Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Laurence Brunton

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0636
    CA La Jolla 92093
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Harvard College, Cambridge, MABA06/1969Biochemical Sciences
      University of Virginia, Charlottesville, VAPh.D.05/1976Molecular Pharmacology
      Collapse Awards and Honors
      National Academy of Medicine (Mexico)2007Elected to membership
      Skaggs School of Pharmacy & Pharmaceutical Sciences, UCSD2007Excellence in Teaching
      UC San Diego2004  - 2005Community Champion Award (furthering diversity)

      Collapse Overview 
      Collapse Overview
      I am an emeritus professor at the UCSD School of Medicine and an experienced researcher in cardiovascular physiology and pharmacology (cyclic nucleotide metabolism, subcellular compartmentation of signaling) and an experienced reviewer of research and training grants in the US and Mexico. I have served as an advisor to the CA Air Resources Board, as chair of the Biomedical Sciences Ph.D. Program, and as mentor for the Industry-UC Research Partnership Fellowship. I am the founding director of the UCSD Pharmacology Summer Undergraduate Research Fellowship program (to place under-represented students in research labs and recruit them to grad school), an NIH-funded research techniques course in physiology and pharmacology, and the San Diego IRACDA Program (Institutional Research and Academic Career Development Award, a NIGMS-funded postdoctoral program with a minority emphasis). Currently: My chief academic activity is as editor-in-chief of the major textbook in my field, Goodman and Gilman’s The Pharmacological Basis of Therapeutics, along with maintaining a webpage based on the book and preparing a student version, Goodman and Gilman’s Manual of Pharmacology and Therapeutics and aiding development of the Goodman & Gilman Workbook and Casebook. I serve on the advisory board for post-baccalaureate programs at Cal State University Los Angeles and am active in organizations that combat global warming and promote environmental health and economic justice.


      Collapse Research 
      Collapse Research Activities and Funding
      Goodman & Gilman's The Pharmacological Basis of Therapeutics, 13th edition
      McGraw-Hill Education Jan 1, 2015
      Role: Editor-in-Chief
      Role Description: Coordinate, write, draw, tabulate, and edit information in 71 chapters for major multi-authored pharmacology text
      Systems Pharmacology and Translational Biology
      NIH/NIGMS R25GM074118Apr 1, 2005 - Mar 31, 2010
      Role: Principal Investigator
      San Diego IRACDA: Professors for the Future
      NIH/NIGMS K12GM068524Aug 1, 2003 - Jun 30, 2021
      Role: Co-Principal Investigator
      CYCLIC AMP METABOLISM IN CARDIAC MYOCYTES
      NIH/NHLBI R01HL041307Apr 1, 1989 - Jun 30, 2000
      Role: Principal Investigator
      COMPARTMENTATION OF CYCLIC AMP ACTION
      NIH/NHLBI K04HL000935Aug 1, 1981 - Jul 31, 1986
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Featured Publications
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Abbott RB, Hui KK, Hays RD, Mandel J, Goldstein M, Winegarden B, Glaser D, Brunton L. Medical Student Attitudes toward Complementary, Alternative and Integrative Medicine. Evid Based Complement Alternat Med. 2011; 2011:985243. PMID: 21826186; PMCID: PMC3147138.
        View in: PubMed, PubMed Central
      2. Villarreal F, Epperson SA, Ramirez-Sanchez I, Yamazaki KG, Brunton L. Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K. Am J Physiol Cell Physiol. 2009 May; 296(5):C1178-84. PMID: 19279233; PMCID: PMC2681376.
        View in: PubMed, PubMed Central
      3. Epperson SA, Brunton L, Ramirez-Sanchez I, Villarreal F. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2009 May; 296(5):C1171-7. PMID: 19244482; PMCID: PMC2681375.
        View in: PubMed, PubMed Central
      4. Hilal-Dandan R, He H, Martin JL, Brunton L, Dillmann WH. Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H728-34. PMID: 19151257; PMCID: PMC2660228.
        View in: PubMed, PubMed Central
      5. Shankley N, Cox BF, Brunton L. Who's afraid of ligand-macromolecule interactions in complex physiological systems? Mol Interv. 2006 Dec; 6(6):296-9. PMID: 17200455.
