Karen Christman

Title(s)Professor, Bioengineering
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Pathways underlying recovery of injured urethral sphincter and a novel regenerative biomaterial intervention
    NIH R01DK128639Jul 15, 2021 - Apr 30, 2025
    Role: Co-Principal Investigator
    Prevention of pelvic floor muscle dysfunction with extracellular matrix hydrogel
    NIH R01HD102184Sep 30, 2020 - Jun 30, 2025
    Role: Co-Principal Investigator
    New infusible ECM hydrogel for treating acute myocardial infarction
    NIH R43HL150917May 20, 2020 - Apr 30, 2021
    Role: Co-Principal Investigator
    Injectable Biomaterial for Treating Hypoplastic Left Heart Syndrome
    NIH R01HL146147Jan 1, 2019 - Dec 31, 2022
    Role: Co-Principal Investigator
    Promotion of Skeletal Muscle Recovery Using an Extracellular Matrix Hydrogel in a Rabbit Model of Chronic Rotator Cuff Injury
    NIH R21AR072523Mar 7, 2018 - Dec 31, 2019
    Role: Co-Principal Investigator
    Injectable Tissue-Specific Extracellular Matrix Hydrogel for Pelvic Skeletal Muscle Regeneration Following Birth Injury
    NIH R21HD094566Dec 1, 2017 - Nov 30, 2020
    Role: Co-Principal Investigator
    MMP Responsive Nanoparticles for Treating Acute Myocardial Infarction
    NIH R01HL139001Sep 1, 2017 - Aug 31, 2021
    Role: Principal Investigator
    A 3-D biomimetic human islet to model beta cell function in health and disease
    NIH UC4DK104202Sep 20, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction
    NIH R01HL117326Sep 20, 2012 - May 31, 2018
    Role: Principal Investigator
    Extracellular Matrix Hydrogels for Treating Cardiomyopathy
    NIH R01HL113468Jul 1, 2012 - Nov 30, 2021
    Role: Principal Investigator
    Percutaneous deliverable biomaterial for treating myocardial infarction
    NIH R43HL108459Sep 1, 2011 - Aug 31, 2012
    Role: Principal Investigator
    Phase II: Percutaneous deliverable biomaterial for treating myocardial infarction
    NIH R44HL108459Mar 1, 2011 - May 31, 2015
    Role: Principal Investigator
    Enhanced cardiomyocyte differentiation and maturation using myocardial matrix
    NIH R21HL104493Jul 15, 2010 - Jun 30, 2012
    Role: Principal Investigator
    Engineering a Dynamic Extracellular Matrix Microenvironment
    NIH DP2OD004309Sep 30, 2008 - Aug 31, 2013
    Role: Principal Investigator
    Selective patterning of biomolecules into protein arrays
    NIH F32HL082138Aug 1, 2005 - Jul 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Myocardial Matrix Hydrogels Mitigate Negative Remodeling and Improve Function in Right Heart Failure Model. JACC Basic Transl Sci. 2024 Mar; 9(3):322-338. Hunter JD, Mesfin JM, Ahmed T, Chen A, Reimold K, Hancko A, Braden RL, Davis ME, Christman KL. PMID: 38559631; PMCID: PMC10978413.
      View in: PubMed   Mentions:
    2. A vascularized 3D model of the human pancreatic islet forex vivostudy of immune cell-islet interaction. Biofabrication. 2024 Jan 11; 16(2). Bender RHF, O'Donnell BT, Shergill B, Pham BQ, Tahmouresie S, Sanchez CN, Juat DJ, Hatch MMS, Shirure VS, Wortham M, Nguyen-Ngoc KV, Jun Y, Gaetani R, Christman KL, Teyton L, George SC, Sander M, Hughes CCW. PMID: 38128127; PMCID: PMC10782895.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Immunomodulatory contribution of mast cells to the regenerative biomaterial microenvironment. NPJ Regen Med. 2023 Sep 20; 8(1):53. Wang RM, Mesfin JM, Karkanitsa M, Ungerleider JL, Zelus E, Zhang Y, Kawakami Y, Kawakami Y, Kawakami T, Christman KL. PMID: 37730736; PMCID: PMC10511634.
      View in: PubMed   Mentions:
    4. Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to Acute Myocardial Infarction. Biomacromolecules. 2023 11 13; 24(11):4695-4704. Sullivan HL, Liang Y, Worthington K, Luo C, Gianneschi NC, Christman KL. PMID: 37695847; PMCID: PMC10646957.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Extracellular Matrix Biomaterial Therapy for Myocardial Infarction: New Delivery Route and Immunomodulatory Effects. JACC Basic Transl Sci. 2023 Aug; 8(8):955-957. Christman KL. PMID: 37719431; PMCID: PMC10504395.
