Gerard Boss

Title(s)Recall Faculty, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-9758-8714 Additional info
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    Collapse Research 
    Collapse Research Activities and Funding
    Sodium Tetrathionate as a Cyanide Antidote
    NIH/NINDS U01NS105057Sep 1, 2017 - May 31, 2020
    Role: Principal Investigator
    Development of antidotes for toxic gases
    NIH U54ES027698Sep 30, 2016 - Aug 31, 2021
    Role: Co-Investigator
    Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide Antidote
    NIH/NINDS U01NS087964Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    A Discovery and Development Pipeline for Cyanide Countermeasures
    NIH U54NS079201Sep 30, 2012 - Aug 31, 2017
    Role: Co-Investigator
    Blood Donor Drives & High School Students to Educate People About Organ Donation
    NIH/NIDDK R01DK098780Sep 30, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
    NIH/NINDS R21NS072105Sep 26, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Educating High School Students and Their Families about Clinical Research (Phase
    NIH/NCRR R25RR022714Jul 23, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Combined Use of Cobinamide and a 3-Mercaptopyruvate Prodrug for Cyanide Poisoning
    NIH U54NS063718Sep 30, 2008 - May 31, 2012
    Role: Co-Investigator
    Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying Agent
    NIH/NINDS U01NS058030Sep 27, 2006 - May 31, 2011
    Role: Principal Investigator
    Pre-Clinical Studies of the NO Scavenger Cobinamide
    NIH/NIAID R21AI064368Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Analysis of Ras and Rho Activation in Prostate Cancer
    NIH/NCI R01CA090932Feb 1, 2002 - Jan 31, 2007
    Role: Principal Investigator
    AUTOMATED MEASUREMENT OF RAS &RHO ACTIVATION IN CANCER
    NIH/NCI R33CA089828Feb 1, 2001 - Jan 31, 2005
    Role: Principal Investigator
    Physician-Scientist Research Training Program
    NIH/NIDDK T32DK069263Sep 1, 1999 - Jun 30, 2016
    Role: Principal Investigator
    GENERALIST PHYSICIAN-SCIENTIST TRAINING PROGRAM
    NIH/NCI T32CA081211May 5, 1999 - Jun 30, 2005
    Role: Principal Investigator
    MEASUREMENT OF RAS ACTIVATION IN LUNG CANCER
    NIH/NCI R21CA081115Apr 1, 1999 - Mar 31, 2001
    Role: Principal Investigator
    PUBLIC HEALTH ORGANIZATION AT MORSE &HELIX HS-PHASE II
    NIH/NCRR R25RR012389Jul 10, 1998 - Jun 30, 2005
    Role: Principal Investigator
    DEVELOPMENT OF AN AUTOMATED RAS MEASUREMENT DEVICE
    NIH/NCI R21CA076968Sep 30, 1997 - Sep 29, 2000
    Role: Principal Investigator
    RAS-RELATED PROTEIN IN DIFFERENTIATING MEL CELLS
    NIH/NIGMS R01GM049360May 1, 1993 - Apr 30, 1997
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Methyl mercaptan gas: mechanisms of toxicity and demonstration of the effectiveness of cobinamide as an antidote in mice and rabbits. Clin Toxicol (Phila). 2022 May; 60(5):615-622. Philipopoulos GP, Tat J, Chan A, Jiang J, Mukai D, Burney T, Doosty M, Mahon S, Patel HH, White CW, Brenner M, Lee J, Boss GR. PMID: 34989638; PMCID: PMC9662850.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Bladder Cancer Invasion Is Mediated by Mammalian Target of Rapamycin Complex 2-Driven Regulation of Nitric Oxide and Invadopodia Formation. Am J Pathol. 2021 12; 191(12):2203-2218. Sahu D, Huan J, Wang H, Sahoo D, Casteel DE, Klemke RL, Boss GR, Hansel DE. PMID: 34428425.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Development of sodium tetrathionate as a cyanide and methanethiol antidote. Clin Toxicol (Phila). 