-
Allosteric couplings upon binding of RfaH to transcription elongation complexes. Nucleic Acids Res. 2022 Jun 07.
Molina JA, Galaz-Davison P, Komives EA, Artsimovitch I, Ramírez-Sarmiento CA. PMID: 35670666.
View in:
PubMed Mentions:
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Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release. Elife. 2022 05 31; 11.
Bibel B, Elkayam E, Silletti S, Komives EA, Joshua-Tor L. PMID: 35638597.
View in:
PubMed Mentions:
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Dimer dissociation is a key energetic event in the fold-switch pathway of KaiB. Biophys J. 2022 03 15; 121(6):943-955.
Rivera M, Galaz-Davison P, Retamal-Farfán I, Komives EA, Ramírez-Sarmiento CA. PMID: 35151633; PMCID: PMC8943816.
View in:
PubMed Mentions:
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How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen. Biochemistry. 2022 01 18; 61(2):77-84.
Peacock RB, McGrann T, Zaragoza S, Komives EA. PMID: 34978431.
View in:
PubMed Mentions:
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Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation. Nucleic Acids Res. 2021 11 08; 49(19):11211-11223.
Chen W, Lu W, Wolynes PG, Komives EA. PMID: 34614173; PMCID: PMC8565325.
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PubMed Mentions: Fields:
-
Achieving a realistic native protein ensemble by HDX-MS and computational modeling. Biophys J. 2021 12 07; 120(23):5139-5140.
Komives EA. PMID: 34742401; PMCID: PMC8715172.
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PubMed Mentions:
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Development of a Rapid and Sensitive CasRx-Based Diagnostic Assay for SARS-CoV-2. ACS Sens. 2021 11 26; 6(11):3957-3966.
Brogan DJ, Chaverra-Rodriguez D, Lin CP, Smidler AL, Yang T, Alcantara LM, Antoshechkin I, Liu J, Raban RR, Belda-Ferre P, Knight R, Komives EA, Akbari OS. PMID: 34714054; PMCID: PMC8577378.
View in:
PubMed Mentions:
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Open, engage, bind, translocate: The multi-level dynamics of bacterial protein translocation. Structure. 2021 08 05; 29(8):781-782.
Chen W, Komives EA. PMID: 34358463.
View in:
PubMed Mentions: Fields:
-
Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin. Biochemistry. 2021 11 23; 60(46):3441-3448.
Peacock RB, Komives EA. PMID: 34159782.
View in:
PubMed Mentions: Fields:
-
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Proc Natl Acad Sci U S A. 2021 06 08; 118(23).
Schmidt SH, Weng JH, Aoto PC, Boassa D, Mathea S, Silletti S, Hu J, Wallbott M, Komives EA, Knapp S, Herberg FW, Taylor SS. PMID: 34088839; PMCID: PMC8201809.
View in:
PubMed Mentions:
1 Fields:
-
Transcription factor NF-κB unravels nucleosomes. Biochim Biophys Acta Gen Subj. 2021 09; 1865(9):129934.
Stormberg T, Filliaux S, Baughman HER, Komives EA, Lyubchenko YL. PMID: 34029641; PMCID: PMC8277743.
View in:
PubMed Mentions: Fields:
-
Serine protease dynamics revealed by NMR analysis of the thrombin-thrombomodulin complex. Sci Rep. 2021 04 30; 11(1):9354.
Peacock RB, McGrann T, Tonelli M, Komives EA. PMID: 33931701; PMCID: PMC8087772.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
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Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability. FEBS J. 2021 07; 288(13):4000-4023.
Hoffmeister H, Fuchs A, Komives E, Groebner-Ferreira R, Strobl L, Nazet J, Heizinger L, Merkl R, Dove S, Längst G. PMID: 33403747.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
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The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases. Mol Cell Proteomics. 2021; 20:100019.
Lumpkin RJ, Ahmad AS, Blake R, Condon CJ, Komives EA. PMID: 33268465; PMCID: PMC7950132.
View in:
PubMed Mentions:
1 Fields:
-
Surveying biomolecular frustration at atomic resolution. Nat Commun. 2020 11 23; 11(1):5944.
Chen M, Chen X, Schafer NP, Clementi C, Komives EA, Ferreiro DU, Wolynes PG. PMID: 33230150; PMCID: PMC7683549.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
-
A Sensitive, Rapid, and Portable CasRx-based Diagnostic Assay for SARS-CoV-2. medRxiv. 2020 Oct 20.
Brogan DJ, Chaverra-Rodriguez D, Lin CP, Smidler AL, Yang T, Alcantara LM, Antoshechkin I, Liu J, Raban RR, Belda-Ferre P, Knight R, Komives EA, Akbari OS. PMID: 33106816; PMCID: PMC7587836.
View in:
PubMed Mentions:
-
Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping. J Mol Biol. 2020 09 04; 432(19):5411-5429.
Medina E, Villalobos P, Hamilton GL, Komives EA, Sanabria H, Ramírez-Sarmiento CA, Babul J. PMID: 32735805; PMCID: PMC7663421.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nat Commun. 2020 06 08; 11(1):2866.
Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. PMID: 32513959; PMCID: PMC7280518.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Complementarity of Hydrogen/Deuterium Exchange Mass Spectrometry and Cryo-Electron Microscopy. Trends Biochem Sci. 2020 10; 45(10):906-918.
Engen JR, Komives EA. PMID: 32487353; PMCID: PMC7502526.
View in:
PubMed Mentions:
1 Fields:
-
Differential Local Stability Governs the Metamorphic Fold Switch of Bacterial Virulence Factor RfaH. Biophys J. 2020 01 07; 118(1):96-104.
Galaz-Davison P, Molina JA, Silletti S, Komives EA, Knauer SH, Artsimovitch I, Ramírez-Sarmiento CA. PMID: 31810657; PMCID: PMC6950767.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
-
Decoupling a tandem-repeat protein: Impact of multiple loop insertions on a modular scaffold. Sci Rep. 2019 10 28; 9(1):15439.
Perez-Riba A, Komives E, Main ERG, Itzhaki LS. PMID: 31659184; PMCID: PMC6817815.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
-
Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. Sci Rep. 2019 10 22; 9(1):15092.
Kopcho N, Chang G, Komives EA. PMID: 31641149; PMCID: PMC6805939.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
DECA, A Comprehensive, Automatic Post-processing Program for HDX-MS Data. Mol Cell Proteomics. 2019 12; 18(12):2516-2523.
Lumpkin RJ, Komives EA. PMID: 31594786; PMCID: PMC6885705.
View in:
PubMed Mentions:
7 Fields:
-
Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16394-16403.
Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I. PMID: 31363053; PMCID: PMC6697900.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Cryo-EM structure of OSCA1.2 from Oryza sativa elucidates the mechanical basis of potential membrane hyperosmolality gating. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14309-14318.
Maity K, Heumann JM, McGrath AP, Kopcho NJ, Hsu PK, Lee CW, Mapes JH, Garza D, Krishnan S, Morgan GP, Hendargo KJ, Klose T, Rees SD, Medrano-Soto A, Saier MH, Piñeros M, Komives EA, Schroeder JI, Chang G, Stowell MHB. PMID: 31227607; PMCID: PMC6628804.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Exclusivity and Compensation in NFκB Dimer Distributions and IκB Inhibition. Biochemistry. 2019 05 28; 58(21):2555-2563.
Ramsey KM, Chen W, Marion JD, Bergqvist S, Komives EA. PMID: 31033276; PMCID: PMC6642826.
View in:
PubMed Mentions: Fields:
Translation:
AnimalsCells
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Accurate Prediction of Amide Exchange in the Fast Limit Reveals Thrombin Allostery. Biophys J. 2019 01 08; 116(1):49-56.
Markwick PRL, Peacock RB, Komives EA. PMID: 30558884; PMCID: PMC6342732.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Deciphering and engineering chromodomain-methyllysine peptide recognition. Sci Adv. 2018 11; 4(11):eaau1447.
Hard R, Li N, He W, Ross B, Mo GCH, Peng Q, Stein RSL, Komives E, Wang Y, Zhang J, Wang W. PMID: 30417094; PMCID: PMC6221542.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Calcium sensing by the STIM1 ER-luminal domain. Nat Commun. 2018 10 31; 9(1):4536.
Gudlur A, Zeraik AE, Hirve N, Rajanikanth V, Bobkov AA, Ma G, Zheng S, Wang Y, Zhou Y, Komives EA, Hogan PG. PMID: 30382093; PMCID: PMC6208404.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Prediction of the presence of a seventh ankyrin repeat in IκBε from homology modeling combined with hydrogen-deuterium exchange mass spectrometry (HDX-MS). Protein Sci. 2018 09; 27(9):1624-1635.
Ramsey KM, Narang D, Komives EA. PMID: 30133030; PMCID: PMC6194264.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation. Nat Struct Mol Biol. 2018 08; 25(8):687-697.
Rahnamoun H, Lee J, Sun Z, Lu H, Ramsey KM, Komives EA, Lauberth SM. PMID: 30076409; PMCID: PMC6859054.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansCells
-
Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin. Biochemistry. 2018 05 08; 57(18):2694-2703.
Peacock RB, Davis JR, Markwick PRL, Komives EA. PMID: 29634247; PMCID: PMC5940494.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions. Methods. 2018 07 15; 144:43-52.
Ramirez-Sarmiento CA, Komives EA. PMID: 29627358; PMCID: PMC6051914.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
RelA-Containing NFκB Dimers Have Strikingly Different DNA-Binding Cavities in the Absence of DNA. J Mol Biol. 2018 05 11; 430(10):1510-1520.
Narang D, Chen W, Ricci CG, Komives EA. PMID: 29625198; PMCID: PMC5951767.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation. PLoS One. 2018; 13(2):e0192661.
Kromann-Hansen T, Lange EL, Lund IK, Høyer-Hansen G, Andreasen PA, Komives EA. PMID: 29420634; PMCID: PMC5805342.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. Nucleic Acids Res. 2018 01 09; 46(1):279-292.
West AMV, Komives EA, Corbett KD. PMID: 29186573; PMCID: PMC5758881.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Resolving the NFκB Heterodimer Binding Paradox: Strain and Frustration Guide the Binding of Dimeric Transcription Factors. J Am Chem Soc. 2017 12 27; 139(51):18558-18566.
Potoyan DA, Bueno C, Zheng W, Komives EA, Wolynes PG. PMID: 29183131; PMCID: PMC5803749.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
-
Structural Basis for Shelterin Bridge Assembly. Mol Cell. 2017 Nov 16; 68(4):698-714.e5.
Kim JK, Liu J, Hu X, Yu C, Roskamp K, Sankaran B, Huang L, Komives EA, Qiao F. PMID: 29149597; PMCID: PMC5698806.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
Frustration, function and folding. Curr Opin Struct Biol. 2018 02; 48:68-73.
Ferreiro DU, Komives EA, Wolynes PG. PMID: 29101782; PMCID: PMC6005193.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun. 2017 10 27; 8(1):1171.
Lumpkin RJ, Gu H, Zhu Y, Leonard M, Ahmad AS, Clauser KR, Meyer JG, Bennett EJ, Komives EA. PMID: 29079793; PMCID: PMC5660086.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansCells
-
Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation. Nat Commun. 2017 10 03; 8(1):781.
Wong JJW, Young TA, Zhang J, Liu S, Leser GP, Komives EA, Lamb RA, Zhou ZH, Salafsky J, Jardetzky TS. PMID: 28974687; PMCID: PMC5626764.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep. 2017 06 13; 7(1):3385.
Kromann-Hansen T, Louise Lange E, Peter Sørensen H, Hassanzadeh-Ghassabeh G, Huang M, Jensen JK, Muyldermans S, Declerck PJ, Komives EA, Andreasen PA. PMID: 28611361; PMCID: PMC5469797.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Unusual dimerization of a BcCsp mutant leads to reduced conformational dynamics. FEBS J. 2017 06; 284(12):1882-1896.
Carvajal AI, Vallejos G, Komives EA, Castro-Fernández V, Leonardo DA, Garratt RC, Ramírez-Sarmiento CA, Babul J. PMID: 28457014; PMCID: PMC5505725.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
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DNA and IκBα Both Induce Long-Range Conformational Changes in NFκB. J Mol Biol. 2017 04 07; 429(7):999-1008.
Ramsey KM, Dembinski HE, Chen W, Ricci CG, Komives EA. PMID: 28249778; PMCID: PMC5389416.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):1916-1921.
Dembinski HE, Wismer K, Vargas JD, Suryawanshi GW, Kern N, Kroon G, Dyson HJ, Hoffmann A, Komives EA. PMID: 28167786; PMCID: PMC5338396.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
-
NMR reveals a dynamic allosteric pathway in thrombin. Sci Rep. 2017 01 06; 7:39575.
Handley LD, Fuglestad B, Stearns K, Tonelli M, Fenwick RB, Markwick PR, Komives EA. PMID: 28059082; PMCID: PMC5216386.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
-
Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer. Structure. 2016 08 02; 24(8):1248-1256.
Schiffer JM, Malmstrom RD, Parnell J, Ramirez-Sarmiento C, Reyes J, Amaro RE, Komives EA. PMID: 27396830; PMCID: PMC4972691.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1. Biophys J. 2016 06 07; 110(11):2349-2360.
Medina E, Córdova C, Villalobos P, Reyes J, Komives EA, Ramírez-Sarmiento CA, Babul J. PMID: 27276253; PMCID: PMC4922571.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Structural characterization of the ternary complex that mediates termination of NF-κB signaling by IκBα. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6212-7.
Mukherjee SP, Quintas PO, McNulty R, Komives EA, Dyson HJ. PMID: 27185953; PMCID: PMC4896678.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
PEST Control of Molecular Stripping of NFκB from DNA Transcription Sites. J Phys Chem B. 2016 08 25; 120(33):8532-8.
Potoyan DA, Zheng W, Ferreiro DU, Wolynes PG, Komives EA. PMID: 27098223; PMCID: PMC5389414.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
-
Binding of NFκB Appears to Twist the Ankyrin Repeat Domain of IκBα. Biophys J. 2016 Feb 23; 110(4):887-95.
Trelle MB, Ramsey KM, Lee TC, Zheng W, Lamboy J, Wolynes PG, Deniz A, Komives EA. PMID: 26910425; PMCID: PMC4776026.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Molecular stripping in the NF-κB/IκB/DNA genetic regulatory network. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):110-5.
Potoyan DA, Zheng W, Komives EA, Wolynes PG. PMID: 26699500; PMCID: PMC4711861.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
-
Thrombomodulin Binding Selects the Catalytically Active Form of Thrombin. Biochemistry. 2015 Nov 03; 54(43):6650-8.
Handley LD, Treuheit NA, Venkatesh VJ, Komives EA. PMID: 26468766; PMCID: PMC4697735.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
The folding unit of phosphofructokinase-2 as defined by the biophysical properties of a monomeric mutant. Biophys J. 2015 May 05; 108(9):2350-61.
Ramírez-Sarmiento CA, Baez M, Zamora RA, Balasubramaniam D, Babul J, Komives EA, Guixé V. PMID: 25954892; PMCID: PMC4423062.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
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Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. Arch Toxicol. 2016 Mar; 90(3):603-16.
Mangas I, Taylor P, Vilanova E, Estévez J, França TC, Komives E, Radic Z. PMID: 25743373; PMCID: PMC4833118.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
How the ankyrin and SOCS box protein, ASB9, binds to creatine kinase. Biochemistry. 2015 Mar 03; 54(8):1673-80.
Balasubramaniam D, Schiffer J, Parnell J, Mir SP, Amaro RE, Komives EA. PMID: 25654263; PMCID: PMC4348336.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Frustration in biomolecules. Q Rev Biophys. 2014 Nov; 47(4):285-363.
Ferreiro DU, Komives EA, Wolynes PG. PMID: 25225856; PMCID: PMC4256721.
View in:
PubMed Mentions:
76 Fields:
Translation:
Humans
-
Trypsinogen activation as observed in accelerated molecular dynamics simulations. Protein Sci. 2014 Nov; 23(11):1550-8.
Boechi L, Pierce L, Komives EA, McCammon JA. PMID: 25131668; PMCID: PMC4241106.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
-
Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA. Biochim Biophys Acta. 2014 Sep; 1840(9):2851-61.
Perera VR, Newton GL, Parnell JM, Komives EA, Pogliano K. PMID: 24821014; PMCID: PMC4802972.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
The phylogenetics of dynamics in DNA clamp proteins. Structure. 2014 Apr 08; 22(4):511-2.
Balasubramaniam D, Komives EA. PMID: 24717558.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
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Predicted disorder-to-order transition mutations in IκBα disrupt function. Phys Chem Chem Phys. 2014 Apr 14; 16(14):6480-5.
Dembinski H, Wismer K, Balasubramaniam D, Gonzalez HA, Alverdi V, Iakoucheva LM, Komives EA. PMID: 24605363; PMCID: PMC4040282.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
-
Expanding proteome coverage with orthogonal-specificity α-lytic proteases. Mol Cell Proteomics. 2014 Mar; 13(3):823-35.
Meyer JG, Kim S, Maltby DA, Ghassemian M, Bandeira N, Komives EA. PMID: 24425750; PMCID: PMC3945911.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
Direct observation of a transient ternary complex during IκBα-mediated dissociation of NF-κB from DNA. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):225-30.
Alverdi V, Hetrick B, Joseph S, Komives EA. PMID: 24367071; PMCID: PMC3890772.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Identification of methyllysine peptides binding to chromobox protein homolog 6 chromodomain in the human proteome. Mol Cell Proteomics. 2013 Oct; 12(10):2750-60.
Li N, Stein RS, He W, Komives E, Wang W. PMID: 23842000; PMCID: PMC3790288.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Correlated motions and residual frustration in thrombin. J Phys Chem B. 2013 Oct 24; 117(42):12857-63.
Fuglestad B, Gasper PM, McCammon JA, Markwick PR, Komives EA. PMID: 23621631; PMCID: PMC3808083.
View in:
PubMed Mentions:
19 Fields:
Translation:
Cells
-
Observation of solvent penetration during cold denaturation of E. coli phosphofructokinase-2. Biophys J. 2013 May 21; 104(10):2254-63.
Ramírez-Sarmiento CA, Baez M, Wilson CA, Babul J, Komives EA, Guixé V. PMID: 23708365; PMCID: PMC3660636.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
-
Single-molecule FRET reveals the native-state dynamics of the IκBα ankyrin repeat domain. J Mol Biol. 2013 Jul 24; 425(14):2578-90.
Lamboy JA, Kim H, Dembinski H, Ha T, Komives EA. PMID: 23619335; PMCID: PMC3758917.
