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Thomas Prohaska

Title(s)Associate Physician, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia. N Engl J Med. 2025 Aug 30. Bergmark BA, Marston NA, Prohaska TA, Alexander VJ, Zimerman A, Moura FA, Kang YM, Weinland J, Murphy SA, Goodrich EL, Zhang S, Li D, Banach M, Stroes E, Lu MT, Tsimikas S, Giugliano RP, Sabatine MS, Essence–TIMI 73b Investigators. PMID: 40888739.
      View in: PubMed   Mentions:    Fields:    
    2. Effect of olezarsen on routinely measured lipase and amylase levels in familial chylomicronemia syndrome. J Clin Lipidol. 2025 Jul-Aug; 19(4):1109-1118. Alexander VJ, Prohaska TA, Karwatowska-Prokopczuk E, Xia S, Tsimikas S. PMID: 40640035.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression. Immunity. 2025 Apr 08; 58(4):826-842.e8. Cobo I, Murillo-Saich J, Alishala M, Calderon S, Coras R, Hemming B, Inkum F, Rosas F, Takei R, Spann N, Prohaska TA, Alabarse PVG, Jeong SJ, Nickl CK, Cheng A, Li B, Vogel A, Weichhart T, Fuster JJ, Le T, Bradstreet TR, Webber AM, Edelson BT, Razani B, Ebert BL, Taneja R, Terkeltaub R, Bryan RL, Guma M, Glass CK. PMID: 40118070; PMCID: PMC12093573.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Olezarsen in patients with hypertriglyceridemia at high cardiovascular risk: Rationale and design of the Essence-TIMI 73b trial. Am Heart J. 2025 Aug; 286:116-124. Bergmark BA, Marston NA, Prohaska TA, Alexander VJ, Zimerman A, Moura FA, Kang YM, Murphy SA, Zhang S, Lu MT, Karwatowska-Prokopczuk E, Tsimikas S, Giugliano RP, Sabatine MS. PMID: 40081744; PMCID: PMC12065083.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    5. Design and rationale of the CORE-TIMI 72a and CORE2-TIMI 72b trials of olezarsen in patients with severe hypertriglyceridemia. Am Heart J. 2025 Aug; 286:125-135. Marston NA, Bergmark BA, Alexander VJ, Karwatowska-Prokopczuk E, Kang YM, Moura FA, Prohaska TA, Zimerman A, Zhang S, Murphy SA, Tsimikas S, Giugliano RP, Sabatine MS. PMID: 40064331; PMCID: PMC12065585.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Matrix matched calibration to improve trueness of strontium isotope ratios in natural calcium carbonates determined by LA-MC-ICP-MS. Talanta. 2025 Aug 15; 291:127748. Tchaikovsky A, Irrgeher J, Zitek A, Garbe-Schönberg D, Prohaska T. PMID: 40056649.
      View in: PubMed   Mentions:    Fields:    
    7. Green and blue infrastructure as model system for emissions of technology-critical elements. Sci Total Environ. 2024 Jul 15; 934:173364. Trimmel S, Spörl P, Haluza D, Lashin N, Meisel TC, Pitha U, Prohaska T, Puschenreiter M, Rückert E, Spangl B, Wiedenhofer D, Irrgeher J. PMID: 38777068.
      View in: PubMed   Mentions: 1     Fields:    
    8. Mapping elemental solutes at sub-picogram levels during aqueous corrosion of Al alloys using diffusive gradients in thin films (DGT) with LA-ICP-MS. Anal Bioanal Chem. 2024 Jun; 416(14):3373-3388. Mukhametzianova G, Wagner S, Eskinja M, Moshtaghi M, Mori G, Prohaska T. PMID: 38625560; PMCID: PMC11106204.
      View in: PubMed   Mentions: 1     Fields:    
    9. Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome. N Engl J Med. 2024 05 16; 390(19):1781-1792. Stroes ESG, Alexander VJ, Karwatowska-Prokopczuk E, Hegele RA, Arca M, Ballantyne CM, Soran H, Prohaska TA, Xia S, Ginsberg HN, Witztum JL, Tsimikas S, Balance Investigators. PMID: 38587247.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCTClinical Trials
    10. Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk. N Engl J Med. 2024 05 16; 390(19):1770-1780. Bergmark BA, Marston NA, Prohaska TA, Alexander VJ, Zimerman A, Moura FA, Murphy SA, Goodrich EL, Zhang S, Gaudet D, Karwatowska-Prokopczuk E, Tsimikas S, Giugliano RP, Sabatine MS, Bridge–TIMI 73a Investigators. PMID: 38587249.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCTClinical Trials
    11. Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia. N Engl J Med. 2024 02 01; 390(5):476-477. Alexander VJ, Karwatowska-Prokopczuk E, Prohaska TA, Li L, Geary RS, Gouni-Berthold I, Oral EA, Hegele RA, Stroes ESG, Witztum JL, Tsimikas S. PMID: 38294982.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    12. RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression. Mol Cell. 2023 10 05; 83(19):3421-3437.e11. Abe Y, Kofman ER, Almeida M, Ouyang Z, Ponte F, Mueller JR, Cruz-Becerra G, Sakai M, Prohaska TA, Spann NJ, Resende-Coelho A, Seidman JS, Stender JD, Taylor H, Fan W, Link VM, Cobo I, Schlachetzki JCM, Hamakubo T, Jepsen K, Sakai J, Downes M, Evans RM, Yeo GW, Kadonaga JT, Manolagas SC, Rosenfeld MG, Glass CK. PMID: 37751740; PMCID: PMC10591845.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia. J Clin Lipidol. 2023 May-Jun; 17(3):406-411. Prohaska TA, Alexander VJ, Karwatowska-Prokopczuk E, Tami J, Xia S, Witztum JL, Tsimikas S. PMID: 37164837.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    14. Enriched stable 204Pb as tracer at ultra-low levels in clinical investigations. Anal Bioanal Chem. 2023 Jan; 415(2):255-268. Irrgeher J, Berger T, Tchaikovsky A, Tschegg C, Gouya G, Lechner P, Retzmann A, Opper C, Firbas C, Freissmuth M, Peschel-Credner K, Anderle K, Meisslitzer C, Wolzt M, Prohaska T. PMID: 36136113; PMCID: PMC9823027.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis. Front Immunol. 2022; 13:909475. Srikakulapu P, Pattarabanjird T, Upadhye A, Bontha SV, Osinski V, Marshall MA, Garmey J, Deroissart J, Prohaska TA, Witztum JL, Binder CJ, Holodick NE, Rothstein TL, McNamara CA. PMID: 35935999; PMCID: PMC9353528.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    16. Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs. Elife. 2022 01 20; 11. Shen Z, Li RZ, Prohaska TA, Hoeksema MA, Spann NJ, Tao J, Fonseca GJ, Le T, Stolze LK, Sakai M, Romanoski CE, Glass CK. PMID: 35049498; PMCID: PMC8809895.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Lifetime mobility of an Arctic woolly mammoth. Science. 2021 08 13; 373(6556):806-808. Wooller MJ, Bataille C, Druckenmiller P, Erickson GM, Groves P, Haubenstock N, Howe T, Irrgeher J, Mann D, Moon K, Potter BA, Prohaska T, Rasic J, Reuther J, Shapiro B, Spaleta KJ, Willis AD. PMID: 34385399.
      View in: PubMed   Mentions: 15     Fields:    
    18. Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans. Sci Rep. 2021 07 20; 11(1):14796. Samekova K, Firbas C, Irrgeher J, Opper C, Prohaska T, Retzmann A, Tschegg C, Meisslitzer C, Tchaikovsky A, Gouya G, Freissmuth M, Wolzt M. PMID: 34285282; PMCID: PMC8292361.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    19. Beethoven's death-the result of medical malpractice? Wien Med Wochenschr. 2021 Nov; 171(15-16):356-362. Reiter C, Prohaska T. PMID: 33765204; PMCID: PMC8553724.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. Ancient DNA reveals monozygotic newborn twins from the Upper Palaeolithic. Commun Biol. 2020 11 06; 3(1):650. Teschler-Nicola M, Fernandes D, Händel M, Einwögerer T, Simon U, Neugebauer-Maresch C, Tangl S, Heimel P, Dobsak T, Retzmann A, Prohaska T, Irrgeher J, Kennett DJ, Olalde I, Reich D, Pinhasi R. PMID: 33159107; PMCID: PMC7648643.
