Howard Cottam

Title(s)Recall Non-faculty Academic, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses. Pharmaceutics. 2024 Jan 13; 16(1). Abdelwahab WM, Auclair S, Borgogna T, Siram K, Riffey A, Bazin HG, Cottam HB, Hayashi T, Evans JT, Burkhart DJ. PMID: 38258117; PMCID: PMC10819884.
      View in: PubMed   Mentions:
    2. Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx. ACS Chem Biol. 2023 04 21; 18(4):982-993. Sako Y, Sato-Kaneko F, Shukla NM, Yao S, Belsuzarri MM, Chan M, Saito T, Lao FS, Kong H, Puffer M, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T. PMID: 37039433; PMCID: PMC10127211.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCellsPHPublic Health
    3. A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination. Vaccines (Basel). 2022 Oct 11; 10(10). Sato-Kaneko F, Yao S, Lao FS, Sako Y, Jin J, Shukla NM, Cottam HB, Chan M, Belsuzarri MM, Carson DA, Hayashi T. PMID: 36298559; PMCID: PMC9611830.
      View in: PubMed   Mentions: 2  
    4. A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity. Front Pharmacol. 2022; 13:869649. Shukla NM, Sato-Kaneko F, Yao S, Pu M, Chan M, Lao FS, Sako Y, Saito T, Messer K, Hayashi T, Cottam HB, Corr M, Carson DA. PMID: 35479316; PMCID: PMC9035538.
      View in: PubMed   Mentions: 2  
    5. Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects. ACS Chem Biol. 2022 04 15; 17(4):957-968. Shinchi H, Komaki F, Yuki M, Ohara H, Hayakawa N, Wakao M, Cottam HB, Hayashi T, Carson DA, Moroishi T, Suda Y. PMID: 35353497.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsPHPublic Health
    6. Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity. ACS Chem Biol. 2022 01 21; 17(1):217-229. Saito T, Shukla NM, Sato-Kaneko F, Sako Y, Hosoya T, Yao S, Lao FS, Messer K, Pu M, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34985883; PMCID: PMC8788586.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge. Front Immunol. 2021; 12:701445. Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34650551; PMCID: PMC8505803.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Sato-Kaneko F, Yao S, Lao FS, Nan J, Shpigelman J, Cheng A, Saito T, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Molina AJ, Corr M, Hayashi T, Carson DA. PMID: 34078669; PMCID: PMC8201894.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation. Bioorg Med Chem. 2021 08 01; 43:116242. Shukla NM, Chan M, Lao FS, Chu PJ, Belsuzarri M, Yao S, Nan J, Sato-Kaneko F, Saito T, Hayashi T, Corr M, Carson DA, Cottam HB. PMID: 34274759; PMCID: PMC8992012.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release. Front Pharmacol. 2021; 12:668609. Shpigelman J, Lao FS, Yao S, Li C, Saito T, Sato-Kaneko F, Nolan JP, Shukla NM, Pu M, Messer K, Cottam HB, Carson DA, Corr M, Hayashi T. PMID: 33935791; PMCID: PMC8085554.
      View in: PubMed   Mentions: 9  
    11. Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities. ACS Appl Bio Mater. 2021 03 15; 4(3):2732-2741. Shinchi H, Yuki M, Yamauchi T, Niimura M, Wakao M, Cottam HB, Hayashi T, Carson DA, Moroishi T, Suda Y. PMID: 35014312.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    12. Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Front Pharmacol. 2020; 11:607713. Hosoya T, Shukla NM, Fujita Y, Yao S, Lao FS, Baba H, Yasuda S, Cottam HB, Carson DA, Hayashi T, Corr M. PMID: 33390996; PMCID: PMC7773657.
      View in: PubMed   Mentions: 1  
    13. A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity. Front Immunol. 2020; 11:1207. Sato-Kaneko F, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Chu PJ, Burkhart D, Schoener R, Matsutani T, Carson DA, Corr M, Hayashi T. PMID: 32636840; PMCID: PMC7318308.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    14. Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands. Bioorg Med Chem Lett. 2020 02 01; 30(3):126840. Baba A, Wakao M, Shinchi H, Chan M, Hayashi T, Yao S, Cottam HB, Carson DA, Suda Y. PMID: 31864800.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli. J Med Chem. 2019 11 14; 62(21):9521-9540. Chan M, Lao FS, Chu PJ, Shpigelman J, Yao S, Nan J, Sato-Kaneko F, Li V, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 31603681; PMCID: PMC8992017.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α-Mannose as Adjuvants. Bioconjug Chem. 2019 11 20; 30(11):2811-2821. Shinchi H, Yamaguchi T, Moroishi T, Yuki M, Wakao M, Cottam HB, Hayashi T, Carson DA, Suda Y. PMID: 31560198.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators. ACS Med Chem Lett. 2018 Dec 13; 9(12):1156-1159. Shukla NM, Chan M, Hayashi T, Carson DA, Cottam HB. PMID: 30613317; PMCID: PMC6295859.
      View in: PubMed   Mentions: 7  
    18. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. Biomed Res Int. 2018; 2018:8091283. Sato-Kaneko F, Wang X, Yao S, Hosoya T, Lao FS, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Carson DA, Corr M, Hayashi T. PMID: 30406141; PMCID: PMC6199861.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    19. Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. SLAS Discov. 2018 10; 23(9):960-973. Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M. PMID: 29751735; PMCID: PMC6697428.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands. J Med Chem. 2017 11 22; 60(22):9142-9161. Chan M, Kakitsubata Y, Hayashi T, Ahmadi A, Yao S, Shukla NM, Oyama SY, Baba A, Nguyen B, Corr M, Suda Y, Carson DA, Cottam HB, Wakao M. PMID: 29049886; PMCID: PMC5940354.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    21. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice. J Virol. 2017 10 01; 91(19). Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M. PMID: 28724768; PMCID: PMC5599744.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    22. Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity. ACS Comb Sci. 2017 08 14; 19(8):533-543. Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 28657707; PMCID: PMC5841913.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    23. Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015 Dec 18; 12:236. Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. PMID: 26683203; PMCID: PMC4683943.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    24. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19; 26(8):1713-23. Shinchi H, Crain B, Yao S, Chan M, Zhang SS, Ahmadiiveli A, Suda Y, Hayashi T, Cottam HB, Carson DA. PMID: 26193334.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    25. Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes. PLoS One. 2015; 10(6):e0129867. Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam HB, Carson DA, Corr M. PMID: 26076454; PMCID: PMC4468074.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    26. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015 Mar; 89(6):3221-35. Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA. PMID: 25568203; PMCID: PMC4337541.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    27. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 25288184; PMCID: PMC4250372.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    28. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014 Aug; 350(2):330-40. Hayashi T, Crain B, Yao S, Caneda CD, Cottam HB, Chan M, Corr M, Carson DA. PMID: 24893985; PMCID: PMC4109491.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand. J Innate Immun. 2014; 6(3):315-24. Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T. PMID: 24192551; PMCID: PMC3972367.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    30. Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. ACS Chem Biol. 2013 Oct 18; 8(10):2164-72. Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor SS. PMID: 23978166; PMCID: PMC3827627.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    31. Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. Eur J Dermatol. 2013 Sep-Oct; 23(5):618-28. Crain B, Yao S, Keophilaone V, Promessi V, Kang M, Barberis A, Maj R, Mura E, Passini N, Holldack J, Ochoa R, Cottam HB, Carson DA, Hayashi T. PMID: 24225049; PMCID: PMC3959874.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    32. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 23656327; PMCID: PMC3722616.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    33. Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. PLoS One. 2012; 7(9):e45860. Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam HB, Carson DA, Corr M. PMID: 23029281; PMCID: PMC3461028.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    34. Analysis of high-throughput screening assays using cluster enrichment. Stat Med. 2012 Dec 30; 31(30):4175-89. Pu M, Hayashi T, Cottam H, Mulvaney J, Arkin M, Corr M, Carson D, Messer K. PMID: 22763983; PMCID: PMC3635947.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    35. Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand. Mediators Inflamm. 2012; 2012:262394. Hayashi T, Yao S, Crain B, Chan M, Cottam HB, Lao F, Carson DA, Corr M. PMID: 22619481; PMCID: PMC3348532.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    36. Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov. 2011 Nov; 1(6):496-507. Enzler T, Sano Y, Choo MK, Cottam HB, Karin M, Tsao H, Park JM. PMID: 22389871; PMCID: PMC3290412.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    37. Synthesis and characterization of PEGylated toll like receptor 7 ligands. Bioconjug Chem. 2011 Mar 16; 22(3):445-54. Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, Tawatao RI, Kalenian K, Zhang Y, Hayashi Y, Lao FS, Cottam HB, Carson DA. PMID: 21338093; PMCID: PMC3063487.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    38. Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2. Melanoma Res. 2011 Feb; 21(1):66-75. Hayashi T, Chan M, Norton JT, Wu CC, Yao S, Cottam HB, Tawatao RI, Corr M, Carson DA, Daniels GA. PMID: 21030882; PMCID: PMC3057341.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7479-84. Wu RP, Hayashi T, Cottam HB, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab RB, Carson DA. PMID: 20368435; PMCID: PMC2867719.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    40. Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. Int J Urol. 2010 May; 17(5):483-90. Hayashi T, Crain B, Corr M, Chan M, Cottam HB, Maj R, Barberis A, Leoni L, Carson DA. PMID: 20337728; PMCID: PMC3876967.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    41. Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem. 2009 Jun; 20(6):1194-200. Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, Corr M, Wrasidlo W, Cottam HB, Carson DA. PMID: 19445505; PMCID: PMC2976567.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    42. Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):606-9. Jin G, Lu D, Yao S, Wu CC, Liu JX, Carson DA, Cottam HB. PMID: 19121941; PMCID: PMC5940355.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    43. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19532-7. Zhang L, Murray F, Zahno A, Kanter JR, Chou D, Suda R, Fenlon M, Rassenti L, Cottam H, Kipps TJ, Insel PA. PMID: 19033455; PMCID: PMC2614795.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    44. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R123-32. Hayashi T, Cottam HB, Chan M, Jin G, Tawatao RI, Crain B, Ronacher L, Messer K, Carson DA, Corr M. PMID: 18480244; PMCID: PMC2494819.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    45. Hypoestoxide inhibits tumor growth in the mouse CT26 colon tumor model. World J Gastroenterol. 2007 Sep 14; 13(34):4586-8. Ojo-Amaize EA, Cottam HB, Oyemade OA, Okogun JI, Nchekwube EJ. PMID: 17729410; PMCID: PMC4611831.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    46. Plasmodium berghei: antiparasitic effects of orally administered hypoestoxide in mice. Exp Parasitol. 2007 Oct; 117(2):218-21. Ojo-Amaize EA, Nchekwube EJ, Cottam HB, Oyemade OA, Adesomoju AA, Okogun JI. PMID: 17568581.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    47. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3990-5. Wu CC, Hayashi T, Takabayashi K, Sabet M, Smee DF, Guiney DD, Cottam HB, Carson DA. PMID: 17360465; PMCID: PMC1820696.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    48. Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Anal Chem. 2006 Dec 15; 78(24):8265-72. Saldanha SA, Kaler G, Cottam HB, Abagyan R, Taylor SS. PMID: 17165815; PMCID: PMC3435108.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    49. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007 Jan 15; 109(2):703-10. Endo T, Nishio M, Enzler T, Cottam HB, Fukuda T, James DF, Karin M, Kipps TJ. PMID: 16973958; PMCID: PMC1890820.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    50. Modulation of cytokine production and enhancement of cell viability by TLR7 and TLR9 ligands during anthrax infection of macrophages. FEMS Immunol Med Microbiol. 2006 Aug; 47(3):369-79. Sabet M, Cottam HB, Guiney DG. PMID: 16872373.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    51. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. Bioorg Med Chem Lett. 2006 Sep 01; 16(17):4559-63. Jin G, Wu CC, Tawatao RI, Chan M, Carson DA, Cottam HB. PMID: 16784848.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    52. Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral Res. 2006 Aug; 71(1):53-63. Barnard DL, Day CW, Bailey K, Heiner M, Montgomery R, Lauridsen L, Winslow S, Hoopes J, Li JK, Lee J, Carson DA, Cottam HB, Sidwell RW. PMID: 16621037; PMCID: PMC7114261.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    53. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1828-33. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. PMID: 16446426; PMCID: PMC1413670.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    54. Guanosine analog in the pyrido[2,3-d]pyrimidine ring system as a potential toll-like receptor agonist. Nucleosides Nucleotides Nucleic Acids. 2006; 25(12):1391-7. Jin G, Wu CC, Carson DA, Cottam HB. PMID: 17067960.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    55. Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18567-71. Lu D, Cottam HB, Corr M, Carson DA. PMID: 16352713; PMCID: PMC1317972.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    56. EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. Blood. 2006 Feb 01; 107(3):898-903. Batova A, Cottam H, Yu J, Diccianni MB, Carrera CJ, Yu AL. PMID: 16234352; PMCID: PMC1895892.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    57. Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. J Med Chem. 2005 Oct 06; 48(20):6409-22. Barchéchath SD, Tawatao RI, Corr M, Carson DA, Cottam HB. PMID: 16190767.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    58. Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. Bioorg Med Chem Lett. 2005 Apr 01; 15(7):1785-8. Barchéchath SD, Tawatao RI, Corr M, Carson DA, Cottam HB. PMID: 15780606.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    59. The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2525-30. Kolluri SK, Corr M, James SY, Bernasconi M, Lu D, Liu W, Cottam HB, Leoni LM, Carson DA, Zhang XK. PMID: 15699354; PMCID: PMC548323.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    60. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3118-23. Lu D, Zhao Y, Tawatao R, Cottam HB, Sen M, Leoni LM, Kipps TJ, Corr M, Carson DA. PMID: 14973184; PMCID: PMC365753.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    61. Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells. Hum Gene Ther. 2003 Jun 10; 14(9):849-60. Wu CC, Castro JE, Motta M, Cottam HB, Kyburz D, Kipps TJ, Corr M, Carson DA. PMID: 12828856.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    62. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6646-51. Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB. PMID: 12738885; PMCID: PMC164501.
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    63. Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer Res. 2002 Jul 15; 62(14):4007-14. Ojo-Amaize EA, Nchekwube EJ, Cottam HB, Bai R, Verdier-Pinard P, Kakkanaiah VN, Varner JA, Leoni L, Okogun JI, Adesomoju AA, Oyemade OA, Hamel E. PMID: 12124334.
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    64. Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors. Chem Pharm Bull (Tokyo). 2002 Mar; 50(3):364-7. Shih H, Cottam HB, Carson DA. PMID: 11911199.
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