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Gerry Boss

TitleTeacher
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0652
La Jolla CA 92093
Phone858-534-8805
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    Collapse Research 
    Collapse Research Activities and Funding
    Sodium Tetrathionate as a Cyanide Antidote
    NIH/NINDS U01NS105057Sep 1, 2017 - May 31, 2020
    Role: Principal Investigator
    Development of antidotes for toxic gases
    NIH U54ES027698Sep 30, 2016 - Aug 31, 2021
    Role: Co-Investigator
    Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide Antidote
    NIH/NINDS U01NS087964Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    A Discovery and Development Pipeline for Cyanide Countermeasures
    NIH U54NS079201Sep 30, 2012 - Aug 31, 2017
    Role: Co-Investigator
    Blood Donor Drives & High School Students to Educate People About Organ Donation
    NIH/NIDDK R01DK098780Sep 30, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
    NIH/NINDS R21NS072105Sep 26, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Combined Use of Cobinamide and a 3-Mercaptopyruvate Prodrug for Cyanide Poisoning
    NIH U54NS063718Sep 30, 2008 - May 31, 2012
    Role: Co-Investigator
    Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying Agent
    NIH/NINDS U01NS058030Sep 27, 2006 - Aug 31, 2017
    Role: Principal Investigator
    Pre-Clinical Studies of the NO Scavenger Cobinamide
    NIH/NIAID R21AI064368Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Educating High School Students and Their Families about Clinical Research (Phase
    NIH/NCRR R25RR022714Sep 23, 2005 - Jul 31, 2012
    Role: Principal Investigator
    Analysis of Ras and Rho Activation in Prostate Cancer
    NIH/NCI R01CA090932Feb 1, 2002 - Jan 31, 2007
    Role: Principal Investigator
    AUTOMATED MEASUREMENT OF RAS &RHO ACTIVATION IN CANCER
    NIH/NCI R33CA089828Feb 1, 2001 - Jan 31, 2005
    Role: Principal Investigator
    Physician-Scientist Research Training Program
    NIH/NIDDK T32DK069263Sep 1, 1999 - Jun 30, 2016
    Role: Principal Investigator
    GENERALIST PHYSICIAN-SCIENTIST TRAINING PROGRAM
    NIH/NCI T32CA081211May 5, 1999 - Jun 30, 2005
    Role: Principal Investigator
    MEASUREMENT OF RAS ACTIVATION IN LUNG CANCER
    NIH/NCI R21CA081115Apr 1, 1999 - Mar 31, 2001
    Role: Principal Investigator
    PUBLIC HEALTH ORGANIZATION AT MORSE &HELIX HS-PHASE II
    NIH/NCRR R25RR012389Jul 10, 1998 - Jun 30, 2005
    Role: Principal Investigator
    DEVELOPMENT OF AN AUTOMATED RAS MEASUREMENT DEVICE
    NIH/NCI R21CA076968Sep 30, 1997 - Mar 31, 2001
    Role: Principal Investigator
    RAS-RELATED PROTEIN IN DIFFERENTIATING MEL CELLS
    NIH/NIGMS R01GM049360May 1, 1993 - Apr 30, 1997
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018; 13(6):e0193889. PMID: 29879736.
      View in: PubMed
    2. Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Ann N Y Acad Sci. 2017 11; 1408(1):61-78. PMID: 29239480.
      View in: PubMed
    3. Greenawald LA, Boss GR, Snyder JL, Reeder A, Bell S. Development of an Inexpensive RGB Color Sensor for the Detection of Hydrogen Cyanide Gas. ACS Sens. 2017 Oct 27; 2(10):1458-1466. PMID: 28967741.
      View in: PubMed
    4. Bebarta VS, Garrett N, Brenner M, Mahon SB, Maddry JK, Boudreau S, Castaneda M, Boss GR. Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model. Acad Emerg Med. 2017 Sep; 24(9):1088-1098. PMID: 28472554.
      View in: PubMed
    5. Brenner M, Azer SM, Oh KJ, Han CH, Lee J, Mahon SB, Du X, Mukai D, Burney T, Saidian M, Chan A, Straker DI, Bebarta VS, Boss GR. Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion. J Clin Toxicol. 2017 Jun; 7(3). PMID: 28868209.
