Kirk Knowlton

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Role of mTOR, a Component of the Akt Pathway, in Regulating Cardiac Function
    NIH R01HL078797Dec 1, 2004 - Nov 30, 2015
    Role: Principal Investigator
    Dystrophin-glycoprotein complex in viral cardiomyopathy
    NIH R01HL066424Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    Cardiac SOCS Proteins: A Role in Enterovirus Infection
    NIH R01HL057365Dec 5, 1998 - Apr 30, 2009
    Role: Principal Investigator
    MOLECULAR PHYSIOLOGY OF HEART FAILURE
    NIH P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Co-Investigator
    REGULATION OF ANF GENE DURING VENTRICULAR HYPERTROPHY
    NIH K08HL002618Aug 1, 1991 - Jul 31, 1997
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    Training in Cardiovascular Physiology and Pharmacology
    NIH T32HL007444Jul 1, 1979 - Jun 30, 2028
    Role: Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH P01HL046345Jun 30, 2014
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Recurrent right atrial myxoma presenting as pulmonary hypertension and peripheral pulmonary artery aneurysms. Thorax. 2026 Sep 15; 81(10):1020-1021. Taylor JC, Knowlton KU, Wilson TC, Dodson MW. PMID: 41371767.
      View in: PubMed   Mentions:    Fields:    
    2. Targeted vitamin D supplementation and major adverse cardiovascular events after myocardial infarction: the TARGET-D trial. Eur Heart J. 2026 Sep 07. May HT, Le VT, Anderson JL, Iverson L, Bair TL, Knight S, Knowlton KU, Peterson BE, Muhlestein JB. PMID: 42702500.
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    3. Ischemic Risk in Patients with Zero Coronary Artery Calcium Undergoing Stress PET/CT Testing. J Clin Med. 2026 Aug 26; 15(17). Anderson JL, Iverson LK, Bride DL, Knight S, McCubrey RO, Le VT, Dakhakhni M, Mason SM, Knowlton KU. PMID: 42739609; PMCID: PMC13566188.
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    4. The genetic architecture of fibromyalgia across 2.5 million individuals. Nat Med. 2026 Aug; 32(8):3060-3070. Kerrebijn I, Bjornsdottir G, Arbabi K, Urpa L, Haapaniemi H, Thorleifsson G, Stefansdottir L, Frangakis S, Valliere J, Kunorozva L, Abner E, Ji C, Kangur M, Aagaard B, Bliddal H, Brunak S, Bruun MT, Didriksen M, Erikstrup C, Finer S, Geirsson AJ, Gudbjartsson DF, Hansen TF, van Heel D, Jonsdottir I, Knight S, Knowlton KU, Mikkelsen C, Nadauld LD, Olafsdottir TA, Ostrowski SR, Pedersen OBV, Saevarsdottir S, Skuladottir AT, Sørensen E, Stefansson H, Sulem P, Sveinsson OA, Thorlacius GE, Thorsteinsdottir U, Ullum H, Vikingsson A, Werge TM, Chronic Pain Genomics Consortium, FinnGen, DBDS Genomic Consortium, Estonian Biobank Research Team, Genes & Health Research Team, Saxena R, Stefansson K, Brummett CM, Glintborg B, Clauw DJ, Thorgeirsson TE, Williams FMK, Sinnott-Armstrong N, Ollila HM, Wainberg M. PMID: 42521817; PMCID: PMC13472937.
      View in: PubMed   Mentions:    Fields:    
    5. Concussion AF trial: Longitudinal assessment of brain injury biomarkers and cognitive decline in elderly patients with atrial fibrillation. Heart Rhythm. 2026 Jul 23. Bunch TJ, May HT, Muhlestein JB, Anderson JL, Le V, Woller SC, Cutler MJ, Mahajan R, Targueta GP, Gurol ME, Knowlton K. PMID: 42492825.
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    6. Resistant Hypertension Variants Link to Hyperaldosteronism and Potassium Levels. Hypertension. 2026 Sep; 83(9):e22301. Tragante V, Sulem P, Thorleifsson G, Frigge ML, Arthur JG, Asselbergs FW, Banasik K, Brunak S, Christensen AH, Crawford DC, Deaton AM, Erikstrup C, Ferkingstad E, Ghouse J, Gretarsdottir S, Halldorsson GH, Helgadottir A, Iversen KK, Jonsdottir I, Knowlton KU, Kristjansson RP, Larusdottir AE, Lund SH, Magnusson MI, Melsted P, Nyegaard M, Oddsson A, Olafsson I, Olesen MS, Ostrowski SR, Palsson R, Pedersen OB, Sigurdardottir O, Stefansdottir L, Arnar DO, Sveinbjornsson G, Masson G, Sigurdsson EL, Thorgeirsson G, Ullum H, DBDS Genomic Consortium, Nadauld LD, Thorsteinsdottir U, Bundgaard H, Gudbjartsson DF, Stefansson K, Holm H. PMID: 42422974; PMCID: PMC13353209.
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    7. Low-Density Lipoprotein Cholesterol Lowering With Inclisiran Plus Usual Care in Recent Acute Coronary Syndrome: VICTORION-INCEPTION, a Randomized, Controlled, Open-Label Trial. J Am Heart Assoc. 2026 05 19; 15(10):e043655. Knowlton KU, Navar AM, Anderson JL, Brown AS, Muhlestein JB, Kleeman K, Sarwat S, Abbas CA, Ramirez MA, Grines CL, Abo-Auda WS, Desai NR. PMID: 42132192; PMCID: PMC13279551.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    8. CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics. Am Heart J. 2026 Sep; 299:107473. Anderson JL, May HT, Winslow T, Le VT, Iverson L, Bair TL, Knowlton KU, Muhlestein JB. PMID: 42106092.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    9. Observational and Mendelian randomization studies of plasma sclerostin levels do not provide evidence of cardiovascular adverse effects of sclerostin inhibition. Hum Mol Genet. 2026 Feb 09; 35(2). Thorolfsdottir RB, Sveinbjornsson G, Hjorleifsson Eldjarn G, Aegisdottir HM, Styrkarsdottir U, Gretarsdottir S, Steinthorsdottir V, Tragante V, Oddsson A, Stefansdottir L, Thorleifsson G, Einarsson G, Helgason H, Jonsdottir AB, Gudjonsson SA, Ferkingstad E, Brunak S, Brøns N, Bundgaard JS, Bruun MT, Erikstrup C, Aagaard B, Vesterager Pedersen OB, Sibilitz KL, Sørensen E, Træholt J, Ullum H, Zheng C, Knowlton KU, Nadauld LD, Ostrowski SR, Bundgaard H, Arnar DO, Jonsdottir I, Helgadottir A, Thorsteinsdottir U, Holm H, Sulem P, Gudbjartsson DF, Stefansson K, DBDS Genomic Consortium. PMID: 41324467.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Cardiomyocyte β-arrestins mediate inflammation and cGAS-STING activation in CVB3 viral myocarditis. Am J Physiol Heart Circ Physiol. 2026 02 01; 330(2):H499-H514. Lucero EY, Jiang H, D'Anniballe V, Pakharukova N, Galtes D, Bassford D, Jyothidasan A, Knowlton KU, Gunn MD, Lefkowitz RJ, Rockman HA. PMID: 41494659; PMCID: PMC12889003.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction. Nat Genet. 2026 01; 58(1):57-66. Small AM, Yang TY, Itoh S, Thériault S, Dufresne L, Kurosawa R, Komuro I, Matsuda K, Vy HMT, Farber-Eger EH, Shaffer LL, Boulier KM, Corey KM, Ramaker ME, Laporte F, Schott JJ, Le Scouarnec S, Singh SA, Sonawane AR, Smith HA, Rafaels N, Colorado Center for Personalized Medicine, Ghouse J, Raja AA, Ostrowski SR, Sørensen E, Mikkelsen C, Pedersen OB, Erikstrup C, Ullum H, DBDS Genomic Consortium, Sveinbjornsson G, Gudbjartsson DF, Abner E, Estonian Biobank Research Team, Lee J, Ganna A, Nowak-Göttl U, Finer S, Genes & Health Research Team, Schumacher J, Maj C, Al-Kassou B, Nickenig G, Trenkwalder T, Dreßen M, Krane M, Nöthen MM, Moksnes MR, Brumpton BM, Knight S, Knowlton KU, Nadauld L, Debiec R, Musameh MD, Braund PS, Nelson CP, Czuba T, Melander O, Selvaraj MS, Koyama S, Bhukar R, Ruan Y, Ljungberg J, Damrauer SM, Levin MG, Franke A, Berger K, Ruff CT, Melloni GEM, Kamanu FK, Ito K, Do R, Loos RJF, Schunkert H, Wells QS, Shah SH, Le Tourneau T, Messika-Zeitoun D, Gignoux C, Bundgaard H, Larsson SC, Michaëlsson K, Holm H, Helgadottir A, Esko T, van Heel DA, Mathieu P, Samani NJ, Smith JG, Söderberg S, Rader DJ, Marston NA, Sabatine MS, Pasaniuc B, Cho K, Wilson PWF, O'Donnell CJ, Stefansson K, Bossé Y, Aikawa E, Engert JC, Peloso GM, Natarajan P, Thanassoulis G. PMID: 41419686; PMCID: PMC12807872.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Examining covariate-specific treatment effects in individual participant data meta-analysis: Framing aggregation bias in terms of trial-level confounding and funnel plots. Res Synth Methods. 2026 Jan; 17(1):194-209. Siegel LK, Koopmeiners JS, Hartmann-Boyce J, Godolphin PJ, Babiker AG, Touloumi G, Knowlton KU, Riley RD. PMID: 41626891; PMCID: PMC12823212.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. The genetic architecture of fibromyalgia across 2.5 million individuals. medRxiv. 2025 Sep 19. Kerrebijn I, Bjornsdottir G, Arbabi K, Urpa L, Haapaniemi H, Thorleifsson G, Stefansdottir L, Frangakis S, Valliere J, Kunorozva L, Abner E, Ji C, Aagaard B, Bliddal H, Brunak S, Bruun MT, Didriksen M, Erikstrup C, Geirsson AJ, Gudbjartsson DF, Hansen TF, Jonsdottir I, Knight S, Knowlton KU, Mikkelsen C, Nadauld LD, Olafsdottir TA, Ostrowski SR, Pedersen OB, Saevarsdottir S, Skuladottir AT, Sørensen E, Stefansson H, Sulem P, Sveinsson OA, Thorlacius GE, Thorsteinsdottir U, Ullum H, Vikingsson A, Werge TM, Chronic Pain Genomics Consortium, FinnGen, DBDS Genomic Consortium, Estonian Biobank Research Team, Genes & Health Research Team, Saxena R, Stefansson K, Brummett CM, Glintborg B, Clauw DJ, Thorgeirsson TE, Williams FM, Sinnott-Armstrong N, Ollila HM, Wainberg M. PMID: 41001472; PMCID: PMC12458511.
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    14. Does Sex or Age Impact the Prognostic Value of a Zero Coronary Artery Calcium Score? J Clin Med. 2025 Sep 04; 14(17). Anderson JL, Collingridge DS, Le VT, Iverson L, Muhlestein JB, Bair TL, Knight S, Mason SM, Knowlton KU. PMID: 40944018; PMCID: PMC12429088.
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    15. Association of study visit interval length with follow-up completeness and adherence to assigned study drug dose: A randomized comparison of participants in the ADAPTABLE trial. Contemp Clin Trials. 2025 09; 156:108030. Narcisse DI, Whittle J, Rhodes GM, Stebbins AL, Wruck LM, Mulder H, Kripalani S, Muñoz D, Effron MB, Gupta K, Handberg EM, Girotra S, Hess R, Benziger CP, Farrehi P, VanWormer JJ, Knowlton KU, Polonsky TS, Bradley SM, Robertson HR, Hammill BG, Rothman RL, Harrington RA, Jones WS, Hernandez AF. PMID: 40716702.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Passive immunotherapy for adults hospitalized with COVID-19: An individual participant data meta-analysis of six randomized controlled trials. PLoS Med. 2025 Jul; 22(7):e1004616. Knowlton KU, Siegel LK, Barkauskas CE, Bhagani S, Dharan NJ, Gardner EM, Gottlieb RL, Helleberg M, Highbarger HC, Holland TL, Heerfordt CK, Lazarte S, Leither LM, Lutaakome J, Ardelt M, Mylonakis E, Ong SWX, Overcash JS, Taha H, Tien PC, Trautner BW, Vallee D, Weintrob AC, Touloumi G, Babiker AG, STRIVE ACTIV-3/TICO Study Group. PMID: 40623115; PMCID: PMC12282900.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Genome-wide meta-analysis identifies nine loci associated with higher risk of hepatocellular carcinoma development. JHEP Rep. 2025 Sep; 7(9):101485. Ghouse J, Gellert-Kristensen H, O'Rourke CJ, Seidelin AS, Thorleifsson G, Sveinbjörnsson G, Tragante V, Konkwo C, Brancale J, Vilarinho S, Eyrich TM, Ahlberg G, Bundgaard JS, Rand SA, Lundegaard PR, Sørensen E, Mikkelsen C, Træholt J, Erikstrup C, Dinh KM, Bruun MT, Jensen BA, Bay JT, Brunak S, Banasik K, Ullum H, DBDS Genomic Consortium, Estonian Biobank Research Team, Laisk T, Mägi R, Nadauld LD, Knowlton KU, Knight S, Gluud LL, Vistisen K, Björnsson ES, Ulfarsson MO, Sulem P, Holm H, Pedersen OB, Ostrowski SR, Gudbjartsson DF, Rafnar T, Stefansson K, Lassen U, Pommergaard HC, Hillingsø JG, Andersen JB, Bundgaard H, Stender S. PMID: 40823170; PMCID: PMC12355075.
      View in: PubMed   Mentions: 1  
    18. Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy. Am J Hum Genet. 2025 07 03; 112(7):1681-1698. Nicastro M, Vermeer AMC, Postema PG, Tadros R, Bowling FZ, Aegisdottir HM, Tragante V, Mach L, Postma AV, Lodder EM, van Duijvenboden K, Zwart R, Beekman L, Wu L, Jurgens SJ, van der Zwaag PA, Alders M, Allouba M, Aguib Y, Santome JL, de Una D, Monserrat L, Miranda AMA, Kanemaru K, Cranley J, van Zeggeren IE, Aronica EMA, Ripolone M, Zanotti S, Sveinbjornsson G, Ivarsdottir EV, Hólm H, Guðbjartsson DF, Skúladóttir ÁT, Stefánsson K, Nadauld L, Knowlton KU, Ostrowski SR, Sørensen E, Vesterager Pedersen OB, Ghouse J, Rand SA, Bundgaard H, Ullum H, Erikstrup C, Aagaard B, Bruun MT, Christiansen M, Jensen HK, Carere DA, Cummings CT, Fishler K, Tørring PM, Brusgaard K, Juul TM, Saaby L, Winkel BG, Mogensen J, Fortunato F, Comi GP, Ronchi D, van Tintelen JP, Noseda M, Airola MV, Christiaans I, Wilde AAM, Wilders R, Clur SA, Verkerk AO, Bezzina CR, Lahrouchi N. PMID: 40409267; PMCID: PMC12256823.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    19. Missense variants in FRS3 affect body mass index in populations of diverse ancestries. Nat Commun. 2025 Mar 25; 16(1):2694. Jonsdottir AB, Sveinbjornsson G, Thorolfsdottir RB, Tamlander M, Tragante V, Olafsdottir T, Rognvaldsson S, Sigurdsson A, Eggertsson HP, Aegisdottir HM, Arnar DO, Banasik K, Beyter D, Bjarnason RG, Bjornsdottir G, Brunak S, Topholm Bruun M, Dowsett J, Einarsson E, Einarsson G, Erikstrup C, Fridriksdottir R, Ghouse J, Gretarsdottir S, Halldorsson GH, Hansen T, Helgadottir A, Holm PC, Ivarsdottir EV, Iversen KK, Jensen BA, Jonsdottir I, Knight S, Knowlton KU, Kristmundsdottir S, Larusdottir AE, Magnusson OT, Masson G, Melsted P, Mikkelsen C, Moore KHS, Oddsson A, Olason PI, Palsson F, Pedersen OB, Schwinn M, Sigurdsson EL, Skaftason A, Stefansdottir L, Stefansson H, Steingrimsdottir T, Sturluson A, Styrkarsdottir U, Sørensen E, Teitsdottir UD, Thorgeirsson TE, Thorisson GA, Thorsteinsdottir U, Ulfarsson MO, Ullum H, Vikingsson A, Walters GB, DBDS Genomic Consortium, Nadauld LD, Bundgaard H, Ostrowski SR, Helgason A, Halldorsson BV, Norddahl GL, Ripatti S, Gudbjartsson DF, Thorleifsson G, Steinthorsdottir V, Holm H, Sulem P, Stefansson K. PMID: 40133257; PMCID: PMC11937519.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Atrial Fibrillation as a Predictor of Age-Related Macular Degeneration. J Cardiovasc Electrophysiol. 2025 05; 36(5):990-995. Bunch KT, May HT, Knowlton KU, Bair TL, Muhlestein JB, Anderson JL, Ranjan R, Steinberg BA, Bunch TJ. PMID: 40065587.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial. Front Endocrinol (Lausanne). 2024; 15:1401780. Horne BD, Anderson JL, May HT, Bair TL, Le VT, Iverson L, Knowlton KU, Muhlestein JB. PMID: 39991046; PMCID: PMC11842881.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Genome-Wide Association Study of Accessory Atrioventricular Pathways. JAMA Cardiol. 2024 11 01; 9(11):1053-1058. Aegisdottir HM, Andreasen L, Thorolfsdottir RB, Sveinbjornsson G, Jonsdottir AB, Stefansdottir L, Thorleifsson G, Sigurdsson A, Halldorsson GH, Barc J, Simonet F, Tragante V, Oddsson A, Ferkingstad E, Svendsen JH, Ghouse J, Ahlberg G, Paludan-Müller C, Hadji-Turdeghal K, Bustamante M, Ulfarsson MO, Helgadottir A, Gretarsdottir S, Saevarsdottir S, Jonsdottir I, Erikstrup C, Ullum H, Sørensen E, Brunak S, Jøns C, Zheng C, Bezzina CR, Knowlton KU, Nadauld LD, Sulem P, Ostrowski SR, Pedersen OB, Arnar DO, Gudbjartsson DF, Olesen MS, Bundgaard H, Holm H, Stefansson K, DBDS consortium. PMID: 39230897; PMCID: PMC11375522.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Insulin resistance reduction, intermittent fasting, and human growth hormone: secondary analysis of a randomized trial. NPJ Metab Health Dis. 2024 Oct 03; 2(1):26. Horne BD, Anderson JL, May HT, Bair TL, Le VT, Iverson L, Knowlton KU, Muhlestein JB. PMID: 40604163; PMCID: PMC12118664.
      View in: PubMed   Mentions: 1  
    24. Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density. J Clin Endocrinol Metab. 2024 07 12; 109(8):e1608-e1615. Styrkarsdottir U, Tragante V, Stefansdottir L, Thorleifsson G, Oddsson A, Sørensen E, Erikstrup C, Schwarz P, Jørgensen HL, Lauritzen JB, Brunak S, Knowlton KU, Nadauld LD, Ullum H, Pedersen OBV, Ostrowski SR, Holm H, Gudbjartsson DF, Sulem P, Stefansson K. PMID: 38118020; PMCID: PMC11244190.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease. Nat Commun. 2024 07 09; 15(1):5748. Saevarsdottir S, Bjarnadottir K, Markusson T, Berglund J, Olafsdottir TA, Halldorsson GH, Rutsdottir G, Gunnarsdottir K, Arnthorsson AO, Lund SH, Stefansdottir L, Gudmundsson J, Johannesson AJ, Sturluson A, Oddsson A, Halldorsson B, Ludviksson BR, Ferkingstad E, Ivarsdottir EV, Sveinbjornsson G, Grondal G, Masson G, Eldjarn GH, Thorisson GA, Kristjansdottir K, Knowlton KU, Moore KHS, Gudjonsson SA, Rognvaldsson S, Knight S, Nadauld LD, Holm H, Magnusson OT, Sulem P, Gudbjartsson DF, Rafnar T, Thorleifsson G, Melsted P, Norddahl GL, Jonsdottir I, Stefansson K. PMID: 38982041; PMCID: PMC11233504.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Periodic Fasting and Acute Cardiac Events in Patients Evaluated for COVID-19: An Observational Prospective Cohort Study. Nutrients. 2024 Jun 28; 16(13). Horne BD, Anderson JL, Haddad F, May HT, Le VT, Knight S, Bair TL, Knowlton KU. PMID: 38999823; PMCID: PMC11243697.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    27. Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease. N Engl J Med. 2024 06 20; 390(23):2217-2219. Stefansson H, Walters GB, Sveinbjornsson G, Tragante V, Einarsson G, Helgason H, Sigurðsson A, Beyter D, Snaebjarnarson AS, Ivarsdottir EV, Thorleifsson G, Halldorsson BV, Norddahl G, Styrkarsdottir U, Sturluson A, Holm H, Helgason A, Moore K, Eggertsson HP, Oddsson AH, Jonsdottir GA, Gunnarsson AF, Bjornsdottir G, Gisladottir RS, Thorgeirsson TE, Skuladottir A, Gudbjartsson DF, Sulem P, Jonsson P, Thordardottir S, Snaedal J, Eyjolfsdottir H, Creese B, Ballard C, Corbett A, Vasconcelos Da Silva M, Aarsland D, Andreassen OA, DemGen Study Group, Selbæk G, Djurovic S, Stordal E, Fladby T, Haavik J, Igland J, Giil LM, Eriksson S, Hallmans G, Lövheim H, Lopatko Lindman K, Trupp M, Forsgren L, Werge T, Banasik K, Brunak S, Ullum H, Frikke-Schmidt R, Ostrowski SR, DBDS Genomic Consortium, Didriksen M, Sørensen E, Simonsen AH, Nielsen JE, Waldemar G, Pedersen OB, Erikstrup C, Knowlton KU, Nadauld LD, Stefansson K, DemGen Study Group and DBDS Genomic Consortium. PMID: 38899702.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. Framework of the strengths and challenges of clinically integrated trials: An expert panel report. Am Heart J. 2024 09; 275:62-73. Peters AE, Jones WS, Anderson B, Bramante CT, Broedl U, Hornik CP, Kehoe L, Knowlton KU, Krofah E, Landray M, Locke T, Patel MR, Psotka M, Rockhold FW, Roessig L, Rothman RL, Schofield L, Stockbridge N, Trontell A, Curtis LH, Tenaerts P, Hernandez AF. PMID: 38795793; PMCID: PMC11330722.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Contemporary Predictors of Major Adverse Cardiovascular Events Following Percutaneous Coronary Intervention: A Nationally Representative US Sample. J Clin Med. 2024 May 11; 13(10). Horne BD, Atreja N, Venditto J, Wilson T, Muhlestein JB, St Clair JR, Knowlton KU, Khan ND, Bhalla N, Anderson JL. PMID: 38792388; PMCID: PMC11121929.
      View in: PubMed   Mentions: 2  
    30. Coronary Calcium Is Elevated in Patients with Myocardial Infarction without Standard Modifiable Risk Factors. J Clin Med. 2024 Apr 27; 13(9). Anderson JL, Knight S, Dong L, May HT, Le VT, Bair TL, Knowlton KU. PMID: 38731098; PMCID: PMC11084599.
      View in: PubMed   Mentions:
    31. GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis. Commun Biol. 2024 04 26; 7(1):504. Skuladottir AT, Stefansdottir L, Halldorsson GH, Stefansson OA, Bjornsdottir A, Jonsson P, Palmadottir V, Thorgeirsson TE, Walters GB, Gisladottir RS, Bjornsdottir G, Jonsdottir GA, Sulem P, Gudbjartsson DF, Knowlton KU, Jones DA, Ottas A, Estonian Biobank, Pedersen OB, Didriksen M, Brunak S, Banasik K, Hansen TF, Erikstrup C, DBDS Genomic Consortium, Haavik J, Andreassen OA, Rye D, Igland J, Ostrowski SR, Milani LA, Nadauld LD, Stefansson H, Stefansson K. PMID: 38671141; PMCID: PMC11053069.
      View in: PubMed   Mentions: 6  Translation:Humans
    32. Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis. Nat Genet. 2024 May; 56(5):827-837. Ghouse J, Sveinbjörnsson G, Vujkovic M, Seidelin AS, Gellert-Kristensen H, Ahlberg G, Tragante V, Rand SA, Brancale J, Vilarinho S, Lundegaard PR, Sørensen E, Erikstrup C, Bruun MT, Jensen BA, Brunak S, Banasik K, Ullum H, DBDS Genomic Consortium, Verweij N, Lotta L, Baras A, Regeneron Genetics Center, Mirshahi T, Carey DJ, Geisinger-Regeneron DiscovEHR Collaboration, VA Million Veteran Program, Kaplan DE, Lynch J, Morgan T, Schwantes-An TH, Dochtermann DR, Pyarajan S, Tsao PS, Estonian Biobank Research Team, Laisk T, Mägi R, Kozlitina J, Tybjærg-Hansen A, Jones D, Knowlton KU, Nadauld L, Ferkingstad E, Björnsson ES, Ulfarsson MO, Sturluson Á, Sulem P, Pedersen OB, Ostrowski SR, Gudbjartsson DF, Stefansson K, Olesen MS, Chang KM, Holm H, Bundgaard H, Stender S. PMID: 38632349; PMCID: PMC11096111.
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    33. Association of Short-Term Increases in Ambient Fine Particulate Matter With Hospitalization for Asthma or COPD During Wildfire Season and Other Time Periods. CHEST Pulm. 2024 Jun; 2(2). Horne BD, Johnson MM, Blagev DP, Haddad F, Knowlton KU, Bride D, Bair TL, Joy EA, Nadeau KC. PMID: 38993972; PMCID: PMC11238943.
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    34. Absence of Pericarditis Recurrence in Rilonacept-Treated Patients With COVID-19 and SARS-CoV-2 Vaccination: Results From the RHAPSODY Long-term Extension. CJC Open. 2024 Jun; 6(6):805-810. Brucato A, Trotta L, Arad M, Cremer PC, Insalaco A, Klutstein M, LeWinter M, Lin D, Luis SA, Wasserstrum Y, Clair J, Wang S, Klein AL, Imazio M, Paolini JF, RHAPSODY Investigators. PMID: 39022168; PMCID: PMC11250856.
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    37. Impact of Active vs Passive Statin Selection for Primary Prevention: The CorCal Vanguard Trial. JACC Adv. 2023 Dec; 2(10):100676. Anderson JL, Knowlton KU, May HT, Le VT, Lappe' DL, Cripps ST, Schwab LH, Winslow T, Bair TL, Muhlestein JB. PMID: 38938499; PMCID: PMC11198348.
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    38. Impact of Statin Therapy in Heart Failure Patients: Results of a Large Real-World Experience. JACC Adv. 2023 Jun; 2(4):100385. Anderson JL, May HT, Le VT, Muhlestein JB, Horne BD, Bair TL, Knight S, Knowlton KU. PMID: 38938227; PMCID: PMC11198218.
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    39. Disruption in Blood Pressure Control With the COVID-19 Pandemic: The PCORnet Blood Pressure Control Laboratory. Mayo Clin Proc. 2023 05; 98(5):662-675. Chamberlain AM, Cooper-DeHoff RM, Fontil V, Nilles EK, Shaw KM, Smith M, Lin F, Vittinghoff E, Maeztu C, Todd JV, Carton T, O'Brien EC, Faulkner Modrow M, Wozniak G, Rakotz M, Sanchez E, Smith SM, Polonsky TS, Ahmad FS, Liu M, McClay JC, VanWormer JJ, Taylor BW, Chrischilles EA, Wu S, Viera AJ, Ford DE, Hwang W, Knowlton KU, Pletcher MJ. PMID: 37137641; PMCID: PMC9874044.
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    40. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. Eur Heart J. 2022 05 01; 43(17):1668-1680. Roselli C, Yu M, Nauffal V, Georges A, Yang Q, Love K, Weng LC, Delling FN, Maurya SR, Schrölkamp M, Tfelt-Hansen J, Hagège A, Jeunemaitre X, Debette S, Amouyel P, Guan W, Muehlschlegel JD, Body SC, Shah S, Samad Z, Kyryachenko S, Haynes C, Rienstra M, Le Tourneau T, Probst V, Roussel R, Wijdh-Den Hamer IJ, Siland JE, Knowlton KU, Jacques Schott J, Levine RA, Benjamin EJ, Vasan RS, Horne BD, Muhlestein JB, Benfari G, Enriquez-Sarano M, Natale A, Mohanty S, Trivedi C, Shoemaker MB, Yoneda ZT, Wells QS, Baker MT, Farber-Eger E, Michelena HI, Lundby A, Norris RA, Slaugenhaupt SA, Dina C, Lubitz SA, Bouatia-Naji N, Ellinor PT, Milan DJ. PMID: 35245370; PMCID: PMC9649914.
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    41. Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial. Ann Intern Med. 2022 02; 175(2):234-243. ACTIV-3/TICO Bamlanivimab Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Goodman AL, Chang W, Dewar RL, Gerry NP, Higgs ES, Highbarger H, Murray DD, Murray TA, Natarajan V, Paredes R, Parmar MKB, Phillips AN, Reilly C, Rupert AW, Sharma S, Shaw-Saliba K, Sherman BT, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Davey VJ, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD. PMID: 34928698; PMCID: PMC9334931.
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    42. Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease. N Engl J Med. 2021 05 27; 384(21):1981-1990. Jones WS, Mulder H, Wruck LM, Pencina MJ, Kripalani S, Muñoz D, Crenshaw DL, Effron MB, Re RN, Gupta K, Anderson RD, Pepine CJ, Handberg EM, Manning BR, Jain SK, Girotra S, Riley D, DeWalt DA, Whittle J, Goldberg YH, Roger VL, Hess R, Benziger CP, Farrehi P, Zhou L, Ford DE, Haynes K, VanWormer JJ, Knowlton KU, Kraschnewski JL, Polonsky TS, Fintel DJ, Ahmad FS, McClay JC, Campbell JR, Bell DS, Fonarow GC, Bradley SM, Paranjape A, Roe MT, Robertson HR, Curtis LH, Sharlow AG, Berdan LG, Hammill BG, Harris DF, Qualls LG, Marquis-Gravel G, Modrow MF, Marcus GM, Carton TW, Nauman E, Waitman LR, Kho AN, Shenkman EA, McTigue KM, Kaushal R, Masoudi FA, Antman EM, Davidson DR, Edgley K, Merritt JG, Brown LS, Zemon DN, McCormick TE, Alikhaani JD, Gregoire KC, Rothman RL, Harrington RA, Hernandez AF, ADAPTABLE Team. PMID: 33999548; PMCID: PMC9908069.
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    43. A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. N Engl J Med. 2021 03 11; 384(10):905-914. ACTIV-3/TICO LY-CoV555 Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Davey VJ, Goodman A, Higgs ES, Murray DD, Murray TA, Paredes R, Parmar MKB, Phillips AN, Reilly C, Sharma S, Dewar RL, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD. PMID: 33356051; PMCID: PMC7781100.
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    44. Evaluation of Routine Coronary Angiography Before Pulmonary Thromboendarterectomy. Ann Thorac Surg. 2021 05; 111(5):1703-1709. Pandey AK, Lee NS, Marsal J, Knowlton KU, McDivit AM, Blanchard DG, Pretorius V, Madani MM, Fedullo PF, Kerr KM, Kim NH, Fernandes TM, Poch DS, Auger WR, Daniels LB. PMID: 32896544.
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    45. Predictors of Statin Intolerance in Patients With a New Diagnosis of Atherosclerotic Cardiovascular Disease Within a Large Integrated Health Care Institution: The IMPRES Study. J Cardiovasc Pharmacol. 2020 05; 75(5):426-431. Bair TL, May HT, Knowlton KU, Anderson JL, Lappe DL, Muhlestein JB. PMID: 32079856.
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    46. Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function. Circ Res. 2020 07 03; 127(2):284-297. Zhang J, Vincent KP, Peter AK, Klos M, Cheng H, Huang SM, Towne JK, Ferng D, Gu Y, Dalton ND, Chan Y, Li R, Peterson KL, Chen J, McCulloch AD, Knowlton KU, Ross RS. PMID: 32345129; PMCID: PMC7571547.
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    47. Absence of Coronary Artery Calcium During Positron Emission Tomography Stress Testing in Patients Without Known Coronary Artery Disease Identifies Individuals With Very Low Risk of Cardiac Events. Circ Cardiovasc Imaging. 2020 01; 13(1):e009907. Le VT, Knight S, Min DB, McCubrey RO, Horne BD, Jensen KR, Meredith KG, Mason SM, Lappé DL, Anderson JL, Muhlestein JB, Knowlton KU. PMID: 31959008.
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    48. Free thyroxine within the normal reference range predicts risk of atrial fibrillation. J Cardiovasc Electrophysiol. 2020 01; 31(1):18-29. Anderson JL, Jacobs V, May HT, Bair TL, Benowitz BA, Lappe DL, Muhlestein JB, Knowlton KU, Bunch TJ. PMID: 31515856.
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    49. Comparison of Three Atherosclerotic Cardiovascular Disease Risk Scores With and Without Coronary Calcium for Predicting Revascularization and Major Adverse Coronary Events in Symptomatic Patients Undergoing Positron Emission Tomography-Stress Testing. Am J Cardiol. 2020 02 01; 125(3):341-348. Anderson JL, Le VT, Min DB, Biswas S, Minder CM, McCubrey RO, Knight S, Horne BD, Mason S, Lappe DL, Muhlestein JB, Knowlton KU. PMID: 31806210.
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    50. Value of Neutrophil to Lymphocyte Ratio and Its Trajectory in Patients Hospitalized With Acute Heart Failure and Preserved Ejection Fraction. Am J Cardiol. 2020 01 15; 125(2):229-235. Boralkar KA, Kobayashi Y, Amsallem M, Ataam JA, Moneghetti KJ, Cauwenberghs N, Horne BD, Knowlton KU, Maecker H, Kuznetsova T, Heidenreich PA, Haddad F. PMID: 31753313.
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    51. Circulating Levels of Biomarkers of Cerebral Injury in Patients with Atrial Fibrillation. Am J Cardiol. 2019 12 01; 124(11):1697-1700. Galenko O, Jacobs V, Knight S, Bride D, Cutler MJ, Muhlestein JB, Carlquist JL, Anderson JL, Knowlton KU, Jared Bunch T. PMID: 31575426.
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    52. Approaching Higher Dimension Imaging Data Using Cluster-Based Hierarchical Modeling in Patients with Heart Failure Preserved Ejection Fraction. Sci Rep. 2019 07 18; 9(1):10431. Kobayashi Y, Tremblay-Gravel M, Boralkar KA, Li X, Nishi T, Amsallem M, Moneghetti KJ, Bouajila S, Selej M, Ozen MO, Demirci U, Ashley E, Wheeler M, Knowlton KU, Kouznetsova T, Haddad F. PMID: 31320698; PMCID: PMC6639369.
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    53. Improving risk stratification in heart failure with preserved ejection fraction by combining two validated risk scores. Open Heart. 2019; 6(1):e000961. Boralkar KA, Kobayashi Y, Moneghetti KJ, Pargaonkar VS, Tuzovic M, Krishnan G, Wheeler MT, Banerjee D, Kuznetsova T, Horne BD, Knowlton KU, Heidenreich PA, Haddad F. PMID: 31217994; PMCID: PMC6546198.
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    54. Dilated Cardiomyopathy. Circulation. 2019 05 14; 139(20):2339-2341. Knowlton KU. PMID: 31082299.
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    55. Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture. Circulation. 2019 03 19; 139(12):1554-1556. Zhang Z, Mu Y, Zhang J, Zhou Y, Cattaneo P, Veevers J, Peter AK, Manso AM, Knowlton KU, Zhou X, Evans SM, Ross RS, Chen J. PMID: 30883226; PMCID: PMC6424132.
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    56. Safety and Efficacy of Periprocedural Heparin Plus a Short-Term Infusion of Tirofiban Versus Bivalirudin Monotherapy in Patients Who Underwent Percutaneous Coronary Intervention (from the Intermountain Heart Institute STAIR Observational Registry). Am J Cardiol. 2019 06 15; 123(12):1927-1934. Muhlestein JB, Hackett IS, May HT, Bair TL, Le VT, Anderson JL, Whisenant B, Knowlton KU, Lappé DL. PMID: 30981419.
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    57. The role of microRNAs in the development, regulation, and treatment of atrial fibrillation. J Interv Card Electrophysiol. 2019 Sep; 55(3):297-305. Galenko O, Jacobs V, Knight S, Taylor M, Cutler MJ, Muhlestein JB, Carlquist JL, Knowlton KU, Jared Bunch T. PMID: 30607665.
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    58. CHA2DS2-VASc scores and Intermountain Mortality Risk Scores for the joint risk stratification of dementia among patients with atrial fibrillation. Heart Rhythm. 2019 01; 16(1):3-9. Graves KG, May HT, Jacobs V, Knowlton KU, Muhlestein JB, Lappe DL, Anderson JL, Horne BD, Bunch TJ. PMID: 30611392.
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    59. Prediction of Long-Term Incidence of Chronic Cardiovascular and Cardiopulmonary Diseases in Primary Care Patients for Population Health Monitoring: The Intermountain Chronic Disease Model (ICHRON). Mayo Clin Proc. 2019 07; 94(7):1221-1230. May HT, Lappé DL, Knowlton KU, Muhlestein JB, Anderson JL, Horne BD. PMID: 30577973.
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    60. Improving CHA2DS2-VASc stratification of non-fatal stroke and mortality risk using the Intermountain Mortality Risk Score among patients with atrial fibrillation. Open Heart. 2018; 5(2):e000907. Graves KG, May HT, Knowlton KU, Muhlestein JB, Jacobs V, Lappé DL, Anderson JL, Horne BD, Bunch TJ. PMID: 30564375; PMCID: PMC6269639.
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    62. Extreme erythrocyte macrocytic and microcytic percentages are highly predictive of morbidity and mortality. JCI Insight. 2018 07 26; 3(14). Horne BD, Muhlestein JB, Bennett ST, Muhlestein JB, Jensen KR, Marshall D, Bair TL, May HT, Carlquist JF, Hegewald M, Knight S, Le VT, Bunch TJ, Lappé DL, Anderson JL, Knowlton KU. PMID: 30046011; PMCID: PMC6124438.
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    63. How Community-Based Health Systems Can Embrace Research in the Fee-for-Value Era. Qual Manag Health Care. 2018 Jul/Sep; 27(3):180-182. Knighton AJ, Grissom CK, Knowlton KU, Sean Esplin M, Graydon T, Srivastava R, Intermountain Healthcare Research Guidance Council. PMID: 29944632.
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    64. Implementation of a cardiac PET stress program: comparison of outcomes to the preceding SPECT era. JCI Insight. 2018 05 03; 3(9). Knight S, Min DB, Le VT, Meredith KG, Dhar R, Biswas S, Jensen KR, Mason SM, Ethington JD, Lappe DL, Muhlestein JB, Anderson JL, Knowlton KU. PMID: 29720565; PMCID: PMC6012503.
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    65. GlycA and hsCRP are independent and additive predictors of future cardiovascular events among patients undergoing angiography: The intermountain heart collaborative study. Am Heart J. 2018 08; 202:27-32. Muhlestein JB, May HT, Galenko O, Knowlton KU, Otvos JD, Connelly MA, Lappe DL, Anderson JL. PMID: 29803983.
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    66. Temporal changes in statin prescription and intensity at discharge and impact on outcomes in patients with newly diagnosed atherosclerotic cardiovascular disease-Real-world experience within a large integrated health care system: The IMPRES study. J Clin Lipidol. 2018 Jul - Aug; 12(4):1008-1018.e1. Anderson JL, Knowlton KU, May HT, Bair TL, Armstrong SO, Lappé DL, Muhlestein JB. PMID: 29703626.
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    67. Real world MRI experience with nonconditional and conditional cardiac rhythm devices after MagnaSafe. J Cardiovasc Electrophysiol. 2017 Dec; 28(12):1468-1474. Mason S, Osborn JS, Dhar R, Tonkin A, Ethington JD, Le V, Benuzillo J, Lappe DL, Knowlton KU, Bunch TJ, Anderson JL. PMID: 28960745.
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    69. Myocarditis: An Intersection Between Genetic and Acquired Causes of Human Cardiomyopathy. J Am Coll Cardiol. 2017 04 04; 69(13):1666-1668. Knowlton KU. PMID: 28359510.
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    81. Viral myocarditis: from the perspective of the virus. Circulation. 2009 May 19; 119(19):2615-24. Yajima T, Knowlton KU. PMID: 19451363.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    82. Viral myocarditis: is infection of the heart required? J Am Coll Cardiol. 2009 Apr 07; 53(14):1227-8. Knowlton KU, Lim BK. PMID: 19341865.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    83. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug; 118(8):2758-70. Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU. PMID: 18636119; PMCID: PMC2467382.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    84. CVB infection and mechanisms of viral cardiomyopathy. Curr Top Microbiol Immunol. 2008; 323:315-35. Knowlton KU. PMID: 18357777.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    85. Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H69-76. Wang YX, da Cunha V, Vincelette J, White K, Velichko S, Xu Y, Gross C, Fitch RM, Halks-Miller M, Larsen BR, Yajima T, Knowlton KU, Vergona R, Sullivan ME, Croze E. PMID: 17434974.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    86. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation. 2007 Jan 02; 115(1):94-102. Xiong D, Yajima T, Lim BK, Stenbit A, Dublin A, Dalton ND, Summers-Torres D, Molkentin JD, Duplain H, Wessely R, Chen J, Knowlton KU. PMID: 17190866.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    87. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. PMID: 17101849.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    88. alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation. 2006 Sep 05; 114(10):1046-55. Sheikh F, Chen Y, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard JC, Chen J. PMID: 16923756.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    89. Treatment of coxsackievirus-B3-infected BALB/c mice with the soluble coxsackie adenovirus receptor CAR4/7 aggravates cardiac injury. J Mol Med (Berl). 2006 Oct; 84(10):842-51. Dörner A, Grunert HP, Lindig V, Chandrasekharan K, Fechner H, Knowlton KU, Isik A, Pauschinger M, Zeichhardt H, Schultheiss HP. PMID: 16924471.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    90. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science. 2006 Jul 07; 313(5783):94-7. Trifilo MJ, Yajima T, Gu Y, Dalton N, Peterson KL, Race RE, Meade-White K, Portis JL, Masliah E, Knowlton KU, Chesebro B, Oldstone MB. PMID: 16825571; PMCID: PMC1820586.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    91. Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol. 2006 Jun 19; 173(6):905-16. Bang ML, Li X, Littlefield R, Bremner S, Thor A, Knowlton KU, Lieber RL, Chen J. PMID: 16769824; PMCID: PMC2063916.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    92. Unsolved medical issues and new targets for further research in viral myocarditis and dilated cardiomyopathy. Ernst Schering Res Found Workshop. 2006; (55):19-35. Knowlton KU. PMID: 16329655.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    93. Long-term cardiac gene expression using a coxsackieviral vector. J Mol Cell Cardiol. 2005 May; 38(5):745-51. Lim BK, Shin JO, Lee SC, Kim DK, Choi DJ, Choe SC, Knowlton KU, Jeon ES. PMID: 15850568.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    94. Highlights of the year in JACC 2004. J Am Coll Cardiol. 2005 Jan 04; 45(1):137-53. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Narula J, Sahn D, Tsimikas S. PMID: 15629388.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    95. Interleukin-10: biomarker or pathologic cytokine in fulminant myocarditis? J Am Coll Cardiol. 2004 Sep 15; 44(6):1298-300. Knowlton KU, Yajima T. PMID: 15364335.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    96. Chronic thromboembolic pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):453-66, vii. Auger WR, Kerr KM, Kim NH, Ben-Yehuda O, Knowlton KU, Fedullo PF. PMID: 15302364.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    97. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. J Biol Chem. 2004 Apr 30; 279(18):18497-503. Dörner A, Xiong D, Couch K, Yajima T, Knowlton KU. PMID: 14978041.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    98. Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Circulation. 2004 Jan 06; 109(1):18-22. Kim NH, Fesler P, Channick RN, Knowlton KU, Ben-Yehuda O, Lee SH, Naeije R, Rubin LJ. PMID: 14699009.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    99. Highlights of the year in JACC 2003. J Am Coll Cardiol. 2003 Dec 17; 42(12):2156-66. DeMaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Tsimikas S. PMID: 15560019.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    100. Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside. Med Microbiol Immunol. 2004 May; 193(2-3):121-6. Badorff C, Knowlton KU. PMID: 12920582.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    101. Electrocardiographic manifestations: wide complex tachycardia due to accessory pathway. J Emerg Med. 2003 Apr; 24(3):295-301. Nelson JA, Knowlton KU, Harrigan R, Pollack ML, Chan TC. PMID: 12676301.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    102. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. PMID: 12588885; PMCID: PMC151924.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    103. Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by Coxsackievirus 2A protease. J Biol Chem. 2003 Feb 14; 278(7):4449-57. Zhao X, Lamphear BJ, Xiong D, Knowlton K, Rhoads RE. PMID: 12475969.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    104. Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. Nat Med. 2002 Aug; 8(8):872-7. Xiong D, Lee GH, Badorff C, Dorner A, Lee S, Wolf P, Knowlton KU. PMID: 12118246.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    105. Apoptosis and oncosis in the early progression of left ventricular dysfunction in the cardiomyopathic hamster. Basic Res Cardiol. 2002 Jan; 97(1):65-75. Ryoke T, Gu Y, Ikeda Y, Martone ME, Oh SS, Jeon ES, Knowlton KU, Ross J. PMID: 12004790.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    106. Urban history, urban health. Am J Public Health. 2001 Dec; 91(12):1944-6. Knowlton K. PMID: 11726370; PMCID: PMC1446909.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    107. Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling: implications for mortality and early viral replication. Circulation. 2001 Feb 06; 103(5):756-61. Wessely R, Klingel K, Knowlton KU, Kandolf R. PMID: 11156890.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    108. The immune response following myocardial infarction: a role for T-cell-mediated myocyte damage. J Mol Cell Cardiol. 2000 Dec; 32(12):2107-10. Knowlton KU. PMID: 11112986.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    109. Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: A protective mechanism against enteroviral cardiomyopathy. Circulation. 2000 Oct 31; 102(18):2276-81. Badorff C, Fichtlscherer B, Rhoads RE, Zeiher AM, Muelsch A, Dimmeler S, Knowlton KU. PMID: 11056105.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    110. Dissociation of sarcoglycans and the dystrophin carboxyl terminus from the sarcolemma in enteroviral cardiomyopathy. Circ Res. 2000 Sep 15; 87(6):489-95. Lee GH, Badorff C, Knowlton KU. PMID: 10988241.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    111. Enteroviral cardiomyopathy: bad news for the dystrophin-glycoprotein complex. Herz. 2000 May; 25(3):227-32. Badorff C, Lee GH, Knowlton KU. PMID: 10904843.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    112. Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue. J Biol Chem. 2000 Apr 14; 275(15):11191-7. Badorff C, Berkely N, Mehrotra S, Talhouk JW, Rhoads RE, Knowlton KU. PMID: 10753926.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    113. Inflammatory pathways and cardiac repair: the affliction of infarction. Nat Med. 1999 Oct; 5(10):1122-3. Knowlton KU, Chien KR. PMID: 10502807.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    114. The immune system in viral myocarditis: maintaining the balance. Circ Res. 1999 Sep 17; 85(6):559-61. Knowlton KU, Badorff C. PMID: 10488059.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    115. Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat Med. 1999 Mar; 5(3):320-6. Badorff C, Lee GH, Lamphear BJ, Martone ME, Campbell KP, Rhoads RE, Knowlton KU. PMID: 10086389.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    116. Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? J Virol. 1999 Jan; 73(1):709-17. Kerekatte V, Keiper BD, Badorff C, Cai A, Knowlton KU, Rhoads RE. PMID: 9847377; PMCID: PMC103878.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    117. Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy. J Clin Invest. 1998 Oct 01; 102(7):1444-53. Wessely R, Klingel K, Santana LF, Dalton N, Hongo M, Jonathan Lederer W, Kandolf R, Knowlton KU. PMID: 9769337; PMCID: PMC508992.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    118. Low-level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes. Circulation. 1998 Aug 04; 98(5):450-7. Wessely R, Henke A, Zell R, Kandolf R, Knowlton KU. PMID: 9714096.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    119. NF-kappaB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout mice. J Virol. 1998 Jul; 72(7):5654-60. Schwarz EM, Badorff C, Hiura TS, Wessely R, Badorff A, Verma IM, Knowlton KU. PMID: 9621024; PMCID: PMC110231.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    120. Bcl-2 slows in vitro breast cancer growth despite its antiapoptotic effect. J Surg Res. 1998 Apr; 76(1):22-6. Knowlton K, Mancini M, Creason S, Morales C, Hockenbery D, Anderson BO. PMID: 9695733.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    121. Flow cytometric measurement of mitochondrial mass and function: a novel method for assessing chemoresistance. Ann Surg Oncol. 1998 Apr-May; 5(3):287-95. Mancini M, Sedghinasab M, Knowlton K, Tam A, Hockenbery D, Anderson BO. PMID: 9607633.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    122. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem. 1997 Feb 28; 272(9):5783-91. Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR. PMID: 9038192.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    123. Alpha 1-adrenergic stimulation inhibits 3,5,3'-triiodothyronine-induced expression of the rat heart sarcoplasmic reticulum Ca2+ adenosine triphosphatase gene. Endocrinology. 1997 Jan; 138(1):114-20. Wu PS, Moriscot AS, Knowlton KU, Hilal-Dandan R, He H, Dillmann WH. PMID: 8977393.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    124. A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3. J Virol. 1996 Nov; 70(11):7811-8. Knowlton KU, Jeon ES, Berkley N, Wessely R, Huber S. PMID: 8892902; PMCID: PMC190851.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    125. Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. J Clin Invest. 1995 Sep; 96(3):1311-8. Knowlton KU, Rockman HA, Itani M, Vovan A, Seidman CE, Chien KR. PMID: 7657806; PMCID: PMC185753.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    126. Regulated expression of a contractile protein gene correlates with recovery of contractile function after reversible metabolic inhibition in cultured myocytes. J Mol Cell Cardiol. 1995 Jan; 27(1):551-61. Barry WH, Hamilton CA, Knowlton KU. PMID: 7760376.
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    127. Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. J Biol Chem. 1994 May 06; 269(18):13490-6. LaMorte VJ, Thorburn J, Absher D, Spiegel A, Brown JH, Chien KR, Feramisco JR, Knowlton KU. PMID: 8175782.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    128. The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 1993 Jul 25; 268(21):15374-80. Knowlton KU, Michel MC, Itani M, Shubeita HE, Ishihara K, Brown JH, Chien KR. PMID: 8393439.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    129. Transcriptional regulation during cardiac growth and development. Annu Rev Physiol. 1993; 55:77-95. Chien KR, Zhu H, Knowlton KU, Miller-Hance W, van-Bilsen M, O'Brien TX, Evans SM. PMID: 8466192.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    130. Peripartum vascular collapse Dissection of a genetic disease. Trends Cardiovasc Med. 1992 Jul-Aug; 2(4):125-8. Rockman HA, Knowlton KU. PMID: 21239257.
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    131. Two brothers with unexplained cardiomegaly Initial clues to the molecular basis of a hereditary cardiac disease. Trends Cardiovasc Med. 1992 Jan-Feb; 2(1):2-5. Ross RS, Knowlton KU. PMID: 21239280.
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    132. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J. 1991 Dec; 5(15):3037-46. Chien KR, Knowlton KU, Zhu H, Chien S. PMID: 1835945.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    133. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8277-81. Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, Ross J, Chien KR. PMID: 1832775; PMCID: PMC52490.
      View in: PubMed   Mentions: 362     Fields:    Translation:AnimalsCells
    134. Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. J Biol Chem. 1991 Apr 25; 266(12):7759-68. Knowlton KU, Baracchini E, Ross RS, Harris AN, Henderson SA, Evans SM, Glembotski CC, Chien KR. PMID: 1850419.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    135. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 1990 Nov 25; 265(33):20555-62. Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotski CC, Brown JH, Chien KR. PMID: 2173712.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    136. Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. J Clin Invest. 1990 Feb; 85(2):462-7. Maisel AS, Knowlton KU, Fowler P, Rearden A, Ziegler MG, Motulsky HJ, Insel PA, Michel MC. PMID: 2153706; PMCID: PMC296446.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    137. Cardiovascular molecular biology. Introduction to the series. Circulation. 1989 Aug; 80(2):219-33. Chien KR, Knowlton KU. PMID: 2502325.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    138. Catheter-directed neodymium:YAG laser injury of the left ventricle for arrhythmia ablation: dosimetry and hemodynamic, hematologic, and electrophysiologic effects. Lasers Surg Med. 1989; 9(5):446-53. Vincent GM, Fox J, Knowlton K, Dixon JA. PMID: 2811567.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    139. The effect of adrenal stimulation with adrenocorticotrophic hormone on the excretion of dehydroisoandrosterone in man. Endocrinology. 1951 May; 48(5):489-505. LANDAU RL, KNOWLTON K, LUGIBIHL K, KENYON AT. PMID: 14840409.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    140. The determination of urinary dehydroisoandrosterone in normal men and women and in adrenal disease. Endocrinology. 1951 May; 48(5):506-17. LANDAU RL, KNOWLTON K, LUGIBIHL K, MUNSON PL. PMID: 14840410.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    141. The significance of urinary dehydroisoandrosterone. J Clin Invest. 1950 Jun; 29(6):829-30. LANDAU RL, KNOWLTON K, LUGIBIHL K. PMID: 15436777.
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    142. The anabolic effects of chorionic gonadotropin in normal young men. J Clin Invest. 1950 May; 29(5):619-29. LANDAU RL, KNOWLTON K, LUGIBIHL K, BRANDT M, KENYON AT. PMID: 15415466; PMCID: PMC436099.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    143. The metabolic effects of chorionic gonadotrophins in young men. J Clin Invest. 1948 Jul; 27(4):545. LANDAU RL, KNOWLTON K. PMID: 18935175.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    144. The metabolic response to chorionic gonadotropin stimulation in young men. J Clin Endocrinol Metab. 1948 Jul; 8(7):600. KNOWLTON K, KENYON AT. PMID: 18869622.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    145. The effect of starvation on urinary 17-ketosteroid excretion. J Clin Endocrinol Metab. 1948 Feb; 8(2):133-45. LANDAU RL, KNOWLTON K, et al. PMID: 18907980.
      View in: PubMed   Mentions: 4     Fields:    
    146. STUDIES ON EXPERIMENTAL AND CLINICAL HYPOCHLOREMIA IN MAN. J Clin Invest. 1943 Jan; 22(1):95-102. Kirsner JB, Palmer WL, Knowlton K. PMID: 16694984; PMCID: PMC435212.
      View in: PubMed   Mentions: 1     Fields:    
    147. ACID-BASE BALANCE, RENAL FUNCTION, AND GASTRIC SECRETION DURING HYPOCHLOREMIA IN THE DOG. J Clin Invest. 1941 May; 20(3):303-12. Kirsner JB, Knowlton K. PMID: 16694836; PMCID: PMC435060.
      View in: PubMed   Mentions: 1     Fields:    
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