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    Howard Cottam

    TitleRecall Non-faculty Academic
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-534-5424
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Goff PH, Hayashi T, He W, Yao S, Cottam H, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice. J Virol. 2017 Oct 01; 91(19). PMID: 28724768.
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      2. Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson DA, Cottam H, Shukla NM. Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-?B Activation without Intrinsic Activity. ACS Comb Sci. 2017 Aug 14; 19(8):533-543. PMID: 28657707.
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      3. Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. Hypoestoxide reduces neuroinflammation and a-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015 Dec 18; 12:236. PMID: 26683203; PMCID: PMC4683943.
      4. Shinchi H, Crain B, Yao S, Chan M, Zhang SS, Ahmadiiveli A, Suda Y, Hayashi T, Cottam H, Carson DA. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19; 26(8):1713-23. PMID: 26193334.
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      5. Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam H, Carson DA, Corr M. Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes. PLoS One. 2015; 10(6):e0129867. PMID: 26076454; PMCID: PMC4468074.
      6. Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam H, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015 Mar; 89(6):3221-35. PMID: 25568203; PMCID: PMC4337541.
      7. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam H. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. PMID: 25288184; PMCID: PMC4250372.
      8. Hayashi T, Crain B, Yao S, Caneda CD, Cottam H, Chan M, Corr M, Carson DA. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014 Aug; 350(2):330-40. PMID: 24893985; PMCID: PMC4109491.
      9. Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam H, Guiney DG, Corr M, Carson DA, Hayashi T. Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand. J Innate Immun. 2014; 6(3):315-24. PMID: 24192551; PMCID: PMC3972367.
      10. Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam H, Sankaran B, Taylor SS. Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. ACS Chem Biol. 2013 Oct 18; 8(10):2164-72. PMID: 23978166; PMCID: PMC3827627.
      11. Crain B, Yao S, Keophilaone V, Promessi V, Kang M, Barberis A, Maj R, Mura E, Passini N, Holldack J, Ochoa R, Cottam H, Carson DA, Hayashi T. Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. Eur J Dermatol. 2013 Sep-Oct; 23(5):618-28. PMID: 24225049; PMCID: PMC3959874.
      12. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam H. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. PMID: 23656327; PMCID: PMC3722616.
      13. Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam H, Carson DA, Corr M. Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. PLoS One. 2012; 7(9):e45860. PMID: 23029281; PMCID: PMC3461028.
      14. Pu M, Hayashi T, Cottam H, Mulvaney J, Arkin M, Corr M, Carson D, Messer K. Analysis of high-throughput screening assays using cluster enrichment. Stat Med. 2012 Dec 30; 31(30):4175-89. PMID: 22763983; PMCID: PMC3635947.
      15. Hayashi T, Yao S, Crain B, Chan M, Cottam H, Lao F, Carson DA, Corr M. Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand. Mediators Inflamm. 2012; 2012:262394. PMID: 22619481; PMCID: PMC3348532.
      16. Enzler T, Sano Y, Choo MK, Cottam H, Karin M, Tsao H, Park JM. Cell-selective inhibition of NF-?B signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov. 2011 Nov; 1(6):496-507. PMID: 22389871; PMCID: PMC3290412.
      17. Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, Tawatao RI, Kalenian K, Zhang Y, Hayashi Y, Lao FS, Cottam H, Carson DA. Synthesis and characterization of PEGylated toll like receptor 7 ligands. Bioconjug Chem. 2011 Mar 16; 22(3):445-54. PMID: 21338093; PMCID: PMC3063487.
      18. Hayashi T, Chan M, Norton JT, Wu CC, Yao S, Cottam H, Tawatao RI, Corr M, Carson DA, Daniels GA. Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2. Melanoma Res. 2011 Feb; 21(1):66-75. PMID: 21030882.
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      19. Wu RP, Hayashi T, Cottam H, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab RB, Carson DA. Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7479-84. PMID: 20368435; PMCID: PMC2867719.
      20. Hayashi T, Crain B, Corr M, Chan M, Cottam H, Maj R, Barberis A, Leoni L, Carson DA. Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. Int J Urol. 2010 May; 17(5):483-90. PMID: 20337728; PMCID: PMC3876967.
      21. Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, Corr M, Wrasidlo W, Cottam H, Carson DA. Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem. 2009 Jun; 20(6):1194-200. PMID: 19445505; PMCID: PMC2976567.