      View in: PubMed
    6. Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol. 2017 May 18; 24(5):565-575.e4. PMID: 28416275.
      View in: PubMed
    7. Tsai CS, Mao RW, Tsai SC, Shahverdi K, Zhu Y, Lin SK, Hsu YH, Boss G, Brenner M, Mahon S, Smaldone GC. Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications. Micromachines (Basel). 2017; 8(2). PMID: 29250438.
      View in: PubMed
    8. Bebarta VS, Brittain M, Chan A, Garrett N, Yoon D, Burney T, Mukai D, Babin M, Pilz RB, Mahon SB, Brenner M, Boss GR. Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. Ann Emerg Med. 2017 Jun; 69(6):718-725.e4. PMID: 28041825.
      View in: PubMed
    9. Sahu D, Gupta S, Hau AM, Nakashima K, Leivo MZ, Searles SC, Elson P, Bomalaski JS, Casteel DE, Boss GR, Hansel DE. Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2a Activity and Is Targetable by Pegylated Arginine Deiminase. Am J Pathol. 2016 Dec 09. PMID: 27979310.
      View in: PubMed
    10. Lee J, Mahon SB, Mukai D, Burney T, Katebian BS, Chan A, Bebarta VS, Yoon D, Boss GR, Brenner M. The Vitamin B12 Analog Cobinamide Is an Effective Antidote for Oral Cyanide Poisoning. J Med Toxicol. 2016 Dec; 12(4):370-379. PMID: 27631586.
      View in: PubMed
    11. Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel DE, Pilz RB. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. J Bone Miner Res. 2017 Jan; 32(1):46-59. PMID: 27391172.
      View in: PubMed
    12. MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT. A countermeasure development pipeline. Ann N Y Acad Sci. 2016 08; 1378(1):58-67. PMID: 27737495.
      View in: PubMed
    13. Greenawald LA, Boss GR, Reeder A, Bell S. Development of a Hydrogen Sulfide End-of-Service-Life Indicator for Respirator Cartridges Using Cobinamide. Sens Actuators B Chem. 2016 Jul; 230:658-666. PMID: 27022206.
      View in: PubMed
    14. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. PMID: 26815411; PMCID: PMC4963240.
    15. Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016 Feb 15; 6:20831. PMID: 26877209; PMCID: PMC4753484.
    16. Greenawald LA, Snyder JL, Fry NL, Sailor MJ, Boss GR, Finklea HO, Bell S. Development of a cobinamide-based end-of-service-life indicator for detection of hydrogen cyanide gas. Sens Actuators B Chem. 2015 Dec 31; 221:379-385. PMID: 26213448.
      View in: PubMed
    17. Stutelberg MW, Dzisam JK, Monteil AR, Petrikovics I, Boss GR, Patterson SE, Rockwood GA, Logue BA. Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 01; 1008:181-188. PMID: 26655110.
      View in: PubMed
    18. Wassenaar JW, Boss GR, Christman KL. Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials. 2015 Sep; 64:108-14. PMID: 26125502; PMCID: PMC4506649.
    19. Kadjo AF, Dasgupta PK, Boss GR. Comment on "Rapid visual detection of blood cyanide" by C. Männel-Croisé and F. Zelder, Analytical Methods, 2012, 4, 2632. Anal Methods. 2015; 7(13):5707-5711. PMID: 26640525.
      View in: PubMed
    20. Spitler R, Ho H, Norpetlian F, Kong X, Jiang J, Yokomori K, Andersen B, Boss GR, Berns MW. Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing. J Biomed Opt. 2015 May; 20(5):051022. PMID: 25562608; PMCID: PMC4284311.
    21. Chan A, Jiang J, Fridman A, Guo LT, Shelton GD, Liu MT, Green C, Haushalter KJ, Patel HH, Lee J, Yoon D, Burney T, Mukai D, Mahon SB, Brenner M, Pilz RB, Boss GR. Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection. J Med Chem. 2015 Feb 26; 58(4):1750-9. PMID: 25650735; PMCID: PMC4494098.
    22. Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR. In reply. Ann Emerg Med. 2015 Feb; 65(2):235. PMID: 25601262.
      View in: PubMed
    23. Joshua J, Schwaerzer GK, Kalyanaraman H, Cory E, Sah RL, Li M, Vaida F, Boss GR, Pilz RB. Soluble guanylate cyclase as a novel treatment target for osteoporosis. Endocrinology. 2014 Dec; 155(12):4720-30. PMID: 25188528; PMCID: PMC4239425.
    24. Salnikov DS, Makarov SV, van Eldik R, Kucherenko PN, Boss GR. Kinetics and mechanism of the reaction of hydrogen sulfide with diaquacobinamide in aqueous solution. Eur J Inorg Chem. 2014 Sep; 2014(25):4123-4133. PMID: 25580081.
      View in: PubMed
    25. Saha A, Connelly S, Jiang J, Zhuang S, Amador DT, Phan T, Pilz RB, Boss GR. Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis. Mol Cell. 2014 Jul 17; 55(2):264-76. PMID: 24981175; PMCID: PMC4104231.
    26. Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel DE, Frangos JA, Dillmann W, Boss GR, Pilz RB. Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor. Sci Signal. 2014 May 20; 7(326):ra48. PMID: 24847117.
      View in: PubMed
    27. Lee J, Kim JG, Mahon SB, Mukai D, Yoon D, Boss GR, Patterson SE, Rockwood G, Isom G, Brenner M. Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy. J Biomed Opt. 2014 May; 19(5):055001. PMID: 24788369; PMCID: PMC4006145.
    28. Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR. Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model. Ann Emerg Med. 2014 Dec; 64(6):612-9. PMID: 24746273; PMCID: PMC4487531.
    29. Fry NL, Boss GR, Sailor MJ. Oxidation-Induced Trapping of Drugs in Porous Silicon Microparticles. Chem Mater. 2014 Apr 22; 26(8):2758-2764. PMID: 25678746.
      View in: PubMed
    30. Dereven'kov IA, Salnikov DS, Makarov SV, Boss GR, Koifman OI. Kinetics and mechanism of oxidation of super-reduced cobalamin and cobinamide species by thiosulfate, sulfite and dithionite. Dalton Trans. 2013 Nov 21; 42(43):15307-16. PMID: 23999614; PMCID: PMC3813607.
    31. Fridman A, Saha A, Chan A, Casteel DE, Pilz RB, Boss GR. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. Biochem J. 2013 Aug 15; 454(1):91-9. PMID: 23734909.
      View in: PubMed
    32. Spitler R, Schwappacher R, Wu T, Kong X, Yokomori K, Pilz RB, Boss GR, Berns MW. Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase. Cell Signal. 2013 Dec; 25(12):2374-82. PMID: 23920342.
      View in: PubMed
    33. Mitchell BL, Bhandari RK, Bebarta VS, Rockwood GA, Boss GR, Logue BA. Toxicokinetic profiles of a-ketoglutarate cyanohydrin, a cyanide detoxification product, following exposure to potassium cyanide. Toxicol Lett. 2013 Sep 12; 222(1):83-9. PMID: 23867915.
      View in: PubMed
    34. Swezey R, Shinn W, Green C, Drover DR, Hammer GB, Schulman SR, Zajicek A, Jett DA, Boss GR. Comparison of a new cobinamide-based method to a standard laboratory method for measuring cyanide in human blood. J Anal Toxicol. 2013 Jul-Aug; 37(6):382-5. PMID: 23653045; PMCID: PMC3708715.
    35. Dereven'kov IA, Salnikov DS, Makarov SV, Surducan M, Silaghi-Dumitrescu R, Boss GR. Comparative study of reaction of cobalamin and cobinamide with thiocyanate. J Inorg Biochem. 2013 Aug; 125:32-9. PMID: 23685470.
      View in: PubMed
    36. Schwappacher R, Kilic A, Kojonazarov B, Lang M, Diep T, Zhuang S, Gawlowski T, Schermuly RT, Pfeifer A, Boss GR, Pilz RB. A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension. J Biol Chem. 2013 Jun 07; 288(23):16557-66. PMID: 23612967; PMCID: PMC3675591.
    37. Boss GR. ACP Journal Club: allopurinol during acute gout attacks did not differ from delayed allopurinol for pain or recurrence. Ann Intern Med. 2013 Apr 16; 158(8):JC6. PMID: 23588771.
      View in: PubMed
    38. Tian Y, Dasgupta PK, Mahon SB, Ma J, Brenner M, Wang JH, Boss GR. A disposable blood cyanide sensor. Anal Chim Acta. 2013 Mar 20; 768:129-35. PMID: 23473259; PMCID: PMC3596829.
    39. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. PMID: 23345455; PMCID: PMC3633825.
    40. Kim JG, Lee J, Mahon SB, Mukai D, Patterson SE, Boss GR, Tromberg BJ, Brenner M. Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism. J Biomed Opt. 2012 Oct; 17(10):105005. PMID: 23223999; PMCID: PMC3603151.
    41. Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J Biol Chem. 2012 Nov 02; 287(45):38367-78. PMID: 22992742; PMCID: PMC3488105.
    42. Ma J, Dasgupta PK, Zelder FH, Boss GR. Cobinamide chemistries for photometric cyanide determination. A merging zone liquid core waveguide cyanide analyzer using cyanoaquacobinamide. Anal Chim Acta. 2012 Jul 29; 736:78-84. PMID: 22769008; PMCID: PMC3392611.
    43. Rangaswami H, Schwappacher R, Tran T, Chan GC, Zhuang S, Boss GR, Pilz RB. Protein kinase G and focal adhesion kinase converge on Src/Akt/ß-catenin signaling module in osteoblast mechanotransduction. J Biol Chem. 2012 Jun 15; 287(25):21509-19. PMID: 22563076; PMCID: PMC3375572.
    44. Marathe N, Rangaswami H, Zhuang S, Boss GR, Pilz RB. Pro-survival effects of 17ß-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II. J Biol Chem. 2012 Jan 06; 287(2):978-88. PMID: 22117068; PMCID: PMC3256896.
    45. Salnikov DS, Silaghi-Dumitrescu R, Makarov SV, van Eldik R, Boss GR. Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(II) complex. Dalton Trans. 2011 Oct 14; 40(38):9831-4. PMID: 21879074.
      View in: PubMed
    46. Chan A, Crankshaw DL, Monteil A, Patterson SE, Nagasawa HT, Briggs JE, Kozocas JA, Mahon SB, Brenner M, Pilz RB, Bigby TD, Boss GR. The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning. Clin Toxicol (Phila). 2011 Jun; 49(5):366-73. PMID: 21740135; PMCID: PMC3882312.
    47. Ma J, Ohira S, Mishra SK, Puanngam M, Dasgupta PK, Mahon SB, Brenner M, Blackledge W, Boss GR. Rapid point of care analyzer for the measurement of cyanide in blood. Anal Chem. 2011 Jun 01; 83(11):4319-24. PMID: 21553921; PMCID: PMC3105183.
    48. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. PMID: 21177494; PMCID: PMC3093297.
    49. Brenner M, Kim JG, Lee J, Mahon SB, Lemor D, Ahdout R, Boss GR, Blackledge W, Jann L, Nagasawa HT, Patterson SE. Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity. Toxicol Appl Pharmacol. 2010 Nov 01; 248(3):269-76. PMID: 20705081; PMCID: PMC3382974.
    50. Chan A, Balasubramanian M, Blackledge W, Mohammad OM, Alvarez L, Boss GR, Bigby TD. Cobinamide is superior to other treatments in a mouse model of cyanide poisoning. Clin Toxicol (Phila). 2010 Aug; 48(7):709-17. PMID: 20704457; PMCID: PMC3119202.
    51. Ma J, Dasgupta PK, Blackledge W, Boss GR. Cobinamide-based cyanide analysis by multiwavelength spectrometry in a liquid core waveguide. Anal Chem. 2010 Jul 15; 82(14):6244-50. PMID: 20560532; PMCID: PMC2912415.
    52. Blackledge WC, Blackledge CW, Griesel A, Mahon SB, Brenner M, Pilz RB, Boss GR. New facile method to measure cyanide in blood. Anal Chem. 2010 May 15; 82(10):4216-21. PMID: 20420400; PMCID: PMC2889625.
    53. Ma J, Dasgupta PK, Blackledge W, Boss GR. Temperature dependence of Henry's law constant for hydrogen cyanide. Generation of trace standard gaseous hydrogen cyanide. Environ Sci Technol. 2010 Apr 15; 44(8):3028-34. PMID: 20302333; PMCID: PMC2855313.