      View in: PubMed   Mentions: 12  Translation:Humans
    21. Multivariate modelling techniques applied to metabolomic, elemental and isotopic fingerprints for the verification of regional geographical origin of Austrian carrots. Food Chem. 2021 Feb 15; 338:127924. Jandric Z, Tchaikovsky A, Zitek A, Causon T, Stursa V, Prohaska T, Hann S. PMID: 32932079.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    22. Consensus statement: loneliness in older adults, the 21st century social determinant of health? BMJ Open. 2020 08 11; 10(8):e034967. Prohaska T, Burholt V, Burns A, Golden J, Hawkley L, Lawlor B, Leavey G, Lubben J, O'Sullivan R, Perissinotto C, van Tilburg T, Tully M, Victor C, Fried L. PMID: 32788184; PMCID: PMC7422633.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    23. A unified approach to loneliness. Lancet. 2020 01 11; 395(10218):114. Fried L, Prohaska T, Burholt V, Burns A, Golden J, Hawkley L, Lawlor B, Leavey G, Lubben J, O'Sullivan R, Perissinotto C, van Tilburg T, Tully M, Victor C. PMID: 31929010.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    24. Fungicide application increased copper-bioavailability and impaired nitrogen fixation through reduced root nodule formation on alfalfa. Ecotoxicology. 2019 Aug; 28(6):599-611. Schneider M, Keiblinger KM, Paumann M, Soja G, Mentler A, Golestani-Fard A, Retzmann A, Prohaska T, Zechmeister-Boltenstern S, Wenzel W, Zehetner F. PMID: 31140046; PMCID: PMC6647429.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    25. A combined chemical imaging approach using (MC) LA-ICP-MS and NIR-HSI to evaluate the diagenetic status of bone material for Sr isotope analysis. Anal Bioanal Chem. 2019 Jan; 411(3):565-580. Retzmann A, Blanz M, Zitek A, Irrgeher J, Feldmann J, Teschler-Nicola M, Prohaska T. PMID: 30511253.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    26. The disastrous copper. Comparing extraction and chelation treatments to face the threat of copper-containing inks on cellulose. Carbohydr Polym. 2019 Feb 15; 206:198-209. Zaccaron S, Potthast A, Henniges U, Draxler J, Prohaska T, McGuiggan P. PMID: 30553313.
      View in: PubMed   Mentions:    Fields:    
    27. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.
      View in: PubMed   Mentions: 2     Fields:    
    28. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409; PMCID: PMC6033669.
      View in: PubMed   Mentions: 256     Fields:    Translation:AnimalsCells
    29. Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies. J Immunol. 2018 03 01; 200(5):1702-1717. Prohaska TA, Que X, Diehl CJ, Hendrikx S, Chang MW, Jepsen K, Glass CK, Benner C, Witztum JL. PMID: 29378911; PMCID: PMC5821571.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    30. Bone-implant degradation and mechanical response of bone surrounding Mg-alloy implants. J Mech Behav Biomed Mater. 2017 07; 71:307-313. Meischel M, Hörmann D, Draxler J, Tschegg EK, Eichler J, Prohaska T, Stanzl-Tschegg SE. PMID: 28390303.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    31. The potential of isotopically enriched magnesium to study bone implant degradation in vivo. Acta Biomater. 2017 03 15; 51:526-536. Draxler J, Martinelli E, Weinberg AM, Zitek A, Irrgeher J, Meischel M, Stanzl-Tschegg SE, Mingler B, Prohaska T. PMID: 28111338.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    32. Iron plaque formed under aerobic conditions efficiently immobilizes arsenic in Lupinus albus L roots. Environ Pollut. 2016 Sep; 216:215-222. Fresno T, Peñalosa JM, Santner J, Puschenreiter M, Prohaska T, Moreno-Jiménez E. PMID: 27263113.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsPHPublic Health
    33. Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol. 2016 Apr; 36(4):682-91. Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum JL, McNamara CA. PMID: 26868208; PMCID: PMC4808436.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    34. Application of non-traditional stable isotopes in analytical ecogeochemistry assessed by MC ICP-MS--A critical review. Anal Bioanal Chem. 2016 Jan; 408(2):369-85. Irrgeher J, Prohaska T. PMID: 26446900.
      View in: PubMed   Mentions: 7     Fields:    
    35. Applications of isotopes in analytical ecogeochemistry. Anal Bioanal Chem. 2016 Jan; 408(2):341-3. Zitek A, Irrgeher J, Prohaska T. PMID: 26446901.
      View in: PubMed   Mentions:    Fields:    
    36. B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. Circ Res. 2015 Jul 17; 117(3):e28-39. Rosenfeld SM, Perry HM, Gonen A, Prohaska TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM, Tsimikas S, Bender TP, Witztum JL, McNamara CA. PMID: 26082558; PMCID: PMC4527334.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    37. Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. J Lipid Res. 2015 Feb; 56(2):440-8. Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum JL, Lang IM, Binder CJ. PMID: 25525116; PMCID: PMC4306697.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    38. Interaction of protein C inhibitor with the type II transmembrane serine protease enteropeptidase. PLoS One. 2012; 7(6):e39262. Prohaska TA, Wahlmüller FC, Furtmüller M, Geiger M. PMID: 22723979; PMCID: PMC3378520.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
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