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Nai-Wen Chi

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0673
La Jolla CA 92093
Phone858-534-6274
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of energy homeostasis and adiposity by a Golgi-associated PARP enzyme
    VA I01BX000702Oct 1, 2009 - Dec 31, 2013
    Role: Principal Investigator
    INSULIN-INDUCED TRANSLOCATION OF GLUCOSE TRANSPORTER
    NIH/NIDDK R03DK058616Sep 30, 2000 - Aug 31, 2003
    Role: Principal Investigator
    INSULIN-INDUCED TRANSLOCATION OF GLUCOSE TRANSPORTER
    NIH/NIDDK K08DK002540Sep 30, 1997 - Aug 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 05; 67(5):841-848. PMID: 29432123.
      View in: PubMed
    2. Wollam J, Mahata S, Riopel M, Hernandez-Carretero A, Biswas A, Bandyopadhyay GK, Chi NW, Eiden LE, Mahapatra NR, Corti A, Webster NJG, Mahata SK. Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion. Cell Tissue Res. 2017 06; 368(3):487-501. PMID: 28220294.
      View in: PubMed
    3. Tang K, Pasqua T, Biswas A, Mahata S, Tang J, Tang A, Bandyopadhyay GK, Sinha-Hikim AP, Chi NW, Webster NJ, Corti A, Mahata SK. Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol. 2017 Feb; 232(2):137-153. PMID: 27799464.
      View in: PubMed
    4. Woods GN, Saitman A, Gao H, Clarke NJ, Fitzgerald RL, Chi NW. A Young Woman With Recurrent Gestational Hypercalcemia and Acute Pancreatitis Caused by CYP24A1 Deficiency. J Bone Miner Res. 2016 Oct; 31(10):1841-1844. PMID: 27105398.
      View in: PubMed
    5. Yee B, Chi NW, Hansen LA, Lee RR, U HS, Savides TJ, Vinetz JM. Strongyloides stercoralis Hyperinfection Syndrome Presenting as Severe, Recurrent Gastrointestinal Bleeding, Leading to a Diagnosis of Cushing Disease. Am J Trop Med Hyg. 2015 Oct; 93(4):822-7. PMID: 26195463; PMCID: PMC4596606 [Available on 10/07/16].
    6. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. PMID: 25876076; PMCID: PMC4395342.
    7. Vu CU, Siddiqui JA, Wadensweiler P, Gayen JR, Avolio E, Bandyopadhyay GK, Biswas N, Chi NW, O'Connor DT, Mahata SK. Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. Endocrinology. 2014 Oct; 155(10):3793-805. PMID: 25051446.
      View in: PubMed
    8. Bandyopadhyay GK, Lu M, Avolio E, Siddiqui JA, Gayen JR, Wollam J, Vu CU, Chi NW, O'Connor DT, Mahata SK. Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance. Diabetes. 2015 Jan; 64(1):104-16. PMID: 25048197.
      View in: PubMed
    9. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. PMID: 24789228; PMCID: PMC4008632.
    10. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027; PMCID: PMC4025063.
    11. Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. PMID: 24531262; PMCID: PMC4077285.
    12. Bandyopadhyay GK, Vu CU, Gentile S, Lee H, Biswas N, Chi NW, O'Connor DT, Mahata SK. Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling. J Biol Chem. 2012 Jun 29; 287(27):23141-51. PMID: 22535963; PMCID: PMC3391131.
    13. Mosedale M, Egodage S, Calma RC, Chi NW, Chessler SD. Neurexin-1a contributes to insulin-containing secretory granule docking. J Biol Chem. 2012 Feb 24; 287(9):6350-61. PMID: 22235116; PMCID: PMC3307300.
    14. Yeh TY, Beiswenger KK, Li P, Bolin KE, Lee RM, Tsao TS, Murphy AN, Hevener AL, Chi NW. Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice. Diabetes. 2009 Nov; 58(11):2476-85. PMID: 19651815; PMCID: PMC2768175.
    15. Yeh TY, Sbodio JI, Tsun ZY, Luo B, Chi NW. Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase. Biochem J. 2007 Mar 01; 402(2):279-90. PMID: 17059388; PMCID: PMC1798437.
    16. Yeh TY, Meyer TN, Schwesinger C, Tsun ZY, Lee RM, Chi NW. Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly(ADP-ribosyl)ation. Biochem J. 2006 Nov 01; 399(3):415-25. PMID: 16884355; PMCID: PMC1615909.
    17. Yeh TY, Sbodio JI, Chi NW. Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3. Biochem Biophys Res Commun. 2006 Nov 24; 350(3):574-9. PMID: 17026964.
      View in: PubMed
    18. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky JM. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2005 Oct 21; 280(42):35361-71. PMID: 16085647.
      View in: PubMed
    19. Yeh TY, Sbodio JI, Nguyen MT, Meyer TN, Lee RM, Chi NW. Tankyrase-1 overexpression reduces genotoxin-induced cell death by inhibiting PARP1. Mol Cell Biochem. 2005 Aug; 276(1-2):183-92. PMID: 16132700.
      View in: PubMed
    20. Sbodio JI, Chi NW. Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. J Biol Chem. 2002 Aug 30; 277(35):31887-92. PMID: 12080061.
      View in: PubMed
    21. Sbodio JI, Lodish HF, Chi NW. Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J. 2002 Feb 01; 361(Pt 3):451-9. PMID: 11802774; PMCID: PMC1222327.