Kirk Knowlton

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9300 Campus Point Drive #7411
La Jolla CA 92037
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    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Aug 13, 2009 - Mar 31, 2014
    Role: Co-Investigator
    Role of mTOR, a Component of the Akt Pathway, in Regulating Cardiac Function
    NIH/NHLBI R01HL078797Dec 1, 2004 - Nov 30, 2014
    Role: Principal Investigator
    Dystrophin-glycoprotein complex in viral cardiomyopathy
    NIH/NHLBI R01HL066424Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    Cardiac SOCS Proteins: A Role in Enterovirus Infection
    NIH/NHLBI R01HL057365Dec 5, 1998 - Nov 30, 2002
    Role: Principal Investigator
    NIH/NHLBI P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Co-Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH/NHLBI P01HL046345Feb 1, 1992 - Sep 30, 1997
    Role: Principal Investigator
    NIH/NHLBI K08HL002618Aug 1, 1991 - Jul 31, 1997
    Role: Principal Investigator
    Training in Cardiovascular Physiology and Pharmacology
    NIH/NHLBI T32HL007444Jul 1, 1979 - Sep 29, 1990
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pathogenesis of SARS-CoV-2 induced cardiac injury from the perspective of the virus. J Mol Cell Cardiol. 2020 Aug 06; 147:12-17. Knowlton KU. PMID: 32771409.
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    2. How Community-Based Health Systems Embrace Research During the COVID-19 Pandemic. Qual Manag Health Care. 2020 Jul/Sep; 29(3):173-175. Brunisholz KD, Knighton AJ, Webb B, Brown SM, Peltan ID, Stenehjem E, Knowlton K, Belnap TW, Quam J, Srivastava R. PMID: 32590494.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    3. Intermountain chronic disease risk score (ICHRON) validation for prediction of incident chronic disease diagnoses in an australian primary prevention population. Eur J Intern Med. 2020 Sep; 79:81-87. May HT, Anderson JL, Muhlestein JB, Knowlton KU, Horne BD. PMID: 32563688.
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    4. Predictors of Statin Intolerance in Patients With a New Diagnosis of Atherosclerotic Cardiovascular Disease Within a Large Integrated Health Care Institution: The IMPRES Study. J Cardiovasc Pharmacol. 2020 May; 75(5):426-431. Bair TL, May HT, Knowlton KU, Anderson JL, Lappe DL, Muhlestein JB. PMID: 32079856.
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    5. Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function. Circ Res. 2020 Jul 03; 127(2):284-297. Zhang J, Vincent KP, Peter AK, Klos M, Cheng H, Huang SM, Towne JK, Ferng D, Gu Y, Dalton ND, Chan Y, Li R, Peterson KL, Chen J, McCulloch AD, Knowlton KU, Ross RS. PMID: 32345129.
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    6. Absence of Coronary Artery Calcium During Positron Emission Tomography Stress Testing in Patients Without Known Coronary Artery Disease Identifies Individuals With Very Low Risk of Cardiac Events. Circ Cardiovasc Imaging. 2020 01; 13(1):e009907. Le VT, Knight S, Min DB, McCubrey RO, Horne BD, Jensen KR, Meredith KG, Mason SM, Lappé DL, Anderson JL, Muhlestein JB, Knowlton KU. PMID: 31959008.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Free thyroxine within the normal reference range predicts risk of atrial fibrillation. J Cardiovasc Electrophysiol. 2020 01; 31(1):18-29. Anderson JL, Jacobs V, May HT, Bair TL, Benowitz BA, Lappe DL, Muhlestein JB, Knowlton KU, Bunch TJ. PMID: 31515856.
