 Laurence Brunton
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| Title(s) | Recall Faculty, Pharmacology |
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| School | Vc-health Sciences-schools |
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| Address | 9500 Gilman Drive #
La Jolla CA 92093
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| vCard | Download vCard |
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 Biography | Harvard College, Cambridge, MA | BA | 06/1969 | Biochemical Sciences | | University of Virginia, Charlottesville, VA | Ph.D. | 05/1976 | Molecular Pharmacology |
| National Academy of Medicine (Mexico) | 2007 | | Elected to membership | | Skaggs School of Pharmacy & Pharmaceutical Sciences, UCSD | 2007 | | Excellence in Teaching | | UC San Diego | 2004
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| 2005 | Community Champion Award (furthering diversity) |
Overview I am an emeritus professor at the UCSD School of Medicine and an experienced researcher in cardiovascular physiology and pharmacology (cyclic nucleotide metabolism, subcellular compartmentation of signaling) and an experienced reviewer of research and training grants in the US and Mexico. I have served as an advisor to the CA Air Resources Board, as chair of the Biomedical Sciences Ph.D. Program, and as mentor for the Industry-UC Research Partnership Fellowship. I am the founding director of the UCSD Pharmacology Summer Undergraduate Research Fellowship program (to place under-represented students in research labs and recruit them to grad school), an NIH-funded research techniques course in physiology and pharmacology, and the San Diego IRACDA Program (Institutional Research and Academic Career Development Award, a NIGMS-funded postdoctoral program with a minority emphasis). Currently: My chief academic activity is as editor-in-chief of the major textbook in my field, Goodman and Gilman’s The Pharmacological Basis of Therapeutics, along with maintaining a webpage based on the book and preparing a student version, Goodman and Gilman’s Manual of Pharmacology and Therapeutics and aiding development of the Goodman & Gilman Workbook and Casebook. I serve on the advisory board for post-baccalaureate programs at Cal State University Los Angeles and am active in organizations that combat global warming and promote environmental health and economic justice.
Research ORNG Applications Bibliographic
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Medical Student Attitudes toward Complementary, Alternative and Integrative Medicine. Evid Based Complement Alternat Med. 2011; 2011:985243.
Abbott RB, Hui KK, Hays RD, Mandel J, Goldstein M, Winegarden B, Glaser D, Brunton L. PMID: 21826186.
View in: PubMed Mentions:
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Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K. . 2009 May; 296(5):C1178-84.
Villarreal F, Epperson SA, Ramirez-Sanchez I, Yamazaki KG, Brunton LL. PMID: 19279233.
View in: PubMed Mentions:
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Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. . 2009 May; 296(5):C1171-7.
Epperson SA, Brunton LL, Ramirez-Sanchez I, Villarreal F. PMID: 19244482.
View in: PubMed Mentions:
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Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP. . 2009 Mar; 296(3):H728-34.
Hilal-Dandan R, He H, Martin JL, Brunton LL, Dillmann WH. PMID: 19151257.
View in: PubMed Mentions:
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Who's afraid of ligand-macromolecule interactions in complex physiological systems? Mol Interv. 2006 Dec; 6(6):296-9.
Shankley N, Cox BF, Brunton LL. PMID: 17200455.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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NIGMS-sponsored integrative and organ systems pharmacology: synopsis of the 2005 experience/anticipation of the 2006 short courses. Mol Interv. 2005 Dec; 5(6):330-3.
Bylund DB, Brunton LL, Cobbett PJ, Persky AM, Preusch PC. PMID: 16394246.
View in: PubMed Mentions: Fields: Translation: Animals
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A positive feedback loop contributes to the deleterious effects of angiotensin. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14483-4.
Brunton LL. PMID: 16203975.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol. 2004 Apr; 36(4):481-93.
Hilal-Dandan R, Means CK, Gustafsson AB, Morissette MR, Adams JW, Brunton LL, Heller Brown J. PMID: 15081308.
View in: PubMed Mentions: 20 Fields: Translation: AnimalsCells
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Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry. 2004 Jan 13; 43(1):85-96.
Akamine P, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor SS. PMID: 14705934.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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PDE4: arrested at the border. Sci STKE. 2003 Oct 14; 2003(204):PE44.
Brunton LL. PMID: 14560046.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Modeling beta-adrenergic control of cardiac myocyte contractility in silico. J Biol Chem. 2003 Nov 28; 278(48):47997-8003.
Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. PMID: 12972422.
View in: PubMed Mentions: 86 Fields: Translation: HumansAnimalsCells
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In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy. . 2004 Jan; 286(1):H68-75.
Suarez J, Belke DD, Gloss B, Dieterle T, McDonough PM, Kim YK, Brunton LL, Dillmann WH. PMID: 12958030.
View in: PubMed Mentions:
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Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. J Biol Chem. 2003 Jul 04; 278(27):24461-8.
Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG. PMID: 12711600.
View in: PubMed Mentions: 30 Fields: Translation: AnimalsCells
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Calcium signaling in excystation of the early diverging eukaryote, Giardia lamblia. J Biol Chem. 2003 Jan 24; 278(4):2533-40.
Reiner DS, Hetsko ML, Meszaros JG, Sun CH, Morrison HG, Brunton LL, Gillin FD. PMID: 12397071.
View in: PubMed Mentions: 13 Fields: Translation: AnimalsCells
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Cyclic nucleotide research -- still expanding after half a century. Nat Rev Mol Cell Biol. 2002 09; 3(9):710-8.
Beavo JA, Brunton LL. PMID: 12209131.
View in: PubMed Mentions: 255 Fields: Translation: HumansAnimalsCells
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Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2. . 2002 Aug; 283(2):C463-71.
Gustafsson AB, Brunton LL. PMID: 12107056.
View in: PubMed Mentions:
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| Year | Publications |
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| 2002 | 3 | | 2003 | 4 | | 2004 | 2 | | 2005 | 2 | | 2006 | 1 | | 2009 | 3 | | 2011 | 1 |
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