Pamela Mellon

Title(s)Recall Hcomp, Ob/Gyn & Reproductive sciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Other Positions
    Title(s)Professor of Neurosciences

    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, Berkeley, CaliforniaPhD06/1979Molecular Biology
    California Institute of Technology, Pasadena, CaliforniaPostdoctoral12/1980Biology
    Harvard University, Cambridge, MassachusettsPostdoctoral08/1984Biochemistry and Molecular Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Neurosecretory Gene Expression in the Hypothalamus
    NIH R01HD100580Aug 15, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Neuroendocrine Actions of Androgens in Female Reproduction
    NIH R01HD082567Apr 1, 2015 - Jan 31, 2021
    Role: Principal Investigator
    Endocrine and Growth Factor Regulation in the Pituitary
    NIH R01DK068121Mar 1, 2005 - Mar 31, 2005
    Role: Principal Investigator
    Diabetes Research Center (DRC)
    NIH P30DK063491Dec 1, 2002 - Jun 30, 2025
    Role: Co-Investigator
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NIH R13DK050196Jul 28, 1995 - Jul 27, 1996
    Role: Principal Investigator
    NIH U09RG000146Jul 1, 1994 - Sep 29, 2006
    Role: Principal Investigator
    Neurosecretory Gene Expression in the Hypothalamus
    NIH R01HD072754Jan 1, 1992 - Jun 30, 2018
    Role: Principal Investigator
    NIH R37HD020377Jan 1, 1992 - Jul 31, 2006
    Role: Principal Investigator
    Neurosecretory Gene Expression in the Hypothalamus
    NIH R01DK044838Jul 1, 1991 - Aug 31, 2012
    Role: Principal Investigator
    NIH R01HD023818Feb 1, 1988 - Jul 31, 1993
    Role: Principal Investigator
    NIH R03DK039798Sep 1, 1987 - Aug 31, 1988
    Role: Principal Investigator
    Molecular Mechanisms of Gonadotrope Differentiation
    NIH R01HD020377Jul 1, 1985 - Jun 30, 2012
    Role: Principal Investigator
    Training in Reproductive Sciences
    NIH T32HD007203Jul 1, 1979 - Apr 30, 2023
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH P50HD012303Dec 1, 1978 - Mar 31, 2021
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH U54HD012303Dec 1, 1978 - Jul 31, 2016
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specific manner in mice. Front Endocrinol (Lausanne). 2023; 14:1269672. Van Loh BM, Yaw AM, Breuer JA, Jackson B, Nguyen D, Jang K, Ramos F, Ho EV, Cui LJ, Gillette DLM, Sempere LF, Gorman MR, Tonsfeldt KJ, Mellon PL, Hoffmann HM. PMID: 38205198; PMCID: PMC10777845.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms. JCI Insight. 2023 02 08; 8(3). Cassin J, Stamou MI, Keefe KW, Sung KE, Bojo CC, Tonsfeldt KJ, Rojas RA, Ferreira Lopes V, Plummer L, Salnikov KB, Keefe DL, Ozata M, Genel M, Georgopoulos NA, Hall JE, Crowley WF, Seminara SB, Mellon PL, Balasubramanian R. PMID: 36602867; PMCID: PMC9977424.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Female fertility does not require Bmal1 in suprachiasmatic nucleus neurons expressing arginine vasopressin, vasoactive intestinal peptide, or neuromedin-S. Front Endocrinol (Lausanne). 2022; 13:956169. Tonsfeldt KJ, Cui LJ, Lee J, Walbeek TJ, Brusman LE, Jin Y, Mieda M, Gorman MR, Mellon PL. PMID: 35992114; PMCID: PMC9389073.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice. Mol Cell Endocrinol. 2022 04 15; 546:111577. Lavalle SN, Chou T, Hernandez J, Naing NCP, He MY, Tonsfeldt KJ, Mellon PL. PMID: 35121076; PMCID: PMC8934285.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge. Endocrinology. 2022 02 01; 163(2). Tonsfeldt KJ, Mellon PL, Hoffmann HM. PMID: 34967900; PMCID: PMC8782605.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice. Mol Metab. 2022 03; 57:101431. Meadows JD, Breuer JA, Lavalle SN, Hirschenberger MR, Patel MM, Nguyen D, Kim A, Cassin J, Gorman MR, Welsh DK, Mellon PL, Hoffmann HM. PMID: 34974160; PMCID: PMC8810556.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells. Endocrinology. 2021 12 01; 162(12). Ho EV, Shi C, Cassin J, He MY, Nguyen RD, Ryan GE, Tonsfeldt KJ, Mellon PL. PMID: 34529765; PMCID: PMC8507963.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    8. The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res. 2021 10; 99(10):2625-2645. Hoffmann HM, Meadows JD, Breuer JA, Yaw AM, Nguyen D, Tonsfeldt KJ, Chin AY, Devries BM, Trang C, Oosterhouse HJ, Lee JS, Doser JW, Gorman MR, Welsh DK, Mellon PL. PMID: 34212416; PMCID: PMC8577618.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    9. Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB. Endocrinology. 2021 07 01; 162(7). Bohaczuk SC, Cassin J, Slaiwa TI, Thackray VG, Mellon PL. PMID: 33824966; PMCID: PMC8157479.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1. Mol Cell Endocrinol. 2021 08 20; 534:111358. Lavalle SN, Chou T, Hernandez J, Naing NCP, Tonsfeldt KJ, Hoffmann HM, Mellon PL. PMID: 34098016; PMCID: PMC8319105.