      22. Jin G, Lu D, Yao S, Wu CC, Liu JX, Carson DA, Cottam H. Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):606-9. PMID: 19121941.
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      23. Zhang L, Murray F, Zahno A, Kanter JR, Chou D, Suda R, Fenlon M, Rassenti L, Cottam H, Kipps TJ, Insel PA. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19532-7. PMID: 19033455; PMCID: PMC2614795.
      24. Hayashi T, Cottam H, Chan M, Jin G, Tawatao RI, Crain B, Ronacher L, Messer K, Carson DA, Corr M. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R123-32. PMID: 18480244; PMCID: PMC2494819.
      25. Ojo-Amaize EA, Cottam H, Oyemade OA, Okogun JI, Nchekwube EJ. Hypoestoxide inhibits tumor growth in the mouse CT26 colon tumor model. World J Gastroenterol. 2007 Sep 14; 13(34):4586-8. PMID: 17729410; PMCID: PMC4611831.
      26. Ojo-Amaize EA, Nchekwube EJ, Cottam H, Oyemade OA, Adesomoju AA, Okogun JI. Plasmodium berghei: antiparasitic effects of orally administered hypoestoxide in mice. Exp Parasitol. 2007 Oct; 117(2):218-21. PMID: 17568581.
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      27. Wu CC, Hayashi T, Takabayashi K, Sabet M, Smee DF, Guiney DD, Cottam H, Carson DA. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3990-5. PMID: 17360465; PMCID: PMC1820696.
      28. Saldanha SA, Kaler G, Cottam H, Abagyan R, Taylor SS. Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Anal Chem. 2006 Dec 15; 78(24):8265-72. PMID: 17165815; PMCID: PMC3435108.
      29. Endo T, Nishio M, Enzler T, Cottam H, Fukuda T, James DF, Karin M, Kipps TJ. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007 Jan 15; 109(2):703-10. PMID: 16973958; PMCID: PMC1890820.
      30. Sabet M, Cottam H, Guiney DG. Modulation of cytokine production and enhancement of cell viability by TLR7 and TLR9 ligands during anthrax infection of macrophages. FEMS Immunol Med Microbiol. 2006 Aug; 47(3):369-79. PMID: 16872373.
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      31. Jin G, Wu CC, Tawatao RI, Chan M, Carson DA, Cottam H. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. Bioorg Med Chem Lett. 2006 Sep 01; 16(17):4559-63. PMID: 16784848.
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      32. Barnard DL, Day CW, Bailey K, Heiner M, Montgomery R, Lauridsen L, Winslow S, Hoopes J, Li JK, Lee J, Carson DA, Cottam H, Sidwell RW. Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral Res. 2006 Aug; 71(1):53-63. PMID: 16621037.
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      33. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam H, Lai MM, Raz E, Carson DA. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1828-33. PMID: 16446426; PMCID: PMC1413670.
      34. Jin G, Wu CC, Carson DA, Cottam H. Guanosine analog in the pyrido[2,3-d]pyrimidine ring system as a potential toll-like receptor agonist. Nucleosides Nucleotides Nucleic Acids. 2006; 25(12):1391-7. PMID: 17067960.
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      35. Lu D, Cottam H, Corr M, Carson DA. Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18567-71. PMID: 16352713; PMCID: PMC1317972.
      36. Batova A, Cottam H, Yu J, Diccianni MB, Carrera CJ, Yu AL. EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. Blood. 2006 Feb 01; 107(3):898-903. PMID: 16234352; PMCID: PMC1895892.
      37. Barchéchath SD, Tawatao RI, Corr M, Carson DA, Cottam H. Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. J Med Chem. 2005 Oct 06; 48(20):6409-22. PMID: 16190767.
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      38. Barchéchath SD, Tawatao RI, Corr M, Carson DA, Cottam H. Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. Bioorg Med Chem Lett. 2005 Apr 01; 15(7):1785-8. PMID: 15780606.
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      39. Kolluri SK, Corr M, James SY, Bernasconi M, Lu D, Liu W, Cottam H, Leoni LM, Carson DA, Zhang XK. The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2525-30. PMID: 15699354; PMCID: PMC548323.
      40. Lu D, Zhao Y, Tawatao R, Cottam H, Sen M, Leoni LM, Kipps TJ, Corr M, Carson DA. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3118-23. PMID: 14973184; PMCID: PMC365753.
      41. Wu CC, Castro JE, Motta M, Cottam H, Kyburz D, Kipps TJ, Corr M, Carson DA. Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells. Hum Gene Ther. 2003 Jun 10; 14(9):849-60. PMID: 12828856.
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      42. Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam H. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6646-51. PMID: 12738885; PMCID: PMC164501.
      43. Ojo-Amaize EA, Nchekwube EJ, Cottam H, Bai R, Verdier-Pinard P, Kakkanaiah VN, Varner JA, Leoni L, Okogun JI, Adesomoju AA, Oyemade OA, Hamel E. Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer Res. 2002 Jul 15; 62(14):4007-14. PMID: 12124334.
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      44. Shih H, Cottam H, Carson DA. Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors. Chem Pharm Bull (Tokyo). 2002 Mar; 50(3):364-7. PMID: 11911199.
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      45. Ojo-Amaize EA, Kapahi P, Kakkanaiah VN, Takahashi T, Shalom-Barak T, Cottam H, Adesomoju AA, Nchekwube EJ, Oyemade OA, Karin M, Okogun JI. Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cell Immunol. 2001 May 01; 209(2):149-57. PMID: 11446747.
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      46. Genini D, Adachi S, Chao Q, Rose DW, Carrera CJ, Cottam H, Carson DA, Leoni LM. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood. 2000 Nov 15; 96(10):3537-43. PMID: 11071652.
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      47. Shih H, Deng L, Carrera CJ, Adachi S, Cottam H, Carson DA. Rational design, synthesis and structure-activity relationships of antitumor (E)-2-benzylidene-1-tetralones and (E)-2-benzylidene-1-indanones. Bioorg Med Chem Lett. 2000 Mar 06; 10(5):487-90. PMID: 10743954.
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      48. Leoni LM, Hamel E, Genini D, Shih H, Carrera CJ, Cottam H, Carson DA. Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells. J Natl Cancer Inst. 2000 Feb 02; 92(3):217-24. PMID: 10655438.
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      49. Genini D, Budihardjo I, Plunkett W, Wang X, Carrera CJ, Cottam H, Carson DA, Leoni LM. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. J Biol Chem. 2000 Jan 07; 275(1):29-34. PMID: 10617581.
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      50. Chao Q, Deng L, Shih H, Leoni LM, Genini D, Carson DA, Cottam H. Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. J Med Chem. 1999 Sep 23; 42(19):3860-73. PMID: 10508435.
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      51. Leoni LM, Chao Q, Cottam H, Genini D, Rosenbach M, Carrera CJ, Budihardjo I, Wang X, Carson DA. Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9567-71. PMID: 9689121; PMCID: PMC21379.
      52. Leoni LM, Shih HC, Deng L, Tuey C, Walter G, Carson DA, Cottam H. Modulation of ceramide-activated protein phosphatase 2A activity by low molecular weight aromatic compounds. Biochem Pharmacol. 1998 Apr 01; 55(7):1105-11. PMID: 9605434.
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      53. Lee KS, Cottam H, Houglum K, Wasson DB, Carson D, Chojkier M. Pentoxifylline blocks hepatic stellate cell activation independently of phosphodiesterase inhibitory activity. Am J Physiol. 1997 Nov; 273(5 Pt 1):G1094-100. PMID: 9374707.
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      54. Cottam H, Shih H, Tehrani LR, Wasson DB, Carson DA. Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. J Med Chem. 1996 Jan 05; 39(1):2-9. PMID: 8568809.
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      55. Michael MA, Cottam H, Smee DF, Robins RK, Kini GD. Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines. J Med Chem. 1993 Oct 29; 36(22):3431-6. PMID: 8230133.
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      56. Cottam H, Wasson DB, Shih HC, Raychaudhuri A, Di Pasquale G, Carson DA. New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation. J Med Chem. 1993 Oct 29; 36(22):3424-30. PMID: 8230132.
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      57. Carson DA, Wasson DB, Esparza LM, Carrera CJ, Kipps TJ, Cottam H. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2970-4. PMID: 1348362; PMCID: PMC48785.
      58. Kini GD, Anderson JD, Sanghvi YS, Lewis AF, Smee DF, Revankar GR, Robins RK, Cottam H. Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system. J Med Chem. 1991 Oct; 34(10):3006-10. PMID: 1656042.
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      59. Smee DF, Alaghamandan HA, Gilbert J, Burger RA, Jin A, Sharma BS, Ramasamy K, Revankar GR, Cottam H, Jolley WB. Immunoenhancing properties and antiviral activity of 7-deazaguanosine in mice. Antimicrob Agents Chemother. 1991 Jan; 35(1):152-7. PMID: 1707603; PMCID: PMC244957.
      60. Girgis NS, Michael MA, Smee DF, Alaghamandan HA, Robins RK, Cottam H. Direct C-glycosylation of guanine analogues: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides. J Med Chem. 1990 Oct; 33(10):2750-5. PMID: 2170645.
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      61. Bontems RJ, Anderson JD, Smee DF, Jin A, Alaghamandan HA, Sharma BS, Jolley WB, Robins RK, Cottam H. Guanosine analogues. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents. J Med Chem. 1990 Aug; 33(8):2174-8. PMID: 2165164.
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      62. Smee DF, Alaghamandan HA, Cottam H, Jolley WB, Robins RK. Antiviral activity of the novel immune modulator 7-thia-8-oxoguanosine. J Biol Response Mod. 1990 Feb; 9(1):24-32. PMID: 2156954.
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      63. Ojo-Amaize EA, Rubalcava B, Avery TL, Cottam H, Matsumoto SS, Jolley WB, Robins RK. Activation of the respiratory burst in murine phagocytes by certain guanine ribonucleosides modified at the 7 and 8 positions: possible involvement of a pertussis toxin-sensitive G-protein. Immunol Lett. 1990 Jan; 23(3):173-8. PMID: 2106487.
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      64. Larson SB, Cottam H, Robins RK. Structure of 7-methyl-8-oxo-7,8-dihydroguanosine monohydrate. Acta Crystallogr C. 1989 Dec 15; 45 ( Pt 12):1979-83. PMID: 2635610.
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      65. Smee DF, Alaghamandan HA, Cottam H, Sharma BS, Jolley WB, Robins RK. Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent. Antimicrob Agents Chemother. 1989 Sep; 33(9):1487-92. PMID: 2817849; PMCID: PMC172688.
      66. Robins RK, Ojo-Amaize E, Parandoosh Z, Cottam H, Matsumoto SS, Revankar GR, Smee DF, Fujitaki JM, Willis RC, Rubalcava B. Nucleoside and nucleotide modulation of genetic expression--a new approach to chemotherapy. Adv Enzyme Regul. 1989; 29:97-121. PMID: 2517379.
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      67. Girgis NS, Cottam H, Larson SB, Robins RK. 2'-Deoxy-3,7-dideazaguanosine and related compounds. Synthesis of 6-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl) and 1-beta-D-arabinofuranosyl-1H-pyrrolo[3,2-c]pyridin-4(5H)-one via direct glycosylation of a pyrrole precursor. Nucleic Acids Res. 1987 Feb 11; 15(3):1217-26. PMID: 3593477; PMCID: PMC340519.
      68. Cottam H, Kazimierczuk Z, Geary S, McKernan PA, Revankar GR, Robins RK. Synthesis and biological activity of certain 6-substituted and 2,6-disubstituted 2'-deoxytubercidins prepared via the stereospecific sodium salt glycosylation procedure. J Med Chem. 1985 Oct; 28(10):1461-7. PMID: 2995666.
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      69. Petrie CR, Cottam H, McKernan PA, Robins RK, Revankar GR. Synthesis and biological activity of 6-azacadeguomycin and certain 3,4,6-trisubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides. J Med Chem. 1985 Aug; 28(8):1010-6. PMID: 4020823.
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      70. Cottam H, Petrie CR, McKernan PA, Goebel RJ, Dalley NK, Davidson RB, Robins RK, Revankar GR. Synthesis and biological activity of certain 3,4-disubstituted pyrazolo[3,4-d]pyrimidine nucleosides. J Med Chem. 1984 Sep; 27(9):1119-27. PMID: 6471066.
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      71. Ugarkar BG, Cottam H, McKernan PA, Robins RK, Revankar GR. Synthesis and antiviral/antitumor activities of certain pyrazolo[3,4-d]pyrimidine-4(5H)-selone nucleosides and related compounds. J Med Chem. 1984 Aug; 27(8):1026-30. PMID: 6086922.
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      72. Cottam H, Revankar GR, Robins RK. A convenient synthesis of 6-amino-1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidin-4-one and related 4,6-disubstituted pyrazolopyrimidine nucleosides. Nucleic Acids Res. 1983 Feb 11; 11(3):871-82. PMID: 6835838; PMCID: PMC325758.
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