Webster NJ. PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod. 2011 Mar; 84(3):466-75. PMID: 21076077.
      View in: PubMed
    42. Iyer AK, Miller NL, Yip K, Tran BH, Mellon PL. Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression. Mol Endocrinol. 2010 Oct; 24(10):1949-64. PMID: 20667983.
      View in: PubMed
    43. Coss D, Mellon PL, Thackray VG. A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab. 2010 Sep; 21(9):562-8. PMID: 20598900.
      View in: PubMed
    44. Breen KM, Thackray VG, Coss D, Mellon PL. Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology. 2010 Jun; 151(6):2669-80. PMID: 20357224.
      View in: PubMed
    45. Corpuz PS, Lindaman LL, Mellon PL, Coss D. FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes. Mol Endocrinol. 2010 May; 24(5):1037-51. PMID: 20233786.
      View in: PubMed
    46. Thackray VG, Mellon PL, Coss D. Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol. 2010 Jan 27; 314(2):192-203. PMID: 19747958.
      View in: PubMed
    47. Larder R, Mellon PL. Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem. 2009 Jun 19; 284(25):16966-78. PMID: 19401468.
      View in: PubMed
    48. Thackray VG, Hunnicutt JL, Memon AK, Ghochani Y, Mellon PL. Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology. 2009 May; 150(5):2395-403. PMID: 19106225.
      View in: PubMed
    49. Miller NL, Wevrick R, Mellon PL. Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development. Hum Mol Genet. 2009 Jan 15; 18(2):248-60. PMID: 18930956.
      View in: PubMed
    50. Avelino-Cruz JE, Flores A, Cebada J, Mellon PL, Felix R, Monjaraz E. Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes. Mol Cell Endocrinol. 2009 Jan 27; 298(1-2):57-65. PMID: 18834922.
      View in: PubMed
    51. Cherrington BD, Bailey JS, Diaz AL, Mellon PL. NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. Mol Cell Endocrinol. 2008 Nov 25; 295(1-2):106-14. PMID: 18760324.
      View in: PubMed
    52. Sasson R, Luu SH, Thackray VG, Mellon PL. Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology. 2008 Jul; 149(7):3643-55. PMID: 18403486.
      View in: PubMed
    53. McMahon HE, Hashimoto O, Mellon PL, Shimasaki S. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology. 2008 Jun; 149(6):2807-15. PMID: 18308851.
      View in: PubMed
    54. Thackray VG, Mellon PL. Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology. 2008 Mar; 149(3):1091-102. PMID: 18079204.
      View in: PubMed
    55. Lu M, Tang Q, Olefsky JM, Mellon PL, Webster NJ. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. PMID: 18006641.
      View in: PubMed
    56. Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L, Jacobson-Dickman EE, Mellon PL, Zhou QY, Crowley WF. Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17447-52. PMID: 17959774.
      View in: PubMed
    57. Coss D, Hand CM, Yaphockun KK, Ely HA, Mellon PL. p38 mitogen-activated protein kinase is critical for synergistic induction of the FSH(beta) gene by gonadotropin-releasing hormone and activin through augmentation of c-Fos induction and Smad phosphorylation. Mol Endocrinol. 2007 Dec; 21(12):3071-86. PMID: 17823303.
      View in: PubMed
    58. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. PMID: 17299135.
      View in: PubMed
    59. Sasson R, Dearth RK, White RS, Chappell PE, Mellon PL. Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons. Neuroendocrinology. 2006; 84(6):353-63. PMID: 17192702.
      View in: PubMed
    60. McGillivray SM, Thackray VG, Coss D, Mellon PL. Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology. 2007 Feb; 148(2):762-73. PMID: 17082263.
      View in: PubMed
    61. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. PMID: 16772531.
      View in: PubMed
    62. Thackray VG, McGillivray SM, Mellon PL. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol. 2006 Sep; 20(9):2062-79. PMID: 16675544.
      View in: PubMed
    63. Rave-Harel N, Miller NL, Givens ML, Mellon PL. The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem. 2005 Sep 02; 280(35):30975-83. PMID: 16002402.
      View in: PubMed
    64. Tang Q, Mazur M, Mellon PL. The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells. Mol Endocrinol. 2005 Nov; 19(11):2769-79. PMID: 15994198.
      View in: PubMed
    65. Coss D, Thackray VG, Deng CX, Mellon PL. Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol. 2005 Oct; 19(10):2610-23. PMID: 15961509.
      View in: PubMed
    66. Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein JL, Robert B, Mellon PL. Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem. 2005 May 13; 280(19):19156-65. PMID: 15743757.
      View in: PubMed
    67. McGillivray SM, Bailey JS, Ramezani R, Kirkwood BJ, Mellon PL. Mouse GnRH receptor gene expression is mediated by the LHX3 homeodomain protein. Endocrinology. 2005 May; 146(5):2180-5. PMID: 15705775.
      View in: PubMed
    68. Givens ML, Kurotani R, Rave-Harel N, Miller NL, Mellon PL. Phylogenetic footprinting reveals evolutionarily conserved regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression. Mol Endocrinol. 2004 Dec; 18(12):2950-66. PMID: 15319450.
      View in: PubMed
    69. Rave-Harel N, Givens ML, Nelson SB, Duong HA, Coss D, Clark ME, Hall SB, Kamps MP, Mellon PL. TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1. J Biol Chem. 2004 Jul 16; 279(29):30287-97. PMID: 15138251.
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    70. Bailey JS, Rave-Harel N, McGillivray SM, Coss D, Mellon PL. Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol. 2004 May; 18(5):1158-70. PMID: 14764653.
      View in: PubMed
    71. Spady TJ, Shayya R, Thackray VG, Ehrensberger L, Bailey JS, Mellon PL. Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol. 2004 Apr; 18(4):925-40. PMID: 14701939.
      View in: PubMed
    72. Chappell PE, White RS, Mellon PL. Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci. 2003 Dec 03; 23(35):11202-13. PMID: 14657179.
      View in: PubMed
    73. Coss D, Jacobs SB, Bender CE, Mellon PL. A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone. J Biol Chem. 2004 Jan 02; 279(1):152-62. PMID: 14570911.
      View in: PubMed
    74. Pernasetti F, Spady TJ, Hall SB, Rosenberg SB, Givens ML, Anderson S, Paulus M, Miller WL, Mellon PL. Pituitary tumorigenesis targeted by the ovine follicle-stimulating hormone beta-subunit gene regulatory region in transgenic mice. Mol Cell Endocrinol. 2003 May 30; 203(1-2):169-83. PMID: 12782413.
      View in: PubMed
    75. Jacobs SB, Coss D, McGillivray SM, Mellon PL. Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene. Mol Endocrinol. 2003 Aug; 17(8):1470-83. PMID: 12730328.
      View in: PubMed
    76. Kelley CG, Givens ML, Rave-Harel N, Nelson SB, Anderson S, Mellon PL. Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements. Mol Endocrinol. 2002 Nov; 16(11):2413-25. PMID: 12403831.
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    77. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. PMID: 12193554.
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    78. Arroyo A, Pernasetti F, Vasilyev VV, Amato P, Yen SS, Mellon PL. A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty. Clin Endocrinol (Oxf). 2002 Aug; 57(2):283-91. PMID: 12153609.
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    79. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky JM, Webster NJ. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. PMID: 12050161.
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    80. Rosenberg SB, Mellon PL. An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation. Mol Endocrinol. 2002 Jun; 16(6):1280-98. PMID: 12040015.
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    81. Vasilyev VV, Pernasetti F, Rosenberg SB, Barsoum MJ, Austin DA, Webster NJ, Mellon PL. Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways. Endocrinology. 2002 May; 143(5):1651-9. PMID: 11956146.
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    82. Holley SJ, Hall SB, Mellon PL. Complementary expression of IGF-II and IGFBP-5 during anterior pituitary development. Dev Biol. 2002 Apr 15; 244(2):319-28. PMID: 11944940.
