Matthew Hangauer

Title(s)	Assistant Professor, Dermatology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

UC Berkeley	Ph.D.	2009	Chemistry
Vanderbilt University	B.S.	2003	Chemistry

Overview

The Hangauer lab explores the biology of cancer persister cells, a prevalent yet poorly understood subpopulation of cancer cells that reversibly enter into a quiescent, pro-survival cell state to survive drug treatments. We seek to discover persister cell gene vulnerabilities, explore their biological mechanisms, and translate our findings into novel therapeutic approaches.

Websites

	Hangauer Lab Site
	Dermatology Faculty Site

In The News

	The Ferrous Awakens (11/30/2017)
	Diverse Drug-Resistant Cancer Cells Share a Hidden Weakness (11/03/2017)
	DNA Found Outside Genes Plays Largely Unknown, Potentially Vital Roles (06/27/2013)

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities. Nat Rev Cancer. 2024 Oct; 24(10):694-717. Russo M, Chen M, Mariella E, Peng H, Rehman SK, Sancho E, Sogari A, Toh TS, Balaban NQ, Batlle E, Bernards R, Garnett MJ, Hangauer M, Leucci E, Marine JC, O'Brien CA, Oren Y, Patton EE, Robert C, Rosenberg SM, Shen S, Bardelli A. PMID: 39223250.

View in: PubMed Mentions: Fields:
Neo Neoplasms
Pan-RAF:MEK Molecular Glues Take Center Stage. Cancer Discov. 2024 Jul 01; 14(7):1143-1144. Hangauer MJ, Gutkind JS, Ferguson FM. PMID: 38946324.

View in: PubMed Mentions: Fields:
Neo Neoplasms
Translation:Humans Animals Cells
An expanded universe of cancer targets. Cell. 2021 03 04; 184(5):1142-1155. Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS, Cancer Target Discovery and Development Network. PMID: 33667368; PMCID: PMC8066437.

View in: PubMed Mentions: 79 Fields:
Cel Cell Biology
Translation:Humans Animals
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep. 2019 04 09; 27(2):631-647.e5. Mues M, Karra L, Romero-Moya D, Wandler A, Hangauer MJ, Ksionda O, Thus Y, Lindenbergh M, Shannon K, McManus MT, Roose JP. PMID: 30970263; PMCID: PMC6690758.

View in: PubMed Mentions: 5 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. 2017 11 09; 551(7679):247-250. Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT. PMID: 29088702; PMCID: PMC5933935.

View in: PubMed Mentions: 667 Fields:
Sci Science
Translation:Humans Animals
Transforming Big Data into Cancer-Relevant Insight: An Initial, Multi-Tier Approach to Assess Reproducibility and Relevance. Mol Cancer Res. 2016 08; 14(8):675-82. Cancer Target Discovery and Development Network. PMID: 27401613; PMCID: PMC4987219.

View in: PubMed Mentions: 5 Fields:
Cel Cell Biology Mol Molecular Biology Neo Neoplasms
Translation:Humans
Drug Resistance to EGFR Inhibitors in Lung Cancer. Chemotherapy. 2016; 61(5):223-35. Tetsu O, Hangauer MJ, Phuchareon J, Eisele DW, McCormick F. PMID: 26910730; PMCID: PMC4844777.

View in: PubMed Mentions: 34 Fields:
Dru Drug Therapy
Translation:Humans
AKT inactivation causes persistent drug tolerance to EGFR inhibitors. Pharmacol Res. 2015 Dec; 102:132-7. Tetsu O, Phuchareon J, Eisele DW, Hangauer MJ, McCormick F. PMID: 26453958.

View in: PubMed Mentions: 18 Fields:
Pha Pharmacology
Translation:Humans
Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30. Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. PMID: 25693563; PMCID: PMC4530010.

View in: PubMed Mentions: 3231 Fields:
Sci Science
Translation:Humans Cells
Epigenetic and transcriptional determinants of the human breast. Nat Commun. 2015 Feb 18; 6:6351. Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M. PMID: 25690954; PMCID: PMC4346612.

View in: PubMed Mentions: 38 Fields:
Bio Biology Sci Science
Translation:Humans Cells
Discovering the complexity of the metazoan transcriptome. Genome Biol. 2014 Apr 29; 15(4):112. Hangauer MJ, Carpenter S, McManus MT. PMID: 25001157; PMCID: PMC4054782.