    54. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J. 2010 Jun; 24(6):2056-65. PMID: 20097874; PMCID: PMC2874475.
    55. Brenner M, Kim JG, Mahon SB, Lee J, Kreuter KA, Blackledge W, Mukai D, Patterson S, Mohammad O, Sharma VS, Boss GR. Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicity. Ann Emerg Med. 2010 Apr; 55(4):352-63. PMID: 20045579; PMCID: PMC2963429.
    56. Brenner M, Mahon SB, Lee J, Kim J, Mukai D, Goodman S, Kreuter KA, Ahdout R, Mohammad O, Sharma VS, Blackledge W, Boss GR. Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring. J Biomed Opt. 2010 Jan-Feb; 15(1):017001. PMID: 20210475; PMCID: PMC2816993.
    57. Rangaswami H, Marathe N, Zhuang S, Chen Y, Yeh JC, Frangos JA, Boss GR, Pilz RB. Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J Biol Chem. 2009 May 29; 284(22):14796-808. PMID: 19282289; PMCID: PMC2685661.
    58. Casteel DE, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem. 2009 Feb 27; 284(9):5807-18. PMID: 19119139; PMCID: PMC2645831.
    59. Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J Biol Chem. 2009 Feb 06; 284(6):3521-8. PMID: 19068483; PMCID: PMC2635033.
    60. Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J Infect Dis. 2008 Feb 01; 197(3):457-64. PMID: 18199034.
      View in: PubMed
    61. Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, Boss GR. Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp Biol Med (Maywood). 2007 Dec; 232(11):1432-40. PMID: 18040067.
      View in: PubMed
    62. Boss GR. Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis. Evid Based Med. 2007 Dec; 12(6):175. PMID: 18063735.
      View in: PubMed
    63. Zhang T, Zhuang S, Casteel DE, Looney DJ, Boss GR, Pilz RB. A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase. J Biol Chem. 2007 Nov 16; 282(46):33367-80. PMID: 17878170.
      View in: PubMed
    64. Turner SJ, Zhuang S, Zhang T, Boss GR, Pilz RB. Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol. 2008 Jan 15; 75(2):405-13. PMID: 17920041; PMCID: PMC2228324.
    65. Scheele JS, Marks RE, Boss GR. Signaling by small GTPases in the immune system. Immunol Rev. 2007 Aug; 218:92-101. PMID: 17624946.
      View in: PubMed
    66. Broderick KE, Balasubramanian M, Chan A, Potluri P, Feala J, Belke DD, McCulloch A, Sharma VS, Pilz RB, Bigby TD, Boss GR. The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide. Exp Biol Med (Maywood). 2007 Jun; 232(6):789-98. PMID: 17526771.
      View in: PubMed
    67. Broderick KE, Zhang T, Rangaswami H, Zeng Y, Zhao X, Boss GR, Pilz RB. Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Mol Endocrinol. 2007 May; 21(5):1148-62. PMID: 17341596.
      View in: PubMed
    68. Broderick KE, Feala J, McCulloch A, Paternostro G, Sharma VS, Pilz RB, Boss GR. The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis. FASEB J. 2006 Sep; 20(11):1865-73. PMID: 16940158.
      View in: PubMed
    69. Cohen G, Mustafi R, Chumsangsri A, Little N, Nathanson J, Cerda S, Jagadeeswaran S, Dougherty U, Joseph L, Hart J, Yerian L, Tretiakova M, Yuan W, Obara P, Khare S, Sinicrope FA, Fichera A, Boss GR, Carroll R, Bissonnette M. Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. Cancer Res. 2006 Jun 01; 66(11):5656-64. PMID: 16740703.
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    70. Satriano J, Wead L, Cardus A, Deng A, Boss GR, Thomson SC, Blantz RC. Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation. Am J Physiol Renal Physiol. 2006 Nov; 291(5):F1078-82. PMID: 16705150.
      View in: PubMed
    71. Broderick KE, Potluri P, Zhuang S, Scheffler IE, Sharma VS, Pilz RB, Boss GR. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood). 2006 May; 231(5):641-9. PMID: 16636313.
      View in: PubMed
    72. Zeng Y, Zhuang S, Gloddek J, Tseng CC, Boss GR, Pilz RB. Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4. J Biol Chem. 2006 Jun 23; 281(25):16951-61. PMID: 16632465.
      View in: PubMed
    73. Casteel DE, Boss GR, Pilz RB. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. J Biol Chem. 2005 Nov 18; 280(46):38211-8. PMID: 16166082.
      View in: PubMed
    74. Zhao X, Zhuang S, Chen Y, Boss GR, Pilz RB. Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3. J Biol Chem. 2005 Sep 23; 280(38):32683-92. PMID: 16055922.
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    75. Kambo A, Sharma VS, Casteel DE, Woods VL, Pilz RB, Boss GR. Nitric oxide inhibits mammalian methylmalonyl-CoA mutase. J Biol Chem. 2005 Mar 18; 280(11):10073-82. PMID: 15647267.
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    76. Broderick KE, Singh V, Zhuang S, Kambo A, Chen JC, Sharma VS, Pilz RB, Boss GR. Nitric oxide scavenging by the cobalamin precursor cobinamide. J Biol Chem. 2005 Mar 11; 280(10):8678-85. PMID: 15632180.
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    77. Zhuang S, Nguyen GT, Chen Y, Gudi T, Eigenthaler M, Jarchau T, Walter U, Boss GR, Pilz RB. Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation. J Biol Chem. 2004 Mar 12; 279(11):10397-407. PMID: 14679200.
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    78. Sharma VS, Pilz RB, Boss GR, Magde D. Reactions of nitric oxide with vitamin B12 and its precursor, cobinamide. Biochemistry. 2003 Jul 29; 42(29):8900-8. PMID: 12873151.
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    79. Khare S, Cerda S, Wali RK, von Lintig FC, Tretiakova M, Joseph L, Stoiber D, Cohen G, Nimmagadda K, Hart J, Sitrin MD, Boss GR, Bissonnette M. Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. Cancer Res. 2003 Jul 01; 63(13):3517-23. PMID: 12839936.
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    80. Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB. Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol Cell Biol. 2003 Jun; 23(12):4066-82. PMID: 12773552; PMCID: PMC156132.
    81. Gudi S, Huvar I, White CR, McKnight NL, Dusserre N, Boss GR, Frangos JA. Rapid activation of Ras by fluid flow is mediated by Galpha(q) and Gbetagamma subunits of heterotrimeric G proteins in human endothelial cells. Arterioscler Thromb Vasc Biol. 2003 Jun 01; 23(6):994-1000. PMID: 12714438.
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    82. Lau N, Uhlmann EJ, Von Lintig FC, Nagy A, Boss GR, Gutmann DH, Guha A. Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression. Int J Oncol. 2003 Jan; 22(1):195-200. PMID: 12469204.
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    83. Chen JC, Zhuang S, Nguyen TH, Boss GR, Pilz RB. Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity. J Biol Chem. 2003 Jan 31; 278(5):2807-18. PMID: 12429740.
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    84. Hansen LA, Boss GR. Use of live animals in the curricula of U.S. medical schools: survey results from 2001. Acad Med. 2002 Nov; 77(11):1147-9. PMID: 12431930.
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    85. Im E, von Lintig FC, Chen J, Zhuang S, Qui W, Chowdhury S, Worley PF, Boss GR, Pilz RB. Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene. 2002 Sep 12; 21(41):6356-65. PMID: 12214276.
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    86. Woods SA, Marmor E, Feldkamp M, Lau N, Apicelli AJ, Boss G, Gutmann DH, Guha A. Aberrant G protein signaling in nervous system tumors. J Neurosurg. 2002 Sep; 97(3):627-42. PMID: 12296648.
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    87. Gudi T, Chen JC, Casteel DE, Seasholtz TM, Boss GR, Pilz RB. cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions. J Biol Chem. 2002 Oct 04; 277(40):37382-93. PMID: 12119292.
      View in: PubMed
    88. Chen JC, von Lintig FC, Jones SB, Huvar I, Boss GR. High-efficiency solid-phase capture using glass beads bonded to microcentrifuge tubes: immunoprecipitation of proteins from cell extracts and assessment of ras activation. Anal Biochem. 2002 Mar 15; 302(2):298-304. PMID: 11878811.
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