Elizabeth Komives

Title(s)Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Biophysics Training Grant at UC San Diego
    NIH T32GM139795Jul 1, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Acquisition of an Orbitrap Elite with ETD
    NIH S10OD021724Apr 15, 2016 - Apr 14, 2017
    Role: Principal Investigator
    Functional Dynamics of Thrombin
    NIH R01HL127041Jan 15, 2016 - Dec 31, 2020
    Role: Principal Investigator
    Synapt G2-S System with HXMS Automation
    NIH S10OD016234Sep 1, 2013 - Aug 31, 2014
    Role: Principal Investigator
    2D Nano-flow Mass Spectrometry System
    NIH S10RR022420Jul 1, 2006 - Jun 30, 2007
    Role: Principal Investigator
    IkB/NF-kB Recognition in Silico, In Vitro and In Vivo
    NIH P01GM071862Apr 7, 2006 - Feb 28, 2018
    Role: Principal Investigator
    Acquisition of an MALDI TOF-TOF Mass Spectrometer
    NIH S10RR019897Jun 1, 2005 - May 31, 2006
    Role: Principal Investigator
    Directed Proteomics of Alzheimer's Related Proteins
    NIH R01AG025343Sep 30, 2004 - Aug 31, 2009
    Role: Principal Investigator
    The Thrombin-Thrombomodulin Interaction
    NIH R01HL070999Jul 1, 2002 - Feb 28, 2014
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    BIOPHYSICAL STUDIES OF LRP LIGANDS INTERACTIONS
    NIH R01AG017992Apr 1, 2000 - Mar 31, 2005
    Role: Principal Investigator
    AQUISITION OF A MALDI TOF DE STR MASS SPECTROMETER
    NIH S10RR013800Apr 15, 1999 - Apr 14, 2000
    Role: Principal Investigator
    NMR STUDIES OF MEMBRANE ASSOCIATED PEPTIDES AND PROTEINS
    NIH R01GM054034May 1, 1997 - Apr 30, 2001
    Role: Principal Investigator
    BIOPHYSICAL STUDIES OF THROMBOMODULIN EGF DOMAINS
    NIH R01HL047463Feb 1, 1992 - Aug 31, 2002
    Role: Principal Investigator
    BIOPHYSICAL STUDIES OF THROMBOMODULIN EGF DOMAINS
    NIH R29HL047463Feb 1, 1992 - Sep 29, 1996
    Role: Principal Investigator
    UNIVERSITY OF CALIFORNIA, SAN DIEGO MBRS PROGRAM
    NIH S06GM047165Sep 20, 1991 - Apr 30, 2000
    Role: Co-Investigator
    MOLECULAR BIOPHYSICS TRAINING PROGRAM
    NIH T32GM008326Jul 1, 1989 - Jun 30, 2021
    Role: Principal Investigator
    MECHANISM OF 3-DEOXYHEPTULOSONATE-7-PHOSPHATE SYNTHASE
    NIH F32GM011545Mar 16, 1987
    Role: Principal Investigator
    National Biomedical NMR Resource at Madison
    NIH P41RR002301Jul 1, 1985 - Feb 28, 2015
    Role: Co-Investigator
    HEMOGLOBIN and BLOOD PROTEIN CHEMISTRY
    NIH T32DK007233Jul 1, 1976 - Aug 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Allosteric couplings upon binding of RfaH to transcription elongation complexes. Nucleic Acids Res. 2022 Jun 07. Molina JA, Galaz-Davison P, Komives EA, Artsimovitch I, Ramírez-Sarmiento CA. PMID: 35670666.
      View in: PubMed   Mentions:
    2. Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release. Elife. 2022 05 31; 11. Bibel B, Elkayam E, Silletti S, Komives EA, Joshua-Tor L. PMID: 35638597.
      View in: PubMed   Mentions:
    3. Dimer dissociation is a key energetic event in the fold-switch pathway of KaiB. Biophys J. 2022 03 15; 121(6):943-955. Rivera M, Galaz-Davison P, Retamal-Farfán I, Komives EA, Ramírez-Sarmiento CA. PMID: 35151633; PMCID: PMC8943816.
      View in: PubMed   Mentions:
    4. How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen. Biochemistry. 2022 01 18; 61(2):77-84. Peacock RB, McGrann T, Zaragoza S, Komives EA. PMID: 34978431.
      View in: PubMed   Mentions:
    5. Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation. Nucleic Acids Res. 2021 11 08; 49(19):11211-11223. Chen W, Lu W, Wolynes PG, Komives EA. PMID: 34614173; PMCID: PMC8565325.
      View in: PubMed   Mentions:    Fields:    
    6. Achieving a realistic native protein ensemble by HDX-MS and computational modeling. Biophys J. 2021 12 07; 120(23):5139-5140. Komives EA. PMID: 34742401; PMCID: PMC8715172.
      View in: PubMed   Mentions:
    7. Development of a Rapid and Sensitive CasRx-Based Diagnostic Assay for SARS-CoV-2. ACS Sens. 2021 11 26; 6(11):3957-3966. Brogan DJ, Chaverra-Rodriguez D, Lin CP, Smidler AL, Yang T, Alcantara LM, Antoshechkin I, Liu J, Raban RR, Belda-Ferre P, Knight R, Komives EA, Akbari OS. PMID: 34714054; PMCID: PMC8577378.
      View in: PubMed   Mentions:
    8. Open, engage, bind, translocate: The multi-level dynamics of bacterial protein translocation. Structure. 2021 08 05; 29(8):781-782. Chen W, Komives EA. PMID: 34358463.
      View in: PubMed   Mentions:    Fields:    
    9. Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin. Biochemistry. 2021 11 23; 60(46):3441-3448. Peacock RB, Komives EA. PMID: 34159782.
      View in: PubMed   Mentions:    Fields:    
    10. Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Schmidt SH, Weng JH, Aoto PC, Boassa D, Mathea S, Silletti S, Hu J, Wallbott M, Komives EA, Knapp S, Herberg FW, Taylor SS. PMID: 34088839; PMCID: PMC8201809.
      View in: PubMed   Mentions: 1     Fields:    
    11. Transcription factor NF-κB unravels nucleosomes. Biochim Biophys Acta Gen Subj. 2021 09; 1865(9):129934. Stormberg T, Filliaux S, Baughman HER, Komives EA, Lyubchenko YL. PMID: 34029641; PMCID: PMC8277743.
