Roger Sunahara

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.University of Toronto

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Next-gen Opto-GPCRs: spatiotemporal simulation of neuormodulator signaling
    NIH R01MH111520Sep 9, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Structure-based discovery of allosteric ligands for G Protein Coupled Receptors
    NIH U19GM106990Sep 15, 2013 - May 31, 2018
    Role: Co-Investigator
    Crystallization and structure determination of the mu-opioid receptor
    NIH R21DA031418Jul 1, 2011 - Jun 30, 2013
    Role: Principal Investigator
    Structure and dynamics of G protein coupled receptor-G protein complexes
    NIH R01GM083118May 1, 2008 - Jun 30, 2024
    Role: Principal Investigator
    Structure and mechanism of beta2-adrenergic receptor
    NIH R01GM068603Aug 1, 2003 - Jul 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A photoswitchable GPCR-based opsin for presynaptic inhibition. Neuron. 2021 May 10. Copits BA, Gowrishankar R, O'Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, Shirley SE, Ma KKL, Vasquez AM, Stander MC, Kalyanaraman V, Vogt SK, Samineni VK, Patriarchi T, Tian L, Gautam N, Sunahara RK, Gereau RW, Bruchas MR. PMID: 33979635.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling. Cell. 2021 Apr 01; 184(7):1884-1894.e14. Huang SK, Pandey A, Tran DP, Villanueva NL, Kitao A, Sunahara RK, Sljoka A, Prosser RS. PMID: 33743210.
      View in: PubMed   Mentions: 3     Fields:    
    3. Binding pathway determines norepinephrine selectivity for the human ß1AR over ß2AR. Cell Res. 2021 May; 31(5):569-579. Xu X, Kaindl J, Clark MJ, Hübner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X. PMID: 33093660.
      View in: PubMed   Mentions: 3     Fields:    
    4. Structure and selectivity engineering of the M1 muscarinic receptor toxin complex. Science. 2020 07 10; 369(6500):161-167. Maeda S, Xu J, N Kadji FM, Clark MJ, Zhao J, Tsutsumi N, Aoki J, Sunahara RK, Inoue A, Garcia KC, Kobilka BK. PMID: 32646996.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Nature. 2020 08; 584(7819):125-129. Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM. PMID: 32528175.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    6. An allosteric modulator binds to a conformational hub in the ß2 adrenergic receptor. Nat Chem Biol. 2020 07; 16(7):749-755. Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P. PMID: 32483378.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. Structure of an endosomal signaling GPCR-G protein-ß-arrestin megacomplex. Nat Struct Mol Biol. 2019 12; 26(12):1123-1131. Nguyen AH, Thomsen ARB, Cahill TJ, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ. PMID: 31740855.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    8. Publisher Correction: Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist. Nat Chem Biol. 2019 02; 15(2):205. Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK. PMID: 30504785.
      View in: PubMed   Mentions:    Fields:    
    9. Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):12046-12050. Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, Liu X, Sunahara RK, Shoichet BK, Kobilka BK, Gmeiner P. PMID: 30404914.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    10. Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist. Nat Chem Biol. 2018 11; 14(11):1059-1066. Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK. PMID: 30327561.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    11. Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment. J Biol Chem. 2018 11 16; 293(46):17875-17887. Valnohova J, Kowalski-Jahn M, Sunahara RK, Schulte G. PMID: 30237173.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Rules of Engagement: GPCRs and G Proteins. ACS Pharmacol Transl Sci. 2018 Nov 09; 1(2):73-83. Glukhova A, Draper-Joyce CJ, Sunahara RK, Christopoulos A, Wootten D, Sexton PM. PMID: 32219204.
