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Alexandr Kornev

TitleProject Scientist
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0654
La Jolla CA 92093
Phone858-534-8190
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kornev AP. Self-organization, entropy and allostery. Biochem Soc Trans. 2018 Apr 20. PMID: 29678954.
      View in: PubMed
    2. Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation. J Mol Biol. 2018 Mar 16; 430(6):881-889. PMID: 29410316.
      View in: PubMed
    3. Knape MJ, Ballez M, Burghardt NC, Zimmermann B, Bertinetti D, Kornev AP, Herberg FW. Divalent metal ions control activity and inhibition of protein kinases. Metallomics. 2017 Nov 15; 9(11):1576-1584. PMID: 29043344.
      View in: PubMed
    4. Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor SS, Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv. 2017 Apr; 3(4):e1600663. PMID: 28435869.
      View in: PubMed
    5. P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor SS, Amaro RE. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIa. Biochemistry. 2017 03 14; 56(10):1536-1545. PMID: 28221775.
      View in: PubMed
    6. Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):E931-E940. PMID: 28115705.
      View in: PubMed
    7. Kornev AP, Taylor SS. Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci. 2015 Nov; 40(11):628-647. PMID: 26481499.
      View in: PubMed
    8. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-1572. PMID: 26278174.
      View in: PubMed
    9. Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C ßII. Cell Rep. 2015 Aug 25; 12(8):1252-60. PMID: 26279568; PMCID: PMC4551583.
    10. Malmstrom RD, Kornev AP, Taylor SS, Amaro RE. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nat Commun. 2015 Jul 06; 6:7588. PMID: 26145448.
      View in: PubMed
    11. Zhang P, Kornev AP, Wu J, Taylor SS. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015 Jun 01; 7(2):227-238. PMID: 26097522.
      View in: PubMed
    12. Taylor SS, Shaw AS, Kannan N, Kornev AP. Integration of signaling in the kinome: Architecture and regulation of the aC Helix. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1567-74. PMID: 25891902; PMCID: PMC4577442 [Available on 10/01/16].
    13. Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. PMID: 25348715; PMCID: PMC4295384.
    14. McClendon CL, Kornev AP, Gilson MK, Taylor SS. Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4623-31. PMID: 25319261; PMCID: PMC4217441.
    15. Boras BW, Kornev A, Taylor SS, McCulloch AD. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIa activation in response to cAMP binding. J Biol Chem. 2014 Oct 24; 289(43):30040-51. PMID: 25202018; PMCID: PMC4208011.
    16. Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. Kinases and pseudokinases: lessons from RAF. Mol Cell Biol. 2014 May; 34(9):1538-46. PMID: 24567368; PMCID: PMC3993607.
    17. Bruystens JG, Wu J, Fortezzo A, Kornev AP, Blumenthal DK, Taylor SS. PKA RIa homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure. 2014 Jan 07; 22(1):59-69. PMID: 24316401; PMCID: PMC3963464.
    18. Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS, Kornev AP. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol. 2013 Oct; 11(10):e1001680. PMID: 24143133; PMCID: PMC3797032.
    19. Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013 Aug 29; 154(5):1036-1046. PMID: 23993095.
      View in: PubMed
    20. Taylor SS, Shaw A, Hu J, Meharena HS, Kornev A. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013 Aug; 41(4):981-6. PMID: 23863167; PMCID: PMC4399968.
    21. Taylor SS, Zhang P, Steichen JM, Keshwani MM, Kornev AP. PKA: lessons learned after twenty years. Biochim Biophys Acta. 2013 Jul; 1834(7):1271-8. PMID: 23535202; PMCID: PMC3763834.
    22. Taylor SS, Ilouz R, Zhang P, Kornev AP. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012 Oct; 13(10):646-58. PMID: 22992589; PMCID: PMC3985763.
    23. Taylor SS, Keshwani MM, Steichen JM, Kornev AP. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2517-28. PMID: 22889904; PMCID: PMC3415842.
    24. Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor SS. Localization and quaternary structure of the PKA RIß holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12443-8. PMID: 22797896; PMCID: PMC3411989.
    25. Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor SS. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. PMID: 22493239; PMCID: PMC3356610.
    26. Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor SS. Structure and allostery of the PKA RIIß tetrameric holoenzyme. Science. 2012 Feb 10; 335(6069):712-6. PMID: 22323819; PMCID: PMC3985767.
    27. Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor SS. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol. 2012 Jan 27; 415(4):666-79. PMID: 22138346; PMCID: PMC3445030.
    28. Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL, Kornev AP, Taylor SS, Dostmann WR. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure. 2011 Sep 07; 19(9):1317-27. PMID: 21893290; PMCID: PMC3168983.
    29. Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6067-72. PMID: 21441104; PMCID: PMC3076888.
    30. Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor SS. Realizing the allosteric potential of the tetrameric protein kinase A RIa holoenzyme. Structure. 2011 Feb 09; 19(2):265-76. PMID: 21300294; PMCID: PMC3097484.
    31. Taylor SS, Kornev AP. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci. 2011 Feb; 36(2):65-77. PMID: 20971646; PMCID: PMC3084033.
    32. Masterson LR, Cheng C, Yu T, Tonelli M, Kornev A, Taylor SS, Veglia G. Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol. 2010 Nov; 6(11):821-8. PMID: 20890288; PMCID: PMC3487389.
    33. Sjoberg TJ, Kornev AP, Taylor SS. Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha. Protein Sci. 2010 Jun; 19(6):1213-21. PMID: 20512974; PMCID: PMC2895245.
    34. Taylor SS, Kornev AP. Yet another "active" pseudokinase, Erb3. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8047-8. PMID: 20421461; PMCID: PMC2889589.
    35. Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor SS, Johnson DA. Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Mol Cell Proteomics. 2010 Oct; 9(10):2225-37. PMID: 20167947; PMCID: PMC2957725.
    36. Kornev AP, Taylor SS. Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta. 2010 Mar; 1804(3):440-4. PMID: 19879387; PMCID: PMC3435107.
    37. Thompson EE, Kornev AP, Kannan N, Kim C, Ten Eyck LF, Taylor SS. Comparative surface geometry of the protein kinase family. Protein Sci. 2009 Oct; 18(10):2016-26. PMID: 19610074; PMCID: PMC2786965.
    38. Romano RA, Kannan N, Kornev AP, Allison CJ, Taylor SS. A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1. Protein Sci. 2009 Jul; 18(7):1486-97. PMID: 19530248; PMCID: PMC2775216.
    39. Kornev AP, Taylor SS. Pseudokinases: functional insights gleaned from structure. Structure. 2009 Jan 14; 17(1):5-7. PMID: 19141276.
      View in: PubMed
    40. Kornev AP, Taylor SS, Ten Eyck LF. A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14377-82. PMID: 18787129; PMCID: PMC2533684.
    41. Kornev AP, Taylor SS, Ten Eyck LF. A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol. 2008 Apr 11; 4(4):e1000056. PMID: 18404204; PMCID: PMC2275311.
    42. Ten Eyck LF, Taylor SS, Kornev AP. Conserved spatial patterns across the protein kinase family. Biochim Biophys Acta. 2008 Jan; 1784(1):238-43. PMID: 18067871.
      View in: PubMed
    43. Kornev AP, Haste NM, Taylor SS, Eyck LF. Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17783-8. PMID: 17095602; PMCID: PMC1693824.
    44. Berman HM, Ten Eyck LF, Goodsell DS, Haste NM, Kornev A, Taylor SS. The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):45-50. PMID: 15618393; PMCID: PMC544069.
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