2022 Mar; 60(3):332-341. Chan A, Lee J, Bhadra S, Bortey-Sam N, Hendry-Hofer TB, Bebarta VS, Mahon SB, Brenner M, Logue B, Pilz RB, Boss GR. PMID: 34328378; PMCID: PMC8800944.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. Br J Pharmacol. 2022 06; 179(11):2413-2429. Schwaerzer GK, Casteel DE, Cividini F, Kalyanaraman H, Zhuang S, Gu Y, Dalton ND, Peterson KL, Dillmann WH, Boss GR, Pilz RB. PMID: 34000062.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Sodium azide poisoning: a narrative review. Clin Toxicol (Phila). 2021 Aug; 59(8):683-697. Tat J, Heskett K, Satomi S, Pilz RB, Golomb BA, Boss GR. PMID: 34128439; PMCID: PMC8349855.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    6. Efficacy of oral administration of sodium thiosulfate in a large, swine model of oral cyanide toxicity. J Med Toxicol. 2021 07; 17(3):257-264. Ng PC, Hendry-Hofer TB, Brenner M, Mahon SB, Boss GR, Maddry JK, Bebarta VS. PMID: 33821433; PMCID: PMC8206226.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Intramuscular cobinamide as an antidote to methyl mercaptan poisoning. Inhal Toxicol. 2021 01; 33(1):25-32. Hendry-Hofer TB, Ng PC, McGrath AM, Soules K, Mukai DS, Chan A, Maddry JK, White CW, Lee J, Mahon SB, Brenner M, Boss GR, Bebarta VS. PMID: 33356664; PMCID: PMC8063453.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    8. Remote Detection of HCN, HF, and Nerve Agent Vapors Based on Self-Referencing, Dye-Impregnated Porous Silicon Photonic Crystals. ACS Sens. 2021 02 26; 6(2):418-428. Lu YS, Vijayakumar S, Chaix A, Pimentel BR, Bentz KC, Li S, Chan A, Wahl C, Ha JS, Hunka DE, Boss GR, Cohen SM, Sailor MJ. PMID: 33263399.
      View in: PubMed   Mentions:    Fields:    
    9. Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity. Sci Rep. 2020 11 16; 10(1):19907. Wahwah N, Dhar D, Chen H, Zhuang S, Chan A, Casteel DE, Kalyanaraman H, Pilz RB, Boss GR. PMID: 33199755; PMCID: PMC7670436.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Assessment of High School Students' Participation in Blood Donation and Registration as an Organ Donor. JAMA Netw Open. 2020 09 01; 3(9):e2016377. Tat J, Hays B, Teachworth M, Kuo A, Pilz RB, Golomb BA, Boss GR. PMID: 32945872; PMCID: PMC7501534.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Intramuscular aminotetrazole cobinamide as a treatment for inhaled hydrogen sulfide poisoning in a large swine model. Ann N Y Acad Sci. 2020 11; 1479(1):159-167. Hendry-Hofer TB, Ng PC, McGrath AM, Mukai D, Brenner M, Mahon S, Maddry JK, Boss GR, Bebarta VS. PMID: 32233102.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    12. Improvement of shared decision making in integrated stroke care: a before and after evaluation using a questionnaire survey. BMC Health Serv Res. 2019 Dec 05; 19(1):936. Voogdt-Pruis HR, Ras T, van der Dussen L, Benjaminsen S, Goossens PH, Raats I, Boss G, van Hoef EFM, Lindhout M, Tjon-A-Tsien MRS, Vrijhoef HJM. PMID: 31805927; PMCID: PMC6896582.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat Commun. 2019 08 06; 10(1):3533. Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB. PMID: 31387997; PMCID: PMC6684604.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Efficacy of Oral Administration of Sodium Thiosulfate and Glycine in a Large, Swine Model of Oral Cyanide Toxicity. Ann Emerg Med. 2019 09; 74(3):423-429. Ng PC, Hendry-Hofer TB, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS. PMID: 31080026.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    15. Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development. J Med Toxicol. 2019 10; 15(4):287-294. Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Haouzi P, Bebarta VS. PMID: 31062177; PMCID: PMC6825067.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    16. Antidotal efficacies of the cyanide antidote candidate dimethyl trisulfide alone and in combination with cobinamide derivatives. Toxicol Mech Methods. 2019 Jul; 29(6):438-444. Petrikovics I, Kiss L, Chou CE, Ebrahimpour A, Kovács K, Kiss M, Logue B, Chan A, Manage ABW, Budai M, Boss GR, Rockwood GA. PMID: 30822191.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    17. Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity. Clin Toxicol (Phila). 2020 01; 58(1):29-35. Hendry-Hofer TB, Witeof AE, Ng PC, Mahon SB, Brenner M, Boss GR, Bebarta VS. PMID: 31008657; PMCID: PMC7521135.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    18. A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges. J Med Toxicol. 2019 Apr; 15(2):128-133. Hendry-Hofer TB, Ng PC, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS. PMID: 30539383; PMCID: PMC6441064.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine. Clin Toxicol (Phila). 2019 03; 57(3):189-196. Ng PC, Hendry-Hofer TB, Garrett N, Brenner M, Mahon SB, Maddry JK, Haouzi P, Boss GR, Gibbons TF, Araña AA, Bebarta VS. PMID: 30430872; PMCID: PMC6540978.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning. FASEB Bioadv. 2019 Feb; 1(2):81-92. Morningstar J, Lee J, Hendry-Hofer T, Witeof A, Lyle LT, Knipp G, MacRae CA, Boss GR, Peterson RT, Davisson VJ, Gerszten RE, Bebarta VS, Mahon S, Brenner M, Nath AK. PMID: 31355359; PMCID: PMC6660183.
      View in: PubMed   Mentions: 4  
    21. Characterization of a Swine (Sus scrofa) Model of Oral Potassium Cyanide Intoxication. Comp Med. 2018 10 01; 68(5):375-379. Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Bebarta VS. PMID: 30208987; PMCID: PMC6200030.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018; 13(6):e0193889. Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. PMID: 29879736; PMCID: PMC5991913.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    23. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Ann N Y Acad Sci. 2017 11; 1408(1):61-78. Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK. PMID: 29239480; PMCID: PMC5734662.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    24. Development of an Inexpensive RGB Color Sensor for the Detection of Hydrogen Cyanide Gas. ACS Sens. 2017 10 27; 2(10):1458-1466. Greenawald LA, Boss GR, Snyder JL, Reeder A, Bell S. PMID: 28967741.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model. Acad Emerg Med. 2017 09; 24(9):1088-1098. Bebarta VS, Garrett N, Brenner M, Mahon SB, Maddry JK, Boudreau S, Castaneda M, Boss GR. PMID: 28472554.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    26. Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion. J Clin Toxicol. 2017 Jun; 7(3). Brenner M, Azer SM, Oh KJ, Han CH, Lee J, Mahon SB, Du X, Mukai D, Burney T, Saidian M, Chan A, Straker DI, Bebarta VS, Boss GR. PMID: 28868209; PMCID: PMC5578424.
      View in: PubMed   Mentions: 3  
    27. Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol. 2017 May 18; 24(5):565-575.e4. Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. PMID: 28416275; PMCID: PMC5472353.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    28. Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications. Micromachines (Basel). 2017; 8(2). Tsai CS, Mao RW, Tsai SC, Shahverdi K, Zhu Y, Lin SK, Hsu YH, Boss G, Brenner M, Mahon S, Smaldone GC. PMID: 29250438; PMCID: PMC5726552.
