The Goren Lab focuses on epigenomic mechanisms, and merges basic biology, technological innovations and computational analyses. Our major interest is in developmental-epigenomic questions, and includes the employment and innovation of tools to study chromatin in uncharted settings, such as investigating the organization of chromatin regulatory networks during embryogenesis.
Our interdisciplinary group focuses on characterizing the dynamics and roles of chromatin regulators (CRs) and other components of epigenetic regulatory circuits in governing mammalian early development and during the cell cycle. Specifically, we focus on human and mouse ES cells and investigate mechanisms such as crosstalk between CRs and transcription factors for recruitment of CRs to specific genomic loci and the role these mechanisms play in cellular fate decisions. Further, we study the relevance of in vitro model systems (e.g., ES and iPS cells) and discrepancies with in vivo epigenomic programs.
For additional details see the lab website - goren-lab.github.io.