Kirk Knowlton

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of mTOR, a Component of the Akt Pathway, in Regulating Cardiac Function
    NIH R01HL078797Dec 1, 2004 - Nov 30, 2015
    Role: Principal Investigator
    Dystrophin-glycoprotein complex in viral cardiomyopathy
    NIH R01HL066424Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    Cardiac SOCS Proteins: A Role in Enterovirus Infection
    NIH R01HL057365Dec 5, 1998 - Apr 30, 2009
    Role: Principal Investigator
    NIH P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Co-Investigator
    NIH K08HL002618Aug 1, 1991 - Jul 31, 1997
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    Training in Cardiovascular Physiology and Pharmacology
    NIH T32HL007444Jul 1, 1979 - Jun 30, 2023
    Role: Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH P01HL046345Jun 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Insights From a Murine Model of Coronavirus Disease 2019 (COVID-19) mRNA Vaccination-Induced Myopericarditis: Could Accidental Intravenous Vaccine Injection Induce Myopericarditis? Clin Infect Dis. 2022 06 10; 74(11):1951-1952. Knowlton KU. PMID: 34453510.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsPHPublic Health
    2. High-statin adherence over 5 years of follow-up is associated with improved cardiovascular outcomes in patients with atherosclerotic cardiovascular disease: results from the IMPRES study. Eur Heart J Qual Care Clin Outcomes. 2022 05 05; 8(3):352-360. May HT, Knowlton KU, Anderson JL, Lappé DL, Bair TL, Muhlestein JB. PMID: 33787865.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. Eur Heart J. 2022 05 01; 43(17):1668-1680. Roselli C, Yu M, Nauffal V, Georges A, Yang Q, Love K, Weng LC, Delling FN, Maurya SR, Schrölkamp M, Tfelt-Hansen J, Hagège A, Jeunemaitre X, Debette S, Amouyel P, Guan W, Muehlschlegel JD, Body SC, Shah S, Samad Z, Kyryachenko S, Haynes C, Rienstra M, Le Tourneau T, Probst V, Roussel R, Wijdh-Den Hamer IJ, Siland JE, Knowlton KU, Jacques Schott J, Levine RA, Benjamin EJ, Vasan RS, Horne BD, Muhlestein JB, Benfari G, Enriquez-Sarano M, Natale A, Mohanty S, Trivedi C, Shoemaker MB, Yoneda ZT, Wells QS, Baker MT, Farber-Eger E, Michelena HI, Lundby A, Norris RA, Slaugenhaupt SA, Dina C, Lubitz SA, Bouatia-Naji N, Ellinor PT, Milan DJ. PMID: 35245370.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Real-world clinical burden and economic assessment associated with hyperkalaemia in a large integrated healthcare system: a retrospective analysis. BMC Prim Care. 2022 04 01; 23(1):65. Muhlestein JB, Kammerer J, Bair TL, Knowlton KU, Le VT, Anderson JL, Lappé DL, May HT. PMID: 35365076; PMCID: PMC8974122.
      View in: PubMed   Mentions: Translation:Humans
    5. Association of the Intermountain Risk Score with major adverse health events in patients positive for COVID-19: an observational evaluation of a US cohort. BMJ Open. 2022 03 24; 12(3):e053864. Horne BD, Bledsoe JR, Muhlestein JB, May HT, Peltan ID, Webb BJ, Carlquist JF, Bennett ST, Rea S, Bair TL, Grissom CK, Knight S, Ronnow BS, Le VT, Stenehjem E, Woller SC, Knowlton KU, Anderson JL. PMID: 35332038; PMCID: PMC8948080.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Intermittent fasting and changes in Galectin-3: A secondary analysis of a randomized controlled trial of disease-free subjects. Nutr Metab Cardiovasc Dis. 2022 06; 32(6):1538-1548. Horne BD, Anderson JL, May HT, Le VT, Galenko O, Drakos SG, Bair TL, Knowlton KU, Muhlestein JB. PMID: 35361560.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Association of Rhesus factor blood type with risk of SARS-CoV-2 infection and COVID-19 severity. Br J Haematol. 2022 06; 197(5):573-575. Anderson JL, May HT, Knight S, Bair TL, Horne BD, Knowlton KU. PMID: 35106763.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Association of periodic fasting lifestyles with survival and incident major adverse cardiovascular events in patients undergoing cardiac catheterization. Eur J Prev Cardiol. 2022 01 11; 28(16):1774-1781. Bartholomew CL, Muhlestein JB, Anderson JL, May HT, Knowlton KU, Bair TL, Le VT, Bailey BW, Horne BD. PMID: 33624026.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    9. Insulin Growth Factor Phenotypes in Heart Failure With Preserved Ejection Fraction, an INSPIRE Registry and CATHGEN Study. J Card Fail. 2022 06; 28(6):935-946. Haddad F, Ataam JA, Amsallem M, Cauwenberghs N, Kuznetsova T, Rosenberg-Hasson Y, Zamanian RT, Karakikes I, Horne BD, Muhlestein JB, Kwee L, Shah S, Maecker H, Knight S, Knowlton K. PMID: 34979242.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. A Small but Significantly Greater Incidence of Inflammatory Heart Disease Identified After Vaccination for Severe Acute Respiratory Syndrome Coronavirus 2. Open Forum Infect Dis. 2022 Mar; 9(3):ofab663. Knowlton KU, Knight S, Muhlestein JB, Le VT, Horne BD, May HT, Stenehjem EA, Anderson JL. PMID: 35141346; PMCID: PMC8755376.
