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Nai-wen Chi

Title(s)Associate Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    Regulation of energy homeostasis and adiposity by a Golgi-associated PARP enzyme
    VA I01BX000702Oct 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    INSULIN-INDUCED TRANSLOCATION OF GLUCOSE TRANSPORTER
    NIH/NIDDK R03DK058616Sep 30, 2000 - Oct 1, 2000
    Role: Principal Investigator
    INSULIN-INDUCED TRANSLOCATION OF GLUCOSE TRANSPORTER
    NIH/NIDDK K08DK002540Sep 30, 1997 - Aug 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Diabetes knowledge, risk and severity perceptions, lifestyle behaviours and management barriers among Sub-Saharan African immigrants living in the UK: an ethnographic study. BMC Public Health. 2025 Aug 22; 25(1):2883. Onuorah L, Santy-Tomlinson J, Draper P. PMID: 40846934; PMCID: PMC12372270.
      View in: PubMed   Mentions:    Fields:    
    2. Outcomes of robotic and endoscopic combined aortic and mitral valve surgery: experience from National Taiwan University Hospital. Ann Cardiothorac Surg. 2025 May 31; 14(3):210-217. Wei LY, Chen JW, Chou NK, Wang YC, Huang CH, Yu HY, Chi NH. PMID: 40547423; PMCID: PMC12177771.
      View in: PubMed   Mentions:
    3. Graduate Students' Perspectives on Obtaining a Master's of Science in Respiratory Care. Respir Care. 2025 04; 70(4):384-392. Koster MS, McHenry KL, Caldwell-Chadwick BG, Null MM. PMID: 40193534.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Comparative risk of QTc prolongation induced by second-generation antipsychotics in the real world: retrospective cohort study based on a hospital information system. BJPsych Open. 2025 Mar 10; 11(2):e42. He L, Yu W, Song H, Li L, Shen Y, Zhang L, Li H. PMID: 40059385; PMCID: PMC12001931.
      View in: PubMed   Mentions:
    5. Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects. Am J Psychiatry. 2024 Jul 01; 181(7):639-650. Ironside M, Duda JM, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Chen X, Chen X, Nickerson LD, Null KE, Esfand SM, Alexander MM, Crowley DJ, Lauze M, Misra M, Goldstein JM, Pizzagalli DA. PMID: 38685857; PMCID: PMC11216878.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. [Determination of trace anions in battery-grade lithium carbonate by double-inhibition on-line matrix-removal ion chromatography]. Se Pu. 2024 Mar 08; 42(3):291-295. Wu G, Wu GQ. PMID: 38503706; PMCID: PMC10951807.
      View in: PubMed   Mentions:    Fields:    
    7. Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity. Autophagy. 2023 08; 19(8):2257-2274. Li J, Li J, Zhou Y, Zhao W, Zhao W, Liu J, Ullah R, Fang P, Fang L, Xiao S. PMID: 36779599; PMCID: PMC10351467.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    8. [Simultaneous determination of 28 fragrance components in cosmetics by gas chromatography-tandem mass spectrometry]. Se Pu. 2023 Jan; 41(1):76-86. Xu D, Wu Y, Wang Y, Chen F, Chen F, Zhang S, Lai G. PMID: 36633079; PMCID: PMC9841437.
      View in: PubMed   Mentions: 1     Fields:    
    9. [Determination of organophosphate diesters in facility vegetable soils using ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry]. Se Pu. 2023 Jan; 41(1):58-65. Liu M, Wang M, Zhao A, Zhao A, Zhu L, Wang C, Wei C, Liu W, Xu J. PMID: 36633077; PMCID: PMC9837671.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease. Autophagy. 2023 07; 19(7):2166-2169. Montégut L, Joseph A, Chen H, Chen H, Abdellatif M, Ruckenstuhl C, Martins I, Madeo F, Kroemer G. PMID: 36579946; PMCID: PMC10283417.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    11. Robotic mitral valve repair in National Taiwan University Hospital: 10-year results. Ann Cardiothorac Surg. 2022 Nov; 11(6):605-613. Chou NK, Wang YC, Huang CH, Chi NH. PMID: 36483617; PMCID: PMC9723526.
      View in: PubMed   Mentions:
    12. Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol. 2022 Sep; 24(9):1445. Gil J, Bernard D, Martínez D, Beach D. PMID: 35941232.
      View in: PubMed   Mentions: 1     Fields:    
    13. [Plasma metabolomics in a deep vein thrombosis rat model based on ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry]. Se Pu. 2022 Aug; 40(8):736-745. Gu Y, Zang P, Li J, Li J, Yan Y, Wang J. PMID: 35903841; PMCID: PMC9404070.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    14. Autophagy and its mediated mitochondrial quality control maintain pollen tube growth and male fertility in Arabidopsis. Autophagy. 2023 03; 19(3):768-783. Yan H, Zhuang M, Xu X, Li S, Li S, Yang M, Li N, Du X, Hu K, Peng X, Huang W, Wu H, Tse YC, Zhao L, Wang H. PMID: 35786359; PMCID: PMC9980518.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    15. Bidirectional Glenn shunt with tricuspid valve resection in patients with infective endocarditis. JTCVS Tech. 2022 Jun; 13:58-61. Wang YC, Chen YS, Chi NH, Huang SC. PMID: 35711237; PMCID: PMC9196930.
