Gerry Boss

Title(s)Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0652
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Sodium Tetrathionate as a Cyanide Antidote
    NIH/NINDS U01NS105057Sep 1, 2017 - May 31, 2020
    Role: Principal Investigator
    Development of antidotes for toxic gases
    NIH U54ES027698Sep 30, 2016 - Aug 31, 2021
    Role: Co-Investigator
    Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide Antidote
    NIH/NINDS U01NS087964Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    A Discovery and Development Pipeline for Cyanide Countermeasures
    NIH U54NS079201Sep 30, 2012 - Aug 31, 2017
    Role: Co-Investigator
    Blood Donor Drives & High School Students to Educate People About Organ Donation
    NIH/NIDDK R01DK098780Sep 30, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
    NIH/NINDS R21NS072105Sep 26, 2011 - Aug 31, 2014
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Aug 13, 2009 - Mar 31, 2014
    Role: Co-Investigator
    Educating High School Students and Their Families about Clinical Research (Phase
    NIH/NCRR R25RR022714Jul 23, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Combined Use of Cobinamide and a 3-Mercaptopyruvate Prodrug for Cyanide Poisoning
    NIH U54NS063718Sep 30, 2008 - May 31, 2012
    Role: Co-Investigator
    Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying Agent
    NIH/NINDS U01NS058030Sep 27, 2006 - May 31, 2011
    Role: Principal Investigator
    Pre-Clinical Studies of the NO Scavenger Cobinamide
    NIH/NIAID R21AI064368Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Analysis of Ras and Rho Activation in Prostate Cancer
    NIH/NCI R01CA090932Feb 1, 2002 - Jan 31, 2007
    Role: Principal Investigator
    NIH/NCI R33CA089828Feb 1, 2001 - Jan 31, 2005
    Role: Principal Investigator
    Physician-Scientist Research Training Program
    NIH/NIDDK T32DK069263Sep 1, 1999 - Jun 30, 2016
    Role: Principal Investigator
    NIH/NCI T32CA081211May 5, 1999 - Jun 30, 2005
    Role: Principal Investigator
    NIH/NCI R21CA081115Apr 1, 1999 - Mar 31, 2001
    Role: Principal Investigator
    NIH/NCRR R25RR012389Jul 10, 1998 - Jun 30, 2005
    Role: Principal Investigator
    NIH/NCI R21CA076968Sep 30, 1997 - Sep 29, 2000
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Co-Investigator
    NIH/NIGMS R01GM049360May 1, 1993 - Apr 30, 1997
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Intramuscular aminotetrazole cobinamide as a treatment for inhaled hydrogen sulfide poisoning in a large swine model. Ann N Y Acad Sci. 2020 Mar 31. Hendry-Hofer TB, Ng PC, McGrath AM, Mukai D, Brenner M, Mahon S, Maddry JK, Boss GR, Bebarta VS. PMID: 32233102.
      View in: PubMed   Mentions:    Fields:    
    2. Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat Commun. 2019 08 06; 10(1):3533. Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB. PMID: 31387997.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Efficacy of Oral Administration of Sodium Thiosulfate and Glycine in a Large, Swine Model of Oral Cyanide Toxicity. Ann Emerg Med. 2019 09; 74(3):423-429. Ng PC, Hendry-Hofer TB, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS. PMID: 31080026.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development. J Med Toxicol. 2019 10; 15(4):287-294. Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Haouzi P, Bebarta VS. PMID: 31062177.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    5. Antidotal efficacies of the cyanide antidote candidate dimethyl trisulfide alone and in combination with cobinamide derivatives. Toxicol Mech Methods. 2019 Jul; 29(6):438-444. Petrikovics I, Kiss L, Chou CE, Ebrahimpour A, Kovács K, Kiss M, Logue B, Chan A, Manage ABW, Budai M, Boss GR, Rockwood GA. PMID: 30822191.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity. Clin Toxicol (Phila). 2020 Jan; 58(1):29-35. Hendry-Hofer TB, Witeof AE, Ng PC, Mahon SB, Brenner M, Boss GR, Bebarta VS. PMID: 31008657.
      View in: PubMed   Mentions:    Fields:    
    7. A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges. J Med Toxicol. 2019 Apr; 15(2):128-133. Hendry-Hofer TB, Ng PC, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS. PMID: 30539383.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine. Clin Toxicol (Phila). 2019 03; 57(3):189-196. Ng PC, Hendry-Hofer TB, Garrett N, Brenner M, Mahon SB, Maddry JK, Haouzi P, Boss GR, Gibbons TF, Araña AA, Bebarta VS. PMID: 30430872.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning. FASEB Bioadv. 2019 Feb; 1(2):81-92. Morningstar J, Lee J, Hendry-Hofer T, Witeof A, Lyle LT, Knipp G, MacRae CA, Boss GR, Peterson RT, Davisson VJ, Gerszten RE, Bebarta VS, Mahon S, Brenner M, Nath AK. PMID: 31355359.
