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Laurence Brunton

TitleRecall Faculty
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0636
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Harvard College, Cambridge, MABA06/1969Biochemical Sciences
    University of Virginia, Charlottesville, VAPh.D.05/1976Molecular Pharmacology
    Collapse Awards and Honors
    National Academy of Medicine (Mexico)2007Elected to membership
    Skaggs School of Pharmacy & Pharmaceutical Sciences, UCSD2007Excellence in Teaching
    UC San Diego2004  - 2005Community Champion Award (furthering diversity)

    Collapse Overview 
    Collapse Overview
    I am an emeritus professor at the UCSD School of Medicine and an experienced researcher in cardiovascular physiology and pharmacology (cyclic nucleotide metabolism, subcellular compartmentation of signaling) and an experienced reviewer of research and training grants in the US and Mexico. I have served as an advisor to the CA Air Resources Board, as chair of the Biomedical Sciences Ph.D. Program, and as mentor for the Industry-UC Research Partnership Fellowship. I am the founding director of the UCSD Pharmacology Summer Undergraduate Research Fellowship program (to place under-represented students in research labs and recruit them to grad school), an NIH-funded research techniques course in physiology and pharmacology, and the San Diego IRACDA Program (Institutional Research and Academic Career Development Award, a NIGMS-funded postdoctoral program with a minority emphasis). Currently: My chief academic activity is as editor-in-chief of the major textbook in my field, Goodman and Gilman’s The Pharmacological Basis of Therapeutics, along with maintaining a webpage based on the book and preparing a student version, Goodman and Gilman’s Manual of Pharmacology and Therapeutics and aiding development of the Goodman & Gilman Workbook and Casebook. I serve on the advisory board for post-baccalaureate programs at Cal State University Los Angeles and am active in organizations that combat global warming and promote environmental health and economic justice.


    Collapse Research 
    Collapse Research Activities and Funding
    Goodman & Gilman's The Pharmacological Basis of Therapeutics, 13th edition
    McGraw-Hill Education Jan 1, 2015
    Role: Editor-in-Chief
    Role Description: Coordinate, write, draw, tabulate, and edit information in 71 chapters for major multi-authored pharmacology text
    Systems Pharmacology and Translational Biology
    NIH/NIGMS R25GM074118Apr 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    San Diego IRACDA: Professors for the Future
    NIH/NIGMS K12GM068524Aug 1, 2003 - Jun 30, 2021
    Role: Co-Principal Investigator
    CYCLIC AMP METABOLISM IN CARDIAC MYOCYTES
    NIH/NHLBI R01HL041307Apr 1, 1989 - Jun 30, 2000
    Role: Principal Investigator
    COMPARTMENTATION OF CYCLIC AMP ACTION
    NIH/NHLBI K04HL000935Aug 1, 1981 - Jul 31, 1986
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Abbott RB, Hui KK, Hays RD, Mandel J, Goldstein M, Winegarden B, Glaser D, Brunton L. Medical Student Attitudes toward Complementary, Alternative and Integrative Medicine. Evid Based Complement Alternat Med. 2011; 2011:985243. PMID: 21826186; PMCID: PMC3147138.
    2. Villarreal F, Epperson SA, Ramirez-Sanchez I, Yamazaki KG, Brunton LL. Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K. Am J Physiol Cell Physiol. 2009 May; 296(5):C1178-84. PMID: 19279233; PMCID: PMC2681376.
    3. Epperson SA, Brunton LL, Ramirez-Sanchez I, Villarreal F. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2009 May; 296(5):C1171-7. PMID: 19244482; PMCID: PMC2681375.
    4. Hilal-Dandan R, He H, Martin JL, Brunton LL, Dillmann WH. Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H728-34. PMID: 19151257; PMCID: PMC2660228.
    5. Shankley N, Cox BF, Brunton LL. Who's afraid of ligand-macromolecule interactions in complex physiological systems? Mol Interv. 2006 Dec; 6(6):296-9. PMID: 17200455.
      View in: PubMed
    6. Bylund DB, Brunton LL, Cobbett PJ, Persky AM, Preusch PC. NIGMS-sponsored integrative and organ systems pharmacology: synopsis of the 2005 experience/anticipation of the 2006 short courses. Mol Interv. 2005 Dec; 5(6):330-3. PMID: 16394246.
      View in: PubMed
    7. Brunton LL. A positive feedback loop contributes to the deleterious effects of angiotensin. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14483-4. PMID: 16203975; PMCID: PMC1253591.
    8. Hilal-Dandan R, Means CK, Gustafsson AB, Morissette MR, Adams JW, Brunton LL, Heller Brown J. Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol. 2004 Apr; 36(4):481-93. PMID: 15081308.
      View in: PubMed
    9. Akamine P. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry. 2004 Jan 13; 43(1):85-96. PMID: 14705934.
      View in: PubMed
    10. Brunton LL. PDE4: arrested at the border. Sci STKE. 2003 Oct 14; 2003(204):PE44. PMID: 14560046.
      View in: PubMed
    11. Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. Modeling beta-adrenergic control of cardiac myocyte contractility in silico. J Biol Chem. 2003 Nov 28; 278(48):47997-8003. PMID: 12972422.
      View in: PubMed
    12. Suarez J, Belke DD, Gloss B, Dieterle T, McDonough PM, Kim YK, Brunton LL, Dillmann WH. In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2004 Jan; 286(1):H68-75. PMID: 12958030.
      View in: PubMed
    13. Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. J Biol Chem. 2003 Jul 04; 278(27):24461-8. PMID: 12711600.
      View in: PubMed
    14. Reiner DS, Hetsko ML, Meszaros JG, Sun CH, Morrison HG, Brunton LL, Gillin FD. Calcium signaling in excystation of the early diverging eukaryote, Giardia lamblia. J Biol Chem. 2003 Jan 24; 278(4):2533-40. PMID: 12397071.
      View in: PubMed
    15. Beavo JA, Brunton LL. Cyclic nucleotide research -- still expanding after half a century. Nat Rev Mol Cell Biol. 2002 09; 3(9):710-8. PMID: 12209131.
      View in: PubMed
    16. Gustafsson AB, Brunton LL. Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2. Am J Physiol Cell Physiol. 2002 Aug; 283(2):C463-71. PMID: 12107056.
      View in: PubMed
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