      View in: PubMed   Mentions:    Fields:    
    12. Serine protease dynamics revealed by NMR analysis of the thrombin-thrombomodulin complex. Sci Rep. 2021 04 30; 11(1):9354. Peacock RB, McGrann T, Tonelli M, Komives EA. PMID: 33931701; PMCID: PMC8087772.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability. FEBS J. 2021 07; 288(13):4000-4023. Hoffmeister H, Fuchs A, Komives E, Groebner-Ferreira R, Strobl L, Nazet J, Heizinger L, Merkl R, Dove S, Längst G. PMID: 33403747.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases. Mol Cell Proteomics. 2021; 20:100019. Lumpkin RJ, Ahmad AS, Blake R, Condon CJ, Komives EA. PMID: 33268465; PMCID: PMC7950132.
      View in: PubMed   Mentions: 1     Fields:    
    15. Surveying biomolecular frustration at atomic resolution. Nat Commun. 2020 11 23; 11(1):5944. Chen M, Chen X, Schafer NP, Clementi C, Komives EA, Ferreiro DU, Wolynes PG. PMID: 33230150; PMCID: PMC7683549.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    16. A Sensitive, Rapid, and Portable CasRx-based Diagnostic Assay for SARS-CoV-2. medRxiv. 2020 Oct 20. Brogan DJ, Chaverra-Rodriguez D, Lin CP, Smidler AL, Yang T, Alcantara LM, Antoshechkin I, Liu J, Raban RR, Belda-Ferre P, Knight R, Komives EA, Akbari OS. PMID: 33106816; PMCID: PMC7587836.
      View in: PubMed   Mentions:
    17. Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping. J Mol Biol. 2020 09 04; 432(19):5411-5429. Medina E, Villalobos P, Hamilton GL, Komives EA, Sanabria H, Ramírez-Sarmiento CA, Babul J. PMID: 32735805; PMCID: PMC7663421.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nat Commun. 2020 06 08; 11(1):2866. Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. PMID: 32513959; PMCID: PMC7280518.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Complementarity of Hydrogen/Deuterium Exchange Mass Spectrometry and Cryo-Electron Microscopy. Trends Biochem Sci. 2020 10; 45(10):906-918. Engen JR, Komives EA. PMID: 32487353; PMCID: PMC7502526.
      View in: PubMed   Mentions: 1     Fields:    
    20. Differential Local Stability Governs the Metamorphic Fold Switch of Bacterial Virulence Factor RfaH. Biophys J. 2020 01 07; 118(1):96-104. Galaz-Davison P, Molina JA, Silletti S, Komives EA, Knauer SH, Artsimovitch I, Ramírez-Sarmiento CA. PMID: 31810657; PMCID: PMC6950767.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    21. Decoupling a tandem-repeat protein: Impact of multiple loop insertions on a modular scaffold. Sci Rep. 2019 10 28; 9(1):15439. Perez-Riba A, Komives E, Main ERG, Itzhaki LS. PMID: 31659184; PMCID: PMC6817815.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    22. Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. Sci Rep. 2019 10 22; 9(1):15092. Kopcho N, Chang G, Komives EA. PMID: 31641149; PMCID: PMC6805939.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. DECA, A Comprehensive, Automatic Post-processing Program for HDX-MS Data. Mol Cell Proteomics. 2019 12; 18(12):2516-2523. Lumpkin RJ, Komives EA. PMID: 31594786; PMCID: PMC6885705.
      View in: PubMed   Mentions: 7     Fields:    
    24. Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16394-16403. Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I. PMID: 31363053; PMCID: PMC6697900.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. Cryo-EM structure of OSCA1.2 from Oryza sativa elucidates the mechanical basis of potential membrane hyperosmolality gating. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14309-14318. Maity K, Heumann JM, McGrath AP, Kopcho NJ, Hsu PK, Lee CW, Mapes JH, Garza D, Krishnan S, Morgan GP, Hendargo KJ, Klose T, Rees SD, Medrano-Soto A, Saier MH, Piñeros M, Komives EA, Schroeder JI, Chang G, Stowell MHB. PMID: 31227607; PMCID: PMC6628804.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. Exclusivity and Compensation in NFκB Dimer Distributions and IκB Inhibition. Biochemistry. 2019 05 28; 58(21):2555-2563. Ramsey KM, Chen W, Marion JD, Bergqvist S, Komives EA. PMID: 31033276; PMCID: PMC6642826.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    27. Accurate Prediction of Amide Exchange in the Fast Limit Reveals Thrombin Allostery. Biophys J. 2019 01 08; 116(1):49-56. Markwick PRL, Peacock RB, Komives EA. PMID: 30558884; PMCID: PMC6342732.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. Deciphering and engineering chromodomain-methyllysine peptide recognition. Sci Adv. 2018 11; 4(11):eaau1447. Hard R, Li N, He W, Ross B, Mo GCH, Peng Q, Stein RSL, Komives E, Wang Y, Zhang J, Wang W. PMID: 30417094; PMCID: PMC6221542.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    29. Calcium sensing by the STIM1 ER-luminal domain. Nat Commun. 2018 10 31; 9(1):4536. Gudlur A, Zeraik AE, Hirve N, Rajanikanth V, Bobkov AA, Ma G, Zheng S, Wang Y, Zhou Y, Komives EA, Hogan PG. PMID: 30382093; PMCID: PMC6208404.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    30. Prediction of the presence of a seventh ankyrin repeat in IκBε from homology modeling combined with hydrogen-deuterium exchange mass spectrometry (HDX-MS). Protein Sci. 2018 09; 27(9):1624-1635. Ramsey KM, Narang D, Komives EA. PMID: 30133030; PMCID: PMC6194264.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation. Nat Struct Mol Biol. 2018 08; 25(8):687-697. Rahnamoun H, Lee J, Sun Z, Lu H, Ramsey KM, Komives EA, Lauberth SM. PMID: 30076409; PMCID: PMC6859054.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    32. Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin. Biochemistry. 2018 05 08; 57(18):2694-2703. Peacock RB, Davis JR, Markwick PRL, Komives EA. PMID: 29634247; PMCID: PMC5940494.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    33. Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions. Methods. 2018 07 15; 144:43-52. Ramirez-Sarmiento CA, Komives EA. PMID: 29627358; PMCID: PMC6051914.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. RelA-Containing NFκB Dimers Have Strikingly Different DNA-Binding Cavities in the Absence of DNA. J Mol Biol. 2018 05 11; 430(10):1510-1520. Narang D, Chen W, Ricci CG, Komives EA. PMID: 29625198; PMCID: PMC5951767.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    35. Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation. PLoS One. 2018; 13(2):e0192661. Kromann-Hansen T, Lange EL, Lund IK, Høyer-Hansen G, Andreasen PA, Komives EA. PMID: 29420634; PMCID: PMC5805342.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    36. Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. Nucleic Acids Res. 2018 01 09; 46(1):279-292. West AMV, Komives EA, Corbett KD. PMID: 29186573; PMCID: PMC5758881.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. Resolving the NFκB Heterodimer Binding Paradox: Strain and Frustration Guide the Binding of Dimeric Transcription Factors. J Am Chem Soc. 2017 12 27; 139(51):18558-18566. Potoyan DA, Bueno C, Zheng W, Komives EA, Wolynes PG. PMID: 29183131; PMCID: PMC5803749.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    38. Structural Basis for Shelterin Bridge Assembly. Mol Cell. 2017 Nov 16; 68(4):698-714.e5. Kim JK, Liu J, Hu X, Yu C, Roskamp K, Sankaran B, Huang L, Komives EA, Qiao F. PMID: 29149597; PMCID: PMC5698806.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    39. Frustration, function and folding. Curr Opin Struct Biol. 2018 02; 48:68-73. Ferreiro DU, Komives EA, Wolynes PG. PMID: 29101782; PMCID: PMC6005193.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    40. Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun. 2017 10 27; 8(1):1171. Lumpkin RJ, Gu H, Zhu Y, Leonard M, Ahmad AS, Clauser KR, Meyer JG, Bennett EJ, Komives EA. PMID: 29079793; PMCID: PMC5660086.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    41. Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation. Nat Commun. 2017 10 03; 8(1):781. Wong JJW, Young TA, Zhang J, Liu S, Leser GP, Komives EA, Lamb RA, Zhou ZH, Salafsky J, Jardetzky TS. PMID: 28974687; PMCID: PMC5626764.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    42. Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep. 2017 06 13; 7(1):3385. Kromann-Hansen T, Louise Lange E, Peter Sørensen H, Hassanzadeh-Ghassabeh G, Huang M, Jensen JK, Muyldermans S, Declerck PJ, Komives EA, Andreasen PA. PMID: 28611361; PMCID: PMC5469797.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    43. Unusual dimerization of a BcCsp mutant leads to reduced conformational dynamics. FEBS J. 2017 06; 284(12):1882-1896. Carvajal AI, Vallejos G, Komives EA, Castro-Fernández V, Leonardo DA, Garratt RC, Ramírez-Sarmiento CA, Babul J. PMID: 28457014; PMCID: PMC5505725.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    44. DNA and IκBα Both Induce Long-Range Conformational Changes in NFκB. J Mol Biol. 2017 04 07; 429(7):999-1008. Ramsey KM, Dembinski HE, Chen W, Ricci CG, Komives EA. PMID: 28249778; PMCID: PMC5389416.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    45. Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):1916-1921. Dembinski HE, Wismer K, Vargas JD, Suryawanshi GW, Kern N, Kroon G, Dyson HJ, Hoffmann A, Komives EA. PMID: 28167786; PMCID: PMC5338396.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    46. NMR reveals a dynamic allosteric pathway in thrombin. Sci Rep. 2017 01 06; 7:39575. Handley LD, Fuglestad B, Stearns K, Tonelli M, Fenwick RB, Markwick PR, Komives EA. PMID: 28059082; PMCID: PMC5216386.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    47. Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer. Structure. 2016 08 02; 24(8):1248-1256. Schiffer JM, Malmstrom RD, Parnell J, Ramirez-Sarmiento C, Reyes J, Amaro RE, Komives EA. PMID: 27396830; PMCID: PMC4972691.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    48. Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1. Biophys J. 2016 06 07; 110(11):2349-2360. Medina E, Córdova C, Villalobos P, Reyes J, Komives EA, Ramírez-Sarmiento CA, Babul J. PMID: 27276253; PMCID: PMC4922571.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    49. Structural characterization of the ternary complex that mediates termination of NF-κB signaling by IκBα. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6212-7. Mukherjee SP, Quintas PO, McNulty R, Komives EA, Dyson HJ. PMID: 27185953; PMCID: PMC4896678.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    50. PEST Control of Molecular Stripping of NFκB from DNA Transcription Sites. J Phys Chem B. 2016 08 25; 120(33):8532-8. Potoyan DA, Zheng W, Ferreiro DU, Wolynes PG, Komives EA. PMID: 27098223; PMCID: PMC5389414.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    51. Binding of NFκB Appears to Twist the Ankyrin Repeat Domain of IκBα. Biophys J. 2016 Feb 23; 110(4):887-95. Trelle MB, Ramsey KM, Lee TC, Zheng W, Lamboy J, Wolynes PG, Deniz A, Komives EA. PMID: 26910425; PMCID: PMC4776026.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    52. Molecular stripping in the NF-κB/IκB/DNA genetic regulatory network. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):110-5. Potoyan DA, Zheng W, Komives EA, Wolynes PG. PMID: 26699500; PMCID: PMC4711861.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    53. Thrombomodulin Binding Selects the Catalytically Active Form of Thrombin. Biochemistry. 2015 Nov 03; 54(43):6650-8. Handley LD, Treuheit NA, Venkatesh VJ, Komives EA. PMID: 26468766; PMCID: PMC4697735.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    54. The folding unit of phosphofructokinase-2 as defined by the biophysical properties of a monomeric mutant. Biophys J. 2015 May 05; 108(9):2350-61. Ramírez-Sarmiento CA, Baez M, Zamora RA, Balasubramaniam D, Babul J, Komives EA, Guixé V. PMID: 25954892; PMCID: PMC4423062.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    55. Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. Arch Toxicol. 2016 Mar; 90(3):603-16. Mangas I, Taylor P, Vilanova E, Estévez J, França TC, Komives E, Radic Z. PMID: 25743373; PMCID: PMC4833118.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    56. How the ankyrin and SOCS box protein, ASB9, binds to creatine kinase. Biochemistry. 2015 Mar 03; 54(8):1673-80. Balasubramaniam D, Schiffer J, Parnell J, Mir SP, Amaro RE, Komives EA. PMID: 25654263; PMCID: PMC4348336.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    57. Frustration in biomolecules. Q Rev Biophys. 2014 Nov; 47(4):285-363. Ferreiro DU, Komives EA, Wolynes PG. PMID: 25225856; PMCID: PMC4256721.
      View in: PubMed   Mentions: 76     Fields:    Translation:Humans
    58. Trypsinogen activation as observed in accelerated molecular dynamics simulations. Protein Sci. 2014 Nov; 23(11):1550-8. Boechi L, Pierce L, Komives EA, McCammon JA. PMID: 25131668; PMCID: PMC4241106.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    59. Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA. Biochim Biophys Acta. 2014 Sep; 1840(9):2851-61. Perera VR, Newton GL, Parnell JM, Komives EA, Pogliano K. PMID: 24821014; PMCID: PMC4802972.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    60. The phylogenetics of dynamics in DNA clamp proteins. Structure. 2014 Apr 08; 22(4):511-2. Balasubramaniam D, Komives EA. PMID: 24717558.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    61. Predicted disorder-to-order transition mutations in IκBα disrupt function. Phys Chem Chem Phys. 2014 Apr 14; 16(14):6480-5. Dembinski H, Wismer K, Balasubramaniam D, Gonzalez HA, Alverdi V, Iakoucheva LM, Komives EA. PMID: 24605363; PMCID: PMC4040282.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    62. Expanding proteome coverage with orthogonal-specificity α-lytic proteases. Mol Cell Proteomics. 2014 Mar; 13(3):823-35. Meyer JG, Kim S, Maltby DA, Ghassemian M, Bandeira N, Komives EA. PMID: 24425750; PMCID: PMC3945911.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    63. Direct observation of a transient ternary complex during IκBα-mediated dissociation of NF-κB from DNA. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):225-30. Alverdi V, Hetrick B, Joseph S, Komives EA. PMID: 24367071; PMCID: PMC3890772.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    64. Identification of methyllysine peptides binding to chromobox protein homolog 6 chromodomain in the human proteome. Mol Cell Proteomics. 2013 Oct; 12(10):2750-60. Li N, Stein RS, He W, Komives E, Wang W. PMID: 23842000; PMCID: PMC3790288.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    65. Correlated motions and residual frustration in thrombin. J Phys Chem B. 2013 Oct 24; 117(42):12857-63. Fuglestad B, Gasper PM, McCammon JA, Markwick PR, Komives EA. PMID: 23621631; PMCID: PMC3808083.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    66. Observation of solvent penetration during cold denaturation of E. coli phosphofructokinase-2. Biophys J. 2013 May 21; 104(10):2254-63. Ramírez-Sarmiento CA, Baez M, Wilson CA, Babul J, Komives EA, Guixé V. PMID: 23708365; PMCID: PMC3660636.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    67. Single-molecule FRET reveals the native-state dynamics of the IκBα ankyrin repeat domain. J Mol Biol. 2013 Jul 24; 425(14):2578-90. Lamboy JA, Kim H, Dembinski H, Ha T, Komives EA. PMID: 23619335; PMCID: PMC3758917.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    68. Recognition of methylated peptides by Drosophila melanogaster polycomb chromodomain. J Proteome Res. 2013 Mar 01; 12(3):1467-77. Stein RS, Li N, He W, Komives E, Wang W. PMID: 23320494; PMCID: PMC4258113.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    69. Long-range effects and functional consequences of stabilizing mutations in the ankyrin repeat domain of IκBα. J Mol Biol. 2013 Mar 11; 425(5):902-13. Cervantes CF, Handley LD, Sue SC, Dyson HJ, Komives EA. PMID: 23274114; PMCID: PMC3744861.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    70. Discrete kinetic models from funneled energy landscape simulations. PLoS One. 2012; 7(12):e50635. Schafer NP, Hoffman RM, Burger A, Craig PO, Komives EA, Wolynes PG. PMID: 23251375; PMCID: PMC3520928.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    71. Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21216-22. Gasper PM, Fuglestad B, Komives EA, Markwick PR, McCammon JA. PMID: 23197839; PMCID: PMC3535651.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    72. Hydrogen-exchange mass spectrometry for the study of intrinsic disorder in proteins. Biochim Biophys Acta. 2013 Jun; 1834(6):1202-9. Balasubramaniam D, Komives EA. PMID: 23099262; PMCID: PMC3600394.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    73. The dynamic structure of thrombin in solution. Biophys J. 2012 Jul 03; 103(1):79-88. Fuglestad B, Gasper PM, Tonelli M, McCammon JA, Markwick PR, Komives EA. PMID: 22828334; PMCID: PMC3388214.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    74. Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Toxicol Sci. 2012 Sep; 129(1):200-12. Guo L, Ghassemian M, Komives EA, Russell P. PMID: 22610605; PMCID: PMC3713068.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    75. Role of disorder in IκB-NFκB interaction. IUBMB Life. 2012 Jun; 64(6):499-505. Dyson HJ, Komives EA. PMID: 22573609; PMCID: PMC3575514.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    76. Feedback inhibition by thiols outranks glutathione depletion: a luciferase-based screen reveals glutathione-deficient γ-ECS and glutathione synthetase mutants impaired in cadmium-induced sulfate assimilation. Plant J. 2012 Jun; 70(5):783-95. Jobe TO, Sung DY, Akmakjian G, Pham A, Komives EA, Mendoza-Cózatl DG, Schroeder JI. PMID: 22283708; PMCID: PMC4688143.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    77. Consequences of fuzziness in the NFκB/IκBα interaction. Adv Exp Med Biol. 2012; 725:74-85. Komives EA. PMID: 22399319; PMCID: PMC3603378.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    78. The structure, dynamics, and binding of the LA45 module pair of the low-density lipoprotein receptor suggest an important role for LA4 in ligand release. Biochemistry. 2011 Dec 27; 50(51):11001-8. Guttman M, Komives EA. PMID: 22091758; PMCID: PMC3263374.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    79. Prediction of native-state hydrogen exchange from perfectly funneled energy landscapes. J Am Chem Soc. 2011 Nov 02; 133(43):17463-72. Craig PO, Lätzer J, Weinkam P, Hoffman RM, Ferreiro DU, Komives EA, Wolynes PG. PMID: 21913704; PMCID: PMC3203634.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    80. Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein. Biochemistry. 2011 Jul 19; 50(28):6208-16. Mulvihill MM, Guttman M, Komives EA. PMID: 21650223; PMCID: PMC3139566.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    81. Visualization of the nanospring dynamics of the IkappaBalpha ankyrin repeat domain in real time. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10178-83. Lamboy JA, Kim H, Lee KS, Ha T, Komives EA. PMID: 21628581; PMCID: PMC3121830.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    82. Thermodynamic compensation upon binding to exosite 1 and the active site of thrombin. Biochemistry. 2011 May 31; 50(21):4590-6. Treuheit NA, Beach MA, Komives EA. PMID: 21526769; PMCID: PMC3107735.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    83. Folding kinetics of the cooperatively folded subdomain of the IκBα ankyrin repeat domain. J Mol Biol. 2011 Apr 22; 408(1):163-76. DeVries I, Ferreiro DU, Sánchez IE, Komives EA. PMID: 21329696; PMCID: PMC3081522.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    84. On the role of frustration in the energy landscapes of allosteric proteins. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3499-503. Ferreiro DU, Hegler JA, Komives EA, Wolynes PG. PMID: 21273505; PMCID: PMC3048099.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    85. Detection of a ternary complex of NF-kappaB and IkappaBalpha with DNA provides insights into how IkappaBalpha removes NF-kappaB from transcription sites. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1367-72. Sue SC, Alverdi V, Komives EA, Dyson HJ. PMID: 21220295; PMCID: PMC3029698.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    86. The RelA nuclear localization signal folds upon binding to IκBα. J Mol Biol. 2011 Jan 21; 405(3):754-64. Cervantes CF, Bergqvist S, Kjaergaard M, Kroon G, Sue SC, Dyson HJ, Komives EA. PMID: 21094161; PMCID: PMC3056351.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    87. Consequences of IkappaB alpha hydroxylation by the factor inhibiting HIF (FIH). FEBS Lett. 2010 Dec 01; 584(23):4725-30. Devries IL, Hampton-Smith RJ, Mulvihill MM, Alverdi V, Peet DJ, Komives EA. PMID: 21056038; PMCID: PMC3034650.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    88. Flexible regions within I{kappa}B{alpha} create the ubiquitin-independent degradation signal. J Biol Chem. 2010 Oct 22; 285(43):32927-32936. Mathes E, Wang L, Komives E, Ghosh G. PMID: 20682784; PMCID: PMC2963393.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    89. Critical salt bridges guide capsid assembly, stability, and maturation behavior in bacteriophage HK97. Mol Cell Proteomics. 2010 Aug; 9(8):1752-63. Gertsman I, Fu CY, Huang R, Komives EA, Johnson JE. PMID: 20332083; PMCID: PMC2938056.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    90. Structure of the minimal interface between ApoE and LRP. J Mol Biol. 2010 Apr 30; 398(2):306-19. Guttman M, Prieto JH, Handel TM, Domaille PJ, Komives EA. PMID: 20303980; PMCID: PMC2880916.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    91. Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha. Biochemistry. 2010 Mar 02; 49(8):1560-7. Ferreiro DU, Komives EA. PMID: 20055496; PMCID: PMC2865148.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    92. Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E. Biochemistry. 2010 Feb 16; 49(6):1207-16. Guttman M, Prieto JH, Croy JE, Komives EA. PMID: 20030366; PMCID: PMC2821871.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    93. Enhanced conformational space sampling improves the prediction of chemical shifts in proteins. J Am Chem Soc. 2010 Feb 03; 132(4):1220-1. Markwick PR, Cervantes CF, Abel BL, Komives EA, Blackledge M, McCammon JA. PMID: 20063881; PMCID: PMC2812018.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    94. HK97 maturation studied by crystallography and H/2H exchange reveals the structural basis for exothermic particle transitions. J Mol Biol. 2010 Mar 26; 397(2):560-74. Gertsman I, Komives EA, Johnson JE. PMID: 20093122; PMCID: PMC2855905.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    95. Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19328-33. Bergqvist S, Alverdi V, Mengel B, Hoffmann A, Ghosh G, Komives EA. PMID: 19887633; PMCID: PMC2780789.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    96. Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1. Proteomics. 2009 Nov; 9(22):5016-28. Guttman M, Betts GN, Barnes H, Ghassemian M, van der Geer P, Komives EA. PMID: 19771558; PMCID: PMC2862490.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    97. Functional dynamics of the folded ankyrin repeats of I kappa B alpha revealed by nuclear magnetic resonance. Biochemistry. 2009 Aug 25; 48(33):8023-31. Cervantes CF, Markwick PR, Sue SC, McCammon JA, Dyson HJ, Komives EA. PMID: 19591507; PMCID: PMC2728578.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    98. ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis. Plant J. 2009 Sep; 59(5):802-13. Sung DY, Kim TH, Komives EA, Mendoza-Cózatl DG, Schroeder JI. PMID: 19453443; PMCID: PMC2830867.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    99. An unexpected twist in viral capsid maturation. Nature. 2009 Apr 02; 458(7238):646-50. Gertsman I, Gan L, Guttman M, Lee K, Speir JA, Duda RL, Hendrix RW, Komives EA, Johnson JE. PMID: 19204733; PMCID: PMC2765791.
      View in: PubMed   Mentions: 68     Fields:    Translation:Cells
    100. The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface. Protein Sci. 2008 Dec; 17(12):2051-8. Bergqvist S, Ghosh G, Komives EA. PMID: 18824506; PMCID: PMC2590914.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    101. Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin. Biochemistry. 2008 Oct 14; 47(41):10933-9. Koeppe JR, Beach MA, Baerga-Ortiz A, Kerns SJ, Komives EA. PMID: 18803401; PMCID: PMC2630536.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    102. Rapid mass spectrometric analysis of 15N-Leu incorporation fidelity during preparation of specifically labeled NMR samples. Protein Sci. 2008 Sep; 17(9):1636-9. Truhlar SM, Cervantes CF, Torpey JW, Kjaergaard M, Komives EA. PMID: 18567787; PMCID: PMC2525515.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    103. Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex. J Mol Biol. 2008 Jul 25; 380(5):917-31. Sue SC, Cervantes C, Komives EA, Dyson HJ. PMID: 18565540; PMCID: PMC2603615.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    104. The energy landscapes of repeat-containing proteins: topology, cooperativity, and the folding funnels of one-dimensional architectures. PLoS Comput Biol. 2008 May 16; 4(5):e1000070. Ferreiro DU, Walczak AM, Komives EA, Wolynes PG. PMID: 18483553; PMCID: PMC2366061.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    105. LRR domain folding: just put a cap on it! Structure. 2008 May; 16(5):655-7. Truhlar SM, Komives EA. PMID: 18462667.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    106. Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain. J Biol Chem. 2008 Jun 06; 283(23):15656-64. Betts GN, van der Geer P, Komives EA. PMID: 18381291; PMCID: PMC2414285.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    107. Pre-folding IkappaBalpha alters control of NF-kappaB signaling. J Mol Biol. 2008 Jun 27; 380(1):67-82. Truhlar SM, Mathes E, Cervantes CF, Ghosh G, Komives EA. PMID: 18511071; PMCID: PMC2519148.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    108. A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes. Antimicrob Agents Chemother. 2008 May; 52(5):1834-6. Huang CM, Torpey JW, Liu YT, Chen YR, Williams KE, Komives EA, Gallo RL. PMID: 18285475; PMCID: PMC2346631.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    109. Folding landscapes of ankyrin repeat proteins: experiments meet theory. Curr Opin Struct Biol. 2008 Feb; 18(1):27-34. Barrick D, Ferreiro DU, Komives EA. PMID: 18243686; PMCID: PMC2680087.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    110. Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus. A role for thiol-peptides in the long-distance transport of cadmium and the effect of cadmium on iron translocation. Plant J. 2008 Apr; 54(2):249-59. Mendoza-Cózatl DG, Butko E, Springer F, Torpey JW, Komives EA, Kehr J, Schroeder JI. PMID: 18208526; PMCID: PMC2839885.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    111. Localizing frustration in native proteins and protein assemblies. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19819-24. Ferreiro DU, Hegler JA, Komives EA, Wolynes PG. PMID: 18077414; PMCID: PMC2148382.
