Loading...

Gerry Boss

Title(s)Professor, Medicine
SchoolHealth Sciences
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Sodium Tetrathionate as a Cyanide Antidote
    NIH/NINDS U01NS105057Sep 1, 2017 - May 31, 2020
    Role: Principal Investigator
    Development of antidotes for toxic gases
    NIH U54ES027698Sep 30, 2016 - Aug 31, 2021
    Role: Co-Investigator
    Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide Antidote
    NIH/NINDS U01NS087964Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    A Discovery and Development Pipeline for Cyanide Countermeasures
    NIH U54NS079201Sep 30, 2012 - Aug 31, 2017
    Role: Co-Investigator
    Blood Donor Drives & High School Students to Educate People About Organ Donation
    NIH/NIDDK R01DK098780Sep 30, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
    NIH/NINDS R21NS072105Sep 26, 2011 - Aug 31, 2014
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Aug 13, 2009 - Mar 31, 2014
    Role: Co-Investigator
    Educating High School Students and Their Families about Clinical Research (Phase
    NIH/NCRR R25RR022714Jul 23, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Combined Use of Cobinamide and a 3-Mercaptopyruvate Prodrug for Cyanide Poisoning
    NIH U54NS063718Sep 30, 2008 - May 31, 2012
    Role: Co-Investigator
    Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying Agent
    NIH/NINDS U01NS058030Sep 27, 2006 - May 31, 2011
    Role: Principal Investigator
    Pre-Clinical Studies of the NO Scavenger Cobinamide
    NIH/NIAID R21AI064368Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Analysis of Ras and Rho Activation in Prostate Cancer
    NIH/NCI R01CA090932Feb 1, 2002 - Jan 31, 2007
    Role: Principal Investigator
    AUTOMATED MEASUREMENT OF RAS &RHO ACTIVATION IN CANCER
    NIH/NCI R33CA089828Feb 1, 2001 - Jan 31, 2005
    Role: Principal Investigator
    Physician-Scientist Research Training Program
    NIH/NIDDK T32DK069263Sep 1, 1999 - Jun 30, 2016
    Role: Principal Investigator
    GENERALIST PHYSICIAN-SCIENTIST TRAINING PROGRAM
    NIH/NCI T32CA081211May 5, 1999 - Jun 30, 2005
    Role: Principal Investigator
    MEASUREMENT OF RAS ACTIVATION IN LUNG CANCER
    NIH/NCI R21CA081115Apr 1, 1999 - Mar 31, 2001
    Role: Principal Investigator
    PUBLIC HEALTH ORGANIZATION AT MORSE &HELIX HS-PHASE II
    NIH/NCRR R25RR012389Jul 10, 1998 - Jun 30, 2005
    Role: Principal Investigator
    DEVELOPMENT OF AN AUTOMATED RAS MEASUREMENT DEVICE
    NIH/NCI R21CA076968Sep 30, 1997 - Sep 29, 2000
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Co-Investigator
    RAS-RELATED PROTEIN IN DIFFERENTIATING MEL CELLS
    NIH/NIGMS R01GM049360May 1, 1993 - Apr 30, 1997
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB. Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat Commun. 2019 08 06; 10(1):3533. PMID: 31387997.
      View in: PubMed
    2. Ng PC, Hendry-Hofer TB, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS. Efficacy of Oral Administration of Sodium Thiosulfate and Glycine in a Large, Swine Model of Oral Cyanide Toxicity. Ann Emerg Med. 2019 Sep; 74(3):423-429. PMID: 31080026.
      View in: PubMed
    3. Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Haouzi P, Bebarta VS. Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development. J Med Toxicol. 2019 10; 15(4):287-294. PMID: 31062177.
      View in: PubMed
    4. Petrikovics I, Kiss L, Chou CE, Ebrahimpour A, Kovács K, Kiss M, Logue B, Chan A, Manage ABW, Budai M, Boss GR, Rockwood GA. Antidotal efficacies of the cyanide antidote candidate dimethyl trisulfide alone and in combination with cobinamide derivatives. Toxicol Mech Methods. 2019 Jul; 29(6):438-444. PMID: 30822191.
      View in: PubMed
    5. Hendry-Hofer TB, Witeof AE, Ng PC, Mahon SB, Brenner M, Boss GR, Bebarta VS. Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity. Clin Toxicol (Phila). 2020 Jan; 58(1):29-35. PMID: 31008657.
      View in: PubMed
    6. Hendry-Hofer TB, Ng PC, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS. A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges. J Med Toxicol. 2019 Apr; 15(2):128-133. PMID: 30539383.
      View in: PubMed
    7. Ng PC, Hendry-Hofer TB, Garrett N, Brenner M, Mahon SB, Maddry JK, Haouzi P, Boss GR, Gibbons TF, Araña AA, Bebarta VS. Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine. Clin Toxicol (Phila). 2019 03; 57(3):189-196. PMID: 30430872.
      View in: PubMed
    8. Morningstar J, Lee J, Hendry-Hofer T, Witeof A, Lyle LT, Knipp G, MacRae CA, Boss GR, Peterson RT, Davisson VJ, Gerszten RE, Bebarta VS, Mahon S, Brenner M, Nath AK. Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning. FASEB Bioadv. 2019 Feb; 1(2):81-92. PMID: 31355359.
      View in: PubMed
    9. Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Bebarta VS. Characterization of a Swine (Sus scrofa) Model of Oral Potassium Cyanide Intoxication. Comp Med. 2018 10 01; 68(5):375-379. PMID: 30208987.
      View in: PubMed
    10. Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018; 13(6):e0193889. PMID: 29879736.
      View in: PubMed
    11. Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Ann N Y Acad Sci. 2017 11; 1408(1):61-78. PMID: 29239480.