View in:
PubMed Mentions:
7 Fields:
Translation:
Cells
-
Recognition of methylated peptides by Drosophila melanogaster polycomb chromodomain. J Proteome Res. 2013 Mar 01; 12(3):1467-77.
Stein RS, Li N, He W, Komives E, Wang W. PMID: 23320494; PMCID: PMC4258113.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Long-range effects and functional consequences of stabilizing mutations in the ankyrin repeat domain of IκBα. J Mol Biol. 2013 Mar 11; 425(5):902-13.
Cervantes CF, Handley LD, Sue SC, Dyson HJ, Komives EA. PMID: 23274114; PMCID: PMC3744861.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Discrete kinetic models from funneled energy landscape simulations. PLoS One. 2012; 7(12):e50635.
Schafer NP, Hoffman RM, Burger A, Craig PO, Komives EA, Wolynes PG. PMID: 23251375; PMCID: PMC3520928.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21216-22.
Gasper PM, Fuglestad B, Komives EA, Markwick PR, McCammon JA. PMID: 23197839; PMCID: PMC3535651.
View in:
PubMed Mentions:
66 Fields:
Translation:
Cells
-
Hydrogen-exchange mass spectrometry for the study of intrinsic disorder in proteins. Biochim Biophys Acta. 2013 Jun; 1834(6):1202-9.
Balasubramaniam D, Komives EA. PMID: 23099262; PMCID: PMC3600394.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
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The dynamic structure of thrombin in solution. Biophys J. 2012 Jul 03; 103(1):79-88.
Fuglestad B, Gasper PM, Tonelli M, McCammon JA, Markwick PR, Komives EA. PMID: 22828334; PMCID: PMC3388214.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Toxicol Sci. 2012 Sep; 129(1):200-12.
Guo L, Ghassemian M, Komives EA, Russell P. PMID: 22610605; PMCID: PMC3713068.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Role of disorder in IκB-NFκB interaction. IUBMB Life. 2012 Jun; 64(6):499-505.
Dyson HJ, Komives EA. PMID: 22573609; PMCID: PMC3575514.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
-
Feedback inhibition by thiols outranks glutathione depletion: a luciferase-based screen reveals glutathione-deficient γ-ECS and glutathione synthetase mutants impaired in cadmium-induced sulfate assimilation. Plant J. 2012 Jun; 70(5):783-95.
Jobe TO, Sung DY, Akmakjian G, Pham A, Komives EA, Mendoza-Cózatl DG, Schroeder JI. PMID: 22283708; PMCID: PMC4688143.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Consequences of fuzziness in the NFκB/IκBα interaction. Adv Exp Med Biol. 2012; 725:74-85.
Komives EA. PMID: 22399319; PMCID: PMC3603378.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
-
The structure, dynamics, and binding of the LA45 module pair of the low-density lipoprotein receptor suggest an important role for LA4 in ligand release. Biochemistry. 2011 Dec 27; 50(51):11001-8.
Guttman M, Komives EA. PMID: 22091758; PMCID: PMC3263374.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Prediction of native-state hydrogen exchange from perfectly funneled energy landscapes. J Am Chem Soc. 2011 Nov 02; 133(43):17463-72.
Craig PO, Lätzer J, Weinkam P, Hoffman RM, Ferreiro DU, Komives EA, Wolynes PG. PMID: 21913704; PMCID: PMC3203634.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansCells
-
Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein. Biochemistry. 2011 Jul 19; 50(28):6208-16.
Mulvihill MM, Guttman M, Komives EA. PMID: 21650223; PMCID: PMC3139566.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Visualization of the nanospring dynamics of the IkappaBalpha ankyrin repeat domain in real time. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10178-83.
Lamboy JA, Kim H, Lee KS, Ha T, Komives EA. PMID: 21628581; PMCID: PMC3121830.
View in:
PubMed Mentions:
20 Fields:
Translation:
Cells
-
Thermodynamic compensation upon binding to exosite 1 and the active site of thrombin. Biochemistry. 2011 May 31; 50(21):4590-6.
Treuheit NA, Beach MA, Komives EA. PMID: 21526769; PMCID: PMC3107735.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Folding kinetics of the cooperatively folded subdomain of the IκBα ankyrin repeat domain. J Mol Biol. 2011 Apr 22; 408(1):163-76.
DeVries I, Ferreiro DU, Sánchez IE, Komives EA. PMID: 21329696; PMCID: PMC3081522.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
-
On the role of frustration in the energy landscapes of allosteric proteins. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3499-503.
Ferreiro DU, Hegler JA, Komives EA, Wolynes PG. PMID: 21273505; PMCID: PMC3048099.
View in:
PubMed Mentions:
59 Fields:
Translation:
Cells
-
Detection of a ternary complex of NF-kappaB and IkappaBalpha with DNA provides insights into how IkappaBalpha removes NF-kappaB from transcription sites. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1367-72.
Sue SC, Alverdi V, Komives EA, Dyson HJ. PMID: 21220295; PMCID: PMC3029698.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
-
The RelA nuclear localization signal folds upon binding to IκBα. J Mol Biol. 2011 Jan 21; 405(3):754-64.
Cervantes CF, Bergqvist S, Kjaergaard M, Kroon G, Sue SC, Dyson HJ, Komives EA. PMID: 21094161; PMCID: PMC3056351.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
Consequences of IkappaB alpha hydroxylation by the factor inhibiting HIF (FIH). FEBS Lett. 2010 Dec 01; 584(23):4725-30.
Devries IL, Hampton-Smith RJ, Mulvihill MM, Alverdi V, Peet DJ, Komives EA. PMID: 21056038; PMCID: PMC3034650.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Flexible regions within I{kappa}B{alpha} create the ubiquitin-independent degradation signal. J Biol Chem. 2010 Oct 22; 285(43):32927-32936.
Mathes E, Wang L, Komives E, Ghosh G. PMID: 20682784; PMCID: PMC2963393.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Critical salt bridges guide capsid assembly, stability, and maturation behavior in bacteriophage HK97. Mol Cell Proteomics. 2010 Aug; 9(8):1752-63.
Gertsman I, Fu CY, Huang R, Komives EA, Johnson JE. PMID: 20332083; PMCID: PMC2938056.
View in:
PubMed Mentions:
20 Fields:
Translation:
Cells
-
Structure of the minimal interface between ApoE and LRP. J Mol Biol. 2010 Apr 30; 398(2):306-19.
