Albert Chen

Title(s)Project Scientist, Bioengineering
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    1. Impact insertion of osteochondral grafts: Interference fit and central graft reduction affect biomechanics and cartilage damage. J Orthop Res. 2018 01; 36(1):377-386. Su AW, Chen Y, Wailes DH, Wong VW, Cai S, Chen AC, Bugbee WD, Sah RL. PMID: 28682003.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    2. Ex vivo loading of trussed implants for spine fusion induces heterogeneous strains consistent with homeostatic bone mechanobiology. J Biomech. 2016 12 08; 49(16):4090-4097. Caffrey JP, Cory E, Wong VW, Masuda K, Chen AC, Hunt JP, Ganey TM, Sah RL. PMID: 27836500.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. Arthritis Res Ther. 2016 Jan 21; 18:18. Temple-Wong MM, Ren S, Quach P, Hansen BC, Chen AC, Hasegawa A, D'Lima DD, Koziol J, Masuda K, Lotz MK, Sah RL, Temple-Wong MM, Ren S, Quach P, Hansen BC, Chen AC, Hasegawa A, D'Lima DD, Koziol J, Masuda K, Lotz MK, Sah RL. PMID: 26792492; PMCID: PMC4721052.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    4. Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects: Does It Enhance Repair? J Bone Joint Surg Am. 2016 Jan 06; 98(1):23-34. Goodrich LR, Chen AC, Werpy NM, Williams AA, Kisiday JD, Su AW, Cory E, Morley PS, McIlwraith CW, Sah RL, Chu CR, Goodrich LR, Chen AC, Werpy NM, Williams AA, Kisiday JD, Su AW, Cory E, Morley PS, McIlwraith CW, Sah RL, Chu CR. PMID: 26738900; PMCID: PMC4697360.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    5. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J, Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J. PMID: 25893917; PMCID: PMC4452027.
      View in: PubMed   Mentions: 252     Fields:    Translation:HumansAnimalsCells
    6. Mechanical evaluation of a tissue-engineered zone of calcification in a bone-hydrogel osteochondral construct. Comput Methods Biomech Biomed Engin. 2015; 18(3):332-7. Hollenstein J, Terrier A, Cory E, Chen AC, Sah RL, Pioletti DP, Hollenstein J, Terrier A, Cory E, Chen AC, Sah RL, Pioletti DP. PMID: 23706035; PMCID: PMC4732526.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. In vivo efficacy of fresh versus frozen osteochondral allografts in the goat at 6 months is associated with PRG4 secretion. J Orthop Res. 2013 Jun; 31(6):880-6. Pallante-Kichura AL, Chen AC, Temple-Wong MM, Bugbee WD, Sah RL, Pallante-Kichura AL, Chen AC, Temple-Wong MM, Bugbee WD, Sah RL. PMID: 23362152; PMCID: PMC4076778.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens. PLoS One. 2012; 7(11):e48734. Gokhin DS, Nowak RB, Kim NE, Arnett EE, Chen AC, Sah RL, Clark JI, Fowler VM, Gokhin DS, Nowak RB, Kim NE, Arnett EE, Chen AC, Sah RL, Clark JI, Fowler VM. PMID: 23144950; PMCID: PMC3492431.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    9. Treatment of articular cartilage defects in the goat with frozen versus fresh osteochondral allografts: effects on cartilage stiffness, zonal composition, and structure at six months. J Bone Joint Surg Am. 2012 Nov 07; 94(21):1984-95. Pallante AL, Görtz S, Chen AC, Healey RM, Chase DC, Ball ST, Amiel D, Sah RL, Bugbee WD, Pallante AL, Görtz S, Chen AC, Healey RM, Chase DC, Ball ST, Amiel D, Sah RL, Bugbee WD. PMID: 23138239; PMCID: PMC3489067.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    10. Association of 3-Dimensional Cartilage and Bone Structure with Articular Cartilage Properties in and Adjacent to Autologous Osteochondral Grafts after 6 and 12 months in a Goat Model. Cartilage. 2012 Jul 01; 3(3). Chan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG, Sah RL, Chan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG, Sah RL. PMID: 24224069; PMCID: PMC3818730.
      View in: PubMed   Mentions: 8     Fields:    
    11. Cartilage-like mechanical properties of poly (ethylene glycol)-diacrylate hydrogels. Biomaterials. 2012 Oct; 33(28):6682-90. Nguyen QT, Hwang Y, Chen AC, Varghese S, Sah RL, Nguyen QT, Hwang Y, Chen AC, Varghese S, Sah RL. PMID: 22749448; PMCID: PMC3572364.