      View in: PubMed   Mentions: 1  
    11. Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial. Ann Intern Med. 2022 02; 175(2):234-243. ACTIV-3/TICO Bamlanivimab Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Goodman AL, Chang W, Dewar RL, Gerry NP, Higgs ES, Highbarger H, Murray DD, Murray TA, Natarajan V, Paredes R, Parmar MKB, Phillips AN, Reilly C, Rupert AW, Sharma S, Shaw-Saliba K, Sherman BT, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Davey VJ, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD. PMID: 34928698; PMCID: PMC9334931.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    12. Coronary Artery Calcium Versus Pooled Cohort Equations Score for Primary Prevention Guidance: Randomized Feasibility Trial. JACC Cardiovasc Imaging. 2022 05; 15(5):843-855. Muhlestein JB, Knowlton KU, Le VT, Lappe DL, May HT, Min DB, Johnson KM, Cripps ST, Schwab LH, Braun SB, Bair TL, Anderson JL. PMID: 34922872.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    13. Preferential Metabolic Improvement by Intermittent Fasting in People with Elevated Baseline Red Cell Distribution Width: A Secondary Analysis of the WONDERFUL Randomized Controlled Trial. Nutrients. 2021 Dec 09; 13(12). Horne BD, Muhlestein JB, May HT, Le VT, Bair TL, Bennett ST, Knowlton KU, Anderson JL. PMID: 34959959; PMCID: PMC8703681.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Behavioral Nudges as Patient Decision Support for Medication Adherence: The ENCOURAGE Randomized Controlled Trial. Am Heart J. 2022 02; 244:125-134. Horne BD, Muhlestein JB, Lappé DL, May HT, Le VT, Bair TL, Babcock D, Bride D, Knowlton KU, Anderson JL. PMID: 34798073.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo. Commun Biol. 2021 10 07; 4(1):1148. Skuladottir AT, Bjornsdottir G, Nawaz MS, Petersen H, Rognvaldsson S, Moore KHS, Olafsson PI, Magnusson SH, Bjornsdottir A, Sveinsson OA, Sigurdardottir GR, Saevarsdottir S, Ivarsdottir EV, Stefansdottir L, Gunnarsson B, Muhlestein JB, Knowlton KU, Jones DA, Nadauld LD, Hartmann AM, Rujescu D, Strupp M, Walters GB, Thorgeirsson TE, Jonsdottir I, Holm H, Thorleifsson G, Gudbjartsson DF, Sulem P, Stefansson H, Stefansson K. PMID: 34620984; PMCID: PMC8497462.
      View in: PubMed   Mentions: 2  Translation:Humans
    16. Absent or Mild Coronary Calcium Predicts Low-Risk Stress Test Results and Outcomes in Patients Considered for Flecainide Therapy. J Cardiovasc Pharmacol Ther. 2021 11; 26(6):648-655. Anderson JL, Knight S, McCubrey RO, May HT, Mason S, Bunch TJ, Min DB, Cutler MJ, Le VT, Muhlestein JB, Knowlton KU. PMID: 34546822.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Long-term outcomes in patients treated with flecainide for atrial fibrillation with stable coronary artery disease. Am Heart J. 2022 01; 243:127-139. Burnham TS, May HT, Bair TL, Anderson JA, Crandall BG, Cutler MJ, Day JD, Freedman RA, Knowlton KU, Muhlestein JB, Navaravong L, Ranjan RA, Steinberg BA, Bunch TJ. PMID: 34537183.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Depression as a Driving Force for Low Time in Therapeutic Range and Dementia in Patients With and Without Atrial Fibrillation. Am J Cardiol. 2021 08 15; 153:58-64. Rizzi SA, Knight S, May HT, Woller SC, Stevens SM, Steinberg BA, Bair TL, Anderson JL, Muhlestein JB, Knowlton KU, Bunch TJ. PMID: 34176597.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. External validation of integrated genetic-epigenetic biomarkers for predicting incident coronary heart disease. Epigenomics. 2021 07; 13(14):1095-1112. Dogan MV, Knight S, Dogan TK, Knowlton KU, Philibert R. PMID: 34148365; PMCID: PMC8356680.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Simplifying the ISCHEMIA trial algorithm for clinical practice: Identifying left main coronary artery disease using coronary artery calcium scans. Am Heart J. 2021 09; 239:129-134. Money JE, Muhlestein JB, Mason S, Bair TL, Knowlton KU, Horne BD, Anderson JL. PMID: 34051172.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease. N Engl J Med. 2021 05 27; 384(21):1981-1990. Jones WS, Mulder H, Wruck LM, Pencina MJ, Kripalani S, Muñoz D, Crenshaw DL, Effron MB, Re RN, Gupta K, Anderson RD, Pepine CJ, Handberg EM, Manning BR, Jain SK, Girotra S, Riley D, DeWalt DA, Whittle J, Goldberg YH, Roger VL, Hess R, Benziger CP, Farrehi P, Zhou L, Ford DE, Haynes K, VanWormer JJ, Knowlton KU, Kraschnewski JL, Polonsky TS, Fintel DJ, Ahmad FS, McClay JC, Campbell JR, Bell DS, Fonarow GC, Bradley SM, Paranjape A, Roe MT, Robertson HR, Curtis LH, Sharlow AG, Berdan LG, Hammill BG, Harris DF, Qualls LG, Marquis-Gravel G, Modrow MF, Marcus GM, Carton TW, Nauman E, Waitman LR, Kho AN, Shenkman EA, McTigue KM, Kaushal R, Masoudi FA, Antman EM, Davidson DR, Edgley K, Merritt JG, Brown LS, Zemon DN, McCormick TE, Alikhaani JD, Gregoire KC, Rothman RL, Harrington RA, Hernandez AF, ADAPTABLE Team. PMID: 33999548.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    22. Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population. JAMA Netw Open. 2021 04 01; 4(4):e217429. Anderson JL, May HT, Knight S, Bair TL, Muhlestein JB, Knowlton KU, Horne BD. PMID: 33818622; PMCID: PMC8022215.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. SARS-CoV-2 as an inflammatory cardiovascular disease: current knowledge and future challenges. Future Cardiol. 2021 10; 17(7):1277-1291. Shah KS, Hale Hammond ME, Drakos SG, Anderson JL, Fang JC, Knowlton KU, Shaw RM. PMID: 33739142; PMCID: PMC7986052.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    24. Vitamin D supplementation protects against reductions in plasma 25-hydroxyvitamin D induced by open-heart surgery: Assess-d trial. Physiol Rep. 2021 02; 9(3):e14747. Barker T, May HT, Doty JR, Lappe DL, Knowlton KU, Carlquist J, Konery K, Inglet S, Chisum B, Galenko O, Anderson JL, Muhlestein JB. PMID: 33580636; PMCID: PMC7881347.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Evaluation of TReatment With Angiotensin Converting Enzyme Inhibitors and the Risk of Lung Cancer: ERACER-An Observational Cohort Study. J Cardiovasc Pharmacol Ther. 2021 07; 26(4):321-327. Anderson JL, Knowlton KU, Muhlestein JB, Bair TL, Le VT, Horne BD. PMID: 33514290.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. N Engl J Med. 2021 03 11; 384(10):905-914. ACTIV-3/TICO LY-CoV555 Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Davey VJ, Goodman A, Higgs ES, Murray DD, Murray TA, Paredes R, Parmar MKB, Phillips AN, Reilly C, Sharma S, Dewar RL, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD. PMID: 33356051; PMCID: PMC7781100.
      View in: PubMed   Mentions: 141     Fields:    Translation:Humans
    27. Frequency and clinical impact of hyperkalaemia within a large, modern, real-world heart failure population. ESC Heart Fail. 2021 02; 8(1):691-696. Muhlestein JB, Kammerer J, Bair TL, Knowlton KU, Le VT, Anderson JL, Lappé DL, May HT. PMID: 33331114; PMCID: PMC7835576.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Spectrum of radionuclide perfusion study abnormalities in takotsubo cardiomyopathy. J Nucl Cardiol. 2022 06; 29(3):1034-1046. Anderson JL, Horne BD, Le VT, Bair TL, Min DB, Minder CM, Dhar R, Mason S, Muhlestein JB, Knowlton KU. PMID: 33090340.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Discovery of TITIN Gene Truncating Variant Mutations and 5-Year Outcomes in Patients With Nonischemic Dilated Cardiomyopathy. Am J Cardiol. 2020 12 15; 137:97-102. Anderson JL, Christensen GB, Escobar H, Horne BD, Knight S, Jacobs V, Afshar K, Hebl VB, Muhlestein JB, Knowlton KU, Carlquist JF, Nadauld LD. PMID: 32998006.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Evaluation of Routine Coronary Angiography Before Pulmonary Thromboendarterectomy. Ann Thorac Surg. 2021 05; 111(5):1703-1709. Pandey AK, Lee NS, Marsal J, Knowlton KU, McDivit AM, Blanchard DG, Pretorius V, Madani MM, Fedullo PF, Kerr KM, Kim NH, Fernandes TM, Poch DS, Auger WR, Daniels LB. PMID: 32896544.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Pathogenesis of SARS-CoV-2 induced cardiac injury from the perspective of the virus. J Mol Cell Cardiol. 2020 10; 147:12-17. Knowlton KU. PMID: 32771409; PMCID: PMC7409803.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCellsPHPublic Health
    32. How Community-Based Health Systems Embrace Research During the COVID-19 Pandemic. Qual Manag Health Care. 2020 Jul/Sep; 29(3):173-175. Brunisholz KD, Knighton AJ, Webb B, Brown SM, Peltan ID, Stenehjem E, Knowlton K, Belnap TW, Quam J, Srivastava R, Intermountain Healthcare Research Guidance Council. PMID: 32590494.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    33. Intermountain chronic disease risk score (ICHRON) validation for prediction of incident chronic disease diagnoses in an australian primary prevention population. Eur J Intern Med. 2020 09; 79:81-87. May HT, Anderson JL, Muhlestein JB, Knowlton KU, Horne BD. PMID: 32563688.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    34. Predictors of Statin Intolerance in Patients With a New Diagnosis of Atherosclerotic Cardiovascular Disease Within a Large Integrated Health Care Institution: The IMPRES Study. J Cardiovasc Pharmacol. 2020 05; 75(5):426-431. Bair TL, May HT, Knowlton KU, Anderson JL, Lappe DL, Muhlestein JB. PMID: 32079856.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function. Circ Res. 2020 07 03; 127(2):284-297. Zhang J, Vincent KP, Peter AK, Klos M, Cheng H, Huang SM, Towne JK, Ferng D, Gu Y, Dalton ND, Chan Y, Li R, Peterson KL, Chen J, McCulloch AD, Knowlton KU, Ross RS. PMID: 32345129; PMCID: PMC7571547.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    36. Absence of Coronary Artery Calcium During Positron Emission Tomography Stress Testing in Patients Without Known Coronary Artery Disease Identifies Individuals With Very Low Risk of Cardiac Events. Circ Cardiovasc Imaging. 2020 01; 13(1):e009907. Le VT, Knight S, Min DB, McCubrey RO, Horne BD, Jensen KR, Meredith KG, Mason SM, Lappé DL, Anderson JL, Muhlestein JB, Knowlton KU. PMID: 31959008.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Free thyroxine within the normal reference range predicts risk of atrial fibrillation. J Cardiovasc Electrophysiol. 2020 01; 31(1):18-29. Anderson JL, Jacobs V, May HT, Bair TL, Benowitz BA, Lappe DL, Muhlestein JB, Knowlton KU, Bunch TJ. PMID: 31515856.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    38. Comparison of Three Atherosclerotic Cardiovascular Disease Risk Scores With and Without Coronary Calcium for Predicting Revascularization and Major Adverse Coronary Events in Symptomatic Patients Undergoing Positron Emission Tomography-Stress Testing. Am J Cardiol. 2020 02 01; 125(3):341-348. Anderson JL, Le VT, Min DB, Biswas S, Minder CM, McCubrey RO, Knight S, Horne BD, Mason S, Lappe DL, Muhlestein JB, Knowlton KU. PMID: 31806210.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Value of Neutrophil to Lymphocyte Ratio and Its Trajectory in Patients Hospitalized With Acute Heart Failure and Preserved Ejection Fraction. Am J Cardiol. 2020 01 15; 125(2):229-235. Boralkar KA, Kobayashi Y, Amsallem M, Ataam JA, Moneghetti KJ, Cauwenberghs N, Horne BD, Knowlton KU, Maecker H, Kuznetsova T, Heidenreich PA, Haddad F. PMID: 31753313.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    40. Circulating Levels of Biomarkers of Cerebral Injury in Patients with Atrial Fibrillation. Am J Cardiol. 2019 12 01; 124(11):1697-1700. Galenko O, Jacobs V, Knight S, Bride D, Cutler MJ, Muhlestein JB, Carlquist JL, Anderson JL, Knowlton KU, Jared Bunch T. PMID: 31575426.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. Approaching Higher Dimension Imaging Data Using Cluster-Based Hierarchical Modeling in Patients with Heart Failure Preserved Ejection Fraction. Sci Rep. 2019 07 18; 9(1):10431. Kobayashi Y, Tremblay-Gravel M, Boralkar KA, Li X, Nishi T, Amsallem M, Moneghetti KJ, Bouajila S, Selej M, Ozen MO, Demirci U, Ashley E, Wheeler M, Knowlton KU, Kouznetsova T, Haddad F. PMID: 31320698; PMCID: PMC6639369.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    42. Improving risk stratification in heart failure with preserved ejection fraction by combining two validated risk scores. Open Heart. 2019; 6(1):e000961. Boralkar KA, Kobayashi Y, Moneghetti KJ, Pargaonkar VS, Tuzovic M, Krishnan G, Wheeler MT, Banerjee D, Kuznetsova T, Horne BD, Knowlton KU, Heidenreich PA, Haddad F. PMID: 31217994; PMCID: PMC6546198.
      View in: PubMed   Mentions: 7     Fields:    
    43. Dilated Cardiomyopathy. Circulation. 2019 05 14; 139(20):2339-2341. Knowlton KU. PMID: 31082299.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    44. Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture. Circulation. 2019 03 19; 139(12):1554-1556. Zhang Z, Mu Y, Zhang J, Zhou Y, Cattaneo P, Veevers J, Peter AK, Manso AM, Knowlton KU, Zhou X, Evans SM, Ross RS, Chen J. PMID: 30883226; PMCID: PMC6424132.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    45. Safety and Efficacy of Periprocedural Heparin Plus a Short-Term Infusion of Tirofiban Versus Bivalirudin Monotherapy in Patients Who Underwent Percutaneous Coronary Intervention (from the Intermountain Heart Institute STAIR Observational Registry). Am J Cardiol. 2019 06 15; 123(12):1927-1934. Muhlestein JB, Hackett IS, May HT, Bair TL, Le VT, Anderson JL, Whisenant B, Knowlton KU, Lappé DL. PMID: 30981419.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. The role of microRNAs in the development, regulation, and treatment of atrial fibrillation. J Interv Card Electrophysiol. 2019 Sep; 55(3):297-305. Galenko O, Jacobs V, Knight S, Taylor M, Cutler MJ, Muhlestein JB, Carlquist JL, Knowlton KU, Jared Bunch T. PMID: 30607665.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    47. CHA2DS2-VASc scores and Intermountain Mortality Risk Scores for the joint risk stratification of dementia among patients with atrial fibrillation. Heart Rhythm. 2019 01; 16(1):3-9. Graves KG, May HT, Jacobs V, Knowlton KU, Muhlestein JB, Lappe DL, Anderson JL, Horne BD, Bunch TJ. PMID: 30611392.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    48. Prediction of Long-Term Incidence of Chronic Cardiovascular and Cardiopulmonary Diseases in Primary Care Patients for Population Health Monitoring: The Intermountain Chronic Disease Model (ICHRON). Mayo Clin Proc. 2019 07; 94(7):1221-1230. May HT, Lappé DL, Knowlton KU, Muhlestein JB, Anderson JL, Horne BD. PMID: 30577973.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    49. Improving CHA2DS2-VASc stratification of non-fatal stroke and mortality risk using the Intermountain Mortality Risk Score among patients with atrial fibrillation. Open Heart. 2018; 5(2):e000907. Graves KG, May HT, Knowlton KU, Muhlestein JB, Jacobs V, Lappé DL, Anderson JL, Horne BD, Bunch TJ. PMID: 30564375; PMCID: PMC6269639.
