Robert Saddawi-konefka

Photo of Robert Saddawi-konefka
Title(s)Assistant Professor In Residence, Otolaryngology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-9936-1695 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Exploiting the CXCR3/CXCL10 axis overrides tumor immune suppression by enhancing immune trafficking and effector cell priming in HNSCC. Proc Natl Acad Sci U S A. 2026 Aug 25; 123(34):e2522360123. Shinn CK, Saddawi-Konefka R, Salanga CL, Schokrpur S, Gutkind JS, Handel TM. PMID: 42607203; PMCID: PMC13505983.
      View in: PubMed   Mentions:
    2. Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer. Cell. 2026 Aug 05. Naara S, Kochat V, Rao X, Arslan E, Saddawi-Konefka R, Satpati S, Garbarino J, Anderson JL, Gleber-Netto FO, Nagarajan P, Kerr TD, Akhter S, Li S, Fodor R, Koyfman SA, Yaniv D, Xie T, Glaun M, Bobian M, Padron WI, Ng C, Gunaratne PH, Thevasagayampillai S, Migden MR, Abbas HA, Reville PK, Tsai KY, McGrail DJ, Wang J, Myers JN, Gross ND, Rai K, Amit M. PMID: 42556334.
      View in: PubMed   Mentions:    Fields:    
    3. Cancer-induced neuronal injury as a driver of immunotherapy resistance. Immunotherapy. 2026 Apr-Apr; 18(5-6):351-353. Vu Y, Saddawi-Konefka R, Amit M. PMID: 42152623; PMCID: PMC13271265.
      View in: PubMed   Mentions:    Fields:    
    4. CD47 blockade (ALX301) enhances immunoradiotherapy response in HPV negative head and neck squamous cell carcinoma. PLoS One. 2026; 21(2):e0328031. Monther A, Al-Msari R, Saddawi-Konefka R, Fassardi S, Tang C, Philips C, Sen P, Mohammadzadeh P, Decker K, Miyauchi S, Roy S, Jones R, Wu X, Gutkind S, Sharabi A, Califano J. PMID: 41701713; PMCID: PMC12912607.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. β-Adrenergic Signaling Promotes Anti-Tumor Immunity in TP53-mutant Oral Squamous Cell Carcinoma. Adv Sci (Weinh). 2026 Jun; 13(35):e16859. Gleber-Netto FO, Silverman D, Xie T, Akhter S, Vaughn NR, Adebayo A, Debnath KC, Naara S, Islam S, Knutsen E, Ashkin EL, Anfossi S, Leahey S, Hwu P, Talbot S, Sloan EK, Saddawi-Konefka R, Rangel R, Myers JN, Calin GA, Amit M. PMID: 41665072; PMCID: PMC13292172.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Interactions of Antibody Drug Conjugate Anti-Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy. Adv Sci (Weinh). 2026 Jun; 13(35):e06552. Lesperance J, Yung BS, Allevato MM, Cheng MM, Camargo MF, Saddawi-Konefka R, Dhawan K, Sharma AK, Mortaja M, Bice S, Scanderbeg DJ, Alvarado D, Mayadev J, Eskander RN, Adams SR, Cosper PF, Gutkind JS, Advani SJ. PMID: 41133986; PMCID: PMC13292169.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. In vivo CRISPR screening in head and neck cancer reveals Uchl5 as an immunotherapy target. Nat Commun. 2025 Sep 29; 16(1):8572. Fu C, Saddawi-Konefka R, Chinai JM, Kim SY, Kammula AV, Perera JJ, Jiang A, Tiwari P, Kistler EN, Tang S, Luna SM, Colvin KJ, Dubrot J, Anderson S, Fetterman RA, Chuong CL, Lane-Reticker SK, Cheruiyot CK, Muscato AJ, Alipour Z, Adkins DR, Griffin GK, Bernstein BE, Egloff AM, Yates KB, Chernock RD, Gutkind JS, Uppaluri R, Manguso RT. PMID: 41022734; PMCID: PMC12480505.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma. Nat Commun. 2025 Sep 01; 16(1):8161. Wang B, Saddawi-Konefka R, Clubb LM, Tang S, Wu D, Mukherjee S, Sahni S, Dhruba SR, Yang X, Patiyal S, Day CP, Desai PA, Allen C, Wang K, Gutkind JS, Ruppin E. PMID: 40890155; PMCID: PMC12402333.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    9. The tumor-sentinel lymph node immuno-migratome reveals CCR7⁺ dendritic cells drive response to sequenced immunoradiotherapy. Nat Commun. 2025 Jul 17; 16(1):6578. Saddawi-Konefka R, Msari RA, Tang S, Philips C, Sadat S, Clubb LM, Luna S, Fassardi S, Jones R, Pietryga IF, Faraji F, Schokrpur S, Yung BS, Allevato MM, Decker KE, Nasamran CA, Chilin-Fuentes D, Rosenthal SB, Jensen SM, Fox BA, Bell RB, Gutkind JS, Sharabi A, Califano JA. PMID: 40675962; PMCID: PMC12271439.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. CBD promotes antitumor activity by modulating tumor immune microenvironment in HPV associated head and neck squamous cell carcinoma. Front Immunol. 2025; 16:1528520. Sen P, Sadat S, Ebisumoto K, Al-Msari R, Miyauchi S, Roy S, Mohammadzadeh P, Lips K, Nakagawa T, Saddawi-Konefka R, Sharabi AB, Califano JA. PMID: 40475776; PMCID: PMC12137345.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Activating the CXCR3/CXCL10 pathway overrides tumor immune suppression by enhancing immune trafficking and effector cell priming in head and neck squamous cell carcinoma. bioRxiv. 2025 May 06. Shinn CK, Saddawi-Konefka R, Salanga CL, Schokrpur S, Gutkind JS, Handel TM. PMID: 40654682; PMCID: PMC12247914.
      View in: PubMed   Mentions: 1  
    12. The XCL1-XCR1 axis supports intestinal tissue residency and antitumor immunity. J Exp Med. 2025 Mar 03; 222(2). Ferry A, Mempel KM, Monell A, Reina-Campos M, Scharping NE, Heeg M, Takehara KK, Schokrpur S, Kuo N, Saddawi-Konefka R, Gutkind JS, Goldrath AW. PMID: 39841133; PMCID: PMC11753173.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Let it be: Preserving tumor-draining lymph nodes in the era of immuno-oncology. Cancer Cell. 2024 06 10; 42(6):930-933. Saddawi-Konefka R, Schokrpur S, Gutkind JS. PMID: 38861928.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    14. CHMP2A regulates broad immune cell-mediated antitumor activity in an immunocompetent in vivo head and neck squamous cell carcinoma model. J Immunother Cancer. 2024 May 03; 12(5). Yun J, Saddawi-Konefka R, Goldenson B, Al-Msari R, Bernareggi D, Thangaraj JL, Tang S, Patel SH, Luna SM, Gutkind JS, Kaufman D. PMID: 38702144; PMCID: PMC11086353.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma. Cell Rep Med. 2023 11 21; 4(11):101244. Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, Krogan NJ, Yang J, Coma S, Pachter JA, Aplin AE, Alessi DR, Thomas CJ, Gutkind JS. PMID: 37858338; PMCID: PMC10694608.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    16. Simulation-based workshop for emergency preparedness in otolaryngology. Laryngoscope Investig Otolaryngol. 2023 Oct; 8(5):1159-1168. La Monte OA, Lee JH, Soliman SI, Saddawi-Konefka R, Harris JP, Coffey CS, Orosco RK, Watson D, Holliday MA, Faraji F, Hom DB. PMID: 37899850; PMCID: PMC10601586.
      View in: PubMed   Mentions: 3  
    17. The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure. Nat Immunol. 2023 08; 24(8):1318-1330. Wu VH, Yung BS, Faraji F, Saddawi-Konefka R, Wang Z, Wenzel AT, Song MJ, Pagadala MS, Clubb LM, Chiou J, Sinha S, Matic M, Raimondi F, Hoang TS, Berdeaux R, Vignali DAA, Iglesias-Bartolome R, Carter H, Ruppin E, Mesirov JP, Gutkind JS. PMID: 37308665; PMCID: PMC10735169.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    18. HER2 and HER3 as Therapeutic Targets in Head and Neck Cancer. Cancer J. 2022 Sep-Oct 01; 28(5):339-345. Saddawi-Konefka R, Schokrpur S, Lui AJ, Gutkind JS. PMID: 36165721; PMCID: PMC9523502.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    19. Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC. Nat Commun. 2022 07 25; 13(1):4298. Saddawi-Konefka R, O'Farrell A, Faraji F, Clubb L, Allevato MM, Jensen SM, Yung BS, Wang Z, Wu VH, Anang NA, Msari RA, Schokrpur S, Pietryga IF, Molinolo AA, Mesirov JP, Simon AB, Fox BA, Bui JD, Sharabi A, Cohen EEW, Califano JA, Gutkind JS. PMID: 35879302; PMCID: PMC9314425.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    20. Microneedle-mediated Intratumoral Delivery of Anti-CTLA-4 Promotes cDC1-dependent Eradication of Oral Squamous Cell Carcinoma with Limited irAEs. Mol Cancer Ther. 2022 04 01; 21(4):616-624. Gilardi M, Saddawi-Konefka R, Wu VH, Lopez-Ramirez MA, Wang Z, Soto F, Ramms DJ, Proietto M, Mikulski Z, Miki H, Sharabi A, Kupor D, Rueda R, Hollern DP, Wang J, Gutkind JS. PMID: 35086958; PMCID: PMC8983493.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    21. Defining the Role of Immunotherapy in the Curative Treatment of Locoregionally Advanced Head and Neck Cancer: Promises, Challenges, and Opportunities. Front Oncol. 2021; 11:738626. Saddawi-Konefka R, Simon AB, Sumner W, Sharabi A, Mell LK, Cohen EEW. PMID: 34621678; PMCID: PMC8490924.
      View in: PubMed   Mentions: 9  
    22. Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma. Clin Cancer Res. 2021 Aug 15; 27(16):4664. Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Lubrano S, Gomes F, Arang N, Tiago M, Coma S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS. PMID: 34389658.
      View in: PubMed   Mentions: 1     Fields:    
    23. Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer. Nat Commun. 2021 04 22; 12(1):2383. Wang Z, Goto Y, Allevato MM, Wu VH, Saddawi-Konefka R, Gilardi M, Alvarado D, Yung BS, O'Farrell A, Molinolo AA, Duvvuri U, Grandis JR, Califano JA, Cohen EEW, Gutkind JS. PMID: 33888713; PMCID: PMC8062674.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    24. Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma. Clin Cancer Res. 2021 06 01; 27(11):3190-3200. Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Gomes F, Arang N, Tiago M, Coma S, Lubrano S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS. PMID: 33568347; PMCID: PMC8895627.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    25. Immunotherapy in sinonasal melanoma: treatment patterns and outcomes compared to cutaneous melanoma. Int Forum Allergy Rhinol. 2020 09; 10(9):1087-1095. Klebaner D, Saddawi-Konefka R, Finegersh A, Yan CH, Califano JA, London NR, Deconde AS, Faraji F. PMID: 32623838.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    26. Meta-analysis of risk of occult lymph node metastasis in the irradiated, clinically N0 neck. Head Neck. 2020 09; 42(9):2355-2363. Finegersh A, Moss WJ, Saddawi-Konefka R, Faraji F, Coffey CS, Califano JA, Brumund KT, Orosco RK. PMID: 32432819.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. The role of 3D printing in pediatric airway obstruction: A systematic review. Int J Pediatr Otorhinolaryngol. 2020 May; 132:109923. Stramiello JA, Saddawi-Konefka R, Ryan J, Brigger MT. PMID: 32035351.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    28. Transient Abducens Nerve Palsy After Sphenopalatine Block Following Endoscopic Sinus Surgery. JAMA Otolaryngol Head Neck Surg. 2019 Sep 01; 145(9):871-873. Saddawi-Konefka R, Jafari A, Bracken D, Deconde A. PMID: 31343691.
      View in: PubMed   Mentions: 1     Fields:    
    29. Nonsurgical Treatment of Keloids and Hypertrophic Scars. Facial Plast Surg. 2019 Jun; 35(3):260-266. Saddawi-Konefka R, Watson D. PMID: 31189199.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Perioperative Risk Factors Associated With Morbidity and Mortality Following Pediatric Inpatient Sinus Surgery. Ann Otol Rhinol Laryngol. 2019 Jan; 128(1):13-21. Burton BN, Gilani S, Desai M, Saddawi-Konefka R, Willies-Jacobo L, Gabriel RA. PMID: 30328698.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. A Lot to Choke on: Case of Adult Epiglottitis with Concurrent Peritonsillar Abscess in a Patient with a Sore Throat. J Emerg Med. 2018 Dec; 55(6):841-844. Parthasarathy V, Snyder B, Saddawi-Konefka R. PMID: 30342860.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection. Sci Rep. 2018 09 12; 8(1):13670. Seelige R, Saddawi-Konefka R, Adams NM, Picarda G, Sun JC, Benedict CA, Bui JD. PMID: 30209334; PMCID: PMC6135835.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    33. Inverted schneiderian papilloma of the supraglottis: Case report. Laryngoscope. 2017 12; 127(12):2830-2832. Saddawi-Konefka R, Hariri N, Shabaik A, Weissbrod PA. PMID: 28699194.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance. Cell Rep. 2016 08 30; 16(9):2348-58. Saddawi-Konefka R, Seelige R, Gross ET, Levy E, Searles SC, Washington A, Santosa EK, Liu B, O'Sullivan TE, Harismendy O, Bui JD. PMID: 27545889; PMCID: PMC5007173.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    35. Tumor-expressed IL-17D recruits NK cells to reject tumors. Oncoimmunology. 2014 Dec; 3(12):e954853. Saddawi-Konefka R, O'Sullivan T, Gross ET, Washington A, Bui JD. PMID: 25964859; PMCID: PMC4353093.
      View in: PubMed   Mentions: 18     Fields:    
    36. Interleukin-17D mediates tumor rejection through recruitment of natural killer cells. Cell Rep. 2014 May 22; 7(4):989-98. O'Sullivan T, Saddawi-Konefka R, Gross E, Tran M, Mayfield SP, Ikeda H, Bui JD. PMID: 24794441; PMCID: PMC4084720.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    37. Cancer immunoediting by the innate immune system in the absence of adaptive immunity. J Exp Med. 2012 Sep 24; 209(10):1869-82. O'Sullivan T, Saddawi-Konefka R, Vermi W, Koebel CM, Arthur C, White JM, Uppaluri R, Andrews DM, Ngiow SF, Teng MW, Smyth MJ, Schreiber RD, Bui JD. PMID: 22927549; PMCID: PMC3457735.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    38. Chronic viral infection and primary central nervous system malignancy. J Neuroimmune Pharmacol. 2010 Sep; 5(3):387-403. Saddawi-Konefka R, Crawford JR. PMID: 20387126; PMCID: PMC2914282.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
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