      View in: PubMed   Mentions:
    6. Proregenerative extracellular matrix hydrogel mitigates pathological alterations of pelvic skeletal muscles after birth injury. Sci Transl Med. 2023 08 02; 15(707):eabj3138. Duran P, Boscolo Sesillo F, Cook M, Burnett L, Menefee SA, Do E, French S, Zazueta-Damian G, Dzieciatkowska M, Saviola AJ, Shah MM, Sanvictores C, Osborn KG, Hansen KC, Shtrahman M, Christman KL, Alperin M. PMID: 37531414; PMCID: PMC10460616.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Equitable hiring strategies towards a diversified faculty. Nat Biomed Eng. 2023 08; 7(8):961-968. Cosgriff-Hernandez EM, Aguado BA, Akpa B, Fleming GC, Moore E, Porras AM, Boyle PM, Chan DD, Chesler N, Christman KL, Desai TA, Harley BAC, Hudalla GA, Killian ML, Maisel K, Maitland KC, Peyton SR, Pruitt BL, Stabenfeldt SE, Stevens KR, Bowden AK. PMID: 37580521.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Infusible Extracellular Matrix Biomaterial Promotes Vascular Integrity and Modulates the Inflammatory Response in Acute Traumatic Brain Injury. Adv Healthc Mater. 2023 Oct; 12(25):e2300782. Diaz MD, Kandell RM, Wu JR, Chen A, Christman KL, Kwon EJ. PMID: 37390094; PMCID: PMC10592293.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Inflammation-Responsive Micellar Nanoparticles from Degradable Polyphosphoramidates for Targeted Delivery to Myocardial Infarction. J Am Chem Soc. 2023 05 24; 145(20):11185-11194. Liang Y, Sullivan HL, Carrow K, Mesfin JM, Korpanty J, Worthington K, Luo C, Christman KL, Gianneschi NC. PMID: 37184379.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Intravascularly Deliverable Biomaterial Platforms for Tissue Repair and Regeneration Post-Myocardial Infarction. Adv Mater. 2023 Mar 29; e2300603. Chen A, Mesfin JM, Gianneschi NC, Christman KL. PMID: 36989469; PMCID: PMC10539487.
      View in: PubMed   Mentions:    Fields:    
    11. Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues. Nat Biomed Eng. 2023 02; 7(2):94-109. Spang MT, Middleton R, Diaz M, Hunter J, Mesfin J, Banka A, Sullivan H, Wang R, Lazerson TS, Bhatia S, Corbitt J, D'Elia G, Sandoval-Gomez G, Kandell R, Vratsanos MA, Gnanasekaran K, Kato T, Igata S, Luo C, Osborn KG, Gianneschi NC, Eniola-Adefeso O, Cabrales P, Kwon EJ, Contijoch F, Reeves RR, DeMaria AN, Christman KL. PMID: 36581694; PMCID: PMC10166066.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury. NPJ Regen Med. 2022 Dec 16; 7(1):72. Sesillo FB, Rajesh V, Wong M, Duran P, Rudell JB, Rundio CP, Baynes BB, Laurent LC, Sacco A, Christman KL, Alperin M. PMID: 36526635; PMCID: PMC9758192.
      View in: PubMed   Mentions: 1  
    13. Myocardial matrix hydrogel acts as a reactive oxygen species scavenger and supports a proliferative microenvironment for cardiomyocytes. Acta Biomater. 2022 10 15; 152:47-59. Wang RM, Mesfin JM, Hunter J, Cattaneo P, Guimarães-Camboa N, Braden RL, Luo C, Hill RC, Dzieciatkowska M, Hansen KC, Evans S, Christman KL. PMID: 36041648.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Characterization of decellularized left and right ventricular myocardial matrix hydrogels and their effects on cardiac progenitor cells. J Mol Cell Cardiol. 2022 Oct; 171:45-55. Hunter JD, Hancko A, Shakya P, Hill R, Saviola AJ, Hansen KC, Davis ME, Christman KL. PMID: 35780862.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. In vivo evaluation of bioprinted cardiac patches composed of cardiac-specific extracellular matrix and progenitor cells in a model of pediatric heart failure. Biomater Sci. 2022 Jan 18; 10(2):444-456. Bejleri D, Robeson MJ, Brown ME, Hunter J, Maxwell JT, Streeter BW, Brazhkina O, Park HJ, Christman KL, Davis ME. PMID: 34878443; PMCID: PMC8772587.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Injectable ECM Scaffolds for Cardiac Repair. Methods Mol Biol. 2022; 2485:255-268. Hunter JD, Johnson TD, Braden RL, Christman KL. PMID: 35618911.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel. Nat Commun. 2021 06 18; 12(1):3764. Fujita M, Policastro GM, Burdick A, Lam HT, Ungerleider JL, Braden RL, Huang D, Osborn KG, Omens JH, Madani MM, Christman KL. PMID: 34145265; PMCID: PMC8213776.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    18. Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model. JACC Basic Transl Sci. 2021 Apr; 6(4):350-361. Diaz MD, Tran E, Spang M, Wang R, Gaetani R, Luo CG, Braden R, Hill RC, Hansen KC, DeMaria AN, Christman KL. PMID: 33997521; PMCID: PMC8093531.
      View in: PubMed   Mentions: 14  
    19. Quantifying the Effects of Aging on Morphological and Cellular Properties of Human Female Pelvic Floor Muscles. Ann Biomed Eng. 2021 Aug; 49(8):1836-1847. Rieger M, Duran P, Cook M, Schenk S, Shah M, Jacobs M, Christman K, Kado DM, Alperin M. PMID: 33683527; PMCID: PMC8376748.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Fund Black scientists. Cell. 2021 02 04; 184(3):561-565. Stevens KR, Masters KS, Imoukhuede PI, Haynes KA, Setton LA, Cosgriff-Hernandez E, Lediju Bell MA, Rangamani P, Sakiyama-Elbert SE, Finley SD, Willits RK, Koppes AN, Chesler NC, Christman KL, Allen JB, Wong JY, El-Samad H, Desai TA, Eniola-Adefeso O. PMID: 33503447.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    21. Targeted nanoscale therapeutics for myocardial infarction. Biomater Sci. 2021 Feb 21; 9(4):1204-1216. Sullivan HL, Gianneschi NC, Christman KL. PMID: 33367371; PMCID: PMC7932032.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Dose optimization of decellularized skeletal muscle extracellular matrix hydrogels for improving perfusion and subsequent validation in an aged hindlimb ischemia model. Biomater Sci. 2020 Jun 21; 8(12):3511-3521. Hernandez MJ, Zelus EI, Spang MT, Braden RL, Christman KL. PMID: 32432574; PMCID: PMC7375022.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Manufacturing considerations for producing and assessing decellularized extracellular matrix hydrogels. Methods. 2020 01 15; 171:20-27. Hernandez MJ, Yakutis GE, Zelus EI, Hill RC, Dzieciatkowska M, Hansen KC, Christman KL. PMID: 31546012.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    24. First-in-Man Study of a Cardiac Extracellular Matrix Hydrogel in Early and Late Myocardial Infarction Patients. JACC Basic Transl Sci. 2019 Oct; 4(6):659-669. Traverse JH, Henry TD, Dib N, Patel AN, Pepine C, Schaer GL, DeQuach JA, Kinsey AM, Chamberlin P, Christman KL. PMID: 31709316; PMCID: PMC6834965.
      View in: PubMed   Mentions: 95  
    25. Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction. Nat Commun. 2019 04 15; 10(1):1735. Carlini AS, Gaetani R, Braden RL, Luo C, Christman KL, Gianneschi NC. PMID: 30988291; PMCID: PMC6465301.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    26. Mechanical impact of parturition-related strains on rat pelvic striated sphincters. Neurourol Urodyn. 2019 03; 38(3):912-919. Duran P, Ward S, Christman KL, Alperin M. PMID: 30779377; PMCID: PMC6431564.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    27. Multimodal imaging assessment and histologic correlation of the female rat pelvic floor muscles' anatomy. J Anat. 2019 04; 234(4):543-550. Sheth VR, Duran P, Wong J, Shah S, Du J, Christman KL, Chang EY, Alperin M. PMID: 30740685; PMCID: PMC6422690.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    28. Biomaterials for tissue repair. Science. 2019 01 25; 363(6425):340-341. Christman KL. PMID: 30679357; PMCID: PMC6697375.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    29. Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels. Tissue Eng Part C Methods. 2018 12; 24(12):697-708. Gaetani R, Aude S, DeMaddalena LL, Strassle H, Dzieciatkowska M, Wortham M, Bender RHF, Nguyen-Ngoc KV, Schmid-Schöenbein GW, George SC, Hughes CCW, Sander M, Hansen KC, Christman KL. PMID: 30398401; PMCID: PMC6306687.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    30. A Bioprinted Cardiac Patch Composed of Cardiac-Specific Extracellular Matrix and Progenitor Cells for Heart Repair. Adv Healthc Mater. 2018 12; 7(23):e1800672. Bejleri D, Streeter BW, Nachlas ALY, Brown ME, Gaetani R, Christman KL, Davis ME. PMID: 30379414; PMCID: PMC6521871.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    31. Decellularized Extracellular Matrix Hydrogels as a Delivery Platform for MicroRNA and Extracellular Vesicle Therapeutics. Adv Ther (Weinh). 2018 Jul; 1(3). Hernandez MJ, Gaetani R, Pieters VM, Ng NW, Chang AE, Martin TR, van Ingen E, Mol EA, Sluijter JPG, Christman KL. PMID: 31544132; PMCID: PMC6753838.
      View in: PubMed   Mentions: 12  
    32. Extracellular matrix hydrogel therapies: In vivo applications and development. Acta Biomater. 2018 03 01; 68:1-14. Spang MT, Christman KL. PMID: 29274480; PMCID: PMC5857190.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    33. Self-Assembled Colloidal Gel Using Cell Membrane-Coated Nanosponges as Building Blocks. ACS Nano. 2017 12 26; 11(12):11923-11930. Zhang Y, Gao W, Chen Y, Escajadillo T, Ungerleider J, Fang RH, Christman K, Nizet V, Zhang L. PMID: 29116753; PMCID: PMC6336496.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    34. Enzyme-Targeted Nanoparticles for Delivery to Ischemic Skeletal Muscle. Polym Chem. 2017 Sep 14; 8(34):5212-5219. Ungerleider JL, Kammeyer JK, Braden RL, Christman KL, Gianneschi NC. PMID: 29098018; PMCID: PMC5662209.
      View in: PubMed   Mentions: 7  
    35. Designing Acellular Injectable Biomaterial Therapeutics for Treating Myocardial Infarction and Peripheral Artery Disease. JACC Basic Transl Sci. 2017 Apr; 2(2):212-226. Hernandez MJ, Christman KL. PMID: 29057375; PMCID: PMC5646282.
      View in: PubMed   Mentions: 28  
    36. Engineering an Injectable Muscle-Specific Microenvironment for Improved Cell Delivery Using a Nanofibrous Extracellular Matrix Hydrogel. ACS Nano. 2017 04 25; 11(4):3851-3859. Rao N, Agmon G, Tierney MT, Ungerleider JL, Braden RL, Sacco A, Christman KL. PMID: 28323411; PMCID: PMC5576867.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    37. Humanized mouse model for assessing the human immune response to xenogeneic and allogeneic decellularized biomaterials. Biomaterials. 2017 06; 129:98-110. Wang RM, Johnson TD, He J, Rong Z, Wong M, Nigam V, Behfar A, Xu Y, Christman KL. PMID: 28334641; PMCID: PMC5434867.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    38. Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro. Stem Cells Int. 2016; 2016:8364382. French KM, Maxwell JT, Bhutani S, Ghosh-Choudhary S, Fierro MJ, Johnson TD, Christman KL, Taylor WR, Davis ME. PMID: 27610140; PMCID: PMC5004015.
      View in: PubMed   Mentions: 15  
    39. Controlling stem cell behavior with decellularized extracellular matrix scaffolds. Curr Opin Solid State Mater Sci. 2016 Aug; 20(4):193-201. Agmon G, Christman KL. PMID: 27524932; PMCID: PMC4979580.
      View in: PubMed   Mentions: 55  
    40. Modulating In Vivo Degradation Rate of Injectable Extracellular Matrix Hydrogels. J Mater Chem B. 2016 Apr 28; 4(16):2794-2802. Wassenaar JW, Braden RL, Osborn KG, Christman KL. PMID: 27563436; PMCID: PMC4993464.
      View in: PubMed   Mentions: 28     Fields:    
    41. Evidence for Mechanisms Underlying the Functional Benefits of a Myocardial Matrix Hydrogel for Post-MI Treatment. J Am Coll Cardiol. 2016 Mar 08; 67(9):1074-1086. Wassenaar JW, Gaetani R, Garcia JJ, Braden RL, Luo CG, Huang D, DeMaria AN, Omens JH, Christman KL. PMID: 26940929; PMCID: PMC4779189.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    42. Extracellular Matrix Hydrogel Promotes Tissue Remodeling, Arteriogenesis, and Perfusion in a Rat Hindlimb Ischemia Model. JACC Basic Transl Sci. 2016 Jan-Feb; 1(1-2):32-44. Ungerleider JL, Johnson TD, Hernandez MJ, Elhag DI, Braden RL, Dzieciatkowska M, Osborn KG, Hansen KC, Mahmud E, Christman KL. PMID: 27104218; PMCID: PMC4834896.
      View in: PubMed   Mentions: 41  
    43. Degradable acetalated dextran microparticles for tunable release of an engineered hepatocyte growth factor fragment. ACS Biomater Sci Eng. 2016 Feb 08; 2(2):197-204. Suarez SL, Muñoz A, Mitchell A, Braden RL, Luo C, Cochran JR, Almutairi A, Christman KL. PMID: 29333489; PMCID: PMC5761072.
      View in: PubMed   Mentions: 10     Fields:    
    44. Cardiac-Derived Extracellular Matrix Enhances Cardiogenic Properties of Human Cardiac Progenitor Cells. Cell Transplant. 2016; 25(9):1653-1663. Gaetani R, Yin C, Srikumar N, Braden R, Doevendans PA, Sluijter JP, Christman KL. PMID: 26572770.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    45. Quantification of decellularized human myocardial matrix: A comparison of six patients. Proteomics Clin Appl. 2016 Jan; 10(1):75-83. Johnson TD, Hill RC, Dzieciatkowska M, Nigam V, Behfar A, Christman KL, Hansen KC. PMID: 26172914; PMCID: PMC4703489.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    46. Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction. Adv Mater. 2015 Oct 07; 27(37):5547-52. Nguyen MM, Carlini AS, Chien MP, Sonnenberg S, Luo C, Braden RL, Osborn KG, Li Y, Gianneschi NC, Christman KL. PMID: 26305446; PMCID: PMC4699559.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    47. Intramyocardial injection of hydrogel with high interstitial spread does not impact action potential propagation. Acta Biomater. 2015 Oct; 26:13-22. Suarez SL, Rane AA, Muñoz A, Wright AT, Zhang SX, Braden RL, Almutairi A, McCulloch AD, Christman KL. PMID: 26265060; PMCID: PMC4772723.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    48. Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials. 2015 Sep; 64:108-14. Wassenaar JW, Boss GR, Christman KL. PMID: 26125502; PMCID: PMC4506649.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    49. Decellularized myocardial matrix hydrogels: In basic research and preclinical studies. Adv Drug Deliv Rev. 2016 Jan 15; 96:77-82. Wang RM, Christman KL. PMID: 26056717; PMCID: PMC4670814.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    50. Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components. Tissue Eng Part A. 2015 Aug; 21(15-16):2195-205. Merna N, Fung KM, Wang JJ, King CR, Hansen KC, Christman KL, George SC. PMID: 25926101; PMCID: PMC4528988.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    51. Epicardial application of cardiac progenitor cells in a 3D-printed gelatin/hyaluronic acid patch preserves cardiac function after myocardial infarction. Biomaterials. 2015 Aug; 61:339-48. Gaetani R, Feyen DA, Verhage V, Slaats R, Messina E, Christman KL, Giacomello A, Doevendans PA, Sluijter JP. PMID: 26043062.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    52. Binding of Anticell Adhesive Oxime-Crosslinked PEG Hydrogels to Cardiac Tissues. Adv Healthc Mater. 2015 Jun 24; 4(9):1327-31. Grover GN, Garcia J, Nguyen MM, Zanotelli M, Madani MM, Christman KL. PMID: 25963916; PMCID: PMC5812365.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    53. Developing injectable nanomaterials to repair the heart. Curr Opin Biotechnol. 2015 Aug; 34:225-31. Nguyen MM, Gianneschi NC, Christman KL. PMID: 25863496; PMCID: PMC4555187.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    54. Fabrication and characterization of injectable hydrogels derived from decellularized skeletal and cardiac muscle. Methods. 2015 Aug; 84:53-9. Ungerleider JL, Johnson TD, Rao N, Christman KL. PMID: 25843605; PMCID: PMC4526417.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    55. Micro- and Nanoparticles for Treating Cardiovascular Disease. Biomater Sci. 2015 Apr; 3(4):564-80. Suarez S, Almutairi A, Christman KL. PMID: 26146548; PMCID: PMC4486363.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    56. Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction. Biomaterials. 2015 Mar; 45:56-63. Sonnenberg SB, Rane AA, Liu CJ, Rao N, Agmon G, Suarez S, Wang R, Munoz A, Bajaj V, Zhang S, Braden R, Schup-Magoffin PJ, Kwan OL, DeMaria AN, Cochran JR, Christman KL. PMID: 25662495; PMCID: PMC4326250.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    57. Concise review: injectable biomaterials for the treatment of myocardial infarction and peripheral artery disease: translational challenges and progress. Stem Cells Transl Med. 2014 Sep; 3(9):1090-9. Ungerleider JL, Christman KL. PMID: 25015641; PMCID: PMC4149304.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    58. Award winner for outstanding research in the PhD category, 2014 Society for Biomaterials annual meeting and exposition, Denver, Colorado, April 16-19, 2014: Decellularized adipose matrix hydrogels stimulate in vivo neovascularization and adipose formation. J Biomed Mater Res A. 2014 Jun; 102(6):1641-51. Adam Young D, Bajaj V, Christman KL. PMID: 24510423.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    59. Human versus porcine tissue sourcing for an injectable myocardial matrix hydrogel. Biomater Sci. 2014; 2014:60283D. Johnson TD, Dequach JA, Gaetani R, Ungerleider J, Elhag D, Nigam V, Behfar A, Christman KL. PMID: 24634775; PMCID: PMC3950205.
      View in: PubMed   Mentions: 50     Fields:    
    60. Injectable ECM scaffolds for cardiac repair. Methods Mol Biol. 2014; 1181:109-20. Johnson TD, Braden RL, Christman KL. PMID: 25070331; PMCID: PMC4374640.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    61. Myocardial matrix-polyethylene glycol hybrid hydrogels for tissue engineering. Nanotechnology. 2014 Jan 10; 25(1):014011. Grover GN, Rao N, Christman KL. PMID: 24334615; PMCID: PMC3914302.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    62. Tunable protein release from acetalated dextran microparticles: a platform for delivery of protein therapeutics to the heart post-MI. Biomacromolecules. 2013 Nov 11; 14(11):3927-35. Suarez S, Grover GN, Braden RL, Christman KL, Almutairi A. PMID: 24053580; PMCID: PMC3910395.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    63. A co-culture device with a tunable stiffness to understand combinatorial cell-cell and cell-matrix interactions. Integr Biol (Camb). 2013 Nov; 5(11):1344-54. Rao N, Grover GN, Vincent LG, Evans SC, Choi YS, Spencer KH, Hui EE, Engler AJ, Christman KL. PMID: 24061208; PMCID: PMC3848881.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    64. Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue. Biomaterials. 2013 Nov; 34(34):8581-8. Young DA, Choi YS, Engler AJ, Christman KL. PMID: 23953825; PMCID: PMC3786695.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    65. Materials science and tissue engineering: repairing the heart. Mayo Clin Proc. 2013 Aug; 88(8):884-98. Radisic M, Christman KL. PMID: 23910415; PMCID: PMC3786696.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    66. In vivo response to dynamic hyaluronic acid hydrogels. Acta Biomater. 2013 Jul; 9(7):7151-7. Young JL, Tuler J, Braden R, Schüp-Magoffin P, Schaefer J, Kretchmer K, Christman KL, Engler AJ. PMID: 23523533; PMCID: PMC3674107.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    67. Oxime cross-linked injectable hydrogels for catheter delivery. Adv Mater. 2013 Jun 04; 25(21):2937-42. Grover GN, Braden RL, Christman KL. PMID: 23495015; PMCID: PMC3884068.
      View in: PubMed   Mentions: 30     Fields:    
    68. Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction. Sci Transl Med. 2013 Feb 20; 5(173):173ra25. Seif-Naraghi SB, Singelyn JM, Salvatore MA, Osborn KG, Wang JJ, Sampat U, Kwan OL, Strachan GM, Wong J, Schup-Magoffin PJ, Braden RL, Bartels K, DeQuach JA, Preul M, Kinsey AM, DeMaria AN, Dib N, Christman KL. PMID: 23427245; PMCID: PMC3848875.
      View in: PubMed   Mentions: 180     Fields:    Translation:AnimalsCells
    69. Fibroblasts influence muscle progenitor differentiation and alignment in contact independent and dependent manners in organized co-culture devices. Biomed Microdevices. 2013 Feb; 15(1):161-9. Rao N, Evans S, Stewart D, Spencer KH, Sheikh F, Hui EE, Christman KL. PMID: 22983793; PMCID: PMC3537877.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    70. Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction. Expert Opin Drug Deliv. 2013 Jan; 10(1):59-72. Johnson TD, Christman KL. PMID: 23140533.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    71. Treating the leading killer. Sci Transl Med. 2012 Aug 08; 4(146):146fs26. Christman KL. PMID: 22875825.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    72. A naturally derived cardiac extracellular matrix enhances cardiac progenitor cell behavior in vitro. Acta Biomater. 2012 Dec; 8(12):4357-64. French KM, Boopathy AV, DeQuach JA, Chingozha L, Lu H, Christman KL, Davis ME. PMID: 22842035; PMCID: PMC3488121.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    73. Injectable extracellular matrix derived hydrogel provides a platform for enhanced retention and delivery of a heparin-binding growth factor. Acta Biomater. 2012 Oct; 8(10):3695-703. Seif-Naraghi SB, Horn D, Schup-Magoffin PJ, Christman KL. PMID: 22750737; PMCID: PMC3429632.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    74. Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model. Eur Cell Mater. 2012 Jun 05; 23:400-12; discussion 412. DeQuach JA, Lin JE, Cam C, Hu D, Salvatore MA, Sheikh F, Christman KL. PMID: 22665162; PMCID: PMC3524267.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    75. Injectable biomaterials for adipose tissue engineering. Biomed Mater. 2012 Apr; 7(2):024104. Young DA, Christman KL. PMID: 22456805; PMCID: PMC3389522.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    76. Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. J Am Coll Cardiol. 2012 Feb 21; 59(8):751-63. Singelyn JM, Sundaramurthy P, Johnson TD, Schup-Magoffin PJ, Hu DP, Faulk DM, Wang J, Mayle KM, Bartels K, Salvatore M, Kinsey AM, Demaria AN, Dib N, Christman KL. PMID: 22340268; PMCID: PMC3285410.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    77. Biomaterials for the treatment of myocardial infarction: a 5-year update. J Am Coll Cardiol. 2011 Dec 13; 58(25):2615-29. Rane AA, Christman KL. PMID: 22152947.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    78. Tailoring material properties of a nanofibrous extracellular matrix derived hydrogel. Nanotechnology. 2011 Dec 09; 22(49):494015. Johnson TD, Lin SY, Christman KL. PMID: 22101810; PMCID: PMC3280097.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    79. Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng Part A. 2011 Nov; 17(21-22):2583-92. DeQuach JA, Yuan SH, Goldstein LS, Christman KL. PMID: 21883047; PMCID: PMC3204197.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    80. Antibacterial and cell-adhesive polypeptide and poly(ethylene glycol) hydrogel as a potential scaffold for wound healing. Acta Biomater. 2012 Jan; 8(1):41-50. Song A, Rane AA, Christman KL. PMID: 22023748; PMCID: PMC3226862.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    81. Increased infarct wall thickness by a bio-inert material is insufficient to prevent negative left ventricular remodeling after myocardial infarction. PLoS One. 2011; 6(6):e21571. Rane AA, Chuang JS, Shah A, Hu DP, Dalton ND, Gu Y, Peterson KL, Omens JH, Christman KL. PMID: 21731777; PMCID: PMC3121880.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    82. Patient-to-patient variability in autologous pericardial matrix scaffolds for cardiac repair. J Cardiovasc Transl Res. 2011 Oct; 4(5):545-56. Seif-Naraghi SB, Horn D, Schup-Magoffin PA, Madani MM, Christman KL. PMID: 21695575; PMCID: PMC3280922.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    83. Modulation of material properties of a decellularized myocardial matrix scaffold. Macromol Biosci. 2011 Jun 14; 11(6):731-8. Singelyn JM, Christman KL. PMID: 21322109; PMCID: PMC3280095.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    84. Human cardiomyogenesis and the need for systems biology analysis. Wiley Interdiscip Rev Syst Biol Med. 2011 Nov-Dec; 3(6):666-80. Young DA, DeQuach JA, Christman KL. PMID: 21197666; PMCID: PMC3282989.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    85. Protein nanopatterns by oxime bond formation. Langmuir. 2011 Feb 15; 27(4):1415-8. Christman KL, Broyer RM, Schopf E, Kolodziej CM, Chen Y, Maynard HD. PMID: 21192671; PMCID: PMC3050016.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    86. Fabrication of biologically derived injectable materials for myocardial tissue engineering. J Vis Exp. 2010 Dec 20; (46). Seif-Naraghi S, Singelyn J, Dequach J, Schup-Magoffin P, Christman K. PMID: 22158083; PMCID: PMC3159653.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    87. Injectable hydrogel scaffold from decellularized human lipoaspirate. Acta Biomater. 2011 Mar; 7(3):1040-9. Young DA, Ibrahim DO, Hu D, Christman KL. PMID: 20932943; PMCID: PMC3031749.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    88. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One. 2010 Sep 27; 5(9):e13039. DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. PMID: 20885963; PMCID: PMC2946408.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    89. Injectable materials for the treatment of myocardial infarction and heart failure: the promise of decellularized matrices. J Cardiovasc Transl Res. 2010 Oct; 3(5):478-86. Singelyn JM, Christman KL. PMID: 20632221; PMCID: PMC2933811.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    90. Design and characterization of an injectable pericardial matrix gel: a potentially autologous scaffold for cardiac tissue engineering. Tissue Eng Part A. 2010 Jun; 16(6):2017-27. Seif-Naraghi SB, Salvatore MA, Schup-Magoffin PJ, Hu DP, Christman KL. PMID: 20100033; PMCID: PMC2949214.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    91. NANOPATTERNED INTERFACES FOR CONTROLLING CELL BEHAVIOR. Nano Life. 2010 Mar; 1(1-amp 2):63-77. Chung K, DeQUACH JA, Christman KL. PMID: 25383101; PMCID: PMC4221096.
      View in: PubMed   Mentions: 7  
    92. Surface patterning for generating defined nanoscale matrices. Methods Mol Biol. 2010; 660:255-63. Christman KL, Maynard HD. PMID: 20680824.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    93. Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering. Biomaterials. 2009 Oct; 30(29):5409-16. Singelyn JM, DeQuach JA, Seif-Naraghi SB, Littlefield RB, Schup-Magoffin PJ, Christman KL. PMID: 19608268; PMCID: PMC2728782.
      View in: PubMed   Mentions: 207     Fields:    Translation:AnimalsCells
    94. Positioning multiple proteins at the nanoscale with electron beam cross-linked functional polymers. J Am Chem Soc. 2009 Jan 21; 131(2):521-7. Christman KL, Schopf E, Broyer RM, Li RC, Chen Y, Maynard HD. PMID: 19160460; PMCID: PMC3050812.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    95. Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. J Thorac Cardiovasc Surg. 2009 Jan; 137(1):180-7. Yu J, Christman KL, Chin E, Sievers RE, Saeed M, Lee RJ. PMID: 19154923.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    96. Injectable myocardial matrix as a scaffold for myocardial tissue engineering. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:2406-8. Singelyn JM, DeQuach JA, Christman KL. PMID: 19964956.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    97. Nanoscale growth factor patterns by immobilization on a heparin-mimicking polymer. J Am Chem Soc. 2008 Dec 10; 130(49):16585-91. Christman KL, Vázquez-Dorbatt V, Schopf E, Kolodziej CM, Li RC, Broyer RM, Chen Y, Maynard HD. PMID: 19554729; PMCID: PMC3110987.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    98. Electrochemically controllable conjugation of proteins on surfaces. Bioconjug Chem. 2007 Nov-Dec; 18(6):1919-23. Mendes PM, Christman KL, Parthasarathy P, Schopf E, Ouyang J, Yang Y, Preece JA, Maynard HD, Chen Y, Stoddart JF. PMID: 17960874.
      View in: PubMed   Mentions: 6     Fields:    
    99. Surface initiated actin polymerization from top-down manufactured nanopatterns. Soft Matter. 2007 Apr 24; 3(5):541-546. Brough B, Christman KL, Wong TS, Kolodziej CM, Forbes JG, Wang K, Maynard HD, Ho CM. PMID: 32900015.
      View in: PubMed   Mentions: 5     Fields:    
    100. Nanopatterning proteins and peptides. Soft Matter. 2006 Oct 17; 2(11):928-939. Christman KL, Enriquez-Rios VD, Maynard HD. PMID: 32680180.
      View in: PubMed   Mentions: 33     Fields:    
    101. Biomaterials for the treatment of myocardial infarction. J Am Coll Cardiol. 2006 Sep 05; 48(5):907-13. Christman KL, Lee RJ. PMID: 16949479.
      View in: PubMed   Mentions: 121     Fields:    Translation:Humans
    102. Submicron streptavidin patterns for protein assembly. Langmuir. 2006 Aug 15; 22(17):7444-50. Christman KL, Requa MV, Enriquez-Rios VD, Ward SC, Bradley KA, Turner KL, Maynard HD. PMID: 16893251.
      View in: PubMed   Mentions: 14     Fields:    
    103. Protein micropatterns using a pH-responsive polymer and light. Langmuir. 2005 Aug 30; 21(18):8389-93. Christman KL, Maynard HD. PMID: 16114947.
      View in: PubMed   Mentions: 5     Fields:    
    104. Pleiotrophin induces formation of functional neovasculature in vivo. Biochem Biophys Res Commun. 2005 Jul 15; 332(4):1146-52. Christman KL, Fang Q, Kim AJ, Sievers RE, Fok HH, Candia AF, Colley KJ, Herradon G, Ezquerra L, Deuel TF, Lee RJ. PMID: 15949466.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    105. Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymer. Biomaterials. 2005 Apr; 26(10):1139-44. Christman KL, Fang Q, Yee MS, Johnson KR, Sievers RE, Lee RJ. PMID: 15451633.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    106. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. J Am Coll Cardiol. 2004 Aug 04; 44(3):654-60. Christman KL, Vardanian AJ, Fang Q, Sievers RE, Fok HH, Lee RJ. PMID: 15358036.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
    107. Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction. Tissue Eng. 2004 Mar-Apr; 10(3-4):403-9. Christman KL, Fok HH, Sievers RE, Fang Q, Lee RJ. PMID: 15165457.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    108. Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. Biochem Pharmacol. 2000 Nov 01; 60(9):1355-9. Stewart JR, Christman KL, O'Brian CA. PMID: 11008129.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    109. A phase I trial of a modified, dose intensive FAMTX regimen (high dose 5-fluorouracil+doxorubicin+high dose methotrexate+leucovorin) with oral uridine rescue. Cancer. 1996 Nov 01; 78(9):1988-95. Schwartz GK, Christman K, Saltz L, Casper E, Quan V, Bertino J, Martin DS, Colofiore J, Kelsen D. PMID: 8909321.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    110. Cancer chemotherapy in the elderly. J Clin Gastroenterol. 1995 Jul; 21(1):65-71. Conti JA, Christman K. PMID: 7560837.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    111. Phase II trial of gemcitabine in patients with advanced gastric cancer. Cancer. 1994 Jan 01; 73(1):5-7. Christman K, Kelsen D, Saltz L, Tarassoff PG. PMID: 8275437.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    112. Edatrexate in patients with soft tissue sarcoma. Activity in malignant fibrous histiocytoma. Cancer. 1993 Aug 01; 72(3):766-70. Casper ES, Christman KL, Schwartz GK, Johnson B, Brennan MF, Bertino JR. PMID: 8392904.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    113. Granulocyte colony-stimulating factor: effective in ameliorating fluorouracil-based myelosuppression? J Natl Cancer Inst. 1993 May 19; 85(10):826-7. Christman K, Saltz L, Schwartz G, Friedrich C, Kelsen D. PMID: 7683729.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    114. Quantitation of S-adenosylmethionine decarboxylase protein. Biochemistry. 1985 Jul 30; 24(16):4417-23. Shirahata A, Christman KL, Pegg AE. PMID: 3902085.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    115. Adolescent suicide and the classroom teacher. J Sch Health. 1980 Mar; 50(3):130-2. McKenry PC, Tishler CL, Christman KL. PMID: 6898742.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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