      View in: PubMed   Mentions: 3     Fields:    
    50. Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells. Stem Cell Reports. 2018 09 11; 11(3):828-841. Veevers J, Farah EN, Corselli M, Witty AD, Palomares K, Vidal JG, Emre N, Carson CT, Ouyang K, Liu C, van Vliet P, Zhu M, Hegarty JM, Deacon DC, Grinstein JD, Dirschinger RJ, Frazer KA, Adler ED, Knowlton KU, Chi NC, Martin JC, Chen J, Evans SM. PMID: 30122443; PMCID: PMC6135222.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    51. Extreme erythrocyte macrocytic and microcytic percentages are highly predictive of morbidity and mortality. JCI Insight. 2018 07 26; 3(14). Horne BD, Muhlestein JB, Bennett ST, Muhlestein JB, Jensen KR, Marshall D, Bair TL, May HT, Carlquist JF, Hegewald M, Knight S, Le VT, Bunch TJ, Lappé DL, Anderson JL, Knowlton KU. PMID: 30046011; PMCID: PMC6124438.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    52. How Community-Based Health Systems Can Embrace Research in the Fee-for-Value Era. Qual Manag Health Care. 2018 Jul/Sep; 27(3):180-182. Knighton AJ, Grissom CK, Knowlton KU, Sean Esplin M, Graydon T, Srivastava R, Intermountain Healthcare Research Guidance Council. PMID: 29944632.
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    53. Implementation of a cardiac PET stress program: comparison of outcomes to the preceding SPECT era. JCI Insight. 2018 05 03; 3(9). Knight S, Min DB, Le VT, Meredith KG, Dhar R, Biswas S, Jensen KR, Mason SM, Ethington JD, Lappe DL, Muhlestein JB, Anderson JL, Knowlton KU. PMID: 29720565; PMCID: PMC6012503.
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    54. GlycA and hsCRP are independent and additive predictors of future cardiovascular events among patients undergoing angiography: The intermountain heart collaborative study. Am Heart J. 2018 08; 202:27-32. Muhlestein JB, May HT, Galenko O, Knowlton KU, Otvos JD, Connelly MA, Lappe DL, Anderson JL. PMID: 29803983.
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    55. Temporal changes in statin prescription and intensity at discharge and impact on outcomes in patients with newly diagnosed atherosclerotic cardiovascular disease-Real-world experience within a large integrated health care system: The IMPRES study. J Clin Lipidol. 2018 Jul - Aug; 12(4):1008-1018.e1. Anderson JL, Knowlton KU, May HT, Bair TL, Armstrong SO, Lappé DL, Muhlestein JB. PMID: 29703626.
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    56. Real world MRI experience with nonconditional and conditional cardiac rhythm devices after MagnaSafe. J Cardiovasc Electrophysiol. 2017 Dec; 28(12):1468-1474. Mason S, Osborn JS, Dhar R, Tonkin A, Ethington JD, Le V, Benuzillo J, Lappe DL, Knowlton KU, Bunch TJ, Anderson JL. PMID: 28960745.
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    57. The association of depression at any time to the risk of death following coronary artery disease diagnosis. Eur Heart J Qual Care Clin Outcomes. 2017 10 01; 3(4):296-302. May HT, Horne BD, Knight S, Knowlton KU, Bair TL, Lappé DL, Le VT, Muhlestein JB. PMID: 28950317.
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    58. Myocarditis: An Intersection Between Genetic and Acquired Causes of Human Cardiomyopathy. J Am Coll Cardiol. 2017 04 04; 69(13):1666-1668. Knowlton KU. PMID: 28359510.
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    59. Increased Echogenicity and Radiodense Foci on Echocardiogram and MicroCT in Murine Myocarditis. PLoS One. 2016; 11(8):e0159971. Peter AK, Bradford WH, Dalton ND, Gu Y, Chao CJ, Peterson KL, Knowlton KU. PMID: 27486657; PMCID: PMC4972301.
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    60. Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. Circ Heart Fail. 2016 08; 9(8). Zhang Z, Mu Y, Veevers J, Peter AK, Manso AM, Bradford WH, Dalton ND, Peterson KL, Knowlton KU, Ross RS, Zhou X, Chen J. PMID: 27502369; PMCID: PMC4979611.
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    61. Lmo7 is dispensable for skeletal muscle and cardiac function. Am J Physiol Cell Physiol. 2015 Oct 01; 309(7):C470-9. Lao DH, Esparza MC, Bremner SN, Banerjee I, Zhang J, Veevers J, Bradford WH, Gu Y, Dalton ND, Knowlton KU, Peterson KL, Lieber RL, Chen J. PMID: 26157009; PMCID: PMC4593772.
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    62. Prevalence of coronary artery-pulmonary artery collaterals in patients with chronic thromboembolic pulmonary hypertension. Pulm Circ. 2015 Jun; 5(2):313-21. Lee NS, Blanchard DG, Knowlton KU, McDivit AM, Pretorius V, Madani MM, Fedullo PF, Kerr KM, Kim NH, Poch DS, Auger WR, Daniels LB. PMID: 26064456; PMCID: PMC4449242.
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    63. Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy. J Clin Invest. 2013 Dec; 123(12):5146-51. Lim BK, Peter AK, Xiong D, Narezkina A, Yung A, Dalton ND, Hwang KK, Yajima T, Chen J, Knowlton KU. PMID: 24200690; PMCID: PMC3859391.
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    64. Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol. 2012 Feb 28; 59(9):838-52. Oba T, Yasukawa H, Hoshijima M, Sasaki K, Futamata N, Fukui D, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Minami T, Nakamura K, Kang D, Yajima T, Knowlton KU, Imaizumi T. PMID: 22361405.
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    65. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19413-8. Blasius AL, Dubin AE, Petrus MJ, Lim BK, Narezkina A, Criado JR, Wills DN, Xia Y, Moresco EM, Ehlers C, Knowlton KU, Patapoutian A, Beutler B. PMID: 22087007; PMCID: PMC3228463.
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    66. Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias. Circulation. 2011 Dec 13; 124(24):2690-701. Yajima T, Murofushi Y, Zhou H, Park S, Housman J, Zhong ZH, Nakamura M, Machida M, Hwang KK, Gu Y, Dalton ND, Yajima T, Yasukawa H, Peterson KL, Knowlton KU. PMID: 22082679; PMCID: PMC3253669.
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    67. The costamere bridges sarcomeres to the sarcolemma in striated muscle. Prog Pediatr Cardiol. 2011 May; 31(2):83-88. Peter AK, Cheng H, Ross RS, Knowlton KU, Chen J. PMID: 24039381; PMCID: PMC3770312.
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    68. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet. 2011 May 01; 20(9):1751-62. Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton KU, Sheikh F, Chen J. PMID: 21303826; PMCID: PMC3071671.
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    69. Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res. 2010 Aug 06; 107(3):348-56. Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans SM, Knowlton KU, Peterson KL, Chen J. PMID: 20538684; PMCID: PMC3684396.
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    70. Viral myocarditis: from the perspective of the virus. Circulation. 2009 May 19; 119(19):2615-24. Yajima T, Knowlton KU. PMID: 19451363.
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    71. Viral myocarditis: is infection of the heart required? J Am Coll Cardiol. 2009 Apr 07; 53(14):1227-8. Knowlton KU, Lim BK. PMID: 19341865.
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    72. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug; 118(8):2758-70. Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU. PMID: 18636119; PMCID: PMC2467382.
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    73. CVB infection and mechanisms of viral cardiomyopathy. Curr Top Microbiol Immunol. 2008; 323:315-35. Knowlton KU. PMID: 18357777.
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    74. Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H69-76. Wang YX, da Cunha V, Vincelette J, White K, Velichko S, Xu Y, Gross C, Fitch RM, Halks-Miller M, Larsen BR, Yajima T, Knowlton KU, Vergona R, Sullivan ME, Croze E. PMID: 17434974.
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    75. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation. 2007 Jan 02; 115(1):94-102. Xiong D, Yajima T, Lim BK, Stenbit A, Dublin A, Dalton ND, Summers-Torres D, Molkentin JD, Duplain H, Wessely R, Chen J, Knowlton KU. PMID: 17190866.
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    76. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. PMID: 17101849.
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    77. alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation. 2006 Sep 05; 114(10):1046-55. Sheikh F, Chen Y, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard JC, Chen J. PMID: 16923756.
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    78. Treatment of coxsackievirus-B3-infected BALB/c mice with the soluble coxsackie adenovirus receptor CAR4/7 aggravates cardiac injury. J Mol Med (Berl). 2006 Oct; 84(10):842-51. Dörner A, Grunert HP, Lindig V, Chandrasekharan K, Fechner H, Knowlton KU, Isik A, Pauschinger M, Zeichhardt H, Schultheiss HP. PMID: 16924471.
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    79. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science. 2006 Jul 07; 313(5783):94-7. Trifilo MJ, Yajima T, Gu Y, Dalton N, Peterson KL, Race RE, Meade-White K, Portis JL, Masliah E, Knowlton KU, Chesebro B, Oldstone MB. PMID: 16825571; PMCID: PMC1820586.
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    80. Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol. 2006 Jun 19; 173(6):905-16. Bang ML, Li X, Littlefield R, Bremner S, Thor A, Knowlton KU, Lieber RL, Chen J. PMID: 16769824; PMCID: PMC2063916.
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    81. Unsolved medical issues and new targets for further research in viral myocarditis and dilated cardiomyopathy. Ernst Schering Res Found Workshop. 2006; (55):19-35. Knowlton KU. PMID: 16329655.
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    82. Long-term cardiac gene expression using a coxsackieviral vector. J Mol Cell Cardiol. 2005 May; 38(5):745-51. Lim BK, Shin JO, Lee SC, Kim DK, Choi DJ, Choe SC, Knowlton KU, Jeon ES. PMID: 15850568.
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    83. Highlights of the year in JACC 2004. J Am Coll Cardiol. 2005 Jan 04; 45(1):137-53. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Narula J, Sahn D, Tsimikas S. PMID: 15629388.