      View in: PubMed   Mentions: 34     Fields:    
    12. The in vivo performance of osteochondral allografts in the goat is diminished with extended storage and decreased cartilage cellularity. Am J Sports Med. 2012 Aug; 40(8):1814-23. Pallante AL, Chen AC, Ball ST, Amiel D, Masuda K, Sah RL, Bugbee WD, Pallante AL, Chen AC, Ball ST, Amiel D, Masuda K, Sah RL, Bugbee WD. PMID: 22707746; PMCID: PMC4041579.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    13. Compaction enhances extracellular matrix content and mechanical properties of tissue-engineered cartilaginous constructs. Tissue Eng Part A. 2012 Jun; 18(11-12):1151-60. Han EH, Ge C, Chen AC, Schumacher BL, Sah RL, Han EH, Ge C, Chen AC, Schumacher BL, Sah RL. PMID: 22372815; PMCID: PMC3360506.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. In vitro articular cartilage growth with sequential application of IGF-1 and TGF-β1 enhances volumetric growth and maintains compressive properties. J Biomech Eng. 2012 Mar; 134(3):031001. Balcom NT, Berg-Johansen B, Dills KJ, Van Donk JR, Williams GM, Chen AC, Hazelwood SJ, Sah RL, Klisch SM, Balcom NT, Berg-Johansen B, Dills KJ, Van Donk JR, Williams GM, Chen AC, Hazelwood SJ, Sah RL, Klisch SM. PMID: 22482681; PMCID: PMC3689422.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    15. Effect of initial cell seeding density on 3D-engineered silk fibroin scaffolds for articular cartilage tissue engineering. Biomaterials. 2011 Dec; 32(34):8927-37. Talukdar S, Nguyen QT, Chen AC, Sah RL, Kundu SC, Talukdar S, Nguyen QT, Chen AC, Sah RL, Kundu SC. PMID: 21906805; PMCID: PMC3183393.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    16. Potential of 3-D tissue constructs engineered from bovine chondrocytes/silk fibroin-chitosan for in vitro cartilage tissue engineering. Biomaterials. 2011 Sep; 32(25):5773-81. Bhardwaj N, Nguyen QT, Chen AC, Kaplan DL, Sah RL, Kundu SC, Bhardwaj N, Nguyen QT, Chen AC, Kaplan DL, Sah RL, Kundu SC. PMID: 21601277; PMCID: PMC3110545.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    17. Insulin-like growth factor-I and growth differentiation factor-5 promote the formation of tissue-engineered human nasal septal cartilage. Tissue Eng Part C Methods. 2010 Oct; 16(5):1213-21. Alexander TH, Sage AB, Chen AC, Schumacher BL, Shelton E, Masuda K, Sah RL, Watson D, Alexander TH, Sage AB, Chen AC, Schumacher BL, Shelton E, Masuda K, Sah RL, Watson D. PMID: 20178406; PMCID: PMC2943402.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Tissue engineering by molecular disassembly and reassembly: biomimetic retention of mechanically functional aggrecan in hydrogel. Tissue Eng Part C Methods. 2010 Dec; 16(6):1471-9. Han EH, Wilensky LM, Schumacher BL, Chen AC, Masuda K, Sah RL, Han EH, Wilensky LM, Schumacher BL, Chen AC, Masuda K, Sah RL. PMID: 20486781; PMCID: PMC2988632.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    19. Differential regulation of immature articular cartilage compressive moduli and Poisson's ratios by in vitro stimulation with IGF-1 and TGF-beta1. J Biomech. 2010 Sep 17; 43(13):2501-7. Williams GM, Dills KJ, Flores CR, Stender ME, Stewart KM, Nelson LM, Chen AC, Masuda K, Hazelwood SJ, Klisch SM, Sah RL, Williams GM, Dills KJ, Flores CR, Stender ME, Stewart KM, Nelson LM, Chen AC, Masuda K, Hazelwood SJ, Klisch SM, Sah RL. PMID: 20570267; PMCID: PMC2937078.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    20. Can osteochondral grafting be augmented with microfracture in an extended-size lesion of articular cartilage? Am J Sports Med. 2010 Jul; 38(7):1316-23. Lane JG, Healey RM, Chen AC, Sah RL, Amiel D, Lane JG, Healey RM, Chen AC, Sah RL, Amiel D. PMID: 20400750; PMCID: PMC4111625.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    21. Topographic Patterns of Cartilage Lesions in Knee Osteoarthritis. Cartilage. 2010 Jan; 1(1):10-19. Bae WC, Payanal MM, Chen AC, Hsieh-Bonassera ND, Ballard BL, Lotz MK, Coutts RD, Bugbee WD, Sah RL, Bae WC, Payanal MM, Chen AC, Hsieh-Bonassera ND, Ballard BL, Lotz MK, Coutts RD, Bugbee WD, Sah RL. PMID: 20664706; PMCID: PMC2909594.
      View in: PubMed   Mentions: 11     Fields:    
    22. Expansion and redifferentiation of chondrocytes from osteoarthritic cartilage: cells for human cartilage tissue engineering. Tissue Eng Part A. 2009 Nov; 15(11):3513-23. Hsieh-Bonassera ND, Wu I, Lin JK, Schumacher BL, Chen AC, Masuda K, Bugbee WD, Sah RL, Hsieh-Bonassera ND, Wu I, Lin JK, Schumacher BL, Chen AC, Masuda K, Bugbee WD, Sah RL. PMID: 19456239; PMCID: PMC2792054.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    23. Chondrocyte viability is higher after prolonged storage at 37 degrees C than at 4 degrees C for osteochondral grafts. Am J Sports Med. 2009 Nov; 37 Suppl 1:24S-32S. Pallante AL, Bae WC, Chen AC, Görtz S, Bugbee WD, Sah RL, Pallante AL, Bae WC, Chen AC, Görtz S, Bugbee WD, Sah RL. PMID: 19861697; PMCID: PMC2858049.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    24. Articular cartilage mechanical and biochemical property relations before and after in vitro growth. J Biomech. 2007; 40(16):3607-14. Ficklin T, Thomas G, Barthel JC, Asanbaeva A, Thonar EJ, Masuda K, Chen AC, Sah RL, Davol A, Klisch SM, Ficklin T, Thomas G, Barthel JC, Asanbaeva A, Thonar EJ, Masuda K, Chen AC, Sah RL, Davol A, Klisch SM. PMID: 17628568; PMCID: PMC2175072.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    25. Short-term retention of labeled chondrocyte subpopulations in stratified tissue-engineered cartilaginous constructs implanted in vivo in mini-pigs. Tissue Eng. 2007 Jul; 13(7):1525-37. Chawla K, Klein TJ, Schumacher BL, Jadin KD, Shah BH, Nakagawa K, Wong VW, Chen AC, Masuda K, Sah RL, Chawla K, Klein TJ, Schumacher BL, Jadin KD, Shah BH, Nakagawa K, Wong VW, Chen AC, Masuda K, Sah RL. PMID: 17532744.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    26. Compressive biomechanical properties of human nasal septal cartilage. Am J Rhinol. 2006 Sep-Oct; 20(5):496-501. Richmon JD, Sage A, Wong WV, Chen AC, Sah RL, Watson D, Watston D, Richmon JD, Sage A, Wong WV, Chen AC, Sah RL, Watson D, Watston D. PMID: 17063745.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    27. Effect of impact on chondrocyte viability during insertion of human osteochondral grafts. J Bone Joint Surg Am. 2006 Sep; 88(9):1934-43. Borazjani BH, Chen AC, Bae WC, Patil S, Sah RL, Firestein GS, Bugbee WD, Borazjani BH, Chen AC, Bae WC, Patil S, Sah RL, Firestein GS, Bugbee WD. PMID: 16951108.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    28. Tensile biomechanical properties of human nasal septal cartilage. Am J Rhinol. 2005 Nov-Dec; 19(6):617-22. Richmon JD, Sage AB, Wong VW, Chen AC, Pan C, Sah RL, Watson D, Richmon JD, Sage AB, Wong VW, Chen AC, Pan C, Sah RL, Watson D. PMID: 16402652.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    29. Evaluation of subchondral bone mineral density associated with articular cartilage structure and integrity in healthy equine joints with different functional demands. Am J Vet Res. 2005 Oct; 66(10):1823-9. Lewis CW, Williamson AK, Chen AC, Bae WC, Temple MM, Wong WV, Nugent GE, James SP, Wheeler DL, Sah RL, Kawcak CE, Lewis CW, Williamson AK, Chen AC, Bae WC, Temple MM, Wong WV, Nugent GE, James SP, Wheeler DL, Sah RL, Kawcak CE. PMID: 16273917.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    30. Analysis of stored osteochondral allografts at the time of surgical implantation. Am J Sports Med. 2005 Oct; 33(10):1479-84. Allen RT, Robertson CM, Pennock AT, Bugbee WD, Harwood FL, Wong VW, Chen AC, Sah RL, Amiel D, Allen RT, Robertson CM, Pennock AT, Bugbee WD, Harwood FL, Wong VW, Chen AC, Sah RL, Amiel D. PMID: 16009984.