Alon Goren

Title(s)	Associate Professor, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

Hebrew University, Jerusalem, Israel

Ph.D.

Medical Sciences

Overview

The Goren Lab focuses on epigenomic mechanisms, and merges basic biology, technological innovations and computational analyses. Our major interest is in developmental-epigenomic questions, and includes the employment and innovation of tools to study chromatin in uncharted settings, such as investigating the organization of chromatin regulatory networks during embryogenesis.

Our interdisciplinary group focuses on characterizing the dynamics and roles of chromatin regulators (CRs) and other components of epigenetic regulatory circuits in governing mammalian early development and during the cell cycle. Specifically, we focus on human and mouse ES cells and investigate mechanisms such as crosstalk between CRs and transcription factors for recruitment of CRs to specific genomic loci and the role these mechanisms play in cellular fate decisions. Further, we study the relevance of in vitro model systems (e.g., ES and iPS cells) and discrepancies with in vivo epigenomic programs.

For additional details see the lab website - goren-lab.github.io.

Websites

Goren Lab

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Polymorphic short tandem repeats make widespread contributions to blood and serum traits. Cell Genom. 2023 Dec 13; 3(12):100458. Margoliash J, Fuchs S, Li Y, Zhang X, Massarat A, Goren A, Gymrek M. PMID: 38116119; PMCID: PMC10726533.

View in: PubMed Mentions: 8 Fields:
Gen Genetics
A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice. Genome Res. 2023 May; 33(5):689-702. Maksimov MO, Wu C, Ashbrook DG, Villani F, Colonna V, Mousavi N, Ma N, Lu L, Pritchard JK, Goren A, Williams RW, Palmer AA, Gymrek M. PMID: 37127331; PMCID: PMC10317118.

View in: PubMed Mentions: 2 Fields:
Gen Genetics
Translation:Animals Cells
The use of base editing technology to characterize single nucleotide variants. Comput Struct Biotechnol J. 2022; 20:1670-1680. McDaniel S, Komor A, Goren A. PMID: 35465164; PMCID: PMC9010703.

View in: PubMed Mentions: 2
Missing heritability may be hiding in repeats. Science. 2021 Sep 24; 373(6562):1440-1441. Gymrek M, Goren A. PMID: 34554784.

View in: PubMed Mentions: 4 Fields:
Sci Science
A flexible ChIP-sequencing simulation toolkit. BMC Bioinformatics. 2021 Apr 20; 22(1):201. Zheng A, Lamkin M, Qiu Y, Ren K, Goren A, Gymrek M. PMID: 33879052; PMCID: PMC8056602.

View in: PubMed Mentions: 2 Fields:
Com Computational Biology
The impact of short tandem repeat variation on gene expression. Nat Genet. 2019 11; 51(11):1652-1659. Fotsing SF, Margoliash J, Wang C, Saini S, Yanicky R, Shleizer-Burko S, Goren A, Gymrek M. PMID: 31676866; PMCID: PMC6917484.

View in: PubMed Mentions: 92 Fields:
Gen Genetics
Translation:Humans Cells