      View in: PubMed   Mentions:
    10. Characterization of a Swine (Sus scrofa) Model of Oral Potassium Cyanide Intoxication. Comp Med. 2018 10 01; 68(5):375-379. Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Bebarta VS. PMID: 30208987.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    11. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018; 13(6):e0193889. Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. PMID: 29879736.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Ann N Y Acad Sci. 2017 11; 1408(1):61-78. Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK. PMID: 29239480.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Development of an Inexpensive RGB Color Sensor for the Detection of Hydrogen Cyanide Gas. ACS Sens. 2017 10 27; 2(10):1458-1466. Greenawald LA, Boss GR, Snyder JL, Reeder A, Bell S. PMID: 28967741.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model. Acad Emerg Med. 2017 09; 24(9):1088-1098. Bebarta VS, Garrett N, Brenner M, Mahon SB, Maddry JK, Boudreau S, Castaneda M, Boss GR. PMID: 28472554.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    15. Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion. J Clin Toxicol. 2017 Jun; 7(3). Brenner M, Azer SM, Oh KJ, Han CH, Lee J, Mahon SB, Du X, Mukai D, Burney T, Saidian M, Chan A, Straker DI, Bebarta VS, Boss GR. PMID: 28868209.
      View in: PubMed   Mentions:
    16. Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol. 2017 May 18; 24(5):565-575.e4. Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. PMID: 28416275.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications. Micromachines (Basel). 2017; 8(2). Tsai CS, Mao RW, Tsai SC, Shahverdi K, Zhu Y, Lin SK, Hsu YH, Boss G, Brenner M, Mahon S, Smaldone GC. PMID: 29250438.
      View in: PubMed   Mentions:
    18. Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. Ann Emerg Med. 2017 Jun; 69(6):718-725.e4. Bebarta VS, Brittain M, Chan A, Garrett N, Yoon D, Burney T, Mukai D, Babin M, Pilz RB, Mahon SB, Brenner M, Boss GR. PMID: 28041825.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    19. Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2a Activity and Is Targetable by Pegylated Arginine Deiminase. Am J Pathol. 2017 01; 187(1):200-213. Sahu D, Gupta S, Hau AM, Nakashima K, Leivo MZ, Searles SC, Elson P, Bomalaski JS, Casteel DE, Boss GR, Hansel DE. PMID: 27979310.
      View in: PubMed   Mentions: 3     Fields:    
    20. The Vitamin B12 Analog Cobinamide Is an Effective Antidote for Oral Cyanide Poisoning. J Med Toxicol. 2016 12; 12(4):370-379. Lee J, Mahon SB, Mukai D, Burney T, Katebian BS, Chan A, Bebarta VS, Yoon D, Boss GR, Brenner M. PMID: 27631586.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. J Bone Miner Res. 2017 01; 32(1):46-59. Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel DE, Pilz RB. PMID: 27391172.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. A countermeasure development pipeline. Ann N Y Acad Sci. 2016 08; 1378(1):58-67. MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT. PMID: 27737495.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    23. Development of a Hydrogen Sulfide End-of-Service-Life Indicator for Respirator Cartridges Using Cobinamide. Sens Actuators B Chem. 2016 Jul; 230:658-666. Greenawald LA, Boss GR, Reeder A, Bell S. PMID: 27022206.
      View in: PubMed   Mentions:
    24. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. PMID: 26815411.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    25. Lower sulfurtransferase detoxification rates of cyanide in konzo-A tropical spastic paralysis linked to cassava cyanogenic poisoning. Neurotoxicology. 2017 03; 59:256-262. Kambale KJ, Ali ER, Sadiki NH, Kayembe KP, Mvumbi LG, Yandju DL, Boivin MJ, Boss GR, Stadler DD, Lambert WE, Lasarev MR, Okitundu LA, Mumba Ngoyi D, Banea JP, Tshala-Katumbay DD. PMID: 27246648.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016 Feb 15; 6:20831. Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. PMID: 26877209.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    27. Development of a cobinamide-based end-of-service-life indicator for detection of hydrogen cyanide gas. Sens Actuators B Chem. 2015 Dec 31; 221:379-385. Greenawald LA, Snyder JL, Fry NL, Sailor MJ, Boss GR, Finklea HO, Bell S. PMID: 26213448.
      View in: PubMed   Mentions:
    28. Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 01; 1008:181-188. Stutelberg MW, Dzisam JK, Monteil AR, Petrikovics I, Boss GR, Patterson SE, Rockwood GA, Logue BA. PMID: 26655110.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    29. Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials. 2015 Sep; 64:108-14. Wassenaar JW, Boss GR, Christman KL. PMID: 26125502.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    30. Comment on "Rapid visual detection of blood cyanide" by C. Männel-Croisé and F. Zelder, Analytical Methods, 2012, 4, 2632. Anal Methods. 2015; 7(13):5707-5711. Kadjo AF, Dasgupta PK, Boss GR. PMID: 26640525.
      View in: PubMed   Mentions:
    31. Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing. J Biomed Opt. 2015 May; 20(5):051022. Spitler R, Ho H, Norpetlian F, Kong X, Jiang J, Yokomori K, Andersen B, Boss GR, Berns MW. PMID: 25562608.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    32. Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection. J Med Chem. 2015 Feb 26; 58(4):1750-9. Chan A, Jiang J, Fridman A, Guo LT, Shelton GD, Liu MT, Green C, Haushalter KJ, Patel HH, Lee J, Yoon D, Burney T, Mukai D, Mahon SB, Brenner M, Pilz RB, Boss GR. PMID: 25650735.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. In reply. Ann Emerg Med. 2015 Feb; 65(2):235. Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR. PMID: 25601262.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    34. Soluble guanylate cyclase as a novel treatment target for osteoporosis. Endocrinology. 2014 Dec; 155(12):4720-30. Joshua J, Schwaerzer GK, Kalyanaraman H, Cory E, Sah RL, Li M, Vaida F, Boss GR, Pilz RB. PMID: 25188528.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. Kinetics and mechanism of the reaction of hydrogen sulfide with diaquacobinamide in aqueous solution. Eur J Inorg Chem. 2014 Sep; 2014(25):4123-4133. Salnikov DS, Makarov SV, van Eldik R, Kucherenko PN, Boss GR. PMID: 25580081.