      View in: PubMed   Mentions:
    16. Retrograde arterial perfusion and its outcome in robotic mitral-valve surgery. Asian J Surg. 2022 Oct; 45(10):1849-1854. Wang YC, Chi NH, Wang YC, Chen YS, Huang CH. PMID: 34840044.
      View in: PubMed   Mentions:
    17. Outcome of urgent desensitization in sensitized heart transplant recipients. J Formos Med Assoc. 2022 May; 121(5):969-977. Fu HY, Wang YC, Tsao CI, Yu SH, Chen YS, Chou HW, Chi NH, Wang CH, Hsu RB, Huang SC, Yu HY, Chou NK. PMID: 34340891.
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    18. Uniform criteria for total hip replacement surgery in patients with hip osteoarthritis: a decision tool to guide treatment decisions. Int J Qual Health Care. 2021 Mar 04; 33(1). Atsma F, Molenkamp O, Bouma H, Bolder SB, Groenewoud AS, Westert GP. PMID: 33616656; PMCID: PMC7941208.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Injury, Illness, and Mental Health Risks in United States Domestic Mariners. J Occup Environ Med. 2020 10; 62(10):839-841. Lefkowitz RY, Null DB, Slade MD, Redlich CA. PMID: 32769797.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity. Cell Metab. 2020 06 02; 31(6):1173-1188.e5. Paschoal VA, Walenta E, Talukdar S, Pessentheiner AR, Osborn O, Hah N, Chi TJ, Tye GL, Armando AM, Evans RM, Chi NW, Quehenberger O, Olefsky JM, Oh DY. PMID: 32413335; PMCID: PMC7337476.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    21. Imaging examination, diagnosis, and control and prevention of nosocomial infection for coronavirus disease 2019: Expert consensus of Hunan radiologist. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Mar 28; 45(3):221-228. Liu J, Liu J, Wang W. PMID: 32386011.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    22. 2019 Focused Update of the Guidelines of the Taiwan Society of Cardiology for the Diagnosis and Treatment of Heart Failure. Acta Cardiol Sin. 2019 May; 35(3):244-283. Wang CC, Wu CK, Tsai ML, Lee CM, Huang WC, Chou HH, Huang JL, Chi NH, Yen HW, Tzeng BH, Chang WT, Chang HY, Wang CH, Lu YY, Tsai JP, Su CH, Cherng WJ, Yin WH, Tsai CT, Wu YW, Lin JL, Hwang JJ. PMID: 31249457; PMCID: PMC6533577.
      View in: PubMed   Mentions:
    23. Outcome Prediction of Acute Kidney Injury Biomarkers at Initiation of Dialysis in Critical Units. J Clin Med. 2018 Aug 06; 7(8). Wu VC, Shiao CC, Chi NH, Wang CH, Chueh SJ, Liou HH, Spapen HD, Honore PM, Chu TS. PMID: 30082648; PMCID: PMC6112021.
      View in: PubMed   Mentions: 16  
    24. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 05; 67(5):841-848. Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. PMID: 29432123; PMCID: PMC6463753.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    25. Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion. Cell Tissue Res. 2017 06; 368(3):487-501. Wollam J, Mahata S, Riopel M, Hernandez-Carretero A, Biswas A, Bandyopadhyay GK, Chi NW, Eiden LE, Mahapatra NR, Corti A, Webster NJG, Mahata SK. PMID: 28220294; PMCID: PMC10843982.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    26. Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol. 2017 02; 232(2):137-153. Tang K, Pasqua T, Biswas A, Mahata S, Tang J, Tang A, Bandyopadhyay GK, Sinha-Hikim AP, Chi NW, Webster NJ, Corti A, Mahata SK. PMID: 27799464; PMCID: PMC5287349.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. A Young Woman With Recurrent Gestational Hypercalcemia and Acute Pancreatitis Caused by CYP24A1 Deficiency. J Bone Miner Res. 2016 10; 31(10):1841-1844. Woods GN, Saitman A, Gao H, Clarke NJ, Fitzgerald RL, Chi NW. PMID: 27105398; PMCID: PMC5071127.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    28. The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice. Diabetologia. 2016 Mar; 59(3):582-91. Zhong L, Ding Y, Bandyopadhyay G, Waaler J, Börgeson E, Smith S, Zhang M, Phillips SA, Mahooti S, Mahata SK, Shao J, Krauss S, Chi NW. PMID: 26631215.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    29. Strongyloides stercoralis Hyperinfection Syndrome Presenting as Severe, Recurrent Gastrointestinal Bleeding, Leading to a Diagnosis of Cushing Disease. Am J Trop Med Hyg. 2015 Oct; 93(4):822-7. Yee B, Chi NW, Hansen LA, Lee RR, U HS, Savides TJ, Vinetz JM. PMID: 26195463; PMCID: PMC4596606.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    30. Metastatic breast cancer with right ventricular erosion. Eur J Cardiothorac Surg. 2016 Mar; 49(3):1006-7. Chou WH, Chi NH, Wang YC, Huang CH. PMID: 25890934.
