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Sheng Li

Title(s)Researcher, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0652
La Jolla CA 92093
Phone8/8-22--0180
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. J Biol Chem. 2020 Jul 24; 295(30):10394-10405. Chan MH, Aminzai S, Hu T, Taran A, Li S, Kim C, Pilz RB, Casteel DE. PMID: 32506052.
      View in: PubMed   Mentions:    Fields:    
    2. Efficient Golgi Forward Trafficking Requires GOLPH3-Driven, PI4P-Dependent Membrane Curvature. Dev Cell. 2019 09 09; 50(5):573-585.e5. Rahajeng J, Kuna RS, Makowski SL, Tran TTT, Buschman MD, Li S, Cheng N, Ng MM, Field SJ. PMID: 31231041.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    3. Combining H/D Exchange Mass Spectrometry and Computational Docking To Derive the Structure of Protein-Protein Complexes. Biochemistry. 2017 Dec 05; 56(48):6329-6342. Roberts VA, Pique ME, Hsu S, Li S. PMID: 29099587.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    4. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem. 2016 10 15; 24(20):4801-4811. Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. PMID: 27320659.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    5. Theoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation. PLoS One. 2015; 10(6):e0127724. Barkho S, Pierce LC, Li S, Adams JA, Jennings PA. PMID: 26030592.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. Conformational analysis of g protein-coupled receptor signaling by hydrogen/deuterium exchange mass spectrometry. Methods Enzymol. 2015; 557:261-78. Li S, Lee SY, Chung KY. PMID: 25950969.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Predicting protein-DNA interactions by full search computational docking. Proteins. 2013 Dec; 81(12):2106-18. Roberts VA, Pique ME, Ten Eyck LF, Li S. PMID: 23966176.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk). PLoS Comput Biol. 2013; 9(9):e1003188. Barkho S, Pierce LC, McGlone ML, Li S, Woods VL, Walker RC, Adams JA, Jennings PA. PMID: 24039559.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    9. Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry. Biochemistry. 2013 Aug 13; 52(32):5491-502. Marsh JJ, Guan HS, Li S, Chiles PG, Tran D, Morris TA. PMID: 23875785.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    10. Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics. J Am Chem Soc. 2013 Jan 30; 135(4):1330-7. Hsu YH, Bucher D, Cao J, Li S, Yang SW, Kokotos G, Woods VL, McCammon JA, Dennis EA. PMID: 23256506.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    11. Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry. J Lipid Res. 2013 Jan; 54(1):127-33. Cao J, Hsu YH, Li S, Woods VL, Dennis EA. PMID: 23089916.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Res. 2012 Jul; 40(13):6070-81. Roberts VA, Pique ME, Hsu S, Li S, Slupphaug G, Rambo RP, Jamison JW, Liu T, Lee JH, Tainer JA, Ten Eyck LF, Woods VL. PMID: 22492624.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    13. The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry. Protein Sci. 2012 Feb; 21(2):178-87. Lu WD, Liu T, Li S, Woods VL, Hook V. PMID: 22102294.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol. 2012 Jan 27; 415(4):666-79. Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor SS. PMID: 22138346.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    15. Quantitative assessment of protein structural models by comparison of H/D exchange MS data with exchange behavior accurately predicted by DXCOREX. J Am Soc Mass Spectrom. 2012 Jan; 23(1):43-56. Liu T, Pantazatos D, Li S, Hamuro Y, Hilser VJ, Woods VL. PMID: 22012689.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    16. Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. Biochemistry. 2011 Jun 07; 50(22):4903-11. Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL, Stout CD, Hollenberg PF, Halpert JR. PMID: 21510666.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    17. Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1. J Mol Biol. 2011 Jul 01; 410(1):131-45. Plocinik RM, Li S, Liu T, Hailey KL, Whitesides J, Whitehouse J, Ma CT, Fu XD, Gosh G, Woods VL, Jennings PA, Adams JA. PMID: 21600902.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. The amino terminus of cGMP-dependent protein kinase Iß increases the dynamics of the protein's cGMP-binding pockets. Int J Mass Spectrom. 2011 Apr 30; 302(1-3):44-52. Lee JH, Li S, Liu T, Hsu S, Kim C, Woods VL, Casteel DE. PMID: 21643460.
      View in: PubMed   Mentions:
    19. Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Biol Chem. 2011 May 20; 286(20):17889-97. Li S, Tsalkova T, White MA, Mei FC, Liu T, Wang D, Woods VL, Cheng X. PMID: 21454623.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    20. Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography. J Biol Chem. 2010 Dec 03; 285(49):38602-11. Wilderman PR, Shah MB, Liu T, Li S, Hsu S, Roberts AG, Goodlett DR, Zhang Q, Woods VL, Stout CD, Halpert JR. PMID: 20880847.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    21. Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry. J Biol Chem. 2010 Apr 23; 285(17):13170-82. Mendillo ML, Putnam CD, Mo AO, Jamison JW, Li S, Woods VL, Kolodner RD. PMID: 20181951.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    22. A conserved MutS homolog connector domain interface interacts with MutL homologs. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22223-8. Mendillo ML, Hargreaves VV, Jamison JW, Mo AO, Li S, Putnam CD, Woods VL, Kolodner RD. PMID: 20080788.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    23. Global consequences of activation loop phosphorylation on protein kinase A. J Biol Chem. 2010 Feb 05; 285(6):3825-32. Steichen JM, Iyer GH, Li S, Saldanha SA, Deal MS, Woods VL, Taylor SS. PMID: 19965870.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    24. Structural insights into glucan phosphatase dynamics using amide hydrogen-deuterium exchange mass spectrometry. Biochemistry. 2009 Oct 20; 48(41):9891-902. Hsu S, Kim Y, Li S, Durrant ES, Pace RM, Woods VL, Gentry MS. PMID: 19754155.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    25. Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2009 Aug 28; 284(35):23652-61. Hsu YH, Burke JE, Li S, Woods VL, Dennis EA. PMID: 19556238.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    26. Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry. J Am Chem Soc. 2009 Jun 17; 131(23):8083-91. Burke JE, Babakhani A, Gorfe AA, Kokotos G, Li S, Woods VL, McCammon JA, Dennis EA. PMID: 19459633.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    27. Differential accessibilities of dibasic prohormone processing sites of proenkephalin to the aqueous environment revealed by H-D exchange mass spectrometry. Biochemistry. 2009 Feb 24; 48(7):1604-12. Lu WD, Asmus K, Hwang SR, Li S, Woods VL, Hook V. PMID: 19173595.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    28. Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry. Biochemistry. 2008 Jun 17; 47(24):6451-9. Burke JE, Karbarz MJ, Deems RA, Li S, Woods VL, Dennis EA. PMID: 18500818.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    29. Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2008 Apr 11; 283(15):9820-7. Hsu YH, Burke JE, Stephens DL, Deems RA, Li S, Asmus KM, Woods VL, Dennis EA. PMID: 18211893.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    30. Applications of direct detection device in transmission electron microscopy. J Struct Biol. 2008 Mar; 161(3):352-8. Jin L, Milazzo AC, Kleinfelder S, Li S, Leblanc P, Duttweiler F, Bouwer JC, Peltier ST, Ellisman MH, Xuong NH. PMID: 18054249.
      View in: PubMed   Mentions: 23     Fields:    
    31. Conformational studies of the manganese transport regulator (MntR) from Bacillus subtilis using deuterium exchange mass spectrometry. J Biol Inorg Chem. 2007 Jun; 12(5):699-709. Golynskiy M, Li S, Woods VL, Cohen SM. PMID: 17342524.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    32. Future directions for camera systems in electron microscopy. Methods Cell Biol. 2007; 79:721-39. Xuong NH, Jin L, Kleinfelder S, Li S, Leblanc P, Duttweiler F, Bouwer JC, Peltier ST, Milazzo AC, Ellisman M. PMID: 17327181.
      View in: PubMed   Mentions: 4     Fields:    
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