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Andrew Mizisin

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0719
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Oxidative Stress and Nerve Pathology in Diabetes
    NIH/NIDDK R01DK078373Sep 15, 2006 - Aug 31, 2010
    Role: Principal Investigator
    POLYOL PATHWAY AND NEUROTROPHIC FACTORS IN DIABETES
    NIH/NINDS R01NS032339Aug 1, 1994 - Jul 31, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mizisin A. Mechanisms of diabetic neuropathy: Schwann cells. Handb Clin Neurol. 2014; 126:401-28. PMID: 25410236.
      View in: PubMed
    2. Chen DK, Frizzi KE, Guernsey LS, Ladt K, Mizisin A, Calcutt NA. Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin. J Peripher Nerv Syst. 2013 Dec; 18(4):306-15. PMID: 24147903; PMCID: PMC3981941.
    3. Bagel JH, Sikora TU, Prociuk M, Pesayco JP, Mizisin A, Shelton GD, Vite CH. Electrodiagnostic testing and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease type C. J Neuropathol Exp Neurol. 2013 Mar; 72(3):256-62. PMID: 23399903; PMCID: PMC3640270.
    4. Gregory JA, Jolivalt CG, Goor J, Mizisin A, Calcutt NA. Hypertension-induced peripheral neuropathy and the combined effects of hypertension and diabetes on nerve structure and function in rats. Acta Neuropathol. 2012 Oct; 124(4):561-73. PMID: 22791295.
      View in: PubMed
    5. Shelton GD, Johnson GC, O'Brien DP, Katz ML, Pesayco JP, Chang BJ, Mizisin A, Coates JR. Degenerative myelopathy associated with a missense mutation in the superoxide dismutase 1 (SOD1) gene progresses to peripheral neuropathy in Pembroke Welsh corgis and boxers. J Neurol Sci. 2012 Jul 15; 318(1-2):55-64. PMID: 22542607.
      View in: PubMed
    6. Kim Y, Remacle AG, Chernov AV, Liu H, Shubayev I, Lai C, Dolkas J, Shiryaev SA, Golubkov VS, Mizisin A, Strongin AY, Shubayev VI. The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration. PLoS One. 2012; 7(3):e33664. PMID: 22438979; PMCID: PMC3306282.
    7. Weerasuriya A, Mizisin A. The blood-nerve barrier: structure and functional significance. Methods Mol Biol. 2011; 686:149-73. PMID: 21082370.
      View in: PubMed
    8. Mizisin A, Weerasuriya A. Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult. Acta Neuropathol. 2011 Mar; 121(3):291-312. PMID: 21136068; PMCID: PMC3038236.
    9. Beggs AH, Böhm J, Snead E, Kozlowski M, Maurer M, Minor K, Childers MK, Taylor SM, Hitte C, Mickelson JR, Guo LT, Mizisin A, Buj-Bello A, Tiret L, Laporte J, Shelton GD. MTM1 mutation associated with X-linked myotubular myopathy in Labrador Retrievers. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14697-702. PMID: 20682747; PMCID: PMC2930454.
    10. Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin A, Shelton GD, Lieber RL, Chen J. Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15; 19(2):329-41. PMID: 19864491; PMCID: PMC2796894.
    11. Calcutt NA, Lopez VL, Bautista AD, Mizisin LM, Torres BR, Shroads AL, Mizisin A, Stacpoole PW. Peripheral neuropathy in rats exposed to dichloroacetate. J Neuropathol Exp Neurol. 2009 Sep; 68(9):985-93. PMID: 19680144; PMCID: PMC2741559.
    12. King J, LeCouteur RA, Aleman M, Williams DC, Moore PF, Guo LT, Mizisin A, Shelton GD. Vacuolar myopathy in a dog resembling human sporadic inclusion body myositis. Acta Neuropathol. 2009 Nov; 118(5):711-7. PMID: 19718499.
      View in: PubMed
    13. Page LJ, Suk JY, Bazhenova L, Fleming SM, Wood M, Jiang Y, Guo LT, Mizisin A, Kisilevsky R, Shelton GD, Balch WE, Kelly JW. Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11125-30. PMID: 19549824; PMCID: PMC2708763.
    14. Chen Q, Peto CA, Shelton GD, Mizisin A, Sawchenko PE, Schubert D. Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration. J Neurosci. 2009 Jan 07; 29(1):118-30. PMID: 19129390; PMCID: PMC2669744.
    15. Vanhaesebrouck AE, Couturier J, Cauzinille L, Mizisin A, Shelton GD, Granger N. Demyelinating polyneuropathy with focally folded myelin sheaths in a family of Miniature Schnauzer dogs. J Neurol Sci. 2008 Dec 15; 275(1-2):100-5. PMID: 18809183.
      View in: PubMed
    16. Beiswenger KK, Calcutt NA, Mizisin A. Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice. Neurosci Lett. 2008 Sep 19; 442(3):267-72. PMID: 18619518; PMCID: PMC2610845.
    17. Jolivalt CG, Vu Y, Mizisin LM, Mizisin A, Calcutt NA. Impaired prosaposin secretion during nerve regeneration in diabetic rats and protection of nerve regeneration by a prosaposin-derived peptide. J Neuropathol Exp Neurol. 2008 Jul; 67(7):702-10. PMID: 18596543; PMCID: PMC2748883.
    18. Cunha JM, Jolivalt CG, Ramos KM, Gregory JA, Calcutt NA, Mizisin A. Elevated lipid peroxidation and DNA oxidation in nerve from diabetic rats: effects of aldose reductase inhibition, insulin, and neurotrophic factors. Metabolism. 2008 Jul; 57(7):873-81. PMID: 18555826; PMCID: PMC2518323.
    19. Beiswenger KK, Calcutt NA, Mizisin A. Epidermal nerve fiber quantification in the assessment of diabetic neuropathy. Acta Histochem. 2008; 110(5):351-62. PMID: 18384843; PMCID: PMC2561960.
    20. Delaunay A, Bromberg KD, Hayashi Y, Mirabella M, Burch D, Kirkwood B, Serra C, Malicdan MC, Mizisin A, Morosetti R, Broccolini A, Guo LT, Jones SN, Lira SA, Puri PL, Shelton GD, Ronai Z. The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis. PLoS One. 2008 Feb 13; 3(2):e1609. PMID: 18270596; PMCID: PMC2229664.
    21. Estrella JS, Nelson RN, Sturges BK, Vernau KM, Williams DC, LeCouteur RA, Shelton GD, Mizisin A. Endoneurial microvascular pathology in feline diabetic neuropathy. Microvasc Res. 2008 Apr; 75(3):403-10. PMID: 18207200; PMCID: PMC2413429.
    22. Li ZF, Wu X, Jiang Y, Liu J, Wu C, Inagaki M, Izawa I, Mizisin A, Engvall E, Shelton GD. Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice. J Neurol Sci. 2008 Jan 15; 264(1-2):77-86. PMID: 17854834.
      View in: PubMed
    23. Shelton GD, Sturges BK, Lyons LA, Williams DC, Aleman M, Jiang Y, Mizisin A. Myopathy with tubulin-reactive inclusions in two cats. Acta Neuropathol. 2007 Nov; 114(5):537-42. PMID: 17393175.
      View in: PubMed
    24. Mizisin A, Nelson RW, Sturges BK, Vernau KM, Lecouteur RA, Williams DC, Burgers ML, Shelton GD. Comparable myelinated nerve pathology in feline and human diabetes mellitus. Acta Neuropathol. 2007 Apr; 113(4):431-42. PMID: 17237938.
      View in: PubMed
    25. Jiang Y, Calcutt NA, Ramos KM, Rames KM, Mizisin A. Novel sites of aldose reductase immunolocalization in normal and streptozotocin-diabetic rats. J Peripher Nerv Syst. 2006 Dec; 11(4):274-85. PMID: 17117935.
      View in: PubMed
    26. Jacobson ER, Homer BL, Stacy BA, Greiner EC, Szabo NJ, Chrisman CL, Origgi F, Coberley S, Foley AM, Landsberg JH, Flewelling L, Ewing RY, Moretti R, Schaf S, Rose C, Mader DR, Harman GR, Manire CA, Mettee NS, Mizisin A, Shelton GD. Neurological disease in wild loggerhead sea turtles Caretta caretta. Dis Aquat Organ. 2006 Jun 12; 70(1-2):139-54. PMID: 16875401.
      View in: PubMed
    27. Calcutt NA, Freshwater JD, Hauptmann N, Taylor EM, Mizisin A. Protection of sensory function in diabetic rats by Neotrofin. Eur J Pharmacol. 2006 Mar 18; 534(1-3):187-93. PMID: 16507305.
      View in: PubMed
    28. Kube SA, Vernau KM, LeCouteur RA, Mizisin A, Shelton GD. Congenital myopathy with abundant nemaline rods in a cat. Neuromuscul Disord. 2006 Mar; 16(3):188-91. PMID: 16487709.
