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Edward Holmes

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0602
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Cond. Acceptance Post-Bac. Prog. Scholarship Fund
    NIH/NIMHD S22MD000227Sep 30, 2002 - Sep 29, 2005
    Role: Co-Principal Investigator
    San Diego Regional IRB Enhancements
    NIH/NCRR S07RR018186Sep 1, 2002 - Aug 31, 2005
    Role: Principal Investigator
    RETROVIRAL ANTI-SENSE RNA--CELLULAR AND VIRAL RESPONSES
    NIH/NCI R01CA047631Jul 1, 1988 - Jun 30, 1993
    Role: Principal Investigator
    PHENOTYPE OF METABOLIC DISEASE CREATED BY VECTORS
    NIH/NIDDK R03DK039715Sep 1, 1987 - Aug 31, 1988
    Role: Principal Investigator
    ROLE OF THE DIENCEPHALON IN MEMORY
    NIH/NINDS R23NS020844Sep 1, 1983 - Aug 31, 1986
    Role: Principal Investigator
    PATHOBIOLOGY OF AMP DEAMINASE DEFICIENCY
    NIH/NIDDK R01DK012413May 1, 1979 - Apr 30, 2001
    Role: Principal Investigator
    PATHOGENISIS OF AMP DEAMINASE DEFICIENCY
    NIH/NIDDK R37DK012413May 1, 1979 - Apr 30, 1997
    Role: Principal Investigator
    PURINE METABOLISM:NUCLEOTIDE SYNTHESIS &INTERCONVERSION
    NIH/NIADDK R01AM012413May 1, 1979 - Apr 30, 1989
    Role: Principal Investigator
    GENERAL CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR000030Oct 1, 1975 - Mar 31, 2009
    Role: Co-Principal Investigator
    METABOLIC AND RHEUMATIC DISEASES
    NIH/NIADDK T32AM007015Jul 1, 1975 - Jun 30, 1986
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cheng J, Morisaki H, Toyama K, Sugimoto N, Shintani T, Tandelilin A, Hirase T, Holmes EW, Morisaki T. AMPD1: a novel therapeutic target for reversing insulin resistance. BMC Endocr Disord. 2014 Dec 15; 14:96. PMID: 25511531; PMCID: PMC4274759.
    2. Cheng J, Morisaki H, Sugimoto N, Dohi A, Shintani T, Kimura E, Toyama K, Ikawa M, Okabe M, Higuchi I, Matsuo S, Kawai Y, Hisatome I, Sugama T, Holmes EW, Morisaki T. Effect of isolated AMP deaminase deficiency on skeletal muscle function. Mol Genet Metab Rep. 2014; 1:51-59. PMID: 27896074.
      View in: PubMed
    3. Akizu N, Cantagrel V, Schroth J, Cai N, Vaux K, McCloskey D, Naviaux RK, Van Vleet J, Fenstermaker AG, Silhavy JL, Scheliga JS, Toyama K, Morisaki H, Sonmez FM, Celep F, Oraby A, Zaki MS, Al-Baradie R, Faqeih EA, Saleh MA, Spencer E, Rosti RO, Scott E, Nickerson E, Gabriel S, Morisaki T, Holmes EW, Gleeson JG. AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell. 2013 Aug 01; 154(3):505-17. PMID: 23911318; PMCID: PMC3815927.
    4. Brady LS, Giffin RB, Woodcock J, Cassell GH, Holmes EW. Grand challenges for psychiatric drug discovery: a perspective. Neuropsychopharmacology. 2008 Aug; 33(9):2047. PMID: 18626470.
      View in: PubMed
    5. Holmes EW. Of rice and men: Bill Kelley's next generation. J Clin Invest. 2005 Oct; 115(10):2948-52. PMID: 16200216; PMCID: PMC1240120.
    6. Goodarzi MO, Taylor KD, Guo X, QuiƱones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, Olefsky J, Rotter JI. Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005 Apr; 54(4):1222-7. PMID: 15793265.
      View in: PubMed
    7. Lavori PW, Krause-Steinrauf H, Brophy M, Buxbaum J, Cockroft J, Cox DR, Fiore L, Greely HT, Greenberg H, Holmes EW, Nelson LM, Sugarman J. Principles, organization, and operation of a DNA bank for clinical trials: a Department of Veterans Affairs cooperative study. Control Clin Trials. 2002 Jun; 23(3):222-39. PMID: 12057876.
      View in: PubMed