Albert Chen

TitleProject Scientist
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0412
La Jolla CA 92093
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    1. Su AW, Chen Y, Dong Y, Wailes DH, Wong VW, Chen A, Cai S, Bugbee WD, Sah RL. Biomechanics of osteochondral impact with cushioning and graft Insertion: Cartilage damage is correlated with delivered energy. J Biomech. 2018 May 17; 73:127-136. PMID: 29628132.
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    2. Su AW, Chen Y, Wailes DH, Wong VW, Cai S, Chen A, Bugbee WD, Sah RL. Impact insertion of osteochondral grafts: Interference fit and central graft reduction affect biomechanics and cartilage damage. J Orthop Res. 2018 Jan; 36(1):377-386. PMID: 28682003.
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    3. Sun Y, Jiang W, Cory E, Caffrey JP, Hsu FH, Chen A, Wang J, Sah RL, Bugbee WD. Pulsed lavage cleansing of osteochondral grafts depends on lavage duration, flow intensity, and graft storage condition. PLoS One. 2017; 12(5):e0176934. PMID: 28464040.
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    4. Chen A, Okcu MF, Dreyer ZE, Kamdar KY, Sonabend RY, Suzawa HS, Jo E, Paulino AC. Comparison of height and weight after 12 vs. 18 Gy cranial radiation therapy in pediatric acute lymphoblastic leukemia (ALL) patients. Adv Radiat Oncol. 2017 Apr-Jun; 2(2):228-234. PMID: 28740936.
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    5. Caffrey JP, Cory E, Wong VW, Masuda K, Chen A, Hunt JP, Ganey TM, Sah RL. Ex vivo loading of trussed implants for spine fusion induces heterogeneous strains consistent with homeostatic bone mechanobiology. J Biomech. 2016 12 08; 49(16):4090-4097. PMID: 27836500.
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    6. Temple-Wong MM, Ren S, Quach P, Hansen BC, Chen A, Hasegawa A, D'Lima DD, Koziol J, Masuda K, Lotz MK, Sah RL. Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. Arthritis Res Ther. 2016 Jan 21; 18:18. PMID: 26792492; PMCID: PMC4721052.
    7. Goodrich LR, Chen A, Werpy NM, Williams AA, Kisiday JD, Su AW, Cory E, Morley PS, McIlwraith CW, Sah RL, Chu CR. Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects: Does It Enhance Repair? J Bone Joint Surg Am. 2016 Jan 06; 98(1):23-34. PMID: 26738900; PMCID: PMC4697360 [Available on 01/06/17].
    8. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen A, Sah RL, Taylor SS, Engler AJ, Yang J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. PMID: 25893917; PMCID: PMC4452027.
    9. Hollenstein J, Terrier A, Cory E, Chen A, Sah RL, Pioletti DP. Mechanical evaluation of a tissue-engineered zone of calcification in a bone-hydrogel osteochondral construct. Comput Methods Biomech Biomed Engin. 2015; 18(3):332-7. PMID: 23706035; PMCID: PMC4732526.
    10. Pallante-Kichura AL, Chen A, Temple-Wong MM, Bugbee WD, Sah RL. In vivo efficacy of fresh versus frozen osteochondral allografts in the goat at 6 months is associated with PRG4 secretion. J Orthop Res. 2013 Jun; 31(6):880-6. PMID: 23362152; PMCID: PMC4076778.
    11. Gokhin DS, Nowak RB, Kim NE, Arnett EE, Chen A, Sah RL, Clark JI, Fowler VM. Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens. PLoS One. 2012; 7(11):e48734. PMID: 23144950; PMCID: PMC3492431.
    12. Pallante AL, Görtz S, Chen A, Healey RM, Chase DC, Ball ST, Amiel D, Sah RL, Bugbee WD. Treatment of articular cartilage defects in the goat with frozen versus fresh osteochondral allografts: effects on cartilage stiffness, zonal composition, and structure at six months. J Bone Joint Surg Am. 2012 Nov 07; 94(21):1984-95. PMID: 23138239; PMCID: PMC3489067.
    13. Chan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen A, Truncale KG, Sah RL. Association of 3-Dimensional Cartilage and Bone Structure with Articular Cartilage Properties in and Adjacent to Autologous Osteochondral Grafts after 6 and 12 months in a Goat Model. Cartilage. 2012 Jul 01; 3(3). PMID: 24224069.
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    14. Nguyen QT, Hwang Y, Chen A, Varghese S, Sah RL. Cartilage-like mechanical properties of poly (ethylene glycol)-diacrylate hydrogels. Biomaterials. 2012 Oct; 33(28):6682-90. PMID: 22749448; PMCID: PMC3572364.
    15. Pallante AL, Chen A, Ball ST, Amiel D, Masuda K, Sah RL, Bugbee WD. The in vivo performance of osteochondral allografts in the goat is diminished with extended storage and decreased cartilage cellularity. Am J Sports Med. 2012 Aug; 40(8):1814-23. PMID: 22707746; PMCID: PMC4041579.
    16. Han EH, Ge C, Chen A, Schumacher BL, Sah RL. Compaction enhances extracellular matrix content and mechanical properties of tissue-engineered cartilaginous constructs. Tissue Eng Part A. 2012 Jun; 18(11-12):1151-60. PMID: 22372815; PMCID: PMC3360506.
    17. Balcom NT, Berg-Johansen B, Dills KJ, Van Donk JR, Williams GM, Chen A, Hazelwood SJ, Sah RL, Klisch SM. In vitro articular cartilage growth with sequential application of IGF-1 and TGF-ß1 enhances volumetric growth and maintains compressive properties. J Biomech Eng. 2012 Mar; 134(3):031001. PMID: 22482681; PMCID: PMC3689422.
    18. Talukdar S, Nguyen QT, Chen A, Sah RL, Kundu SC. Effect of initial cell seeding density on 3D-engineered silk fibroin scaffolds for articular cartilage tissue engineering. Biomaterials. 2011 Dec; 32(34):8927-37. PMID: 21906805; PMCID: PMC3183393.
    19. Bhardwaj N, Nguyen QT, Chen A, Kaplan DL, Sah RL, Kundu SC. Potential of 3-D tissue constructs engineered from bovine chondrocytes/silk fibroin-chitosan for in vitro cartilage tissue engineering. Biomaterials. 2011 Sep; 32(25):5773-81. PMID: 21601277; PMCID: PMC3110545.
    20. Alexander TH, Sage AB, Chen A, Schumacher BL, Shelton E, Masuda K, Sah RL, Watson D. Insulin-like growth factor-I and growth differentiation factor-5 promote the formation of tissue-engineered human nasal septal cartilage. Tissue Eng Part C Methods. 2010 Oct; 16(5):1213-21. PMID: 20178406; PMCID: PMC2943402.
    21. Han EH, Wilensky LM, Schumacher BL, Chen A, Masuda K, Sah RL. Tissue engineering by molecular disassembly and reassembly: biomimetic retention of mechanically functional aggrecan in hydrogel. Tissue Eng Part C Methods. 2010 Dec; 16(6):1471-9. PMID: 20486781; PMCID: PMC2988632.
    22. Williams GM, Dills KJ, Flores CR, Stender ME, Stewart KM, Nelson LM, Chen A, Masuda K, Hazelwood SJ, Klisch SM, Sah RL. Differential regulation of immature articular cartilage compressive moduli and Poisson's ratios by in vitro stimulation with IGF-1 and TGF-beta1. J Biomech. 2010 Sep 17; 43(13):2501-7. PMID: 20570267; PMCID: PMC2937078.
    23. Lane JG, Healey RM, Chen A, Sah RL, Amiel D. Can osteochondral grafting be augmented with microfracture in an extended-size lesion of articular cartilage? Am J Sports Med. 2010 Jul; 38(7):1316-23. PMID: 20400750; PMCID: PMC4111625.
    24. Bae WC, Payanal MM, Chen A, Hsieh-Bonassera ND, Ballard BL, Lotz MK, Coutts RD, Bugbee WD, Sah RL. Topographic Patterns of Cartilage Lesions in Knee Osteoarthritis. Cartilage. 2010 Jan; 1(1):10-19. PMID: 20664706.
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    25. Hsieh-Bonassera ND, Wu I, Lin JK, Schumacher BL, Chen A, Masuda K, Bugbee WD, Sah RL. Expansion and redifferentiation of chondrocytes from osteoarthritic cartilage: cells for human cartilage tissue engineering. Tissue Eng Part A. 2009 Nov; 15(11):3513-23. PMID: 19456239; PMCID: PMC2792054.
    26. Pallante AL, Bae WC, Chen A, Görtz S, Bugbee WD, Sah RL. Chondrocyte viability is higher after prolonged storage at 37 degrees C than at 4 degrees C for osteochondral grafts. Am J Sports Med. 2009 Nov; 37 Suppl 1:24S-32S. PMID: 19861697; PMCID: PMC2858049.
    27. Ficklin T, Thomas G, Barthel JC, Asanbaeva A, Thonar EJ, Masuda K, Chen A, Sah RL, Davol A, Klisch SM. Articular cartilage mechanical and biochemical property relations before and after in vitro growth. J Biomech. 2007; 40(16):3607-14. PMID: 17628568; PMCID: PMC2175072.
