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Diane Simeone

Title(s)Professor, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting FSP1 triggers ferroptosis in lung cancer. bioRxiv. 2025 Aug 23. Wu K, Vaughan AJ, Bossowski JP, Hao Y, Ziogou A, Kim SM, Kim TH, Nakamura MN, Pillai R, Mancini M, Rajalingam S, Han M, Nakamura T, Wang L, Chung S, Simeone D, Shackelford D, Kang YP, Conrad M, Papagiannakopoulos T. PMID: 40832353; PMCID: PMC12363832.
      View in: PubMed   Mentions:
    2. Recurrent BEND2 Fusion Genes Identified by Whole Transcriptome Sequencing of Nonfunctional Pancreatic Neuroendocrine Tumors Correlate With Poor Patient Prognosis. Mod Pathol. 2025 Oct; 38(10):100863. Wood-Trageser MA, Nichols CT, Hutchings DA, Bell D, Wald AI, Smith K, Hong SM, Luchini C, Brosens LAA, Verschuur AVD, Bevere M, Lawlor RT, Scarpa A, Keating S, Tucker J, O'Sullivan RJ, Liu TC, McGrath K, Fasanella K, Brand RE, Lennon AM, Das R, Singh H, Slivka A, Mahmood S, Hosmer AE, Khalid A, Romutis SL, Zureikat AH, Zeh HJ, Hogg ME, Lee KK, Paniccia A, Nunns G, Ongchin M, Park WG, Polanco PM, He J, Simeone DM, Ferrone CR, Hsu D, Zhang J, Gorantla V, Rhee J, Hruban RH, Singhi AH, Singhi SA, Wang CK, Shaker N, Bubar R, Grupillo M, Lai YT, Nikiforova MN, Heaphy CM, Waters KM, Singhi AD. PMID: 40784487.
      View in: PubMed   Mentions:    Fields:    
    3. A High Performing Biomarker Signature for Detecting Early-Stage Pancreatic Ductal Adenocarcinoma in High-Risk Individuals. Cancers (Basel). 2025 Jun 02; 17(11). Palma NA, Lucas AL, Katona BW, Athanasiou A, Kureshi NM, Ford L, Keller T, Weber S, Schiess R, King T, Simeone DM, Brand R. PMID: 40507347; PMCID: PMC12153528.
      View in: PubMed   Mentions:
    4. Identification of patients at risk for pancreatic cancer in a 3-year timeframe based on machine learning algorithms. Sci Rep. 2025 Apr 05; 15(1):11697. Zhu W, Chen L, Aphinyanaphongs Y, Kastrinos F, Simeone DM, Pochapin M, Stender C, Razavian N, Gonda TA. PMID: 40188106; PMCID: PMC11972345.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression. bioRxiv. 2025 Feb 15. Kalfakakou D, Cameron DC, Kawaler EA, Tsuda M, Wang L, Jing X, Hajdu C, Tamayo DL, Shim Y, Ackermann A, Weissinger D, Zimny H, Hernandez R, Beier M, Dimartino D, Meyn P, Rice K, Selvaraj S, Loomis C, Heguy A, Lund AW, Sears RC, Welling TH, Dolgalev I, Tsirigos A, Simeone DM. PMID: 39990481; PMCID: PMC11844494.
      View in: PubMed   Mentions:
    6. Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2. Cell. 2025 Mar 20; 188(6):1642-1661.e24. Lucotti S, Ogitani Y, Kenific CM, Geri J, Kim YH, Gu J, Balaji U, Bojmar L, Shaashua L, Song Y, Cioffi M, Lauritzen P, Joseph OM, Asao T, Grandgenett PM, Hollingsworth MA, Peralta C, Pagano AE, Molina H, Lengel HB, Dunne EG, Jing X, Schmitter M, Borriello L, Miller T, Zhang H, Romin Y, Manova K, Paul D, Remmel HL, O'Reilly EM, Jarnagin WR, Kelsen D, Castellino SM, Giulino-Roth L, Jones DR, Condeelis JS, Pascual V, Bussel JB, Boudreau N, Matei I, Entenberg D, Bromberg JF, Simeone DM, Lyden D. PMID: 39938515; PMCID: PMC12452024.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    7. Longitudinal assessment of disparities in pancreatic cancer care: A retrospective analysis of the National Cancer Database. World J Surg. 2025 01; 49(1):262-269. Grewal M, Kroon VJ, Kaslow SR, Sorrentino AM, Winner MD, Allendorf JD, Shah PC, Simeone DM, Welling TH, Berman RS, Cohen SM, Wolfgang CL, Sacks GD, Javed AA. PMID: 39653505.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor. Cancer Immunol Res. 2024 Sep 03; 12(9):1221-1235. Oberstein PE, Dias Costa A, Kawaler EA, Cardot-Ruffino V, Rahma OE, Beri N, Singh H, Abrams TA, Biller LH, Cleary JM, Enzinger P, Huffman BM, McCleary NJ, Perez KJ, Rubinson DA, Schlechter BL, Surana R, Yurgelun MB, Wang SJ, Remland J, Brais LK, Bollenrucher N, Chang E, Ali LR, Lenehan PJ, Dolgalev I, Werba G, Lima C, Keheler CE, Sullivan KM, Dougan M, Hajdu C, Dajee M, Pelletier MR, Nazeer S, Squires M, Bar-Sagi D, Wolpin BM, Nowak JA, Simeone DM, Dougan SK. PMID: 38990554; PMCID: PMC11369625.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCellsCTClinical Trials
    9. UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A. 2024 Aug 13; 121(33):e2401996121. Su W, Kochen Rossi J, Nuevo-Tapioles C, Chen T, Kawaler E, Branco C, Wong KK, Simeone DM, Gardner LB, Philips MR. PMID: 40591563; PMCID: PMC11331118.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Detecting HLA loss of heterozygosity within a standard diagnostic sequencing workflow for prognostic and therapeutic opportunities. NPJ Precis Oncol. 2024 Aug 05; 8(1):174. Lozac'hmeur A, Danek T, Yang Q, Rosasco MG, Welch JS, Go WY, Ng EW, Mardiros A, Maloney DG, Garon EB, Kirtane K, Simeone DM, Molina JR, Salahudeen AA, Stein MM, Hecht JR. PMID: 39103508; PMCID: PMC11300791.
      View in: PubMed   Mentions: 6  
    11. Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer. Nat Med. 2024 Aug; 30(8):2170-2180. Bojmar L, Zambirinis CP, Hernandez JM, Chakraborty J, Shaashua L, Kim J, Johnson KE, Hanna S, Askan G, Burman J, Ravichandran H, Zheng J, Jolissaint JS, Srouji R, Song Y, Choubey A, Kim HS, Cioffi M, van Beek E, Sigel C, Jessurun J, Velasco Riestra P, Blomstrand H, Jönsson C, Jönsson A, Lauritzen P, Buehring W, Ararso Y, Hernandez D, Vinagolu-Baur JP, Friedman M, Glidden C, Firmenich L, Lieberman G, Mejia DL, Nasar N, Mutvei AP, Paul DM, Bram Y, Costa-Silva B, Basturk O, Boudreau N, Zhang H, Matei IR, Hoshino A, Kelsen D, Sagi I, Scherz A, Scherz-Shouval R, Yarden Y, Oren M, Egeblad M, Lewis JS, Keshari K, Grandgenett PM, Hollingsworth MA, Rajasekhar VK, Healey JH, Björnsson B, Simeone DM, Tuveson DA, Iacobuzio-Donahue CA, Bromberg J, Vincent CT, O'Reilly EM, DeMatteo RP, Balachandran VP, D'Angelica MI, Kingham TP, Allen PJ, Simpson AL, Elemento O, Sandström P, Schwartz RE, Jarnagin WR, Lyden D. PMID: 38942992; PMCID: PMC11416063.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    12. The role of family history in predicting germline pathogenic variant carriers who develop pancreatic cancer: Results of a multicenter collaboration. Cancer. 2024 Oct 01; 130(19):3297-3304. Karloski E, Dudley B, Diergaarde B, Blanco A, Everett JN, Levinson E, Rangarajan T, Stanich PP, Childers K, Brown S, Drogan C, Cavestro GM, Gordon K, Singh A, Simeone DM, Reich H, Kastrinos F, Zakalik D, Hampel H, Pearlman R, Gordon OK, Kupfer SS, Puzzono M, Zuppardo RA, Brand RE. PMID: 38809542; PMCID: PMC11371512.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. The Pancreatic Cancer Early Detection (PRECEDE) Study is a Global Effort to Drive Early Detection: Baseline Imaging Findings in High-Risk Individuals. J Natl Compr Canc Netw. 2024 04; 22(3):158-166. Zogopoulos G, Haimi I, Sanoba SA, Everett JN, Wang Y, Katona BW, Farrell JJ, Grossberg AJ, Paiella S, Klute KA, Bi Y, Wallace MB, Kwon RS, Stoffel EM, Wadlow RC, Sussman DA, Merchant NB, Permuth JB, Golan T, Raitses-Gurevich M, Lowy AM, Liau J, Jeter JM, Lindberg JM, Chung DC, Earl J, Brentnall TA, Schrader KA, Kaul V, Huang C, Chandarana H, Smerdon C, Graff JJ, Kastrinos F, Kupfer SS, Lucas AL, Sears RC, Brand RE, Parmigiani G, Simeone DM, PRECEDE Consortium. PMID: 38626807; PMCID: PMC12344727.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Somatic Mutational Analysis in Endoscopic Ultrasound-Guided Biopsy of Pancreatic Adenocarcinoma: Assessing Yield and Impact. Am J Gastroenterol. 2024 Aug 01; 119(8):1636-1639. Dong S, Agarunov E, Fasullo M, Kim KY, Khanna L, Haber G, Janec E, Simeone D, Oberstein P, Gonda T. PMID: 38546128.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Gallium-68-labeled fibroblast activation protein inhibitor-46 PET in patients with resectable or borderline resectable pancreatic ductal adenocarcinoma: A phase 2, multicenter, single arm, open label non-randomized study protocol. PLoS One. 2023; 18(11):e0294564. Karbhari A, Mosessian S, Trivedi KH, Valla F, Jacobson M, Truty MJ, Patnam NG, Simeone DM, Zan E, Brennan T, Chen H, Kuo PH, Herrmann K, Goenka AH. PMID: 38011131; PMCID: PMC10681241.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    16. Progression of Site-specific Recurrence of Pancreatic Cancer and Implications for Treatment. Ann Surg. 2024 Aug 01; 280(2):317-324. Rompen IF, Levine J, Habib JR, Sereni E, Mughal N, Hewitt DB, Sacks GD, Welling TH, Simeone DM, Kaplan B, Berman RS, Cohen SM, Wolfgang CL, Javed AA. PMID: 37870253; PMCID: PMC11259998.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Targeting pancreatic cancer metabolic dependencies through glutamine antagonism. Nat Cancer. 2024 01; 5(1):85-99. Encarnación-Rosado J, Sohn ASW, Biancur DE, Lin EY, Osorio-Vasquez V, Rodrick T, González-Baerga D, Zhao E, Yokoyama Y, Simeone DM, Jones DR, Parker SJ, Wild R, Kimmelman AC. PMID: 37814010; PMCID: PMC10824664.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    18. A Blueprint for a Comprehensive, Multidisciplinary Pancreatic Cancer Screening Program. Am J Gastroenterol. 2024 03 01; 119(3):404-408. Fasullo M, Simeone D, Everett J, Agarunov E, Khanna L, Gonda T. PMID: 37782292.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    19. Surveillance of Individuals at High Risk of Developing Pancreatic Cancer: A Prevalence Meta-analysis to Estimate the Rate of Low-yield Surgery. Ann Surg. 2024 01 01; 279(1):37-44. Paiella S, Secchettin E, Lionetto G, Archibugi L, Azzolina D, Casciani F, Simeone DM, Overbeek KA, Goggins M, Farrell J, Ponz de Leon Pisani R, Tridenti M, Corciulo MA, Malleo G, Arcidiacono PG, Falconi M, Gregori D, Bassi C, Salvia R, Capurso G. PMID: 37681303.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Author Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. Nat Commun. 2023 Jul 03; 14(1):3912. Werba G, Weissinger D, Kawaler EA, Zhao E, Kalfakakou D, Dhara S, Wang L, Lim HB, Oh G, Jing X, Beri N, Khanna L, Gonda T, Oberstein P, Hajdu C, Loomis C, Heguy A, Sherman MH, Lund AW, Welling TH, Dolgalev I, Tsirigos A, Simeone DM. PMID: 37400453; PMCID: PMC10317973.
      View in: PubMed   Mentions: 2     Fields:    
    21. Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance. Cancer Prev Res (Phila). 2023 06 01; 16(6):343-352. Katona BW, Klute K, Brand RE, Everett JN, Farrell JJ, Hawthorne K, Kaul V, Kupfer SS, Paiella S, Simeone DM, Sussman DA, Zogopoulos G, Lucas AL, Kastrinos F, PRECEDE Consortium. PMID: 37259800; PMCID: PMC12380199.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    22. POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling. J Clin Invest. 2023 06 01; 133(11). Oh G, Wang A, Wang L, Li J, Werba G, Weissinger D, Zhao E, Dhara S, Hernandez RE, Ackermann A, Porcella S, Kalfakakou D, Dolgalev I, Kawaler E, Golan T, Welling TH, Sfeir A, Simeone DM. PMID: 36976649; PMCID: PMC10232002.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    23. Are All Cysts Created Equal?: Pancreatic Cystic Neoplasms in Patients with Familial or Genetic Risk Factors for Pancreatic Cancer. Gastrointest Endosc Clin N Am. 2023 07; 33(3):547-557. Haimi I, Sanoba S, Everett J, Simeone DM. PMID: 37245935.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Corrigendum: Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies. Front Immunol. 2023; 14:1177713. Wan S, Zhao E, Freeman D, Weissinger D, Krantz BA, Werba G, Khanna LG, Siolas D, Oberstein PE, Chattopadhyay PK, Simeone DM, Welling TH. PMID: 37033968; PMCID: PMC10078804.
      View in: PubMed   Mentions:    Fields:    
    25. A systematic review and meta-analysis of germline BRCA mutations in pancreatic cancer patients identifies global and racial disparities in access to genetic testing. ESMO Open. 2023 04; 8(2):100881. Paiella S, Azzolina D, Gregori D, Malleo G, Golan T, Simeone DM, Davis MB, Vacca PG, Crovetto A, Bassi C, Salvia R, Biankin AV, Casolino R. PMID: 36822114; PMCID: PMC10163165.
      View in: PubMed   Mentions: 8  Translation:Humans
    26. Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. Nat Commun. 2023 02 13; 14(1):797. Werba G, Weissinger D, Kawaler EA, Zhao E, Kalfakakou D, Dhara S, Wang L, Lim HB, Oh G, Jing X, Beri N, Khanna L, Gonda T, Oberstein P, Hajdu C, Loomis C, Heguy A, Sherman MH, Lund AW, Welling TH, Dolgalev I, Tsirigos A, Simeone DM. PMID: 36781852; PMCID: PMC9925748.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    27. Advancing Clinical Trial Innovation in Pancreatic Cancer: A Conversation Between Diane Simeone, Ken Herrmann, and Johannes Czernin. J Nucl Med. 2023 02; 64(2):185-187. Simeone DM, Herrmann K, Czernin J. PMID: 36725247.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies. Front Immunol. 2023; 14:1067352. Wan S, Zhao E, Weissinger D, Krantz BA, Werba G, Freeman D, Khanna LG, Siolas D, Oberstein PE, Chattopadhyay PK, Simeone DM, Welling TH. PMID: 36798126; PMCID: PMC9927010.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells. Cancers (Basel). 2022 Aug 27; 14(17). Xu J, Yang R, Li J, Wang L, Cohen M, Simeone DM, Costa M, Wu XR. PMID: 36077697; PMCID: PMC9454896.
      View in: PubMed   Mentions: 4  
    30. Functional and biological heterogeneity of KRASQ61 mutations. Sci Signal. 2022 08 09; 15(746):eabn2694. Huynh MV, Hobbs GA, Schaefer A, Pierobon M, Carey LM, Diehl JN, DeLiberty JM, Thurman RD, Cooke AR, Goodwin CM, Cook JH, Lin L, Waters AM, Rashid NU, Petricoin EF, Campbell SL, Haigis KM, Simeone DM, Lyssiotis CA, Cox AD, Der CJ. PMID: 35944066; PMCID: PMC9534304.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    31. Proteomes of Extracellular Vesicles From Pancreatic Cancer Cells and Cancer-Associated Fibroblasts. Pancreas. 2022 08 01; 51(7):790-799. Pan S, Lai LA, Simeone DM, Dawson DW, Yan Y, Crnogorac-Jurcevic T, Chen R, Brentnall TA. PMID: 36395405; PMCID: PMC9678144.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting. Cancer Med. 2023 02; 12(3):2345-2355. Everett JN, Sanoba SA, Jing X, Stender C, Schmitter M, Baptiste A, Chun J, Kawaler EA, Khanna LG, Gross SA, Gonda TA, Beri N, Oberstein PE, Simeone DM. PMID: 35906821; PMCID: PMC9939217.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    33. Standardization of MRI Screening and Reporting in Individuals With Elevated Risk of Pancreatic Ductal Adenocarcinoma: Consensus Statement of the PRECEDE Consortium. AJR Am J Roentgenol. 2022 12; 219(6):903-914. Huang C, Simeone DM, Luk L, Hecht EM, Khatri G, Kambadakone A, Chandarana H, Ream JM, Everett JN, Guimaraes A, Liau J, Dasyam AK, Harmath C, Megibow AJ, PRECEDE Consortium. PMID: 35856454.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    34. Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment. Gastroenterology. 2022 08; 163(2):386-402.e1. Wood LD, Canto MI, Jaffee EM, Simeone DM. PMID: 35398344; PMCID: PMC9516440.
      View in: PubMed   Mentions: 350     Fields:    Translation:Humans
    35. Standardization of EUS imaging and reporting in high-risk individuals of pancreatic adenocarcinoma: consensus statement of the Pancreatic Cancer Early Detection Consortium. Gastrointest Endosc. 2022 Apr; 95(4):723-732.e7. Gonda TA, Farrell J, Wallace M, Khanna L, Janec E, Kwon R, Saunders M, Siddiqui UD, Brand R, Simeone DM, PRECEDE Consortium. PMID: 34736932.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    36. Cyst fluid metabolites distinguish malignant from benign pancreatic cysts. Neoplasia. 2021 11; 23(11):1078-1088. Shi J, Yi Z, Jin L, Zhao L, Raskind A, Yeomans L, Nwosu ZC, Simeone DM, Lyssiotis CA, Stringer KA, Kwon RS. PMID: 34583246; PMCID: PMC8479274.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    37. Recommendations for a More Organized and Effective Approach to the Early Detection of Pancreatic Cancer From the PRECEDE (Pancreatic Cancer Early Detection) Consortium. Gastroenterology. 2021 12; 161(6):1751-1757. Gonda TA, Everett JN, Wallace M, Simeone DM, PRECEDE Consortium. PMID: 34454916.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    38. Proteome heterogeneity and malignancy detection in pancreatic cyst fluids. Clin Transl Med. 2021 08; 11(8):e506. Pan S, Brand RE, Lai LA, Dawson DW, Donahue TR, Kim S, Khalaf NI, Othman MO, Fisher WE, Bronner MP, Simeone DM, Brentnall TA, Chen R. PMID: 34459141; PMCID: PMC8382978.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    39. A pan-cancer organoid platform for precision medicine. Cell Rep. 2021 07 27; 36(4):109429. Larsen BM, Kannan M, Langer LF, Leibowitz BD, Bentaieb A, Cancino A, Dolgalev I, Drummond BE, Dry JR, Ho CS, Khullar G, Krantz BA, Mapes B, McKinnon KE, Metti J, Perera JF, Rand TA, Sanchez-Freire V, Shaxted JM, Stein MM, Streit MA, Tan YC, Zhang Y, Zhao E, Venkataraman J, Stumpe MC, Borgia JA, Masood A, Catenacci DVT, Mathews JV, Gursel DB, Wei JJ, Welling TH, Simeone DM, White KP, Khan AA, Igartua C, Salahudeen AA. PMID: 34320344.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    40. Impact of changing guidelines on genetic testing and surveillance recommendations in a contemporary cohort of breast cancer survivors with family history of pancreatic cancer. Sci Rep. 2021 06 14; 11(1):12491. Wang A, Everett JN, Chun J, Cen C, Simeone DM, Schnabel F. PMID: 34127761; PMCID: PMC8203798.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. The biological underpinnings of therapeutic resistance in pancreatic cancer. Genes Dev. 2021 07 01; 35(13-14):940-962. Beatty GL, Werba G, Lyssiotis CA, Simeone DM. PMID: 34117095; PMCID: PMC8247606.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    42. Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis. Nat Commun. 2021 04 06; 12(1):2047. Xia Y, Liu Y, Yang C, Simeone DM, Sun TT, DeGraff DJ, Tang MS, Zhang Y, Wu XR. PMID: 33824349; PMCID: PMC8024281.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    43. A novel target for combination immunotherapy in pancreatic cancer: IL-1β mediates immunosuppression in the tumour microenvironment. Br J Cancer. 2021 05; 124(11):1754-1756. Winograd R, Simeone DM, Bar-Sagi D. PMID: 33758330; PMCID: PMC8144204.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    44. Cancer surveillance awareness and practice among families at increased risk for pancreatic adenocarcinoma. Cancer. 2021 07 01; 127(13):2271-2278. Everett JN, Burgos G, Chun J, Baptiste A, Khanna LG, Oberstein PE, Simeone DM. PMID: 33721345.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    45. ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. Genes Dev. 2021 02 01; 35(3-4):218-233. Purohit V, Wang L, Yang H, Li J, Ney GM, Gumkowski ER, Vaidya AJ, Wang A, Bhardwaj A, Zhao E, Dolgalev I, Zamperone A, Abel EV, Magliano MPD, Crawford HC, Diolaiti D, Papagiannakopoulos TY, Lyssiotis CA, Simeone DM. PMID: 33446568; PMCID: PMC7849366.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    46. Author Correction: Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas. Nat Biotechnol. 2020 Dec; 38(12):1476. Moncada R, Barkley D, Wagner F, Chiodin M, Devlin JC, Baron M, Hajdu CH, Simeone DM, Yanai I. PMID: 33230294.