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    31. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. PMID: 25876076; PMCID: PMC4395342.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    32. Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. Endocrinology. 2014 Oct; 155(10):3793-805. Vu CU, Siddiqui JA, Wadensweiler P, Gayen JR, Avolio E, Bandyopadhyay GK, Biswas N, Chi NW, O'Connor DT, Mahata SK. PMID: 25051446.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    33. Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance. Diabetes. 2015 Jan; 64(1):104-16. Bandyopadhyay GK, Lu M, Avolio E, Siddiqui JA, Gayen JR, Wollam J, Vu CU, Chi NW, O'Connor DT, Mahata SK. PMID: 25048197.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    34. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. PMID: 24789228; PMCID: PMC4008632.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    35. C/EBPα regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. PMID: 24691027; PMCID: PMC4025063.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    36. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. PMID: 24531262; PMCID: PMC4077285.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    37. Cardiac repair using chitosan-hyaluronan/silk fibroin patches in a rat heart model with myocardial infarction. Carbohydr Polym. 2013 Jan 30; 92(1):591-7. Chi NH, Yang MC, Chung TW, Chou NK, Wang SS. PMID: 23218340.
      View in: PubMed   Mentions:
    38. Cardiac repair achieved by bone marrow mesenchymal stem cells/silk fibroin/hyaluronic acid patches in a rat of myocardial infarction model. Biomaterials. 2012 Aug; 33(22):5541-51. Chi NH, Yang MC, Chung TW, Chen JY, Chou NK, Wang SS. PMID: 22575829.
      View in: PubMed   Mentions:
    39. Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling. J Biol Chem. 2012 Jun 29; 287(27):23141-51. Bandyopadhyay GK, Vu CU, Gentile S, Lee H, Biswas N, Chi NW, O'Connor DT, Mahata SK. PMID: 22535963; PMCID: PMC3391131.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    40. Neurexin-1α contributes to insulin-containing secretory granule docking. J Biol Chem. 2012 Feb 24; 287(9):6350-61. Mosedale M, Egodage S, Calma RC, Chi NW, Chessler SD. PMID: 22235116; PMCID: PMC3307300.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    41. The influence of rat mesenchymal stem cell CD44 surface markers on cell growth, fibronectin expression, and cardiomyogenic differentiation on silk fibroin - Hyaluronic acid cardiac patches. Biomaterials. 2010 Feb; 31(5):854-62. Yang MC, Chi NH, Chou NK, Huang YY, Chung TW, Chang YL, Liu HC, Shieh MJ, Wang SS. PMID: 19857893.
      View in: PubMed   Mentions:
    42. Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice. Diabetes. 2009 Nov; 58(11):2476-85. Yeh TY, Beiswenger KK, Li P, Bolin KE, Lee RM, Tsao TS, Murphy AN, Hevener AL, Chi NW. PMID: 19651815; PMCID: PMC2768175.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    43. The cardiomyogenic differentiation of rat mesenchymal stem cells on silk fibroin-polysaccharide cardiac patches in vitro. Biomaterials. 2009 Aug; 30(22):3757-65. Yang MC, Wang SS, Chou NK, Chi NH, Huang YY, Chang YL, Shieh MJ, Chung TW. PMID: 19410289.
      View in: PubMed   Mentions:
    44. Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase. Biochem J. 2007 Mar 01; 402(2):279-90. Yeh TY, Sbodio JI, Tsun ZY, Luo B, Chi NW. PMID: 17059388; PMCID: PMC1798437.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    45. Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly(ADP-ribosyl)ation. Biochem J. 2006 Nov 01; 399(3):415-25. Yeh TY, Meyer TN, Schwesinger C, Tsun ZY, Lee RM, Chi NW. PMID: 16884355; PMCID: PMC1615909.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    46. Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3. Biochem Biophys Res Commun. 2006 Nov 24; 350(3):574-9. Yeh TY, Sbodio JI, Chi NW. PMID: 17026964.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    47. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2005 Oct 21; 280(42):35361-71. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky JM. PMID: 16085647.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    48. Tankyrase-1 overexpression reduces genotoxin-induced cell death by inhibiting PARP1. Mol Cell Biochem. 2005 Aug; 276(1-2):183-92. Yeh TY, Sbodio JI, Nguyen MT, Meyer TN, Lee RM, Chi NW. PMID: 16132700.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    49. Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. J Biol Chem. 2002 Aug 30; 277(35):31887-92. Sbodio JI, Chi NW. PMID: 12080061.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    50. Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J. 2002 Feb 01; 361(Pt 3):451-9. Sbodio JI, Lodish HF, Chi NW. PMID: 11802774; PMCID: PMC1222327.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
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