    28. Chawla K, Klein TJ, Schumacher BL, Jadin KD, Shah BH, Nakagawa K, Wong VW, Chen A, Masuda K, Sah RL. Short-term retention of labeled chondrocyte subpopulations in stratified tissue-engineered cartilaginous constructs implanted in vivo in mini-pigs. Tissue Eng. 2007 Jul; 13(7):1525-37. PMID: 17532744.
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    29. Richmon JD, Sage A, Wong WV, Chen A, Sah RL, Watson D, Watston D. Compressive biomechanical properties of human nasal septal cartilage. Am J Rhinol. 2006 Sep-Oct; 20(5):496-501. PMID: 17063745.
      View in: PubMed
    30. Borazjani BH, Chen A, Bae WC, Patil S, Sah RL, Firestein GS, Bugbee WD. Effect of impact on chondrocyte viability during insertion of human osteochondral grafts. J Bone Joint Surg Am. 2006 Sep; 88(9):1934-43. PMID: 16951108.
      View in: PubMed
    31. Richmon JD, Sage AB, Wong VW, Chen A, Pan C, Sah RL, Watson D. Tensile biomechanical properties of human nasal septal cartilage. Am J Rhinol. 2005 Nov-Dec; 19(6):617-22. PMID: 16402652.
      View in: PubMed
    32. Lewis CW, Williamson AK, Chen A, Bae WC, Temple MM, Wong WV, Nugent GE, James SP, Wheeler DL, Sah RL, Kawcak CE. Evaluation of subchondral bone mineral density associated with articular cartilage structure and integrity in healthy equine joints with different functional demands. Am J Vet Res. 2005 Oct; 66(10):1823-9. PMID: 16273917.
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    33. Allen RT, Robertson CM, Pennock AT, Bugbee WD, Harwood FL, Wong VW, Chen A, Sah RL, Amiel D. Analysis of stored osteochondral allografts at the time of surgical implantation. Am J Sports Med. 2005 Oct; 33(10):1479-84. PMID: 16009984.
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    34. Schumacher BL, Schmidt TA, Voegtline MS, Chen A, Sah RL. Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus. J Orthop Res. 2005 May; 23(3):562-8. PMID: 15885476.
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    35. Gratz KR, Wong VW, Chen A, Fortier LA, Nixon AJ, Sah RL. Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage. J Biomech. 2006; 39(1):138-46. PMID: 16271598.
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    36. Nugent GE, Law AW, Wong EG, Temple MM, Bae WC, Chen A, Kawcak CE, Sah RL. Site- and exercise-related variation in structure and function of cartilage from equine distal metacarpal condyle. Osteoarthritis Cartilage. 2004 Oct; 12(10):826-33. PMID: 15450533.
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    37. Lane JG, Massie JB, Ball ST, Amiel ME, Chen A, Bae WC, Sah RL, Amiel D. Follow-up of osteochondral plug transfers in a goat model: a 6-month study. Am J Sports Med. 2004 Sep; 32(6):1440-50. PMID: 15310569.
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    38. Ball ST, Amiel D, Williams SK, Tontz W, Chen A, Sah RL, Bugbee WD. The effects of storage on fresh human osteochondral allografts. Clin Orthop Relat Res. 2004 Jan; (418):246-52. PMID: 15043126.
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    39. Chen A, Klisch SM, Bae WC, Temple MM, McGowan KB, Gratz KR, Schumacher BL, Sah RL. Mechanical characterization of native and tissue-engineered cartilage. Methods Mol Med. 2004; 101:157-90. PMID: 15299215.
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    40. Williams SK, Amiel D, Ball ST, Allen RT, Wong VW, Chen A, Sah RL, Bugbee WD. Prolonged storage effects on the articular cartilage of fresh human osteochondral allografts. J Bone Joint Surg Am. 2003 Nov; 85-A(11):2111-20. PMID: 14630839.
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    41. Williamson AK, Chen A, Masuda K, Thonar EJ, Sah RL. Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res. 2003 Sep; 21(5):872-80. PMID: 12919876.
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    42. Giurea A, Klein TJ, Chen A, Goomer RS, Coutts RD, Akeson WH, Amiel D, Sah RL. Adhesion of perichondrial cells to a polylactic acid scaffold. J Orthop Res. 2003 Jul; 21(4):584-9. PMID: 12798055.
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    43. Chen A, Temple MM, Ng DM, Verzijl N, DeGroot J, TeKoppele JM, Sah RL. Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage. Arthritis Rheum. 2002 Dec; 46(12):3212-7. PMID: 12483725.
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    44. Davisson T, Kunig S, Chen A, Sah R, Ratcliffe A. Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage. J Orthop Res. 2002 Jul; 20(4):842-8. PMID: 12168676.
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