        View in: PubMed
      6. Bylund DB, Brunton L, Cobbett PJ, Persky AM, Preusch PC. NIGMS-sponsored integrative and organ systems pharmacology: synopsis of the 2005 experience/anticipation of the 2006 short courses. Mol Interv. 2005 Dec; 5(6):330-3. PMID: 16394246.
        View in: PubMed
      7. Brunton L. A positive feedback loop contributes to the deleterious effects of angiotensin. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14483-4. PMID: 16203975; PMCID: PMC1253591.
        View in: PubMed, PubMed Central
      8. Hilal-Dandan R, Means CK, Gustafsson AB, Morissette MR, Adams JW, Brunton L, Heller Brown J. Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol. 2004 Apr; 36(4):481-93. PMID: 15081308.
        View in: PubMed
      9. Akamine P, Brunton L, Ou HD, Canaves JM, Xuong NH, Taylor SS. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry. 2004 Jan 13; 43(1):85-96. PMID: 14705934.
        View in: PubMed
      10. Brunton L. PDE4: arrested at the border. Sci STKE. 2003 Oct 14; 2003(204):PE44. PMID: 14560046.
        View in: PubMed
      11. Saucerman JJ, Brunton L, Michailova AP, McCulloch AD. Modeling beta-adrenergic control of cardiac myocyte contractility in silico. J Biol Chem. 2003 Nov 28; 278(48):47997-8003. PMID: 12972422.
        View in: PubMed
      12. Suarez J, Belke DD, Gloss B, Dieterle T, McDonough PM, Kim YK, Brunton L, Dillmann WH. In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2004 Jan; 286(1):H68-75. PMID: 12958030.
        View in: PubMed
      13. Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton L, Meszaros JG. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. J Biol Chem. 2003 Jul 04; 278(27):24461-8. PMID: 12711600.
        View in: PubMed
      14. Reiner DS, Hetsko ML, Meszaros JG, Sun CH, Morrison HG, Brunton L, Gillin FD. Calcium signaling in excystation of the early diverging eukaryote, Giardia lamblia. J Biol Chem. 2003 Jan 24; 278(4):2533-40. PMID: 12397071.
        View in: PubMed
      15. Beavo JA, Brunton L. Cyclic nucleotide research -- still expanding after half a century. Nat Rev Mol Cell Biol. 2002 09; 3(9):710-8. PMID: 12209131.
        View in: PubMed
      16. Gustafsson AB, Brunton L. Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2. Am J Physiol Cell Physiol. 2002 Aug; 283(2):C463-71. PMID: 12107056.
        View in: PubMed
      17. Zambon AC, Brunton L, Barrett KE, Hughes RJ, Torres B, Insel PA. Cloning, expression, signaling mechanisms, and membrane targeting of P2Y(11) receptors in Madin Darby canine kidney cells. Mol Pharmacol. 2001 Jul; 60(1):26-35. PMID: 11408597.
        View in: PubMed
      18. Steinberg SF, Brunton L. Compartmentation of G protein-coupled signaling pathways in cardiac myocytes. Annu Rev Pharmacol Toxicol. 2001; 41:751-73. PMID: 11264475.
        View in: PubMed
      19. Meszaros JG, Raphael R, Lio FM, Brunton L. Protein kinase C contributes to desensitization of ANG II signaling in adult rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1978-85. PMID: 11078714.
        View in: PubMed
      20. Gustafsson AB, Brunton L. beta-adrenergic stimulation of rat cardiac fibroblasts enhances induction of nitric-oxide synthase by interleukin-1beta via message stabilization. Mol Pharmacol. 2000 Dec; 58(6):1470-8. PMID: 11093787.
        View in: PubMed
      21. Zambon AC, Hughes RJ, Meszaros JG, Wu JJ, Torres B, Brunton L, Insel PA. P2Y(2) receptor of MDCK cells: cloning, expression, and cell-specific signaling. Am J Physiol Renal Physiol. 2000 Dec; 279(6):F1045-52. PMID: 11097622.
        View in: PubMed
      22. Hilal-Dandan R, Kanter JR, Brunton L. Characterization of G-protein signaling in ventricular myocytes from the adult mouse heart: differences from the rat. J Mol Cell Cardiol. 2000 Jul; 32(7):1211-21. PMID: 10860764.
        View in: PubMed
      23. Welsh SJ, Titley J, Brunton L, Valenti M, Monaghan P, Jackman AL, Aherne GW. Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues. Clin Cancer Res. 2000 Jun; 6(6):2538-46. PMID: 10873110.