View in: PubMed Mentions: 5 Fields:
Gen Genetics
Translation:Humans Animals Cells
A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2. Cell Rep. 2013 Oct 31; 5(2):546-52. Palaniappan KK, Hangauer MJ, Smith TJ, Smart BP, Pitcher AA, Cheng EH, Bertozzi CR, Boyce M. PMID: 24120863; PMCID: PMC3869705.

View in: PubMed Mentions: 22 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet. 2013 Jun; 9(6):e1003569. Hangauer MJ, Vaughn IW, McManus MT. PMID: 23818866; PMCID: PMC3688513.

View in: PubMed Mentions: 397 Fields:
Gen Genetics
Translation:Humans Cells
Fluorogenic azidofluoresceins for biological imaging. J Am Chem Soc. 2012 Oct 24; 134(42):17428-31. Shieh P, Hangauer MJ, Bertozzi CR. PMID: 23025473; PMCID: PMC3596100.

View in: PubMed Mentions: 34 Fields:
Che Chemistry
Translation:Animals Cells
Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome. Mol Endocrinol. 2012 Oct; 26(10):1783-92. Ku GM, Kim H, Vaughn IW, Hangauer MJ, Myung Oh C, German MS, McManus MT. PMID: 22915829; PMCID: PMC3458219.

View in: PubMed Mentions: 70 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3141-6. Boyce M, Carrico IS, Ganguli AS, Yu SH, Hangauer MJ, Hubbard SC, Kohler JJ, Bertozzi CR. PMID: 21300897; PMCID: PMC3044403.

View in: PubMed Mentions: 149 Fields:
Sci Science
Translation:Humans Cells
Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition. Chembiochem. 2010 Oct 18; 11(15):2092-5. Beatty KE, Fisk JD, Smart BP, Lu YY, Szychowski J, Hangauer MJ, Baskin JM, Bertozzi CR, Tirrell DA. PMID: 20836119; PMCID: PMC3069858.

View in: PubMed Mentions: 48 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. Biochemistry. 2009 Apr 14; 48(14):3068-77. Barb AW, Leavy TM, Robins LI, Guan Z, Six DA, Zhou P, Hangauer MJ, Bertozzi CR, Raetz CR. PMID: 19256534; PMCID: PMC2709817.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry
Translation:Cells
A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation. Angew Chem Int Ed Engl. 2008; 47(13):2394-7. Hangauer MJ, Bertozzi CR. PMID: 18306205; PMCID: PMC2446402.

View in: PubMed Mentions: 48 Fields:
Che Chemistry
Translation:Cells
Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J. 2008 Mar; 22(3):721-32. Kostiuk MA, Corvi MM, Keller BO, Plummer G, Prescher JA, Hangauer MJ, Bertozzi CR, Rajaiah G, Falck JR, Berthiaume LG. PMID: 17971398; PMCID: PMC2860959.

View in: PubMed Mentions: 67 Fields:
Bio Biology Phy Physiology
Translation:Humans Animals Cells
Imaging cell surface glycans with bioorthogonal chemical reporters. J Am Chem Soc. 2007 Jul 11; 129(27):8400-1. Chang PV, Prescher JA, Hangauer MJ, Bertozzi CR. PMID: 17579403; PMCID: PMC2535820.

View in: PubMed Mentions: 47 Fields:
Che Chemistry
Translation:Cells
Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics. Methods Enzymol. 2006; 415:230-50. Laughlin ST, Agard NJ, Baskin JM, Carrico IS, Chang PV, Ganguli AS, Hangauer MJ, Lo A, Prescher JA, Bertozzi CR. PMID: 17116478.

View in: PubMed Mentions: 61 Fields:
Bio Biochemistry
Translation:Animals Cells
Nonacid cleavable detergents applied to MALDI mass spectrometry profiling of whole cells. J Mass Spectrom. 2005 Oct; 40(10):1319-26. Norris JL, Hangauer MJ, Porter NA, Caprioli RM. PMID: 16220468.

View in: PubMed Mentions: 7 Fields:
Che Chemistry Techniques
Translation:Humans Cells
The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: hydroxyindole derivatives. Bioorg Med Chem Lett. 2000 Mar 06; 10(5):483-6. Milkiewicz KL, Marsilje TH, Woodworth RP, Bifulco N, Hangauer MJ, Hangauer DG. PMID: 10743953.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells