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Liu, Lin

Title(s)Assistant Adjunct Professor, Family Medicine and Public Health
SchoolHealth Sciences
Phone858-822-5877
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    Dr. Liu’s statistical methodology research includes three areas a) developing efficient methodologies in detecting the difference between dose-response means especially to identify minimum effective dose in dose-response and toxicity studies, b) developing new research methodology and statistical software in analysis of longitudinal HIV viral load data, and c) developing prognostic models in colorectal cancer research. As a collaborative biostatistician, Dr. Liu has worked in the area of cancer, cardiovascular disease, hepatitis C, chronic pain, HIV, infectious disease epidemiology, drug and alcohol abuse, sleep apnea, posttraumatic stress disorder (PTSD), Parkinson’s disease, traumatic brain injury (TBI), psychiatric disorder, telemedicine etc.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, Liu L, Corr M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N. PTPN14 phosphatase and YAP promote TGFß signalling in rheumatoid synoviocytes. Ann Rheum Dis. 2019 May; 78(5):600-609. PMID: 30808624.
      View in: PubMed
    2. Bustamante R, Earles A, Murphy JD, Bryant AK, Patterson OV, Gawron AJ, Kaltenbach T, Whooley MA, Fisher DA, Saini SD, Gupta S, Liu L. Ascertainment of Aspirin Exposure Using Structured and Unstructured Large-scale Electronic Health Record Data. Med Care. 2019 Feb 21. PMID: 30807451.
      View in: PubMed
    3. Do D, Garfein RS, Cuevas-Mota J, Collins K, Liu L. Change in Patient Comfort Using Mobile Phones Following the Use of an App to Monitor Tuberculosis Treatment Adherence: Longitudinal Study. JMIR Mhealth Uhealth. 2019 Feb 01; 7(2):e11638. PMID: 30707103.
      View in: PubMed
    4. Earles A, Liu L, Bustamante R, Coke P, Lynch J, Messer K, Martínez ME, Murphy JD, Williams CD, Fisher DA, Provenzale DT, Gawron AJ, Kaltenbach T, Gupta S. Structured Approach for Evaluating Strategies for Cancer Ascertainment Using Large-Scale Electronic Health Record Data. JCO Clin Cancer Inform. 2018 12; 2:1-12. PMID: 30652546.
      View in: PubMed
    5. Garfein RS, Liu L, Cuevas-Mota J, Collins K, Muñoz F, Catanzaro DG, Moser K, Higashi J, Al-Samarrai T, Kriner P, Vaishampayan J, Cepeda J, Bulterys MA, Martin NK, Rios P, Raab F. Tuberculosis Treatment Monitoring by Video Directly Observed Therapy in 5 Health Districts, California, USA. Emerg Infect Dis. 2018 10; 24(10):1806-1815. PMID: 30226154.
      View in: PubMed
    6. Lopez FV, Split M, Filoteo JV, Litvan I, Moore RC, Pirogovsky-Turk E, Liu L, Lessig S, Schiehser DM. Does the Geriatric Depression Scale measure depression in Parkinson's disease? Int J Geriatr Psychiatry. 2018 12; 33(12):1662-1670. PMID: 30251374.
      View in: PubMed
    7. Gupta S, Liu L, Patterson OV, Earles A, Bustamante R, Gawron AJ, Thompson WK, Scuba W, Denhalter D, Martinez ME, Messer K, Fisher DA, Saini SD, DuVall SL, Chapman WW, Whooley MA, Kaltenbach T. A Framework for Leveraging "Big Data" to Advance Epidemiology and Improve Quality: Design of the VA Colonoscopy Collaborative. EGEMS (Wash DC). 2018 Apr 13; 6(1):4. PMID: 29881762.
      View in: PubMed
    8. Deering S, Liu L, Zamora T, Hamilton J, Stepnowsky C. CPAP Adherence is Associated With Attentional Improvements in a Group of Primarily Male Patients With Moderate to Severe OSA. J Clin Sleep Med. 2017 Dec 15; 13(12):1423-1428. PMID: 29065955.
      View in: PubMed
    9. Street RL, Liu L, Farber NJ, Chen Y, Calvitti A, Weibel N, Gabuzda MT, Bell K, Gray B, Rick S, Ashfaq S, Agha Z. Keystrokes, Mouse Clicks, and Gazing at the Computer: How Physician Interaction with the EHR Affects Patient Participation. J Gen Intern Med. 2018 Apr; 33(4):423-428. PMID: 29188544.
      View in: PubMed
    10. Groessl EJ, Liu L, Sklar M, Ho SB. HCV Integrated Care: A Randomized Trial to Increase Treatment Initiation and SVR with Direct Acting Antivirals. Int J Hepatol. 2017; 2017:5834182. PMID: 28819570.
      View in: PubMed
    11. Groessl EJ, Liu L, Chang DG, Wetherell JL, Bormann JE, Atkinson JH, Baxi S, Schmalzl L. Yoga for Military Veterans with Chronic Low Back Pain: A Randomized Clinical Trial. Am J Prev Med. 2017 Nov; 53(5):599-608. PMID: 28735778.
      View in: PubMed
    12. Dever JB, Ducom JH, Ma A, Nguyen J, Liu L, Herrin A, Groessl EJ, Ho SB. Engagement in Care of High-Risk Hepatitis C Patients with Interferon-Free Direct-Acting Antiviral Therapies. Dig Dis Sci. 2017 06; 62(6):1472-1479. PMID: 28378246.
      View in: PubMed
    13. Beck D, Cosco Holt L, Burkard J, Andrews T, Liu L, Heppner P, Bormann JE. Efficacy of the Mantram Repetition Program for Insomnia in Veterans With Posttraumatic Stress Disorder: A Naturalistic Study. ANS Adv Nurs Sci. 2017 Apr/Jun; 40(2):E1-E12. PMID: 27525960.
      View in: PubMed
    14. Calvitti A, Hochheiser H, Ashfaq S, Bell K, Chen Y, El Kareh R, Gabuzda MT, Liu L, Mortensen S, Pandey B, Rick S, Street RL, Weibel N, Weir C, Agha Z. Physician activity during outpatient visits and subjective workload. J Biomed Inform. 2017 05; 69:135-149. PMID: 28323114.
      View in: PubMed
    15. Akram A, Juang D, Bustamante R, Liu L, Earles A, Ho SB, Wang-Rodriguez J, Allison JE, Gupta S. Replacing the Guaiac Fecal Occult Blood Test With the Fecal Immunochemical Test Increases Proportion of Individuals Screened in a Large Healthcare Setting. Clin Gastroenterol Hepatol. 2017 Aug; 15(8):1265-1270.e1. PMID: 28167157.
      View in: PubMed
    16. Pines HA, Wertheim JO, Liu L, Garfein RS, Little SJ, Karris MY. Concurrency and HIV transmission network characteristics among MSM with recent HIV infection. AIDS. 2016 11 28; 30(18):2875-2883. PMID: 27662550.
      View in: PubMed
    17. Herbert MS, Afari N, Liu L, Heppner P, Rutledge T, Williams K, Eraly S, VanBuskirk K, Nguyen C, Bondi M, Atkinson JH, Golshan S, Wetherell JL. Telehealth Versus In-Person Acceptance and Commitment Therapy for Chronic Pain: A Randomized Noninferiority Trial. J Pain. 2017 02; 18(2):200-211. PMID: 27838498.
      View in: PubMed
    18. Liu L, Messer K, Baron JA, Lieberman DA, Jacobs ET, Cross AJ, Murphy G, Martinez ME, Gupta S. A prognostic model for advanced colorectal neoplasia recurrence. Cancer Causes Control. 2016 10; 27(10):1175-85. PMID: 27517467.
      View in: PubMed
    19. Groessl EJ, Schmalzl L, Maiya M, Liu L, Goodman D, Chang DG, Wetherell JL, Bormann JE, Atkinson JH, Baxi S. Yoga for veterans with chronic low back pain: Design and methods of a randomized clinical trial. Contemp Clin Trials. 2016 05; 48:110-8. PMID: 27103548.
      View in: PubMed
    20. Hu WH, Chen HH, Lee KC, Liu L, Eisenstein S, Parry L, Cosman B, Ramamoorthy S. Assessment of the Addition of Hypoalbuminemia to ACS-NSQIP Surgical Risk Calculator in Colorectal Cancer. Medicine (Baltimore). 2016 Mar; 95(10):e2999. PMID: 26962812; PMCID: PMC4998893.
    21. Gupta S, Jacobs ET, Baron JA, Lieberman DA, Murphy G, Ladabaum U, Cross AJ, Jover R, Liu L, Martinez ME. Risk stratification of individuals with low-risk colorectal adenomas using clinical characteristics: a pooled analysis. Gut. 2017 03; 66(3):446-453. PMID: 26658145.
      View in: PubMed
    22. Zhang J, Chen Y, Ashfaq S, Bell K, Calvitti A, Farber NJ, Gabuzda MT, Gray B, Liu L, Rick S, Street RL, Zheng K, Zuest D, Agha Z. Strategizing EHR use to achieve patient-centered care in exam rooms: a qualitative study on primary care providers. J Am Med Inform Assoc. 2016 Jan; 23(1):137-43. PMID: 26568605; PMCID: PMC5009938 [Available on 01/01/17].
    23. Farber NJ, Liu L, Chen Y, Calvitti A, Street RL, Zuest D, Bell K, Gabuzda M, Gray B, Ashfaq S, Agha Z. EHR use and patient satisfaction: What we learned. J Fam Pract. 2015 Nov; 64(11):687-96. PMID: 26697540.
      View in: PubMed
    24. Schiehser DM, Twamley EW, Liu L, Matevosyan A, Filoteo JV, Jak AJ, Orff HJ, Hanson KL, Sorg SF, Delano-Wood L. The Relationship Between Postconcussive Symptoms and Quality of Life in Veterans With Mild to Moderate Traumatic Brain Injury. J Head Trauma Rehabil. 2015 Jul-Aug; 30(4):E21-8. PMID: 24922041.
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    25. Wagner KD, Liu L, Davidson PJ, Cuevas-Mota J, Armenta RF, Garfein RS. Association between non-fatal opioid overdose and encounters with healthcare and criminal justice systems: Identifying opportunities for intervention. Drug Alcohol Depend. 2015 Aug 01; 153:215-20. PMID: 26091751; PMCID: PMC4512661.
    26. Ho SB, Bräu N, Cheung R, Liu L, Sanchez C, Sklar M, Phelps TE, Marcus SG, Wasil MM, Tisi A, Huynh L, Robinson SK, Gifford AL, Asch SM, Groessl EJ. Integrated Care Increases Treatment and Improves Outcomes of Patients With Chronic Hepatitis C Virus Infection and Psychiatric Illness or Substance Abuse. Clin Gastroenterol Hepatol. 2015 Nov; 13(11):2005-14.e1-3. PMID: 25724704.
      View in: PubMed
    27. Street RL, Liu L, Farber NJ, Chen Y, Calvitti A, Zuest D, Gabuzda MT, Bell K, Gray B, Rick S, Ashfaq S, Agha Z. Provider interaction with the electronic health record: the effects on patient-centered communication in medical encounters. Patient Educ Couns. 2014 Sep; 96(3):315-9. PMID: 24882086; PMCID: PMC4339111.
    28. Pirogovsky E, Schiehser DM, Litvan I, Obtera KM, Burke MM, Lessig SL, Song DD, Liu L, Filoteo JV. The utility of the Mattis Dementia Rating Scale in Parkinson's disease mild cognitive impairment. Parkinsonism Relat Disord. 2014 Jun; 20(6):627-31. PMID: 24709086.
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    29. Liu L, Lee CIC and Peng J.Simultaneous Confidence Bounds in Monotone Dose-Response Studies. Journal of Statistical Planning and Inference. 2014; (145):113-124.
    30. Riley DE, Liu L, Cohen B, Robinson S, Groessl EJ, Ho SB. Characteristics and impact of methamphetamine use in patients with chronic hepatitis C. J Addict Med. 2014 Jan-Feb; 8(1):25-32. PMID: 24343127; PMCID: PMC4339184.
    31. Stepnowsky C, Zamora T, Barker R, Liu L, Sarmiento K. Accuracy of positive airway pressure device-measured apneas and hypopneas: role in treatment followup. Sleep Disord. 2013; 2013:314589. PMID: 24062954; PMCID: PMC3767059.
    32. Schiehser DM, Liu L, Lessig SL, Song DD, Obtera KM, Burke Iii MM, Earl SR, Vincent Filoteo J. Predictors of discrepancies in Parkinson's disease patient and caregiver ratings of apathy, disinhibition, and executive dysfunction before and after diagnosis. J Int Neuropsychol Soc. 2013 Mar; 19(3):295-304. PMID: 23351239.
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    33. Schiehser DM, Ayers CR, Liu L, Lessig S, Song DS, Filoteo JV. Validation of the Modified Fatigue Impact Scale in Parkinson's disease. Parkinsonism Relat Disord. 2013 Mar; 19(3):335-8. PMID: 23246138.
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    34. Bormann JE, Liu L, Thorp SR, Lang AJ. Spiritual wellbeing mediates PTSD change in veterans with military-related PTSD. Int J Behav Med. 2012 Dec; 19(4):496-502. PMID: 21874605.
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    35. Groessl EJ, Liu L, Sklar M, Tally SR, Kaplan RM, Ganiats TG. Measuring the impact of cataract surgery on generic and vision-specific quality of life. Qual Life Res. 2013 Aug; 22(6):1405-14. PMID: 23015266; PMCID: PMC3578053.
    36. Bhatnagar V, Liu L, Nievergelt CM, Richard E, Brophy VH, Pandey B, Lipkowitz MS, O'Connor DT. Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure. Am J Hypertens. 2012 Nov; 25(11):1188-94. PMID: 22854640; PMCID: PMC3515680.
    37. Lindamer LA, Liu L, Sommerfeld DH, Folsom DP, Hawthorne W, Garcia P, Aarons GA, Jeste DV. Predisposing, enabling, and need factors associated with high service use in a public mental health system. Adm Policy Ment Health. 2012 May; 39(3):200-9. PMID: 21533848; PMCID: PMC3288205.
    38. Groessl EJ, Liu L, Ho SB, Kanwal F, Gifford AL, Asch SM. National patterns and predictors of liver biopsy use for management of hepatitis C. J Hepatol. 2012 Aug; 57(2):252-9. PMID: 22521358.
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    39. Petkus AJ, Wetherell JL, Stein MB, Liu L, Barrett-Connor E. History of sexual assault is associated with greater declines in executive functioning in older adults with APOE epsilon4. J Gerontol B Psychol Sci Soc Sci. 2012 Nov; 67(6):653-9. PMID: 22357643; PMCID: PMC3478726.
    40. Ghanem A, Little SJ, Drumright L, Liu L, Morris S, Garfein RS. High-risk behaviors associated with injection drug use among recently HIV-infected men who have sex with men in San Diego, CA. AIDS Behav. 2011 Oct; 15(7):1561-9. PMID: 21607643.
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    41. Wetherell JL, Afari N, Rutledge T, Sorrell JT, Stoddard JA, Petkus AJ, Solomon BC, Lehman DH, Liu L, Lang AJ, Atkinson JH. A randomized, controlled trial of acceptance and commitment therapy and cognitive-behavioral therapy for chronic pain. Pain. 2011 Sep; 152(9):2098-107. PMID: 21683527.
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    42. Lee J, Aziz H, Liu L, Lipkowitz M, O'Connor DT, Richard E, Brophy V, Wassel CL, Blantz R, Bhatnagar V. ß(1)-adrenergic receptor polymorphisms and response to ß-blockade in the African-American study of kidney disease and hypertension (AASK). Am J Hypertens. 2011 Jun; 24(6):694-700. PMID: 21415838.
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    43. Guluma KZ, Liu L, Hemmen TM, Acharya AB, Rapp KS, Raman R, Lyden PD. Therapeutic hypothermia is associated with a decrease in urine output in acute stroke patients. Resuscitation. 2010 Dec; 81(12):1642-7. PMID: 20817376; PMCID: PMC2991385.
    44. Wetherell JL, Afari N, Ayers CR, Stoddard JA, Ruberg J, Sorrell JT, Liu L, Petkus AJ, Thorp SR, Kraft A, Patterson TL. Acceptance and Commitment Therapy for generalized anxiety disorder in older adults: a preliminary report. Behav Ther. 2011 Mar; 42(1):127-34. PMID: 21292059; PMCID: PMC3496779.
    45. Cheung RT, Lyden PD, Tsoi TH, Huang Y, Liu M, Hon SF, Raman R, Liu L. Production and validation of Putonghua- and Cantonese-Chinese language National Institutes of Health Stroke Scale training and certification videos. Int J Stroke. 2010 Apr; 5(2):74-9. PMID: 20446940.
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    46. Lyden P, Raman R, Liu L, Emr M, Warren M, Marler J. National Institutes of Health Stroke Scale certification is reliable across multiple venues. Stroke. 2009 Jul; 40(7):2507-11. PMID: 19520998; PMCID: PMC2726278.
    47. Garfein RS, Lozada R, Liu L, Laniado-Laborin R, Rodwell TC, Deiss R, Alvelais J, Catanzaro A, Chiles PG, Strathdee SA. High prevalence of latent tuberculosis infection among injection drug users in Tijuana, Mexico. Int J Tuberc Lung Dis. 2009 May; 13(5):626-32. PMID: 19383197; PMCID: PMC2744313.
    48. Vaida F and Liu L.Fast Implementation for Normal Mixed Effects Models with Censored Response. Journal of Computational and Graphical Statistics. 2009; 4(18):797-817.
    49. Liu L, May S, Richman DD, Hecht FM, Markowitz M, Daar ES, Routy JP, Margolick JB, Collier AC, Woelk CH, Little SJ, Smith DM. Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance. AIDS. 2008 Apr 23; 22(7):835-9. PMID: 18427201.
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    50. Koelsch KK, Liu L, Haubrich R, May S, Havlir D, Günthard HF, Ignacio CC, Campos-Soto P, Little SJ, Shafer R, Robbins GK, D'Aquila RT, Kawano Y, Young K, Dao P, Spina CA, Richman DD, Wong JK. Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro. J Infect Dis. 2008 Feb 01; 197(3):411-9. PMID: 18248304.
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    51. Bashey A, Donohue M, Liu L, Medina B, Corringham S, Ihasz A, Carrier E, Castro JE, Holman PR, Xu R, Law P, Ball ED, Lane TA. Peripheral blood progenitor cell mobilization with intermediate-dose cyclophosphamide, sequential granulocyte-macrophage-colony-stimulating factor and granulocyte-colony-stimulating factor, and scheduled commencement of leukapheresis in 225 patients undergoing autologous transplantation. Transfusion. 2007 Nov; 47(11):2153-60. PMID: 17958545.
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    52. Goicoechea M, Smith DM, Liu L, May S, Tenorio AR, Ignacio CC, Landay A, Haubrich R. Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: association of immune activation, T cell maturation markers, and cellular HIV-1 DNA. J Infect Dis. 2006 Jul 01; 194(1):29-37. PMID: 16741879.
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    53. Lee CC, Peng J and Liu L .Statistical Inference for the Difference between the Best Treatment Mean and a Control Mean. Journal of the American Statistical Association. 2006; (101):1050-1058.
    54. Bashey A, Liu L, Ihasz A, Medina B, Corringham S, Keese K, Carrier E, Castro JE, Holman P, Lane TA, Hassidim K, Ball ED. Non-anthracycline based remission induction therapy for newly diagnosed patients with acute myeloid leukemia aged 60 or older. Leuk Res. 2006 Apr; 30(4):503-6. PMID: 16303178.
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    55. Lyden P, Raman R, Liu L, Grotta J, Broderick J, Olson S, Shaw S, Spilker J, Meyer B, Emr M, Warren M, Marler J. NIHSS training and certification using a new digital video disk is reliable. Stroke. 2005 Nov; 36(11):2446-9. PMID: 16224093.
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    56. Liu L, Lee CC and Peng J.Max-min Multiple Comparison Procedure for MonotoneDose-Response Curves. Journal of Statistical Planning and Inference. 2002; (107):133-141.