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    Sheng Li

    TitleAssociate Researcher
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0652
    CA La Jolla 92093
    Phone858-822-0180
    vCardDownload vCard

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem. 2016 Oct 15; 24(20):4801-4811. PMID: 27320659.
        View in: PubMed
      2. Barkho S, Pierce LC, Li S, Adams JA, Jennings PA. Theoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation. PLoS One. 2015; 10(6):e0127724. PMID: 26030592; PMCID: PMC4452171.
      3. Li S, Lee SY, Chung KY. Conformational analysis of g protein-coupled receptor signaling by hydrogen/deuterium exchange mass spectrometry. Methods Enzymol. 2015; 557:261-78. PMID: 25950969.
        View in: PubMed
      4. Vu LT, Keschrumrus V, Zhang X, Zhong JF, Su Q, Kabeer MH, Loudon WG, Li S. Tissue elasticity regulated tumor gene expression: implication for diagnostic biomarkers of primitive neuroectodermal tumor. PLoS One. 2015; 10(3):e0120336. PMID: 25774514; PMCID: PMC4361745.
      5. Li S, Tachiki LM, Kabeer MH, Dethlefs BA, Anthony MJ, Loudon WG. Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor. Cancer Cell Int. 2014; 14(1):115. PMID: 25411563; PMCID: PMC4236490.
      6. Roberts VA, Pique ME, Ten Eyck LF, Li S. Predicting protein-DNA interactions by full search computational docking. Proteins. 2013 Dec; 81(12):2106-18. PMID: 23966176; PMCID: PMC4045845.
      7. Barkho S, Pierce LC, McGlone ML, Li S, Woods VL, Walker RC, Adams JA, Jennings PA. Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk). PLoS Comput Biol. 2013; 9(9):e1003188. PMID: 24039559; PMCID: PMC3764022.
      8. Marsh JJ, Guan HS, Li S, Chiles PG, Tran D, Morris TA. Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry. Biochemistry. 2013 Aug 13; 52(32):5491-502. PMID: 23875785; PMCID: PMC3821761.
      9. Hsu YH, Bucher D, Cao J, Li S, Yang SW, Kokotos G, Woods VL, McCammon JA, Dennis EA. Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics. J Am Chem Soc. 2013 Jan 30; 135(4):1330-7. PMID: 23256506; PMCID: PMC3561773.
      10. Cao J, Hsu YH, Li S, Woods VL, Dennis EA. Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry. J Lipid Res. 2013 Jan; 54(1):127-33. PMID: 23089916; PMCID: PMC3520519.
      11. Roberts VA, Pique ME, Hsu S, Li S, Slupphaug G, Rambo RP, Jamison JW, Liu T, Lee JH, Tainer JA, Ten Eyck LF, Woods VL. Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Res. 2012 Jul; 40(13):6070-81. PMID: 22492624; PMCID: PMC3401472.
      12. Lu WD, Liu T, Li S, Woods VL, Hook V. The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry. Protein Sci. 2012 Feb; 21(2):178-87. PMID: 22102294; PMCID: PMC3324762.
      13. Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor SS. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol. 2012 Jan 27; 415(4):666-79. PMID: 22138346; PMCID: PMC3445030.
      14. Liu T, Pantazatos D, Li S, Hamuro Y, Hilser VJ, Woods VL. Quantitative assessment of protein structural models by comparison of H/D exchange MS data with exchange behavior accurately predicted by DXCOREX. J Am Soc Mass Spectrom. 2012 Jan; 23(1):43-56. PMID: 22012689; PMCID: PMC3889642.
      15. Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL, Stout CD, Hollenberg PF, Halpert JR. Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. Biochemistry. 2011 Jun 07; 50(22):4903-11. PMID: 21510666; PMCID: PMC3105221.
      16. Plocinik RM, Li S, Liu T, Hailey KL, Whitesides J, Whitehouse J, Ma CT, Fu XD, Gosh G, Woods VL, Jennings PA, Adams JA. Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1. J Mol Biol. 2011 Jul 01; 410(1):131-45. PMID: 21600902; PMCID: PMC3121894.
      17. Lee JH, Li S, Liu T, Hsu S, Kim C, Woods VL, Casteel DE. The amino terminus of cGMP-dependent protein kinase Iß increases the dynamics of the protein's cGMP-binding pockets. Int J Mass Spectrom. 2011 Apr 30; 302(1-3):44-52. PMID: 21643460.
        View in: PubMed
      18. Li S, Tsalkova T, White MA, Mei FC, Liu T, Wang D, Woods VL, Cheng X. Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Biol Chem. 2011 May 20; 286(20):17889-97. PMID: 21454623; PMCID: PMC3093864.
      19. Wilderman PR, Shah MB, Liu T, Li S, Hsu S, Roberts AG, Goodlett DR, Zhang Q, Woods VL, Stout CD, Halpert JR. Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography. J Biol Chem. 2010 Dec 03; 285(49):38602-11. PMID: 20880847; PMCID: PMC2992292.
      20. Li S, Tachiki LM, Luo J, Dethlefs BA, Chen Z, Loudon WG. A biological global positioning system: considerations for tracking stem cell behaviors in the whole body. Stem Cell Rev. 2010 Jun; 6(2):317-33. PMID: 20237964; PMCID: PMC2887536.
      21. Mendillo ML, Putnam CD, Mo AO, Jamison JW, Li S, Woods VL, Kolodner RD. Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry. J Biol Chem. 2010 Apr 23; 285(17):13170-82. PMID: 20181951; PMCID: PMC2857143.
      22. Mendillo ML, Hargreaves VV, Jamison JW, Mo AO, Li S, Putnam CD, Woods VL, Kolodner RD. A conserved MutS homolog connector domain interface interacts with MutL homologs. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22223-8. PMID: 20080788; PMCID: PMC2796910.
      23. Steichen JM, Iyer GH, Li S, Saldanha SA, Deal MS, Woods VL, Taylor SS. Global consequences of activation loop phosphorylation on protein kinase A. J Biol Chem. 2010 Feb 05; 285(6):3825-32. PMID: 19965870; PMCID: PMC2823524.
      24. Hsu S, Kim Y, Li S, Durrant ES, Pace RM, Woods VL, Gentry MS. Structural insights into glucan phosphatase dynamics using amide hydrogen-deuterium exchange mass spectrometry. Biochemistry. 2009 Oct 20; 48(41):9891-902. PMID: 19754155; PMCID: PMC2767375.
      25. Hsu YH, Burke JE, Li S, Woods VL, Dennis EA. Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2009 Aug 28; 284(35):23652-61. PMID: 19556238; PMCID: PMC2749140.
      26. Burke JE, Babakhani A, Gorfe AA, Kokotos G, Li S, Woods VL, McCammon JA, Dennis EA. Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry. J Am Chem Soc. 2009 Jun 17; 131(23):8083-91. PMID: 19459633; PMCID: PMC2762749.
      27. Lu WD, Asmus K, Hwang SR, Li S, Woods VL, Hook V. Differential accessibilities of dibasic prohormone processing sites of proenkephalin to the aqueous environment revealed by H-D exchange mass spectrometry. Biochemistry. 2009 Feb 24; 48(7):1604-12. PMID: 19173595; PMCID: PMC2752437.
      28. Burke JE, Karbarz MJ, Deems RA, Li S, Woods VL, Dennis EA. Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry. Biochemistry. 2008 Jun 17; 47(24):6451-9. PMID: 18500818; PMCID: PMC2459553.
      29. Hsu YH, Burke JE, Stephens DL, Deems RA, Li S, Asmus KM, Woods VL, Dennis EA. Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2008 Apr 11; 283(15):9820-7. PMID: 18211893; PMCID: PMC2442293.
      30. Jin L, Milazzo AC, Kleinfelder S, Li S, Leblanc P, Duttweiler F, Bouwer JC, Peltier ST, Ellisman MH, Xuong NH. Applications of direct detection device in transmission electron microscopy. J Struct Biol. 2008 Mar; 161(3):352-8. PMID: 18054249; PMCID: PMC2359769.
      31. Golynskiy M, Li S, Woods VL, Cohen SM. Conformational studies of the manganese transport regulator (MntR) from Bacillus subtilis using deuterium exchange mass spectrometry. J Biol Inorg Chem. 2007 Jun; 12(5):699-709. PMID: 17342524.
        View in: PubMed
      32. Xuong NH, Jin L, Kleinfelder S, Li S, Leblanc P, Duttweiler F, Bouwer JC, Peltier ST, Milazzo AC, Ellisman M. Future directions for camera systems in electron microscopy. Methods Cell Biol. 2007; 79:721-39. PMID: 17327181.
        View in: PubMed