        View in: PubMed
      24. Meszaros JG, Gonzalez AM, Endo-Mochizuki Y, Villegas S, Villarreal F, Brunton L. Identification of G protein-coupled signaling pathways in cardiac fibroblasts: cross talk between G(q) and G(s). Am J Physiol Cell Physiol. 2000 Jan; 278(1):C154-62. PMID: 10644523.
        View in: PubMed
      25. Setyawan J, Koide K, Diller TC, Bunnage ME, Taylor SS, Nicolaou KC, Brunton L. Inhibition of protein kinases by balanol: specificity within the serine/threonine protein kinase subfamily. Mol Pharmacol. 1999 Aug; 56(2):370-6. PMID: 10419556.
        View in: PubMed
      26. Gustafsson AB, Brunton L. Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. Mol Pharmacol. 1999 Aug; 56(2):377-82. PMID: 10419557.
        View in: PubMed
      27. Narayana N, Diller TC, Koide K, Bunnage ME, Nicolaou KC, Brunton L, Xuong NH, Ten Eyck LF, Taylor SS. Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry. 1999 Feb 23; 38(8):2367-76. PMID: 10029530.
        View in: PubMed
      28. Martin JL, Mestril R, Hilal-Dandan R, Brunton L, Dillmann WH. Small heat shock proteins and protection against ischemic injury in cardiac myocytes. Circulation. 1997 Dec 16; 96(12):4343-8. PMID: 9416902.
        View in: PubMed
      29. Hilal-Dandan R, Villegas S, Gonzalez A, Brunton L. The quasi-irreversible nature of endothelin binding and G protein-linked signaling in cardiac myocytes. J Pharmacol Exp Ther. 1997 Apr; 281(1):267-73. PMID: 9103506.
        View in: PubMed
      30. Hilal-Dandan R, Ramirez MT, Villegas S, Gonzalez A, Endo-Mochizuki Y, Brown JH, Brunton L. Endothelin ETA receptor regulates signaling and ANF gene expression via multiple G protein-linked pathways. Am J Physiol. 1997 Jan; 272(1 Pt 2):H130-7. PMID: 9038931.
        View in: PubMed
      31. Villegas S, Brunton L. Separation of cyclic GMP and cyclic AMP. Anal Biochem. 1996 Mar 01; 235(1):102-3. PMID: 8850553.
        View in: PubMed
      32. Post SR, Hilal-Dandan R, Urasawa K, Brunton L, Insel PA. Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. Biochem J. 1995 Oct 01; 311 ( Pt 1):75-80. PMID: 7575483; PMCID: PMC1136121.
        View in: PubMed, PubMed Central
      33. Hilal-Dandan R, Brunton L. Transmembrane mechanochemical coupling in cardiac myocytes: novel activation of Gi by hyposmotic swelling. Am J Physiol. 1995 Sep; 269(3 Pt 2):H798-804. PMID: 7573520.
        View in: PubMed
      34. Koide K, Bunnage ME, Gomez Paloma L, Kanter JR, Taylor SS, Brunton L, Nicolaou KC. Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol. 1995 Sep; 2(9):601-8. PMID: 9383464.
        View in: PubMed
      35. Pucéat M, Hilal-Dandan R, Strulovici B, Brunton L, Brown JH. Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes. J Biol Chem. 1994 Jun 17; 269(24):16938-44. PMID: 8207017.
        View in: PubMed
      36. Hilal-Dandan R, Merck DT, Lujan JP, Brunton L. Coupling of the type A endothelin receptor to multiple responses in adult rat cardiac myocytes. Mol Pharmacol. 1994 Jun; 45(6):1183-90. PMID: 8022411.
        View in: PubMed
      37. Brunton L. Received knowledge. Nature. 1994 May 26; 369(6478):270. PMID: 8183359.
        View in: PubMed
      38. Hilal-Dandan R, Urasawa K, Brunton L. Endothelin inhibits adenylate cyclase and stimulates phosphoinositide hydrolysis in adult cardiac myocytes. J Biol Chem. 1992 May 25; 267(15):10620-4. PMID: 1316904.
        View in: PubMed
      39. McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton L, Grubin CE, Wignall JM, Jenkins NA, Brannan CI. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 1991 Oct; 10(10):2821-32. PMID: 1833184; PMCID: PMC452992.
        View in: PubMed, PubMed Central
      40. Speizer LA, Watson MJ, Brunton L. Differential effects of omega-3 fish oils on protein kinase activities in vitro. Am J Physiol. 1991 Jul; 261(1 Pt 1):E109-14. PMID: 1858866.
        View in: PubMed
      41. Lupton SD, Brunton L, Kalberg VA, Overell RW. Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene. Mol Cell Biol. 1991 Jun; 11(6):3374-8. PMID: 1645450; PMCID: PMC360192.
        View in: PubMed, PubMed Central
      42. Bode DC, Kanter JR, Brunton L. Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue. Circ Res. 1991 Apr; 68(4):1070-9. PMID: 1849058.
        View in: PubMed
      43. Heidenreich KA, Toledo SP, Brunton L, Watson MJ, Daniel-Issakani S, Strulovici B. Insulin stimulates the activity of a novel protein kinase C, PKC-epsilon, in cultured fetal chick neurons. J Biol Chem. 1990 Sep 05; 265(25):15076-82. PMID: 2203768.
        View in: PubMed
      44. Goodman MG, Speizer L, Bokoch G, Kanter J, Brunton L. Activity of an intracellular lymphocyte stimulator is independent of G-protein interactions, [Ca2+]i elevation, phosphoinositide hydrolysis, and protein kinase C translocation. J Biol Chem. 1990 Jul 25; 265(21):12248-52. PMID: 2165055.
        View in: PubMed
      45. Lupton SD, Gimpel S, Jerzy R, Brunton L, Hjerrild KA, Cosman D, Goodwin RG. Characterization of the human and murine IL-7 genes. J Immunol. 1990 May 01; 144(9):3592-601. PMID: 2329282.
        View in: PubMed
      46. Bell JD, Biltonen RL, Brunton L. Non-steady state kinetic analysis of the regulation of adenylate cyclase by GTP-binding proteins. Mol Pharmacol. 1990 Apr; 37(4):535-45. PMID: 2109182.
        View in: PubMed
      47. Speizer LA, Watson MJ, Kanter JR, Brunton L. Inhibition of phorbol ester binding and protein kinase C activity by heavy metals. J Biol Chem. 1989 Apr 05; 264(10):5581-5. PMID: 2494167.
        View in: PubMed
      48. Kanter JR, Hagey LR, Brunton L. Inhibition of cyclic AMP efflux by insect pheromones and fatty acids. FEBS Lett. 1989 Feb 13; 244(1):149-53. PMID: 2538347.
        View in: PubMed
      49. Mertens RB, Sherr HP, Mayer SE, Wheeler HO, Brunton L. Characterization of hormone-sensitive adenylate cyclase in rabbit gallbladder mucosa. Int J Biochem. 1989; 21(1):109-16. PMID: 2546833.
        View in: PubMed
      50. Bode DC, Brunton L. Post-receptor modulation of the effects of cyclic AMP in isolated cardiac myocytes. Mol Cell Biochem. 1988 Jul-Aug; 82(1-2):13-8. PMID: 2847010.
        View in: PubMed
      51. Brunton L, Heasley LE. cAMP export and its regulation by prostaglandin A1. Methods Enzymol. 1988; 159:83-93. PMID: 2842644.
        View in: PubMed
      52. Bode DC, Kanter JR, Brunton L. Resolution of soluble rat cardiac phosphodiesterases by high performance liquid chromatography. Second Messengers Phosphoproteins. 1988-1989; 12(5-6):235-40. PMID: 2856111.
        View in: PubMed
      53. Bell JD, Brunton L. Multiple effects of phorbol esters on hormone-sensitive adenylate cyclase activity in S49 lymphoma cells. Am J Physiol. 1987 Jun; 252(6 Pt 1):E783-9. PMID: 3035937.
        View in: PubMed
      54. Hammond HK, White FC, Brunton L, Longhurst JC. Association of decreased myocardial beta-receptors and chronotropic response to isoproterenol and exercise in pigs following chronic dynamic exercise. Circ Res. 1987 May; 60(5):720-6. PMID: 3036395.