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    83. Lawson MA, Macconell LA, Kim J, Powl BT, Nelson SB, Mellon PL. Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology. 2002 Apr; 143(4):1404-12. PMID: 11897697.
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    84. Liu F, Austin DA, Mellon PL, Olefsky JM, Webster NJ. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. PMID: 11875099.
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    85. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause. 2002 Mar-Apr; 9(2):145-50. PMID: 11875334.
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    86. Pernasetti F, Vasilyev VV, Rosenberg SB, Bailey JS, Huang HJ, Miller WL, Mellon PL. Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model. Endocrinology. 2001 Jun; 142(6):2284-95. PMID: 11356674.
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    87. Dardick I, Ho J, Paulus M, Mellon PL, Mirels L. Submandibular gland adenocarcinoma of intercalated duct origin in Smgb-Tag mice. Lab Invest. 2000 Nov; 80(11):1657-70. PMID: 11092526.
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    88. Sosnowski R, Mellon PL, Lawson MA. Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. Mol Endocrinol. 2000 Nov; 14(11):1811-9. PMID: 11075814.
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    89. Nelson SB, Lawson MA, Kelley CG, Mellon PL. Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol. 2000 Sep; 14(9):1509-22. PMID: 10976927.
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    90. Kelley CG, Lavorgna G, Clark ME, Boncinelli E, Mellon PL. The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter. Mol Endocrinol. 2000 Aug; 14(8):1246-56. PMID: 10935548.
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    91. LiCalsi C, Christophe S, Steger DJ, Buescher M, Fischer W, Mellon PL. AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin. Nucleic Acids Res. 2000 Feb 15; 28(4):1036-43. PMID: 10648798.
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    92. Belsham DD, Mellon PL. Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/cyclic-guanosine 5'-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression. Mol Endocrinol. 2000 Feb; 14(2):212-28. PMID: 10674395.
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    93. Pernasetti F, Toledo SP, Vasilyev VV, Hayashida CY, Cogan JD, Ferrari C, Lourenço DM, Mellon PL. Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene. J Clin Endocrinol Metab. 2000 Jan; 85(1):390-7. PMID: 10634415.
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    94. Anderson RA, Zwain IH, Arroyo A, Mellon PL, Yen SS. The insulin-like growth factor system in the GT1-7 GnRH neuronal cell line. Neuroendocrinology. 1999 Nov; 70(5):353-9. PMID: 10567861.
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    95. Kurotani R, Tahara S, Sanno N, Teramoto A, Mellon PL, Inoue K, Yoshimura S, Osamura RY. Expression of ptx1 in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells Cell Tissue Res. 1999 Oct; 298(1):55-61. PMID: 10502117.
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    96. MacConell LA, Lawson MA, Mellon PL, Roberts VJ. Activin A regulation of gonadotropin-releasing hormone synthesis and release in vitro. Neuroendocrinology. 1999 Oct; 70(4):246-54. PMID: 10529619.
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    97. Kurotani R, Tahara S, Sanno N, Teramoto A, Mellon PL, Inoue K, Yoshimura S, Osamura RY. Expression of Ptx1 in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells. Cell Tissue Res. 1999 Oct; 298(1):55-61. PMID: 10555539.
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    98. Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL. The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells. Endocrinology. 1998 Nov; 139(11):4476-82. PMID: 9794455.
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    99. Alarid ET, Holley S, Hayakawa M, Mellon PL. Discrete stages of anterior pituitary differentiation recapitulated in immortalized cell lines. Mol Cell Endocrinol. 1998 May 25; 140(1-2):25-30. PMID: 9722164.
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    100. Nelson SB, Eraly SA, Mellon PL. The GnRH promoter: target of transcription factors, hormones, and signaling pathways. Mol Cell Endocrinol. 1998 May 25; 140(1-2):151-5. PMID: 9722183.
