Hiruy Meharena

Title(s)Assistant Professor, Neurobiology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration. Cell. 2023 09 28; 186(20):4404-4421.e20. Dileep V, Boix CA, Mathys H, Marco A, Welch GM, Meharena HS, Loon A, Jeloka R, Peng Z, Bennett DA, Kellis M, Tsai LH. PMID: 37774679; PMCID: PMC10697236.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    2. From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome. Front Genet. 2023; 14:1198129. Watson LA, Meharena HS. PMID: 37323671; PMCID: PMC10267712.
      View in: PubMed   Mentions:
    3. Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity. Cell Stem Cell. 2022 08 04; 29(8):1197-1212.e8. Victor MB, Leary N, Luna X, Meharena HS, Scannail AN, Bozzelli PL, Samaan G, Murdock MH, von Maydell D, Effenberger AH, Cerit O, Wen HL, Liu L, Welch G, Bonner M, Tsai LH. PMID: 35931030; PMCID: PMC9623845.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    4. Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors. Cell Stem Cell. 2022 01 06; 29(1):116-130.e7. Meharena HS, Marco A, Dileep V, Lockshin ER, Akatsu GY, Mullahoo J, Watson LA, Ko T, Guerin LN, Abdurrob F, Rengarajan S, Papanastasiou M, Jaffe JD, Tsai LH. PMID: 34995493; PMCID: PMC8805993.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    5. Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble. Nat Neurosci. 2020 12; 23(12):1606-1617. Marco A, Meharena HS, Dileep V, Raju RM, Davila-Velderrain J, Zhang AL, Adaikkan C, Young JZ, Gao F, Kellis M, Tsai LH. PMID: 33020654; PMCID: PMC7686266.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    6. Evolution of a dynamic molecular switch. IUBMB Life. 2019 06; 71(6):672-684. Taylor SS, Meharena HS, Kornev AP. PMID: 31059206; PMCID: PMC6690480.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    7. Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. PLoS Biol. 2016 Nov; 14(11):e2000127. Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA, Taylor SS. PMID: 27902690; PMCID: PMC5130182.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    8. Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. PLoS One. 2015; 10(8):e0136605. Pence MA, Haste NM, Meharena HS, Olson J, Gallo RL, Nizet V, Kristian SA. PMID: 26305782; PMCID: PMC4549145.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    9. A solo luxI-type gene directs acylhomoserine lactone synthesis and contributes to motility control in the marine sponge symbiont Ruegeria sp. KLH11. Microbiology (Reading). 2015 Jan; 161(Pt 1):50-56. Zan J, Choi O, Meharena H, Uhlson CL, Churchill MEA, Hill RT, Fuqua C. PMID: 25355937; PMCID: PMC4811643.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. PMID: 25348715; PMCID: PMC4295384.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    11. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol. 2013 Oct; 11(10):e1001680. Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS, Kornev AP. PMID: 24143133; PMCID: PMC3797032.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    12. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013 Aug 29; 154(5):1036-1046. Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS. PMID: 23993095; PMCID: PMC3844432.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansAnimalsCells
    13. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013 Aug; 41(4):981-6. Taylor SS, Shaw A, Hu J, Meharena HS, Kornev A. PMID: 23863167; PMCID: PMC4399968.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
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