Guttman M, Prieto JH, Handel TM, Domaille PJ, Komives EA. PMID: 20303980; PMCID: PMC2880916.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansCells
-
Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha. Biochemistry. 2010 Mar 02; 49(8):1560-7.
Ferreiro DU, Komives EA. PMID: 20055496; PMCID: PMC2865148.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
-
Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E. Biochemistry. 2010 Feb 16; 49(6):1207-16.
Guttman M, Prieto JH, Croy JE, Komives EA. PMID: 20030366; PMCID: PMC2821871.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
Enhanced conformational space sampling improves the prediction of chemical shifts in proteins. J Am Chem Soc. 2010 Feb 03; 132(4):1220-1.
Markwick PR, Cervantes CF, Abel BL, Komives EA, Blackledge M, McCammon JA. PMID: 20063881; PMCID: PMC2812018.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansCells
-
HK97 maturation studied by crystallography and H/2H exchange reveals the structural basis for exothermic particle transitions. J Mol Biol. 2010 Mar 26; 397(2):560-74.
Gertsman I, Komives EA, Johnson JE. PMID: 20093122; PMCID: PMC2855905.
View in:
PubMed Mentions:
16 Fields:
Translation:
Cells
-
Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19328-33.
Bergqvist S, Alverdi V, Mengel B, Hoffmann A, Ghosh G, Komives EA. PMID: 19887633; PMCID: PMC2780789.
View in:
PubMed Mentions:
51 Fields:
Translation:
HumansCells
-
Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1. Proteomics. 2009 Nov; 9(22):5016-28.
Guttman M, Betts GN, Barnes H, Ghassemian M, van der Geer P, Komives EA. PMID: 19771558; PMCID: PMC2862490.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
-
Functional dynamics of the folded ankyrin repeats of I kappa B alpha revealed by nuclear magnetic resonance. Biochemistry. 2009 Aug 25; 48(33):8023-31.
Cervantes CF, Markwick PR, Sue SC, McCammon JA, Dyson HJ, Komives EA. PMID: 19591507; PMCID: PMC2728578.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
-
ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis. Plant J. 2009 Sep; 59(5):802-13.
Sung DY, Kim TH, Komives EA, Mendoza-Cózatl DG, Schroeder JI. PMID: 19453443; PMCID: PMC2830867.
View in:
PubMed Mentions:
19 Fields:
Translation:
Animals
-
An unexpected twist in viral capsid maturation. Nature. 2009 Apr 02; 458(7238):646-50.
Gertsman I, Gan L, Guttman M, Lee K, Speir JA, Duda RL, Hendrix RW, Komives EA, Johnson JE. PMID: 19204733; PMCID: PMC2765791.
View in:
PubMed Mentions:
68 Fields:
Translation:
Cells
-
The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface. Protein Sci. 2008 Dec; 17(12):2051-8.
Bergqvist S, Ghosh G, Komives EA. PMID: 18824506; PMCID: PMC2590914.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
-
Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin. Biochemistry. 2008 Oct 14; 47(41):10933-9.
Koeppe JR, Beach MA, Baerga-Ortiz A, Kerns SJ, Komives EA. PMID: 18803401; PMCID: PMC2630536.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
Rapid mass spectrometric analysis of 15N-Leu incorporation fidelity during preparation of specifically labeled NMR samples. Protein Sci. 2008 Sep; 17(9):1636-9.
Truhlar SM, Cervantes CF, Torpey JW, Kjaergaard M, Komives EA. PMID: 18567787; PMCID: PMC2525515.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
-
Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex. J Mol Biol. 2008 Jul 25; 380(5):917-31.
Sue SC, Cervantes C, Komives EA, Dyson HJ. PMID: 18565540; PMCID: PMC2603615.
View in:
PubMed Mentions:
39 Fields:
Translation:
Cells
-
The energy landscapes of repeat-containing proteins: topology, cooperativity, and the folding funnels of one-dimensional architectures. PLoS Comput Biol. 2008 May 16; 4(5):e1000070.
Ferreiro DU, Walczak AM, Komives EA, Wolynes PG. PMID: 18483553; PMCID: PMC2366061.
View in:
PubMed Mentions:
33 Fields:
Translation:
Cells
-
LRR domain folding: just put a cap on it! Structure. 2008 May; 16(5):655-7.
Truhlar SM, Komives EA. PMID: 18462667.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
-
Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain. J Biol Chem. 2008 Jun 06; 283(23):15656-64.
Betts GN, van der Geer P, Komives EA. PMID: 18381291; PMCID: PMC2414285.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansCells
-
Pre-folding IkappaBalpha alters control of NF-kappaB signaling. J Mol Biol. 2008 Jun 27; 380(1):67-82.
Truhlar SM, Mathes E, Cervantes CF, Ghosh G, Komives EA. PMID: 18511071; PMCID: PMC2519148.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes. Antimicrob Agents Chemother. 2008 May; 52(5):1834-6.
Huang CM, Torpey JW, Liu YT, Chen YR, Williams KE, Komives EA, Gallo RL. PMID: 18285475; PMCID: PMC2346631.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Folding landscapes of ankyrin repeat proteins: experiments meet theory. Curr Opin Struct Biol. 2008 Feb; 18(1):27-34.
Barrick D, Ferreiro DU, Komives EA. PMID: 18243686; PMCID: PMC2680087.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus. A role for thiol-peptides in the long-distance transport of cadmium and the effect of cadmium on iron translocation. Plant J. 2008 Apr; 54(2):249-59.
Mendoza-Cózatl DG, Butko E, Springer F, Torpey JW, Komives EA, Kehr J, Schroeder JI. PMID: 18208526; PMCID: PMC2839885.
View in:
PubMed Mentions:
55 Fields:
Translation:
Animals
-
Localizing frustration in native proteins and protein assemblies. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19819-24.
Ferreiro DU, Hegler JA, Komives EA, Wolynes PG. PMID: 18077414; PMCID: PMC2148382.
View in:
PubMed Mentions:
115 Fields:
Translation:
Cells
-
Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family member. J Immunol. 2007 Oct 01; 179(7):4939-44.
Wu X, Li ZF, Brooks R, Komives EA, Torpey JW, Engvall E, Gonias SL, Shelton GD. PMID: 17878394.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. J Mol Biol. 2007 Nov 23; 374(2):487-99.
Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA, Taylor SS. PMID: 17942118; PMCID: PMC3419600.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
The plastic landscape of repeat proteins. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7735-6.
Ferreiro DU, Komives EA. PMID: 17483477; PMCID: PMC1876514.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Identification of an arsenic tolerant double mutant with a thiol-mediated component and increased arsenic tolerance in phyA mutants. Plant J. 2007 Mar; 49(6):1064-75.
Sung DY, Lee D, Harris H, Raab A, Feldmann J, Meharg A, Kumabe B, Komives EA, Schroeder JI. PMID: 17335514.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
Induced fit, folding, and recognition of the NF-kappaB-nuclear localization signals by IkappaBalpha and IkappaBbeta. J Mol Biol. 2007 Mar 16; 367(1):262-74.
Lätzer J, Papoian GA, Prentiss MC, Komives EA, Wolynes PG. PMID: 17257619.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
-
Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB.DNA interaction fold upon binding to NF-kappaB. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):18951-6.
Truhlar SM, Torpey JW, Komives EA. PMID: 17148610; PMCID: PMC1748158.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansCells
-
Stabilizing IkappaBalpha by "consensus" design. J Mol Biol. 2007 Jan 26; 365(4):1201-16.
Ferreiro DU, Cervantes CF, Truhlar SM, Cho SS, Wolynes PG, Komives EA. PMID: 17174335; PMCID: PMC1866275.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansCells
-
Solvent accessibility of protein surfaces by amide H/2H exchange MALDI-TOF mass spectrometry. J Am Soc Mass Spectrom. 2006 Nov; 17(11):1490-7.
Truhlar SM, Croy CH, Torpey JW, Koeppe JR, Komives EA. PMID: 16934999.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
Amide H/2H exchange reveals a mechanism of thrombin activation. Biochemistry. 2006 Jun 27; 45(25):7724-32.
Koeppe JR, Komives EA. PMID: 16784223; PMCID: PMC2535819.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol. 2006 Jul 07; 360(2):421-34.
Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. PMID: 16756995; PMCID: PMC2680085.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
-
An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis. Plant Physiol. 2006 May; 141(1):108-20.
Chen A, Komives EA, Schroeder JI. PMID: 16531489; PMCID: PMC1459314.
View in:
PubMed Mentions:
30 Fields:
Translation:
Animals
-
Automated extraction of backbone deuteration levels from amide H/2H mass spectrometry experiments. Protein Sci. 2006 Mar; 15(3):583-601.
Hotchko M, Anand GS, Komives EA, Ten Eyck LF. PMID: 16501228; PMCID: PMC2249778.
View in:
PubMed Mentions:
37 Fields:
-
Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry. J Biol Chem. 2006 Apr 28; 281(17):12170-7.
Shi J, Koeppe JR, Komives EA, Taylor P. PMID: 16484218.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
-
Thrombomodulin tightens the thrombin active site loops to promote protein C activation. Biochemistry. 2005 Nov 15; 44(45):14784-91.
Koeppe JR, Seitova A, Mather T, Komives EA. PMID: 16274226.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
-
The energy landscape of modular repeat proteins: topology determines folding mechanism in the ankyrin family. J Mol Biol. 2005 Dec 02; 354(3):679-92.
Ferreiro DU, Cho SS, Komives EA, Wolynes PG. PMID: 16257414.
View in:
PubMed Mentions:
48 Fields:
Translation:
Cells
-
Application of amide proton exchange mass spectrometry for the study of protein-protein interactions. Curr Protoc Protein Sci. 2005 Jun; Chapter 20:Unit20.9.
Mandell JG, Baerga-Ortiz A, Croy CH, Falick AM, Komives EA. PMID: 18429282.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
-
Dynamics of the fragment of thrombomodulin containing the fourth and fifth epidermal growth factor-like domains correlate with function. Biochemistry. 2005 Feb 01; 44(4):1225-33.
Prieto JH, Sampoli Benitez BA, Melacini G, Johnson DA, Wood MJ, Komives EA. PMID: 15667216.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
-
Structural and functional consequences of methionine oxidation in thrombomodulin. Biochim Biophys Acta. 2005 Jan 17; 1703(2):141-7.
Wood MJ, Helena Prieto J, Komives EA. PMID: 15680222.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Measurement of solvent accessibility at protein-protein interfaces. Methods Mol Biol. 2005; 305:65-80.
Mandell JG, Baerga-Ortiz A, Falick AM, Komives EA. PMID: 15939994.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci. 2004 Jul; 13(7):1767-77.
Croy CH, Bergqvist S, Huxford T, Ghosh G, Komives EA. PMID: 15215520; PMCID: PMC2279933.
View in:
PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
-
Two apolipoprotein E mimetic peptides, ApoE(130-149) and ApoE(141-155)2, bind to LRP1. Biochemistry. 2004 Jun 15; 43(23):7328-35.
Croy JE, Brandon T, Komives EA. PMID: 15182176.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansCells
-
Allosteric changes in solvent accessibility observed in thrombin upon active site occupation. Biochemistry. 2004 May 11; 43(18):5246-55.
Croy CH, Koeppe JR, Bergqvist S, Komives EA. PMID: 15122890.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
Two different proteins that compete for binding to thrombin have opposite kinetic and thermodynamic profiles. Protein Sci. 2004 Jan; 13(1):166-76.
Baerga-Ortiz A, Bergqvist S, Mandell JG, Komives EA. PMID: 14691232; PMCID: PMC2286536.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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All three LDL receptor homology regions of the LDL receptor-related protein bind multiple ligands. Biochemistry. 2003 Nov 11; 42(44):13049-57.
Croy JE, Shin WD, Knauer MF, Knauer DJ, Komives EA. PMID: 14596620.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
-
Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13264-9.
Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck LF, Komives EA. PMID: 14583592; PMCID: PMC263775.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
NMR structures reveal how oxidation inactivates thrombomodulin. Biochemistry. 2003 Oct 21; 42(41):11932-42.
Wood MJ, Becvar LA, Prieto JH, Melacini G, Komives EA. PMID: 14556624.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry. Biochemistry. 2003 Sep 23; 42(37):11083-91.
Jennings LL, Malecki M, Komives EA, Taylor P. PMID: 12974645.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation. J Mol Biol. 2002 Dec 06; 324(4):587-97.