        View in: PubMed
      55. Hammond HK, White FC, Buxton IL, Saltzstein P, Brunton L, Longhurst JC. Increased myocardial beta-receptors and adrenergic responses in hyperthyroid pigs. Am J Physiol. 1987 Feb; 252(2 Pt 2):H283-90. PMID: 3028177.
        View in: PubMed
      56. Bell JD, Brunton L. Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Withdrawal of GTP-dependent inhibition. J Biol Chem. 1986 Sep 15; 261(26):12036-41. PMID: 2875069.
        View in: PubMed
      57. Buxton IL, Brunton L. Alpha-adrenergic receptors on rat ventricular myocytes: characteristics and linkage to cAMP metabolism. Am J Physiol. 1986 Aug; 251(2 Pt 2):H307-13. PMID: 3017129.
        View in: PubMed
      58. Buxton IL, Brunton L. Compartmentation of hormone action in adult mammalian cardiomyocytes. Adv Exp Med Biol. 1986; 194:117-27. PMID: 3019100.
        View in: PubMed
      59. Brown JH, Buxton IL, Brunton L. Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes. Circ Res. 1985 Oct; 57(4):532-7. PMID: 2412720.
        View in: PubMed
      60. Heasley LE, Brunton L. Prostaglandin A1 metabolism and inhibition of cyclic AMP extrusion by avian erythrocytes. J Biol Chem. 1985 Sep 25; 260(21):11514-9. PMID: 2995340.
        View in: PubMed
      61. Heasley LE, Watson MJ, Brunton L. Putative inhibitor of cyclic AMP efflux: chromatography, amino acid composition, and identification as a prostaglandin A1-glutathione adduct. J Biol Chem. 1985 Sep 25; 260(21):11520-3. PMID: 2995341.
        View in: PubMed
      62. Buxton IL, Brunton L. Beta-adrenergic receptor subtypes and subcellular compartmentation of cyclic AMP and cyclic AMP-dependent protein kinase in rabbit cardiomyocytes. Biochem Int. 1985 Aug; 11(2):137-44. PMID: 2996547.
        View in: PubMed
      63. Buxton IL, Brunton L. Action of the cardiac alpha 1-adrenergic receptor. Activation of cyclic AMP degradation. J Biol Chem. 1985 Jun 10; 260(11):6733-7. PMID: 2987230.
        View in: PubMed
      64. Buxton IL, Rozansky D, Brunton L, Motulsky HJ. Effects of Na+ on the muscarinic cholinergic receptor of rat ventricular myocytes. J Cardiovasc Pharmacol. 1985 May-Jun; 7(3):476-81. PMID: 2410677.
        View in: PubMed
      65. Bell JD, Buxton IL, Brunton L. Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Putative effect of C kinase on alpha s-GTP-catalytic subunit interaction. J Biol Chem. 1985 Mar 10; 260(5):2625-8. PMID: 2857714.
        View in: PubMed
      66. Heasley LE, Azari J, Brunton L. Export of cyclic AMP from avian red cells. Independence from major membrane transporters and specific inhibition by prostaglandin A. Mol Pharmacol. 1985 Jan; 27(1):60-5. PMID: 2981402.
        View in: PubMed
      67. Buxton IL, Brunton L. Direct analysis of beta-adrenergic receptor subtypes on intact adult ventricular myocytes of the rat. Circ Res. 1985 Jan; 56(1):126-32. PMID: 2857116.
        View in: PubMed
      68. Heasley LE, Azari J, Brunton L. A glutathione adduct of prostaglandin A1 acts intracellularly to elevate cyclic AMP by inhibiting its extrusion. J Cyclic Nucleotide Protein Phosphor Res. 1985; 10(1):3-8. PMID: 2984263.
        View in: PubMed
      69. Saglikes Y, Massry SG, Iseki K, Brautbar N, Barndt R, Brunton L, Buxton IL, Vlachakis N, Campese VM. Effect of phosphate depletion on blood pressure and vascular reactivity to norepinephrine and angiotensin II in the rat. Am J Physiol. 1985 Jan; 248(1 Pt 2):F93-9. PMID: 3881979.
        View in: PubMed
      70. Reese JB, Mayer SE, Brunton L. Effects of adrenalectomy on activation of glycogen phosphorylase in rat myocardium. Am J Physiol. 1984 Sep; 247(3 Pt 1):E389-97. PMID: 6089585.
        View in: PubMed
      71. Bell JD, Buxton IL, Brunton L. A kinetic isotope dilution assay for glycerol. Anal Biochem. 1984 Jun; 139(2):305-8. PMID: 6089605.
        View in: PubMed
      72. Buxton IL, Brunton L. Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes. J Biol Chem. 1983 Sep 10; 258(17):10233-9. PMID: 6309796.
        View in: PubMed
      73. Torphy TJ, Freese WB, Rinard GA, Brunton L, Mayer SE. Cyclic nucleotide-dependent protein kinases in airway smooth muscle. J Biol Chem. 1982 Oct 10; 257(19):11609-16. PMID: 6288694.
        View in: PubMed
      74. Hayes JS, Brunton L. Functional compartments in cyclic nucleotide action. J Cyclic Nucleotide Res. 1982; 8(1):1-16. PMID: 6290550.
        View in: PubMed
      75. Brunton L, Hayes JS, Mayer SE. Functional compartmentation of cyclic AMP and protein kinase in heart. Adv Cyclic Nucleotide Res. 1981; 14:391-7. PMID: 6269390.
        View in: PubMed
      76. Kanter JR, Brunton L. Cautions on the use of the heat stable inhibitor of protein kinase: studies with S49 lymphoma cells. J Cyclic Nucleotide Res. 1981; 7(4):259-68. PMID: 6278009.
        View in: PubMed
      77. Hayes JS, Brunton L, Mayer SE. Selective activation of particulate cAMP-dependent protein kinase by isoproterenol and prostaglandin E1. J Biol Chem. 1980 Jun 10; 255(11):5113-9. PMID: 6154700.
        View in: PubMed
      78. Brunton L, Buss JE. Export of cyclic AMP by mammalian reticulocytes. J Cyclic Nucleotide Res. 1980; 6(5):369-77. PMID: 6260842.
        View in: PubMed
      79. Brunton L, Mayer SE. Extrusion of cyclic AMP from pigeon erythrocytes. J Biol Chem. 1979 Oct 10; 254(19):9714-20. PMID: 226526.
        View in: PubMed
      80. Brunton L, Hayes JS, Mayer SE. Hormonally specific phosphorylation of cardiac troponin I and activation of glycogen phosphorylase. Nature. 1979 Jul 05; 280(5717):78-80. PMID: 15305586.
        View in: PubMed
      81. Hayes JS, Brunton L, Brown JH, Reese JB, Mayer SE. Hormonally specific expression of cardiac protein kinase activity. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1570-4. PMID: 221898; PMCID: PMC383431.
        View in: PubMed, PubMed Central
      82. Rinard GA, Rubinfeld AR, Brunton L, Mayer SE. Depressed cyclic AMP levels in airways smooth muscle from asthmatic dogs. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1472-6. PMID: 220616; PMCID: PMC383275.
        View in: PubMed, PubMed Central
      83. Brunton L, Maguire ME, Anderson HJ, Gilman AG. Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. beta-Adrenergic and PGE1 receptors in parental and hybrid cells. J Biol Chem. 1977 Feb 25; 252(4):1293-302. PMID: 190227.
        View in: PubMed
      84. Brunton L, Wiklund RA, Van Arsdale PM, Gilman AG. Binding of (3H)prostaglandin E1 to putative receptors linked to adenylate cyclase of cultured cell clones. J Biol Chem. 1976 May 25; 251(10):3037-44. PMID: 5451.
        View in: PubMed
      85. Maguire ME, Brunton L, Wiklund RA, Anderson HI, Van Arsdale PM, Gilman AG. Hormone receptors and the control of cyclic AMP metabolism in parental and hybrid somatic cells. Recent Prog Horm Res. 1976; 32:633-67. PMID: 183249.
        View in: PubMed
      86. Guerrant RL, Brunton L, Schnaitman TC, Rebhun LI, Gilman AG. Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. Infect Immun. 1974 Aug; 10(2):320-7. PMID: 4368545; PMCID: PMC414999.
        View in: PubMed, PubMed Central
      Laurence's Networks
      Concepts
      Derived automatically from this person's publications.
      See all (467) concept(s)
      _
      Co-Authors
      People in Profiles who have published with this person.
      See all (13) people
      _
      Similar People
      People who share similar concepts with this person.
      See all (59) people
      _
      Same Department
      Search Department
      Physical Neighbors
      People whose addresses are nearby this person.
      _