      View in: PubMed   Mentions:
    36. Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis. Mol Cell. 2014 Jul 17; 55(2):264-76. Saha A, Connelly S, Jiang J, Zhuang S, Amador DT, Phan T, Pilz RB, Boss GR. PMID: 24981175.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    37. Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor. Sci Signal. 2014 May 20; 7(326):ra48. Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel DE, Frangos JA, Dillmann W, Boss GR, Pilz RB. PMID: 24847117.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    38. Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy. J Biomed Opt. 2014 May; 19(5):055001. Lee J, Kim JG, Mahon SB, Mukai D, Yoon D, Boss GR, Patterson SE, Rockwood G, Isom G, Brenner M. PMID: 24788369.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    39. Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model. Ann Emerg Med. 2014 Dec; 64(6):612-9. Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR. PMID: 24746273.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    40. The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model. Clin Toxicol (Phila). 2014 Jun; 52(5):490-7. Brenner M, Benavides S, Mahon SB, Lee J, Yoon D, Mukai D, Viseroi M, Chan A, Jiang J, Narula N, Azer SM, Alexander C, Boss GR. PMID: 24716792.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    41. Oxidation-Induced Trapping of Drugs in Porous Silicon Microparticles. Chem Mater. 2014 Apr 22; 26(8):2758-2764. Fry NL, Boss GR, Sailor MJ. PMID: 25678746.
      View in: PubMed   Mentions:
    42. Kinetics and mechanism of oxidation of super-reduced cobalamin and cobinamide species by thiosulfate, sulfite and dithionite. Dalton Trans. 2013 Nov 21; 42(43):15307-16. Dereven'kov IA, Salnikov DS, Makarov SV, Boss GR, Koifman OI. PMID: 23999614.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    43. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. Biochem J. 2013 Aug 15; 454(1):91-9. Fridman A, Saha A, Chan A, Casteel DE, Pilz RB, Boss GR. PMID: 23734909.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    44. Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase. Cell Signal. 2013 Dec; 25(12):2374-82. Spitler R, Schwappacher R, Wu T, Kong X, Yokomori K, Pilz RB, Boss GR, Berns MW. PMID: 23920342.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    45. Toxicokinetic profiles of a-ketoglutarate cyanohydrin, a cyanide detoxification product, following exposure to potassium cyanide. Toxicol Lett. 2013 Sep 12; 222(1):83-9. Mitchell BL, Bhandari RK, Bebarta VS, Rockwood GA, Boss GR, Logue BA. PMID: 23867915.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    46. Comparison of a new cobinamide-based method to a standard laboratory method for measuring cyanide in human blood. J Anal Toxicol. 2013 Jul-Aug; 37(6):382-5. Swezey R, Shinn W, Green C, Drover DR, Hammer GB, Schulman SR, Zajicek A, Jett DA, Boss GR. PMID: 23653045.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    47. Comparative study of reaction of cobalamin and cobinamide with thiocyanate. J Inorg Biochem. 2013 Aug; 125:32-9. Dereven'kov IA, Salnikov DS, Makarov SV, Surducan M, Silaghi-Dumitrescu R, Boss GR. PMID: 23685470.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    48. A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension. J Biol Chem. 2013 Jun 07; 288(23):16557-66. Schwappacher R, Kilic A, Kojonazarov B, Lang M, Diep T, Zhuang S, Gawlowski T, Schermuly RT, Pfeifer A, Boss GR, Pilz RB. PMID: 23612967.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    49. ACP Journal Club: allopurinol during acute gout attacks did not differ from delayed allopurinol for pain or recurrence. Ann Intern Med. 2013 Apr 16; 158(8):JC6. Boss GR. PMID: 23588771.
      View in: PubMed   Mentions:    Fields:    
    50. A disposable blood cyanide sensor. Anal Chim Acta. 2013 Mar 20; 768:129-35. Tian Y, Dasgupta PK, Mahon SB, Ma J, Brenner M, Wang JH, Boss GR. PMID: 23473259.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    51. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. PMID: 23345455.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    52. Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism. J Biomed Opt. 2012 Oct; 17(10):105005. Kim JG, Lee J, Mahon SB, Mukai D, Patterson SE, Boss GR, Tromberg BJ, Brenner M. PMID: 23223999.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    53. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J Biol Chem. 2012 Nov 02; 287(45):38367-78. Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB. PMID: 22992742.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    54. Cobinamide chemistries for photometric cyanide determination. A merging zone liquid core waveguide cyanide analyzer using cyanoaquacobinamide. Anal Chim Acta. 2012 Jul 29; 736:78-84. Ma J, Dasgupta PK, Zelder FH, Boss GR. PMID: 22769008.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    55. Protein kinase G and focal adhesion kinase converge on Src/Akt/ß-catenin signaling module in osteoblast mechanotransduction. J Biol Chem. 2012 Jun 15; 287(25):21509-19. Rangaswami H, Schwappacher R, Tran T, Chan GC, Zhuang S, Boss GR, Pilz RB. PMID: 22563076.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    56. Pro-survival effects of 17ß-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II. J Biol Chem. 2012 Jan 06; 287(2):978-88. Marathe N, Rangaswami H, Zhuang S, Boss GR, Pilz RB. PMID: 22117068.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    57. Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(II) complex. Dalton Trans. 2011 Oct 14; 40(38):9831-4. Salnikov DS, Silaghi-Dumitrescu R, Makarov SV, van Eldik R, Boss GR. PMID: 21879074.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    58. The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning. Clin Toxicol (Phila). 2011 Jun; 49(5):366-73. Chan A, Crankshaw DL, Monteil A, Patterson SE, Nagasawa HT, Briggs JE, Kozocas JA, Mahon SB, Brenner M, Pilz RB, Bigby TD, Boss GR. PMID: 21740135.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    59. Rapid point of care analyzer for the measurement of cyanide in blood. Anal Chem. 2011 Jun 01; 83(11):4319-24. Ma J, Ohira S, Mishra SK, Puanngam M, Dasgupta PK, Mahon SB, Brenner M, Blackledge W, Boss GR. PMID: 21553921.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    60. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. PMID: 21177494.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    61. Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity. Toxicol Appl Pharmacol. 2010 Nov 01; 248(3):269-76. Brenner M, Kim JG, Lee J, Mahon SB, Lemor D, Ahdout R, Boss GR, Blackledge W, Jann L, Nagasawa HT, Patterson SE. PMID: 20705081.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    62. Cobinamide is superior to other treatments in a mouse model of cyanide poisoning. Clin Toxicol (Phila). 2010 Aug; 48(7):709-17. Chan A, Balasubramanian M, Blackledge W, Mohammad OM, Alvarez L, Boss GR, Bigby TD. PMID: 20704457.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    63. Cobinamide-based cyanide analysis by multiwavelength spectrometry in a liquid core waveguide. Anal Chem. 2010 Jul 15; 82(14):6244-50. Ma J, Dasgupta PK, Blackledge W, Boss GR. PMID: 20560532.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    64. New facile method to measure cyanide in blood. Anal Chem. 2010 May 15; 82(10):4216-21. Blackledge WC, Blackledge CW, Griesel A, Mahon SB, Brenner M, Pilz RB, Boss GR. PMID: 20420400.
      View in: PubMed   Mentions: 21     Fields:    
    65. Temperature dependence of Henry's law constant for hydrogen cyanide. Generation of trace standard gaseous hydrogen cyanide. Environ Sci Technol. 2010 Apr 15; 44(8):3028-34. Ma J, Dasgupta PK, Blackledge W, Boss GR. PMID: 20302333.
      View in: PubMed   Mentions: 7     Fields:    
    66. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J. 2010 Jun; 24(6):2056-65. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V. PMID: 20097874.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    67. Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicity. Ann Emerg Med. 2010 Apr; 55(4):352-63. Brenner M, Kim JG, Mahon SB, Lee J, Kreuter KA, Blackledge W, Mukai D, Patterson S, Mohammad O, Sharma VS, Boss GR. PMID: 20045579.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    68. Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring. J Biomed Opt. 2010 Jan-Feb; 15(1):017001. Brenner M, Mahon SB, Lee J, Kim J, Mukai D, Goodman S, Kreuter KA, Ahdout R, Mohammad O, Sharma VS, Blackledge W, Boss GR. PMID: 20210475.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    69. Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J Biol Chem. 2009 May 29; 284(22):14796-808. Rangaswami H, Marathe N, Zhuang S, Chen Y, Yeh JC, Frangos JA, Boss GR, Pilz RB. PMID: 19282289.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    70. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem. 2009 Feb 27; 284(9):5807-18. Casteel DE, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB. PMID: 19119139.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    71. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J Biol Chem. 2009 Feb 06; 284(6):3521-8. Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. PMID: 19068483.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    72. Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation. Ann Hematol. 2009 Apr; 88(4):319-24. Raepple D, von Lintig F, Zemojtel T, Duchniewicz M, Jung A, Lübbert M, Boss GR, Scheele JS. PMID: 18784923.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    73. Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J Infect Dis. 2008 Feb 01; 197(3):457-64. Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. PMID: 18199034.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    74. Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp Biol Med (Maywood). 2007 Dec; 232(11):1432-40. Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, Boss GR. PMID: 18040067.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    75. Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis. Evid Based Med. 2007 Dec; 12(6):175. Boss GR. PMID: 18063735.
      View in: PubMed   Mentions:    Fields:    
    76. A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase. J Biol Chem. 2007 Nov 16; 282(46):33367-80. Zhang T, Zhuang S, Casteel DE, Looney DJ, Boss GR, Pilz RB. PMID: 17878170.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    77. Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol. 2008 Jan 15; 75(2):405-13. Turner SJ, Zhuang S, Zhang T, Boss GR, Pilz RB. PMID: 17920041.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    78. Signaling by small GTPases in the immune system. Immunol Rev. 2007 Aug; 218:92-101. Scheele JS, Marks RE, Boss GR. PMID: 17624946.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    79. The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide. Exp Biol Med (Maywood). 2007 Jun; 232(6):789-98. Broderick KE, Balasubramanian M, Chan A, Potluri P, Feala J, Belke DD, McCulloch A, Sharma VS, Pilz RB, Bigby TD, Boss GR. PMID: 17526771.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    80. Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Mol Endocrinol. 2007 May; 21(5):1148-62. Broderick KE, Zhang T, Rangaswami H, Zeng Y, Zhao X, Boss GR, Pilz RB. PMID: 17341596.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    81. The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis. FASEB J. 2006 Sep; 20(11):1865-73. Broderick KE, Feala J, McCulloch A, Paternostro G, Sharma VS, Pilz RB, Boss GR. PMID: 16940158.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    82. Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. Cancer Res. 2006 Jun 01; 66(11):5656-64. Cohen G, Mustafi R, Chumsangsri A, Little N, Nathanson J, Cerda S, Jagadeeswaran S, Dougherty U, Joseph L, Hart J, Yerian L, Tretiakova M, Yuan W, Obara P, Khare S, Sinicrope FA, Fichera A, Boss GR, Carroll R, Bissonnette M. PMID: 16740703.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    83. Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation. Am J Physiol Renal Physiol. 2006 Nov; 291(5):F1078-82. Satriano J, Wead L, Cardus A, Deng A, Boss GR, Thomson SC, Blantz RC. PMID: 16705150.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    84. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood). 2006 May; 231(5):641-9. Broderick KE, Potluri P, Zhuang S, Scheffler IE, Sharma VS, Pilz RB, Boss GR. PMID: 16636313.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    85. Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4. J Biol Chem. 2006 Jun 23; 281(25):16951-61. Zeng Y, Zhuang S, Gloddek J, Tseng CC, Boss GR, Pilz RB. PMID: 16632465.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    86. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. J Biol Chem. 2005 Nov 18; 280(46):38211-8. Casteel DE, Boss GR, Pilz RB. PMID: 16166082.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    87. Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3. J Biol Chem. 2005 Sep 23; 280(38):32683-92. Zhao X, Zhuang S, Chen Y, Boss GR, Pilz RB. PMID: 16055922.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    88. Nitric oxide inhibits mammalian methylmalonyl-CoA mutase. J Biol Chem. 2005 Mar 18; 280(11):10073-82. Kambo A, Sharma VS, Casteel DE, Woods VL, Pilz RB, Boss GR. PMID: 15647267.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    89. Nitric oxide scavenging by the cobalamin precursor cobinamide. J Biol Chem. 2005 Mar 11; 280(10):8678-85. Broderick KE, Singh V, Zhuang S, Kambo A, Chen JC, Sharma VS, Pilz RB, Boss GR. PMID: 15632180.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    90. Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation. J Biol Chem. 2004 Mar 12; 279(11):10397-407. Zhuang S, Nguyen GT, Chen Y, Gudi T, Eigenthaler M, Jarchau T, Walter U, Boss GR, Pilz RB. PMID: 14679200.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    91. Reactions of nitric oxide with vitamin B12 and its precursor, cobinamide. Biochemistry. 2003 Jul 29; 42(29):8900-8. Sharma VS, Pilz RB, Boss GR, Magde D. PMID: 12873151.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    92. Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. Cancer Res. 2003 Jul 01; 63(13):3517-23. Khare S, Cerda S, Wali RK, von Lintig FC, Tretiakova M, Joseph L, Stoiber D, Cohen G, Nimmagadda K, Hart J, Sitrin MD, Boss GR, Bissonnette M. PMID: 12839936.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    93. Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol Cell Biol. 2003 Jun; 23(12):4066-82. Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB. PMID: 12773552.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    94. Rapid activation of Ras by fluid flow is mediated by Galpha(q) and Gbetagamma subunits of heterotrimeric G proteins in human endothelial cells. Arterioscler Thromb Vasc Biol. 2003 Jun 01; 23(6):994-1000. Gudi S, Huvar I, White CR, McKnight NL, Dusserre N, Boss GR, Frangos JA. PMID: 12714438.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    95. Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression. Int J Oncol. 2003 Jan; 22(1):195-200. Lau N, Uhlmann EJ, Von Lintig FC, Nagy A, Boss GR, Gutmann DH, Guha A. PMID: 12469204.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    96. Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity. J Biol Chem. 2003 Jan 31; 278(5):2807-18. Chen JC, Zhuang S, Nguyen TH, Boss GR, Pilz RB. PMID: 12429740.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    97. Use of live animals in the curricula of U.S. medical schools: survey results from 2001. Acad Med. 2002 Nov; 77(11):1147-9. Hansen LA, Boss GR. PMID: 12431930.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    98. Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene. 2002 Sep 12; 21(41):6356-65. Im E, von Lintig FC, Chen J, Zhuang S, Qui W, Chowdhury S, Worley PF, Boss GR, Pilz RB. PMID: 12214276.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    99. Aberrant G protein signaling in nervous system tumors. J Neurosurg. 2002 Sep; 97(3):627-42. Woods SA, Marmor E, Feldkamp M, Lau N, Apicelli AJ, Boss G, Gutmann DH, Guha A. PMID: 12296648.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    100. cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions. J Biol Chem. 2002 Oct 04; 277(40):37382-93. Gudi T, Chen JC, Casteel DE, Seasholtz TM, Boss GR, Pilz RB. PMID: 12119292.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    101. High-efficiency solid-phase capture using glass beads bonded to microcentrifuge tubes: immunoprecipitation of proteins from cell extracts and assessment of ras activation. Anal Biochem. 2002 Mar 15; 302(2):298-304. Chen JC, von Lintig FC, Jones SB, Huvar I, Boss GR. PMID: 11878811.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    102. Nitric oxide inhibits methionine synthase activity in vivo and disrupts carbon flow through the folate pathway. J Biol Chem. 2001 Jul 20; 276(29):27296-303. Danishpajooh IO, Gudi T, Chen Y, Kharitonov VG, Sharma VS, Boss GR. PMID: 11371572.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    103. Haploid loss of Ki-ras delays mammary tumor progression in C3 (1)/SV40 Tag transgenic mice. Oncogene. 2001 Apr 12; 20(16):2044-9. Liu ML, Shibata MA, Von Lintig FC, Wang W, Cassenaer S, Boss GR, Green JE. PMID: 11360188.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    104. Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia. J Biol Chem. 2001 Apr 13; 276(15):11804-11. Dupuy AJ, Morgan K, von Lintig FC, Shen H, Acar H, Hasz DE, Jenkins NA, Copeland NG, Boss GR, Largaespada DA. PMID: 11278453.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    105. NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation. Oncogene. 2000 Dec 14; 19(54):6324-33. Gudi T, Casteel DE, Vinson C, Boss GR, Pilz RB. PMID: 11175347.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    106. Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins. J Biol Chem. 2000 Oct 13; 275(41):31921-9. Qiu W, Zhuang S, von Lintig FC, Boss GR, Pilz RB. PMID: 10931830.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    107. Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells. Oncogene. 2000 Aug 17; 19(35):4029-34. von Lintig FC, Pilz RB, Boss GR. PMID: 10962559.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    108. Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1. Cancer Res. 2000 Aug 15; 60(16):4602-9. Bissonnette M, Khare S, von Lintig FC, Wali RK, Nguyen L, Zhang Y, Hart J, Skarosi S, Varki N, Boss GR, Brasitus TA. PMID: 10969813.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    109. Ras activation in human breast cancer. Breast Cancer Res Treat. 2000 Jul; 62(1):51-62. von Lintig FC, Dreilinger AD, Varki NM, Wallace AM, Casteel DE, Boss GR. PMID: 10989985.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    110. Ras activation in normal white blood cells and childhood acute lymphoblastic leukemia. Clin Cancer Res. 2000 May; 6(5):1804-10. von Lintig FC, Huvar I, Law P, Diccianni MB, Yu AL, Boss GR. PMID: 10815901.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    111. Ras signaling in the inner medullary cell response to urea and NaCl. Am J Physiol Cell Physiol. 2000 Feb; 278(2):C372-80. Tian W, Boss GR, Cohen DM. PMID: 10666033.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    112. Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance. J Biol Chem. 1999 May 14; 274(20):14306-14. Egawa K, Sharma PM, Nakashima N, Huang Y, Huver E, Boss GR, Olefsky JM. PMID: 10318852.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    113. Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase. J Biol Chem. 1999 Apr 02; 274(14):9489-93. Idriss SD, Gudi T, Casteel DE, Kharitonov VG, Pilz RB, Boss GR. PMID: 10092632.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    114. 1,25-dihydroxyvitamin D3 but not TPA activates PLD in Caco-2 cells via pp60(c-src) and RhoA. Am J Physiol. 1999 Apr; 276(4 Pt 1):G1005-15. Khare S, Bissonnette M, Wali R, Skarosi S, Boss GR, von Lintig FC, Scaglione-Sewell B, Sitrin MD, Brasitus TA. PMID: 10198345.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    115. Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway. Mol Cell Biol. 1998 Dec; 18(12):6983-94. Suhasini M, Li H, Lohmann SM, Boss GR, Pilz RB. PMID: 9819386.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    116. Amplification of Ki-ras and elevation of MAP kinase activity during mammary tumor progression in C3(1)/SV40 Tag transgenic mice. Oncogene. 1998 Nov 05; 17(18):2403-11. Liu ML, Von Lintig FC, Liyanage M, Shibata MA, Jorcyk CL, Ried T, Boss GR, Green JE. PMID: 9811472.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    117. Deficient post-translational processing of Rap 1A in variant HL-60 cells. Oncogene. 1998 Oct 29; 17(17):2211-23. Scheele JS, Pilz RB, von Lintig FC, Boss GR. PMID: 9811452.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    118. Decreased phosphorylation of a low molecular weight protein by cGMP-dependent protein kinase in variant HL-60 cells resistant to nitric oxide- and cGMP-induced differentiation. Mol Cell Biochem. 1998 Aug; 185(1-2):111-21. Scheele JS, Pilz RB, Clark G, Gupta N, Loo D, Martis P, Boss GR. PMID: 9746217.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    119. Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action. J Biol Chem. 1998 Jul 17; 273(29):18528-37. Sharma PM, Egawa K, Huang Y, Martin JL, Huvar I, Boss GR, Olefsky JM. PMID: 9660823.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    120. Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver. Biochem Pharmacol. 1998 Jul 01; 56(1):15-23. Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P. PMID: 9698084.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    121. Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos. Development. 1998 Feb; 125(3):533-44. Ruiz-Lozano P, Smith SM, Perkins G, Kubalak SW, Boss GR, Sucov HM, Evans RM, Chien KR. PMID: 9425147.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    122. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene. 1997 Dec 04; 15(23):2755-65. Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. PMID: 9419966.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    123. A low molecular weight substance purified from human placenta inhibits cAMP-dependent protein kinase and activates protein kinase C. Mol Cell Biochem. 1997 May; 170(1-2):75-83. Talwar N, Pilz RB, Yu Z, Burlingame A, Boss GR. PMID: 9144320.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    124. A decrease in the intracellular guanosine 5'-triphosphate concentration is necessary for granulocytic differentiation of HL-60 cells, but growth cessation and differentiation are not associated with a change in the activation state of Ras, the transforming principle of HL-60 cells. Cell Growth Differ. 1997 Jan; 8(1):53-9. Pilz RB, Huvar I, Scheele JS, Van den Berghe G, Boss GR. PMID: 8993834.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    125. Regional deficits of myocardial blood flow and function in left ventricular pacing-induced heart failure. Circulation. 1996 Nov 01; 94(9):2260-7. Helmer GA, McKirnan MD, Shabetai R, Boss GR, Ross J, Hammond HK. PMID: 8901681.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    126. Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway. J Biol Chem. 1996 Oct 11; 271(41):25639-45. Prigent SA, Nagane M, Lin H, Huvar I, Boss GR, Feramisco JR, Cavenee WK, Huang HS. PMID: 8810340.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    127. Is clinical subspecialty training necessary to become a physician-scientist? J Investig Med. 1996 Apr; 44(4):136-8. Boss GR. PMID: 8689408.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    128. Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter. J Biol Chem. 1996 Mar 01; 271(9):4597-600. Gudi T, Huvar I, Meinecke M, Lohmann SM, Boss GR, Pilz RB. PMID: 8617718.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    129. Ras-GTP levels are elevated in human NF1 peripheral nerve tumors. Oncogene. 1996 Feb 01; 12(3):507-13. Guha A, Lau N, Huvar I, Gutmann D, Provias J, Pawson T, Boss G. PMID: 8637706.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    130. Nitric oxide-releasing agents and cGMP analogues inhibit murine erythroleukemia cell differentiation and suppress erythroid-specific gene expression: correlation with decreased DNA binding of NF-E2 and altered c-myb mRNA expression. Cell Growth Differ. 1995 Dec; 6(12):1559-66. Suhasini M, Boss GR, Pascual FE, Pilz RB. PMID: 9019161.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    131. Nitric oxide and cGMP analogs activate transcription from AP-1-responsive promoters in mammalian cells. FASEB J. 1995 Apr; 9(7):552-8. Pilz RB, Suhasini M, Idriss S, Meinkoth JL, Boss GR. PMID: 7737465.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    132. Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):1097-100. Scheele JS, Rhee JM, Boss GR. PMID: 7862641.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    133. Isolation and characterization of HL-60 cells resistant to nitroprusside-induced differentiation. J Biol Chem. 1994 Dec 23; 269(51):32155-61. Pilz RB, Berjis M, Idriss SD, Scheele JS, Suhasini M, Gao L, Scheffler IE, Boss GR. PMID: 7798212.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    134. Identification of a ras-related protein in murine erythroleukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induced differentiation. J Biol Chem. 1994 Jul 15; 269(28):18599-606. Scheele JS, Pilz RB, Quilliam LA, Boss GR. PMID: 8034608.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    135. Microinjection of an nm23 specific antibody inhibits cell division in rat embryo fibroblasts. Biochem Biophys Res Commun. 1993 Aug 31; 195(1):336-45. Sorscher SM, Steeg P, Feramisco JR, Buckmaster C, Boss GR, Meinkoth J. PMID: 8395830.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    136. Chemically induced murine erythroleukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes. J Biol Chem. 1992 Aug 15; 267(23):16161-7. Pilz RB, Eigenthaler M, Boss GR. PMID: 1644803.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    137. Enzymic hydrolysis of nicotinate esters: comparison between plasma and liver catalysis. Xenobiotica. 1992 Mar; 22(3):273-82. Durrer A, Wernly-Chung GN, Boss G, Testa B. PMID: 1496819.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    138. Studies on cytosolic guanylate cyclase from human placenta. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):312-20. Idriss SD, Pilz RB, Sharma VS, Boss GR. PMID: 1347448.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    139. Double-mixing kinetic studies of the reactions of monoliganded species of hemoglobin: alpha 2(CO)1 beta 2 and alpha 2 beta 2(CO)1. J Biol Chem. 1991 Dec 25; 266(36):24492-7. Sharma VS, Bandyopadhyay D, Berjis M, Rifkind J, Boss GR. PMID: 1761549.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    140. The evolution of lymphadenopathy and hypergammaglobulinemia are evidence for early and sustained polyclonal B lymphocyte activation during human immunodeficiency virus infection. J Infect Dis. 1991 Feb; 163(2):240-6. Jacobson DL, McCutchan JA, Spechko PL, Abramson I, Smith RS, Bartok A, Boss GR, Durand D, Bozzette SA, Spector SA. PMID: 1671053.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    141. Inotropic interventions during myocardial "stunning" in the pig. Am J Cardiovasc Pathol. 1990; 3(3):225-36. White FC, Boss G. PMID: 2095829.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    142. Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989 Nov 15; 38(22):4045-51. Moore EC, Hurlbert RB, Boss GR, Massia SP. PMID: 2480792.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    143. cGMP-induced differentiation of the promyelocytic cell line HL-60. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7174-8. Boss GR. PMID: 2550930.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    144. Adenosine dialdehyde and nitrous oxide induce HL-60 differentiation. Blood. 1987 Oct; 70(4):1161-4. Pilz RB, Van den Berghe G, Boss GR. PMID: 3651602.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    145. Purine deoxynucleosides and adenosine dialdehyde decrease 5-amino-4-imidazolecarboxamide (Z-base)-dependent purine nucleotide synthesis in cultured T and B lymphoblasts. Biochem J. 1987 Mar 01; 242(2):425-31. Boss GR. PMID: 3109390.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    146. Induction of HL-60 differentiation by starvation for a single essential amino acid but not by protein synthesis inhibitors. J Clin Invest. 1987 Mar; 79(3):1006-9. Pilz RB, Van den Berghe G, Boss GR. PMID: 3469216.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    147. The synthesis of phosphoribosylpyrophosphate from glucose decreases during amino acid starvation of human lymphoblasts. Adv Exp Med Biol. 1986; 195 Pt B:611-4. Pilz RB, Boss GR. PMID: 2429513.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    148. Cobalamin inactivation decreases purine and methionine synthesis in cultured human lymphoblasts. Adv Exp Med Biol. 1986; 195 Pt B:639-41. Boss GR. PMID: 3094331.
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    149. Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts. J Clin Invest. 1985 Jul; 76(1):213-8. Boss GR. PMID: 2862163.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    150. Phosphoribosylpyrophosphate synthesis from glucose decreases during amino acid starvation of human lymphoblasts. J Biol Chem. 1985 May 25; 260(10):6054-9. Boss GR, Pilz RB. PMID: 2581946.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    151. Decreased methionine synthesis in purine nucleoside-treated T and B lymphoblasts and reversal by homocysteine. J Clin Invest. 1984 Oct; 74(4):1262-8. Boss GR, Pilz RB. PMID: 6332827.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    152. Decreased phosphoribosylpyrophosphate as the basis for decreased purine synthesis during amino acid starvation of human lymphoblasts. J Biol Chem. 1984 Mar 10; 259(5):2936-41. Boss GR. PMID: 6199353.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    153. The influence of ribose 5-phosphate availability on purine synthesis of cultured human lymphoblasts and mitogen-stimulated lymphocytes. J Biol Chem. 1984 Mar 10; 259(5):2927-35. Pilz RB, Willis RC, Boss GR. PMID: 6699001.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    154. Synthesis of (14C)-ribose-5-phosphate and (14C)-phosphoribosylpyrophosphate and their use in new enzyme assays. Adv Exp Med Biol. 1984; 165 Pt B:11-3. Boss GR, Idriss SD, Willis RC, Seegmiller JE. PMID: 6202119.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    155. Purine synthesis during amino acid starvation of lymphoblasts with HPRT deficiency or PP-ribose-P synthetase overactivity decreases less than in normal cells. Adv Exp Med Biol. 1984; 165 Pt B:15-9. Boss GR. PMID: 6326498.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    156. Assay of glutamine phosphoribosylpyrophosphate amidotransferase using [1-14C]phosphoribosylpyrophosphate. Anal Biochem. 1983 Apr 01; 130(1):283-6. Boss GR, Idriss SD, Willis RC, Seegmiller JE. PMID: 6191593.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    157. Decreased purine synthesis during amino acid starvation of human lymphoblasts. J Biol Chem. 1982 Apr 25; 257(8):4242-7. Boss GR, Erbe RW. PMID: 6279630.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    158. Decreased rates of methionine synthesis by methylene tetrahydrofolate reductase-deficient fibroblasts and lymphoblasts. J Clin Invest. 1981 Jun; 67(6):1659-64. Boss GR, Erbe RW. PMID: 6113252.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    159. Ecto-5'-nucleotidase deficiency: association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity. Clin Immunol Immunopathol. 1981 Apr; 19(1):1-7. Boss GR, Thompson LF, O'Connor RD, Ziering RW, Seegmiller JE. PMID: 6260402.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    160. Age-dependency of lymphocyte ecto-5'-nucleotidase activity. J Immunol. 1980 Aug; 125(2):679-82. Boss GR, Thompson LF, Spiegelberg HL, Pichler WJ, Seegmiller JE. PMID: 6248594.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    161. Ecto-5'-nucleotidase activity in lymphoblastoid cell lines derived from heterozygotes for congenital X-linked agammaglobulinemia. J Immunol. 1980 Jul; 125(1):190-3. Thompson LF, Boss GR, Spiegelberg HL, Bianchino A, Seegmiller JE. PMID: 6247393.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    162. Thymidine requirements for the rescue of patients treated with high-dose methotrexate. Cancer Res. 1980 Jun; 40(6):1824-9. Howell SB, Herbst K, Boss GR, Frei E. PMID: 7371013.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    163. Ecto-5'-nucleotidase activity in T and B lymphocytes from normal subjects and patients with congenital X-linked agammaglobulinemia. J Immunol. 1979 Dec; 123(6):2475-8. Thompson LF, Boss GR, Spiegelberg HL, Jansen IV, O'Connor RD, Waldmann TA, Hamburger RN, Seegmiller JE. PMID: 315423.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    164. Activity of ecto-5'-nucleotidase in lymphoblastoid cell lines derived from carriers of congenital X-linked agammaglobulinemia. Adv Exp Med Biol. 1979; 122B:327-32. Thompson LF, Boss GR, Bianchino A, Seegmiller JE. PMID: 232636.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    165. Lymphocyte ecto-5'-nucleotidase activity as a marker of B-cell maturation. Trans Assoc Am Physicians. 1979; 92:309-15. Boss GR, Thompson LF, Spiegelberg HL, Waldmann TA, O'Connor RD, Hamburger RN, Seegmiller JE. PMID: 232944.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
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