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    84. Interleukin-10: biomarker or pathologic cytokine in fulminant myocarditis? J Am Coll Cardiol. 2004 Sep 15; 44(6):1298-300. Knowlton KU, Yajima T. PMID: 15364335.
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    85. Chronic thromboembolic pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):453-66, vii. Auger WR, Kerr KM, Kim NH, Ben-Yehuda O, Knowlton KU, Fedullo PF. PMID: 15302364.
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    86. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. J Biol Chem. 2004 Apr 30; 279(18):18497-503. Dörner A, Xiong D, Couch K, Yajima T, Knowlton KU. PMID: 14978041.
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    87. Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Circulation. 2004 Jan 06; 109(1):18-22. Kim NH, Fesler P, Channick RN, Knowlton KU, Ben-Yehuda O, Lee SH, Naeije R, Rubin LJ. PMID: 14699009.
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    88. Highlights of the year in JACC 2003. J Am Coll Cardiol. 2003 Dec 17; 42(12):2156-66. DeMaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Tsimikas S. PMID: 15560019.
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    89. Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside. Med Microbiol Immunol. 2004 May; 193(2-3):121-6. Badorff C, Knowlton KU. PMID: 12920582.
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    90. Electrocardiographic manifestations: wide complex tachycardia due to accessory pathway. J Emerg Med. 2003 Apr; 24(3):295-301. Nelson JA, Knowlton KU, Harrigan R, Pollack ML, Chan TC. PMID: 12676301.
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    91. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. PMID: 12588885; PMCID: PMC151924.
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    92. Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by Coxsackievirus 2A protease. J Biol Chem. 2003 Feb 14; 278(7):4449-57. Zhao X, Lamphear BJ, Xiong D, Knowlton K, Rhoads RE. PMID: 12475969.
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    93. Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. Nat Med. 2002 Aug; 8(8):872-7. Xiong D, Lee GH, Badorff C, Dorner A, Lee S, Wolf P, Knowlton KU. PMID: 12118246.
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    94. Apoptosis and oncosis in the early progression of left ventricular dysfunction in the cardiomyopathic hamster. Basic Res Cardiol. 2002 Jan; 97(1):65-75. Ryoke T, Gu Y, Ikeda Y, Martone ME, Oh SS, Jeon ES, Knowlton KU, Ross J. PMID: 12004790.
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    95. Urban history, urban health. Am J Public Health. 2001 Dec; 91(12):1944-6. Knowlton K. PMID: 11726370; PMCID: PMC1446909.
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    96. Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling: implications for mortality and early viral replication. Circulation. 2001 Feb 06; 103(5):756-61. Wessely R, Klingel K, Knowlton KU, Kandolf R. PMID: 11156890.
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    97. The immune response following myocardial infarction: a role for T-cell-mediated myocyte damage. J Mol Cell Cardiol. 2000 Dec; 32(12):2107-10. Knowlton KU. PMID: 11112986.
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    98. Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: A protective mechanism against enteroviral cardiomyopathy. Circulation. 2000 Oct 31; 102(18):2276-81. Badorff C, Fichtlscherer B, Rhoads RE, Zeiher AM, Muelsch A, Dimmeler S, Knowlton KU. PMID: 11056105.
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    99. Dissociation of sarcoglycans and the dystrophin carboxyl terminus from the sarcolemma in enteroviral cardiomyopathy. Circ Res. 2000 Sep 15; 87(6):489-95. Lee GH, Badorff C, Knowlton KU. PMID: 10988241.
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    100. Enteroviral cardiomyopathy: bad news for the dystrophin-glycoprotein complex. Herz. 2000 May; 25(3):227-32. Badorff C, Lee GH, Knowlton KU. PMID: 10904843.
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    101. Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue. J Biol Chem. 2000 Apr 14; 275(15):11191-7. Badorff C, Berkely N, Mehrotra S, Talhouk JW, Rhoads RE, Knowlton KU. PMID: 10753926.
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    102. Inflammatory pathways and cardiac repair: the affliction of infarction. Nat Med. 1999 Oct; 5(10):1122-3. Knowlton KU, Chien KR. PMID: 10502807.
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    103. The immune system in viral myocarditis: maintaining the balance. Circ Res. 1999 Sep 17; 85(6):559-61. Knowlton KU, Badorff C. PMID: 10488059.
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    104. Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat Med. 1999 Mar; 5(3):320-6. Badorff C, Lee GH, Lamphear BJ, Martone ME, Campbell KP, Rhoads RE, Knowlton KU. PMID: 10086389.
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    105. Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? J Virol. 1999 Jan; 73(1):709-17. Kerekatte V, Keiper BD, Badorff C, Cai A, Knowlton KU, Rhoads RE. PMID: 9847377; PMCID: PMC103878.
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    106. Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy. J Clin Invest. 1998 Oct 01; 102(7):1444-53. Wessely R, Klingel K, Santana LF, Dalton N, Hongo M, Jonathan Lederer W, Kandolf R, Knowlton KU. PMID: 9769337; PMCID: PMC508992.
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    107. Low-level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes. Circulation. 1998 Aug 04; 98(5):450-7. Wessely R, Henke A, Zell R, Kandolf R, Knowlton KU. PMID: 9714096.
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    108. NF-kappaB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout mice. J Virol. 1998 Jul; 72(7):5654-60. Schwarz EM, Badorff C, Hiura TS, Wessely R, Badorff A, Verma IM, Knowlton KU. PMID: 9621024; PMCID: PMC110231.
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    109. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem. 1997 Feb 28; 272(9):5783-91. Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR. PMID: 9038192.
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    110. Alpha 1-adrenergic stimulation inhibits 3,5,3'-triiodothyronine-induced expression of the rat heart sarcoplasmic reticulum Ca2+ adenosine triphosphatase gene. Endocrinology. 1997 Jan; 138(1):114-20. Wu PS, Moriscot AS, Knowlton KU, Hilal-Dandan R, He H, Dillmann WH. PMID: 8977393.
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    111. A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3. J Virol. 1996 Nov; 70(11):7811-8. Knowlton KU, Jeon ES, Berkley N, Wessely R, Huber S. PMID: 8892902; PMCID: PMC190851.
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    112. Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. J Clin Invest. 1995 Sep; 96(3):1311-8. Knowlton KU, Rockman HA, Itani M, Vovan A, Seidman CE, Chien KR. PMID: 7657806; PMCID: PMC185753.
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    113. Regulated expression of a contractile protein gene correlates with recovery of contractile function after reversible metabolic inhibition in cultured myocytes. J Mol Cell Cardiol. 1995 Jan; 27(1):551-61. Barry WH, Hamilton CA, Knowlton KU. PMID: 7760376.
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    114. Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. J Biol Chem. 1994 May 06; 269(18):13490-6. LaMorte VJ, Thorburn J, Absher D, Spiegel A, Brown JH, Chien KR, Feramisco JR, Knowlton KU. PMID: 8175782.
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    115. The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 1993 Jul 25; 268(21):15374-80. Knowlton KU, Michel MC, Itani M, Shubeita HE, Ishihara K, Brown JH, Chien KR. PMID: 8393439.
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    116. Transcriptional regulation during cardiac growth and development. Annu Rev Physiol. 1993; 55:77-95. Chien KR, Zhu H, Knowlton KU, Miller-Hance W, van-Bilsen M, O'Brien TX, Evans SM. PMID: 8466192.
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    117. Peripartum vascular collapse Dissection of a genetic disease. Trends Cardiovasc Med. 1992 Jul-Aug; 2(4):125-8. Rockman HA, Knowlton KU. PMID: 21239257.
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    119. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J. 1991 Dec; 5(15):3037-46. Chien KR, Knowlton KU, Zhu H, Chien S. PMID: 1835945.
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    120. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8277-81. Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, Ross J, Chien KR. PMID: 1832775; PMCID: PMC52490.
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    121. Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. J Biol Chem. 1991 Apr 25; 266(12):7759-68. Knowlton KU, Baracchini E, Ross RS, Harris AN, Henderson SA, Evans SM, Glembotski CC, Chien KR. PMID: 1850419.
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    122. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 1990 Nov 25; 265(33):20555-62. Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotski CC, Brown JH, Chien KR. PMID: 2173712.
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    123. Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. J Clin Invest. 1990 Feb; 85(2):462-7. Maisel AS, Knowlton KU, Fowler P, Rearden A, Ziegler MG, Motulsky HJ, Insel PA, Michel MC. PMID: 2153706; PMCID: PMC296446.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    124. Cardiovascular molecular biology. Introduction to the series. Circulation. 1989 Aug; 80(2):219-33. Chien KR, Knowlton KU. PMID: 2502325.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    125. Catheter-directed neodymium:YAG laser injury of the left ventricle for arrhythmia ablation: dosimetry and hemodynamic, hematologic, and electrophysiologic effects. Lasers Surg Med. 1989; 9(5):446-53. Vincent GM, Fox J, Knowlton K, Dixon JA. PMID: 2811567.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    126. The effect of adrenal stimulation with adrenocorticotrophic hormone on the excretion of dehydroisoandrosterone in man. Endocrinology. 1951 May; 48(5):489-505. LANDAU RL, KNOWLTON K, LUGIBIHL K, KENYON AT. PMID: 14840409.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    127. The determination of urinary dehydroisoandrosterone in normal men and women and in adrenal disease. Endocrinology. 1951 May; 48(5):506-17. LANDAU RL, KNOWLTON K, LUGIBIHL K, MUNSON PL. PMID: 14840410.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    128. The significance of urinary dehydroisoandrosterone. J Clin Invest. 1950 Jun; 29(6):829-30. LANDAU RL, KNOWLTON K, LUGIBIHL K. PMID: 15436777.
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    129. The anabolic effects of chorionic gonadotropin in normal young men. J Clin Invest. 1950 May; 29(5):619-29. LANDAU RL, KNOWLTON K, LUGIBIHL K, BRANDT M, KENYON AT. PMID: 15415466; PMCID: PMC436099.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    130. The metabolic effects of chorionic gonadotrophins in young men. J Clin Invest. 1948 Jul; 27(4):545. LANDAU RL, KNOWLTON K. PMID: 18935175.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    131. STUDIES ON EXPERIMENTAL AND CLINICAL HYPOCHLOREMIA IN MAN. J Clin Invest. 1943 Jan; 22(1):95-102. Kirsner JB, Palmer WL, Knowlton K. PMID: 16694984; PMCID: PMC435212.
      View in: PubMed   Mentions: 1     Fields:    
    132. ACID-BASE BALANCE, RENAL FUNCTION, AND GASTRIC SECRETION DURING HYPOCHLOREMIA IN THE DOG. J Clin Invest. 1941 May; 20(3):303-12. Kirsner JB, Knowlton K. PMID: 16694836; PMCID: PMC435060.
      View in: PubMed   Mentions: 1     Fields:    
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