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Lorraine Pillus

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0347
La Jolla CA 92093
Phone858-822-2442
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    Collapse Research 
    Collapse Research Activities and Funding
    Network-Driven Dynamics of Replicative Aging
    NIH/NIA R01AG056440Aug 1, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Massively parallel epigenomics: building new value with current resources
    NIH/NHGRI R21HG005252Feb 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    Chromatin Regulation by Deacetylation and SUMO-Targeted Ubiquitin Ligation
    NIH/NIGMS R01GM090177Jul 1, 2009 - Jun 30, 2013
    Role: Principal Investigator
    Analysis of MYST Family Acetyltransferase Functions
    NIH/NIGMS R01GM056469Aug 1, 1997 - Jul 31, 2008
    Role: Principal Investigator
    Functional Analysis of the SIR2/HST Deacetylases
    NIH/NIGMS R01GM054778Aug 1, 1997 - Nov 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li Y, Jin M, O'Laughlin R, Bittihn P, Tsimring LS, Pillus L, Hasty J, Hao N. Multigenerational silencing dynamics control cell aging. Proc Natl Acad Sci U S A. 2017 Oct 17; 114(42):11253-11258. PMID: 29073021.
      View in: PubMed
    2. Searle NE, Pillus L. Critical genomic regulation mediated by Enhancer of Polycomb. Curr Genet. 2018 Feb; 64(1):147-154. PMID: 28884217.
      View in: PubMed
    3. Marquez-Lona EM, Torres-Machorro AL, Gonzales FR, Pillus L, Patrick GN. Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation. PLoS One. 2017; 12(6):e0179893. PMID: 28662109.
      View in: PubMed
    4. Mason AG, Garza RM, McCormick MA, Patel B, Kennedy BK, Pillus L, La Spada AR. The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. Aging Cell. 2017 Aug; 16(4):785-796. PMID: 28568901.
      View in: PubMed
    5. Searle NE, Torres-Machorro AL, Pillus L. Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. Genetics. 2017 03; 205(3):1125-1137. PMID: 28108589.
      View in: PubMed
    6. Petty EL, Lafon A, Tomlinson SL, Mendelsohn BA, Pillus L. Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae. Genetics. 2016 08; 203(4):1693-707. PMID: 27317677; PMCID: PMC4981271 [Available on 08/01/17].
    7. Su XB, Pillus L. Functions for diverse metabolic activities in heterochromatin. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):E1526-35. PMID: 26936955; PMCID: PMC4801238.
    8. Torres-Machorro AL, Clark LG, Chang CS, Pillus L. The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response. Mol Cell Biol. 2015 Nov; 35(21):3714-25. PMID: 26303527; PMCID: PMC4589593.
    9. Torres-Machorro AL, Aris JP, Pillus L. A moonlighting metabolic protein influences repair at DNA double-stranded breaks. Nucleic Acids Res. 2015 Feb 18; 43(3):1646-58. PMID: 25628362; PMCID: PMC4330366.
    10. Basnet H, Su XB, Tan Y, Meisenhelder J, Merkurjev D, Ohgi KA, Hunter T, Pillus L, Rosenfeld MG. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. Nature. 2014 Dec 11; 516(7530):267-71. PMID: 25252977; PMCID: PMC4461219.
    11. McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Rep. 2014 Jul 24; 8(2):477-86. PMID: 25043177; PMCID: PMC4284099.
    12. Torres-Machorro AL, Pillus L. Bypassing the requirement for an essential MYST acetyltransferase. Genetics. 2014 Jul; 197(3):851-63. PMID: 24831819; PMCID: PMC4096366.
    13. Eustice M, Pillus L. Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae. Genetics. 2014 Apr; 196(4):1029-39. PMID: 24532730; PMCID: PMC3982697.
    14. Petty E, Pillus L. Balancing chromatin remodeling and histone modifications in transcription. Trends Genet. 2013 Nov; 29(11):621-9. PMID: 23870137; PMCID: PMC4408995.
    15. Garza R, Pillus L. STUbLs in chromatin and genome stability. Biopolymers. 2013 Feb; 99(2):146-54. PMID: 23175389; PMCID: PMC3507437.
    16. Chen M, Licon K, Otsuka R, Pillus L, Ideker T. Decoupling epigenetic and genetic effects through systematic analysis of gene position. Cell Rep. 2013 Jan 31; 3(1):128-37. PMID: 23291096; PMCID: PMC3563736.
    17. Lafon A, Petty E, Pillus L. Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers. PLoS Genet. 2012; 8(10):e1002994. PMID: 23055944; PMCID: PMC3464200.
    18. Chang CS, Clarke A, Pillus L. Suppression analysis of esa1 mutants in Saccharomyces cerevisiae links NAB3 to transcriptional silencing and nucleolar functions. G3 (Bethesda). 2012 Oct; 2(10):1223-32. PMID: 23050233; PMCID: PMC3464115.
    19. Scott EM, Pillus L. Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage. Genes Dev. 2010 Sep 01; 24(17):1903-13. PMID: 20810648; PMCID: PMC2932972.
    20. Bulfer SL, Scott EM, Pillus L, Trievel RC. Structural basis for L-lysine feedback inhibition of homocitrate synthase. J Biol Chem. 2010 Apr 02; 285(14):10446-53. PMID: 20089861; PMCID: PMC2856251.
