Renate Pilz

Title(s)Professor In Residence, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Research Interests
    Research Topics: Basic Tumor Biology, Signal Transduction

    Control of Cell Growth, Differentiation and Survival by Ras- and Rho-related Proteins.
    Ras- and Rho-related proteins are small GTPases activated downstream of multiple receptors that control many cellular processes including cell cycle progression, apoptosis, cell motility, and cellular differentiation. Since they promote transformation and tumor metastasis, they represent important targets for cancer therapy. We have investigated the effects of prenylation inhibitors (agents that inhibit important post-translational modifications of Ras and Rho) on signaling in solid tumors and leukemic cells. Through a proteomics approach, we have identified novel Rho effector proteins, and defined their functions in cancer cells. We are also interested in the cross-talk between Ras and Rho and other signaling pathways, and are examining mechanisms whereby cAMP- and cGMP-dependent protein kinases regulate the activities of these proteins.

    Regulation of Gene Expression by NO/cGMP/cGMP-dependent Protein Kinases.
    We have identified a number of genes and transcription factors regulated by nitric oxide (NO) and cGMP through activation of cGMP-dependent protein kinases (PKGs), and have characterized different mechanisms of transcriptional regulation by PKGs. We are studying the role of PKG isoforms in the regulation of genes important for growth and differentiation of primary vascular smooth muscle cells, osteoblasts, and mesenchymal stem cells. We found that type II PKG plays a crucial role in osteoblast mechano-transduction and estrogen signaling, and have defined mechanisms whereby PKG II activates Src, Erk and Akt in cells. We found that type I PKG promotes cell survival and motility in several systems, and are investigating mechanisms whereby NO/cGMP signaling can affect breast cancer invasiveness. We have identi¬fied isoform-specific PKG anchoring proteins and are determining how they restrict and define cGMP signaling within cells.

    Education and Training
    Baccalaureate Mathematics/Physics - Kranich Gymnasium,Salzgitter, Germany - 1974
    MD - Medical School of Hannover, Hannover, Germany - 1981
    Research Fellow - University of California, San Diego - 1981-1983
    Intern - University of California, San Diego - 1983-1984
    Resident - University of Cologne, Germany - 1984-1985
    Resident - University of California, San Diego - 1985-1987
    Fellow Hematology/Oncology - University of California, San Diego - 1987-1990

    Collapse Research 
    Collapse Research Activities and Funding
    PKG Regulation of Sirtuin 1 as a Novel Treatment Strategy for Age-related Osteoporosis
    NIH R01AG070778Sep 5, 2021 - May 31, 2026
    Role: Principal Investigator
    Targeting defective NO/cGMP signaling as novel therapy for diabetic osteoporosis
    NIH R01AR068601Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Mechanisms of vascular pathology from abnormal protein kinase G signaling
    NIH R01HL132141Apr 1, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Testing novel NO/cGMP-based bone-anabolic agents in mouse models of osteoporosis
    NIH R21AR065658Jul 10, 2015 - Apr 30, 2018
    Role: Principal Investigator
    cGMP-dependent Protein Kinase Function in Osteoblast Mechanotransduction
    NIH R01AR051300Sep 1, 1998 - May 31, 2016
    Role: Principal Investigator
    NIH R01GM055586Sep 1, 1998 - Aug 31, 2004
    Role: Principal Investigator
    NIH K08CA001548Aug 16, 1990 - Jul 31, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A plasma membrane-associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells. Sci Signal. 2024 Jan 30; 17(821):eadi7861. Kalyanaraman H, Casteel DE, China SP, Zhuang S, Boss GR, Pilz RB. PMID: 38289986; PMCID: PMC10916501.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. The Antioxidant/Nitric Oxide-Quenching Agent Cobinamide Prevents Aortic Disease in a Mouse Model of Marfan Syndrome. JACC Basic Transl Sci. 2024 Jan; 9(1):46-62. Kalyanaraman H, Casteel DE, Cabriales JA, Tat J, Zhuang S, Chan A, Dretchen KL, Boss GR, Pilz RB. PMID: 38362350; PMCID: PMC10864892.
      View in: PubMed   Mentions:
    3. The vitamin B12 analog cobinamide ameliorates azide toxicity in cells, Drosophila melanogaster, and mice. Clin Toxicol (Phila). 2023 04; 61(4):212-222. Tat J, Chang SC, Link CD, Razo-Lopez S, Ingerto MJ, Katebian B, Chan A, Kalyanaraman H, Pilz RB, Boss GR. PMID: 37010385; PMCID: PMC10348668.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3. J Biol Chem. 2023 04; 299(4):104584. Hu T, Kalyanaraman H, Pilz RB, Casteel DE. PMID: 36889588; PMCID: PMC10124902.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice. J Bone Miner Res. 2023 01; 38(1):171-185. Kalyanaraman H, Pal China S, Cabriales JA, Moininazeri J, Casteel DE, Garcia JJ, Wong VW, Chen A, Sah RL, Boss GR, Pilz RB. PMID: 36371651; PMCID: PMC9825661.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice. PNAS Nexus. 2022 Sep; 1(4):pgac191. Chang S, Tat J, China SP, Kalyanaraman H, Zhuang S, Chan A, Lai C, Radic Z, Abdel-Rahman EA, Casteel DE, Pilz RB, Ali SS, Boss GR. PMID: 36276587; PMCID: PMC9578022.
      View in: PubMed   Mentions: 2  
    7. PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells. J Biol Chem. 2022 08; 298(8):102175. Aminzai S, Hu T, Pilz RB, Casteel DE. PMID: 35752367; PMCID: PMC9293632.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Development of sodium tetrathionate as a cyanide and methanethiol antidote. Clin Toxicol (Phila). 2022 Mar; 60(3):332-341. Chan A, Lee J, Bhadra S, Bortey-Sam N, Hendry-Hofer TB, Bebarta VS, Mahon SB, Brenner M, Logue B, Pilz RB, Boss GR. PMID: 34328378; PMCID: PMC8800944.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. Br J Pharmacol. 2022 06; 179(11):2413-2429. Schwaerzer GK, Casteel DE, Cividini F, Kalyanaraman H, Zhuang S, Gu Y, Dalton ND, Peterson KL, Dillmann WH, Boss GR, Pilz RB. PMID: 34000062; PMCID: PMC9926932.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Sodium azide poisoning: a narrative review. Clin Toxicol (Phila). 2021 Aug; 59(8):683-697. Tat J, Heskett K, Satomi S, Pilz RB, Golomb BA, Boss GR. PMID: 34128439; PMCID: PMC8349855.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    11. Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity. Sci Rep. 2020 11 16; 10(1):19907. Wahwah N, Dhar D, Chen H, Zhuang S, Chan A, Casteel DE, Kalyanaraman H, Pilz RB, Boss GR. PMID: 33199755; PMCID: PMC7670436.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Assessment of High School Students' Participation in Blood Donation and Registration as an Organ Donor. JAMA Netw Open. 2020 09 01; 3(9):e2016377. Tat J, Hays B, Teachworth M, Kuo A, Pilz RB, Golomb BA, Boss GR. PMID: 32945872; PMCID: PMC7501534.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. J Biol Chem. 2020 07 24; 295(30):10394-10405. Chan MH, Aminzai S, Hu T, Taran A, Li S, Kim C, Pilz RB, Casteel DE. PMID: 32506052; PMCID: PMC7383375.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing. JCI Insight. 2020 05 07; 5(9). Schall N, Garcia JJ, Kalyanaraman H, China SP, Lee JJ, Sah RL, Pfeifer A, Pilz RB. PMID: 32315291; PMCID: PMC7253025.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat Commun. 2019 08 06; 10(1):3533. Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB. PMID: 31387997; PMCID: PMC6684604.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    16. cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss. J Endocrinol. 2018 09; 238(3):203-219. Ramdani G, Schall N, Kalyanaraman H, Wahwah N, Moheize S, Lee JJ, Sah RL, Pfeifer A, Casteel DE, Pilz RB. PMID: 29914933; PMCID: PMC6086127.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. Nitric oxide and cyclic GMP functions in bone. Nitric Oxide. 2018 06 01; 76:62-70. Kalyanaraman H, Schall N, Pilz RB. PMID: 29550520; PMCID: PMC9990405.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    18. Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes. Diabetes. 2018 04; 67(4):607-623. Kalyanaraman H, Schwaerzer G, Ramdani G, Castillo F, Scott BT, Dillmann W, Sah RL, Casteel DE, Pilz RB. PMID: 29301852; PMCID: PMC5860855.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    19. The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43. J Biol Chem. 2017 05 19; 292(20):8262-8268. Kalyanaraman H, Zhuang S, Pilz RB, Casteel DE. PMID: 28360102; PMCID: PMC5437233.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    20. Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. Ann Emerg Med. 2017 Jun; 69(6):718-725.e4. Bebarta VS, Brittain M, Chan A, Garrett N, Yoon D, Burney T, Mukai D, Babin M, Pilz RB, Mahon SB, Brenner M, Boss GR. PMID: 28041825; PMCID: PMC5446299.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    21. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. J Bone Miner Res. 2017 01; 32(1):46-59. Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel DE, Pilz RB. PMID: 27391172; PMCID: PMC5199609.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    22. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016 Feb 15; 6:20831. Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. PMID: 26877209; PMCID: PMC4753484.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    23. Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection. J Med Chem. 2015 Feb 26; 58(4):1750-9. Chan A, Jiang J, Fridman A, Guo LT, Shelton GD, Liu MT, Green C, Haushalter KJ, Patel HH, Lee J, Yoon D, Burney T, Mukai D, Mahon SB, Brenner M, Pilz RB, Boss GR. PMID: 25650735; PMCID: PMC4494098.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    24. Soluble guanylate cyclase as a novel treatment target for osteoporosis. Endocrinology. 2014 Dec; 155(12):4720-30. Joshua J, Schwaerzer GK, Kalyanaraman H, Cory E, Sah RL, Li M, Vaida F, Boss GR, Pilz RB. PMID: 25188528; PMCID: PMC4239425.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    25. Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis. Mol Cell. 2014 Jul 17; 55(2):264-76. Saha A, Connelly S, Jiang J, Zhuang S, Amador DT, Phan T, Pilz RB, Boss GR. PMID: 24981175; PMCID: PMC4104231.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    26. Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor. Sci Signal. 2014 May 20; 7(326):ra48. Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel DE, Frangos JA, Dillmann W, Boss GR, Pilz RB. PMID: 24847117; PMCID: PMC6504257.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    27. CD20-positive plasmablastic lymphoma with excellent response to bortezomib combined with rituximab. Eur J Haematol. 2014 Jul; 93(1):77-80. Yan M, Dong Z, Zhao F, Chauncey T, Deauna-Limayo D, Wang-Rodriguez J, Liu D, Wang HY, Pilz R. PMID: 24528507.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    28. Nitric oxide as a mediator of estrogen effects in osteocytes. Vitam Horm. 2014; 96:247-63. Joshua J, Kalyanaraman H, Marathe N, Pilz RB. PMID: 25189390.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    29. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. Biochem J. 2013 Aug 15; 454(1):91-9. Fridman A, Saha A, Chan A, Casteel DE, Pilz RB, Boss GR. PMID: 23734909.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    30. Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase. Cell Signal. 2013 Dec; 25(12):2374-82. Spitler R, Schwappacher R, Wu T, Kong X, Yokomori K, Pilz RB, Boss GR, Berns MW. PMID: 23920342.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension. J Biol Chem. 2013 Jun 07; 288(23):16557-16566. Schwappacher R, Kilic A, Kojonazarov B, Lang M, Diep T, Zhuang S, Gawlowski T, Schermuly RT, Pfeifer A, Boss GR, Pilz RB. PMID: 23612967; PMCID: PMC3675591.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J Biol Chem. 2012 Nov 02; 287(45):38367-78. Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB. PMID: 22992742; PMCID: PMC3488105.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    33. Protein kinase G and focal adhesion kinase converge on Src/Akt/β-catenin signaling module in osteoblast mechanotransduction. J Biol Chem. 2012 Jun 15; 287(25):21509-19. Rangaswami H, Schwappacher R, Tran T, Chan GC, Zhuang S, Boss GR, Pilz RB. PMID: 22563076; PMCID: PMC3375572.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    34. Pro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II. J Biol Chem. 2012 Jan 06; 287(2):978-88. Marathe N, Rangaswami H, Zhuang S, Boss GR, Pilz RB. PMID: 22117068; PMCID: PMC3256896.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    35. The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning. Clin Toxicol (Phila). 2011 Jun; 49(5):366-73. Chan A, Crankshaw DL, Monteil A, Patterson SE, Nagasawa HT, Briggs JE, Kozocas JA, Mahon SB, Brenner M, Pilz RB, Bigby TD, Boss GR. PMID: 21740135; PMCID: PMC3882312.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    36. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. PMID: 21177494; PMCID: PMC3093297.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    37. A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring. J Biol Chem. 2010 Oct 22; 285(43):32684-32688. Casteel DE, Smith-Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim C. PMID: 20826808; PMCID: PMC2963381.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    38. New facile method to measure cyanide in blood. Anal Chem. 2010 May 15; 82(10):4216-21. Blackledge WC, Blackledge CW, Griesel A, Mahon SB, Brenner M, Pilz RB, Boss GR. PMID: 20420400; PMCID: PMC2889625.
      View in: PubMed   Mentions: 24     Fields:    
    39. Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J Biol Chem. 2009 May 29; 284(22):14796-808. Rangaswami H, Marathe N, Zhuang S, Chen Y, Yeh JC, Frangos JA, Boss GR, Pilz RB. PMID: 19282289; PMCID: PMC2685661.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    40. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem. 2009 Feb 27; 284(9):5807-18. Casteel DE, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB. PMID: 19119139; PMCID: PMC2645831.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    41. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J Biol Chem. 2009 Feb 06; 284(6):3521-8. Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. PMID: 19068483; PMCID: PMC2635033.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    42. cGMP-dependent protein kinase anchoring by IRAG regulates its nuclear translocation and transcriptional activity. Cell Signal. 2008 Jul; 20(7):1392-9. Casteel DE, Zhang T, Zhuang S, Pilz RB. PMID: 18450420; PMCID: PMC2477739.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    43. Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J Infect Dis. 2008 Feb 01; 197(3):457-64. Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. PMID: 18199034.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    44. Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp Biol Med (Maywood). 2007 Dec; 232(11):1432-40. Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, Boss GR. PMID: 18040067.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    45. A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase. J Biol Chem. 2007 Nov 16; 282(46):33367-33380. Zhang T, Zhuang S, Casteel DE, Looney DJ, Boss GR, Pilz RB. PMID: 17878170.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    46. Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol. 2008 Jan 15; 75(2):405-13. Turner SJ, Zhuang S, Zhang T, Boss GR, Pilz RB. PMID: 17920041; PMCID: PMC2228324.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    47. The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide. Exp Biol Med (Maywood). 2007 Jun; 232(6):789-98. Broderick KE, Balasubramanian M, Chan A, Potluri P, Feala J, Belke DD, McCulloch A, Sharma VS, Pilz RB, Bigby TD, Boss GR. PMID: 17526771.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    48. Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Mol Endocrinol. 2007 May; 21(5):1148-62. Broderick KE, Zhang T, Rangaswami H, Zeng Y, Zhao X, Boss GR, Pilz RB. PMID: 17341596.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    49. The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis. FASEB J. 2006 Sep; 20(11):1865-73. Broderick KE, Feala J, McCulloch A, Paternostro G, Sharma VS, Pilz RB, Boss GR. PMID: 16940158.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    50. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood). 2006 May; 231(5):641-9. Broderick KE, Potluri P, Zhuang S, Scheffler IE, Sharma VS, Pilz RB, Boss GR. PMID: 16636313.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    51. Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4. J Biol Chem. 2006 Jun 23; 281(25):16951-16961. Zeng Y, Zhuang S, Gloddek J, Tseng CC, Boss GR, Pilz RB. PMID: 16632465.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    52. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. J Biol Chem. 2005 Nov 18; 280(46):38211-8. Casteel DE, Boss GR, Pilz RB. PMID: 16166082.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    53. Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3. J Biol Chem. 2005 Sep 23; 280(38):32683-92. Zhao X, Zhuang S, Chen Y, Boss GR, Pilz RB. PMID: 16055922.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    54. Role of cyclic GMP in gene regulation. Front Biosci. 2005 May 01; 10:1239-68. Pilz RB, Broderick KE. PMID: 15769622.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    55. Nitric oxide inhibits mammalian methylmalonyl-CoA mutase. J Biol Chem. 2005 Mar 18; 280(11):10073-82. Kambo A, Sharma VS, Casteel DE, Woods VL, Pilz RB, Boss GR. PMID: 15647267.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    56. Nitric oxide scavenging by the cobalamin precursor cobinamide. J Biol Chem. 2005 Mar 11; 280(10):8678-85. Broderick KE, Singh V, Zhuang S, Kambo A, Chen JC, Sharma VS, Pilz RB, Boss GR. PMID: 15632180.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    57. Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation. J Biol Chem. 2004 Mar 12; 279(11):10397-407. Zhuang S, Nguyen GT, Chen Y, Gudi T, Eigenthaler M, Jarchau T, Walter U, Boss GR, Pilz RB. PMID: 14679200.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    58. Regulation of gene expression by cyclic GMP. Circ Res. 2003 Nov 28; 93(11):1034-46. Pilz RB, Casteel DE. PMID: 14645134.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    59. Reactions of nitric oxide with vitamin B12 and its precursor, cobinamide. Biochemistry. 2003 Jul 29; 42(29):8900-8. Sharma VS, Pilz RB, Boss GR, Magde D. PMID: 12873151.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    60. Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol Cell Biol. 2003 Jun; 23(12):4066-82. Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB. PMID: 12773552; PMCID: PMC156132.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    61. Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene. 2002 Sep 12; 21(41):6356-65. Im E, von Lintig FC, Chen J, Zhuang S, Qui W, Chowdhury S, Worley PF, Boss GR, Pilz RB. PMID: 12214276.
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    62. cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions. J Biol Chem. 2002 Oct 04; 277(40):37382-93. Gudi T, Chen JC, Casteel DE, Seasholtz TM, Boss GR, Pilz RB. PMID: 12119292.
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    63. cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I. J Biol Chem. 2002 Aug 30; 277(35):32003-14. Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB. PMID: 12082086.
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    64. Cyclic AMP regulates expression of the RI alpha subunit of cAMP-dependent protein kinase through an alternatively spliced 5' UTR. Eur J Biochem. 2001 Nov; 268(22):5920-9. Dahle MK, Knutsen HK, Taskén KA, Pilz R, Taskén K. PMID: 11722580.
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    65. NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation. Oncogene. 2000 Dec 14; 19(54):6324-33. Gudi T, Casteel DE, Vinson C, Boss GR, Pilz RB. PMID: 11175347.
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    66. Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins. J Biol Chem. 2000 Oct 13; 275(41):31921-9. Qiu W, Zhuang S, von Lintig FC, Boss GR, Pilz RB. PMID: 10931830.
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    67. Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells. Oncogene. 2000 Aug 17; 19(35):4029-34. von Lintig FC, Pilz RB, Boss GR. PMID: 10962559.
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    68. Transcriptional elongation of c-myb is regulated by NF-kappaB (p50/RelB). Oncogene. 1999 Dec 02; 18(51):7360-9. Suhasini M, Pilz RB. PMID: 10602492.
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    69. Nitric oxide and cGMP regulate gene expression in neuronal and glial cells by activating type II cGMP-dependent protein kinase. FASEB J. 1999 Dec; 13(15):2143-52. Gudi T, Hong GK, Vaandrager AB, Lohmann SM, Pilz RB. PMID: 10593861.
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    70. Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase. J Biol Chem. 1999 Apr 02; 274(14):9489-93. Idriss SD, Gudi T, Casteel DE, Kharitonov VG, Pilz RB, Boss GR. PMID: 10092632.
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    71. Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression. Rev Physiol Biochem Pharmacol. 1999; 135:173-209. Eigenthaler M, Lohmann SM, Walter U, Pilz RB. PMID: 9932484.
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    72. Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway. Mol Cell Biol. 1998 Dec; 18(12):6983-94. Suhasini M, Li H, Lohmann SM, Boss GR, Pilz RB. PMID: 9819386; PMCID: PMC109281.
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    73. Deficient post-translational processing of Rap 1A in variant HL-60 cells. Oncogene. 1998 Oct 29; 17(17):2211-23. Scheele JS, Pilz RB, von Lintig FC, Boss GR. PMID: 9811452.
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    74. Decreased phosphorylation of a low molecular weight protein by cGMP-dependent protein kinase in variant HL-60 cells resistant to nitric oxide- and cGMP-induced differentiation. Mol Cell Biochem. 1998 Aug; 185(1-2):111-21. Scheele JS, Pilz RB, Clark G, Gupta N, Loo D, Martis P, Boss GR. PMID: 9746217.
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    75. Regulation of the erythroid transcription factor NF-E2 by cyclic adenosine monophosphate-dependent protein kinase. Blood. 1998 May 01; 91(9):3193-201. Casteel D, Suhasini M, Gudi T, Naima R, Pilz RB. PMID: 9558374.
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    76. cAMP-induced NF-kappaB (p50/relB) binding to a c-myb intronic enhancer correlates with c-myb up-regulation and inhibition of erythroleukemia cell differentiation. Oncogene. 1997 Oct 09; 15(15):1859-70. Suhasini M, Reddy CD, Reddy EP, DiDonato JA, Pilz RB. PMID: 9362453.
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    77. Regulation of gene expression by cyclic GMP-dependent protein kinase requires nuclear translocation of the kinase: identification of a nuclear localization signal. Mol Cell Biol. 1997 Sep; 17(9):5244-54. Gudi T, Lohmann SM, Pilz RB. PMID: 9271402; PMCID: PMC232375.
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    78. A low molecular weight substance purified from human placenta inhibits cAMP-dependent protein kinase and activates protein kinase C. Mol Cell Biochem. 1997 May; 170(1-2):75-83. Talwar N, Pilz RB, Yu Z, Burlingame A, Boss GR. PMID: 9144320.
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    79. A decrease in the intracellular guanosine 5'-triphosphate concentration is necessary for granulocytic differentiation of HL-60 cells, but growth cessation and differentiation are not associated with a change in the activation state of Ras, the transforming principle of HL-60 cells. Cell Growth Differ. 1997 Jan; 8(1):53-9. Pilz RB, Huvar I, Scheele JS, Van den Berghe G, Boss GR. PMID: 8993834.
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    80. Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter. J Biol Chem. 1996 Mar 01; 271(9):4597-600. Gudi T, Huvar I, Meinecke M, Lohmann SM, Boss GR, Pilz RB. PMID: 8617718.
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    81. Nitric oxide-releasing agents and cGMP analogues inhibit murine erythroleukemia cell differentiation and suppress erythroid-specific gene expression: correlation with decreased DNA binding of NF-E2 and altered c-myb mRNA expression. Cell Growth Differ. 1995 Dec; 6(12):1559-66. Suhasini M, Boss GR, Pascual FE, Pilz RB. PMID: 9019161.
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    82. cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation. J Biol Chem. 1995 Apr 21; 270(16):9169-77. Garingo AD, Suhasini M, Andrews NC, Pilz RB. PMID: 7721832.
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    83. Nitric oxide and cGMP analogs activate transcription from AP-1-responsive promoters in mammalian cells. FASEB J. 1995 Apr; 9(7):552-8. Pilz RB, Suhasini M, Idriss S, Meinkoth JL, Boss GR. PMID: 7737465.
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    84. Basis of guanylate cyclase activation by carbon monoxide. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2568-71. Kharitonov VG, Sharma VS, Pilz RB, Magde D, Koesling D. PMID: 7708686; PMCID: PMC42259.
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    85. Isolation and characterization of HL-60 cells resistant to nitroprusside-induced differentiation. J Biol Chem. 1994 Dec 23; 269(51):32155-61. Pilz RB, Berjis M, Idriss SD, Scheele JS, Suhasini M, Gao L, Scheffler IE, Boss GR. PMID: 7798212.
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    86. Identification of a ras-related protein in murine erythroleukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induced differentiation. J Biol Chem. 1994 Jul 15; 269(28):18599-606. Scheele JS, Pilz RB, Quilliam LA, Boss GR. PMID: 8034608.
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    87. Impaired erythroid-specific gene expression in cAMP-dependent protein kinase-deficient murine erythroleukemia cells. J Biol Chem. 1993 Sep 25; 268(27):20252-8. Pilz RB. PMID: 8376386.
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    88. Chemically induced murine erythroleukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes. J Biol Chem. 1992 Aug 15; 267(23):16161-7. Pilz RB, Eigenthaler M, Boss GR. PMID: 1644803.
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    89. Studies on cytosolic guanylate cyclase from human placenta. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):312-20. Idriss SD, Pilz RB, Sharma VS, Boss GR. PMID: 1347448.
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    90. Molecular and genetic characterization of an ornithine decarboxylase-deficient Chinese hamster cell line. J Biol Chem. 1990 May 25; 265(15):8880-6. Pilz RB, Steglich C, Scheffler IE. PMID: 1692838.
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    91. Nucleotide sequence of the Chinese hamster ornithine decarboxylase gene. Nucleic Acids Res. 1989 Dec 25; 17(24):10497. Grens A, Steglich C, Pilz R, Scheffler IE. PMID: 2602162; PMCID: PMC335322.
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    92. Adenosine dialdehyde and nitrous oxide induce HL-60 differentiation. Blood. 1987 Oct; 70(4):1161-4. Pilz RB, Van den Berghe G, Boss GR. PMID: 3651602.
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    93. Induction of HL-60 differentiation by starvation for a single essential amino acid but not by protein synthesis inhibitors. J Clin Invest. 1987 Mar; 79(3):1006-9. Pilz RB, Van den Berghe G, Boss GR. PMID: 3469216; PMCID: PMC424263.
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    94. The synthesis of phosphoribosylpyrophosphate from glucose decreases during amino acid starvation of human lymphoblasts. Adv Exp Med Biol. 1986; 195 Pt B:611-4. Pilz RB, Boss GR. PMID: 2429513.
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    95. Phosphoribosylpyrophosphate synthesis from glucose decreases during amino acid starvation of human lymphoblasts. J Biol Chem. 1985 May 25; 260(10):6054-9. Boss GR, Pilz RB. PMID: 2581946.
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    96. Decreased methionine synthesis in purine nucleoside-treated T and B lymphoblasts and reversal by homocysteine. J Clin Invest. 1984 Oct; 74(4):1262-8. Boss GR, Pilz RB. PMID: 6332827; PMCID: PMC425293.
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    97. The influence of ribose 5-phosphate availability on purine synthesis of cultured human lymphoblasts and mitogen-stimulated lymphocytes. J Biol Chem. 1984 Mar 10; 259(5):2927-35. Pilz RB, Willis RC, Boss GR. PMID: 6699001.
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