      View in: PubMed
    29. Yücel YH, Gupta N, Zhang Q, Mizisin A, Kalichman MW, Weinreb RN. Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma. Arch Ophthalmol. 2006 Feb; 124(2):217-25. PMID: 16476892.
      View in: PubMed
    30. Malmberg AB, Mizisin A, Calcutt NA, von Stein T, Robbins WR, Bley KR. Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch. Pain. 2004 Oct; 111(3):360-7. PMID: 15363880.
      View in: PubMed
    31. Shelton GD, Sammut V, Homma S, Takayama S, Mizisin A. Myofibrillar myopathy with desmin accumulation in a young Australian Shepherd dog. Neuromuscul Disord. 2004 Jul; 14(7):399-404. PMID: 15210162.
      View in: PubMed
    32. Mizisin A, Vu Y, Shuff M, Calcutt NA. Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats. Diabetes. 2004 Jul; 53(7):1807-12. PMID: 15220205.
      View in: PubMed
    33. Mizisin A. Comparative neuropathology and diabetic autonomic neuropathy. Am J Pathol. 2003 Nov; 163(5):1703-6. PMID: 14578168; PMCID: PMC1892438.
    34. Sayers NM, Beswick LJ, Middlemas A, Calcutt NA, Mizisin A, Tomlinson DR, Fernyhough P. Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats. Diabetes. 2003 Sep; 52(9):2372-80. PMID: 12941778.
      View in: PubMed
    35. Jolivalt CG, Howard RB, Chen LS, Mizisin A, Lai CS. A novel nitric oxide scavenger in combination with cyclosporine A ameliorates experimental autoimmune encephalomyelitis progression in mice. J Neuroimmunol. 2003 May; 138(1-2):56-64. PMID: 12742654.
      View in: PubMed
    36. Shelton GD, Podell M, Poncelet L, Schatzberg S, Patterson E, Powell HC, Mizisin A. Inherited polyneuropathy in Leonberger dogs: a mixed or intermediate form of Charcot-Marie-Tooth disease? Muscle Nerve. 2003 Apr; 27(4):471-7. PMID: 12661049.
      View in: PubMed
    37. Calcutt NA, Allendoerfer KL, Mizisin A, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DR. Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J Clin Invest. 2003 Feb; 111(4):507-14. PMID: 12588889; PMCID: PMC151919.
    38. Mizisin A, Shelton GD, Burgers ML, Powell HC, Cuddon PA. Neurological complications associated with spontaneously occurring feline diabetes mellitus. J Neuropathol Exp Neurol. 2002 Oct; 61(10):872-84. PMID: 12387453.
      View in: PubMed
    39. Mizisin A, DiStefano PS, Liu X, Garrett DN, Tonra JR. Decreased accumulation of endogenous brain-derived neurotrophic factor against constricting sciatic nerve ligatures in streptozotocin-diabetic and galactose-fed rats. Neurosci Lett. 1999 Mar 26; 263(2-3):149-52. PMID: 10213157.
      View in: PubMed
    40. Mizisin A, Calcutt NA, Tomlinson DR, Gallagher A, Fernyhough P. Neurotrophin-3 reverses nerve conduction velocity deficits in streptozotocin-diabetic rats. J Peripher Nerv Syst. 1999; 4(3-4):211-21. PMID: 10642089.
      View in: PubMed
    41. Mizisin A, Kalichman MW, Garrett RS, Dines KC. Tactile hyperesthesia, altered epidermal innervation and plantar nerve injury in the hindfeet of rats housed on wire grates. Brain Res. 1998 Mar 30; 788(1-2):13-9. PMID: 9554936.
      View in: PubMed
    42. Mizisin A, Shelton GD, Wagner S, Rusbridge C, Powell HC. Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy. Acta Neuropathol. 1998 Feb; 95(2):171-4. PMID: 9498053.
      View in: PubMed
    43. Mizisin A, Li L, Calcutt NA. Sorbitol accumulation and transmembrane efflux in osmotically stressed JS1 schwannoma cells. Neurosci Lett. 1997 Jun 20; 229(1):53-6. PMID: 9224800.
      View in: PubMed
    44. Mizisin A, Powell HC. Schwann cell changes induced as early as one week after galactose intoxication. Acta Neuropathol. 1997 Jun; 93(6):611-8. PMID: 9194901.
      View in: PubMed
    45. Mizisin A, Calcutt NA, DiStefano PS, Acheson A, Longo FM. Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats. Diabetes. 1997 Apr; 46(4):647-52. PMID: 9075806.
      View in: PubMed