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes. Mol Cell Endocrinol. 2021 06 15; 530:111286. Ryan GE, Bohaczuk SC, Cassin J, Witham EA, Shojaei S, Ho EV, Thackray VG, Mellon PL. PMID: 33872733; PMCID: PMC8177864.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1. Endocrinology. 2021 04 01; 162(4). Schoeller EL, Tonsfeldt KJ, Sinkovich M, Shi R, Mellon PL. PMID: 33539533; PMCID: PMC7901660.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    13. FSHB  Transcription is Regulated by a Novel 5' Distal Enhancer With a Fertility-Associated Single Nucleotide Polymorphism. Endocrinology. 2021 01 01; 162(1). Bohaczuk SC, Thackray VG, Shen J, Skowronska-Krawczyk D, Mellon PL. PMID: 33009549; PMCID: PMC7846141.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    14. Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6. Elife. 2020 08 07; 9. Coré N, Erni A, Hoffmann HM, Mellon PL, Saurin AJ, Beclin C, Cremer H. PMID: 32762844; PMCID: PMC7440913.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep. 2020 08 03; 10(1):13063. Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman AS, Mellon PL, Lawson MA. PMID: 32747664; PMCID: PMC7400764.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. Cell. 2020 03 19; 180(6):1212-1227.e14. Gou LT, Lim DH, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu MF, Fu XD. PMID: 32169215; PMCID: PMC7190278.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    17. The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function. Mol Neurobiol. 2020 Feb; 57(2):1217-1232. Pandolfi EC, Breuer JA, Nguyen Huu VA, Talluri T, Nguyen D, Lee JS, Hu R, Bharti K, Skowronska-Krawczyk D, Gorman MR, Mellon PL, Hoffmann HM. PMID: 31705443; PMCID: PMC7035166.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    18. Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility. Endocrinology. 2019 09 01; 160(9):2151-2164. Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL. PMID: 31211355; PMCID: PMC6821215.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    19. Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines. J Endocr Soc. 2019 May 01; 3(5):902-920. Ruf-Zamojski F, Ge Y, Pincas H, Shan J, Song Y, Hines N, Kelley K, Montagna C, Nair P, Toufaily C, Bernard DJ, Mellon PL, Nair V, Turgeon JL, Sealfon SC. PMID: 31020055; PMCID: PMC6469952.
      View in: PubMed   Mentions: 10  
    20. The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc. 2019 Apr 01; 3(4):716-733. Tonsfeldt KJ, Schoeller EL, Brusman LE, Cui LJ, Lee J, Mellon PL. PMID: 30906911; PMCID: PMC6425515.
      View in: PubMed   Mentions: 16  
    21. Differential CRE Expression in Lhrh-cre and GnRH-cre Alleles and the Impact on Fertility in Otx2-Flox Mice. Neuroendocrinology. 2019; 108(4):328-342. Hoffmann HM, Larder R, Lee JS, Hu RJ, Trang C, Devries BM, Clark DD, Mellon PL. PMID: 30739114; PMCID: PMC6753941.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    22. Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2 Causes Subfertility in Mice via Distinct Mechanisms. Neuroendocrinology. 2019; 109(3):200-207. Hoffmann HM, Pandolfi EC, Larder R, Mellon PL. PMID: 30261489; PMCID: PMC6437011.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    23. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.
      View in: PubMed   Mentions: 4     Fields:    
    24. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409; PMCID: PMC6033669.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    25. Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. Endocrinology. 2018 04 01; 159(4):1734-1747. Ryan GE, Malik S, Mellon PL. PMID: 29471436; PMCID: PMC6097580.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    26. Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol. 2018 Nov; 55(11):8709-8727. Pandolfi EC, Hoffmann HM, Schoeller EL, Gorman MR, Mellon PL. PMID: 29589282; PMCID: PMC6156938.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    27. Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol. 2017 Oct 24; 15(1):86. Xie H, Hoffmann HM, Iyer AK, Brayman MJ, Ngo C, Sunshine MJ, Mellon PL. PMID: 29065928; PMCID: PMC5655979.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    28. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol. 2018 02 05; 461:143-154. Hoffmann HM, Gong P, Tamrazian A, Mellon PL. PMID: 28890143; PMCID: PMC5756504.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    29. Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology. 2016 Dec; 157(12):4914-4929. Schoeller EL, Clark DD, Dey S, Cao NV, Semaan SJ, Chao LW, Kauffman AS, Stowers L, Mellon PL. PMID: 27704948; PMCID: PMC5133342.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    30. A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. Neurosci Commun (Houst). 2016; 2. Hoffmann HM, Mellon PL. PMID: 28164172; PMCID: PMC5287408.