Huxford T, Mishler D, Phelps CB, Huang DB, Sengchanthalangsy LL, Reeves R, Hughes CA, Komives EA, Ghosh G. PMID: 12460563.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. J Mol Biol. 2002 Oct 18; 323(2):377-86.
Anand GS, Hughes CA, Jones JM, Taylor SS, Komives EA. PMID: 12381327.
View in:
PubMed Mentions:
31 Fields:
Translation:
Cells
-
Methods for studying transmembrane peptides in bicelles: consequences of hydrophobic mismatch and peptide sequence. J Magn Reson. 2002 Sep-Oct; 158(1-2):149-56.
Whiles JA, Glover KJ, Vold RR, Komives EA. PMID: 12419680.
View in:
PubMed Mentions:
13 Fields:
-
Epitope mapping of a monoclonal antibody against human thrombin by H/D-exchange mass spectrometry reveals selection of a diverse sequence in a highly conserved protein. Protein Sci. 2002 Jun; 11(6):1300-8.
Baerga-Ortiz A, Hughes CA, Mandell JG, Komives EA. PMID: 12021429; PMCID: PMC2373625.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
-
Conformational dimorphism and transmembrane orientation of prion protein residues 110-136 in bicelles. Biochemistry. 2001 Nov 06; 40(44):13137-42.
Glover KJ, Whiles JA, Wood MJ, Melacini G, Komives EA, Vold RR. PMID: 11683621.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Structural evaluation of phospholipid bicelles for solution-state studies of membrane-associated biomolecules. Biophys J. 2001 Oct; 81(4):2163-71.
Glover KJ, Whiles JA, Wu G, Yu N, Deems R, Struppe JO, Stark RE, Komives EA, Vold RR. PMID: 11566787; PMCID: PMC1301688.
View in:
PubMed Mentions:
72 Fields:
Translation:
Cells
-
Phosphorylation causes subtle changes in solvent accessibility at the interdomain interface of methylesterase CheB. J Mol Biol. 2001 Apr 06; 307(4):967-76.
Hughes CA, Mandell JG, Anand GS, Stock AM, Komives EA. PMID: 11286548.
View in:
PubMed Mentions:
20 Fields:
Translation:
Cells
-
Solvent accessibility of the thrombin-thrombomodulin interface. J Mol Biol. 2001 Feb 23; 306(3):575-89.
Mandell JG, Baerga-Ortiz A, Akashi S, Takio K, Komives EA. PMID: 11178915.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
-
Orientation and effects of mastoparan X on phospholipid bicelles. Biophys J. 2001 Jan; 80(1):280-93.
Whiles JA, Brasseur R, Glover KJ, Melacini G, Komives EA, Vold RR. PMID: 11159401; PMCID: PMC1301232.
View in:
PubMed Mentions:
26 Fields:
Translation:
Cells
-
Disulfide bond plasticity in epidermal growth factor. Proteins. 2000 Jul 01; 40(1):168-74.
Sampoli Benitez BA, Komives EA. PMID: 10813841.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Solution structure of the smallest cofactor-active fragment of thrombomodulin. Nat Struct Biol. 2000 Mar; 7(3):200-4.
Wood MJ, Sampoli Benitez BA, Komives EA. PMID: 10700277.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Electrostatic dependence of the thrombin-thrombomodulin interaction. J Mol Biol. 2000 Feb 18; 296(2):651-8.
Baerga-Ortiz A, Rezaie AR, Komives EA. PMID: 10669614.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
-
Acidic phospholipid bicelles: a versatile model membrane system. Biophys J. 2000 Jan; 78(1):281-9.
Struppe J, Whiles JA, Vold RR. PMID: 10620292; PMCID: PMC1300636.
View in:
PubMed Mentions:
29 Fields:
Translation:
Cells
-
Preparation of insoluble transmembrane peptides: glycophorin-A, prion (110-137), and FGFR (368-397). Anal Biochem. 1999 Aug 01; 272(2):270-4.
Glover KJ, Martini PM, Vold RR, Komives EA. PMID: 10415099.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
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The role of water in the catalytic efficiency of triosephosphate isomerase. Biochemistry. 1999 Apr 06; 38(14):4389-97.
Zhang Z, Komives EA, Sugio S, Blacklow SC, Narayana N, Xuong NH, Stock AM, Petsko GA, Ringe D. PMID: 10194358.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Mechanism of thrombin clearance by human astrocytoma cells. J Neurochem. 1999 Mar; 72(3):980-7.
Mentz S, de Lacalle S, Baerga-Ortiz A, Knauer MF, Knauer DJ, Komives EA. PMID: 10037469.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Production of large quantities of isotopically labeled protein in Pichia pastoris by fermentation. J Biomol NMR. 1999 Feb; 13(2):149-59.
Wood MJ, Komives EA. PMID: 10070756.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Identification of protein-protein interfaces by decreased amide proton solvent accessibility. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14705-10.
Mandell JG, Falick AM, Komives EA. PMID: 9843953; PMCID: PMC24513.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Characterization of the extracellular ligand-binding domain of the type II activin receptor. Biochemistry. 1998 Nov 24; 37(47):16711-8.
Greenwald J, Le V, Corrigan A, Fischer W, Komives E, Vale W, Choe S. PMID: 9843440.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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2H NMR studies of a myristoylated peptide in neutral and acidic phospholipid bicelles. Biochemistry. 1998 Nov 03; 37(44):15523-7.
Struppe J, Komives EA, Taylor SS, Vold RR. PMID: 9799515.
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PubMed Mentions:
20 Fields:
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Measurement of amide hydrogen exchange by MALDI-TOF mass spectrometry. Anal Chem. 1998 Oct 01; 70(19):3987-95.
Mandell JG, Falick AM, Komives EA. PMID: 9784743.
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PubMed Mentions:
64 Fields:
Translation:
Cells
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Generation of protease-deficient strains and their use in heterologous protein expression. Methods Mol Biol. 1998; 103:81-94.
Gleeson MA, White CE, Meininger DP, Komives EA. PMID: 9680635.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Structure of the fifth EGF-like domain of thrombomodulin: An EGF-like domain with a novel disulfide-bonding pattern. J Mol Biol. 1997 Nov 07; 273(4):913-26.
Sampoli Benitez BA, Hunter MJ, Meininger DP, Komives EA. PMID: 9367781.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Energetics of thrombin-thrombomodulin interaction. Biochemistry. 1997 Jun 03; 36(22):6674-81.
Vindigni A, White CE, Komives EA, Di Cera E. PMID: 9184147.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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The structural basis for pseudoreversion of the H95N lesion by the secondary S96P mutation in triosephosphate isomerase. Biochemistry. 1996 Dec 03; 35(48):15474-84.
Komives EA, Lougheed JC, Zhang Z, Sugio S, Narayana N, Xuong NH, Petsko GA, Ringe D. PMID: 8952501.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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The fifth epidermal growth factor-like domain of thrombomodulin does not have an epidermal growth factor-like disulfide bonding pattern. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10177-82.
White CE, Hunter MJ, Meininger DP, Garrod S, Komives EA. PMID: 8816772; PMCID: PMC38357.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin. Protein Sci. 1996 Feb; 5(2):195-203.
Hrabal R, Komives EA, Ni F. PMID: 8745396; PMCID: PMC2143349.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Large-scale expression, purification and characterization of small fragments of thrombomodulin: the roles of the sixth domain and of methionine 388. Protein Eng. 1995 Nov; 8(11):1177-87.
White CE, Hunter MJ, Meininger DP, White LR, Komives EA. PMID: 8819984.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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The structural basis for pseudoreversion of the E165D lesion by the secondary S96P mutation in triosephosphate isomerase depends on the positions of active site water molecules. Biochemistry. 1995 Oct 17; 34(41):13612-21.
Komives EA, Lougheed JC, Liu K, Sugio S, Zhang Z, Petsko GA, Ringe D. PMID: 7577950.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Thrombin-binding affinities of different disulfide-bonded isomers of the fifth EGF-like domain of thrombomodulin. Protein Sci. 1995 Oct; 4(10):2129-37.
Hunter MJ, Komives EA. PMID: 8535250; PMCID: PMC2142985.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin. Protein Sci. 1995 Sep; 4(9):1683-95.
Meininger DP, Hunter MJ, Komives EA. PMID: 8528067; PMCID: PMC2143218.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Deprotection of S-acetamidomethyl cysteine-containing peptides by silver trifluoromethanesulfonate avoids the oxidation of methionines. Anal Biochem. 1995 Jun 10; 228(1):173-7.
Hunter MJ, Komives EA. PMID: 8572278.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Thrombin inhibition by cyclic peptides from thrombomodulin. Protein Sci. 1995 Apr; 4(4):773-80.
Lougheed JC, Bowman CL, Meininger DP, Komives EA. PMID: 7613475; PMCID: PMC2143091.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects. Biochemistry. 1994 Nov 22; 33(46):13553-60.
Srinivasan J, Hu S, Hrabal R, Zhu Y, Komives EA, Ni F. PMID: 7947766.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Expression of highly disulfide-bonded proteins in Pichia pastoris. Structure. 1994 Nov 15; 2(11):1003-5.
White CE, Kempi NM, Komives EA. PMID: 7881900.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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The precursor of the Streptomyces R61 DD-peptidase containing a C-terminal extension is inactive. FEBS Lett. 1994 Aug 29; 351(1):49-52.
Fanuel L, Granier B, Wilkin JM, Bellefroid-Bourguignon C, Joris B, Knowles J, Komives E, Van Beeumen J, Ghuysen JM, Frère JM. PMID: 8076692.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Triosephosphate isomerase requires a positively charged active site: the role of lysine-12. Biochemistry. 1994 Mar 15; 33(10):2809-14.
Lodi PJ, Chang LC, Knowles JR, Komives EA. PMID: 8130193.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Crystal structure of the K12M/G15A triosephosphate isomerase double mutant and electrostatic analysis of the active site. Biochemistry. 1994 Mar 15; 33(10):2815-23.
Joseph-McCarthy D, Lolis E, Komives EA, Petsko GA. PMID: 8130194.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Crystal structure of the mutant yeast triosephosphate isomerase in which the catalytic base glutamic acid 165 is changed to aspartic acid. Biochemistry. 1994 Mar 15; 33(10):2824-9.
Joseph-McCarthy D, Rost LE, Komives EA, Petsko GA. PMID: 7907502.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution. Biochemistry. 1994 Mar 15; 33(10):2830-7.
Zhang Z, Sugio S, Komives EA, Liu KD, Knowles JR, Petsko GA, Ringe D. PMID: 8130195.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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cDNA sequence of rabbit tissue factor pathway inhibitor. Nucleic Acids Res. 1992 Jul 11; 20(13):3548.
Warn-Cramer BJ, Broze GJ, Komives EA. PMID: 1630940; PMCID: PMC312531.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95. Biochemistry. 1991 Mar 26; 30(12):3011-9.
Komives EA, Chang LC, Lolis E, Tilton RF, Petsko GA, Knowles JR. PMID: 2007138.
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PubMed Mentions:
36 Fields:
Translation:
Cells
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Mechanism of oxidation of pi bonds by cytochrome P-450. Electronic requirements of the transition state in the turnover of phenylacetylenes. J Biol Chem. 1987 Jul 15; 262(20):9793-802.
Komives EA, Ortiz de Montellano PR. PMID: 3597438.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Killing and mutation of human lymphoblast cells by aflatoxin B1: evidence for an inducible repair response. Cancer Res. 1987 Apr 15; 47(8):1993-2001.
Kaden DA, Call KM, Leong PM, Komives EA, Thilly WG. PMID: 3103909.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Branchpoint for heme alkylation and metabolite formation in the oxidation of arylacetylenes by cytochrome P-450. J Biol Chem. 1985 Mar 25; 260(6):3330-6.
Ortiz de Montellano PR, Komives EA. PMID: 3972828.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Mutation of xeroderma pigmentosum lymphoblasts by far-ultraviolet light. Mutat Res. 1984 Aug; 128(1):47-57.
DeLuca JG, Kaden DA, Komives EA, Thilly WG. PMID: 6472306.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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The applicant interview as a predictor of resident performance. J Med Educ. 1984 May; 59(5):425-6.
Komives E, Weiss ST, Rosa RM. PMID: 6716433.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Mutation of human lymphoblasts exposed to low concentrations of chemical mutagens for long periods of time. Mutat Res. 1983 Mar; 108(1-3):417-36.
Penman BW, Crespi CL, Komives EA, Liber HL, Thilly WG. PMID: 6403847.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells