Steven Silletti

Title(s), Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Traget-Driven Identification of Diagnostic Patterns in Pancreatic Adenocarcinoma
    NIH R03CA130104Jul 12, 2007 - Jun 30, 2010
    Role: Principal Investigator
    Potential Role of pp72syk in Pancreatic Adenocarcinoma
    NIH R03CA109956Aug 1, 2004 - Jul 31, 2006
    Role: Principal Investigator
    SIGNALING POTENTIATION OF BREAST CANCER ANGIOGENESIS
    NIH F32CA072192Jul 1, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Res Sq. 2024 Feb 23. Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. PMID: 38464189; PMCID: PMC10925425.
      View in: PubMed   Mentions:
    2. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. bioRxiv. 2024 Jan 23. Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. PMID: 38260668; PMCID: PMC10802581.
      View in: PubMed   Mentions:
    3. Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors. ACS Chem Biol. 2023 04 21; 18(4):810-821. Weng JH, Ma W, Wu J, Sharma PK, Silletti S, McCammon JA, Taylor S. PMID: 37043829; PMCID: PMC10127209.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    4. Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry. Biochemistry. 2023 03 21; 62(6):1145-1159. Sabo KA, Albekioni E, Caliger D, Coleman NJ, Thornberg E, Avellaneda Matteo D, Komives EA, Silletti S, Sohl CD. PMID: 36854124; PMCID: PMC10089636.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release. Elife. 2022 05 31; 11. Bibel B, Elkayam E, Silletti S, Komives EA, Joshua-Tor L. PMID: 35638597; PMCID: PMC9154749.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. PLoS Biol. 2022 02; 20(2):e3001427. Weng JH, Aoto PC, Lorenz R, Wu J, Schmidt SH, Manschwetus JT, Kaila-Sharma P, Silletti S, Mathea S, Chatterjee D, Knapp S, Herberg FW, Taylor SS. PMID: 35192607; PMCID: PMC8863276.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    7. Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Schmidt SH, Weng JH, Aoto PC, Boassa D, Mathea S, Silletti S, Hu J, Wallbott M, Komives EA, Knapp S, Herberg FW, Taylor SS. PMID: 34088839; PMCID: PMC8201809.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    8. Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein. Protein Sci. 2020 09; 29(9):1890-1901. Ye Q, West AMV, Silletti S, Corbett KD. PMID: 32654247; PMCID: PMC7405475.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    9. Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein. bioRxiv. 2020 Jun 08. Ye Q, West AMV, Silletti S, Corbett KD. PMID: 32511359; PMCID: PMC7263487.
      View in: PubMed   Mentions:
    10. Differential Local Stability Governs the Metamorphic Fold Switch of Bacterial Virulence Factor RfaH. Biophys J. 2020 01 07; 118(1):96-104. Galaz-Davison P, Molina JA, Silletti S, Komives EA, Knauer SH, Artsimovitch I, Ramírez-Sarmiento CA. PMID: 31810657; PMCID: PMC6950767.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    11. α2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5. J Oncol. 2011; 2011:365651. Lee CY, Marzan D, Lin G, Goodison S, Silletti S. PMID: 22203845; PMCID: PMC3245846.
      View in: PubMed   Mentions: 5  
    12. Modification of the L1-CAM carboxy-terminus in pancreatic adenocarcinoma cells. Tumour Biol. 2011 Apr; 32(2):347-57. Chen MM, Lee CY, Leland HA, Silletti S. PMID: 21080252; PMCID: PMC3041914.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Inside-out regulation of L1 conformation, integrin binding, proteolysis, and concomitant cell migration. Mol Biol Cell. 2010 May 15; 21(10):1671-85. Chen MM, Lee CY, Leland HA, Lin GY, Montgomery AM, Silletti S. PMID: 20335502; PMCID: PMC2869374.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    14. Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion. Am J Pathol. 2009 Dec; 175(6):2625-36. Layton T, Stalens C, Gunderson F, Goodison S, Silletti S. PMID: 19893036; PMCID: PMC2789622.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    15. Tyrosine and serine phosphorylation regulate the conformation and subsequent threonine phosphorylation of the L1 cytoplasmic domain. Biochem Biophys Res Commun. 2009 Nov 13; 389(2):257-64. Chen MM, Leland HA, Lee CY, Silletti S. PMID: 19720049; PMCID: PMC2770334.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. The extracellular matrix differentially regulates the expression of PTHrP and the PTH/PTHrP receptor in FG pancreatic cancer cells. Pancreas. 2004 Aug; 29(2):85-92. Grzesiak JJ, Clopton P, Chalberg C, Smith K, Burton DW, Silletti S, Moossa AR, Deftos LJ, Bouvet M. PMID: 15257098.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem. 2004 Jul 09; 279(28):28880-8. Silletti S, Yebra M, Perez B, Cirulli V, McMahon M, Montgomery AM. PMID: 15128735.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    18. Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell. 2003 Nov; 5(5):695-707. Yebra M, Montgomery AM, Diaferia GR, Kaido T, Silletti S, Perez B, Just ML, Hildbrand S, Hurford R, Florkiewicz E, Tessier-Lavigne M, Cirulli V. PMID: 14602071.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    19. Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment. J Cell Biol. 2000 Jun 26; 149(7):1485-502. Silletti S, Mei F, Sheppard D, Montgomery AM. PMID: 10871287; PMCID: PMC2175144.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    20. Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol. 1999 Feb 22; 144(4):777-88. Stupack DG, Li E, Silletti SA, Kehler JA, Geahlen RL, Hahn K, Nemerow GR, Cheresh DA. PMID: 10037798; PMCID: PMC2132930.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
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