      View in: PubMed   Mentions:
    13. Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. Elife. 2018 06 22; 7. Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR. PMID: 29932421.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations. Nat Commun. 2018 04 10; 9(1):1372. Ye L, Neale C, Sljoka A, Lyda B, Pichugin D, Tsuchimura N, Larda ST, Pomès R, García AE, Ernst OP, Sunahara RK, Prosser RS. PMID: 29636462.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    15. Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2419-E2428. Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, Christopoulos A, Shoichet BK, Sunahara RK. PMID: 29453275.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    16. Structure-Based Design and Discovery of New M2 Receptor Agonists. J Med Chem. 2017 11 22; 60(22):9239-9250. Fish I, Stößel A, Eitel K, Valant C, Albold S, Huebner H, Möller D, Clark MJ, Sunahara RK, Christopoulos A, Shoichet BK, Gmeiner P. PMID: 29094937.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    17. ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells. Sci Rep. 2017 08 10; 7(1):7749. Malik RU, Dysthe M, Ritt M, Sunahara RK, Sivaramakrishnan S. PMID: 28798477.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    18. Genetic evidence that ß-arrestins are dispensable for the initiation of ß2-adrenergic receptor signaling to ERK. Sci Signal. 2017 Jun 20; 10(484). O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS. PMID: 28634209.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    19. Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor. PLoS One. 2017; 12(6):e0179568. Cai Y, Liu Y, Culhane KJ, DeVree BT, Yang Y, Sunahara RK, Yan ECY. PMID: 28609478.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes. J Am Chem Soc. 2017 03 15; 139(10):3607-3610. Brea RJ, Cole CM, Lyda BR, Ye L, Prosser RS, Sunahara RK, Devaraj NK. PMID: 28263576.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. Mechanistic insights into GPCR-G protein interactions. Curr Opin Struct Biol. 2016 12; 41:247-254. Mahoney JP, Sunahara RK. PMID: 27871057.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    22. GPCR-G Protein-ß-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell. 2016 Aug 11; 166(4):907-919. Thomsen ARB, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ. PMID: 27499021.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansCells
    23. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. 2016 07 07; 535(7610):182-6. DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. PMID: 27362234.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    24. The Molecular Pharmacology of G Protein Signaling Then and Now: A Tribute to Alfred G. Gilman. Mol Pharmacol. 2016 May; 89(5):585-92. Sunahara RK, Insel PA. PMID: 26984025.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Pharmacological chaperone for a-crystallin partially restores transparency in cataract models. Science. 2015 Nov 06; 350(6261):674-7. Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE. PMID: 26542570.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    26. Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami. ACS Nano. 2015 Jul 28; 9(7):7133-41. Mallik L, Dhakal S, Nichols J, Mahoney J, Dosey AM, Jiang S, Sunahara RK, Skiniotis G, Walter NG. PMID: 26149412.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    27. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science. 2015 Jun 19; 348(6241):1361-5. Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. PMID: 26089515.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    28. Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells. J Biol Chem. 2013 Jun 14; 288(24):17167-78. Malik RU, Ritt M, DeVree BT, Neubig RR, Sunahara RK, Sivaramakrishnan S. PMID: 23629648.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    29. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013 Mar 28; 495(7442):534-8. Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. PMID: 23515162.
      View in: PubMed   Mentions: 267     Fields:    Translation:HumansCells
    30. Calcium-dependent ligand binding and G-protein signaling of family B GPCR parathyroid hormone 1 receptor purified in nanodiscs. ACS Chem Biol. 2013 Mar 15; 8(3):617-25. Mitra N, Liu Y, Liu J, Serebryany E, Mooney V, DeVree BT, Sunahara RK, Yan EC. PMID: 23237450.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    31. Identification of GPCR-interacting cytosolic proteins using HDL particles and mass spectrometry-based proteomic approach. PLoS One. 2013; 8(1):e54942. Chung KY, Day PW, Vélez-Ruiz G, Sunahara RK, Kobilka BK. PMID: 23372797.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    32. Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys. J Pharmacol Exp Ther. 2012 Jul; 342(1):205-13. Collins GT, Brim RL, Noon KR, Narasimhan D, Lukacs NW, Sunahara RK, Woods JH, Ko MC. PMID: 22518021.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. Cell permeable cocaine esterases constructed by chemical conjugation and genetic recombination. Mol Pharm. 2012 May 07; 9(5):1361-73. Lee TY, Park YS, Garcia GA, Sunahara RK, Woods JH, Yang VC. PMID: 22404344.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012 Mar 21; 485(7398):321-6. Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. PMID: 22437502.