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    101. Lawson MA, Mellon PL. Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse. Mol Cell Endocrinol. 1998 May 25; 140(1-2):157-61. PMID: 9722184.
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    102. Harris AN, Mellon PL. The basic helix-loop-helix, leucine zipper transcription factor, USF (upstream stimulatory factor), is a key regulator of SF-1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells. Mol Endocrinol. 1998 May; 12(5):714-26. PMID: 9605934.
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    103. Eraly SA, Nelson SB, Huang KM, Mellon PL. Oct-1 binds promoter elements required for transcription of the GnRH gene. Mol Endocrinol. 1998 Apr; 12(4):469-81. PMID: 9544983.
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    104. Lawson MA, Buhain AR, Jovenal JC, Mellon PL. Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol. 1998 Mar; 12(3):364-77. PMID: 9514154.
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    105. Alarid ET, Windle JJ, Whyte DB, Mellon PL. Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development. 1996 Oct; 122(10):3319-29. PMID: 8898243.
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    106. Thomas P, Mellon PL, Turgeon J, Waring DW. The L beta T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion. Endocrinology. 1996 Jul; 137(7):2979-89. PMID: 8770922.
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    107. Lawson MA, Whyte DB, Mellon PL. GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol Cell Biol. 1996 Jul; 16(7):3596-605. PMID: 8668176.
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    108. Turgeon JL, Kimura Y, Waring DW, Mellon PL. Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Mol Endocrinol. 1996 Apr; 10(4):439-50. PMID: 8721988.
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    109. Belsham DD, Wetsel WC, Mellon PL. NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. EMBO J. 1996 Feb 01; 15(3):538-47. PMID: 8599937.
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    110. Clark ME, Mellon PL. The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol Cell Biol. 1995 Nov; 15(11):6169-77. PMID: 7565769.
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    111. Ben-Menahem D, Shraga-Levine Z, Mellon PL, Naor Z. Mechanism of action of gonadotropin-releasing hormone upon gonadotropin alpha-subunit mRNA levels in the alpha T3-1 cell line: role of Ca2+ and protein kinase C. Biochem J. 1995 Jul 01; 309 ( Pt 1):325-9. PMID: 7542447.
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    112. Eraly SA, Mellon PL. Regulation of gonadotropin-releasing hormone transcription by protein kinase C is mediated by evolutionarily conserved promoter-proximal elements. Mol Endocrinol. 1995 Jul; 9(7):848-59. PMID: 7476968.
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    113. Schechter J, Stauber C, Windle JJ, Mellon P. Basic fibroblast growth factor: the neurotrophic factor influencing the ingrowth of neural tissue into the anterior pituitary of alpha-T7 transgenic mice? Neuroendocrinology. 1995 Jun; 61(6):622-7. PMID: 7659188.
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    114. Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP, Mellon PL. A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol Endocrinol. 1995 Apr; 9(4):467-77. PMID: 7659090.
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    115. Alarid ET, Mellon PL. Down-regulation of the gonadotropin-releasing hormone receptor messenger ribonucleic acid by activation of adenylyl cyclase in alpha T3-1 pituitary gonadotrope cells. Endocrinology. 1995 Apr; 136(4):1361-6. PMID: 7895646.
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    116. Lawson MA, Whyte DB, Eraly SA, Mellon PL. Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog Horm Res. 1995; 50:459-63. PMID: 7740182.
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    117. Steger DJ, Hecht JH, Mellon PL. GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland. Mol Cell Biol. 1994 Aug; 14(8):5592-602. PMID: 7518566.
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    118. Barnhart KM, Mellon PL. The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone alpha-subunit gene in pituitary gonadotropes. Mol Endocrinol. 1994 Jul; 8(7):878-85. PMID: 7527122.
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    119. Barnhart KM, Mellon PL. The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16; 142(2):313-4. PMID: 8194772.
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    120. Steger DJ, Büscher M, Hecht JH, Mellon PL. Coordinate control of the alpha- and beta-subunit genes of human chorionic gonadotropin by trophoblast-specific element-binding protein. Mol Endocrinol. 1993 Dec; 7(12):1579-88. PMID: 7511787.
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    121. Jackson SM, Barnhart KM, Mellon PL, Gutierrez-Hartmann A, Hoeffler JP. Helix-loop-helix proteins are present and differentially expressed in different cell lines from the anterior pituitary. Mol Cell Endocrinol. 1993 Oct; 96(1-2):167-76. PMID: 8276132.
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    122. Bignon YJ, Chen Y, Chang CY, Riley DJ, Windle JJ, Mellon PL, Lee WH. Expression of a retinoblastoma transgene results in dwarf mice. Genes Dev. 1993 Sep; 7(9):1654-62. PMID: 8370518.
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    123. Wetsel WC, Eraly SA, Whyte DB, Mellon PL. Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons. Endocrinology. 1993 Jun; 132(6):2360-70. PMID: 8504741.
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    124. Lew D, Brady H, Klausing K, Yaginuma K, Theill LE, Stauber C, Karin M, Mellon PL. GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice. Genes Dev. 1993 Apr; 7(4):683-93. PMID: 8096199.
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    125. Schechter J, Windle JJ, Stauber C, Mellon PL. Neural tissue within anterior pituitary tumors generated by oncogene expression in transgenic mice. Neuroendocrinology. 1992 Sep; 56(3):300-11. PMID: 1331836.
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    126. Merelli F, Stojilkovic SS, Iida T, Krsmanovic LZ, Zheng L, Mellon PL, Catt KJ. Gonadotropin-releasing hormone-induced calcium signaling in clonal pituitary gonadotrophs. Endocrinology. 1992 Aug; 131(2):925-32. PMID: 1379169.
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    127. Tsutsumi M, Zhou W, Millar RP, Mellon PL, Roberts JL, Flanagan CA, Dong K, Gillo B, Sealfon SC. Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol Endocrinol. 1992 Jul; 6(7):1163-9. PMID: 1324422.
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    128. Schoderbek WE, Kim KE, Ridgway EC, Mellon PL, Maurer RA. Analysis of DNA sequences required for pituitary-specific expression of the glycoprotein hormone alpha-subunit gene. Mol Endocrinol. 1992 Jun; 6(6):893-903. PMID: 1379672.
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    129. Horn F, Windle JJ, Barnhart KM, Mellon PL. Tissue-specific gene expression in the pituitary: the glycoprotein hormone alpha-subunit gene is regulated by a gonadotrope-specific protein. Mol Cell Biol. 1992 May; 12(5):2143-53. PMID: 1373809.
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    130. Stauber C, Altschmied J, Akerblom IE, Marron JL, Mellon PL. Mutual cross-interference between glucocorticoid receptor and CREB inhibits transactivation in placental cells. New Biol. 1992 May; 4(5):527-40. PMID: 1387550.
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    131. Wetsel WC, Valença MM, Merchenthaler I, Liposits Z, López FJ, Weiner RI, Mellon PL, Negro-Vilar A. Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons. Proc Natl Acad Sci U S A. 1992 May 01; 89(9):4149-53. PMID: 1570341.
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    132. Weiner RI, Wetsel W, Goldsmith P, Martinez de la Escalera G, Windle J, Padula C, Choi A, Negro-Vilar A, Mellon P. Gonadotropin-releasing hormone neuronal cell lines. Front Neuroendocrinol. 1992 Apr; 13(2):95-119. PMID: 1468602.
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    133. Mellon PL, Wetsel WC, Windle JJ, Valença MM, Goldsmith PC, Whyte DB, Eraly SA, Negro-Vilar A, Weiner RI. Immortalized hypothalamic gonadotropin-releasing hormone neurons. Ciba Found Symp. 1992; 168:104-17; discussion 117-26. PMID: 1330456.
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    134. González-Manchón C, Bilezikjian LM, Corrigan AZ, Mellon PL, Vale W. Activin-A modulates gonadotropin-releasing hormone secretion from a gonadotropin-releasing hormone-secreting neuronal cell line. Neuroendocrinology. 1991 Oct; 54(4):373-7. PMID: 1758579.
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    135. Liposits Z, Merchenthaler I, Wetsel WC, Reid JJ, Mellon PL, Weiner RI, Negro-Vilar A. Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone. Endocrinology. 1991 Sep; 129(3):1575-83. PMID: 1874189.
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    136. Wetsel WC, Mellon PL, Weiner RI, Negro-Vilar A. Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons. Endocrinology. 1991 Sep; 129(3):1584-95. PMID: 1714837.
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    137. Horn F, Bilezikjian LM, Perrin MH, Bosma MM, Windle JJ, Huber KS, Blount AL, Hille B, Vale W, Mellon PL. Intracellular responses to gonadotropin-releasing hormone in a clonal cell line of the gonadotrope lineage. Mol Endocrinol. 1991 Mar; 5(3):347-55. PMID: 1653891.
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    138. Steger DJ, Altschmied J, Büscher M, Mellon PL. Evolution of placenta-specific gene expression: comparison of the equine and human gonadotropin alpha-subunit genes. Mol Endocrinol. 1991 Feb; 5(2):243-55. PMID: 1710031.
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    139. Mellon PL, Windle JJ, Weiner RI. Immortalization of neuroendocrine cells by targeted oncogenesis. Recent Prog Horm Res. 1991; 47:69-93; discussion 93-6. PMID: 1745826.
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    140. Collins S, Altschmied J, Herbsman O, Caron MG, Mellon PL, Lefkowitz RJ. A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. J Biol Chem. 1990 Nov 05; 265(31):19330-5. PMID: 2172252.
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    141. O'Brien JM, Marcus DM, Bernards R, Carpenter JL, Windle JJ, Mellon P, Albert DM. A transgenic mouse model for trilateral retinoblastoma. Arch Ophthalmol. 1990 Aug; 108(8):1145-51. PMID: 1696469.
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    142. Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL, Weiner RI. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron. 1990 Jul; 5(1):1-10. PMID: 2196069.
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    143. Windle JJ, Weiner RI, Mellon PL. Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol Endocrinol. 1990 Apr; 4(4):597-603. PMID: 1704103.
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    144. Akerblom IE, Ridgway EC, Mellon PL. An alpha-subunit-secreting cell line derived from a mouse thyrotrope tumor. Mol Endocrinol. 1990 Apr; 4(4):589-96. PMID: 1704102.
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    145. Windle JJ, Albert DM, O'Brien JM, Marcus DM, Disteche CM, Bernards R, Mellon PL. Retinoblastoma in transgenic mice. Nature. 1990 Feb 15; 343(6259):665-9. PMID: 1689463.
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    146. Sealfon SC, Gillo B, Mundamattom S, Mellon PL, Windle JJ, Landau E, Roberts JL. Gonadotropin-releasing hormone receptor expression in Xenopus oocytes. Mol Endocrinol. 1990 Jan; 4(1):119-24. PMID: 2157973.
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    147. Correll LA, Woodford TA, Corbin JD, Mellon PL, McKnight GS. Functional characterization of cAMP-binding mutations in type I protein kinase. J Biol Chem. 1989 Oct 05; 264(28):16672-8. PMID: 2550452.
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    148. Mellon PL, Clegg CH, Correll LA, McKnight GS. Regulation of transcription by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):4887-91. PMID: 2544878.
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    149. O'Brien JM, Marcus DM, Niffenegger AS, Bernards R, Carpenter JL, Windle JJ, Mellon P, Albert DM. Trilateral retinoblastoma in transgenic mice. Trans Am Ophthalmol Soc. 1989; 87:301-22; discussion 322-6. PMID: 2576479.
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    150. Sassone-Corsi P, Visvader J, Ferland L, Mellon PL, Verma IM. Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element. Genes Dev. 1988 Dec; 2(12A):1529-38. PMID: 2850967.
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    151. Akerblom IE, Slater EP, Beato M, Baxter JD, Mellon PL. Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer. Science. 1988 Jul 15; 241(4863):350-3. PMID: 2838908.
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    152. Delegeane AM, Ferland LH, Mellon PL. Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements. Mol Cell Biol. 1987 Nov; 7(11):3994-4002. PMID: 2828923.
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    153. Isaacs RE, Findell PR, Mellon P, Wilson CB, Baxter JD. Hormonal regulation of expression of the endogenous and transfected human growth hormone gene. Mol Endocrinol. 1987 Aug; 1(8):569-76. PMID: 3153479.
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    154. Murray SS, Deaven LL, Burton DW, O'Connor DI, Mellon PL, Deftos LJ. The gene for human chromogranin A (CgA) is located on chromosome 14. Biochem Biophys Res Commun. 1987 Jan 15; 142(1):141-6. PMID: 3814131.
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    155. Cattini PA, Anderson TR, Baxter JD, Mellon P, Eberhardt NL. The human growth hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary tumor cells. J Biol Chem. 1986 Oct 05; 261(28):13367-72. PMID: 2428817.
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    156. Deftos LJ, Murray SS, Burton DW, Parmer RJ, O'Connor DT, Delegeane AM, Mellon PL. A cloned chromogranin A (CgA) cDNA detects a 2.3Kb mRNA in diverse neuroendocrine tissues. Biochem Biophys Res Commun. 1986 May 29; 137(1):418-23. PMID: 3718511.
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    157. Charnay P, Mellon P, Maniatis T. Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells. Mol Cell Biol. 1985 Jun; 5(6):1498-511. PMID: 3861935.
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    158. Slater EP, Anderson TR, Cattini PA, Eberhardt NL, Karin M, Mellon PL, Baxter JD. Tissue-specific influences affect glucocorticoid regulatory element actions on the human growth hormone gene promotor. Trans Assoc Am Physicians. 1985; 98:66-73. PMID: 3842208.
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    159. Charnay P, Treisman R, Mellon P, Chao M, Axel R, Maniatis T. Human alpha- and beta-globin gene transcription in mouse erythroleukaemia cells. Philos Trans R Soc Lond B Biol Sci. 1984 Dec 04; 307(1132):261-70. PMID: 6151696.
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    160. Charnay P, Treisman R, Mellon P, Chao M, Axel R, Maniatis T. Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell. 1984 Aug; 38(1):251-63. PMID: 6205764.
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    161. Chao MV, Mellon P, Charnay P, Maniatis T, Axel R. The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell. 1983 Feb; 32(2):483-93. PMID: 6572107.
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    162. Mellon P, Charnay P, Chao M, Axel R, Maniatis T. Regulated expression of cloned globin genes introduced into mouse erythroleukemia cells. Prog Clin Biol Res. 1983; 134:3-12. PMID: 6582520.
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    163. Chao MV, Mellon P, Charnay P, Maniatis T, Axel R. Introduction and expression of beta-globin genes in murine erythroleukemic cells. Gene Amplif Anal. 1983; 3:215-31. PMID: 6101028.
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    164. Zinn K, Mellon P, Ptashne M, Maniatis T. Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells. Proc Natl Acad Sci U S A. 1982 Aug; 79(16):4897-901. PMID: 6956899.
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    165. Mellon P, Parker V, Gluzman Y, Maniatis T. Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell. 1981 Dec; 27(2 Pt 1):279-88. PMID: 6277501.
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    166. Mellon P, Duesberg PH. Subgenomic, cellular Rous sarcoma virus RNAs contain oligonucleotides from the 3' half and the 5' terminus of virion RNA. Nature. 1977 Dec 15; 270(5638):631-4. PMID: 201866.
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    167. Wang L, Galehouse D, Mellon P, Duesberg P, Mason WS, Vogt PK. Mapping oligonucleotides of Rous sarcoma virus RNA that segregate with polymerase and group-specific antigen markers in recombinants. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):3952-6. PMID: 186781.
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