Lorraine Pillus

InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0347
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Network-Driven Dynamics of Replicative Aging
    NIH/NIA R01AG056440Aug 1, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Massively parallel epigenomics: building new value with current resources
    NIH/NHGRI R21HG005252Feb 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    Chromatin Regulation by Deacetylation and SUMO-Targeted Ubiquitin Ligation
    NIH/NIGMS R01GM090177Jul 1, 2009 - Jun 30, 2013
    Role: Principal Investigator
    Analysis of MYST Family Acetyltransferase Functions
    NIH/NIGMS R01GM056469Aug 1, 1997 - Jul 31, 2008
    Role: Principal Investigator
    Functional Analysis of the SIR2/HST Deacetylases
    NIH/NIGMS R01GM054778Aug 1, 1997 - Nov 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Petty EL, Evpak M, Pillus L. Connecting GCN5's centromeric SAGA to the mitotic tension-sensing checkpoint. Mol Biol Cell. 2018 Jul 11; mbcE17120701. PMID: 29995571.
      View in: PubMed
    2. Li Y, Jin M, O'Laughlin R, Bittihn P, Tsimring LS, Pillus L, Hasty J, Hao N. Multigenerational silencing dynamics control cell aging. Proc Natl Acad Sci U S A. 2017 Oct 17; 114(42):11253-11258. PMID: 29073021.
      View in: PubMed
    3. Searle NE, Pillus L. Critical genomic regulation mediated by Enhancer of Polycomb. Curr Genet. 2018 Feb; 64(1):147-154. PMID: 28884217.
      View in: PubMed
    4. Marquez-Lona EM, Torres-Machorro AL, Gonzales FR, Pillus L, Patrick GN. Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation. PLoS One. 2017; 12(6):e0179893. PMID: 28662109.
      View in: PubMed
    5. Mason AG, Garza RM, McCormick MA, Patel B, Kennedy BK, Pillus L, La Spada AR. The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. Aging Cell. 2017 Aug; 16(4):785-796. PMID: 28568901.
      View in: PubMed
    6. Searle NE, Torres-Machorro AL, Pillus L. Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. Genetics. 2017 03; 205(3):1125-1137. PMID: 28108589.
      View in: PubMed
    7. Petty EL, Lafon A, Tomlinson SL, Mendelsohn BA, Pillus L. Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae. Genetics. 2016 08; 203(4):1693-707. PMID: 27317677; PMCID: PMC4981271 [Available on 08/01/17].
    8. Su XB, Pillus L. Functions for diverse metabolic activities in heterochromatin. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):E1526-35. PMID: 26936955; PMCID: PMC4801238.
    9. Torres-Machorro AL, Clark LG, Chang CS, Pillus L. The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response. Mol Cell Biol. 2015 Nov; 35(21):3714-25. PMID: 26303527; PMCID: PMC4589593.
    10. Torres-Machorro AL, Aris JP, Pillus L. A moonlighting metabolic protein influences repair at DNA double-stranded breaks. Nucleic Acids Res. 2015 Feb 18; 43(3):1646-58. PMID: 25628362; PMCID: PMC4330366.
    11. Basnet H, Su XB, Tan Y, Meisenhelder J, Merkurjev D, Ohgi KA, Hunter T, Pillus L, Rosenfeld MG. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. Nature. 2014 Dec 11; 516(7530):267-71. PMID: 25252977; PMCID: PMC4461219.
    12. McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Rep. 2014 Jul 24; 8(2):477-86. PMID: 25043177; PMCID: PMC4284099.
    13. Torres-Machorro AL, Pillus L. Bypassing the requirement for an essential MYST acetyltransferase. Genetics. 2014 Jul; 197(3):851-63. PMID: 24831819; PMCID: PMC4096366.
    14. Eustice M, Pillus L. Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae. Genetics. 2014 Apr; 196(4):1029-39. PMID: 24532730; PMCID: PMC3982697.
    15. Petty E, Pillus L. Balancing chromatin remodeling and histone modifications in transcription. Trends Genet. 2013 Nov; 29(11):621-9. PMID: 23870137; PMCID: PMC4408995.
    16. Garza R, Pillus L. STUbLs in chromatin and genome stability. Biopolymers. 2013 Feb; 99(2):146-54. PMID: 23175389; PMCID: PMC3507437.
    17. Chen M, Licon K, Otsuka R, Pillus L, Ideker T. Decoupling epigenetic and genetic effects through systematic analysis of gene position. Cell Rep. 2013 Jan 31; 3(1):128-37. PMID: 23291096; PMCID: PMC3563736.
    18. Lafon A, Petty E, Pillus L. Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers. PLoS Genet. 2012; 8(10):e1002994. PMID: 23055944; PMCID: PMC3464200.
    19. Chang CS, Clarke A, Pillus L. Suppression analysis of esa1 mutants in Saccharomyces cerevisiae links NAB3 to transcriptional silencing and nucleolar functions. G3 (Bethesda). 2012 Oct; 2(10):1223-32. PMID: 23050233; PMCID: PMC3464115.
    20. Scott EM, Pillus L. Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage. Genes Dev. 2010 Sep 01; 24(17):1903-13. PMID: 20810648; PMCID: PMC2932972.
    21. Bulfer SL, Scott EM, Pillus L, Trievel RC. Structural basis for L-lysine feedback inhibition of homocitrate synthase. J Biol Chem. 2010 Apr 02; 285(14):10446-53. PMID: 20089861; PMCID: PMC2856251.
    22. Bulfer SL, Scott EM, Couture JF, Pillus L, Trievel RC. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J Biol Chem. 2009 Dec 18; 284(51):35769-80. PMID: 19776021; PMCID: PMC2791007.
    23. Jacobson S, Pillus L. The SAGA subunit Ada2 functions in transcriptional silencing. Mol Cell Biol. 2009 Nov; 29(22):6033-45. PMID: 19737915; PMCID: PMC2772568.
    24. Chang CS, Pillus L. Collaboration between the essential Esa1 acetyltransferase and the Rpd3 deacetylase is mediated by H4K12 histone acetylation in Saccharomyces cerevisiae. Genetics. 2009 Sep; 183(1):149-60. PMID: 19596907; PMCID: PMC2746140.
    25. Koch MR, Pillus L. The glucanosyltransferase Gas1 functions in transcriptional silencing. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11224-9. PMID: 19541632; PMCID: PMC2708717.
    26. Mak HC, Pillus L, Ideker T. Dynamic reprogramming of transcription factors to and from the subtelomere. Genome Res. 2009 Jun; 19(6):1014-25. PMID: 19372386; PMCID: PMC2694488.
    27. Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. Identifying critical non-catalytic residues that modulate protein kinase A activity. PLoS One. 2009; 4(3):e4746. PMID: 19270744; PMCID: PMC2650257.
    28. Pillus L. MYSTs mark chromatin for chromosomal functions. Curr Opin Cell Biol. 2008 Jun; 20(3):326-33. PMID: 18511253; PMCID: PMC2717219.
    29. Darst RP, Garcia SN, Koch MR, Pillus L. Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. Mol Cell Biol. 2008 Feb; 28(4):1361-72. PMID: 18086879; PMCID: PMC2258744.
    30. Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. New nomenclature for chromatin-modifying enzymes. Cell. 2007 Nov 16; 131(4):633-6. PMID: 18022353.
      View in: PubMed
    31. Kennedy EJ, Ghosh G, Pillus L. Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2. J Biol Chem. 2008 Jan 11; 283(2):1084-93. PMID: 17971450.
      View in: PubMed
    32. Lafon A, Chang CS, Scott EM, Jacobson SJ, Pillus L. MYST opportunities for growth control: yeast genes illuminate human cancer gene functions. Oncogene. 2007 Aug 13; 26(37):5373-84. PMID: 17694079.
      View in: PubMed
    33. Wilson JM, Le VQ, Zimmerman C, Marmorstein R, Pillus L. Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep. 2006 Dec; 7(12):1247-51. PMID: 17110954; PMCID: PMC1794688.
    34. Ruault M, Pillus L. Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated. Genetics. 2006 Nov; 174(3):1135-49. PMID: 16951088; PMCID: PMC1667082.
    35. Clarke AS, Samal E, Pillus L. Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing. Mol Biol Cell. 2006 Apr; 17(4):1744-57. PMID: 16436512; PMCID: PMC1415314.
    36. Kennedy EJ, Pillus L, Ghosh G. Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryot Cell. 2005 Nov; 4(11):1892-901. PMID: 16278456; PMCID: PMC1287867.
    37. Wirén M, Silverstein RA, Sinha I, Walfridsson J, Lee HM, Laurenson P, Pillus L, Robyr D, Grunstein M, Ekwall K. Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast. EMBO J. 2005 Aug 17; 24(16):2906-18. PMID: 16079916; PMCID: PMC1187943.
    38. Lo WS, Gamache ER, Henry KW, Yang D, Pillus L, Berger SL. Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms. EMBO J. 2005 Mar 09; 24(5):997-1008. PMID: 15719021; PMCID: PMC554127.
    39. Freeman-Cook LL, Gómez EB, Spedale EJ, Marlett J, Forsburg SL, Pillus L, Laurenson P. Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+. Genetics. 2005 Mar; 169(3):1243-60. PMID: 15545655; PMCID: PMC1449530.
    40. Jacobson S, Pillus L. Molecular requirements for gene expression mediated by targeted histone acetyltransferases. Mol Cell Biol. 2004 Jul; 24(13):6029-39. PMID: 15199156; PMCID: PMC480887.
    41. Jacobson SJ, Laurenson PM, Pillus L. Functional analyses of chromatin modifications in yeast. Methods Enzymol. 2004; 377:3-55. PMID: 14979016.
      View in: PubMed
    42. Pillus L, Rine J. SIR1 and the origin of epigenetic states in Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol. 2004; 69:259-65. PMID: 16117657.
      View in: PubMed
    43. Murphy GA, Spedale EJ, Powell ST, Pillus L, Schultz SC, Chen L. The Sir4 C-terminal coiled coil is required for telomeric and mating type silencing in Saccharomyces cerevisiae. J Mol Biol. 2003 Dec 05; 334(4):769-80. PMID: 14636601.
      View in: PubMed
    44. Henry KW, Wyce A, Lo WS, Duggan LJ, Emre NC, Kao CF, Pillus L, Shilatifard A, Osley MA, Berger SL. Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev. 2003 Nov 01; 17(21):2648-63. PMID: 14563679; PMCID: PMC280615.
    45. Clements A, Poux AN, Lo WS, Pillus L, Berger SL, Marmorstein R. Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. Mol Cell. 2003 Aug; 12(2):461-73. PMID: 14536085.
      View in: PubMed
    46. Lowell JE, Roughton AI, Lundblad V, Pillus L. Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae. Genetics. 2003 Jul; 164(3):909-21. PMID: 12871903; PMCID: PMC1462614.
    47. Parsons XH, Garcia SN, Pillus L, Kadonaga JT. Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1609-14. PMID: 12571358; PMCID: PMC149880.
    48. Garcia SN, Pillus L. A unique class of conditional sir2 mutants displays distinct silencing defects in Saccharomyces cerevisiae. Genetics. 2002 Oct; 162(2):721-36. PMID: 12399383; PMCID: PMC1462279.
    49. Howe L, Auston D, Grant P, John S, Cook RG, Workman JL, Pillus L. Histone H3 specific acetyltransferases are essential for cell cycle progression. Genes Dev. 2001 Dec 01; 15(23):3144-54. PMID: 11731478; PMCID: PMC312843.
    50. Dutnall RN, Pillus L. Deciphering NAD-dependent deacetylases. Cell. 2001 Apr 20; 105(2):161-4. PMID: 11336664.
      View in: PubMed
    51. Stone EM, Reifsnyder C, McVey M, Gazo B, Pillus L. Two classes of sir3 mutants enhance the sir1 mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae. Genetics. 2000 Jun; 155(2):509-22. PMID: 10835377; PMCID: PMC1461112.
    52. Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5807-11. PMID: 10811920; PMCID: PMC18515.
    53. Stone EM, Heun P, Laroche T, Pillus L, Gasser SM. MAP kinase signaling induces nuclear reorganization in budding yeast. Curr Biol. 2000 Apr 06; 10(7):373-82. PMID: 10753745.
      View in: PubMed
    54. Freeman-Cook LL, Sherman JM, Brachmann CB, Allshire RC, Boeke JD, Pillus L. The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions. Mol Biol Cell. 1999 Oct; 10(10):3171-86. PMID: 10512858; PMCID: PMC25575.
    55. Allard S, Utley RT, Savard J, Clarke A, Grant P, Brandl CJ, Pillus L, Workman JL, Côté J. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J. 1999 Sep 15; 18(18):5108-19. PMID: 10487762; PMCID: PMC1171581.