      View in: PubMed   Mentions: 9     Fields:    
    47. Needle-compatible miniaturized optoelectronic sensor for pancreatic cancer detection. Sci Adv. 2020 11; 6(47). Lee SY, Pakela JM, Na K, Shi J, McKenna BJ, Simeone DM, Yoon E, Scheiman JM, Mycek MA. PMID: 33219025; PMCID: PMC7679167.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    48. Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer. Gastroenterology. 2021 01; 160(1):362-377.e13. Dreyer SB, Upstill-Goddard R, Paulus-Hock V, Paris C, Lampraki EM, Dray E, Serrels B, Caligiuri G, Rebus S, Plenker D, Galluzzo Z, Brunton H, Cunningham R, Tesson M, Nourse C, Bailey UM, Jones M, Moran-Jones K, Wright DW, Duthie F, Oien K, Evers L, McKay CJ, McGregor GA, Gulati A, Brough R, Bajrami I, Pettitt S, Dziubinski ML, Candido J, Balkwill F, Barry ST, Grützmann R, Rahib L, Glasgow Precision Oncology Laboratory, , Australian Pancreatic Cancer Genome Initiative, Johns A, Pajic M, Froeling FEM, Beer P, Musgrove EA, Petersen GM, Ashworth A, Frame MC, Crawford HC, Simeone DM, Lord C, Mukhopadhyay D, Pilarsky C, Tuveson DA, Cooke SL, Jamieson NB, Morton JP, Sansom OJ, Bailey PJ, Biankin AV, Chang DK. PMID: 33039466; PMCID: PMC8167930.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
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    50. Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer. Gut. 2021 04; 70(4):743-760. Gout J, Perkhofer L, Morawe M, Arnold F, Ihle M, Biber S, Lange S, Roger E, Kraus JM, Stifter K, Hahn SA, Zamperone A, Engleitner T, Müller M, Walter K, Rodriguez-Aznar E, Sainz B, Hermann PC, Hessmann E, Müller S, Azoitei N, Lechel A, Liebau S, Wagner M, Simeone DM, Kestler HA, Seufferlein T, Wiesmüller L, Rad R, Frappart PO, Kleger A. PMID: 32873698; PMCID: PMC7948173.
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    53. HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer. Cell Rep. 2020 05 12; 31(6):107625. Brunton H, Caligiuri G, Cunningham R, Upstill-Goddard R, Bailey UM, Garner IM, Nourse C, Dreyer S, Jones M, Moran-Jones K, Wright DW, Paulus-Hock V, Nixon C, Thomson G, Jamieson NB, McGregor GA, Evers L, McKay CJ, Gulati A, Brough R, Bajrami I, Pettitt SJ, Dziubinski ML, Barry ST, Grützmann R, Brown R, Curry E, Glasgow Precision Oncology Laboratory, Australian Pancreatic Cancer Genome Initiative, Pajic M, Musgrove EA, Petersen GM, Shanks E, Ashworth A, Crawford HC, Simeone DM, Froeling FEM, Lord CJ, Mukhopadhyay D, Pilarsky C, Grimmond SE, Morton JP, Sansom OJ, Chang DK, Bailey PJ, Biankin AV. PMID: 32402285; PMCID: PMC9511995.
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    54. Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy. Mol Cancer Ther. 2020 06; 19(6):1308-1319. Anbil S, Pigula M, Huang HC, Mallidi S, Broekgaarden M, Baglo Y, De Silva P, Simeone DM, Mino-Kenudson M, Maytin EV, Rizvi I, Hasan T. PMID: 32220968; PMCID: PMC7272264.
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    57. Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium. Gut. 2020 01; 69(1):7-17. Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M, International Cancer of the Pancreas Screening (CAPS) consortium. PMID: 31672839; PMCID: PMC7295005.
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    58. Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates: Towards Conquering Desmoplasia? Nano Lett. 2019 11 13; 19(11):7573-7587. Obaid G, Bano S, Mallidi S, Broekgaarden M, Kuriakose J, Silber Z, Bulin AL, Wang Y, Mai Z, Jin W, Simeone D, Hasan T. PMID: 31518145; PMCID: PMC6934365.
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    59. A Phase I/II Open-Label Multicenter Single-Arm Study of FABLOx (Metronomic 5-Fluorouracil Plus nab-Paclitaxel, Bevacizumab, Leucovorin, and Oxaliplatin) in Patients with Metastatic Pancreatic Cancer. J Pancreat Cancer. 2019; 5(1):35-42. Sahai V, Saif MW, Kalyan A, Philip PA, Rocha-Lima CM, Ocean A, Ondovik MS, Simeone DM, Banerjee S, Bhore R, Louis CU, Picozzi V. PMID: 31559379; PMCID: PMC6761587.
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    60. Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing. Am J Gastroenterol. 2019 09; 114(9):1539-1549. Majumder S, Taylor WR, Yab TC, Berger CK, Dukek BA, Cao X, Foote PH, Wu CW, Mahoney DW, Aslanian HR, Fernández-Del Castillo C, Doyle LA, Farrell JJ, Fisher WE, Lee LS, Lee YN, Park W, Rodrigues C, Gould Rothberg BE, Salem RR, Simeone DM, Urs S, Van Buren G, Smyrk TC, Allawi HT, Lidgard GP, Raimondo M, Chari ST, Kendrick ML, Kisiel JB, Topazian MD, Ahlquist DA. PMID: 31306149; PMCID: PMC7294458.
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    61. Metabolic Regulation of Redox Balance in Cancer. Cancers (Basel). 2019 Jul 08; 11(7). Purohit V, Simeone DM, Lyssiotis CA. PMID: 31288436; PMCID: PMC6678865.
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    63. ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis. Genes Dev. 2019 06 01; 33(11-12):641-655. Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM. PMID: 31048544; PMCID: PMC6546061.
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    64. Low dose photodynamic therapy harmonizes with radiation therapy to induce beneficial effects on pancreatic heterocellular spheroids. Oncotarget. 2019 Apr 05; 10(27):2625-2643. Bulin AL, Broekgaarden M, Simeone D, Hasan T. PMID: 31080554; PMCID: PMC6499000.
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    65. ATDC mediates a TP63-regulated basal cancer invasive program. Oncogene. 2019 05; 38(18):3340-3354. Palmbos PL, Wang Y, Bankhead Iii A, Kelleher AJ, Wang L, Yang H, Ahmet ML, Gumkowski ER, Welling SD, Magnuson B, Leflein J, Lorenzatti Hiles G, Abel EV, Dziubinski ML, Urs S, Day ML, Ljungman ME, Simeone DM. PMID: 30643195; PMCID: PMC6499660.
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    66. Pancreatic Microtumors: A Novel 3D Ex Vivo Testing Platform. Methods Mol Biol. 2019; 1882:73-80. Goodwin ML, Urs SK, Simeone DM. PMID: 30378045.
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    67. Pilot Study of Personalized Video Visit Summaries for Patients With Cancer. JCO Clin Cancer Inform. 2018 12; 2:1-8. Krauss JC, Sahai V, Kirch M, Simeone DM, An L. PMID: 30652554; PMCID: PMC9797237.
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    68. Evaluating Susceptibility to Pancreatic Cancer: ASCO Provisional Clinical Opinion. J Clin Oncol. 2019 01 10; 37(2):153-164. Stoffel EM, McKernin SE, Brand R, Canto M, Goggins M, Moravek C, Nagarajan A, Petersen GM, Simeone DM, Yurgelun M, Khorana AA. PMID: 30457921.
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    69. Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers. Mol Cancer Ther. 2018 12; 17(12):2495-2506. Maust JD, Frankowski-McGregor CL, Bankhead A, Simeone DM, Sebolt-Leopold JS. PMID: 30254182; PMCID: PMC6279520.
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    72. HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties. Elife. 2018 08 03; 7. Abel EV, Goto M, Magnuson B, Abraham S, Ramanathan N, Hotaling E, Alaniz AA, Kumar-Sinha C, Dziubinski ML, Urs S, Wang L, Shi J, Waghray M, Ljungman M, Crawford HC, Simeone DM. PMID: 30074477; PMCID: PMC6122955.
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    74. HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas. Gastroenterology. 2018 05; 154(6):1630-1634.e3. Park MJ, Iyer S, Xue X, Bragazzi Cunha J, Gu S, Moons D, Pipe SW, Williams JA, Simeone DM, Shah YM, Omary MB. PMID: 29409830; PMCID: PMC5927829.
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    76. Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth. Neoplasia. 2018 02; 20(2):152-164. Pal A, Dziubinski M, Di Magliano MP, Simeone DM, Owens S, Thomas D, Peterson L, Potu H, Talpaz M, Donato NJ. PMID: 29248719; PMCID: PMC5735260.
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    77. Definitive Chemoradiation With Full-dose Gemcitabine for Unresectable Pancreatic Cancer: Efficacy of Involved-Field Radiotherapy. Am J Clin Oncol. 2017 Oct; 40(5):517-522. Zhou J, Fang CX, Shen J, Schipper MJ, Zalupski MM, Minter RM, Simeone DM, Hart D, Eagle T, Kimmel GW, Vainshtein J, Lawrence TS, Feng M. PMID: 26165418.
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    78. High-Throughput Microfluidic Labyrinth for the Label-free Isolation of Circulating Tumor Cells. Cell Syst. 2017 09 27; 5(3):295-304.e4. Lin E, Rivera-Báez L, Fouladdel S, Yoon HJ, Guthrie S, Wieger J, Deol Y, Keller E, Sahai V, Simeone DM, Burness ML, Azizi E, Wicha MS, Nagrath S. PMID: 28941584.
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    82. A Gastric Glycoform of MUC5AC Is a Biomarker of Mucinous Cysts of the Pancreas. PLoS One. 2016; 11(12):e0167070. Sinha J, Cao Z, Dai J, Tang H, Partyka K, Hostetter G, Simeone DM, Feng Z, Allen PJ, Brand RE, Haab BB. PMID: 27992432; PMCID: PMC5167232.
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    85. A phase I trial of cabozantinib and gemcitabine in advanced pancreatic cancer. Invest New Drugs. 2016 12; 34(6):733-739. Zhen DB, Griffith KA, Ruch JM, Camphausen K, Savage JE, Kim EJ, Sahai V, Simeone DM, Zalupski MM. PMID: 27439894; PMCID: PMC7458140.
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    87. Opportunities and Challenges for Pancreatic Circulating Tumor Cells. Gastroenterology. 2016 09; 151(3):412-26. Nagrath S, Jack RM, Sahai V, Simeone DM. PMID: 27339829.
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    88. GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer. Cancer Discov. 2016 08; 6(8):886-99. Waghray M, Yalamanchili M, Dziubinski M, Zeinali M, Erkkinen M, Yang H, Schradle KA, Urs S, Pasca Di Magliano M, Welling TH, Palmbos PL, Abel EV, Sahai V, Nagrath S, Wang L, Simeone DM. PMID: 27184426; PMCID: PMC5549011.
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    89. Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells. Adv Mater. 2016 Jun; 28(24):4891-7. Yoon HJ, Shanker A, Wang Y, Kozminsky M, Jin Q, Palanisamy N, Burness ML, Azizi E, Simeone DM, Wicha MS, Kim J, Nagrath S. PMID: 27115557; PMCID: PMC5680542.
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    90. Ultra-Specific Isolation of Circulating Tumor Cells Enables Rare-Cell RNA Profiling. Adv Sci (Weinh). 2016 Sep; 3(9):1600063. Jack RM, Grafton MM, Rodrigues D, Giraldez MD, Griffith C, Cieslak R, Zeinali M, Kumar Sinha C, Azizi E, Wicha M, Tewari M, Simeone DM, Nagrath S. PMID: 27711257; PMCID: PMC5039969.
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    91. Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis. Gut. 2017 06; 66(6):1001-1011. Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC. PMID: 26933171; PMCID: PMC5009003.
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    92. Localized Pancreatic Cancer: Multidisciplinary Management. Am Soc Clin Oncol Educ Book. 2016; 35:e217-26. Coveler AL, Herman JM, Simeone DM, Chiorean EG. PMID: 27249726.
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    93. ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms. Cancer Res. 2015 Dec 01; 75(23):5155-66. Palmbos PL, Wang L, Yang H, Wang Y, Leflein J, Ahmet ML, Wilkinson JE, Kumar-Sinha C, Ney GM, Tomlins SA, Daignault S, Kunju LP, Wu XR, Lotan Y, Liebert M, Ljungman ME, Simeone DM. PMID: 26471361; PMCID: PMC4668224.
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    95. Early detection of sporadic pancreatic cancer: summative review. Pancreas. 2015 Jul; 44(5):693-712. Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter DF, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D. PMID: 25931254; PMCID: PMC4467589.
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    96. Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism. Carcinogenesis. 2015 Jul; 36(7):730-8. Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M. PMID: 25939753; PMCID: PMC4566095.
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    97. Large-scale identification of core-fucosylated glycopeptide sites in pancreatic cancer serum using mass spectrometry. J Proteome Res. 2015 Apr 03; 14(4):1968-78. Tan Z, Yin H, Nie S, Lin Z, Zhu J, Ruffin MT, Anderson MA, Simeone DM, Lubman DM. PMID: 25732060; PMCID: PMC4410993.
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    98. ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis. Genes Dev. 2015 Jan 15; 29(2):171-83. Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM. PMID: 25593307; PMCID: PMC4298136.
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    99. CD44 regulates pancreatic cancer invasion through MT1-MMP. Mol Cancer Res. 2015 Jan; 13(1):9-15. Jiang W, Zhang Y, Kane KT, Collins MA, Simeone DM, di Magliano MP, Nguyen KT. PMID: 25566991; PMCID: PMC4362532.
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    100. Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model. Oncotarget. 2014 Dec 15; 5(23):12383-97. Zhang Z, Shiratsuchi H, Lin J, Chen G, Reddy RM, Azizi E, Fouladdel S, Chang AC, Lin L, Jiang H, Waghray M, Luker G, Simeone DM, Wicha MS, Beer DG, Ramnath N, Nagrath S. PMID: 25474037; PMCID: PMC4323004.
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    101. Tumor-associated macrophages are a useful biomarker to predict recurrence after surgical resection of nonfunctional pancreatic neuroendocrine tumors. Ann Surg. 2014 Dec; 260(6):1088-94. Wei IH, Harmon CM, Arcerito M, Cheng DF, Minter RM, Simeone DM. PMID: 25389924; PMCID: PMC4312612.
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    102. Quantitative analysis of single amino acid variant peptides associated with pancreatic cancer in serum by an isobaric labeling quantitative method. J Proteome Res. 2014 Dec 05; 13(12):6058-66. Nie S, Yin H, Tan Z, Anderson MA, Ruffin MT, Simeone DM, Lubman DM. PMID: 25393578; PMCID: PMC4261938.
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    103. Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma. Lab Invest. 2015 Jan; 95(1):43-55. Chen R, Dawson DW, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, May DH, Crispin DA, Lai LA, Lay AR, Waghray M, Wang S, McIntosh MW, Simeone DM, Maitra A, Brentnall TA. PMID: 25347153; PMCID: PMC4281293.
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    104. A pilot study of diffusion-weighted MRI in patients undergoing neoadjuvant chemoradiation for pancreatic cancer. Transl Oncol. 2014 Oct; 7(5):644-9. Cuneo KC, Chenevert TL, Ben-Josef E, Feng MU, Greenson JK, Hussain HK, Simeone DM, Schipper MJ, Anderson MA, Zalupski MM, Al-Hawary M, Galban CJ, Rehemtulla A, Feng FY, Lawrence TS, Ross BD. PMID: 25389460; PMCID: PMC4225651.
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    105. Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma. Clin Cancer Res. 2014 Dec 01; 20(23):5937-5945. Kim EJ, Sahai V, Abel EV, Griffith KA, Greenson JK, Takebe N, Khan GN, Blau JL, Craig R, Balis UG, Zalupski MM, Simeone DM. PMID: 25278454; PMCID: PMC4254161.
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    106. Recent advances in pancreatic surgery. Curr Opin Gastroenterol. 2014 Sep; 30(5):518-23. Bednar F, Simeone DM. PMID: 25010685.
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    107. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology. 2014 Dec; 147(6):1393-404. Wan S, Zhao E, Kryczek I, Vatan L, Sadovskaya A, Ludema G, Simeone DM, Zou W, Welling TH. PMID: 25181692; PMCID: PMC4253315.
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    108. A radial flow microfluidic device for ultra-high-throughput affinity-based isolation of circulating tumor cells. Small. 2014 Dec 10; 10(23):4895-904. Murlidhar V, Zeinali M, Grabauskiene S, Ghannad-Rezaie M, Wicha MS, Simeone DM, Ramnath N, Reddy RM, Nagrath S. PMID: 25074448; PMCID: PMC4455044.
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    109. Clinical evaluation, imaging studies, indications for cytologic study and preprocedural requirements for duct brushing studies and pancreatic fine-needle aspiration: The Papanicolaou Society of Cytopathology Guidelines. Cytojournal. 2014; 11(Suppl 1):1. Adler D, Schmidt CM, Al-Haddad M, Barthel JS, Ljung BM, Merchant NB, Romagnuolo J, Shaaban AM, Simeone D, Pitman MB, Layfield LJ. PMID: 25191515; PMCID: PMC4153337.
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    110. Post-brushing and fine-needle aspiration biopsy follow-up and treatment options for patients with pancreatobiliary lesions: The Papanicolaou Society of Cytopathology Guidelines. Cytojournal. 2014; 11(Suppl 1):5. Kurtycz DF, Field A, Tabatabai L, Michaels C, Young N, Schmidt CM, Farrell J, Gopal D, Simeone D, Merchant NB, Pitman MB. PMID: 25191519; PMCID: PMC4153339.
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    111. Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes. Lab Chip. 2014 Jun 07; 14(11):1891-900. Kanwar SS, Dunlay CJ, Simeone DM, Nagrath S. PMID: 24722878; PMCID: PMC4134440.
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    112. Postbrushing and fine-needle aspiration biopsy follow-up and treatment options for patients with pancreatobiliary lesions: the Papanicolaou Society of Cytopathology guidelines. Diagn Cytopathol. 2014 Apr; 42(4):363-71. Kurtycz D, Tabatabai ZL, Michaels C, Young N, Schmidt CM, Farrell J, Gopal D, Simeone D, Merchant NB, Field A, Pitman MB, Papanicolaou Society of Cytopathology. PMID: 24639399.
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    113. The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer. PLoS One. 2014; 9(3):e91983. Abel EV, Kim EJ, Wu J, Hynes M, Bednar F, Proctor E, Wang L, Dziubinski ML, Simeone DM. PMID: 24647545; PMCID: PMC3960140.