      View in: PubMed   Mentions: 7  
    31. A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. PLoS One. 2016; 11(7):e0158597. Huang PP, Brusman LE, Iyer AK, Webster NJ, Mellon PL. PMID: 27389022; PMCID: PMC4936741.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    32. Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci. 2016 Mar 23; 36(12):3506-18. Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC, Mellon PL. PMID: 27013679; PMCID: PMC4804008.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    33. P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Mol Cell. 2015 Sep 17; 59(6):931-40. Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zheng L, Krawczyk M, Chen D, Shi C, Zin C, Zhu J, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong S, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K. PMID: 26365380; PMCID: PMC4648709.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    34. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. PMID: 26203175; PMCID: PMC4710190.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    35. Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice. Endocrinology. 2015 Sep; 156(9):3091-7. Stephens SB, Tolson KP, Rouse ML, Poling MC, Hashimoto-Partyka MK, Mellon PL, Kauffman AS. PMID: 26076042; PMCID: PMC4541622.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    36. Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. Mol Endocrinol. 2015 Jun; 29(6):842-55. Xie H, Hoffmann HM, Meadows JD, Mayo SL, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon PL. PMID: 25915183; PMCID: PMC4447639.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    37. KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse. Endocrinology. 2014 Nov; 155(11):4433-46. Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon PL, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV. PMID: 25147978; PMCID: PMC4197989.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    38. Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Mol Endocrinol. 2014 Oct; 28(10):1640-55. Roybal LL, Hambarchyan A, Meadows JD, Barakat NH, Pepa PA, Breen KM, Mellon PL, Coss D. PMID: 25105693; PMCID: PMC4179627.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    39. Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology. 2014 Oct; 155(10):4043-53. Hoffmann HM, Tamrazian A, Xie H, Pérez-Millán MI, Kauffman AS, Mellon PL. PMID: 25060364; PMCID: PMC4164932.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    40. Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology. 2014 Oct; 155(10):3909-19. Glidewell-Kenney CA, Trang C, Shao PP, Gutierrez-Reed N, Uzo-Okereke AM, Coss D, Mellon PL. PMID: 25057795; PMCID: PMC4164922.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    41. Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):71-7. Breen KM, Mellon PL. PMID: 24012628; PMCID: PMC3942370.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol. 2013 Sep 05; 377(1-2):16-22. Larder R, Kimura I, Meadows J, Clark DD, Mayo S, Mellon PL. PMID: 23811236; PMCID: PMC3771655.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    43. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol. 2013 Aug; 27(8):1283-94. Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Coss D, Kauffman AS, Mellon PL. PMID: 23770611; PMCID: PMC3725344.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    44. Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol. 2013 Mar; 27(3):437-54. Glidewell-Kenney CA, Shao PP, Iyer AK, Grove AM, Meadows JD, Mellon PL. PMID: 23393128; PMCID: PMC3589675.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    45. Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J Biol Rhythms. 2013 Feb; 28(1):15-25. Clark DD, Gorman MR, Hatori M, Meadows JD, Panda S, Mellon PL. PMID: 23382588; PMCID: PMC3586279.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    46. Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol. 2013 Mar; 27(3):422-36. Xie H, Cherrington BD, Meadows JD, Witham EA, Mellon PL. PMID: 23371388; PMCID: PMC3589667.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    47. Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol Cell Endocrinol. 2012 Nov 05; 363(1-2):92-9. Brayman MJ, Pepa PA, Mellon PL. PMID: 22877652; PMCID: PMC3447085.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    48. Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells. Mol Endocrinol. 2012 Oct; 26(10):1716-31. Breen KM, Thackray VG, Hsu T, Mak-McCully RA, Coss D, Mellon PL. PMID: 22851703; PMCID: PMC3458227.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    49. Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 2012 Sep; 153(9):4522-32. Witham EA, Meadows JD, Shojaei S, Kauffman AS, Mellon PL. PMID: 22778229; PMCID: PMC3423623.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    50. FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter. Endocrinology. 2012 Apr; 153(4):2023-33. Ghochani Y, Saini JK, Mellon PL, Thackray VG. PMID: 22294749; PMCID: PMC3320250.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    51. Androgen receptor repression of GnRH gene transcription. Mol Endocrinol. 2012 Jan; 26(1):2-13. Brayman MJ, Pepa PA, Berdy SE, Mellon PL. PMID: 22074952; PMCID: PMC3248321.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    52. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells. Reprod Toxicol. 2011 Jul; 32(1):85-92. Lan D, Lu M, Sharma S, Mellon PL, Olefsky JM, Webster NJ. PMID: 21679764; PMCID: PMC3155991.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    53. Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2011 Jul; 165(1):145-50. Beneduzzi D, Iyer AK, Trarbach EB, Silveira-Neto AP, Silveira LG, Tusset C, Yip K, Mendonça BB, Mellon PL, Latronico AC. PMID: 21543378; PMCID: PMC3203643.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    54. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol. 2011 Jun; 79(6):1053-60. Yueh MF, Mellon PL, Tukey RH. PMID: 21415305; PMCID: PMC3102552.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    55. GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. Mol Endocrinol. 2011 Apr; 25(4):669-80. Ely HA, Mellon PL, Coss D. PMID: 21292826; PMCID: PMC3063085.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    56. Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction. Mol Endocrinol. 2011 Mar; 25(3):460-73. Iyer AK, Brayman MJ, Mellon PL. PMID: 21239613; PMCID: PMC3045737.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    57. Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J Neurosci. 2011 Jan 12; 31(2):426-38. Larder R, Clark DD, Miller NL, Mellon PL. PMID: 21228153; PMCID: PMC3103738.
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    58. PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod. 2011 Mar; 84(3):466-75. Sharma S, Sharma PM, Mistry DS, Chang RJ, Olefsky JM, Mellon PL, Webster NJ. PMID: 21076077; PMCID: PMC3043129.
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    59. Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression. Mol Endocrinol. 2010 Oct; 24(10):1949-64. Iyer AK, Miller NL, Yip K, Tran BH, Mellon PL. PMID: 20667983; PMCID: PMC2954641.
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    60. A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab. 2010 Sep; 21(9):562-8. Coss D, Mellon PL, Thackray VG. PMID: 20598900; PMCID: PMC2933269.
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    61. Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology. 2010 Jun; 151(6):2669-80. Breen KM, Thackray VG, Coss D, Mellon PL. PMID: 20357224; PMCID: PMC2875819.
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    62. FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes. Mol Endocrinol. 2010 May; 24(5):1037-51. Corpuz PS, Lindaman LL, Mellon PL, Coss D. PMID: 20233786; PMCID: PMC2870942.
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    63. Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol. 2010 Jan 27; 314(2):192-203. Thackray VG, Mellon PL, Coss D. PMID: 19747958; PMCID: PMC2815122.
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    64. Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem. 2009 Jun 19; 284(25):16966-16978. Larder R, Mellon PL. PMID: 19401468; PMCID: PMC2719334.
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    65. Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology. 2009 May; 150(5):2395-403. Thackray VG, Hunnicutt JL, Memon AK, Ghochani Y, Mellon PL. PMID: 19106225; PMCID: PMC2671912.
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    66. Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development. Hum Mol Genet. 2009 Jan 15; 18(2):248-60. Miller NL, Wevrick R, Mellon PL. PMID: 18930956; PMCID: PMC2638776.
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    67. Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes. Mol Cell Endocrinol. 2009 Jan 27; 298(1-2):57-65. Avelino-Cruz JE, Flores A, Cebada J, Mellon PL, Felix R, Monjaraz E. PMID: 18834922; PMCID: PMC2659688.
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    68. NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. Mol Cell Endocrinol. 2008 Nov 25; 295(1-2):106-14. Cherrington BD, Bailey JS, Diaz AL, Mellon PL. PMID: 18760324; PMCID: PMC2640340.
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    69. Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology. 2008 Jul; 149(7):3643-55. Sasson R, Luu SH, Thackray VG, Mellon PL. PMID: 18403486; PMCID: PMC2453092.
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    70. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology. 2008 Jun; 149(6):2807-15. McMahon HE, Hashimoto O, Mellon PL, Shimasaki S. PMID: 18308851; PMCID: PMC2408818.
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    71. Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology. 2008 Mar; 149(3):1091-102. Thackray VG, Mellon PL. PMID: 18079204; PMCID: PMC2275352.
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    72. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. Lu M, Tang Q, Olefsky JM, Mellon PL, Webster NJ. PMID: 18006641; PMCID: PMC2262174.
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    73. Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17447-52. Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L, Jacobson-Dickman EE, Mellon PL, Zhou QY, Crowley WF. PMID: 17959774; PMCID: PMC2077276.
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    74. p38 mitogen-activated protein kinase is critical for synergistic induction of the FSH(beta) gene by gonadotropin-releasing hormone and activin through augmentation of c-Fos induction and Smad phosphorylation. Mol Endocrinol. 2007 Dec; 21(12):3071-86. Coss D, Hand CM, Yaphockun KK, Ely HA, Mellon PL. PMID: 17823303; PMCID: PMC2932484.
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    75. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. PMID: 17299135; PMCID: PMC2932486.
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    76. Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons. Neuroendocrinology. 2006; 84(6):353-63. Sasson R, Dearth RK, White RS, Chappell PE, Mellon PL. PMID: 17192702; PMCID: PMC2941430.
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    77. Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology. 2007 Feb; 148(2):762-73. McGillivray SM, Thackray VG, Coss D, Mellon PL. PMID: 17082263; PMCID: PMC2932480.
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    78. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ. PMID: 16772531; PMCID: PMC2673912.
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    79. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol. 2006 Sep; 20(9):2062-79. Thackray VG, McGillivray SM, Mellon PL. PMID: 16675544; PMCID: PMC2941439.
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    80. The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem. 2005 Sep 02; 280(35):30975-83. Rave-Harel N, Miller NL, Givens ML, Mellon PL. PMID: 16002402; PMCID: PMC2773698.
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    81. The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells. Mol Endocrinol. 2005 Nov; 19(11):2769-79. Tang Q, Mazur M, Mellon PL. PMID: 15994198; PMCID: PMC2935804.
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    82. Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol. 2005 Oct; 19(10):2610-23. Coss D, Thackray VG, Deng CX, Mellon PL. PMID: 15961509; PMCID: PMC2932483.
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    83. Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem. 2005 May 13; 280(19):19156-65. Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein JL, Robert B, Mellon PL. PMID: 15743757; PMCID: PMC2932481.
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    84. Mouse GnRH receptor gene expression is mediated by the LHX3 homeodomain protein. Endocrinology. 2005 May; 146(5):2180-5. McGillivray SM, Bailey JS, Ramezani R, Kirkwood BJ, Mellon PL. PMID: 15705775; PMCID: PMC2930620.
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    85. Phylogenetic footprinting reveals evolutionarily conserved regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression. Mol Endocrinol. 2004 Dec; 18(12):2950-66. Givens ML, Kurotani R, Rave-Harel N, Miller NL, Mellon PL. PMID: 15319450; PMCID: PMC2932476.
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    86. TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1. J Biol Chem. 2004 Jul 16; 279(29):30287-97. Rave-Harel N, Givens ML, Nelson SB, Duong HA, Coss D, Clark ME, Hall SB, Kamps MP, Mellon PL. PMID: 15138251; PMCID: PMC2935805.
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    87. Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol. 2004 May; 18(5):1158-70. Bailey JS, Rave-Harel N, McGillivray SM, Coss D, Mellon PL. PMID: 14764653; PMCID: PMC2935796.
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    88. Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol. 2004 Apr; 18(4):925-40. Spady TJ, Shayya R, Thackray VG, Ehrensberger L, Bailey JS, Mellon PL. PMID: 14701939; PMCID: PMC2932479.
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    89. Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci. 2003 Dec 03; 23(35):11202-13. Chappell PE, White RS, Mellon PL. PMID: 14657179; PMCID: PMC2932475.
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    90. A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone. J Biol Chem. 2004 Jan 02; 279(1):152-62. Coss D, Jacobs SB, Bender CE, Mellon PL. PMID: 14570911; PMCID: PMC2930619.
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    91. Pituitary tumorigenesis targeted by the ovine follicle-stimulating hormone beta-subunit gene regulatory region in transgenic mice. Mol Cell Endocrinol. 2003 May 30; 203(1-2):169-83. Pernasetti F, Spady TJ, Hall SB, Rosenberg SB, Givens ML, Anderson S, Paulus M, Miller WL, Mellon PL. PMID: 12782413.
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    92. Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene. Mol Endocrinol. 2003 Aug; 17(8):1470-83. Jacobs SB, Coss D, McGillivray SM, Mellon PL. PMID: 12730328; PMCID: PMC2933173.
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    93. Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements. Mol Endocrinol. 2002 Nov; 16(11):2413-25. Kelley CG, Givens ML, Rave-Harel N, Nelson SB, Anderson S, Mellon PL. PMID: 12403831; PMCID: PMC2930614.
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    94. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. PMID: 12193554; PMCID: PMC2932485.
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    95. A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty. Clin Endocrinol (Oxf). 2002 Aug; 57(2):283-91. Arroyo A, Pernasetti F, Vasilyev VV, Amato P, Yen SS, Mellon PL. PMID: 12153609; PMCID: PMC2932477.
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    96. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 12050161; PMCID: PMC2930616.
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    97. An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation. Mol Endocrinol. 2002 Jun; 16(6):1280-98. Rosenberg SB, Mellon PL. PMID: 12040015; PMCID: PMC2932471.
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    98. Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways. Endocrinology. 2002 May; 143(5):1651-9. Vasilyev VV, Pernasetti F, Rosenberg SB, Barsoum MJ, Austin DA, Webster NJ, Mellon PL. PMID: 11956146; PMCID: PMC2930615.
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    99. Complementary expression of IGF-II and IGFBP-5 during anterior pituitary development. Dev Biol. 2002 Apr 15; 244(2):319-28. Holley SJ, Hall SB, Mellon PL. PMID: 11944940.
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    100. Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology. 2002 Apr; 143(4):1404-12. Lawson MA, Macconell LA, Kim J, Powl BT, Nelson SB, Mellon PL. PMID: 11897697.
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    101. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause. 2002 Mar-Apr; 9(2):145-50. Amato P, Christophe S, Mellon PL. PMID: 11875334.
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    102. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. Liu F, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 11875099.
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    103. Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model. Endocrinology. 2001 Jun; 142(6):2284-95. Pernasetti F, Vasilyev VV, Rosenberg SB, Bailey JS, Huang HJ, Miller WL, Mellon PL. PMID: 11356674.
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    104. Submandibular gland adenocarcinoma of intercalated duct origin in Smgb-Tag mice. Lab Invest. 2000 Nov; 80(11):1657-70. Dardick I, Ho J, Paulus M, Mellon PL, Mirels L. PMID: 11092526.
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    105. Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. Mol Endocrinol. 2000 Nov; 14(11):1811-9. Sosnowski R, Mellon PL, Lawson MA. PMID: 11075814.
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    106. Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol. 2000 Sep; 14(9):1509-22. Nelson SB, Lawson MA, Kelley CG, Mellon PL. PMID: 10976927.
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    107. The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter. Mol Endocrinol. 2000 Aug; 14(8):1246-56. Kelley CG, Lavorgna G, Clark ME, Boncinelli E, Mellon PL. PMID: 10935548.
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    108. AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin. Nucleic Acids Res. 2000 Feb 15; 28(4):1036-43. LiCalsi C, Christophe S, Steger DJ, Buescher M, Fischer W, Mellon PL. PMID: 10648798; PMCID: PMC102581.
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    109. Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/cyclic-guanosine 5'-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression. Mol Endocrinol. 2000 Feb; 14(2):212-28. Belsham DD, Mellon PL. PMID: 10674395.
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    110. Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene. J Clin Endocrinol Metab. 2000 Jan; 85(1):390-7. Pernasetti F, Toledo SP, Vasilyev VV, Hayashida CY, Cogan JD, Ferrari C, Lourenço DM, Mellon PL. PMID: 10634415.
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    111. The insulin-like growth factor system in the GT1-7 GnRH neuronal cell line. Neuroendocrinology. 1999 Nov; 70(5):353-9. Anderson RA, Zwain IH, Arroyo A, Mellon PL, Yen SS. PMID: 10567861.
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    112. Activin A regulation of gonadotropin-releasing hormone synthesis and release in vitro. Neuroendocrinology. 1999 Oct; 70(4):246-54. MacConell LA, Lawson MA, Mellon PL, Roberts VJ. PMID: 10529619.
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    113. Expression of Ptx1 in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells. Cell Tissue Res. 1999 Oct; 298(1):55-61. Kurotani R, Tahara S, Sanno N, Teramoto A, Mellon PL, Inoue K, Yoshimura S, Osamura RY. PMID: 10555539; PMCID: PMC6095709.
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    114. Expression of ptx1 in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells Cell Tissue Res. 1999 Oct; 298(1):55-61. Kurotani R, Tahara S, Sanno N, Teramoto A, Mellon PL, Inoue K, Yoshimura S, Osamura RY. PMID: 10502117.
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    116. Discrete stages of anterior pituitary differentiation recapitulated in immortalized cell lines. Mol Cell Endocrinol. 1998 May 25; 140(1-2):25-30. Alarid ET, Holley S, Hayakawa M, Mellon PL. PMID: 9722164.
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    117. The GnRH promoter: target of transcription factors, hormones, and signaling pathways. Mol Cell Endocrinol. 1998 May 25; 140(1-2):151-5. Nelson SB, Eraly SA, Mellon PL. PMID: 9722183.
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    118. Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse. Mol Cell Endocrinol. 1998 May 25; 140(1-2):157-61. Lawson MA, Mellon PL. PMID: 9722184.
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    119. The basic helix-loop-helix, leucine zipper transcription factor, USF (upstream stimulatory factor), is a key regulator of SF-1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells. Mol Endocrinol. 1998 May; 12(5):714-26. Harris AN, Mellon PL. PMID: 9605934.
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    120. Oct-1 binds promoter elements required for transcription of the GnRH gene. Mol Endocrinol. 1998 Apr; 12(4):469-81. Eraly SA, Nelson SB, Huang KM, Mellon PL. PMID: 9544983.
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    121. Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol. 1998 Mar; 12(3):364-77. Lawson MA, Buhain AR, Jovenal JC, Mellon PL. PMID: 9514154.
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    122. Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development. 1996 Oct; 122(10):3319-29. Alarid ET, Windle JJ, Whyte DB, Mellon PL. PMID: 8898243.
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    123. The L beta T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion. Endocrinology. 1996 Jul; 137(7):2979-89. Thomas P, Mellon PL, Turgeon J, Waring DW. PMID: 8770922.
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    124. GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol Cell Biol. 1996 Jul; 16(7):3596-605. Lawson MA, Whyte DB, Mellon PL. PMID: 8668176; PMCID: PMC231355.
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    125. Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Mol Endocrinol. 1996 Apr; 10(4):439-50. Turgeon JL, Kimura Y, Waring DW, Mellon PL. PMID: 8721988.
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    126. NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. EMBO J. 1996 Feb 01; 15(3):538-47. Belsham DD, Wetsel WC, Mellon PL. PMID: 8599937; PMCID: PMC449972.
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    127. The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol Cell Biol. 1995 Nov; 15(11):6169-77. Clark ME, Mellon PL. PMID: 7565769; PMCID: PMC230868.
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    128. Mechanism of action of gonadotropin-releasing hormone upon gonadotropin alpha-subunit mRNA levels in the alpha T3-1 cell line: role of Ca2+ and protein kinase C. Biochem J. 1995 Jul 01; 309 ( Pt 1):325-9. Ben-Menahem D, Shraga-Levine Z, Mellon PL, Naor Z. PMID: 7542447; PMCID: PMC1135837.
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    129. Regulation of gonadotropin-releasing hormone transcription by protein kinase C is mediated by evolutionarily conserved promoter-proximal elements. Mol Endocrinol. 1995 Jul; 9(7):848-59. Eraly SA, Mellon PL. PMID: 7476968.
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    130. Basic fibroblast growth factor: the neurotrophic factor influencing the ingrowth of neural tissue into the anterior pituitary of alpha-T7 transgenic mice? Neuroendocrinology. 1995 Jun; 61(6):622-7. Schechter J, Stauber C, Windle JJ, Mellon P. PMID: 7659188.
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    131. A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol Endocrinol. 1995 Apr; 9(4):467-77. Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP, Mellon PL. PMID: 7659090.
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    132. Down-regulation of the gonadotropin-releasing hormone receptor messenger ribonucleic acid by activation of adenylyl cyclase in alpha T3-1 pituitary gonadotrope cells. Endocrinology. 1995 Apr; 136(4):1361-6. Alarid ET, Mellon PL. PMID: 7895646.
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    133. Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog Horm Res. 1995; 50:459-63. Lawson MA, Whyte DB, Eraly SA, Mellon PL. PMID: 7740182.
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    134. GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland. Mol Cell Biol. 1994 Aug; 14(8):5592-602. Steger DJ, Hecht JH, Mellon PL. PMID: 7518566; PMCID: PMC359078.
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    135. The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone alpha-subunit gene in pituitary gonadotropes. Mol Endocrinol. 1994 Jul; 8(7):878-85. Barnhart KM, Mellon PL. PMID: 7527122.
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    136. The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16; 142(2):313-4. Barnhart KM, Mellon PL. PMID: 8194772.
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    137. Coordinate control of the alpha- and beta-subunit genes of human chorionic gonadotropin by trophoblast-specific element-binding protein. Mol Endocrinol. 1993 Dec; 7(12):1579-88. Steger DJ, Büscher M, Hecht JH, Mellon PL. PMID: 7511787.
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    138. Helix-loop-helix proteins are present and differentially expressed in different cell lines from the anterior pituitary. Mol Cell Endocrinol. 1993 Oct; 96(1-2):167-76. Jackson SM, Barnhart KM, Mellon PL, Gutierrez-Hartmann A, Hoeffler JP. PMID: 8276132.
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    139. Expression of a retinoblastoma transgene results in dwarf mice. Genes Dev. 1993 Sep; 7(9):1654-62. Bignon YJ, Chen Y, Chang CY, Riley DJ, Windle JJ, Mellon PL, Lee WH. PMID: 8370518.
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    140. Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons. Endocrinology. 1993 Jun; 132(6):2360-70. Wetsel WC, Eraly SA, Whyte DB, Mellon PL. PMID: 8504741.