    56. Sherman JM, Stone EM, Freeman-Cook LL, Brachmann CB, Boeke JD, Pillus L. The conserved core of a human SIR2 homologue functions in yeast silencing. Mol Biol Cell. 1999 Sep; 10(9):3045-59. PMID: 10473645; PMCID: PMC25551.
    57. Garcia SN, Pillus L. Net results of nucleolar dynamics. Cell. 1999 Jun 25; 97(7):825-8. PMID: 10399910.
      View in: PubMed
    58. Jacobson S, Pillus L. Modifying chromatin and concepts of cancer. Curr Opin Genet Dev. 1999 Apr; 9(2):175-84. PMID: 10322138.
      View in: PubMed
    59. Clarke AS, Lowell JE, Jacobson SJ, Pillus L. Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol. 1999 Apr; 19(4):2515-26. PMID: 10082517; PMCID: PMC84044.
    60. Smith JS, Brachmann CB, Pillus L, Boeke JD. Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p. Genetics. 1998 Jul; 149(3):1205-19. PMID: 9649515; PMCID: PMC1460222.
    61. Stone EM, Pillus L. Silent chromatin in yeast: an orchestrated medley featuring Sir3p [corrected]. Bioessays. 1998 Jan; 20(1):30-40. PMID: 9504045.
      View in: PubMed
    62. Lowell JE, Pillus L. Telomere tales: chromatin, telomerase and telomere function in Saccharomyces cerevisiae. Cell Mol Life Sci. 1998 Jan; 54(1):32-49. PMID: 9487385.
      View in: PubMed
    63. Nislow C, Ray E, Pillus L. SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell. 1997 Dec; 8(12):2421-36. PMID: 9398665; PMCID: PMC25717.
    64. Sherman JM, Pillus L. An uncertain silence. Trends Genet. 1997 Aug; 13(8):308-13. PMID: 9260516.
      View in: PubMed
    65. Laible G, Wolf A, Dorn R, Reuter G, Nislow C, Lebersorger A, Popkin D, Pillus L, Jenuwein T. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 1997 Jun 02; 16(11):3219-32. PMID: 9214638; PMCID: PMC1169939.
    66. Reifnyder C, Lowell J, Clarke A, Pillus L. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet. 1997 May; 16(1):109. PMID: 9140406.
      View in: PubMed
    67. Stone EM, Pillus L. Activation of an MAP kinase cascade leads to Sir3p hyperphosphorylation and strengthens transcriptional silencing. J Cell Biol. 1996 Nov; 135(3):571-83. PMID: 8909534; PMCID: PMC2121063.
    68. Reifsnyder C, Lowell J, Clarke A, Pillus L. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet. 1996 Sep; 14(1):42-9. PMID: 8782818.
      View in: PubMed
    69. Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L, Boeke JD. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev. 1995 Dec 01; 9(23):2888-902. PMID: 7498786.
      View in: PubMed
    70. Rivier DH, Pillus L. Silencing speaks up. Cell. 1994 Mar 25; 76(6):963-6. PMID: 8137430.
      View in: PubMed
    71. Palladino F, Laroche T, Gilson E, Axelrod A, Pillus L, Gasser SM. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell. 1993 Nov 05; 75(3):543-55. PMID: 8221893.
      View in: PubMed
    72. Palladino F, Laroche T, Gilson E, Pillus L, Gasser SM. The positioning of yeast telomeres depends on SIR3, SIR4, and the integrity of the nuclear membrane. Cold Spring Harb Symp Quant Biol. 1993; 58:733-46. PMID: 7956091.
      View in: PubMed
    73. Pillus L. An acquired state: epigenetic mechanisms in transcription. Curr Opin Cell Biol. 1992 Jun; 4(3):453-8. PMID: 1497916.
      View in: PubMed
    74. Pillus L, Rine J. Epigenetic inheritance of transcriptional states in S. cerevisiae. Cell. 1989 Nov 17; 59(4):637-47. PMID: 2684414.
      View in: PubMed
    75. Schatz PJ, Pillus L, Grisafi P, Solomon F, Botstein D. Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins. Mol Cell Biol. 1986 Nov; 6(11):3711-21. PMID: 3025610; PMCID: PMC367132.