      View in: PubMed
    12. Greenawald LA, Boss GR, Snyder JL, Reeder A, Bell S. Development of an Inexpensive RGB Color Sensor for the Detection of Hydrogen Cyanide Gas. ACS Sens. 2017 10 27; 2(10):1458-1466. PMID: 28967741.
      View in: PubMed
    13. Bebarta VS, Garrett N, Brenner M, Mahon SB, Maddry JK, Boudreau S, Castaneda M, Boss GR. Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model. Acad Emerg Med. 2017 09; 24(9):1088-1098. PMID: 28472554.
      View in: PubMed
    14. Brenner M, Azer SM, Oh KJ, Han CH, Lee J, Mahon SB, Du X, Mukai D, Burney T, Saidian M, Chan A, Straker DI, Bebarta VS, Boss GR. Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion. J Clin Toxicol. 2017 Jun; 7(3). PMID: 28868209.
      View in: PubMed
    15. Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol. 2017 May 18; 24(5):565-575.e4. PMID: 28416275.
      View in: PubMed
    16. Tsai CS, Mao RW, Tsai SC, Shahverdi K, Zhu Y, Lin SK, Hsu YH, Boss G, Brenner M, Mahon S, Smaldone GC. Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications. Micromachines (Basel). 2017; 8(2). PMID: 29250438.
      View in: PubMed
    17. Bebarta VS, Brittain M, Chan A, Garrett N, Yoon D, Burney T, Mukai D, Babin M, Pilz RB, Mahon SB, Brenner M, Boss GR. Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. Ann Emerg Med. 2017 Jun; 69(6):718-725.e4. PMID: 28041825.
      View in: PubMed
    18. Sahu D, Gupta S, Hau AM, Nakashima K, Leivo MZ, Searles SC, Elson P, Bomalaski JS, Casteel DE, Boss GR, Hansel DE. Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2a Activity and Is Targetable by Pegylated Arginine Deiminase. Am J Pathol. 2017 01; 187(1):200-213. PMID: 27979310.
      View in: PubMed
    19. Lee J, Mahon SB, Mukai D, Burney T, Katebian BS, Chan A, Bebarta VS, Yoon D, Boss GR, Brenner M. The Vitamin B12 Analog Cobinamide Is an Effective Antidote for Oral Cyanide Poisoning. J Med Toxicol. 2016 12; 12(4):370-379. PMID: 27631586.
      View in: PubMed
    20. Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel DE, Pilz RB. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. J Bone Miner Res. 2017 01; 32(1):46-59. PMID: 27391172.
      View in: PubMed
    21. MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT. A countermeasure development pipeline. Ann N Y Acad Sci. 2016 08; 1378(1):58-67. PMID: 27737495.
      View in: PubMed
    22. Greenawald LA, Boss GR, Reeder A, Bell S. Development of a Hydrogen Sulfide End-of-Service-Life Indicator for Respirator Cartridges Using Cobinamide. Sens Actuators B Chem. 2016 Jul; 230:658-666. PMID: 27022206.
      View in: PubMed
    23. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. PMID: 26815411.
      View in: PubMed
    24. Kambale KJ, Ali ER, Sadiki NH, Kayembe KP, Mvumbi LG, Yandju DL, Boivin MJ, Boss GR, Stadler DD, Lambert WE, Lasarev MR, Okitundu LA, Mumba Ngoyi D, Banea JP, Tshala-Katumbay DD. Lower sulfurtransferase detoxification rates of cyanide in konzo-A tropical spastic paralysis linked to cassava cyanogenic poisoning. Neurotoxicology. 2017 03; 59:256-262. PMID: 27246648.
      View in: PubMed
    25. Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016 Feb 15; 6:20831. PMID: 26877209.
      View in: PubMed
    26. Greenawald LA, Snyder JL, Fry NL, Sailor MJ, Boss GR, Finklea HO, Bell S. Development of a cobinamide-based end-of-service-life indicator for detection of hydrogen cyanide gas. Sens Actuators B Chem. 2015 Dec 31; 221:379-385. PMID: 26213448.
      View in: PubMed
    27. Stutelberg MW, Dzisam JK, Monteil AR, Petrikovics I, Boss GR, Patterson SE, Rockwood GA, Logue BA. Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 01; 1008:181-188. PMID: 26655110.
      View in: PubMed
    28. Wassenaar JW, Boss GR, Christman KL. Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials. 2015 Sep; 64:108-14. PMID: 26125502.
      View in: PubMed
    29. Kadjo AF, Dasgupta PK, Boss GR. Comment on "Rapid visual detection of blood cyanide" by C. Männel-Croisé and F. Zelder, Analytical Methods, 2012, 4, 2632. Anal Methods. 2015; 7(13):5707-5711. PMID: 26640525.
      View in: PubMed
    30. Spitler R, Ho H, Norpetlian F, Kong X, Jiang J, Yokomori K, Andersen B, Boss GR, Berns MW. Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing. J Biomed Opt. 2015 May; 20(5):051022. PMID: 25562608.
      View in: PubMed
    31. Chan A, Jiang J, Fridman A, Guo LT, Shelton GD, Liu MT, Green C, Haushalter KJ, Patel HH, Lee J, Yoon D, Burney T, Mukai D, Mahon SB, Brenner M, Pilz RB, Boss GR. Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection. J Med Chem. 2015 Feb 26; 58(4):1750-9. PMID: 25650735.
      View in: PubMed
    32. Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR. In reply. Ann Emerg Med. 2015 Feb; 65(2):235. PMID: 25601262.
      View in: PubMed
    33. Joshua J, Schwaerzer GK, Kalyanaraman H, Cory E, Sah RL, Li M, Vaida F, Boss GR, Pilz RB. Soluble guanylate cyclase as a novel treatment target for osteoporosis. Endocrinology. 2014 Dec; 155(12):4720-30. PMID: 25188528.
      View in: PubMed
    34. Salnikov DS, Makarov SV, van Eldik R, Kucherenko PN, Boss GR. Kinetics and mechanism of the reaction of hydrogen sulfide with diaquacobinamide in aqueous solution. Eur J Inorg Chem. 2014 Sep; 2014(25):4123-4133. PMID: 25580081.
      View in: PubMed
    35. Saha A, Connelly S, Jiang J, Zhuang S, Amador DT, Phan T, Pilz RB, Boss GR. Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis. Mol Cell. 2014 Jul 17; 55(2):264-76. PMID: 24981175.
      View in: PubMed
    36. Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel DE, Frangos JA, Dillmann W, Boss GR, Pilz RB. Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor. Sci Signal. 2014 May 20; 7(326):ra48. PMID: 24847117.
      View in: PubMed
    37. Lee J, Kim JG, Mahon SB, Mukai D, Yoon D, Boss GR, Patterson SE, Rockwood G, Isom G, Brenner M. Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy. J Biomed Opt. 2014 May; 19(5):055001. PMID: 24788369.
      View in: PubMed
    38. Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR. Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model. Ann Emerg Med. 2014 Dec; 64(6):612-9. PMID: 24746273.
      View in: PubMed
    39. Brenner M, Benavides S, Mahon SB, Lee J, Yoon D, Mukai D, Viseroi M, Chan A, Jiang J, Narula N, Azer SM, Alexander C, Boss GR. The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model. Clin Toxicol (Phila). 2014 Jun; 52(5):490-7. PMID: 24716792.
      View in: PubMed
    40. Fry NL, Boss GR, Sailor MJ. Oxidation-Induced Trapping of Drugs in Porous Silicon Microparticles. Chem Mater. 2014 Apr 22; 26(8):2758-2764. PMID: 25678746.
      View in: PubMed
    41. Dereven'kov IA, Salnikov DS, Makarov SV, Boss GR, Koifman OI. Kinetics and mechanism of oxidation of super-reduced cobalamin and cobinamide species by thiosulfate, sulfite and dithionite. Dalton Trans. 2013 Nov 21; 42(43):15307-16. PMID: 23999614.
      View in: PubMed
    42. Fridman A, Saha A, Chan A, Casteel DE, Pilz RB, Boss GR. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. Biochem J. 2013 Aug 15; 454(1):91-9. PMID: 23734909.
      View in: PubMed
    43. Spitler R, Schwappacher R, Wu T, Kong X, Yokomori K, Pilz RB, Boss GR, Berns MW. Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase. Cell Signal. 2013 Dec; 25(12):2374-82. PMID: 23920342.
      View in: PubMed
    44. Mitchell BL, Bhandari RK, Bebarta VS, Rockwood GA, Boss GR, Logue BA. Toxicokinetic profiles of a-ketoglutarate cyanohydrin, a cyanide detoxification product, following exposure to potassium cyanide. Toxicol Lett. 2013 Sep 12; 222(1):83-9. PMID: 23867915.
      View in: PubMed
    45. Swezey R, Shinn W, Green C, Drover DR, Hammer GB, Schulman SR, Zajicek A, Jett DA, Boss GR. Comparison of a new cobinamide-based method to a standard laboratory method for measuring cyanide in human blood. J Anal Toxicol. 2013 Jul-Aug; 37(6):382-5. PMID: 23653045.
      View in: PubMed
    46. Dereven'kov IA, Salnikov DS, Makarov SV, Surducan M, Silaghi-Dumitrescu R, Boss GR. Comparative study of reaction of cobalamin and cobinamide with thiocyanate. J Inorg Biochem. 2013 Aug; 125:32-9. PMID: 23685470.
      View in: PubMed
    47. Schwappacher R, Kilic A, Kojonazarov B, Lang M, Diep T, Zhuang S, Gawlowski T, Schermuly RT, Pfeifer A, Boss GR, Pilz RB. A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension. J Biol Chem. 2013 Jun 07; 288(23):16557-66. PMID: 23612967.
      View in: PubMed
    48. Boss GR. ACP Journal Club: allopurinol during acute gout attacks did not differ from delayed allopurinol for pain or recurrence. Ann Intern Med. 2013 Apr 16; 158(8):JC6. PMID: 23588771.
      View in: PubMed
    49. Tian Y, Dasgupta PK, Mahon SB, Ma J, Brenner M, Wang JH, Boss GR. A disposable blood cyanide sensor. Anal Chim Acta. 2013 Mar 20; 768:129-35. PMID: 23473259.
      View in: PubMed
    50. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. PMID: 23345455.
      View in: PubMed
    51. Kim JG, Lee J, Mahon SB, Mukai D, Patterson SE, Boss GR, Tromberg BJ, Brenner M. Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism. J Biomed Opt. 2012 Oct; 17(10):105005. PMID: 23223999.
      View in: PubMed
    52. Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J Biol Chem. 2012 Nov 02; 287(45):38367-78. PMID: 22992742.
      View in: PubMed
    53. Ma J, Dasgupta PK, Zelder FH, Boss GR. Cobinamide chemistries for photometric cyanide determination. A merging zone liquid core waveguide cyanide analyzer using cyanoaquacobinamide. Anal Chim Acta. 2012 Jul 29; 736:78-84. PMID: 22769008.
      View in: PubMed
    54. Rangaswami H, Schwappacher R, Tran T, Chan GC, Zhuang S, Boss GR, Pilz RB. Protein kinase G and focal adhesion kinase converge on Src/Akt/ß-catenin signaling module in osteoblast mechanotransduction. J Biol Chem. 2012 Jun 15; 287(25):21509-19. PMID: 22563076.
      View in: PubMed
    55. Marathe N, Rangaswami H, Zhuang S, Boss GR, Pilz RB. Pro-survival effects of 17ß-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II. J Biol Chem. 2012 Jan 06; 287(2):978-88. PMID: 22117068.
      View in: PubMed
    56. Salnikov DS, Silaghi-Dumitrescu R, Makarov SV, van Eldik R, Boss GR. Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(II) complex. Dalton Trans. 2011 Oct 14; 40(38):9831-4. PMID: 21879074.
      View in: PubMed
    57. Chan A, Crankshaw DL, Monteil A, Patterson SE, Nagasawa HT, Briggs JE, Kozocas JA, Mahon SB, Brenner M, Pilz RB, Bigby TD, Boss GR. The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning. Clin Toxicol (Phila). 2011 Jun; 49(5):366-73. PMID: 21740135.
      View in: PubMed
    58. Ma J, Ohira S, Mishra SK, Puanngam M, Dasgupta PK, Mahon SB, Brenner M, Blackledge W, Boss GR. Rapid point of care analyzer for the measurement of cyanide in blood. Anal Chem. 2011 Jun 01; 83(11):4319-24. PMID: 21553921.
      View in: PubMed
    59. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. PMID: 21177494.
      View in: PubMed
    60. Brenner M, Kim JG, Lee J, Mahon SB, Lemor D, Ahdout R, Boss GR, Blackledge W, Jann L, Nagasawa HT, Patterson SE. Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity. Toxicol Appl Pharmacol. 2010 Nov 01; 248(3):269-76. PMID: 20705081.
      View in: PubMed
    61. Chan A, Balasubramanian M, Blackledge W, Mohammad OM, Alvarez L, Boss GR, Bigby TD. Cobinamide is superior to other treatments in a mouse model of cyanide poisoning. Clin Toxicol (Phila). 2010 Aug; 48(7):709-17. PMID: 20704457.
      View in: PubMed
    62. Ma J, Dasgupta PK, Blackledge W, Boss GR. Cobinamide-based cyanide analysis by multiwavelength spectrometry in a liquid core waveguide. Anal Chem. 2010 Jul 15; 82(14):6244-50. PMID: 20560532.
      View in: PubMed
    63. Blackledge WC, Blackledge CW, Griesel A, Mahon SB, Brenner M, Pilz RB, Boss GR. New facile method to measure cyanide in blood. Anal Chem. 2010 May 15; 82(10):4216-21. PMID: 20420400.
      View in: PubMed
    64. Ma J, Dasgupta PK, Blackledge W, Boss GR. Temperature dependence of Henry's law constant for hydrogen cyanide. Generation of trace standard gaseous hydrogen cyanide. Environ Sci Technol. 2010 Apr 15; 44(8):3028-34. PMID: 20302333.
      View in: PubMed
    65. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J. 2010 Jun; 24(6):2056-65. PMID: 20097874.
      View in: PubMed
    66. Brenner M, Kim JG, Mahon SB, Lee J, Kreuter KA, Blackledge W, Mukai D, Patterson S, Mohammad O, Sharma VS, Boss GR. Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicity. Ann Emerg Med. 2010 Apr; 55(4):352-63. PMID: 20045579.
      View in: PubMed
    67. Brenner M, Mahon SB, Lee J, Kim J, Mukai D, Goodman S, Kreuter KA, Ahdout R, Mohammad O, Sharma VS, Blackledge W, Boss GR. Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring. J Biomed Opt. 2010 Jan-Feb; 15(1):017001. PMID: 20210475.
      View in: PubMed
    68. Rangaswami H, Marathe N, Zhuang S, Chen Y, Yeh JC, Frangos JA, Boss GR, Pilz RB. Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J Biol Chem. 2009 May 29; 284(22):14796-808. PMID: 19282289.
      View in: PubMed
    69. Casteel DE, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem. 2009 Feb 27; 284(9):5807-18. PMID: 19119139.
      View in: PubMed
    70. Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J Biol Chem. 2009 Feb 06; 284(6):3521-8. PMID: 19068483.
      View in: PubMed
    71. Raepple D, von Lintig F, Zemojtel T, Duchniewicz M, Jung A, Lübbert M, Boss GR, Scheele JS. Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation. Ann Hematol. 2009 Apr; 88(4):319-24. PMID: 18784923.
      View in: PubMed
    72. Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J Infect Dis. 2008 Feb 01; 197(3):457-64. PMID: 18199034.
      View in: PubMed
    73. Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, Boss GR. Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp Biol Med (Maywood). 2007 Dec; 232(11):1432-40. PMID: 18040067.
      View in: PubMed
    74. Boss GR. Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis. Evid Based Med. 2007 Dec; 12(6):175. PMID: 18063735.
      View in: PubMed
    75. Zhang T, Zhuang S, Casteel DE, Looney DJ, Boss GR, Pilz RB. A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase. J Biol Chem. 2007 Nov 16; 282(46):33367-80. PMID: 17878170.
      View in: PubMed
    76. Turner SJ, Zhuang S, Zhang T, Boss GR, Pilz RB. Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol. 2008 Jan 15; 75(2):405-13. PMID: 17920041.
      View in: PubMed
    77. Scheele JS, Marks RE, Boss GR. Signaling by small GTPases in the immune system. Immunol Rev. 2007 Aug; 218:92-101. PMID: 17624946.
      View in: PubMed
    78. Broderick KE, Balasubramanian M, Chan A, Potluri P, Feala J, Belke DD, McCulloch A, Sharma VS, Pilz RB, Bigby TD, Boss GR. The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide. Exp Biol Med (Maywood). 2007 Jun; 232(6):789-98. PMID: 17526771.
      View in: PubMed
    79. Broderick KE, Zhang T, Rangaswami H, Zeng Y, Zhao X, Boss GR, Pilz RB. Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Mol Endocrinol. 2007 May; 21(5):1148-62. PMID: 17341596.
      View in: PubMed
    80. Broderick KE, Feala J, McCulloch A, Paternostro G, Sharma VS, Pilz RB, Boss GR. The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis. FASEB J. 2006 Sep; 20(11):1865-73. PMID: 16940158.
      View in: PubMed
    81. Cohen G, Mustafi R, Chumsangsri A, Little N, Nathanson J, Cerda S, Jagadeeswaran S, Dougherty U, Joseph L, Hart J, Yerian L, Tretiakova M, Yuan W, Obara P, Khare S, Sinicrope FA, Fichera A, Boss GR, Carroll R, Bissonnette M. Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. Cancer Res. 2006 Jun 01; 66(11):5656-64. PMID: 16740703.
      View in: PubMed
    82. Satriano J, Wead L, Cardus A, Deng A, Boss GR, Thomson SC, Blantz RC. Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation. Am J Physiol Renal Physiol. 2006 Nov; 291(5):F1078-82. PMID: 16705150.
      View in: PubMed
    83. Broderick KE, Potluri P, Zhuang S, Scheffler IE, Sharma VS, Pilz RB, Boss GR. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood). 2006 May; 231(5):641-9. PMID: 16636313.
      View in: PubMed
    84. Zeng Y, Zhuang S, Gloddek J, Tseng CC, Boss GR, Pilz RB. Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4. J Biol Chem. 2006 Jun 23; 281(25):16951-61. PMID: 16632465.
      View in: PubMed
    85. Casteel DE, Boss GR, Pilz RB. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. J Biol Chem. 2005 Nov 18; 280(46):38211-8. PMID: 16166082.
      View in: PubMed
    86. Zhao X, Zhuang S, Chen Y, Boss GR, Pilz RB. Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3. J Biol Chem. 2005 Sep 23; 280(38):32683-92. PMID: 16055922.
      View in: PubMed
    87. Kambo A, Sharma VS, Casteel DE, Woods VL, Pilz RB, Boss GR. Nitric oxide inhibits mammalian methylmalonyl-CoA mutase. J Biol Chem. 2005 Mar 18; 280(11):10073-82. PMID: 15647267.
      View in: PubMed
    88. Broderick KE, Singh V, Zhuang S, Kambo A, Chen JC, Sharma VS, Pilz RB, Boss GR. Nitric oxide scavenging by the cobalamin precursor cobinamide. J Biol Chem. 2005 Mar 11; 280(10):8678-85. PMID: 15632180.
      View in: PubMed
    89. Zhuang S, Nguyen GT, Chen Y, Gudi T, Eigenthaler M, Jarchau T, Walter U, Boss GR, Pilz RB. Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation. J Biol Chem. 2004 Mar 12; 279(11):10397-407. PMID: 14679200.
      View in: PubMed
    90. Sharma VS, Pilz RB, Boss GR, Magde D. Reactions of nitric oxide with vitamin B12 and its precursor, cobinamide. Biochemistry. 2003 Jul 29; 42(29):8900-8. PMID: 12873151.
      View in: PubMed
    91. Khare S, Cerda S, Wali RK, von Lintig FC, Tretiakova M, Joseph L, Stoiber D, Cohen G, Nimmagadda K, Hart J, Sitrin MD, Boss GR, Bissonnette M. Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. Cancer Res. 2003 Jul 01; 63(13):3517-23. PMID: 12839936.
      View in: PubMed
    92. Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB. Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol Cell Biol. 2003 Jun; 23(12):4066-82. PMID: 12773552.
      View in: PubMed
    93. Gudi S, Huvar I, White CR, McKnight NL, Dusserre N, Boss GR, Frangos JA. Rapid activation of Ras by fluid flow is mediated by Galpha(q) and Gbetagamma subunits of heterotrimeric G proteins in human endothelial cells. Arterioscler Thromb Vasc Biol. 2003 Jun 01; 23(6):994-1000. PMID: 12714438.
      View in: PubMed
    94. Lau N, Uhlmann EJ, Von Lintig FC, Nagy A, Boss GR, Gutmann DH, Guha A. Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression. Int J Oncol. 2003 Jan; 22(1):195-200. PMID: 12469204.
      View in: PubMed
    95. Chen JC, Zhuang S, Nguyen TH, Boss GR, Pilz RB. Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity. J Biol Chem. 2003 Jan 31; 278(5):2807-18. PMID: 12429740.
      View in: PubMed
    96. Hansen LA, Boss GR. Use of live animals in the curricula of U.S. medical schools: survey results from 2001. Acad Med. 2002 Nov; 77(11):1147-9. PMID: 12431930.
      View in: PubMed
    97. Im E, von Lintig FC, Chen J, Zhuang S, Qui W, Chowdhury S, Worley PF, Boss GR, Pilz RB. Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene. 2002 Sep 12; 21(41):6356-65. PMID: 12214276.
      View in: PubMed
    98. Woods SA, Marmor E, Feldkamp M, Lau N, Apicelli AJ, Boss G, Gutmann DH, Guha A. Aberrant G protein signaling in nervous system tumors. J Neurosurg. 2002 Sep; 97(3):627-42. PMID: 12296648.
      View in: PubMed
    99. Gudi T, Chen JC, Casteel DE, Seasholtz TM, Boss GR, Pilz RB. cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions. J Biol Chem. 2002 Oct 04; 277(40):37382-93. PMID: 12119292.
      View in: PubMed
    100. Chen JC, von Lintig FC, Jones SB, Huvar I, Boss GR. High-efficiency solid-phase capture using glass beads bonded to microcentrifuge tubes: immunoprecipitation of proteins from cell extracts and assessment of ras activation. Anal Biochem. 2002 Mar 15; 302(2):298-304. PMID: 11878811.
      View in: PubMed
    101. Danishpajooh IO, Gudi T, Chen Y, Kharitonov VG, Sharma VS, Boss GR. Nitric oxide inhibits methionine synthase activity in vivo and disrupts carbon flow through the folate pathway. J Biol Chem. 2001 Jul 20; 276(29):27296-303. PMID: 11371572.
      View in: PubMed
    102. Liu ML, Shibata MA, Von Lintig FC, Wang W, Cassenaer S, Boss GR, Green JE. Haploid loss of Ki-ras delays mammary tumor progression in C3 (1)/SV40 Tag transgenic mice. Oncogene. 2001 Apr 12; 20(16):2044-9. PMID: 11360188.
      View in: PubMed
    103. Dupuy AJ, Morgan K, von Lintig FC, Shen H, Acar H, Hasz DE, Jenkins NA, Copeland NG, Boss GR, Largaespada DA. Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia. J Biol Chem. 2001 Apr 13; 276(15):11804-11. PMID: 11278453.
      View in: PubMed
    104. Gudi T, Casteel DE, Vinson C, Boss GR, Pilz RB. NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation. Oncogene. 2000 Dec 14; 19(54):6324-33. PMID: 11175347.
      View in: PubMed
    105. Qiu W, Zhuang S, von Lintig FC, Boss GR, Pilz RB. Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins. J Biol Chem. 2000 Oct 13; 275(41):31921-9. PMID: 10931830.
      View in: PubMed
    106. von Lintig FC, Pilz RB, Boss GR. Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells. Oncogene. 2000 Aug 17; 19(35):4029-34. PMID: 10962559.
      View in: PubMed
    107. Bissonnette M, Khare S, von Lintig FC, Wali RK, Nguyen L, Zhang Y, Hart J, Skarosi S, Varki N, Boss GR, Brasitus TA. Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1. Cancer Res. 2000 Aug 15; 60(16):4602-9. PMID: 10969813.
      View in: PubMed
    108. von Lintig FC, Dreilinger AD, Varki NM, Wallace AM, Casteel DE, Boss GR. Ras activation in human breast cancer. Breast Cancer Res Treat. 2000 Jul; 62(1):51-62. PMID: 10989985.
      View in: PubMed
    109. von Lintig FC, Huvar I, Law P, Diccianni MB, Yu AL, Boss GR. Ras activation in normal white blood cells and childhood acute lymphoblastic leukemia. Clin Cancer Res. 2000 May; 6(5):1804-10. PMID: 10815901.
      View in: PubMed
    110. Tian W, Boss GR, Cohen DM. Ras signaling in the inner medullary cell response to urea and NaCl. Am J Physiol Cell Physiol. 2000 Feb; 278(2):C372-80. PMID: 10666033.
      View in: PubMed
    111. Egawa K, Sharma PM, Nakashima N, Huang Y, Huver E, Boss GR, Olefsky JM. Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance. J Biol Chem. 1999 May 14; 274(20):14306-14. PMID: 10318852.
      View in: PubMed
    112. Idriss SD, Gudi T, Casteel DE, Kharitonov VG, Pilz RB, Boss GR. Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase. J Biol Chem. 1999 Apr 02; 274(14):9489-93. PMID: 10092632.
      View in: PubMed
    113. Khare S, Bissonnette M, Wali R, Skarosi S, Boss GR, von Lintig FC, Scaglione-Sewell B, Sitrin MD, Brasitus TA. 1,25-dihydroxyvitamin D3 but not TPA activates PLD in Caco-2 cells via pp60(c-src) and RhoA. Am J Physiol. 1999 Apr; 276(4 Pt 1):G1005-15. PMID: 10198345.
      View in: PubMed
    114. Suhasini M, Li H, Lohmann SM, Boss GR, Pilz RB. Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway. Mol Cell Biol. 1998 Dec; 18(12):6983-94. PMID: 9819386.
      View in: PubMed
    115. Liu ML, Von Lintig FC, Liyanage M, Shibata MA, Jorcyk CL, Ried T, Boss GR, Green JE. Amplification of Ki-ras and elevation of MAP kinase activity during mammary tumor progression in C3(1)/SV40 Tag transgenic mice. Oncogene. 1998 Nov 05; 17(18):2403-11. PMID: 9811472.
      View in: PubMed
    116. Scheele JS, Pilz RB, von Lintig FC, Boss GR. Deficient post-translational processing of Rap 1A in variant HL-60 cells. Oncogene. 1998 Oct 29; 17(17):2211-23. PMID: 9811452.
      View in: PubMed
    117. Scheele JS, Pilz RB, Clark G, Gupta N, Loo D, Martis P, Boss GR. Decreased phosphorylation of a low molecular weight protein by cGMP-dependent protein kinase in variant HL-60 cells resistant to nitric oxide- and cGMP-induced differentiation. Mol Cell Biochem. 1998 Aug; 185(1-2):111-21. PMID: 9746217.
      View in: PubMed
    118. Sharma PM, Egawa K, Huang Y, Martin JL, Huvar I, Boss GR, Olefsky JM. Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action. J Biol Chem. 1998 Jul 17; 273(29):18528-37. PMID: 9660823.
      View in: PubMed
    119. Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P. Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver. Biochem Pharmacol. 1998 Jul 01; 56(1):15-23. PMID: 9698084.
      View in: PubMed
    120. Ruiz-Lozano P, Smith SM, Perkins G, Kubalak SW, Boss GR, Sucov HM, Evans RM, Chien KR. Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos. Development. 1998 Feb; 125(3):533-44. PMID: 9425147.
      View in: PubMed
    121. Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene. 1997 Dec 04; 15(23):2755-65. PMID: 9419966.
      View in: PubMed
    122. Talwar N, Pilz RB, Yu Z, Burlingame A, Boss GR. A low molecular weight substance purified from human placenta inhibits cAMP-dependent protein kinase and activates protein kinase C. Mol Cell Biochem. 1997 May; 170(1-2):75-83. PMID: 9144320.
      View in: PubMed
    123. Pilz RB, Huvar I, Scheele JS, Van den Berghe G, Boss GR. A decrease in the intracellular guanosine 5'-triphosphate concentration is necessary for granulocytic differentiation of HL-60 cells, but growth cessation and differentiation are not associated with a change in the activation state of Ras, the transforming principle of HL-60 cells. Cell Growth Differ. 1997 Jan; 8(1):53-9. PMID: 8993834.
      View in: PubMed
    124. Helmer GA, McKirnan MD, Shabetai R, Boss GR, Ross J, Hammond HK. Regional deficits of myocardial blood flow and function in left ventricular pacing-induced heart failure. Circulation. 1996 Nov 01; 94(9):2260-7. PMID: 8901681.
      View in: PubMed
    125. Prigent SA, Nagane M, Lin H, Huvar I, Boss GR, Feramisco JR, Cavenee WK, Huang HS. Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway. J Biol Chem. 1996 Oct 11; 271(41):25639-45. PMID: 8810340.
      View in: PubMed
    126. Boss GR. Is clinical subspecialty training necessary to become a physician-scientist? J Investig Med. 1996 Apr; 44(4):136-8. PMID: 8689408.
      View in: PubMed
    127. Gudi T, Huvar I, Meinecke M, Lohmann SM, Boss GR, Pilz RB. Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter. J Biol Chem. 1996 Mar 01; 271(9):4597-600. PMID: 8617718.
      View in: PubMed
    128. Guha A, Lau N, Huvar I, Gutmann D, Provias J, Pawson T, Boss G. Ras-GTP levels are elevated in human NF1 peripheral nerve tumors. Oncogene. 1996 Feb 01; 12(3):507-13. PMID: 8637706.
      View in: PubMed
    129. Suhasini M, Boss GR, Pascual FE, Pilz RB. Nitric oxide-releasing agents and cGMP analogues inhibit murine erythroleukemia cell differentiation and suppress erythroid-specific gene expression: correlation with decreased DNA binding of NF-E2 and altered c-myb mRNA expression. Cell Growth Differ. 1995 Dec; 6(12):1559-66. PMID: 9019161.
      View in: PubMed
    130. Pilz RB, Suhasini M, Idriss S, Meinkoth JL, Boss GR. Nitric oxide and cGMP analogs activate transcription from AP-1-responsive promoters in mammalian cells. FASEB J. 1995 Apr; 9(7):552-8. PMID: 7737465.
      View in: PubMed
    131. Scheele JS, Rhee JM, Boss GR. Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):1097-100. PMID: 7862641.
      View in: PubMed
    132. Pilz RB, Berjis M, Idriss SD, Scheele JS, Suhasini M, Gao L, Scheffler IE, Boss GR. Isolation and characterization of HL-60 cells resistant to nitroprusside-induced differentiation. J Biol Chem. 1994 Dec 23; 269(51):32155-61. PMID: 7798212.
      View in: PubMed
    133. Scheele JS, Pilz RB, Quilliam LA, Boss GR. Identification of a ras-related protein in murine erythroleukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induced differentiation. J Biol Chem. 1994 Jul 15; 269(28):18599-606. PMID: 8034608.
      View in: PubMed
    134. Sorscher SM, Steeg P, Feramisco JR, Buckmaster C, Boss GR, Meinkoth J. Microinjection of an nm23 specific antibody inhibits cell division in rat embryo fibroblasts. Biochem Biophys Res Commun. 1993 Aug 31; 195(1):336-45. PMID: 8395830.
      View in: PubMed
    135. Pilz RB, Eigenthaler M, Boss GR. Chemically induced murine erythroleukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes. J Biol Chem. 1992 Aug 15; 267(23):16161-7. PMID: 1644803.
      View in: PubMed
    136. Durrer A, Wernly-Chung GN, Boss G, Testa B. Enzymic hydrolysis of nicotinate esters: comparison between plasma and liver catalysis. Xenobiotica. 1992 Mar; 22(3):273-82. PMID: 1496819.
      View in: PubMed
    137. Idriss SD, Pilz RB, Sharma VS, Boss GR. Studies on cytosolic guanylate cyclase from human placenta. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):312-20. PMID: 1347448.
      View in: PubMed
    138. Sharma VS, Bandyopadhyay D, Berjis M, Rifkind J, Boss GR. Double-mixing kinetic studies of the reactions of monoliganded species of hemoglobin: alpha 2(CO)1 beta 2 and alpha 2 beta 2(CO)1. J Biol Chem. 1991 Dec 25; 266(36):24492-7. PMID: 1761549.
      View in: PubMed
    139. Jacobson DL, McCutchan JA, Spechko PL, Abramson I, Smith RS, Bartok A, Boss GR, Durand D, Bozzette SA, Spector SA. The evolution of lymphadenopathy and hypergammaglobulinemia are evidence for early and sustained polyclonal B lymphocyte activation during human immunodeficiency virus infection. J Infect Dis. 1991 Feb; 163(2):240-6. PMID: 1671053.
      View in: PubMed
    140. White FC, Boss G. Inotropic interventions during myocardial "stunning" in the pig. Am J Cardiovasc Pathol. 1990; 3(3):225-36. PMID: 2095829.
      View in: PubMed
    141. Moore EC, Hurlbert RB, Boss GR, Massia SP. Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989 Nov 15; 38(22):4045-51. PMID: 2480792.
      View in: PubMed
    142. Boss GR. cGMP-induced differentiation of the promyelocytic cell line HL-60. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7174-8. PMID: 2550930.
      View in: PubMed
    143. Pilz RB, Van den Berghe G, Boss GR. Adenosine dialdehyde and nitrous oxide induce HL-60 differentiation. Blood. 1987 Oct; 70(4):1161-4. PMID: 3651602.
      View in: PubMed
    144. Boss GR. Purine deoxynucleosides and adenosine dialdehyde decrease 5-amino-4-imidazolecarboxamide (Z-base)-dependent purine nucleotide synthesis in cultured T and B lymphoblasts. Biochem J. 1987 Mar 01; 242(2):425-31. PMID: 3109390.
      View in: PubMed
    145. Pilz RB, Van den Berghe G, Boss GR. Induction of HL-60 differentiation by starvation for a single essential amino acid but not by protein synthesis inhibitors. J Clin Invest. 1987 Mar; 79(3):1006-9. PMID: 3469216.
      View in: PubMed
    146. Pilz RB, Boss GR. The synthesis of phosphoribosylpyrophosphate from glucose decreases during amino acid starvation of human lymphoblasts. Adv Exp Med Biol. 1986; 195 Pt B:611-4. PMID: 2429513.
      View in: PubMed
    147. Boss GR. Cobalamin inactivation decreases purine and methionine synthesis in cultured human lymphoblasts. Adv Exp Med Biol. 1986; 195 Pt B:639-41. PMID: 3094331.
      View in: PubMed
    148. Boss GR. Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts. J Clin Invest. 1985 Jul; 76(1):213-8. PMID: 2862163.
      View in: PubMed
    149. Boss GR, Pilz RB. Phosphoribosylpyrophosphate synthesis from glucose decreases during amino acid starvation of human lymphoblasts. J Biol Chem. 1985 May 25; 260(10):6054-9. PMID: 2581946.
      View in: PubMed
    150. Boss GR, Pilz RB. Decreased methionine synthesis in purine nucleoside-treated T and B lymphoblasts and reversal by homocysteine. J Clin Invest. 1984 Oct; 74(4):1262-8. PMID: 6332827.
      View in: PubMed
    151. Boss GR. Decreased phosphoribosylpyrophosphate as the basis for decreased purine synthesis during amino acid starvation of human lymphoblasts. J Biol Chem. 1984 Mar 10; 259(5):2936-41. PMID: 6199353.
      View in: PubMed
    152. Pilz RB, Willis RC, Boss GR. The influence of ribose 5-phosphate availability on purine synthesis of cultured human lymphoblasts and mitogen-stimulated lymphocytes. J Biol Chem. 1984 Mar 10; 259(5):2927-35. PMID: 6699001.
      View in: PubMed
    153. Boss GR, Idriss SD, Willis RC, Seegmiller JE. Synthesis of (14C)-ribose-5-phosphate and (14C)-phosphoribosylpyrophosphate and their use in new enzyme assays. Adv Exp Med Biol. 1984; 165 Pt B:11-3. PMID: 6202119.
      View in: PubMed
    154. Boss GR. Purine synthesis during amino acid starvation of lymphoblasts with HPRT deficiency or PP-ribose-P synthetase overactivity decreases less than in normal cells. Adv Exp Med Biol. 1984; 165 Pt B:15-9. PMID: 6326498.
      View in: PubMed
    155. Boss GR, Idriss SD, Willis RC, Seegmiller JE. Assay of glutamine phosphoribosylpyrophosphate amidotransferase using [1-14C]phosphoribosylpyrophosphate. Anal Biochem. 1983 Apr 01; 130(1):283-6. PMID: 6191593.
      View in: PubMed
    156. Boss GR, Erbe RW. Decreased purine synthesis during amino acid starvation of human lymphoblasts. J Biol Chem. 1982 Apr 25; 257(8):4242-7. PMID: 6279630.
      View in: PubMed
    157. Boss GR, Erbe RW. Decreased rates of methionine synthesis by methylene tetrahydrofolate reductase-deficient fibroblasts and lymphoblasts. J Clin Invest. 1981 Jun; 67(6):1659-64. PMID: 6113252.
      View in: PubMed
    158. Boss GR, Thompson LF, O'Connor RD, Ziering RW, Seegmiller JE. Ecto-5'-nucleotidase deficiency: association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity. Clin Immunol Immunopathol. 1981 Apr; 19(1):1-7. PMID: 6260402.
      View in: PubMed
    159. Boss GR, Thompson LF, Spiegelberg HL, Pichler WJ, Seegmiller JE. Age-dependency of lymphocyte ecto-5'-nucleotidase activity. J Immunol. 1980 Aug; 125(2):679-82. PMID: 6248594.
      View in: PubMed
    160. Thompson LF, Boss GR, Spiegelberg HL, Bianchino A, Seegmiller JE. Ecto-5'-nucleotidase activity in lymphoblastoid cell lines derived from heterozygotes for congenital X-linked agammaglobulinemia. J Immunol. 1980 Jul; 125(1):190-3. PMID: 6247393.
      View in: PubMed
    161. Howell SB, Herbst K, Boss GR, Frei E. Thymidine requirements for the rescue of patients treated with high-dose methotrexate. Cancer Res. 1980 Jun; 40(6):1824-9. PMID: 7371013.
      View in: PubMed
    162. Thompson LF, Boss GR, Spiegelberg HL, Jansen IV, O'Connor RD, Waldmann TA, Hamburger RN, Seegmiller JE. Ecto-5'-nucleotidase activity in T and B lymphocytes from normal subjects and patients with congenital X-linked agammaglobulinemia. J Immunol. 1979 Dec; 123(6):2475-8. PMID: 315423.
      View in: PubMed
    163. Thompson LF, Boss GR, Bianchino A, Seegmiller JE. Activity of ecto-5'-nucleotidase in lymphoblastoid cell lines derived from carriers of congenital X-linked agammaglobulinemia. Adv Exp Med Biol. 1979; 122B:327-32. PMID: 232636.
      View in: PubMed
    164. Boss GR, Thompson LF, Spiegelberg HL, Waldmann TA, O'Connor RD, Hamburger RN, Seegmiller JE. Lymphocyte ecto-5'-nucleotidase activity as a marker of B-cell maturation. Trans Assoc Am Physicians. 1979; 92:309-15. PMID: 232944.
      View in: PubMed