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Nai-Wen Chi

Title(s)Associate Professor, Medicine
SchoolHealth Sciences
Phone858-534-6274
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of energy homeostasis and adiposity by a Golgi-associated PARP enzyme
    VA I01BX000702Oct 1, 2009 - Dec 31, 2013
    Role: Principal Investigator
    INSULIN-INDUCED TRANSLOCATION OF GLUCOSE TRANSPORTER
    NIH/NIDDK R03DK058616Sep 30, 2000 - Aug 31, 2003
    Role: Principal Investigator
    INSULIN-INDUCED TRANSLOCATION OF GLUCOSE TRANSPORTER
    NIH/NIDDK K08DK002540Sep 30, 1997 - Aug 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 05; 67(5):841-848. PMID: 29432123.
      View in: PubMed
    2. Wollam J, Mahata S, Riopel M, Hernandez-Carretero A, Biswas A, Bandyopadhyay GK, Chi NW, Eiden LE, Mahapatra NR, Corti A, Webster NJG, Mahata SK. Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion. Cell Tissue Res. 2017 06; 368(3):487-501. PMID: 28220294.
      View in: PubMed
    3. Tang K, Pasqua T, Biswas A, Mahata S, Tang J, Tang A, Bandyopadhyay GK, Sinha-Hikim AP, Chi NW, Webster NJ, Corti A, Mahata SK. Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol. 2017 02; 232(2):137-153. PMID: 27799464.
      View in: PubMed
    4. Woods GN, Saitman A, Gao H, Clarke NJ, Fitzgerald RL, Chi NW. A Young Woman With Recurrent Gestational Hypercalcemia and Acute Pancreatitis Caused by CYP24A1 Deficiency. J Bone Miner Res. 2016 10; 31(10):1841-1844. PMID: 27105398.
      View in: PubMed
    5. Yee B, Chi NW, Hansen LA, Lee RR, U HS, Savides TJ, Vinetz JM. Strongyloides stercoralis Hyperinfection Syndrome Presenting as Severe, Recurrent Gastrointestinal Bleeding, Leading to a Diagnosis of Cushing Disease. Am J Trop Med Hyg. 2015 Oct; 93(4):822-7. PMID: 26195463; PMCID: PMC4596606 [Available on 10/07/16].
      View in: PubMed, PubMed Central
    6. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. PMID: 25876076; PMCID: PMC4395342.
      View in: PubMed, PubMed Central
    7. Vu CU, Siddiqui JA, Wadensweiler P, Gayen JR, Avolio E, Bandyopadhyay GK, Biswas N, Chi NW, O'Connor DT, Mahata SK. Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. Endocrinology. 2014 Oct; 155(10):3793-805. PMID: 25051446.
      View in: PubMed
    8. Bandyopadhyay GK, Lu M, Avolio E, Siddiqui JA, Gayen JR, Wollam J, Vu CU, Chi NW, O'Connor DT, Mahata SK. Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance. Diabetes. 2015 Jan; 64(1):104-16. PMID: 25048197.
      View in: PubMed
    9. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. PMID: 24789228; PMCID: PMC4008632.
      View in: PubMed, PubMed Central
    10. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027; PMCID: PMC4025063.
      View in: PubMed, PubMed Central
    11. Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. PMID: 24531262; PMCID: PMC4077285.
      View in: PubMed, PubMed Central
    12. Bandyopadhyay GK, Vu CU, Gentile S, Lee H, Biswas N, Chi NW, O'Connor DT, Mahata SK. Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling. J Biol Chem. 2012 Jun 29; 287(27):23141-51. PMID: 22535963; PMCID: PMC3391131.
      View in: PubMed, PubMed Central
    13. Mosedale M, Egodage S, Calma RC, Chi NW, Chessler SD. Neurexin-1a contributes to insulin-containing secretory granule docking. J Biol Chem. 2012 Feb 24; 287(9):6350-61. PMID: 22235116.
      View in: PubMed
    14. Yeh TY, Beiswenger KK, Li P, Bolin KE, Lee RM, Tsao TS, Murphy AN, Hevener AL, Chi NW. Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice. Diabetes. 2009 Nov; 58(11):2476-85. PMID: 19651815; PMCID: PMC2768175.
      View in: PubMed, PubMed Central
    15. Yeh TY, Sbodio JI, Tsun ZY, Luo B, Chi NW. Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase. Biochem J. 2007 Mar 01; 402(2):279-90. PMID: 17059388; PMCID: PMC1798437.
      View in: PubMed, PubMed Central
    16. Yeh TY, Meyer TN, Schwesinger C, Tsun ZY, Lee RM, Chi NW. Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly(ADP-ribosyl)ation. Biochem J. 2006 Nov 01; 399(3):415-25. PMID: 16884355; PMCID: PMC1615909.
      View in: PubMed, PubMed Central
    17. Yeh TY, Sbodio JI, Chi NW. Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3. Biochem Biophys Res Commun. 2006 Nov 24; 350(3):574-9. PMID: 17026964.
      View in: PubMed
    18. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky JM. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2005 Oct 21; 280(42):35361-71. PMID: 16085647.
      View in: PubMed
    19. Yeh TY, Sbodio JI, Nguyen MT, Meyer TN, Lee RM, Chi NW. Tankyrase-1 overexpression reduces genotoxin-induced cell death by inhibiting PARP1. Mol Cell Biochem. 2005 Aug; 276(1-2):183-92. PMID: 16132700.
      View in: PubMed
    20. Sbodio JI, Chi NW. Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. J Biol Chem. 2002 Aug 30; 277(35):31887-92. PMID: 12080061.
      View in: PubMed
    21. Sbodio JI, Lodish HF, Chi NW. Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J. 2002 Feb 01; 361(Pt 3):451-9. PMID: 11802774; PMCID: PMC1222327.
      View in: PubMed, PubMed Central
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