      View in: PubMed   Mentions: 115     Fields:    Translation:Cells
    112. Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family member. J Immunol. 2007 Oct 01; 179(7):4939-44. Wu X, Li ZF, Brooks R, Komives EA, Torpey JW, Engvall E, Gonias SL, Shelton GD. PMID: 17878394.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    113. R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. J Mol Biol. 2007 Nov 23; 374(2):487-99. Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA, Taylor SS. PMID: 17942118; PMCID: PMC3419600.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    114. The plastic landscape of repeat proteins. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7735-6. Ferreiro DU, Komives EA. PMID: 17483477; PMCID: PMC1876514.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    115. Identification of an arsenic tolerant double mutant with a thiol-mediated component and increased arsenic tolerance in phyA mutants. Plant J. 2007 Mar; 49(6):1064-75. Sung DY, Lee D, Harris H, Raab A, Feldmann J, Meharg A, Kumabe B, Komives EA, Schroeder JI. PMID: 17335514.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    116. Induced fit, folding, and recognition of the NF-kappaB-nuclear localization signals by IkappaBalpha and IkappaBbeta. J Mol Biol. 2007 Mar 16; 367(1):262-74. Lätzer J, Papoian GA, Prentiss MC, Komives EA, Wolynes PG. PMID: 17257619.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    117. Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB.DNA interaction fold upon binding to NF-kappaB. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):18951-6. Truhlar SM, Torpey JW, Komives EA. PMID: 17148610; PMCID: PMC1748158.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    118. Stabilizing IkappaBalpha by "consensus" design. J Mol Biol. 2007 Jan 26; 365(4):1201-16. Ferreiro DU, Cervantes CF, Truhlar SM, Cho SS, Wolynes PG, Komives EA. PMID: 17174335; PMCID: PMC1866275.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    119. Solvent accessibility of protein surfaces by amide H/2H exchange MALDI-TOF mass spectrometry. J Am Soc Mass Spectrom. 2006 Nov; 17(11):1490-7. Truhlar SM, Croy CH, Torpey JW, Koeppe JR, Komives EA. PMID: 16934999.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    120. Amide H/2H exchange reveals a mechanism of thrombin activation. Biochemistry. 2006 Jun 27; 45(25):7724-32. Koeppe JR, Komives EA. PMID: 16784223; PMCID: PMC2535819.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    121. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol. 2006 Jul 07; 360(2):421-34. Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. PMID: 16756995; PMCID: PMC2680085.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    122. An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis. Plant Physiol. 2006 May; 141(1):108-20. Chen A, Komives EA, Schroeder JI. PMID: 16531489; PMCID: PMC1459314.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    123. Automated extraction of backbone deuteration levels from amide H/2H mass spectrometry experiments. Protein Sci. 2006 Mar; 15(3):583-601. Hotchko M, Anand GS, Komives EA, Ten Eyck LF. PMID: 16501228; PMCID: PMC2249778.
      View in: PubMed   Mentions: 37     Fields:    
    124. Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry. J Biol Chem. 2006 Apr 28; 281(17):12170-7. Shi J, Koeppe JR, Komives EA, Taylor P. PMID: 16484218.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    125. Thrombomodulin tightens the thrombin active site loops to promote protein C activation. Biochemistry. 2005 Nov 15; 44(45):14784-91. Koeppe JR, Seitova A, Mather T, Komives EA. PMID: 16274226.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    126. The energy landscape of modular repeat proteins: topology determines folding mechanism in the ankyrin family. J Mol Biol. 2005 Dec 02; 354(3):679-92. Ferreiro DU, Cho SS, Komives EA, Wolynes PG. PMID: 16257414.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    127. Application of amide proton exchange mass spectrometry for the study of protein-protein interactions. Curr Protoc Protein Sci. 2005 Jun; Chapter 20:Unit20.9. Mandell JG, Baerga-Ortiz A, Croy CH, Falick AM, Komives EA. PMID: 18429282.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    128. Dynamics of the fragment of thrombomodulin containing the fourth and fifth epidermal growth factor-like domains correlate with function. Biochemistry. 2005 Feb 01; 44(4):1225-33. Prieto JH, Sampoli Benitez BA, Melacini G, Johnson DA, Wood MJ, Komives EA. PMID: 15667216.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    129. Structural and functional consequences of methionine oxidation in thrombomodulin. Biochim Biophys Acta. 2005 Jan 17; 1703(2):141-7. Wood MJ, Helena Prieto J, Komives EA. PMID: 15680222.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    130. Measurement of solvent accessibility at protein-protein interfaces. Methods Mol Biol. 2005; 305:65-80. Mandell JG, Baerga-Ortiz A, Falick AM, Komives EA. PMID: 15939994.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    131. Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci. 2004 Jul; 13(7):1767-77. Croy CH, Bergqvist S, Huxford T, Ghosh G, Komives EA. PMID: 15215520; PMCID: PMC2279933.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    132. Two apolipoprotein E mimetic peptides, ApoE(130-149) and ApoE(141-155)2, bind to LRP1. Biochemistry. 2004 Jun 15; 43(23):7328-35. Croy JE, Brandon T, Komives EA. PMID: 15182176.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    133. Allosteric changes in solvent accessibility observed in thrombin upon active site occupation. Biochemistry. 2004 May 11; 43(18):5246-55. Croy CH, Koeppe JR, Bergqvist S, Komives EA. PMID: 15122890.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    134. Two different proteins that compete for binding to thrombin have opposite kinetic and thermodynamic profiles. Protein Sci. 2004 Jan; 13(1):166-76. Baerga-Ortiz A, Bergqvist S, Mandell JG, Komives EA. PMID: 14691232; PMCID: PMC2286536.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    135. All three LDL receptor homology regions of the LDL receptor-related protein bind multiple ligands. Biochemistry. 2003 Nov 11; 42(44):13049-57. Croy JE, Shin WD, Knauer MF, Knauer DJ, Komives EA. PMID: 14596620.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    136. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13264-9. Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck LF, Komives EA. PMID: 14583592; PMCID: PMC263775.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    137. NMR structures reveal how oxidation inactivates thrombomodulin. Biochemistry. 2003 Oct 21; 42(41):11932-42. Wood MJ, Becvar LA, Prieto JH, Melacini G, Komives EA. PMID: 14556624.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    138. Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry. Biochemistry. 2003 Sep 23; 42(37):11083-91. Jennings LL, Malecki M, Komives EA, Taylor P. PMID: 12974645.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    139. Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation. J Mol Biol. 2002 Dec 06; 324(4):587-97. Huxford T, Mishler D, Phelps CB, Huang DB, Sengchanthalangsy LL, Reeves R, Hughes CA, Komives EA, Ghosh G. PMID: 12460563.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    140. Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. J Mol Biol. 2002 Oct 18; 323(2):377-86. Anand GS, Hughes CA, Jones JM, Taylor SS, Komives EA. PMID: 12381327.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    141. Methods for studying transmembrane peptides in bicelles: consequences of hydrophobic mismatch and peptide sequence. J Magn Reson. 2002 Sep-Oct; 158(1-2):149-56. Whiles JA, Glover KJ, Vold RR, Komives EA. PMID: 12419680.
      View in: PubMed   Mentions: 13     Fields:    
    142. Epitope mapping of a monoclonal antibody against human thrombin by H/D-exchange mass spectrometry reveals selection of a diverse sequence in a highly conserved protein. Protein Sci. 2002 Jun; 11(6):1300-8. Baerga-Ortiz A, Hughes CA, Mandell JG, Komives EA. PMID: 12021429; PMCID: PMC2373625.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    143. Conformational dimorphism and transmembrane orientation of prion protein residues 110-136 in bicelles. Biochemistry. 2001 Nov 06; 40(44):13137-42. Glover KJ, Whiles JA, Wood MJ, Melacini G, Komives EA, Vold RR. PMID: 11683621.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    144. Structural evaluation of phospholipid bicelles for solution-state studies of membrane-associated biomolecules. Biophys J. 2001 Oct; 81(4):2163-71. Glover KJ, Whiles JA, Wu G, Yu N, Deems R, Struppe JO, Stark RE, Komives EA, Vold RR. PMID: 11566787; PMCID: PMC1301688.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    145. Phosphorylation causes subtle changes in solvent accessibility at the interdomain interface of methylesterase CheB. J Mol Biol. 2001 Apr 06; 307(4):967-76. Hughes CA, Mandell JG, Anand GS, Stock AM, Komives EA. PMID: 11286548.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    146. Solvent accessibility of the thrombin-thrombomodulin interface. J Mol Biol. 2001 Feb 23; 306(3):575-89. Mandell JG, Baerga-Ortiz A, Akashi S, Takio K, Komives EA. PMID: 11178915.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    147. Orientation and effects of mastoparan X on phospholipid bicelles. Biophys J. 2001 Jan; 80(1):280-93. Whiles JA, Brasseur R, Glover KJ, Melacini G, Komives EA, Vold RR. PMID: 11159401; PMCID: PMC1301232.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    148. Disulfide bond plasticity in epidermal growth factor. Proteins. 2000 Jul 01; 40(1):168-74. Sampoli Benitez BA, Komives EA. PMID: 10813841.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    149. Solution structure of the smallest cofactor-active fragment of thrombomodulin. Nat Struct Biol. 2000 Mar; 7(3):200-4. Wood MJ, Sampoli Benitez BA, Komives EA. PMID: 10700277.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    150. Electrostatic dependence of the thrombin-thrombomodulin interaction. J Mol Biol. 2000 Feb 18; 296(2):651-8. Baerga-Ortiz A, Rezaie AR, Komives EA. PMID: 10669614.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    151. Acidic phospholipid bicelles: a versatile model membrane system. Biophys J. 2000 Jan; 78(1):281-9. Struppe J, Whiles JA, Vold RR. PMID: 10620292; PMCID: PMC1300636.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    152. Preparation of insoluble transmembrane peptides: glycophorin-A, prion (110-137), and FGFR (368-397). Anal Biochem. 1999 Aug 01; 272(2):270-4. Glover KJ, Martini PM, Vold RR, Komives EA. PMID: 10415099.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    153. The role of water in the catalytic efficiency of triosephosphate isomerase. Biochemistry. 1999 Apr 06; 38(14):4389-97. Zhang Z, Komives EA, Sugio S, Blacklow SC, Narayana N, Xuong NH, Stock AM, Petsko GA, Ringe D. PMID: 10194358.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    154. Mechanism of thrombin clearance by human astrocytoma cells. J Neurochem. 1999 Mar; 72(3):980-7. Mentz S, de Lacalle S, Baerga-Ortiz A, Knauer MF, Knauer DJ, Komives EA. PMID: 10037469.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    155. Production of large quantities of isotopically labeled protein in Pichia pastoris by fermentation. J Biomol NMR. 1999 Feb; 13(2):149-59. Wood MJ, Komives EA. PMID: 10070756.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    156. Identification of protein-protein interfaces by decreased amide proton solvent accessibility. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14705-10. Mandell JG, Falick AM, Komives EA. PMID: 9843953; PMCID: PMC24513.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    157. Characterization of the extracellular ligand-binding domain of the type II activin receptor. Biochemistry. 1998 Nov 24; 37(47):16711-8. Greenwald J, Le V, Corrigan A, Fischer W, Komives E, Vale W, Choe S. PMID: 9843440.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    158. 2H NMR studies of a myristoylated peptide in neutral and acidic phospholipid bicelles. Biochemistry. 1998 Nov 03; 37(44):15523-7. Struppe J, Komives EA, Taylor SS, Vold RR. PMID: 9799515.
      View in: PubMed   Mentions: 20     Fields:    
    159. Measurement of amide hydrogen exchange by MALDI-TOF mass spectrometry. Anal Chem. 1998 Oct 01; 70(19):3987-95. Mandell JG, Falick AM, Komives EA. PMID: 9784743.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    160. Generation of protease-deficient strains and their use in heterologous protein expression. Methods Mol Biol. 1998; 103:81-94. Gleeson MA, White CE, Meininger DP, Komives EA. PMID: 9680635.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    161. Structure of the fifth EGF-like domain of thrombomodulin: An EGF-like domain with a novel disulfide-bonding pattern. J Mol Biol. 1997 Nov 07; 273(4):913-26. Sampoli Benitez BA, Hunter MJ, Meininger DP, Komives EA. PMID: 9367781.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    162. Energetics of thrombin-thrombomodulin interaction. Biochemistry. 1997 Jun 03; 36(22):6674-81. Vindigni A, White CE, Komives EA, Di Cera E. PMID: 9184147.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    163. The structural basis for pseudoreversion of the H95N lesion by the secondary S96P mutation in triosephosphate isomerase. Biochemistry. 1996 Dec 03; 35(48):15474-84. Komives EA, Lougheed JC, Zhang Z, Sugio S, Narayana N, Xuong NH, Petsko GA, Ringe D. PMID: 8952501.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    164. The fifth epidermal growth factor-like domain of thrombomodulin does not have an epidermal growth factor-like disulfide bonding pattern. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10177-82. White CE, Hunter MJ, Meininger DP, Garrod S, Komives EA. PMID: 8816772; PMCID: PMC38357.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    165. Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin. Protein Sci. 1996 Feb; 5(2):195-203. Hrabal R, Komives EA, Ni F. PMID: 8745396; PMCID: PMC2143349.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    166. Large-scale expression, purification and characterization of small fragments of thrombomodulin: the roles of the sixth domain and of methionine 388. Protein Eng. 1995 Nov; 8(11):1177-87. White CE, Hunter MJ, Meininger DP, White LR, Komives EA. PMID: 8819984.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    167. The structural basis for pseudoreversion of the E165D lesion by the secondary S96P mutation in triosephosphate isomerase depends on the positions of active site water molecules. Biochemistry. 1995 Oct 17; 34(41):13612-21. Komives EA, Lougheed JC, Liu K, Sugio S, Zhang Z, Petsko GA, Ringe D. PMID: 7577950.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    168. Thrombin-binding affinities of different disulfide-bonded isomers of the fifth EGF-like domain of thrombomodulin. Protein Sci. 1995 Oct; 4(10):2129-37. Hunter MJ, Komives EA. PMID: 8535250; PMCID: PMC2142985.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    169. Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin. Protein Sci. 1995 Sep; 4(9):1683-95. Meininger DP, Hunter MJ, Komives EA. PMID: 8528067; PMCID: PMC2143218.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    170. Deprotection of S-acetamidomethyl cysteine-containing peptides by silver trifluoromethanesulfonate avoids the oxidation of methionines. Anal Biochem. 1995 Jun 10; 228(1):173-7. Hunter MJ, Komives EA. PMID: 8572278.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    171. Thrombin inhibition by cyclic peptides from thrombomodulin. Protein Sci. 1995 Apr; 4(4):773-80. Lougheed JC, Bowman CL, Meininger DP, Komives EA. PMID: 7613475; PMCID: PMC2143091.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    172. Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects. Biochemistry. 1994 Nov 22; 33(46):13553-60. Srinivasan J, Hu S, Hrabal R, Zhu Y, Komives EA, Ni F. PMID: 7947766.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    173. Expression of highly disulfide-bonded proteins in Pichia pastoris. Structure. 1994 Nov 15; 2(11):1003-5. White CE, Kempi NM, Komives EA. PMID: 7881900.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    174. The precursor of the Streptomyces R61 DD-peptidase containing a C-terminal extension is inactive. FEBS Lett. 1994 Aug 29; 351(1):49-52. Fanuel L, Granier B, Wilkin JM, Bellefroid-Bourguignon C, Joris B, Knowles J, Komives E, Van Beeumen J, Ghuysen JM, Frère JM. PMID: 8076692.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    175. Triosephosphate isomerase requires a positively charged active site: the role of lysine-12. Biochemistry. 1994 Mar 15; 33(10):2809-14. Lodi PJ, Chang LC, Knowles JR, Komives EA. PMID: 8130193.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    176. Crystal structure of the K12M/G15A triosephosphate isomerase double mutant and electrostatic analysis of the active site. Biochemistry. 1994 Mar 15; 33(10):2815-23. Joseph-McCarthy D, Lolis E, Komives EA, Petsko GA. PMID: 8130194.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    177. Crystal structure of the mutant yeast triosephosphate isomerase in which the catalytic base glutamic acid 165 is changed to aspartic acid. Biochemistry. 1994 Mar 15; 33(10):2824-9. Joseph-McCarthy D, Rost LE, Komives EA, Petsko GA. PMID: 7907502.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    178. Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution. Biochemistry. 1994 Mar 15; 33(10):2830-7. Zhang Z, Sugio S, Komives EA, Liu KD, Knowles JR, Petsko GA, Ringe D. PMID: 8130195.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    179. cDNA sequence of rabbit tissue factor pathway inhibitor. Nucleic Acids Res. 1992 Jul 11; 20(13):3548. Warn-Cramer BJ, Broze GJ, Komives EA. PMID: 1630940; PMCID: PMC312531.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    180. Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95. Biochemistry. 1991 Mar 26; 30(12):3011-9. Komives EA, Chang LC, Lolis E, Tilton RF, Petsko GA, Knowles JR. PMID: 2007138.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    181. Mechanism of oxidation of pi bonds by cytochrome P-450. Electronic requirements of the transition state in the turnover of phenylacetylenes. J Biol Chem. 1987 Jul 15; 262(20):9793-802. Komives EA, Ortiz de Montellano PR. PMID: 3597438.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    182. Killing and mutation of human lymphoblast cells by aflatoxin B1: evidence for an inducible repair response. Cancer Res. 1987 Apr 15; 47(8):1993-2001. Kaden DA, Call KM, Leong PM, Komives EA, Thilly WG. PMID: 3103909.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    183. Branchpoint for heme alkylation and metabolite formation in the oxidation of arylacetylenes by cytochrome P-450. J Biol Chem. 1985 Mar 25; 260(6):3330-6. Ortiz de Montellano PR, Komives EA. PMID: 3972828.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    184. Mutation of xeroderma pigmentosum lymphoblasts by far-ultraviolet light. Mutat Res. 1984 Aug; 128(1):47-57. DeLuca JG, Kaden DA, Komives EA, Thilly WG. PMID: 6472306.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    185. The applicant interview as a predictor of resident performance. J Med Educ. 1984 May; 59(5):425-6. Komives E, Weiss ST, Rosa RM. PMID: 6716433.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    186. Mutation of human lymphoblasts exposed to low concentrations of chemical mutagens for long periods of time. Mutat Res. 1983 Mar; 108(1-3):417-36. Penman BW, Crespi CL, Komives EA, Liber HL, Thilly WG. PMID: 6403847.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
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