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Kirk Knowlton

TitleRecall Hcomp
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9300 Campus Point Drive #7411
La Jolla CA 92037
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of mTOR, a Component of the Akt Pathway, in Regulating Cardiac Function
    NIH/NHLBI R01HL078797Dec 1, 2004 - Nov 30, 2014
    Role: Principal Investigator
    Dystrophin-glycoprotein complex in viral cardiomyopathy
    NIH/NHLBI R01HL066424Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    Cardiac SOCS Proteins: A Role in Enterovirus Infection
    NIH/NHLBI R01HL057365Dec 5, 1998 - Apr 30, 2009
    Role: Principal Investigator
    MOLECULAR PHYSIOLOGY OF HEART FAILURE
    NIH/NHLBI P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Co-Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH/NHLBI P01HL046345Feb 1, 1992 - Jun 30, 2014
    Role: Principal Investigator
    REGULATION OF ANF GENE DURING VENTRICULAR HYPERTROPHY
    NIH/NHLBI K08HL002618Aug 1, 1991 - Jul 31, 1997
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    Training In Cardiovascular Physiology & Pharmacology
    NIH/NHLBI T32HL007444Jul 1, 1979 - Jun 30, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Knighton AJ, Grissom CK, Knowlton K, Sean Esplin M, Graydon T, Srivastava R. How Community-Based Health Systems Can Embrace Research in the Fee-for-Value Era. Qual Manag Health Care. 2018 Jul/Sep; 27(3):180-182. PMID: 29944632.
      View in: PubMed
    2. Knight S, Min DB, Le VT, Meredith KG, Dhar R, Biswas S, Jensen KR, Mason SM, Ethington JD, Lappe DL, Muhlestein JB, Anderson JL, Knowlton K. Implementation of a cardiac PET stress program: comparison of outcomes to the preceding SPECT era. JCI Insight. 2018 May 03; 3(9). PMID: 29720565.
      View in: PubMed
    3. Muhlestein JB, May HT, Galenko O, Knowlton K, Otvos JD, Connelly MA, Lappe DL, Anderson JL. GlycA and hsCRP are independent and additive predictors of future cardiovascular events among patients undergoing angiography: The intermountain heart collaborative study. Am Heart J. 2018 Apr 06; 202:27-32. PMID: 29803983.
      View in: PubMed
    4. Anderson JL, Knowlton K, May HT, Bair TL, Armstrong SO, Lappé DL, Muhlestein JB. Temporal changes in statin prescription and intensity at discharge and impact on outcomes in patients with newly diagnosed atherosclerotic cardiovascular disease-Real-world experience within a large integrated health care system: The IMPRES study. J Clin Lipidol. 2018 Mar 30. PMID: 29703626.
      View in: PubMed
    5. Mason S, Osborn JS, Dhar R, Tonkin A, Ethington JD, Le V, Benuzillo J, Lappe DL, Knowlton K, Bunch TJ, Anderson JL. Real world MRI experience with nonconditional and conditional cardiac rhythm devices after MagnaSafe. J Cardiovasc Electrophysiol. 2017 Dec; 28(12):1468-1474. PMID: 28960745.
      View in: PubMed
    6. May HT, Horne BD, Knight S, Knowlton K, Bair TL, Lappé DL, Le VT, Muhlestein JB. The association of depression at any time to the risk of death following coronary artery disease diagnosis. Eur Heart J Qual Care Clin Outcomes. 2017 Oct 01; 3(4):296-302. PMID: 28950317.
      View in: PubMed
    7. Knowlton K. Myocarditis: An Intersection Between Genetic and Acquired Causes of Human Cardiomyopathy. J Am Coll Cardiol. 2017 Apr 04; 69(13):1666-1668. PMID: 28359510.
      View in: PubMed
    8. Peter AK, Bradford WH, Dalton ND, Gu Y, Chao CJ, Peterson KL, Knowlton K. Increased Echogenicity and Radiodense Foci on Echocardiogram and MicroCT in Murine Myocarditis. PLoS One. 2016; 11(8):e0159971. PMID: 27486657; PMCID: PMC4972301.
    9. Zhang Z, Mu Y, Veevers J, Peter AK, Manso AM, Bradford WH, Dalton ND, Peterson KL, Knowlton K, Ross RS, Zhou X, Chen J. Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. Circ Heart Fail. 2016 Aug; 9(8). PMID: 27502369; PMCID: PMC4979611 [Available on 08/01/17].
    10. Lao DH, Esparza MC, Bremner SN, Banerjee I, Zhang J, Veevers J, Bradford WH, Gu Y, Dalton ND, Knowlton K, Peterson KL, Lieber RL, Chen J. Lmo7 is dispensable for skeletal muscle and cardiac function. Am J Physiol Cell Physiol. 2015 Oct 01; 309(7):C470-9. PMID: 26157009; PMCID: PMC4593772 [Available on 10/01/16].
    11. Lee NS, Blanchard DG, Knowlton K, McDivit AM, Pretorius V, Madani MM, Fedullo PF, Kerr KM, Kim NH, Poch DS, Auger WR, Daniels LB. Prevalence of coronary artery-pulmonary artery collaterals in patients with chronic thromboembolic pulmonary hypertension. Pulm Circ. 2015 Jun; 5(2):313-21. PMID: 26064456; PMCID: PMC4449242.
    12. Lim BK, Peter AK, Xiong D, Narezkina A, Yung A, Dalton ND, Hwang KK, Yajima T, Chen J, Knowlton K. Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy. J Clin Invest. 2013 Dec; 123(12):5146-51. PMID: 24200690; PMCID: PMC3859391.
    13. Oba T, Yasukawa H, Hoshijima M, Sasaki K, Futamata N, Fukui D, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Minami T, Nakamura K, Kang D, Yajima T, Knowlton K, Imaizumi T. Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol. 2012 Feb 28; 59(9):838-52. PMID: 22361405.
      View in: PubMed
    14. Blasius AL, Dubin AE, Petrus MJ, Lim BK, Narezkina A, Criado JR, Wills DN, Xia Y, Moresco EM, Ehlers C, Knowlton K, Patapoutian A, Beutler B. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19413-8. PMID: 22087007; PMCID: PMC3228463.
    15. Yajima T, Murofushi Y, Zhou H, Park S, Housman J, Zhong ZH, Nakamura M, Machida M, Hwang KK, Gu Y, Dalton ND, Yajima T, Yasukawa H, Peterson KL, Knowlton K. Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias. Circulation. 2011 Dec 13; 124(24):2690-701. PMID: 22082679; PMCID: PMC3253669.
    16. Peter AK, Cheng H, Ross RS, Knowlton K, Chen J. The costamere bridges sarcomeres to the sarcolemma in striated muscle. Prog Pediatr Cardiol. 2011 May; 31(2):83-88. PMID: 24039381.
      View in: PubMed
    17. Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton K, Sheikh F, Chen J. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet. 2011 May 01; 20(9):1751-62. PMID: 21303826; PMCID: PMC3071671.
    18. Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans SM, Knowlton K, Peterson KL, Chen J. Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res. 2010 Aug 06; 107(3):348-56. PMID: 20538684; PMCID: PMC3684396.
    19. Yajima T, Knowlton K. Viral myocarditis: from the perspective of the virus. Circulation. 2009 May 19; 119(19):2615-24. PMID: 19451363.
      View in: PubMed
    20. Knowlton K, Lim BK. Viral myocarditis: is infection of the heart required? J Am Coll Cardiol. 2009 Apr 07; 53(14):1227-8. PMID: 19341865.
      View in: PubMed
    21. Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton K. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug; 118(8):2758-70. PMID: 18636119; PMCID: PMC2467382.
    22. Knowlton K. CVB infection and mechanisms of viral cardiomyopathy. Curr Top Microbiol Immunol. 2008; 323:315-35. PMID: 18357777.
      View in: PubMed
    23. Wang YX, da Cunha V, Vincelette J, White K, Velichko S, Xu Y, Gross C, Fitch RM, Halks-Miller M, Larsen BR, Yajima T, Knowlton K, Vergona R, Sullivan ME, Croze E. Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H69-76. PMID: 17434974.
      View in: PubMed
    24. Xiong D, Yajima T, Lim BK, Stenbit A, Dublin A, Dalton ND, Summers-Torres D, Molkentin JD, Duplain H, Wessely R, Chen J, Knowlton K. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation. 2007 Jan 02; 115(1):94-102. PMID: 17190866.
      View in: PubMed
    25. Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton K. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. PMID: 17101849.
      View in: PubMed
    26. Sheikh F, Chen Y, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton K, Peterson KL, Perriard JC, Chen J. alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation. 2006 Sep 05; 114(10):1046-55. PMID: 16923756.
      View in: PubMed
    27. Trifilo MJ, Yajima T, Gu Y, Dalton N, Peterson KL, Race RE, Meade-White K, Portis JL, Masliah E, Knowlton K, Chesebro B, Oldstone MB. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science. 2006 Jul 07; 313(5783):94-7. PMID: 16825571; PMCID: PMC1820586.
    28. Bang ML, Li X, Littlefield R, Bremner S, Thor A, Knowlton K, Lieber RL, Chen J. Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol. 2006 Jun 19; 173(6):905-16. PMID: 16769824; PMCID: PMC2063916.
    29. Knowlton K. Unsolved medical issues and new targets for further research in viral myocarditis and dilated cardiomyopathy. Ernst Schering Res Found Workshop. 2006; (55):19-35. PMID: 16329655.
      View in: PubMed
    30. Lim BK, Shin JO, Lee SC, Kim DK, Choi DJ, Choe SC, Knowlton K, Jeon ES. Long-term cardiac gene expression using a coxsackieviral vector. J Mol Cell Cardiol. 2005 May; 38(5):745-51. PMID: 15850568.
      View in: PubMed
    31. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton K, Lew WY, Narula J, Sahn D, Tsimikas S. Highlights of the year in JACC 2004. J Am Coll Cardiol. 2005 Jan 04; 45(1):137-53. PMID: 15629388.
      View in: PubMed
    32. Knowlton K, Yajima T. Interleukin-10: biomarker or pathologic cytokine in fulminant myocarditis? J Am Coll Cardiol. 2004 Sep 15; 44(6):1298-300. PMID: 15364335.
      View in: PubMed
    33. Auger WR, Kerr KM, Kim NH, Ben-Yehuda O, Knowlton K, Fedullo PF. Chronic thromboembolic pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):453-66, vii. PMID: 15302364.
      View in: PubMed
    34. Dörner A, Xiong D, Couch K, Yajima T, Knowlton K. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. J Biol Chem. 2004 Apr 30; 279(18):18497-503. PMID: 14978041.
      View in: PubMed
    35. Kim NH, Fesler P, Channick RN, Knowlton K, Ben-Yehuda O, Lee SH, Naeije R, Rubin LJ. Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Circulation. 2004 Jan 06; 109(1):18-22. PMID: 14699009.
      View in: PubMed
    36. DeMaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton K, Lew WY, Tsimikas S. Highlights of the year in JACC 2003. J Am Coll Cardiol. 2003 Dec 17; 42(12):2156-66. PMID: 15560019.
      View in: PubMed
    37. Badorff C, Knowlton K. Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside. Med Microbiol Immunol. 2004 May; 193(2-3):121-6. PMID: 12920582.
      View in: PubMed
    38. Nelson JA, Knowlton K, Harrigan R, Pollack ML, Chan TC. Electrocardiographic manifestations: wide complex tachycardia due to accessory pathway. J Emerg Med. 2003 Apr; 24(3):295-301. PMID: 12676301.
      View in: PubMed
    39. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton K. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. PMID: 12588885; PMCID: PMC151924.
    40. Zhao X, Lamphear BJ, Xiong D, Knowlton K, Rhoads RE. Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by Coxsackievirus 2A protease. J Biol Chem. 2003 Feb 14; 278(7):4449-57. PMID: 12475969.
      View in: PubMed
    41. Xiong D, Lee GH, Badorff C, Dorner A, Lee S, Wolf P, Knowlton K. Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. Nat Med. 2002 Aug; 8(8):872-7. PMID: 12118246.
      View in: PubMed
    42. Ryoke T, Gu Y, Ikeda Y, Martone ME, Oh SS, Jeon ES, Knowlton K, Ross J. Apoptosis and oncosis in the early progression of left ventricular dysfunction in the cardiomyopathic hamster. Basic Res Cardiol. 2002 Jan; 97(1):65-75. PMID: 12004790.
      View in: PubMed
    43. Knowlton K, Jeon ES, Berkley N, Wessely R, Huber S. A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3. J Virol. 1996 Nov; 70(11):7811-8. PMID: 8892902; PMCID: PMC190851.