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    141. GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice. Genes Dev. 1993 Apr; 7(4):683-93. Lew D, Brady H, Klausing K, Yaginuma K, Theill LE, Stauber C, Karin M, Mellon PL. PMID: 8096199.
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    142. Neural tissue within anterior pituitary tumors generated by oncogene expression in transgenic mice. Neuroendocrinology. 1992 Sep; 56(3):300-11. Schechter J, Windle JJ, Stauber C, Mellon PL. PMID: 1331836.
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    143. Gonadotropin-releasing hormone-induced calcium signaling in clonal pituitary gonadotrophs. Endocrinology. 1992 Aug; 131(2):925-32. Merelli F, Stojilkovic SS, Iida T, Krsmanovic LZ, Zheng L, Mellon PL, Catt KJ. PMID: 1379169.
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    144. Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol Endocrinol. 1992 Jul; 6(7):1163-9. Tsutsumi M, Zhou W, Millar RP, Mellon PL, Roberts JL, Flanagan CA, Dong K, Gillo B, Sealfon SC. PMID: 1324422.
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    145. Analysis of DNA sequences required for pituitary-specific expression of the glycoprotein hormone alpha-subunit gene. Mol Endocrinol. 1992 Jun; 6(6):893-903. Schoderbek WE, Kim KE, Ridgway EC, Mellon PL, Maurer RA. PMID: 1379672.
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    146. Mutual cross-interference between glucocorticoid receptor and CREB inhibits transactivation in placental cells. New Biol. 1992 May; 4(5):527-40. Stauber C, Altschmied J, Akerblom IE, Marron JL, Mellon PL. PMID: 1387550.
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    147. Tissue-specific gene expression in the pituitary: the glycoprotein hormone alpha-subunit gene is regulated by a gonadotrope-specific protein. Mol Cell Biol. 1992 May; 12(5):2143-53. Horn F, Windle JJ, Barnhart KM, Mellon PL. PMID: 1373809; PMCID: PMC364386.
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    148. Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons. Proc Natl Acad Sci U S A. 1992 May 01; 89(9):4149-53. Wetsel WC, Valença MM, Merchenthaler I, Liposits Z, López FJ, Weiner RI, Mellon PL, Negro-Vilar A. PMID: 1570341; PMCID: PMC525650.
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    149. Gonadotropin-releasing hormone neuronal cell lines. Front Neuroendocrinol. 1992 Apr; 13(2):95-119. Weiner RI, Wetsel W, Goldsmith P, Martinez de la Escalera G, Windle J, Padula C, Choi A, Negro-Vilar A, Mellon P. PMID: 1468602.
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    150. Immortalized hypothalamic gonadotropin-releasing hormone neurons. Ciba Found Symp. 1992; 168:104-17; discussion 117-26. Mellon PL, Wetsel WC, Windle JJ, Valença MM, Goldsmith PC, Whyte DB, Eraly SA, Negro-Vilar A, Weiner RI. PMID: 1330456.
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    151. Activin-A modulates gonadotropin-releasing hormone secretion from a gonadotropin-releasing hormone-secreting neuronal cell line. Neuroendocrinology. 1991 Oct; 54(4):373-7. González-Manchón C, Bilezikjian LM, Corrigan AZ, Mellon PL, Vale W. PMID: 1758579.
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    152. Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone. Endocrinology. 1991 Sep; 129(3):1575-83. Liposits Z, Merchenthaler I, Wetsel WC, Reid JJ, Mellon PL, Weiner RI, Negro-Vilar A. PMID: 1874189.
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    153. Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons. Endocrinology. 1991 Sep; 129(3):1584-95. Wetsel WC, Mellon PL, Weiner RI, Negro-Vilar A. PMID: 1714837.
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    154. Intracellular responses to gonadotropin-releasing hormone in a clonal cell line of the gonadotrope lineage. Mol Endocrinol. 1991 Mar; 5(3):347-55. Horn F, Bilezikjian LM, Perrin MH, Bosma MM, Windle JJ, Huber KS, Blount AL, Hille B, Vale W, Mellon PL. PMID: 1653891.
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    155. Evolution of placenta-specific gene expression: comparison of the equine and human gonadotropin alpha-subunit genes. Mol Endocrinol. 1991 Feb; 5(2):243-55. Steger DJ, Altschmied J, Büscher M, Mellon PL. PMID: 1710031.
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    156. Immortalization of neuroendocrine cells by targeted oncogenesis. Recent Prog Horm Res. 1991; 47:69-93; discussion 93-6. Mellon PL, Windle JJ, Weiner RI. PMID: 1745826.
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    157. A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. J Biol Chem. 1990 Nov 05; 265(31):19330-5. Collins S, Altschmied J, Herbsman O, Caron MG, Mellon PL, Lefkowitz RJ. PMID: 2172252.
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    158. A transgenic mouse model for trilateral retinoblastoma. Arch Ophthalmol. 1990 Aug; 108(8):1145-51. O'Brien JM, Marcus DM, Bernards R, Carpenter JL, Windle JJ, Mellon P, Albert DM. PMID: 1696469.
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    159. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron. 1990 Jul; 5(1):1-10. Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL, Weiner RI. PMID: 2196069.
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    160. Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol Endocrinol. 1990 Apr; 4(4):597-603. Windle JJ, Weiner RI, Mellon PL. PMID: 1704103.
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    161. An alpha-subunit-secreting cell line derived from a mouse thyrotrope tumor. Mol Endocrinol. 1990 Apr; 4(4):589-96. Akerblom IE, Ridgway EC, Mellon PL. PMID: 1704102.
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    162. Retinoblastoma in transgenic mice. Nature. 1990 Feb 15; 343(6259):665-9. Windle JJ, Albert DM, O'Brien JM, Marcus DM, Disteche CM, Bernards R, Mellon PL. PMID: 1689463.
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    163. Gonadotropin-releasing hormone receptor expression in Xenopus oocytes. Mol Endocrinol. 1990 Jan; 4(1):119-24. Sealfon SC, Gillo B, Mundamattom S, Mellon PL, Windle JJ, Landau E, Roberts JL. PMID: 2157973.
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    164. Functional characterization of cAMP-binding mutations in type I protein kinase. J Biol Chem. 1989 Oct 05; 264(28):16672-8. Correll LA, Woodford TA, Corbin JD, Mellon PL, McKnight GS. PMID: 2550452.
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    165. Regulation of transcription by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):4887-91. Mellon PL, Clegg CH, Correll LA, McKnight GS. PMID: 2544878; PMCID: PMC297520.
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    166. Trilateral retinoblastoma in transgenic mice. Trans Am Ophthalmol Soc. 1989; 87:301-22; discussion 322-6. O'Brien JM, Marcus DM, Niffenegger AS, Bernards R, Carpenter JL, Windle JJ, Mellon P, Albert DM. PMID: 2576479; PMCID: PMC1298548.
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    167. Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element. Genes Dev. 1988 Dec; 2(12A):1529-38. Sassone-Corsi P, Visvader J, Ferland L, Mellon PL, Verma IM. PMID: 2850967.
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    168. Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer. Science. 1988 Jul 15; 241(4863):350-3. Akerblom IE, Slater EP, Beato M, Baxter JD, Mellon PL. PMID: 2838908.
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    169. Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements. Mol Cell Biol. 1987 Nov; 7(11):3994-4002. Delegeane AM, Ferland LH, Mellon PL. PMID: 2828923; PMCID: PMC368068.
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    170. Hormonal regulation of expression of the endogenous and transfected human growth hormone gene. Mol Endocrinol. 1987 Aug; 1(8):569-76. Isaacs RE, Findell PR, Mellon P, Wilson CB, Baxter JD. PMID: 3153479.
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    171. The gene for human chromogranin A (CgA) is located on chromosome 14. Biochem Biophys Res Commun. 1987 Jan 15; 142(1):141-6. Murray SS, Deaven LL, Burton DW, O'Connor DI, Mellon PL, Deftos LJ. PMID: 3814131.
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    172. The human growth hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary tumor cells. J Biol Chem. 1986 Oct 05; 261(28):13367-72. Cattini PA, Anderson TR, Baxter JD, Mellon P, Eberhardt NL. PMID: 2428817.
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    173. A cloned chromogranin A (CgA) cDNA detects a 2.3Kb mRNA in diverse neuroendocrine tissues. Biochem Biophys Res Commun. 1986 May 29; 137(1):418-23. Deftos LJ, Murray SS, Burton DW, Parmer RJ, O'Connor DT, Delegeane AM, Mellon PL. PMID: 3718511.
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    174. Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells. Mol Cell Biol. 1985 Jun; 5(6):1498-511. Charnay P, Mellon P, Maniatis T. PMID: 3861935; PMCID: PMC366883.
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    175. Tissue-specific influences affect glucocorticoid regulatory element actions on the human growth hormone gene promotor. Trans Assoc Am Physicians. 1985; 98:66-73. Slater EP, Anderson TR, Cattini PA, Eberhardt NL, Karin M, Mellon PL, Baxter JD. PMID: 3842208.
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    176. Human alpha- and beta-globin gene transcription in mouse erythroleukaemia cells. Philos Trans R Soc Lond B Biol Sci. 1984 Dec 04; 307(1132):261-70. Charnay P, Treisman R, Mellon P, Chao M, Axel R, Maniatis T. PMID: 6151696.
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    177. Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell. 1984 Aug; 38(1):251-63. Charnay P, Treisman R, Mellon P, Chao M, Axel R, Maniatis T. PMID: 6205764.
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    178. The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell. 1983 Feb; 32(2):483-93. Chao MV, Mellon P, Charnay P, Maniatis T, Axel R. PMID: 6572107.
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    179. Regulated expression of cloned globin genes introduced into mouse erythroleukemia cells. Prog Clin Biol Res. 1983; 134:3-12. Mellon P, Charnay P, Chao M, Axel R, Maniatis T. PMID: 6582520.
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    180. Introduction and expression of beta-globin genes in murine erythroleukemic cells. Gene Amplif Anal. 1983; 3:215-31. Chao MV, Mellon P, Charnay P, Maniatis T, Axel R. PMID: 6101028.
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    181. Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells. Proc Natl Acad Sci U S A. 1982 Aug; 79(16):4897-901. Zinn K, Mellon P, Ptashne M, Maniatis T. PMID: 6956899; PMCID: PMC346792.
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    182. Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell. 1981 Dec; 27(2 Pt 1):279-88. Mellon P, Parker V, Gluzman Y, Maniatis T. PMID: 6277501.
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    183. Subgenomic, cellular Rous sarcoma virus RNAs contain oligonucleotides from the 3' half and the 5' terminus of virion RNA. Nature. 1977 Dec 15; 270(5638):631-4. Mellon P, Duesberg PH. PMID: 201866.
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    184. Mapping oligonucleotides of Rous sarcoma virus RNA that segregate with polymerase and group-specific antigen markers in recombinants. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):3952-6. Wang L, Galehouse D, Mellon P, Duesberg P, Mason WS, Vogt PK. PMID: 186781; PMCID: PMC431279.
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