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    8. Comparison of Three Atherosclerotic Cardiovascular Disease Risk Scores With and Without Coronary Calcium for Predicting Revascularization and Major Adverse Coronary Events in Symptomatic Patients Undergoing Positron Emission Tomography-Stress Testing. Am J Cardiol. 2020 02 01; 125(3):341-348. Anderson JL, Le VT, Min DB, Biswas S, Minder CM, McCubrey RO, Knight S, Horne BD, Mason S, Lappe DL, Muhlestein JB, Knowlton KU. PMID: 31806210.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Value of Neutrophil to Lymphocyte Ratio and Its Trajectory in Patients Hospitalized With Acute Heart Failure and Preserved Ejection Fraction. Am J Cardiol. 2020 01 15; 125(2):229-235. Boralkar KA, Kobayashi Y, Amsallem M, Ataam JA, Moneghetti KJ, Cauwenberghs N, Horne BD, Knowlton KU, Maecker H, Kuznetsova T, Heidenreich PA, Haddad F. PMID: 31753313.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Circulating Levels of Biomarkers of Cerebral Injury in Patients with Atrial Fibrillation. Am J Cardiol. 2019 12 01; 124(11):1697-1700. Galenko O, Jacobs V, Knight S, Bride D, Cutler MJ, Muhlestein JB, Carlquist JL, Anderson JL, Knowlton KU, Jared Bunch T. PMID: 31575426.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Approaching Higher Dimension Imaging Data Using Cluster-Based Hierarchical Modeling in Patients with Heart Failure Preserved Ejection Fraction. Sci Rep. 2019 07 18; 9(1):10431. Kobayashi Y, Tremblay-Gravel M, Boralkar KA, Li X, Nishi T, Amsallem M, Moneghetti KJ, Bouajila S, Selej M, Ozen MO, Demirci U, Ashley E, Wheeler M, Knowlton KU, Kouznetsova T, Haddad F. PMID: 31320698.
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    12. Improving risk stratification in heart failure with preserved ejection fraction by combining two validated risk scores. Open Heart. 2019; 6(1):e000961. Boralkar KA, Kobayashi Y, Moneghetti KJ, Pargaonkar VS, Tuzovic M, Krishnan G, Wheeler MT, Banerjee D, Kuznetsova T, Horne BD, Knowlton KU, Heidenreich PA, Haddad F. PMID: 31217994.
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    13. Dilated Cardiomyopathy. Circulation. 2019 05 14; 139(20):2339-2341. Knowlton KU. PMID: 31082299.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture. Circulation. 2019 03 19; 139(12):1554-1556. Zhang Z, Mu Y, Zhang J, Zhou Y, Cattaneo P, Veevers J, Peter AK, Manso AM, Knowlton KU, Zhou X, Evans SM, Ross RS, Chen J. PMID: 30883226.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Safety and Efficacy of Periprocedural Heparin Plus a Short-Term Infusion of Tirofiban Versus Bivalirudin Monotherapy in Patients Who Underwent Percutaneous Coronary Intervention (from the Intermountain Heart Institute STAIR Observational Registry). Am J Cardiol. 2019 06 15; 123(12):1927-1934. Muhlestein JB, Hackett IS, May HT, Bair TL, Le VT, Anderson JL, Whisenant B, Knowlton KU, Lappé DL. PMID: 30981419.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. The role of microRNAs in the development, regulation, and treatment of atrial fibrillation. J Interv Card Electrophysiol. 2019 Sep; 55(3):297-305. Galenko O, Jacobs V, Knight S, Taylor M, Cutler MJ, Muhlestein JB, Carlquist JL, Knowlton KU, Jared Bunch T. PMID: 30607665.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. CHA2DS2-VASc scores and Intermountain Mortality Risk Scores for the joint risk stratification of dementia among patients with atrial fibrillation. Heart Rhythm. 2019 01; 16(1):3-9. Graves KG, May HT, Jacobs V, Knowlton KU, Muhlestein JB, Lappe DL, Anderson JL, Horne BD, Bunch TJ. PMID: 30611392.
      View in: PubMed   Mentions: 1     Fields:    
    18. Prediction of Long-Term Incidence of Chronic Cardiovascular and Cardiopulmonary Diseases in Primary Care Patients for Population Health Monitoring: The Intermountain Chronic Disease Model (ICHRON). Mayo Clin Proc. 2019 07; 94(7):1221-1230. May HT, Lappé DL, Knowlton KU, Muhlestein JB, Anderson JL, Horne BD. PMID: 30577973.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Improving CHA2DS2-VASc stratification of non-fatal stroke and mortality risk using the Intermountain Mortality Risk Score among patients with atrial fibrillation. Open Heart. 2018; 5(2):e000907. Graves KG, May HT, Knowlton KU, Muhlestein JB, Jacobs V, Lappé DL, Anderson JL, Horne BD, Bunch TJ. PMID: 30564375.
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    20. Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells. Stem Cell Reports. 2018 09 11; 11(3):828-841. Veevers J, Farah EN, Corselli M, Witty AD, Palomares K, Vidal JG, Emre N, Carson CT, Ouyang K, Liu C, van Vliet P, Zhu M, Hegarty JM, Deacon DC, Grinstein JD, Dirschinger RJ, Frazer KA, Adler ED, Knowlton KU, Chi NC, Martin JC, Chen J, Evans SM. PMID: 30122443.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Extreme erythrocyte macrocytic and microcytic percentages are highly predictive of morbidity and mortality. JCI Insight. 2018 07 26; 3(14). Horne BD, Muhlestein JB, Bennett ST, Muhlestein JB, Jensen KR, Marshall D, Bair TL, May HT, Carlquist JF, Hegewald M, Knight S, Le VT, Bunch TJ, Lappé DL, Anderson JL, Knowlton KU. PMID: 30046011.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. How Community-Based Health Systems Can Embrace Research in the Fee-for-Value Era. Qual Manag Health Care. 2018 Jul/Sep; 27(3):180-182. Knighton AJ, Grissom CK, Knowlton KU, Sean Esplin M, Graydon T, Srivastava R. PMID: 29944632.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Implementation of a cardiac PET stress program: comparison of outcomes to the preceding SPECT era. JCI Insight. 2018 05 03; 3(9). Knight S, Min DB, Le VT, Meredith KG, Dhar R, Biswas S, Jensen KR, Mason SM, Ethington JD, Lappe DL, Muhlestein JB, Anderson JL, Knowlton KU. PMID: 29720565.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. GlycA and hsCRP are independent and additive predictors of future cardiovascular events among patients undergoing angiography: The intermountain heart collaborative study. Am Heart J. 2018 08; 202:27-32. Muhlestein JB, May HT, Galenko O, Knowlton KU, Otvos JD, Connelly MA, Lappe DL, Anderson JL. PMID: 29803983.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Temporal changes in statin prescription and intensity at discharge and impact on outcomes in patients with newly diagnosed atherosclerotic cardiovascular disease-Real-world experience within a large integrated health care system: The IMPRES study. J Clin Lipidol. 2018 Jul - Aug; 12(4):1008-1018.e1. Anderson JL, Knowlton KU, May HT, Bair TL, Armstrong SO, Lappé DL, Muhlestein JB. PMID: 29703626.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    26. Real world MRI experience with nonconditional and conditional cardiac rhythm devices after MagnaSafe. J Cardiovasc Electrophysiol. 2017 Dec; 28(12):1468-1474. Mason S, Osborn JS, Dhar R, Tonkin A, Ethington JD, Le V, Benuzillo J, Lappe DL, Knowlton KU, Bunch TJ, Anderson JL. PMID: 28960745.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. The association of depression at any time to the risk of death following coronary artery disease diagnosis. Eur Heart J Qual Care Clin Outcomes. 2017 10 01; 3(4):296-302. May HT, Horne BD, Knight S, Knowlton KU, Bair TL, Lappé DL, Le VT, Muhlestein JB. PMID: 28950317.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Myocarditis: An Intersection Between Genetic and Acquired Causes of Human Cardiomyopathy. J Am Coll Cardiol. 2017 04 04; 69(13):1666-1668. Knowlton KU. PMID: 28359510.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    29. Increased Echogenicity and Radiodense Foci on Echocardiogram and MicroCT in Murine Myocarditis. PLoS One. 2016; 11(8):e0159971. Peter AK, Bradford WH, Dalton ND, Gu Y, Chao CJ, Peterson KL, Knowlton KU. PMID: 27486657.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. Circ Heart Fail. 2016 08; 9(8). Zhang Z, Mu Y, Veevers J, Peter AK, Manso AM, Bradford WH, Dalton ND, Peterson KL, Knowlton KU, Ross RS, Zhou X, Chen J. PMID: 27502369.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. Lmo7 is dispensable for skeletal muscle and cardiac function. Am J Physiol Cell Physiol. 2015 Oct 01; 309(7):C470-9. Lao DH, Esparza MC, Bremner SN, Banerjee I, Zhang J, Veevers J, Bradford WH, Gu Y, Dalton ND, Knowlton KU, Peterson KL, Lieber RL, Chen J. PMID: 26157009.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    32. Prevalence of coronary artery-pulmonary artery collaterals in patients with chronic thromboembolic pulmonary hypertension. Pulm Circ. 2015 Jun; 5(2):313-21. Lee NS, Blanchard DG, Knowlton KU, McDivit AM, Pretorius V, Madani MM, Fedullo PF, Kerr KM, Kim NH, Poch DS, Auger WR, Daniels LB. PMID: 26064456.
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    33. Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy. J Clin Invest. 2013 Dec; 123(12):5146-51. Lim BK, Peter AK, Xiong D, Narezkina A, Yung A, Dalton ND, Hwang KK, Yajima T, Chen J, Knowlton KU. PMID: 24200690.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol. 2012 Feb 28; 59(9):838-52. Oba T, Yasukawa H, Hoshijima M, Sasaki K, Futamata N, Fukui D, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Minami T, Nakamura K, Kang D, Yajima T, Knowlton KU, Imaizumi T. PMID: 22361405.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    35. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19413-8. Blasius AL, Dubin AE, Petrus MJ, Lim BK, Narezkina A, Criado JR, Wills DN, Xia Y, Moresco EM, Ehlers C, Knowlton KU, Patapoutian A, Beutler B. PMID: 22087007.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    36. Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias. Circulation. 2011 Dec 13; 124(24):2690-701. Yajima T, Murofushi Y, Zhou H, Park S, Housman J, Zhong ZH, Nakamura M, Machida M, Hwang KK, Gu Y, Dalton ND, Yajima T, Yasukawa H, Peterson KL, Knowlton KU. PMID: 22082679.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    37. The costamere bridges sarcomeres to the sarcolemma in striated muscle. Prog Pediatr Cardiol. 2011 May; 31(2):83-88. Peter AK, Cheng H, Ross RS, Knowlton KU, Chen J. PMID: 24039381.
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    38. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet. 2011 May 01; 20(9):1751-62. Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton KU, Sheikh F, Chen J. PMID: 21303826.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    39. Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res. 2010 Aug 06; 107(3):348-56. Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans SM, Knowlton KU, Peterson KL, Chen J. PMID: 20538684.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    40. Viral myocarditis: from the perspective of the virus. Circulation. 2009 May 19; 119(19):2615-24. Yajima T, Knowlton KU. PMID: 19451363.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    41. Viral myocarditis: is infection of the heart required? J Am Coll Cardiol. 2009 Apr 07; 53(14):1227-8. Knowlton KU, Lim BK. PMID: 19341865.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    42. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug; 118(8):2758-70. Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU. PMID: 18636119.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    43. CVB infection and mechanisms of viral cardiomyopathy. Curr Top Microbiol Immunol. 2008; 323:315-35. Knowlton KU. PMID: 18357777.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    44. Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H69-76. Wang YX, da Cunha V, Vincelette J, White K, Velichko S, Xu Y, Gross C, Fitch RM, Halks-Miller M, Larsen BR, Yajima T, Knowlton KU, Vergona R, Sullivan ME, Croze E. PMID: 17434974.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    45. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation. 2007 Jan 02; 115(1):94-102. Xiong D, Yajima T, Lim BK, Stenbit A, Dublin A, Dalton ND, Summers-Torres D, Molkentin JD, Duplain H, Wessely R, Chen J, Knowlton KU. PMID: 17190866.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    46. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. PMID: 17101849.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    47. alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation. 2006 Sep 05; 114(10):1046-55. Sheikh F, Chen Y, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard JC, Chen J. PMID: 16923756.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    48. Treatment of coxsackievirus-B3-infected BALB/c mice with the soluble coxsackie adenovirus receptor CAR4/7 aggravates cardiac injury. J Mol Med (Berl). 2006 Oct; 84(10):842-51. Dörner A, Grunert HP, Lindig V, Chandrasekharan K, Fechner H, Knowlton KU, Isik A, Pauschinger M, Zeichhardt H, Schultheiss HP. PMID: 16924471.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    49. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science. 2006 Jul 07; 313(5783):94-7. Trifilo MJ, Yajima T, Gu Y, Dalton N, Peterson KL, Race RE, Meade-White K, Portis JL, Masliah E, Knowlton KU, Chesebro B, Oldstone MB. PMID: 16825571.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    50. Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol. 2006 Jun 19; 173(6):905-16. Bang ML, Li X, Littlefield R, Bremner S, Thor A, Knowlton KU, Lieber RL, Chen J. PMID: 16769824.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    51. Unsolved medical issues and new targets for further research in viral myocarditis and dilated cardiomyopathy. Ernst Schering Res Found Workshop. 2006; (55):19-35. Knowlton KU. PMID: 16329655.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    52. Long-term cardiac gene expression using a coxsackieviral vector. J Mol Cell Cardiol. 2005 May; 38(5):745-51. Lim BK, Shin JO, Lee SC, Kim DK, Choi DJ, Choe SC, Knowlton KU, Jeon ES. PMID: 15850568.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    53. Highlights of the year in JACC 2004. J Am Coll Cardiol. 2005 Jan 04; 45(1):137-53. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Narula J, Sahn D, Tsimikas S. PMID: 15629388.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    54. Interleukin-10: biomarker or pathologic cytokine in fulminant myocarditis? J Am Coll Cardiol. 2004 Sep 15; 44(6):1298-300. Knowlton KU, Yajima T. PMID: 15364335.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    55. Chronic thromboembolic pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):453-66, vii. Auger WR, Kerr KM, Kim NH, Ben-Yehuda O, Knowlton KU, Fedullo PF. PMID: 15302364.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    56. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. J Biol Chem. 2004 Apr 30; 279(18):18497-503. Dörner A, Xiong D, Couch K, Yajima T, Knowlton KU. PMID: 14978041.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    57. Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Circulation. 2004 Jan 06; 109(1):18-22. Kim NH, Fesler P, Channick RN, Knowlton KU, Ben-Yehuda O, Lee SH, Naeije R, Rubin LJ. PMID: 14699009.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    58. Highlights of the year in JACC 2003. J Am Coll Cardiol. 2003 Dec 17; 42(12):2156-66. DeMaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Tsimikas S. PMID: 15560019.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    59. Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside. Med Microbiol Immunol. 2004 May; 193(2-3):121-6. Badorff C, Knowlton KU. PMID: 12920582.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    60. Electrocardiographic manifestations: wide complex tachycardia due to accessory pathway. J Emerg Med. 2003 Apr; 24(3):295-301. Nelson JA, Knowlton KU, Harrigan R, Pollack ML, Chan TC. PMID: 12676301.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    61. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. PMID: 12588885.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    62. Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by Coxsackievirus 2A protease. J Biol Chem. 2003 Feb 14; 278(7):4449-57. Zhao X, Lamphear BJ, Xiong D, Knowlton K, Rhoads RE. PMID: 12475969.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    63. Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. Nat Med. 2002 Aug; 8(8):872-7. Xiong D, Lee GH, Badorff C, Dorner A, Lee S, Wolf P, Knowlton KU. PMID: 12118246.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    64. Apoptosis and oncosis in the early progression of left ventricular dysfunction in the cardiomyopathic hamster. Basic Res Cardiol. 2002 Jan; 97(1):65-75. Ryoke T, Gu Y, Ikeda Y, Martone ME, Oh SS, Jeon ES, Knowlton KU, Ross J. PMID: 12004790.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    65. Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling: implications for mortality and early viral replication. Circulation. 2001 Feb 06; 103(5):756-61. Wessely R, Klingel K, Knowlton KU, Kandolf R. PMID: 11156890.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    66. The immune response following myocardial infarction: a role for T-cell-mediated myocyte damage. J Mol Cell Cardiol. 2000 Dec; 32(12):2107-10. Knowlton KU. PMID: 11112986.
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    67. Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: A protective mechanism against enteroviral cardiomyopathy. Circulation. 2000 Oct 31; 102(18):2276-81. Badorff C, Fichtlscherer B, Rhoads RE, Zeiher AM, Muelsch A, Dimmeler S, Knowlton KU. PMID: 11056105.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    68. Dissociation of sarcoglycans and the dystrophin carboxyl terminus from the sarcolemma in enteroviral cardiomyopathy. Circ Res. 2000 Sep 15; 87(6):489-95. Lee GH, Badorff C, Knowlton KU. PMID: 10988241.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    69. Enteroviral cardiomyopathy: bad news for the dystrophin-glycoprotein complex. Herz. 2000 May; 25(3):227-32. Badorff C, Lee GH, Knowlton KU. PMID: 10904843.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    70. Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue. J Biol Chem. 2000 Apr 14; 275(15):11191-7. Badorff C, Berkely N, Mehrotra S, Talhouk JW, Rhoads RE, Knowlton KU. PMID: 10753926.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    71. Inflammatory pathways and cardiac repair: the affliction of infarction. Nat Med. 1999 Oct; 5(10):1122-3. Knowlton KU, Chien KR. PMID: 10502807.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    72. The immune system in viral myocarditis: maintaining the balance. Circ Res. 1999 Sep 17; 85(6):559-61. Knowlton KU, Badorff C. PMID: 10488059.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    73. Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat Med. 1999 Mar; 5(3):320-6. Badorff C, Lee GH, Lamphear BJ, Martone ME, Campbell KP, Rhoads RE, Knowlton KU. PMID: 10086389.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    74. Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? J Virol. 1999 Jan; 73(1):709-17. Kerekatte V, Keiper BD, Badorff C, Cai A, Knowlton KU, Rhoads RE. PMID: 9847377.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    75. Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy. J Clin Invest. 1998 Oct 01; 102(7):1444-53. Wessely R, Klingel K, Santana LF, Dalton N, Hongo M, Jonathan Lederer W, Kandolf R, Knowlton KU. PMID: 9769337.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    76. Low-level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes. Circulation. 1998 Aug 04; 98(5):450-7. Wessely R, Henke A, Zell R, Kandolf R, Knowlton KU. PMID: 9714096.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    77. NF-kappaB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout mice. J Virol. 1998 Jul; 72(7):5654-60. Schwarz EM, Badorff C, Hiura TS, Wessely R, Badorff A, Verma IM, Knowlton KU. PMID: 9621024.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    78. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem. 1997 Feb 28; 272(9):5783-91. Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR. PMID: 9038192.
      View in: PubMed   Mentions: 59     Fields:    Translation:Animals
    79. Alpha 1-adrenergic stimulation inhibits 3,5,3'-triiodothyronine-induced expression of the rat heart sarcoplasmic reticulum Ca2+ adenosine triphosphatase gene. Endocrinology. 1997 Jan; 138(1):114-20. Wu PS, Moriscot AS, Knowlton KU, Hilal-Dandan R, He H, Dillmann WH. PMID: 8977393.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    80. A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3. J Virol. 1996 Nov; 70(11):7811-8. Knowlton KU, Jeon ES, Berkley N, Wessely R, Huber S. PMID: 8892902.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    81. Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. J Clin Invest. 1995 Sep; 96(3):1311-8. Knowlton KU, Rockman HA, Itani M, Vovan A, Seidman CE, Chien KR. PMID: 7657806.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    82. Regulated expression of a contractile protein gene correlates with recovery of contractile function after reversible metabolic inhibition in cultured myocytes. J Mol Cell Cardiol. 1995 Jan; 27(1):551-61. Barry WH, Hamilton CA, Knowlton KU. PMID: 7760376.
