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Steven Silletti

Title(s)Assistant Professor, Chemistry and Biochemistry
SchoolAcademic Aff
Phone858-822-0032
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    Collapse Research 
    Collapse Research Activities and Funding
    Traget-Driven Identification of Diagnostic Patterns in Pancreatic Adenocarcinoma
    NIH/NCI R03CA130104Jul 12, 2007 - Jun 30, 2010
    Role: Principal Investigator
    Potential Role of pp72syk in Pancreatic Adenocarcinoma
    NIH/NCI R03CA109956Aug 1, 2004 - Jul 31, 2006
    Role: Principal Investigator
    SIGNALING POTENTIATION OF BREAST CANCER ANGIOGENESIS
    NIH/NCI F32CA072192Jul 1, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee CY, Marzan D, Lin G, Goodison S, Silletti S. a2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5. J Oncol. 2011; 2011:365651. PMID: 22203845.
      View in: PubMed
    2. Chen MM, Lee CY, Leland HA, Silletti S. Modification of the L1-CAM carboxy-terminus in pancreatic adenocarcinoma cells. Tumour Biol. 2011 Apr; 32(2):347-57. PMID: 21080252.
      View in: PubMed
    3. Chen MM, Lee CY, Leland HA, Lin GY, Montgomery AM, Silletti S. Inside-out regulation of L1 conformation, integrin binding, proteolysis, and concomitant cell migration. Mol Biol Cell. 2010 May 15; 21(10):1671-85. PMID: 20335502.
      View in: PubMed
    4. Layton T, Stalens C, Gunderson F, Goodison S, Silletti S. Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion. Am J Pathol. 2009 Dec; 175(6):2625-36. PMID: 19893036.
      View in: PubMed
    5. Chen MM, Leland HA, Lee CY, Silletti S. Tyrosine and serine phosphorylation regulate the conformation and subsequent threonine phosphorylation of the L1 cytoplasmic domain. Biochem Biophys Res Commun. 2009 Nov 13; 389(2):257-64. PMID: 19720049.
      View in: PubMed
    6. Grzesiak JJ, Clopton P, Chalberg C, Smith K, Burton DW, Silletti S, Moossa AR, Deftos LJ, Bouvet M. The extracellular matrix differentially regulates the expression of PTHrP and the PTH/PTHrP receptor in FG pancreatic cancer cells. Pancreas. 2004 Aug; 29(2):85-92. PMID: 15257098.
      View in: PubMed
    7. Silletti S, Yebra M, Perez B, Cirulli V, McMahon M, Montgomery AM. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem. 2004 Jul 09; 279(28):28880-8. PMID: 15128735.
      View in: PubMed
    8. Yebra M, Montgomery AM, Diaferia GR, Kaido T, Silletti S, Perez B, Just ML, Hildbrand S, Hurford R, Florkiewicz E, Tessier-Lavigne M, Cirulli V. Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell. 2003 Nov; 5(5):695-707. PMID: 14602071.
      View in: PubMed
    9. Silletti S, Mei F, Sheppard D, Montgomery AM. Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment. J Cell Biol. 2000 Jun 26; 149(7):1485-502. PMID: 10871287.
      View in: PubMed
    10. Stupack DG, Li E, Silletti SA, Kehler JA, Geahlen RL, Hahn K, Nemerow GR, Cheresh DA. Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol. 1999 Feb 22; 144(4):777-88. PMID: 10037798; PMCID: PMC2132930.