    21. Bulfer SL, Scott EM, Couture JF, Pillus L, Trievel RC. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J Biol Chem. 2009 Dec 18; 284(51):35769-80. PMID: 19776021; PMCID: PMC2791007.
    22. Jacobson S, Pillus L. The SAGA subunit Ada2 functions in transcriptional silencing. Mol Cell Biol. 2009 Nov; 29(22):6033-45. PMID: 19737915; PMCID: PMC2772568.
    23. Chang CS, Pillus L. Collaboration between the essential Esa1 acetyltransferase and the Rpd3 deacetylase is mediated by H4K12 histone acetylation in Saccharomyces cerevisiae. Genetics. 2009 Sep; 183(1):149-60. PMID: 19596907; PMCID: PMC2746140.
    24. Koch MR, Pillus L. The glucanosyltransferase Gas1 functions in transcriptional silencing. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11224-9. PMID: 19541632; PMCID: PMC2708717.
    25. Mak HC, Pillus L, Ideker T. Dynamic reprogramming of transcription factors to and from the subtelomere. Genome Res. 2009 Jun; 19(6):1014-25. PMID: 19372386; PMCID: PMC2694488.
    26. Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. Identifying critical non-catalytic residues that modulate protein kinase A activity. PLoS One. 2009; 4(3):e4746. PMID: 19270744; PMCID: PMC2650257.
    27. Pillus L. MYSTs mark chromatin for chromosomal functions. Curr Opin Cell Biol. 2008 Jun; 20(3):326-33. PMID: 18511253; PMCID: PMC2717219.
    28. Darst RP, Garcia SN, Koch MR, Pillus L. Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. Mol Cell Biol. 2008 Feb; 28(4):1361-72. PMID: 18086879; PMCID: PMC2258744.
    29. Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. New nomenclature for chromatin-modifying enzymes. Cell. 2007 Nov 16; 131(4):633-6. PMID: 18022353.
      View in: PubMed
    30. Kennedy EJ, Ghosh G, Pillus L. Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2. J Biol Chem. 2008 Jan 11; 283(2):1084-93. PMID: 17971450.
      View in: PubMed
    31. Wilson JM, Le VQ, Zimmerman C, Marmorstein R, Pillus L. Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep. 2006 Dec; 7(12):1247-51. PMID: 17110954; PMCID: PMC1794688.
    32. Ruault M, Pillus L. Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated. Genetics. 2006 Nov; 174(3):1135-49. PMID: 16951088; PMCID: PMC1667082.
    33. Clarke AS, Samal E, Pillus L. Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing. Mol Biol Cell. 2006 Apr; 17(4):1744-57. PMID: 16436512; PMCID: PMC1415314.
    34. Kennedy EJ, Pillus L, Ghosh G. Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryot Cell. 2005 Nov; 4(11):1892-901. PMID: 16278456; PMCID: PMC1287867.
    35. Wirén M, Silverstein RA, Sinha I, Walfridsson J, Lee HM, Laurenson P, Pillus L, Robyr D, Grunstein M, Ekwall K. Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast. EMBO J. 2005 Aug 17; 24(16):2906-18. PMID: 16079916; PMCID: PMC1187943.
    36. Lo WS, Gamache ER, Henry KW, Yang D, Pillus L, Berger SL. Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms. EMBO J. 2005 Mar 09; 24(5):997-1008. PMID: 15719021; PMCID: PMC554127.
    37. Freeman-Cook LL, Gómez EB, Spedale EJ, Marlett J, Forsburg SL, Pillus L, Laurenson P. Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+. Genetics. 2005 Mar; 169(3):1243-60. PMID: 15545655; PMCID: PMC1449530.
    38. Jacobson S, Pillus L. Molecular requirements for gene expression mediated by targeted histone acetyltransferases. Mol Cell Biol. 2004 Jul; 24(13):6029-39. PMID: 15199156; PMCID: PMC480887.
    39. Jacobson SJ, Laurenson PM, Pillus L. Functional analyses of chromatin modifications in yeast. Methods Enzymol. 2004; 377:3-55. PMID: 14979016.
      View in: PubMed
    40. Murphy GA, Spedale EJ, Powell ST, Pillus L, Schultz SC, Chen L. The Sir4 C-terminal coiled coil is required for telomeric and mating type silencing in Saccharomyces cerevisiae. J Mol Biol. 2003 Dec 05; 334(4):769-80. PMID: 14636601.
      View in: PubMed
    41. Henry KW, Wyce A, Lo WS, Duggan LJ, Emre NC, Kao CF, Pillus L, Shilatifard A, Osley MA, Berger SL. Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev. 2003 Nov 01; 17(21):2648-63. PMID: 14563679; PMCID: PMC280615.
    42. Clements A, Poux AN, Lo WS, Pillus L, Berger SL, Marmorstein R. Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. Mol Cell. 2003 Aug; 12(2):461-73. PMID: 14536085.
      View in: PubMed
    43. Lowell JE, Roughton AI, Lundblad V, Pillus L. Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae. Genetics. 2003 Jul; 164(3):909-21. PMID: 12871903; PMCID: PMC1462614.
    44. Parsons XH, Garcia SN, Pillus L, Kadonaga JT. Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1609-14. PMID: 12571358; PMCID: PMC149880.
    45. Garcia SN, Pillus L. A unique class of conditional sir2 mutants displays distinct silencing defects in Saccharomyces cerevisiae. Genetics. 2002 Oct; 162(2):721-36. PMID: 12399383; PMCID: PMC1462279.