Gregory Botta

Title(s)Assistant Clinical Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Carnegie Mellon University, PittsburghBS05/2004Information Systems & Biomedical Engineering
    University of Pittsburgh, Pittsburgh04/2006Biomedical Engineering
    Drexel University, PhiladelphiaPhD01/2012Molecular & Cellular Biology and Genetics
    University of Pennsylvania, PhiladelphiaPost-Doctoral05/2014Cancer Biology and Stem Cells
    Drexel University College of Medicine, PhiladelphiaMD05/2014Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    iRGD Reprogramming of Metabolically Suppressed Pancreatic Cancer
    NCI LRP KYGF9753Nov 1, 2018 - Nov 1, 2020
    Role: Principal Investigator
    Institutional Career Development Core
    NIH KL2TR002552May 1, 2018 - Apr 30, 2023
    Role: Co-Investigator
    Scripps Translational Science Institute
    NIH KL2TR001112Sep 26, 2013 - Apr 30, 2018
    Role: Co-Investigator
    Induced Reactive Oxygen Species in a 3-D Human Pancreatitis Model in Vitro
    NIH F30DK088402Jul 1, 2010 - Jun 30, 2014
    Role: Principal Investigator
    Scripps Translational Science Institute (KL2)
    NIH KL2TR000110May 19, 2008 - Oct 31, 2013
    Role: Co-Investigator
    Scripps Translational Science Institute (KL2)
    NIH KL2RR025773May 19, 2008 - Apr 30, 2013
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy. Mol Cancer Ther. 2021 12; 20(12):2341-2351. Mardinian K, Adashek JJ, Botta GP, Kato S, Kurzrock R. PMID: 34642211; PMCID: PMC8643328.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer. JCI Insight. 2021 09 22; 6(18). Botta GP, Kato S, Patel H, Fanta P, Lee S, Okamura R, Kurzrock R. PMID: 34375311; PMCID: PMC8492298.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. Tri-modal management of primary small cell carcinoma of the pancreas (SCCP): a rare neuroendocrine carcinoma (NEC). BMC Gastroenterol. 2021 Sep 03; 21(1):340. Elzein S, Bao F, Lin R, Schnickel G, Lowy AM, Botta GP. PMID: 34479480; PMCID: PMC8414857.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Tumor-penetrating therapy for β5 integrin-rich pancreas cancer. Nat Commun. 2021 03 09; 12(1):1541. Hurtado de Mendoza T, Mose ES, Botta GP, Braun GB, Kotamraju VR, French RP, Suzuki K, Miyamura N, Teesalu T, Ruoslahti E, Lowy AM, Sugahara KN. PMID: 33750829; PMCID: PMC7943581.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. Hemorrhagic Cystitis: Treatment With Hyperbaric Oxygen Therapy in Patients With Acute Lymphoblastic Leukemia. Clin J Oncol Nurs. 2018 12 01; 22(6):E146-E151. Botta LM, Botta GP. PMID: 30451996.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome. Mol Clin Oncol. 2018 04; 8(4):609-612. Bhangoo MS, Cheng B, Botta GP, Thorson P, Kosty MP. PMID: 29541472; PMCID: PMC5838296.
      View in: PubMed   Mentions: 6  
    7. Advances on immunotherapy in genitourinary and renal cell carcinoma. Transl Cancer Res. 2017 Feb; 6(1):17-29. Botta GP, Granowicz E, Costantini C. PMID: 28966917; PMCID: PMC5617347.
      View in: PubMed   Mentions: 6  
    8. Spontaneous Iliopsoas Muscle Hemorrhage Secondary to Ibrutinib (Imbruvica; Pharmacyclics): Brief Report. J Investig Med High Impact Case Rep. 2016 Apr-Jun; 4(2):2324709616648457. Sarcon A, Botta GP, Patel N, Saven A. PMID: 27231694; PMCID: PMC4871198.
      View in: PubMed   Mentions:    Fields:    
    9. Isolation, culture and genetic manipulation of mouse pancreatic ductal cells. Nat Protoc. 2013; 8(7):1354-65. Reichert M, Takano S, Heeg S, Bakir B, Botta GP, Rustgi AK. PMID: 23787893; PMCID: PMC4121532.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    10. ERK2-regulated TIMP1 induces hyperproliferation of K-Ras(G12D)-transformed pancreatic ductal cells. Neoplasia. 2013 Apr; 15(4):359-72. Botta GP, Reichert M, Reginato MJ, Heeg S, Rustgi AK, Lelkes PI. PMID: 23555182; PMCID: PMC3612909.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. Electrospun hydroxyapatite-containing chitosan nanofibers crosslinked with genipin for bone tissue engineering. Biomaterials. 2012 Dec; 33(36):9167-78. Frohbergh ME, Katsman A, Botta GP, Lazarovici P, Schauer CL, Wegst UG, Lelkes PI. PMID: 23022346; PMCID: PMC3488354.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    12. Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1. Mol Cancer Res. 2012 Feb; 10(2):183-96. Botta GP, Reginato MJ, Reichert M, Rustgi AK, Lelkes PI. PMID: 22160930; PMCID: PMC3288768.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    13. Sex of muscle stem cells does not influence potency for cardiac cell therapy. Cell Transplant. 2009; 18(10):1137-46. Drowley L, Okada M, Payne TR, Botta GP, Oshima H, Keller BB, Tobita K, Huard J. PMID: 19523348.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    14. Real-time assessment of three-dimensional cell aggregation in rotating wall vessel bioreactors in vitro. Nat Protoc. 2006; 1(4):2116-27. Botta GP, Manley P, Miller S, Lelkes PI. PMID: 17487203.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells