Thomas Prohaska

Title(s)	Associate Physician, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression. Immunity. 2025 Apr 08; 58(4):826-842.e8. Cobo I, Murillo-Saich J, Alishala M, Calderon S, Coras R, Hemming B, Inkum F, Rosas F, Takei R, Spann N, Prohaska TA, Alabarse PVG, Jeong SJ, Nickl CK, Cheng A, Li B, Vogel A, Weichhart T, Fuster JJ, Le T, Bradstreet TR, Webber AM, Edelson BT, Razani B, Ebert BL, Taneja R, Terkeltaub R, Bryan RL, Guma M, Glass CK. PMID: 40118070.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Olezarsen in patients with hypertriglyceridemia at high cardiovascular risk: Rationale and design of the Essence-TIMI 73b trial. Am Heart J. 2025 Aug; 286:116-124. Bergmark BA, Marston NA, Prohaska TA, Alexander VJ, Zimerman A, Moura FA, Kang YM, Murphy SA, Zhang S, Lu MT, Karwatowska-Prokopczuk E, Tsimikas S, Giugliano RP, Sabatine MS. PMID: 40081744; PMCID: PMC12065083.

View in: PubMed Mentions: Fields:
Car Cardiology
Translation:Humans CTClinical Trials
Design and rationale of the CORE-TIMI 72a and CORE2-TIMI 72b trials of olezarsen in patients with severe hypertriglyceridemia. Am Heart J. 2025 Aug; 286:125-135. Marston NA, Bergmark BA, Alexander VJ, Karwatowska-Prokopczuk E, Kang YM, Moura FA, Prohaska TA, Zimerman A, Zhang S, Murphy SA, Tsimikas S, Giugliano RP, Sabatine MS. PMID: 40064331; PMCID: PMC12065585.

View in: PubMed Mentions: Fields:
Car Cardiology
Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome. N Engl J Med. 2024 05 16; 390(19):1781-1792. Stroes ESG, Alexander VJ, Karwatowska-Prokopczuk E, Hegele RA, Arca M, Ballantyne CM, Soran H, Prohaska TA, Xia S, Ginsberg HN, Witztum JL, Tsimikas S, Balance Investigators. PMID: 38587247.

View in: PubMed Mentions: 27 Fields:
Med Medicine (General)
Translation:Humans CTClinical Trials
Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk. N Engl J Med. 2024 05 16; 390(19):1770-1780. Bergmark BA, Marston NA, Prohaska TA, Alexander VJ, Zimerman A, Moura FA, Murphy SA, Goodrich EL, Zhang S, Gaudet D, Karwatowska-Prokopczuk E, Tsimikas S, Giugliano RP, Sabatine MS, Bridge–TIMI 73a Investigators. PMID: 38587249.

View in: PubMed Mentions: 30 Fields:
Med Medicine (General)
Translation:Humans CTClinical Trials
Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia. N Engl J Med. 2024 Feb 01; 390(5):476-477. Alexander VJ, Karwatowska-Prokopczuk E, Prohaska TA, Li L, Geary RS, Gouni-Berthold I, Oral EA, Hegele RA, Stroes ESG, Witztum JL, Tsimikas S. PMID: 38294982.

View in: PubMed Mentions: 9 Fields:
Med Medicine (General)
Translation:Humans
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression. Mol Cell. 2023 10 05; 83(19):3421-3437.e11. Abe Y, Kofman ER, Almeida M, Ouyang Z, Ponte F, Mueller JR, Cruz-Becerra G, Sakai M, Prohaska TA, Spann NJ, Resende-Coelho A, Seidman JS, Stender JD, Taylor H, Fan W, Link VM, Cobo I, Schlachetzki JCM, Hamakubo T, Jepsen K, Sakai J, Downes M, Evans RM, Yeo GW, Kadonaga JT, Manolagas SC, Rosenfeld MG, Glass CK. PMID: 37751740; PMCID: PMC10591845.

View in: PubMed Mentions: 7 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia. J Clin Lipidol. 2023 May-Jun; 17(3):406-411. Prohaska TA, Alexander VJ, Karwatowska-Prokopczuk E, Tami J, Xia S, Witztum JL, Tsimikas S. PMID: 37164837.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry Met Metabolism
Translation:Humans
B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis. Front Immunol. 2022; 13:909475. Srikakulapu P, Pattarabanjird T, Upadhye A, Bontha SV, Osinski V, Marshall MA, Garmey J, Deroissart J, Prohaska TA, Witztum JL, Binder CJ, Holodick NE, Rothstein TL, McNamara CA. PMID: 35935999; PMCID: PMC9353528.

View in: PubMed Mentions: 6 Fields:
All Allergy and Immunology
Translation:Humans Animals
Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs. Elife. 2022 01 20; 11. Shen Z, Li RZ, Prohaska TA, Hoeksema MA, Spann NJ, Tao J, Fonseca GJ, Le T, Stolze LK, Sakai M, Romanoski CE, Glass CK. PMID: 35049498; PMCID: PMC8809895.

View in: PubMed Mentions: 8 Fields:
Bio Biology
Translation:Humans Animals Cells
Beethoven's death-the result of medical malpractice? Wien Med Wochenschr. 2021 Nov; 171(15-16):356-362. Reiter C, Prohaska T. PMID: 33765204; PMCID: PMC8553724.

View in: PubMed Mentions: 6 Fields:
Med Medicine (General)
Translation:Humans
Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.

View in: PubMed Mentions: 2 Fields:
Sci Science
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409; PMCID: PMC6033669.

View in: PubMed Mentions: 199 Fields:
Sci Science
Translation:Animals Cells
Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies. J Immunol. 2018 03 01; 200(5):1702-1717. Prohaska TA, Que X, Diehl CJ, Hendrikx S, Chang MW, Jepsen K, Glass CK, Benner C, Witztum JL. PMID: 29378911; PMCID: PMC5821571.

View in: PubMed Mentions: 26 Fields:
All Allergy and Immunology
Translation:Animals Cells
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol. 2016 Apr; 36(4):682-91. Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum JL, McNamara CA. PMID: 26868208; PMCID: PMC4808436.

View in: PubMed Mentions: 48 Fields:
Vas Vascular Diseases
Translation:Humans Animals Cells
Application of non-traditional stable isotopes in analytical ecogeochemistry assessed by MC ICP-MS--A critical review. Anal Bioanal Chem. 2016 Jan; 408(2):369-85. Irrgeher J, Prohaska T. PMID: 26446900.

View in: PubMed Mentions: 7 Fields:
Che Chemistry Techniques
Applications of isotopes in analytical ecogeochemistry. Anal Bioanal Chem. 2016 Jan; 408(2):341-3. Zitek A, Irrgeher J, Prohaska T. PMID: 26446901.

View in: PubMed Mentions: Fields:
Che Chemistry Techniques
B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. Circ Res. 2015 Jul 17; 117(3):e28-39. Rosenfeld SM, Perry HM, Gonen A, Prohaska TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM, Tsimikas S, Bender TP, Witztum JL, McNamara CA. PMID: 26082558; PMCID: PMC4527334.

View in: PubMed Mentions: 61 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Animals Cells
Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. J Lipid Res. 2015 Feb; 56(2):440-8. Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum JL, Lang IM, Binder CJ. PMID: 25525116; PMCID: PMC4306697.

View in: PubMed Mentions: 48 Fields:
Bio Biochemistry
Translation:Humans Cells
Interaction of protein C inhibitor with the type II transmembrane serine protease enteropeptidase. PLoS One. 2012; 7(6):e39262. Prohaska TA, Wahlmüller FC, Furtmüller M, Geiger M. PMID: 22723979; PMCID: PMC3378520.

View in: PubMed Mentions: 5 Fields:
Med Medicine (General)Sci Science