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    31. Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus. J Orthop Res. 2005 May; 23(3):562-8. Schumacher BL, Schmidt TA, Voegtline MS, Chen AC, Sah RL, Schumacher BL, Schmidt TA, Voegtline MS, Chen AC, Sah RL. PMID: 15885476.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    32. Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage. J Biomech. 2006; 39(1):138-46. Gratz KR, Wong VW, Chen AC, Fortier LA, Nixon AJ, Sah RL, Gratz KR, Wong VW, Chen AC, Fortier LA, Nixon AJ, Sah RL. PMID: 16271598.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    33. Site- and exercise-related variation in structure and function of cartilage from equine distal metacarpal condyle. Osteoarthritis Cartilage. 2004 Oct; 12(10):826-33. Nugent GE, Law AW, Wong EG, Temple MM, Bae WC, Chen AC, Kawcak CE, Sah RL, Nugent GE, Law AW, Wong EG, Temple MM, Bae WC, Chen AC, Kawcak CE, Sah RL. PMID: 15450533.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCTClinical Trials
    34. Follow-up of osteochondral plug transfers in a goat model: a 6-month study. Am J Sports Med. 2004 Sep; 32(6):1440-50. Lane JG, Massie JB, Ball ST, Amiel ME, Chen AC, Bae WC, Sah RL, Amiel D, Lane JG, Massie JB, Ball ST, Amiel ME, Chen AC, Bae WC, Sah RL, Amiel D. PMID: 15310569.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    35. The effects of storage on fresh human osteochondral allografts. Clin Orthop Relat Res. 2004 Jan; (418):246-52. Ball ST, Amiel D, Williams SK, Tontz W, Chen AC, Sah RL, Bugbee WD, Ball ST, Amiel D, Williams SK, Tontz W, Chen AC, Sah RL, Bugbee WD. PMID: 15043126.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    36. Mechanical characterization of native and tissue-engineered cartilage. Methods Mol Med. 2004; 101:157-90. Chen AC, Klisch SM, Bae WC, Temple MM, McGowan KB, Gratz KR, Schumacher BL, Sah RL, Chen AC, Klisch SM, Bae WC, Temple MM, McGowan KB, Gratz KR, Schumacher BL, Sah RL. PMID: 15299215.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    37. Prolonged storage effects on the articular cartilage of fresh human osteochondral allografts. J Bone Joint Surg Am. 2003 Nov; 85(11):2111-20. Williams SK, Amiel D, Ball ST, Allen RT, Wong VW, Chen AC, Sah RL, Bugbee WD, Williams SK, Amiel D, Ball ST, Allen RT, Wong VW, Chen AC, Sah RL, Bugbee WD. PMID: 14630839.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    38. Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res. 2003 Sep; 21(5):872-80. Williamson AK, Chen AC, Masuda K, Thonar EJ, Sah RL, Williamson AK, Chen AC, Masuda K, Thonar EJ, Sah RL. PMID: 12919876.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    39. Adhesion of perichondrial cells to a polylactic acid scaffold. J Orthop Res. 2003 Jul; 21(4):584-9. Giurea A, Klein TJ, Chen AC, Goomer RS, Coutts RD, Akeson WH, Amiel D, Sah RL, Giurea A, Klein TJ, Chen AC, Goomer RS, Coutts RD, Akeson WH, Amiel D, Sah RL. PMID: 12798055.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    40. Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage. Arthritis Rheum. 2002 Dec; 46(12):3212-7. Chen AC, Temple MM, Ng DM, Verzijl N, DeGroot J, TeKoppele JM, Sah RL, Chen AC, Temple MM, Ng DM, Verzijl N, DeGroot J, TeKoppele JM, Sah RL. PMID: 12483725.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    41. Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage. J Orthop Res. 2002 Jul; 20(4):842-8. Davisson T, Kunig S, Chen A, Sah R, Ratcliffe A, Davisson T, Kunig S, Chen A, Sah R, Ratcliffe A. PMID: 12168676.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
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