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    114. Glycoprotein biomarker panel for pancreatic cancer discovered by quantitative proteomics analysis. J Proteome Res. 2014 Apr 04; 13(4):1873-84. Nie S, Lo A, Wu J, Zhu J, Tan Z, Simeone DM, Anderson MA, Shedden KA, Ruffin MT, Lubman DM. PMID: 24571389; PMCID: PMC3993962.
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    115. Clinical evaluation, imaging studies, indications for cytologic study, and preprocedural requirements for duct brushing studies and pancreatic FNA: the Papanicolaou Society of Cytopathology recommendations for pancreatic and biliary cytology. Diagn Cytopathol. 2014 Apr; 42(4):325-32. Adler D, Max Schmidt C, Al-Haddad M, Barthel JS, Ljung BM, Merchant NB, Romagnuolo J, Shaaban AM, Simeone D, Bishop Pitman M, Field A, Layfield LJ, Papanicolaou Society of Cytopathology. PMID: 24554480.
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    116. ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. Cancer Res. 2014 Mar 15; 74(6):1778-88. Wang L, Yang H, Palmbos PL, Ney G, Detzler TA, Coleman D, Leflein J, Davis M, Zhang M, Tang W, Hicks JK, Helchowski CM, Prasad J, Lawrence TS, Xu L, Yu X, Canman CE, Ljungman M, Simeone DM. PMID: 24469230; PMCID: PMC3961828.
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    117. Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice. Gastroenterology. 2014 Apr; 146(4):1108-18. Li L, Hao X, Qin J, Tang W, He F, Smith A, Zhang M, Simeone DM, Qiao XT, Chen ZN, Lawrence TS, Xu L. PMID: 24397969; PMCID: PMC3982149.
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    118. Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the society of abdominal radiology and the american pancreatic association. Gastroenterology. 2014 Jan; 146(1):291-304.e1. Al-Hawary MM, Francis IR, Chari ST, Fishman EK, Hough DM, Lu DS, Macari M, Megibow AJ, Miller FH, Mortele KJ, Merchant NB, Minter RM, Tamm EP, Sahani DV, Simeone DM. PMID: 24355035.
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    119. Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the Society of Abdominal Radiology and the American Pancreatic Association. Radiology. 2014 Jan; 270(1):248-60. Al-Hawary MM, Francis IR, Chari ST, Fishman EK, Hough DM, Lu DS, Macari M, Megibow AJ, Miller FH, Mortele KJ, Merchant NB, Minter RM, Tamm EP, Sahani DV, Simeone DM. PMID: 24354378.
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    120. Label-free relative quantification of alpha-2-macroglobulin site-specific core-fucosylation in pancreatic cancer by LC-MS/MS. Electrophoresis. 2014 Aug; 35(15):2108-15. Lin Z, Yin H, Lo A, Ruffin MT, Anderson MA, Simeone DM, Lubman DM. PMID: 24285556; PMCID: PMC4035462.
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    121. Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling. Mol Cancer Ther. 2014 Feb; 13(2):386-98. Michaud NR, Wang Y, McEachern KA, Jordan JJ, Mazzola AM, Hernandez A, Jalla S, Chesebrough JW, Hynes MJ, Belmonte MA, Wang L, Kang JS, Jovanovic J, Laing N, Jenkins DW, Hurt E, Liang M, Frantz C, Hollingsworth RE, Simeone DM, Blakey DC, Bedian V. PMID: 24344235.
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    122. In vivo optical spectroscopy for improved detection of pancreatic adenocarcinoma: a feasibility study. Biomed Opt Express. 2013 Dec 02; 5(1):9-15. Lloyd WR, Wilson RH, Lee SY, Chandra M, McKenna B, Simeone D, Scheiman J, Mycek MA. PMID: 24466472; PMCID: PMC3891348.
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    123. Characterizing human pancreatic cancer precursor using quantitative tissue optical spectroscopy. Biomed Opt Express. 2013; 4(12):2828-34. Lee SY, Lloyd WR, Chandra M, Wilson RH, McKenna B, Simeone D, Scheiman J, Mycek MA. PMID: 24409383; PMCID: PMC3862164.
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    124. Minutes of the business meeting of the American Pancreatic Association, Friday, November 2, 2012, Miami, Florida. Pancreas. 2013 Nov; 42(8):1333-4. Liddle RA, Freeman M, Simeone DM, Saluja AK, Castillo CF, Maitra A, Pandol SJ, Go VL. PMID: 24152959; PMCID: PMC4912134.
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    125. HAb18G/CD147 promotes pSTAT3-mediated pancreatic cancer development via CD44s. Clin Cancer Res. 2013 Dec 15; 19(24):6703-15. Li L, Tang W, Wu X, Karnak D, Meng X, Thompson R, Hao X, Li Y, Qiao XT, Lin J, Fuchs J, Simeone DM, Chen ZN, Lawrence TS, Xu L. PMID: 24132924; PMCID: PMC3873783.
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    126. Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nat Nanotechnol. 2013 Oct; 8(10):735-41. Yoon HJ, Kim TH, Zhang Z, Azizi E, Pham TM, Paoletti C, Lin J, Ramnath N, Wicha MS, Hayes DF, Simeone DM, Nagrath S. PMID: 24077027; PMCID: PMC4017624.
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    127. Deciphering the role of stroma in pancreatic cancer. Curr Opin Gastroenterol. 2013 Sep; 29(5):537-43. Waghray M, Yalamanchili M, di Magliano MP, Simeone DM. PMID: 23892539; PMCID: PMC4112589.
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    128. Breast cancer metastases to the pancreas. J Gastrointest Surg. 2013 Oct; 17(10):1826-31. Bednar F, Scheiman JM, McKenna BJ, Simeone DM. PMID: 23918083.
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    129. SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells. Oncogenesis. 2013 Aug 05; 2:e61. Herreros-Villanueva M, Zhang JS, Koenig A, Abel EV, Smyrk TC, Bamlet WR, de Narvajas AA, Gomez TS, Simeone DM, Bujanda L, Billadeau DD. PMID: 23917223; PMCID: PMC3759123.
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    130. Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from nonmucinous pancreatic cysts. Mol Cell Proteomics. 2013 Oct; 12(10):2724-34. Cao Z, Maupin K, Curnutte B, Fallon B, Feasley CL, Brouhard E, Kwon R, West CM, Cunningham J, Brand R, Castelli P, Crippa S, Feng Z, Allen P, Simeone DM, Haab BB. PMID: 23836919; PMCID: PMC3790286.
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    131. Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res. 2013 Aug 01; 73(15):4909-22. Zhang Y, Morris JP, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M. PMID: 23761328; PMCID: PMC3763696.
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    132. Biology and clinical applications of pancreatic cancer stem cells. Gastroenterology. 2013 Jun; 144(6):1241-8. Abel EV, Simeone DM. PMID: 23622133.
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    133. The pancreas: biology, diseases, and therapy. Gastroenterology. 2013 Jun; 144(6):1163-5. Simeone DM, Pandol SJ. PMID: 23622124; PMCID: PMC4919811.
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    134. A multi-institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer. Cancer. 2013 Aug 01; 119(15):2692-700. Kim EJ, Ben-Josef E, Herman JM, Bekaii-Saab T, Dawson LA, Griffith KA, Francis IR, Greenson JK, Simeone DM, Lawrence TS, Laheru D, Wolfgang CL, Williams T, Bloomston M, Moore MJ, Wei A, Zalupski MM. PMID: 23720019; PMCID: PMC4174603.
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    135. Career track of Society of University Surgeons Resident Research Award recipients. J Surg Res. 2013 Nov; 185(1):92-6. Hassan B, Bernstam E, Hines OJ, Simeone DM, Weber SM, Geller DA, Evers BM, Meric-Bernstam F. PMID: 23751805; PMCID: PMC4346242.
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    136. Introduction for the IAP/APC symposium papers. Pancreatology. 2013 Mar-Apr; 13(2):101. Apte M, Simeone DM. PMID: 23561964.
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    137. Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma. PLoS One. 2013; 8(2):e55820. Proctor E, Waghray M, Lee CJ, Heidt DG, Yalamanchili M, Li C, Bednar F, Simeone DM. PMID: 23437065; PMCID: PMC3577834.
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    138. Outlier kinase expression by RNA sequencing as targets for precision therapy. Cancer Discov. 2013 Mar; 3(3):280-93. Kothari V, Wei I, Shankar S, Kalyana-Sundaram S, Wang L, Ma LW, Vats P, Grasso CS, Robinson DR, Wu YM, Cao X, Simeone DM, Chinnaiyan AM, Kumar-Sinha C. PMID: 23384775; PMCID: PMC3597439.
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    139. Protein kinase A modulates transforming growth factor-β signaling through a direct interaction with Smad4 protein. J Biol Chem. 2013 Mar 22; 288(12):8737-8749. Yang H, Li G, Wu JJ, Wang L, Uhler M, Simeone DM. PMID: 23362281; PMCID: PMC3605691.
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    140. The role of cytology in the preoperative assessment and management of patients with pancreaticobiliary tract neoplasms. J Gastrointest Surg. 2013 Mar; 17(3):501-10. Pang JC, Minter RM, Kwon RS, Simeone DM, Roh MH. PMID: 23297029.
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    141. Commentary: The role of global surgery electives during residency training: relevance, realities, and regulations. Surgery. 2013 Mar; 153(3):327-32. Axt J, Nthumba PM, Mwanzia K, Hansen E, Tarpley MJ, Krishnaswami S, Nwomeh BC, Holterman AX, Nadler EP, Simeone D, Orloff S, Tarpley JL, Merchant NB. PMID: 23274100.
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    142. Plasma Shh levels reduced in pancreatic cancer patients. Pancreas. 2012 Oct; 41(7):1019-28. El-Zaatari M, Daignault S, Tessier A, Kelsey G, Travnikar LA, Cantu EF, Lee J, Plonka CM, Simeone DM, Anderson MA, Merchant JL. PMID: 22513293; PMCID: PMC3404255.
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    143. Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells. Clin Cancer Res. 2012 Oct 01; 18(19):5374-86. Yen WC, Fischer MM, Hynes M, Wu J, Kim E, Beviglia L, Yeung VP, Song X, Kapoun AM, Lewicki J, Gurney A, Simeone DM, Hoey T. PMID: 22952347.