      View in: PubMed   Mentions: 2  
    29. Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. Ann Emerg Med. 2017 Jun; 69(6):718-725.e4. Bebarta VS, Brittain M, Chan A, Garrett N, Yoon D, Burney T, Mukai D, Babin M, Pilz RB, Mahon SB, Brenner M, Boss GR. PMID: 28041825; PMCID: PMC5446299.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    30. Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase. Am J Pathol. 2017 01; 187(1):200-213. Sahu D, Gupta S, Hau AM, Nakashima K, Leivo MZ, Searles SC, Elson P, Bomalaski JS, Casteel DE, Boss GR, Hansel DE. PMID: 27979310; PMCID: PMC5225295.
      View in: PubMed   Mentions: 10     Fields:    
    31. The Vitamin B12 Analog Cobinamide Is an Effective Antidote for Oral Cyanide Poisoning. J Med Toxicol. 2016 12; 12(4):370-379. Lee J, Mahon SB, Mukai D, Burney T, Katebian BS, Chan A, Bebarta VS, Yoon D, Boss GR, Brenner M. PMID: 27631586; PMCID: PMC5135677.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. J Bone Miner Res. 2017 01; 32(1):46-59. Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel DE, Pilz RB. PMID: 27391172; PMCID: PMC5199609.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    33. A countermeasure development pipeline. Ann N Y Acad Sci. 2016 08; 1378(1):58-67. MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT. PMID: 27737495; PMCID: PMC6420827.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    34. Development of a Hydrogen Sulfide End-of-Service-Life Indicator for Respirator Cartridges Using Cobinamide. Sens Actuators B Chem. 2016 Jul; 230:658-666. Greenawald LA, Boss GR, Reeder A, Bell S. PMID: 27022206; PMCID: PMC4807636.
      View in: PubMed   Mentions:
    35. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. PMID: 26815411; PMCID: PMC4963240.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    36. Lower sulfurtransferase detoxification rates of cyanide in konzo-A tropical spastic paralysis linked to cassava cyanogenic poisoning. Neurotoxicology. 2017 03; 59:256-262. Kambale KJ, Ali ER, Sadiki NH, Kayembe KP, Mvumbi LG, Yandju DL, Boivin MJ, Boss GR, Stadler DD, Lambert WE, Lasarev MR, Okitundu LA, Mumba Ngoyi D, Banea JP, Tshala-Katumbay DD. PMID: 27246648; PMCID: PMC5125906.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    37. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016 Feb 15; 6:20831. Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. PMID: 26877209; PMCID: PMC4753484.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    38. Development of a cobinamide-based end-of-service-life indicator for detection of hydrogen cyanide gas. Sens Actuators B Chem. 2015 Dec 31; 221:379-385. Greenawald LA, Snyder JL, Fry NL, Sailor MJ, Boss GR, Finklea HO, Bell S. PMID: 26213448; PMCID: PMC4511729.
      View in: PubMed   Mentions: 3  
    39. Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 01; 1008:181-188. Stutelberg MW, Dzisam JK, Monteil AR, Petrikovics I, Boss GR, Patterson SE, Rockwood GA, Logue BA. PMID: 26655110.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    40. Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials. 2015 Sep; 64:108-14. Wassenaar JW, Boss GR, Christman KL. PMID: 26125502; PMCID: PMC4506649.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    41. Comment on "Rapid visual detection of blood cyanide" by C. Männel-Croisé and F. Zelder, Analytical Methods, 2012, 4, 2632. Anal Methods. 2015; 7(13):5707-5711. Kadjo AF, Dasgupta PK, Boss GR. PMID: 26640525; PMCID: PMC4670041.
      View in: PubMed   Mentions: 1     Fields:    
    42. Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities. Nat Commun. 2015 Jun 12; 6:7389. Kollareddy M, Dimitrova E, Vallabhaneni KC, Chan A, Le T, Chauhan KM, Carrero ZI, Ramakrishnan G, Watabe K, Haupt Y, Haupt S, Pochampally R, Boss GR, Romero DG, Radu CG, Martinez LA. PMID: 26067754; PMCID: PMC4467467.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    43. Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing. J Biomed Opt. 2015 May; 20(5):051022. Spitler R, Ho H, Norpetlian F, Kong X, Jiang J, Yokomori K, Andersen B, Boss GR, Berns MW. PMID: 25562608; PMCID: PMC4284311.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    44. Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection. J Med Chem. 2015 Feb 26; 58(4):1750-9. Chan A, Jiang J, Fridman A, Guo LT, Shelton GD, Liu MT, Green C, Haushalter KJ, Patel HH, Lee J, Yoon D, Burney T, Mukai D, Mahon SB, Brenner M, Pilz RB, Boss GR. PMID: 25650735; PMCID: PMC4494098.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    45. In reply. Ann Emerg Med. 2015 Feb; 65(2):235. Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR. PMID: 25601262.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    46. Serum 8,12-iso-iPF2α-VI isoprostane marker of oxidative damage and cognition deficits in children with konzo. PLoS One. 2014; 9(9):e107191. Makila-Mabe BG, Kikandau KJ, Sombo TM, Okitundu DL, Mwanza JC, Boivin MJ, Ngoyi MD, Muyembe JJ, Banea JP, Boss GR, Tshala-Katumbay D. PMID: 25222616; PMCID: PMC4164531.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    47. Soluble guanylate cyclase as a novel treatment target for osteoporosis. Endocrinology. 2014 Dec; 155(12):4720-30. Joshua J, Schwaerzer GK, Kalyanaraman H, Cory E, Sah RL, Li M, Vaida F, Boss GR, Pilz RB. PMID: 25188528; PMCID: PMC4239425.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    48. Kinetics and mechanism of the reaction of hydrogen sulfide with diaquacobinamide in aqueous solution. Eur J Inorg Chem. 2014 Sep; 2014(25):4123-4133. Salnikov DS, Makarov SV, van Eldik R, Kucherenko PN, Boss GR. PMID: 25580081; PMCID: PMC4286256.
      View in: PubMed   Mentions: 11  
    49. Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis. Mol Cell. 2014 Jul 17; 55(2):264-76. Saha A, Connelly S, Jiang J, Zhuang S, Amador DT, Phan T, Pilz RB, Boss GR. PMID: 24981175; PMCID: PMC4104231.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    50. Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor. Sci Signal. 2014 May 20; 7(326):ra48. Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel DE, Frangos JA, Dillmann W, Boss GR, Pilz RB. PMID: 24847117; PMCID: PMC6504257.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    51. Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy. J Biomed Opt. 2014 May; 19(5):055001. Lee J, Kim JG, Mahon SB, Mukai D, Yoon D, Boss GR, Patterson SE, Rockwood G, Isom G, Brenner M. PMID: 24788369; PMCID: PMC4006145.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    52. Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model. Ann Emerg Med. 2014 Dec; 64(6):612-9. Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR. PMID: 24746273; PMCID: PMC4487531.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    53. The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model. Clin Toxicol (Phila). 2014 Jun; 52(5):490-7. Brenner M, Benavides S, Mahon SB, Lee J, Yoon D, Mukai D, Viseroi M, Chan A, Jiang J, Narula N, Azer SM, Alexander C, Boss GR. PMID: 24716792; PMCID: PMC4149338.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    54. Oxidation-Induced Trapping of Drugs in Porous Silicon Microparticles. Chem Mater. 2014 Apr 22; 26(8):2758-2764. Fry NL, Boss GR, Sailor MJ. PMID: 25678746; PMCID: PMC4311935.