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    83. Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. J Biol Chem. 1994 May 06; 269(18):13490-6. LaMorte VJ, Thorburn J, Absher D, Spiegel A, Brown JH, Chien KR, Feramisco JR, Knowlton KU. PMID: 8175782.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    84. The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 1993 Jul 25; 268(21):15374-80. Knowlton KU, Michel MC, Itani M, Shubeita HE, Ishihara K, Brown JH, Chien KR. PMID: 8393439.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    85. Transcriptional regulation during cardiac growth and development. Annu Rev Physiol. 1993; 55:77-95. Chien KR, Zhu H, Knowlton KU, Miller-Hance W, van-Bilsen M, O'Brien TX, Evans SM. PMID: 8466192.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    86. Peripartum vascular collapse Dissection of a genetic disease. Trends Cardiovasc Med. 1992 Jul-Aug; 2(4):125-8. Rockman HA, Knowlton KU. PMID: 21239257.
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    87. Two brothers with unexplained cardiomegaly Initial clues to the molecular basis of a hereditary cardiac disease. Trends Cardiovasc Med. 1992 Jan-Feb; 2(1):2-5. Ross RS, Knowlton KU. PMID: 21239280.
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    88. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J. 1991 Dec; 5(15):3037-46. Chien KR, Knowlton KU, Zhu H, Chien S. PMID: 1835945.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    89. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8277-81. Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, Ross J, Chien KR. PMID: 1832775.
      View in: PubMed   Mentions: 239     Fields:    Translation:AnimalsCells
    90. Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. J Biol Chem. 1991 Apr 25; 266(12):7759-68. Knowlton KU, Baracchini E, Ross RS, Harris AN, Henderson SA, Evans SM, Glembotski CC, Chien KR. PMID: 1850419.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    91. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 1990 Nov 25; 265(33):20555-62. Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotski CC, Brown JH, Chien KR. PMID: 2173712.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    92. Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. J Clin Invest. 1990 Feb; 85(2):462-7. Maisel AS, Knowlton KU, Fowler P, Rearden A, Ziegler MG, Motulsky HJ, Insel PA, Michel MC. PMID: 2153706.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    93. Cardiovascular molecular biology. Introduction to the series. Circulation. 1989 Aug; 80(2):219-33. Chien KR, Knowlton KU. PMID: 2502325.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    94. Catheter-directed neodymium:YAG laser injury of the left ventricle for arrhythmia ablation: dosimetry and hemodynamic, hematologic, and electrophysiologic effects. Lasers Surg Med. 1989; 9(5):446-53. Vincent GM, Fox J, Knowlton K, Dixon JA. PMID: 2811567.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    95. The effect of adrenal stimulation with adrenocorticotrophic hormone on the excretion of dehydroisoandrosterone in man. Endocrinology. 1951 May; 48(5):489-505. LANDAU RL, KNOWLTON K, LUGIBIHL K, KENYON AT. PMID: 14840409.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    96. The determination of urinary dehydroisoandrosterone in normal men and women and in adrenal disease. Endocrinology. 1951 May; 48(5):506-17. LANDAU RL, KNOWLTON K, LUGIBIHL K, MUNSON PL. PMID: 14840410.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    97. The significance of urinary dehydroisoandrosterone. J Clin Invest. 1950 Jun; 29(6):829-30. LANDAU RL, KNOWLTON K, LUGIBIHL K. PMID: 15436777.
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    98. The anabolic effects of chorionic gonadotropin in normal young men. J Clin Invest. 1950 May; 29(5):619-29. LANDAU RL, KNOWLTON K, LUGIBIHL K, BRANDT M, KENYON AT. PMID: 15415466.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    99. The metabolic effects of chorionic gonadotrophins in young men. J Clin Invest. 1948 Jul; 27(4):545. LANDAU RL, KNOWLTON K. PMID: 18935175.
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    100. STUDIES ON EXPERIMENTAL AND CLINICAL HYPOCHLOREMIA IN MAN. J Clin Invest. 1943 Jan; 22(1):95-102. Kirsner JB, Palmer WL, Knowlton K. PMID: 16694984.
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    101. ACID-BASE BALANCE, RENAL FUNCTION, AND GASTRIC SECRETION DURING HYPOCHLOREMIA IN THE DOG. J Clin Invest. 1941 May; 20(3):303-12. Kirsner JB, Knowlton K. PMID: 16694836.
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