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    144. Emerging frontiers in pancreatic cancer research: elaboration of key genes, cells and the extracellular milieu. Curr Opin Gastroenterol. 2012 Sep; 28(5):516-22. Kumar-Sinha C, Wei I, Simeone DM. PMID: 22759592; PMCID: PMC3680108.
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    145. Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition. Neoplasia. 2012 Jun; 14(6):519-25. Venkatesha VA, Parsels LA, Parsels JD, Zhao L, Zabludoff SD, Simeone DM, Maybaum J, Lawrence TS, Morgan MA. PMID: 22787433; PMCID: PMC3394194.
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    146. An N-glycosylation Analysis of Human Alpha-2-Macroglobulin Using an Integrated Approach. J Proteomics Bioinform. 2012 May 31; 5:127-134. Lin Z, Lo A, Simeone DM, Ruffin MT, Lubman DM. PMID: 23028207; PMCID: PMC3460646.
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    147. Screening for depression, sleep-related disturbances, and anxiety in patients with adenocarcinoma of the pancreas: a preliminary study. ScientificWorldJournal. 2012; 2012:650707. Boyd AD, Brown D, Henrickson C, Hampton J, Zhu B, Almani F, Ben-Josef E, Zalupski M, Simeone DM, Taylor JM, Armitage R, Riba M. PMID: 22666142; PMCID: PMC3366237.
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    148. A phase I/II trial of intensity modulated radiation (IMRT) dose escalation with concurrent fixed-dose rate gemcitabine (FDR-G) in patients with unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys. 2012 Dec 01; 84(5):1166-71. Ben-Josef E, Schipper M, Francis IR, Hadley S, Ten-Haken R, Lawrence T, Normolle D, Simeone DM, Sonnenday C, Abrams R, Leslie W, Khan G, Zalupski MM. PMID: 22543215; PMCID: PMC3421048.
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    149. Comparison of surgical and endoscopic sample collection for pancreatic cyst fluid biomarker identification. J Proteome Res. 2012 May 04; 11(5):2904-11. Partyka K, McDonald M, Maupin KA, Brand R, Kwon R, Simeone DM, Allen P, Haab BB. PMID: 22439797; PMCID: PMC3345068.
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    150. Metformin and cancer stem cells: old drug, new targets. Cancer Prev Res (Phila). 2012 Mar; 5(3):351-4. Bednar F, Simeone DM. PMID: 22389436.
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    151. Identification of glycoprotein markers for pancreatic cancer CD24+CD44+ stem-like cells using nano-LC-MS/MS and tissue microarray. J Proteome Res. 2012 Apr 06; 11(4):2272-81. Zhu J, He J, Liu Y, Simeone DM, Lubman DM. PMID: 22335271; PMCID: PMC3321127.
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    152. Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers. PLoS One. 2011; 6(12):e29180. Yue T, Maupin KA, Fallon B, Li L, Partyka K, Anderson MA, Brenner DE, Kaul K, Zeh H, Moser AJ, Simeone DM, Feng Z, Brand RE, Haab BB. PMID: 22220206; PMCID: PMC3248411.
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    153. Pancreatic cancer stem cell biology and its therapeutic implications. J Gastroenterol. 2011 Dec; 46(12):1345-52. Bednar F, Simeone DM. PMID: 22048257.
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    154. 2011 American Pancreatic Association presidential address: demystifying the pancreas. Pancreas. 2011 Nov; 40(8):1163-4. Simeone DM. PMID: 22001829.
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    155. The use of protein-based biomarkers for the diagnosis of cystic tumors of the pancreas. Int J Proteomics. 2011; 2011:413646. Kwon RS, Simeone DM. PMID: 22110950; PMCID: PMC3202124.
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    156. Contemporary management of nonfunctioning pancreatic neuroendocrine tumors. J Gastrointest Surg. 2012 Feb; 16(2):435-46. Minter RM, Simeone DM. PMID: 22009463.
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    157. Advances in pancreatic cancer. Curr Opin Gastroenterol. 2011 Sep; 27(5):460-6. Kim EJ, Simeone DM. PMID: 21778878.
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    158. c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology. 2011 Dec; 141(6):2218-2227.e5. Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, Pasca di Magliano M, Simeone DM. PMID: 21864475.
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    159. A multiplexed bead assay for profiling glycosylation patterns on serum protein biomarkers of pancreatic cancer. Electrophoresis. 2011 Aug; 32(15):2028-35. Li C, Zolotarevsky E, Thompson I, Anderson MA, Simeone DM, Casper JM, Mullenix MC, Lubman DM. PMID: 21732554; PMCID: PMC3291473.
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    160. Assessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition. Clin Cancer Res. 2011 Jun 01; 17(11):3706-15. Parsels LA, Qian Y, Tanska DM, Gross M, Zhao L, Hassan MC, Arumugarajah S, Parsels JD, Hylander-Gans L, Simeone DM, Morosini D, Brown JL, Zabludoff SD, Maybaum J, Lawrence TS, Morgan MA. PMID: 21482692; PMCID: PMC3107893.
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    161. Is there still a glass ceiling for women in academic surgery? Ann Surg. 2011 Apr; 253(4):637-43. Zhuge Y, Kaufman J, Simeone DM, Chen H, Velazquez OC. PMID: 21475000.
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    162. Mass spectrometric assay for analysis of haptoglobin fucosylation in pancreatic cancer. J Proteome Res. 2011 May 06; 10(5):2602-11. Lin Z, Simeone DM, Anderson MA, Brand RE, Xie X, Shedden KA, Ruffin MT, Lubman DM. PMID: 21417406; PMCID: PMC3090531.
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    163. Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues. Opt Express. 2010 Oct 11; 18(21):21612-21. Wilson RH, Chandra M, Chen LC, Lloyd WR, Scheiman J, Simeone D, Purdy J, McKenna B, Mycek MA. PMID: 20941059; PMCID: PMC3408914.
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    164. Glycoprotein analysis using protein microarrays and mass spectrometry. Mass Spectrom Rev. 2010 Sep-Oct; 29(5):830-44. Patwa T, Li C, Simeone DM, Lubman DM. PMID: 20077480; PMCID: PMC2889184.
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    165. Reliable gene expression measurements from fine needle aspirates of pancreatic tumors: effect of amplicon length and quality assessment. J Mol Diagn. 2010 Sep; 12(5):566-75. Anderson MA, Brenner DE, Scheiman JM, Simeone DM, Singh N, Sikora MJ, Zhao L, Mertens AN, Rae JM. PMID: 20709792; PMCID: PMC2928420.
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    166. Mesenteric venous collateral vessels mimicking cystic pancreatic neoplasm. Br J Radiol. 2010 Aug; 83(992):e175-8. Sundaram B, Robbins JB, Zeglis MD, Scheiman JM, Simeone DM, Francis IR. PMID: 20675462; PMCID: PMC3473515.
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    167. Quantitative proteomic profiling studies of pancreatic cancer stem cells. J Proteome Res. 2010 Jul 02; 9(7):3394-402. Dai L, Li C, Shedden KA, Lee CJ, Li C, Quoc H, Simeone DM, Lubman DM. PMID: 20486718; PMCID: PMC2906393.
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    168. In vivo bioluminescent imaging of irradiated orthotopic pancreatic cancer xenografts in nonobese diabetic-severe combined immunodeficient mice: a novel method for targeting and assaying efficacy of ionizing radiation. Transl Oncol. 2010 Jun 01; 3(3):153-9. Lee CJ, Spalding AC, Ben-Josef E, Wang L, Simeone DM. PMID: 20563256; PMCID: PMC2887644.
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    169. Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res. 2010 Jun 15; 70(12):4972-81. Morgan MA, Parsels LA, Zhao L, Parsels JD, Davis MA, Hassan MC, Arumugarajah S, Hylander-Gans L, Morosini D, Simeone DM, Canman CE, Normolle DP, Zabludoff SD, Maybaum J, Lawrence TS. PMID: 20501833; PMCID: PMC2889008.
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    170. Pancreatic cancer and hedgehog pathway signaling: new insights. Pancreatology. 2010; 10(2-3):151-7. Dosch JS, Pasca di Magliano M, Simeone DM. PMID: 20453550; PMCID: PMC7075422.
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    171. Glycosylation variants of mucins and CEACAMs as candidate biomarkers for the diagnosis of pancreatic cystic neoplasms. Ann Surg. 2010 May; 251(5):937-45. Haab BB, Porter A, Yue T, Li L, Scheiman J, Anderson MA, Barnes D, Schmidt CM, Feng Z, Simeone DM. PMID: 20395854; PMCID: PMC3713623.
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    172. New frontiers in pancreatic cancer research. Surg Oncol Clin N Am. 2010 Apr; 19(2):431-51. Khan GN, di Magliano MP, Simeone DM. PMID: 20159524.
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    173. Spectral areas and ratios classifier algorithm for pancreatic tissue classification using optical spectroscopy. J Biomed Opt. 2010 Jan-Feb; 15(1):010514. Chandra M, Scheiman J, Simeone D, McKenna B, Purdy J, Mycek MA. PMID: 20210425; PMCID: PMC2839796.
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    174. The identification of auto-antibodies in pancreatic cancer patient sera using a naturally fractionated Panc-1 cell line. Cancer Biomark. 2010; 7(1):25-37. Li C, Kim HY, Vuong H, Patwa T, Pal M, Brand RE, Simeone DM, Lubman DM. PMID: 21045262; PMCID: PMC3130890.
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    175. Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. J Clin Oncol. 2009 Nov 20; 27(33):5660-9. Philip PA, Mooney M, Jaffe D, Eckhardt G, Moore M, Meropol N, Emens L, O'Reilly E, Korc M, Ellis L, Benedetti J, Rothenberg M, Willett C, Tempero M, Lowy A, Abbruzzese J, Simeone D, Hingorani S, Berlin J, Tepper J. PMID: 19858397; PMCID: PMC7587401.
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    176. Optical spectroscopy detects histological hallmarks of pancreatic cancer. Opt Express. 2009 Sep 28; 17(20):17502-16. Wilson RH, Chandra M, Scheiman J, Simeone D, McKenna B, Purdy J, Mycek MA. PMID: 19907534.
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    177. Long-term follow-up of patients with incidentally discovered pancreatic cystic neoplasms evaluated by endoscopic ultrasound. Surgery. 2010 Jan; 147(1):13-20. Pausawasdi N, Heidt D, Kwon R, Simeone D, Scheiman J. PMID: 19767045.
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    178. The evolution of the SUS. Surgery. 2009 Aug; 146(2):131-7. Simeone DM. PMID: 19628066.
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    179. Cancer stem cells: a new theory regarding a timeless disease. Chem Rev. 2009 Jul; 109(7):3200-8. Sarkar B, Dosch J, Simeone DM. PMID: 19522504.
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    180. Pancreatic cancer patients who smoke and drink are diagnosed at younger ages. Clin Gastroenterol Hepatol. 2009 Sep; 7(9):1007-12. Brand RE, Greer JB, Zolotarevsky E, Brand R, Du H, Simeone D, Zisman A, Gorchow A, Lee SY, Roy HK, Anderson MA. PMID: 19560558; PMCID: PMC2736339.
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    181. The identification of phosphoglycerate kinase-1 and histone H4 autoantibodies in pancreatic cancer patient serum using a natural protein microarray. Electrophoresis. 2009 Jun; 30(12):2215-26. Patwa TH, Li C, Poisson LM, Kim HY, Pal M, Ghosh D, Simeone DM, Lubman DM. PMID: 19582723; PMCID: PMC2794663.
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    182. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood. 2009 Aug 06; 114(6):1141-9. Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu R, Zou W. PMID: 19470694; PMCID: PMC2723011.
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    183. Gemcitabine-based combination chemotherapy followed by radiation with capecitabine as adjuvant therapy for resected pancreas cancer. Int J Radiat Oncol Biol Phys. 2009 Dec 01; 75(5):1450-5. Desai S, Ben-Josef E, Griffith KA, Simeone D, Greenson JK, Francis IR, Hampton J, Colletti L, Chang AE, Lawrence TS, Zalupski MM. PMID: 19409732.
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    184. Pancreatic cancer stem cells and relevance to cancer treatments. J Cell Biochem. 2009 May 01; 107(1):40-5. Bednar F, Simeone DM. PMID: 19301275.
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    185. FOXP3 defines regulatory T cells in human tumor and autoimmune disease. Cancer Res. 2009 May 01; 69(9):3995-4000. Kryczek I, Liu R, Wang G, Wu K, Shu X, Szeliga W, Vatan L, Finlayson E, Huang E, Simeone D, Redman B, Welling TH, Chang A, Zou W. PMID: 19383912.
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    186. Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. Cancer Cell. 2009 Mar 03; 15(3):207-19. Wang L, Heidt DG, Lee CJ, Yang H, Logsdon CD, Zhang L, Fearon ER, Ljungman M, Simeone DM. PMID: 19249679; PMCID: PMC2673547.
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    187. Pancreatic cancer serum detection using a lectin/glyco-antibody array method. J Proteome Res. 2009 Feb; 8(2):483-92. Li C, Simeone DM, Brenner DE, Anderson MA, Shedden KA, Ruffin MT, Lubman DM. PMID: 19072160; PMCID: PMC2637303.
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    188. All-liquid separations, protein microarrays, and mass spectrometry to interrogate serum proteomes: an application to serum glycoproteomics. Methods Mol Biol. 2009; 520:75-87. Patwa TH, Qiu Y, Zhao J, Simeone DM, Lubman DM. PMID: 19381948.
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    189. Identification of human pancreatic cancer stem cells. Methods Mol Biol. 2009; 568:161-73. Li C, Lee CJ, Simeone DM. PMID: 19582426.
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    190. Protein biomarkers in cancer: natural glycoprotein microarray approaches. Curr Opin Mol Ther. 2008 Dec; 10(6):602-10. Zhao J, Patwa TH, Lubman DM, Simeone DM. PMID: 19051138; PMCID: PMC2920894.
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    191. Pancreatic cancer stem cells: implications for the treatment of pancreatic cancer. Clin Cancer Res. 2008 Sep 15; 14(18):5646-8. Simeone DM. PMID: 18794070.
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    192. Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer. Proteomics. 2008 Aug; 8(15):3051-60. Grote T, Siwak DR, Fritsche HA, Joy C, Mills GB, Simeone D, Whitcomb DC, Logsdon CD. PMID: 18615426; PMCID: PMC2992687.
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    193. Pancreatic cancer stem cells. J Clin Oncol. 2008 Jun 10; 26(17):2806-12. Lee CJ, Dosch J, Simeone DM. PMID: 18539958.
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    194. Regulation of transforming growth factor beta-induced responses by protein kinase A in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2008 Jul; 295(1):G170-G178. Yang H, Lee CJ, Zhang L, Sans MD, Simeone DM. PMID: 18467503; PMCID: PMC2494718.
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    195. Enhanced detection of autoantibodies on protein microarrays using a modified protein digestion technique. J Proteome Res. 2008 Jun; 7(6):2553-61. Patwa TH, Wang Y, Simeone DM, Lubman DM. PMID: 18452326; PMCID: PMC2649732.
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    196. "Criminal" profiling of the pancreas: when is aggressive therapy indicated for a non-aggressive entity? Ann Surg. 2008 Apr; 247(4):580-2. Sonnenday CJ, Simeone DM. PMID: 18362620.
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    197. Human pancreatic cancer stem cells: implications for how we treat pancreatic cancer. Transl Oncol. 2008 Mar; 1(1):14-8. Lee CJ, Li C, Simeone DM. PMID: 18607507; PMCID: PMC2510763.
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    198. SSAT/AGA/ASGE state of the art conference on cystic neoplasms of the pancreas. J Gastrointest Surg. 2008 Aug; 12(8):1475-7. Simeone DM. PMID: 18224378.
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    199. Risk of malignancy in resected cystic tumors of the pancreas < or =3 cm in size: is it safe to observe asymptomatic patients? A multi-institutional report. J Gastrointest Surg. 2008 Feb; 12(2):234-42. Lee CJ, Scheiman J, Anderson MA, Hines OJ, Reber HA, Farrell J, Kochman ML, Foley PJ, Drebin J, Oh YS, Ginsberg G, Ahmad N, Merchant NB, Isbell J, Parikh AA, Stokes JB, Bauer T, Adams RB, Simeone DM. PMID: 18040749.
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    200. Early detection and biomarkers in pancreatic cancer. J Natl Compr Canc Netw. 2007 Nov; 5(10):1034-41. Misek DE, Patwa TH, Lubman DM, Simeone DM. PMID: 18053427.
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    201. Probing pancreatic disease using tissue optical spectroscopy. J Biomed Opt. 2007 Nov-Dec; 12(6):060501. Chandra M, Scheiman J, Heidt D, Simeone D, McKenna B, Mycek MA. PMID: 18163796.
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    202. Phase I study of oxaliplatin, full-dose gemcitabine, and concurrent radiation therapy in pancreatic cancer. J Clin Oncol. 2007 Oct 10; 25(29):4587-92. Desai SP, Ben-Josef E, Normolle DP, Francis IR, Greenson JK, Simeone DM, Chang AE, Colletti LM, Lawrence TS, Zalupski MM. PMID: 17925553.
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    203. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2007 Jun 12; 104(24):10158-63. Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF. PMID: 17548814; PMCID: PMC1891215.
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    204. CEACAM1, a novel serum biomarker for pancreatic cancer. Pancreas. 2007 May; 34(4):436-43. Simeone DM, Ji B, Banerjee M, Arumugam T, Li D, Anderson MA, Bamberger AM, Greenson J, Brand RE, Ramachandran V, Logsdon CD. PMID: 17446843.
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    205. Glycoprotein microarrays with multi-lectin detection: unique lectin binding patterns as a tool for classifying normal, chronic pancreatitis and pancreatic cancer sera. J Proteome Res. 2007 May; 6(5):1864-74. Zhao J, Patwa TH, Qiu W, Shedden K, Hinderer R, Misek DE, Anderson MA, Simeone DM, Lubman DM. PMID: 17428079.
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    206. Multiplexed analysis of glycan variation on native proteins captured by antibody microarrays. Nat Methods. 2007 May; 4(5):437-44. Chen S, LaRoche T, Hamelinck D, Bergsma D, Brenner D, Simeone D, Brand RE, Haab BB. PMID: 17417647.
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    207. Cancer stem cells: a new paradigm for understanding tumor progression and therapeutic resistance. Surgery. 2007 Apr; 141(4):415-9. Huang EH, Heidt DG, Li CW, Simeone DM. PMID: 17383517.
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    208. Characterization of apolipoprotein and apolipoprotein precursors in pancreatic cancer serum samples via two-dimensional liquid chromatography and mass spectrometry. J Chromatogr A. 2007 Aug 31; 1162(2):117-25. Chen J, Anderson M, Misek DE, Simeone DM, Lubman DM. PMID: 17434173; PMCID: PMC2692198.
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    209. Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR. Cancer Res. 2007 Mar 15; 67(6):2666-75. Ramachandran V, Arumugam T, Hwang RF, Greenson JK, Simeone DM, Logsdon CD. PMID: 17363587.
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    210. Identification of pancreatic cancer stem cells. Cancer Res. 2007 Feb 01; 67(3):1030-7. Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF, Simeone DM. PMID: 17283135.
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    211. Total pancreatectomy: indications, operative technique, and postoperative sequelae. J Gastrointest Surg. 2007 Feb; 11(2):209-16. Heidt DG, Burant C, Simeone DM. PMID: 17390175.
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    212. N-linked glycosylation profiling of pancreatic cancer serum using capillary liquid phase separation coupled with mass spectrometric analysis. J Proteome Res. 2007 Mar; 6(3):1126-38. Zhao J, Qiu W, Simeone DM, Lubman DM. PMID: 17249709.
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    213. Screening of glycosylation patterns in serum using natural glycoprotein microarrays and multi-lectin fluorescence detection. Anal Chem. 2006 Sep 15; 78(18):6411-21. Patwa TH, Zhao J, Anderson MA, Simeone DM, Lubman DM. PMID: 16970316.
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    214. Automated integration of monolith-based protein separation with on-plate digestion for mass spectrometric analysis of esophageal adenocarcinoma human epithelial samples. Electrophoresis. 2006 Sep; 27(18):3643-51. Yoo C, Zhao J, Pal M, Hersberger K, Huber CG, Simeone DM, Beer DG, Lubman DM. PMID: 16927349.
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    215. Comparative serum glycoproteomics using lectin selected sialic acid glycoproteins with mass spectrometric analysis: application to pancreatic cancer serum. J Proteome Res. 2006 Jul; 5(7):1792-802. Zhao J, Simeone DM, Heidt D, Anderson MA, Lubman DM. PMID: 16823988.
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    216. Adjuvant treatment strategies for pancreatic cancer. J Gastrointest Surg. 2006 Jun; 10(6):916-26. Newman EA, Simeone DM, Mulholland MW. PMID: 16769552.
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    217. Islet hypertrophy following pancreatic disruption of Smad4 signaling. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1305-16. Simeone DM, Zhang L, Treutelaar MK, Zhang L, Graziano K, Logsdon CD, Burant CF. PMID: 16735447.
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    218. Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer. Cancer Res. 2006 Jan 15; 66(2):898-906. Zhang L, Chenwei L, Mahmood R, van Golen K, Greenson J, Li G, D'Silva NJ, Li X, Burant CF, Logsdon CD, Simeone DM. PMID: 16424023.
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    219. Identification of a Specific Vimentin Isoform That Induces an Antibody Response in Pancreatic Cancer. Biomark Insights. 2006; 1:175-183. Hong SH, Misek DE, Wang H, Puravs E, Hinderer R, Giordano TJ, Greenson JK, Brenner DE, Simeone DM, Logsdon CD, Hanash SM. PMID: 18769604; PMCID: PMC2528299.
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    220. S100P promotes pancreatic cancer growth, survival, and invasion. Clin Cancer Res. 2005 Aug 01; 11(15):5356-64. Arumugam T, Simeone DM, Van Golen K, Logsdon CD. PMID: 16061848.
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    221. The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma. Pancreas. 2004 Nov; 29(4):254-63. Binkley CE, Zhang L, Greenson JK, Giordano TJ, Kuick R, Misek D, Hanash S, Logsdon CD, Simeone DM. PMID: 15502640.
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    222. Raf kinase inhibitory protein inhibits beta-cell proliferation. Surgery. 2004 Sep; 136(3):708-15. Zhang L, Fu Z, Binkley C, Giordano T, Burant CF, Logsdon CD, Simeone DM. PMID: 15349122.
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    223. Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res. 2004 Aug 01; 64(15):5338-46. Okami J, Simeone DM, Logsdon CD. PMID: 15289340.
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    224. An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer. Cancer Res. 2004 Aug 01; 64(15):5504-10. Hong SH, Misek DE, Wang H, Puravs E, Giordano TJ, Greenson JK, Brenner DE, Simeone DM, Logsdon CD, Hanash SM. PMID: 15289361.
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    225. A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A. Mol Cell Biol. 2004 Mar; 24(5):2169-80. Zhang L, Duan CJ, Binkley C, Li G, Uhler MD, Logsdon CD, Simeone DM. PMID: 14966294; PMCID: PMC350541.
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    226. Increased MMP-9 expression and activity by aortic smooth muscle cells after nitric oxide synthase inhibition is associated with increased nuclear factor-kappaB and activator protein-1 activity. J Surg Res. 2004 Jan; 116(1):70-80. Knipp BS, Ailawadi G, Ford JW, Peterson DA, Eagleton MJ, Roelofs KJ, Hannawa KK, Deogracias MP, Ji B, Logsdon C, Graziano KD, Simeone DM, Thompson RW, Henke PK, Stanley JC, Upchurch GR. PMID: 14732351.
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    227. S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). J Biol Chem. 2004 Feb 13; 279(7):5059-65. Arumugam T, Simeone DM, Schmidt AM, Logsdon CD. PMID: 14617629.
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    228. Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework. Am J Pathol. 2003 Nov; 163(5):1985-95. Shedden KA, Taylor JM, Giordano TJ, Kuick R, Misek DE, Rennert G, Schwartz DR, Gruber SB, Logsdon C, Simeone D, Kardia SL, Greenson JK, Cho KR, Beer DG, Fearon ER, Hanash S. PMID: 14578198; PMCID: PMC1892445.
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    229. Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes. 2003 Oct; 52(10):2503-12. Treutelaar MK, Skidmore JM, Dias-Leme CL, Hara M, Zhang L, Simeone D, Martin DM, Burant CF. PMID: 14514633.
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    230. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res. 2003 May 15; 63(10):2649-57. Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson JK, Giordano TJ, Misek DE, Kuick R, Hanash S. PMID: 12750293.
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    231. Human pancreatic acinar cells do not respond to cholecystokinin. Pharmacol Toxicol. 2002 Dec; 91(6):327-32. Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD. PMID: 12688376.
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    232. Bacillus anthracis as an agent of bioterrorism: a review emphasizing surgical treatment. Ann Surg. 2002 Jul; 236(1):9-16. Binkley CE, Cinti S, Simeone DM, Colletti LM. PMID: 12131080; PMCID: PMC1422543.
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    233. Connecting islet development and developing useful islets. Trends Endocrinol Metab. 2002 Mar; 13(2):48-9. Burant CF, Simeone DM. PMID: 11854014.
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    234. NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology. 2002 Feb; 122(2):448-57. Chen X, Ji B, Han B, Ernst SA, Simeone D, Logsdon CD. PMID: 11832459.
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    235. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology. 2001 Dec; 121(6):1380-90. Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD. PMID: 11729117.
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    236. Characterization of the inflammatory infiltrate in peptic oesophagitis. Dig Liver Dis. 2001 Aug-Sep; 33(6):452-8. Tozzi A, Staiano A, Paparo F, Miele E, Maglio M, Di Meo M, Simeone D, Troncone R. PMID: 11572570.
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    237. Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells. Am J Physiol Cell Physiol. 2001 Jul; 281(1):C311-9. Simeone DM, Zhang L, Graziano K, Nicke B, Pham T, Schaefer C, Logsdon CD. PMID: 11401854.
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    238. Doctor-patient communication in surgery: attitudes and expectations of general surgery patients about the involvement and education of surgical residents. J Am Coll Surg. 2001 Jul; 193(1):73-80. Cowles RA, Moyer CA, Sonnad SS, Simeone DM, Knol JA, Eckhauser FE, Mulholland MW, Colletti LM. PMID: 11442257.
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    239. Adenovirus-mediated gene transfer of dominant-negative Smad4 blocks TGF-beta signaling in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2001 Jun; 280(6):G1247-53. Zhang L, Graziano K, Pham T, Logsdon CD, Simeone DM. PMID: 11352818.
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    240. The "serendipitous" surgical cure of the Zollinger-Ellison syndrome in a patient with multiple endocrine neoplasia type 1 despite an unsuspected diagnosis of either disease. J Clin Gastroenterol. 2001 Mar; 32(3):268-71. Simeone DM, Scheiman JM, Thompson NW. PMID: 11246362.
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    241. Disruption of TGFbeta signaling pathways in human pancreatic cancer cells. Ann Surg. 2000 Jul; 232(1):73-80. Simeone DM, Pham T, Logsdon CD. PMID: 10862198; PMCID: PMC1421110.
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    242. Giant peptic ulcer: a surgical or medical disease? Surgery. 1999 Sep; 126(3):474-8. Simeone DM, Hassan A, Scheiman JM. PMID: 10486598.
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    243. Images in clinical medicine. Mesenteric cyst. N Engl J Med. 1999 Aug 26; 341(9):659. Simeone DM, Pranikoff T. PMID: 10460817.
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    244. Adenoviral-mediated gene transfer of a constitutively active retinoblastoma gene inhibits human pancreatic tumor cell proliferation. Surgery. 1997 Aug; 122(2):428-33; discussion 433-4. Simeone DM, Cascarelli A, Logsdon CD. PMID: 9288150.
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    245. Riedel's thyroiditis: treatment with tamoxifen. Surgery. 1996 Dec; 120(6):993-8; discussion 998-9. Few J, Thompson NW, Angelos P, Simeone D, Giordano T, Reeve T. PMID: 8957485.
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    246. Blunt force injury of the abdominal aorta. J Trauma. 1996 Jul; 41(1):105-9. Michaels AJ, Gerndt SJ, Taheri PA, Wang SC, Wahl WL, Simeone DM, Williams DM, Greenfield LJ, Rodriguez JL. PMID: 8676400.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    247. Acetylcholine-induced calcium signaling associated with muscarinic receptor activation in cultured myenteric neurons. J Am Coll Surg. 1996 Jun; 182(6):473-81. Simeone DM, Kimball BC, Mulholland MW. PMID: 8646346.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    248. Undescended superior parathyroid gland: a potential cause of failed cervical exploration for hyperparathyroidism. Surgery. 1995 Dec; 118(6):949-56. Simeone DM, Sandelin K, Thompson NW. PMID: 7491539.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    249. Ca2+ signaling through secretagogue and growth factor receptors on pancreatic AR42J cells. Regul Pept. 1995 Jan 26; 55(2):197-206. Simeone DM, Yule DI, Logsdon CD, Williams JA. PMID: 7538685.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    250. Bombesin-mediated calcium fluxes in myenteric plexus neurons. Peptides. 1995; 16(7):1307-11. Simeone DM, Kimball BC, Mulholland MW. PMID: 8545256.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    251. Nerve growth factor promotes neurite outgrowth in guinea pig myenteric plexus ganglia. Am J Physiol. 1994 Oct; 267(4 Pt 1):G716-22. Mulholland MW, Romanchuk G, Lally K, Simeone DM. PMID: 7943336.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    252. Dual pathways regulate neurite outgrowth in enteric ganglia. Am J Physiol. 1994 Oct; 267(4 Pt 1):G723-9. Simeone DM, Romanchuk G, Mulholland MW. PMID: 7943337.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    253. Prostaglandin E2 stimulation of acetylcholine release from guinea pig myenteric plexus neurons. Am J Surg. 1993 Nov; 166(5):552-6. Mulholland MW, Simeone DM. PMID: 7694514.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    254. Bombesin-stimulated acetylcholine release from myenteric plexus neurons. J Surg Res. 1993 May; 54(5):389-92. Mulholland MW, Simeone DM. PMID: 8361163.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    255. Bone lesions in Langerhans cell histiocytosis. Clin Pediatr (Phila). 1993 Feb; 32(2):118-20. Fiorillo A, Sadile F, De Chiara C, Parasole R, Simeone D, D'Amore R, D'Alvano L, Cigala F. PMID: 8432075.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    256. Stimulation of myenteric plexus neurite outgrowth by insulin and insulin-like growth factors I and II. Life Sci. 1992; 51(23):1789-96. Mulholland MW, Romanchuk G, Simeone DM, Flowe K. PMID: 1435087.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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