      View in: PubMed   Mentions: 7  
    55. Kinetics and mechanism of oxidation of super-reduced cobalamin and cobinamide species by thiosulfate, sulfite and dithionite. Dalton Trans. 2013 Nov 21; 42(43):15307-16. Dereven'kov IA, Salnikov DS, Makarov SV, Boss GR, Koifman OI. PMID: 23999614; PMCID: PMC3813607.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    56. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. Biochem J. 2013 Aug 15; 454(1):91-9. Fridman A, Saha A, Chan A, Casteel DE, Pilz RB, Boss GR. PMID: 23734909.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    57. Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase. Cell Signal. 2013 Dec; 25(12):2374-82. Spitler R, Schwappacher R, Wu T, Kong X, Yokomori K, Pilz RB, Boss GR, Berns MW. PMID: 23920342.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    58. Toxicokinetic profiles of α-ketoglutarate cyanohydrin, a cyanide detoxification product, following exposure to potassium cyanide. Toxicol Lett. 2013 Sep 12; 222(1):83-9. Mitchell BL, Bhandari RK, Bebarta VS, Rockwood GA, Boss GR, Logue BA. PMID: 23867915.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    59. Comparison of a new cobinamide-based method to a standard laboratory method for measuring cyanide in human blood. J Anal Toxicol. 2013 Jul-Aug; 37(6):382-5. Swezey R, Shinn W, Green C, Drover DR, Hammer GB, Schulman SR, Zajicek A, Jett DA, Boss GR. PMID: 23653045; PMCID: PMC3708715.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    60. Comparative study of reaction of cobalamin and cobinamide with thiocyanate. J Inorg Biochem. 2013 Aug; 125:32-9. Dereven'kov IA, Salnikov DS, Makarov SV, Surducan M, Silaghi-Dumitrescu R, Boss GR. PMID: 23685470.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    61. A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension. J Biol Chem. 2013 Jun 07; 288(23):16557-16566. Schwappacher R, Kilic A, Kojonazarov B, Lang M, Diep T, Zhuang S, Gawlowski T, Schermuly RT, Pfeifer A, Boss GR, Pilz RB. PMID: 23612967; PMCID: PMC3675591.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    62. ACP Journal Club: allopurinol during acute gout attacks did not differ from delayed allopurinol for pain or recurrence. Ann Intern Med. 2013 Apr 16; 158(8):JC6. Boss GR. PMID: 23588771.
      View in: PubMed   Mentions:    Fields:    
    63. A disposable blood cyanide sensor. Anal Chim Acta. 2013 Mar 20; 768:129-35. Tian Y, Dasgupta PK, Mahon SB, Ma J, Brenner M, Wang JH, Boss GR. PMID: 23473259; PMCID: PMC3596829.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    64. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. PMID: 23345455; PMCID: PMC3633825.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    65. Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism. J Biomed Opt. 2012 Oct; 17(10):105005. Kim JG, Lee J, Mahon SB, Mukai D, Patterson SE, Boss GR, Tromberg BJ, Brenner M. PMID: 23223999; PMCID: PMC3603151.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    66. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J Biol Chem. 2012 Nov 02; 287(45):38367-78. Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB. PMID: 22992742; PMCID: PMC3488105.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    67. Cobinamide chemistries for photometric cyanide determination. A merging zone liquid core waveguide cyanide analyzer using cyanoaquacobinamide. Anal Chim Acta. 2012 Jul 29; 736:78-84. Ma J, Dasgupta PK, Zelder FH, Boss GR. PMID: 22769008; PMCID: PMC3392611.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    68. Protein kinase G and focal adhesion kinase converge on Src/Akt/β-catenin signaling module in osteoblast mechanotransduction. J Biol Chem. 2012 Jun 15; 287(25):21509-19. Rangaswami H, Schwappacher R, Tran T, Chan GC, Zhuang S, Boss GR, Pilz RB. PMID: 22563076; PMCID: PMC3375572.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    69. Pro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II. J Biol Chem. 2012 Jan 06; 287(2):978-88. Marathe N, Rangaswami H, Zhuang S, Boss GR, Pilz RB. PMID: 22117068; PMCID: PMC3256896.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    70. Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(II) complex. Dalton Trans. 2011 Oct 14; 40(38):9831-4. Salnikov DS, Silaghi-Dumitrescu R, Makarov SV, van Eldik R, Boss GR. PMID: 21879074.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    71. The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning. Clin Toxicol (Phila). 