Alexandr Kornev

Title(s)Project Scientist, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop. bioRxiv. 2023 Oct 16. Wu J, Jonniya NA, Hirakis SP, Olivieri C, Veglia G, Kornev AP, Taylor SS. PMID: 37693538; PMCID: PMC10491255.
      View in: PubMed   Mentions:
    2. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. Biochem J. 2023 08 30; 480(16):1299-1316. Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. PMID: 37551632; PMCID: PMC10586763.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. bioRxiv. 2023 Mar 16. Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. PMID: 36993163; PMCID: PMC10055082.
      View in: PubMed   Mentions:
    4. The "violin model": Looking at community networks for dynamic allostery. J Chem Phys. 2023 Feb 28; 158(8):081001. Madan LK, Welsh CL, Kornev AP, Taylor SS. PMID: 36859094; PMCID: PMC9957607.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Calculation of centralities in protein kinase A. Proc Natl Acad Sci U S A. 2022 11 22; 119(47):e2215420119. Kornev AP, Aoto PC, Taylor SS. PMID: 36375071; PMCID: PMC9704751.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    6. Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition. Sci Signal. 2022 Sep 27; 15(753):eabk1147. Pilo CA, Baffi TR, Kornev AP, Kunkel MT, Malfavon M, Chen DH, Rossitto LA, Chen DX, Huang LC, Longman C, Kannan N, Raskind WH, Gonzalez DJ, Taylor SS, Gorrie G, Newton AC. PMID: 36166510; PMCID: PMC9810342.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. From structure to the dynamic regulation of a molecular switch: A journey over 3 decades. J Biol Chem. 2021 Jan-Jun; 296:100746. Taylor SS, Wu J, Bruystens JGH, Del Rio JC, Lu TW, Kornev AP, Ten Eyck LF. PMID: 33957122; PMCID: PMC8144671.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    8. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 04 13; 14(678). Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. PMID: 33850054; PMCID: PMC8208635.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    9. Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes. IUBMB Life. 2020 12; 72(12):2584-2590. Jones AC, Taylor SS, Newton AC, Kornev AP. PMID: 33166426; PMCID: PMC8086893.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure. Hum Mutat. 2020 03; 41(3):619-631. Rodríguez Cruz PM, Cossins J, Cheung J, Maxwell S, Jayawant S, Herbst R, Waithe D, Kornev AP, Palace J, Beeson D. PMID: 31765060; PMCID: PMC7028094.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):14979-14988. Schmidt SH, Knape MJ, Boassa D, Mumdey N, Kornev AP, Ellisman MH, Taylor SS, Herberg FW. PMID: 31292254; PMCID: PMC6660771.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    12. Dynamic allostery-based molecular workings of kinase:peptide complexes. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15052-15061. Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS. PMID: 31285328; PMCID: PMC6660753.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    13. Tuning the "violin" of protein kinases: The role of dynamics-based allostery. IUBMB Life. 2019 06; 71(6):685-696. Ahuja LG, Taylor SS, Kornev AP. PMID: 31063633; PMCID: PMC6690483.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    14. Evolution of a dynamic molecular switch. IUBMB Life. 2019 06; 71(6):672-684. Taylor SS, Meharena HS, Kornev AP. PMID: 31059206; PMCID: PMC6690480.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    15. Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores. Trends Biochem Sci. 2019 04; 44(4):300-311. Gógl G, Kornev AP, Reményi A, Taylor SS. PMID: 30611608; PMCID: PMC6592696.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    16. Corrigendum to "A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation." J. Mol. Biol. 430(6) (Mar 16 2018), 881-889. J Mol Biol. 2018 Oct 19; 430(21):4439. Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. PMID: 30220583.
      View in: PubMed   Mentions: 2     Fields:    
    17. Self-organization, entropy and allostery. Biochem Soc Trans. 2018 06 19; 46(3):587-597. Kornev AP. PMID: 29678954; PMCID: PMC6503671.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    18. A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation. J Mol Biol. 2018 03 16; 430(6):881-889. Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. PMID: 29410316; PMCID: PMC6279248.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    19. Divalent metal ions control activity and inhibition of protein kinases. Metallomics. 2017 11 15; 9(11):1576-1584. Knape MJ, Ballez M, Burghardt NC, Zimmermann B, Bertinetti D, Kornev AP, Herberg FW. PMID: 29043344.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    20. A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv. 2017 Apr; 3(4):e1600663. Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor SS, Veglia G. PMID: 28435869; PMCID: PMC5384802.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    21. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα. Biochemistry. 2017 03 14; 56(10):1536-1545. P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor SS, Amaro RE. PMID: 28221775; PMCID: PMC5495472.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    22. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):E931-E940. Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS. PMID: 28115705; PMCID: PMC5307475.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    23. Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci. 2015 Nov; 40(11):628-647. Kornev AP, Taylor SS. PMID: 26481499; PMCID: PMC4630092.
      View in: PubMed   Mentions: 103     Fields:    Translation:Cells
    24. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Rep. 2015 Aug 25; 12(8):1252-60. Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. PMID: 26279568; PMCID: PMC4551583.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    25. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-1572. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS. PMID: 26278174; PMCID: PMC4558360.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    26. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nat Commun. 2015 Jul 06; 6:7588. Malmstrom RD, Kornev AP, Taylor SS, Amaro RE. PMID: 26145448; PMCID: PMC4504738.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    27. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015 Jun 01; 7(2):227-238. Zhang P, Kornev AP, Wu J, Taylor SS. PMID: 26097522; PMCID: PMC4469037.
      View in: PubMed   Mentions: 9  
    28. Integration of signaling in the kinome: Architecture and regulation of the αC Helix. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1567-74. Taylor SS, Shaw AS, Kannan N, Kornev AP. PMID: 25891902; PMCID: PMC4577442.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. PMID: 25348715; PMCID: PMC4295384.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    30. Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4623-31. McClendon CL, Kornev AP, Gilson MK, Taylor SS. PMID: 25319261; PMCID: PMC4217441.
      View in: PubMed   Mentions: 102     Fields:    Translation:Cells
    31. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding. J Biol Chem. 2014 Oct 24; 289(43):30040-51. Boras BW, Kornev A, Taylor SS, McCulloch AD. PMID: 25202018; PMCID: PMC4208011.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    32. Kinases and pseudokinases: lessons from RAF. Mol Cell Biol. 2014 May; 34(9):1538-46. Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. PMID: 24567368; PMCID: PMC3993607.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    33. PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure. 2014 Jan 07; 22(1):59-69. Bruystens JG, Wu J, Fortezzo A, Kornev AP, Blumenthal DK, Taylor SS. PMID: 24316401; PMCID: PMC3963464.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    34. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol. 2013 Oct; 11(10):e1001680. Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS, Kornev AP. PMID: 24143133; PMCID: PMC3797032.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    35. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013 Aug 29; 154(5):1036-1046. Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS. PMID: 23993095; PMCID: PMC3844432.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    36. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013 Aug; 41(4):981-6. Taylor SS, Shaw A, Hu J, Meharena HS, Kornev A. PMID: 23863167; PMCID: PMC4399968.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    37. PKA: lessons learned after twenty years. Biochim Biophys Acta. 2013 Jul; 1834(7):1271-8. Taylor SS, Zhang P, Steichen JM, Keshwani MM, Kornev AP. PMID: 23535202; PMCID: PMC3763834.
      View in: PubMed   Mentions: 133     Fields:    Translation:Cells
    38. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012 Oct; 13(10):646-58. Taylor SS, Ilouz R, Zhang P, Kornev AP. PMID: 22992589; PMCID: PMC3985763.
      View in: PubMed   Mentions: 213     Fields:    Translation:Cells
    39. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2517-28. Taylor SS, Keshwani MM, Steichen JM, Kornev AP. PMID: 22889904; PMCID: PMC3415842.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    40. Localization and quaternary structure of the PKA RIβ holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12443-8. Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor SS. PMID: 22797896; PMCID: PMC3411989.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    41. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor SS. PMID: 22493239; PMCID: PMC3356610.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    42. Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science. 2012 Feb 10; 335(6069):712-6. Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor SS. PMID: 22323819; PMCID: PMC3985767.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    43. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol. 2012 Jan 27; 415(4):666-79. Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor SS. PMID: 22138346; PMCID: PMC3445030.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    44. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure. 2011 Sep 07; 19(9):1317-27. Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL, Kornev AP, Taylor SS, Dostmann WR. PMID: 21893290; PMCID: PMC3168983.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    45. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6067-72. Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS. PMID: 21441104; PMCID: PMC3076888.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    46. Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. Structure. 2011 Feb 09; 19(2):265-76. Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor SS. PMID: 21300294; PMCID: PMC3097484.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    47. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci. 2011 Feb; 36(2):65-77. Taylor SS, Kornev AP. PMID: 20971646; PMCID: PMC3084033.
      View in: PubMed   Mentions: 414     Fields:    Translation:HumansAnimalsCells
    48. Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol. 2010 Nov; 6(11):821-8. Masterson LR, Cheng C, Yu T, Tonelli M, Kornev A, Taylor SS, Veglia G. PMID: 20890288; PMCID: PMC3487389.
      View in: PubMed   Mentions: 107     Fields:    Translation:Cells
    49. Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha. Protein Sci. 2010 Jun; 19(6):1213-21. Sjoberg TJ, Kornev AP, Taylor SS. PMID: 20512974; PMCID: PMC2895245.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    50. Yet another "active" pseudokinase, Erb3. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8047-8. Taylor SS, Kornev AP. PMID: 20421461; PMCID: PMC2889589.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    51. Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Mol Cell Proteomics. 2010 Oct; 9(10):2225-37. Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor SS, Johnson DA. PMID: 20167947; PMCID: PMC2957725.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    52. Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta. 2010 Mar; 1804(3):440-4. Kornev AP, Taylor SS. PMID: 19879387; PMCID: PMC3435107.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    53. Comparative surface geometry of the protein kinase family. Protein Sci. 2009 Oct; 18(10):2016-26. Thompson EE, Kornev AP, Kannan N, Kim C, Ten Eyck LF, Taylor SS. PMID: 19610074; PMCID: PMC2786965.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    54. A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1. Protein Sci. 2009 Jul; 18(7):1486-97. Romano RA, Kannan N, Kornev AP, Allison CJ, Taylor SS. PMID: 19530248; PMCID: PMC2775216.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    55. Pseudokinases: functional insights gleaned from structure. Structure. 2009 Jan 14; 17(1):5-7. Kornev AP, Taylor SS. PMID: 19141276; PMCID: PMC6226308.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    56. A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14377-82. Kornev AP, Taylor SS, Ten Eyck LF. PMID: 18787129; PMCID: PMC2533684.
      View in: PubMed   Mentions: 201     Fields:    Translation:Cells
    57. A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol. 2008 Apr 11; 4(4):e1000056. Kornev AP, Taylor SS, Ten Eyck LF. PMID: 18404204; PMCID: PMC2275311.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    58. Conserved spatial patterns across the protein kinase family. Biochim Biophys Acta. 2008 Jan; 1784(1):238-43. Ten Eyck LF, Taylor SS, Kornev AP. PMID: 18067871.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    59. Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17783-8. Kornev AP, Haste NM, Taylor SS, Eyck LF. PMID: 17095602; PMCID: PMC1693824.
      View in: PubMed   Mentions: 328     Fields:    Translation:HumansCells
    60. The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):45-50. Berman HM, Ten Eyck LF, Goodsell DS, Haste NM, Kornev A, Taylor SS. PMID: 15618393; PMCID: PMC544069.
      View in: PubMed   Mentions: 105     Fields:    Translation:Cells
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