Edward Holmes

Title(s)	Emeritus Professor, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Cond. Acceptance Post-Bac. Prog. Scholarship Fund
NIH S22MD000227Sep 30, 2002 - Sep 29, 2005
Role: Co-Principal Investigator

San Diego Regional IRB Enhancements
NIH S07RR018186Sep 1, 2002 - Aug 31, 2005
Role: Principal Investigator

RETROVIRAL ANTI-SENSE RNA--CELLULAR AND VIRAL RESPONSES
NIH R01CA047631Jul 1, 1988 - Jun 30, 1993
Role: Principal Investigator

PHENOTYPE OF METABOLIC DISEASE CREATED BY VECTORS
NIH R03DK039715Sep 1, 1987 - Aug 31, 1988
Role: Principal Investigator

ROLE OF THE DIENCEPHALON IN MEMORY
NIH R23NS020844Sep 1, 1983 - Aug 31, 1986
Role: Principal Investigator

PATHOBIOLOGY OF AMP DEAMINASE DEFICIENCY
NIH R01DK012413May 1, 1979 - Apr 30, 2001
Role: Principal Investigator

PATHOGENISIS OF AMP DEAMINASE DEFICIENCY
NIH R37DK012413May 1, 1979 - Apr 30, 1997
Role: Principal Investigator

PURINE METABOLISM:NUCLEOTIDE SYNTHESIS &INTERCONVERSION
NIH R01AM012413May 1, 1979 - Apr 30, 1989
Role: Principal Investigator

GENERAL CLINICAL RESEARCH CENTER
NIH M01RR000030Oct 1, 1975 - Mar 31, 2009
Role: Co-Principal Investigator

METABOLIC AND RHEUMATIC DISEASES
NIH T32AM007015Jul 1, 1975 - Jun 30, 1986
Role: Principal Investigator

General Clinical Research Center
NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
Role: Co-Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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AMPD1: a novel therapeutic target for reversing insulin resistance. BMC Endocr Disord. 2014 Dec 15; 14:96. Cheng J, Morisaki H, Toyama K, Sugimoto N, Shintani T, Tandelilin A, Hirase T, Holmes EW, Morisaki T. PMID: 25511531; PMCID: PMC4274759.

View in: PubMed Mentions: 14 Fields:
End Endocrinology
Translation:Animals
Effect of isolated AMP deaminase deficiency on skeletal muscle function. Mol Genet Metab Rep. 2014; 1:51-59. Cheng J, Morisaki H, Sugimoto N, Dohi A, Shintani T, Kimura E, Toyama K, Ikawa M, Okabe M, Higuchi I, Matsuo S, Kawai Y, Hisatome I, Sugama T, Holmes EW, Morisaki T. PMID: 27896074; PMCID: PMC5121310.

View in: PubMed Mentions: 9
AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell. 2013 Aug 01; 154(3):505-17. Akizu N, Cantagrel V, Schroth J, Cai N, Vaux K, McCloskey D, Naviaux RK, Van Vleet J, Fenstermaker AG, Silhavy JL, Scheliga JS, Toyama K, Morisaki H, Sonmez FM, Celep F, Oraby A, Zaki MS, Al-Baradie R, Faqeih EA, Saleh MA, Spencer E, Rosti RO, Scott E, Nickerson E, Gabriel S, Morisaki T, Holmes EW, Gleeson JG. PMID: 23911318; PMCID: PMC3815927.

View in: PubMed Mentions: 50 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Grand challenges for psychiatric drug discovery: a perspective. Neuropsychopharmacology. 2008 Aug; 33(9):2047. Brady LS, Giffin RB, Woodcock J, Cassell GH, Holmes EW. PMID: 18626470; PMCID: PMC2917635.

View in: PubMed Mentions: 2 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Humans
Of rice and men: Bill Kelley's next generation. J Clin Invest. 2005 Oct; 115(10):2948-52. Holmes EW. PMID: 16200216; PMCID: PMC1240120.

View in: PubMed Mentions: Fields:
Med Medicine (General)
Translation:Humans Animals
Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005 Apr; 54(4):1222-7. Goodarzi MO, Taylor KD, Guo X, Quiñones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, Olefsky J, Rotter JI. PMID: 15793265.

View in: PubMed Mentions: 26 Fields:
End Endocrinology
Translation:Humans