2011 Jun; 49(5):366-73. Chan A, Crankshaw DL, Monteil A, Patterson SE, Nagasawa HT, Briggs JE, Kozocas JA, Mahon SB, Brenner M, Pilz RB, Bigby TD, Boss GR. PMID: 21740135; PMCID: PMC3882312.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    72. Rapid point of care analyzer for the measurement of cyanide in blood. Anal Chem. 2011 Jun 01; 83(11):4319-24. Ma J, Ohira S, Mishra SK, Puanngam M, Dasgupta PK, Mahon SB, Brenner M, Blackledge W, Boss GR. PMID: 21553921; PMCID: PMC3105183.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    73. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. PMID: 21177494; PMCID: PMC3093297.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    74. Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity. Toxicol Appl Pharmacol. 2010 Nov 01; 248(3):269-76. Brenner M, Kim JG, Lee J, Mahon SB, Lemor D, Ahdout R, Boss GR, Blackledge W, Jann L, Nagasawa HT, Patterson SE. PMID: 20705081; PMCID: PMC3382974.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    75. Cobinamide is superior to other treatments in a mouse model of cyanide poisoning. Clin Toxicol (Phila). 2010 Aug; 48(7):709-17. Chan A, Balasubramanian M, Blackledge W, Mohammad OM, Alvarez L, Boss GR, Bigby TD. PMID: 20704457; PMCID: PMC3119202.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    76. Cobinamide-based cyanide analysis by multiwavelength spectrometry in a liquid core waveguide. Anal Chem. 2010 Jul 15; 82(14):6244-50. Ma J, Dasgupta PK, Blackledge W, Boss GR. PMID: 20560532; PMCID: PMC2912415.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    77. New facile method to measure cyanide in blood. Anal Chem. 2010 May 15; 82(10):4216-21. Blackledge WC, Blackledge CW, Griesel A, Mahon SB, Brenner M, Pilz RB, Boss GR. PMID: 20420400; PMCID: PMC2889625.
      View in: PubMed   Mentions: 24     Fields:    
    78. Temperature dependence of Henry's law constant for hydrogen cyanide. Generation of trace standard gaseous hydrogen cyanide. Environ Sci Technol. 2010 Apr 15; 44(8):3028-34. Ma J, Dasgupta PK, Blackledge W, Boss GR. PMID: 20302333; PMCID: PMC2855313.
      View in: PubMed   Mentions: 7     Fields:    
    79. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J. 2010 Jun; 24(6):2056-65. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V. PMID: 20097874; PMCID: PMC2874475.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    80. Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicity. Ann Emerg Med. 2010 Apr; 55(4):352-63. Brenner M, Kim JG, Mahon SB, Lee J, Kreuter KA, Blackledge W, Mukai D, Patterson S, Mohammad O, Sharma VS, Boss GR. PMID: 20045579; PMCID: PMC2963429.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    81. Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring. J Biomed Opt. 2010 Jan-Feb; 15(1):017001. Brenner M, Mahon SB, Lee J, Kim J, Mukai D, Goodman S, Kreuter KA, Ahdout R, Mohammad O, Sharma VS, Blackledge W, Boss GR. PMID: 20210475; PMCID: PMC2816993.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    82. Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J Biol Chem. 2009 May 29; 284(22):14796-808. Rangaswami H, Marathe N, Zhuang S, Chen Y, Yeh JC, Frangos JA, Boss GR, Pilz RB. PMID: 19282289; PMCID: PMC2685661.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    83. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem. 2009 Feb 27; 284(9):5807-18. Casteel DE, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB. PMID: 19119139; PMCID: PMC2645831.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    84. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J Biol Chem. 2009 Feb 06; 284(6):3521-8. Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. PMID: 19068483; PMCID: PMC2635033.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    85. Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation. Ann Hematol. 2009 Apr; 88(4):319-24. Raepple D, von Lintig F, Zemojtel T, Duchniewicz M, Jung A, Lübbert M, Boss GR, Scheele JS. PMID: 18784923; PMCID: PMC2755762.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    86. Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J Infect Dis. 2008 Feb 01; 197(3):457-64. Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. PMID: 18199034.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    87. Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis. Evid Based Med. 2007 Dec; 12(6):175. Boss GR. PMID: 18063735.
      View in: PubMed   Mentions:    Fields:    
    88. Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp Biol Med (Maywood). 2007 Dec; 232(11):1432-40. Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, Boss GR. PMID: 18040067.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    89. A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase. J Biol Chem. 2007 Nov 16; 282(46):33367-33380. Zhang T, Zhuang S, Casteel DE, Looney DJ, Boss GR, Pilz RB. PMID: 17878170.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    90. Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol. 2008 Jan 15; 75(2):405-13. Turner SJ, Zhuang S, Zhang T, Boss GR, Pilz RB. PMID: 17920041; PMCID: PMC2228324.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    91. Signaling by small GTPases in the immune system. Immunol Rev. 2007 Aug; 218:92-101. Scheele JS, Marks RE, Boss GR. PMID: 17624946.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    92. The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide. Exp Biol Med (Maywood). 2007 Jun; 232(6):789-98. Broderick KE, Balasubramanian M, Chan A, Potluri P, Feala J, Belke DD, McCulloch A, Sharma VS, Pilz RB, Bigby TD, Boss GR. PMID: 17526771.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    93. Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Mol Endocrinol. 2007 May; 21(5):1148-62. Broderick KE, Zhang T, Rangaswami H, Zeng Y, Zhao X, Boss GR, Pilz RB. PMID: 17341596.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    94. The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis. FASEB J. 2006 Sep; 20(11):1865-73. Broderick KE, Feala J, McCulloch A, Paternostro G, Sharma VS, Pilz RB, Boss GR. PMID: 16940158.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    95. Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. Cancer Res. 2006 Jun 01; 66(11):5656-64. Cohen G, Mustafi R, Chumsangsri A, Little N, Nathanson J, Cerda S, Jagadeeswaran S, Dougherty U, Joseph L, Hart J, Yerian L, Tretiakova M, Yuan W, Obara P, Khare S, Sinicrope FA, Fichera A, Boss GR, Carroll R, Bissonnette M. PMID: 16740703.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    96. Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation. Am J Physiol Renal Physiol. 2006 Nov; 291(5):F1078-82. Satriano J, Wead L, Cardus A, Deng A, Boss GR, Thomson SC, Blantz RC. PMID: 16705150.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    97. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood). 2006 May; 231(5):641-9. Broderick KE, Potluri P, Zhuang S, Scheffler IE, Sharma VS, Pilz RB, Boss GR. PMID: 16636313.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    98. Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4. J Biol Chem. 2006 Jun 23; 281(25):16951-16961. Zeng Y, Zhuang S, Gloddek J, Tseng CC, Boss GR, Pilz RB. PMID: 16632465.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    99. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. J Biol Chem. 2005 Nov 18; 280(46):38211-8. Casteel DE, Boss GR, Pilz RB. PMID: 16166082.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    100. Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3. J Biol Chem. 2005 Sep 23; 280(38):32683-92. Zhao X, Zhuang S, Chen Y, Boss GR, Pilz RB. PMID: 16055922.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    101. Nitric oxide inhibits mammalian methylmalonyl-CoA mutase. J Biol Chem. 2005 Mar 18; 280(11):10073-82. Kambo A, Sharma VS, Casteel DE, Woods VL, Pilz RB, Boss GR. PMID: 15647267.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    102. Nitric oxide scavenging by the cobalamin precursor cobinamide. J Biol Chem. 2005 Mar 11; 280(10):8678-85. Broderick KE, Singh V, Zhuang S, Kambo A, Chen JC, Sharma VS, Pilz RB, Boss GR. PMID: 15632180.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
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