      View in: PubMed   Mentions: 465     Fields:    Translation:AnimalsCells
    35. Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction. Future Med Chem. 2012 Feb; 4(2):137-50. Narasimhan D, Woods JH, Sunahara RK. PMID: 22300094.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    36. Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats. Neuropsychopharmacology. 2012 Apr; 37(5):1092-103. Collins GT, Narasimhan D, Cunningham AR, Zaks ME, Nichols J, Ko MC, Sunahara RK, Woods JH. PMID: 21993206.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    37. The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination. J Pharmacol Exp Ther. 2012 Jan; 340(1):83-95. Brim RL, Noon KR, Collins GT, Stein A, Nichols J, Narasimhan D, Ko MC, Woods JH, Sunahara RK. PMID: 21990608.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    38. Conformational changes in the G protein Gs induced by the ß2 adrenergic receptor. Nature. 2011 Sep 28; 477(7366):611-5. Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL, Sunahara RK. PMID: 21956331.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    39. Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):16086-91. Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL, Steyaert J, Kobilka BK, Sunahara RK, Skiniotis G. PMID: 21914848.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    40. Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time. Mol Pharmacol. 2011 Dec; 80(6):1056-65. Narasimhan D, Collins GT, Nance MR, Nichols J, Edwald E, Chan J, Ko MC, Woods JH, Tesmer JJ, Sunahara RK. PMID: 21890748.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    41. The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry. Mol Pharmacol. 2011 Dec; 80(6):1119-27. Brim RL, Noon KR, Collins GT, Nichols J, Narasimhan D, Sunahara RK, Woods JH. PMID: 21885621.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    42. Crystal structure of the ß2 adrenergic receptor-Gs protein complex. Nature. 2011 Jul 19; 477(7366):549-55. Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK. PMID: 21772288.
      View in: PubMed   Mentions: 1100     Fields:    Translation:AnimalsCells
    43. Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs. Drug Alcohol Depend. 2011 Dec 15; 119(3):224-8. Brim RL, Noon KR, Nichols J, Narasimhan D, Woods JH, Sunahara RK. PMID: 21775073.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    44. Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats. Drug Alcohol Depend. 2011 Nov 01; 118(2-3):158-65. Collins GT, Zaks ME, Cunningham AR, St Clair C, Nichols J, Narasimhan D, Ko MC, Sunahara RK, Woods JH. PMID: 21481548.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    45. Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology. 2011 Apr; 36(5):1047-59. Collins GT, Carey KA, Narasimhan D, Nichols J, Berlin AA, Lukacs NW, Sunahara RK, Woods JH, Ko MC. PMID: 21289605.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    46. Structure of a nanobody-stabilized active state of the ß(2) adrenoceptor. Nature. 2011 Jan 13; 469(7329):175-80. Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK. PMID: 21228869.
      View in: PubMed   Mentions: 623     Fields:    Translation:HumansAnimalsCells
    47. Structure and function of an irreversible agonist-ß(2) adrenoceptor complex. Nature. 2011 Jan 13; 469(7329):236-40. Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK. PMID: 21228876.
      View in: PubMed   Mentions: 298     Fields:    Translation:HumansCells
    48. Reconstitution of G protein-coupled receptors into a model bilayer system: reconstituted high-density lipoprotein particles. Methods Mol Biol. 2011; 756:167-82. Vélez-Ruiz GA, Sunahara RK. PMID: 21870225.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    49. Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng Des Sel. 2010 Jul; 23(7):537-47. Narasimhan D, Nance MR, Gao D, Ko MC, Macdonald J, Tamburi P, Yoon D, Landry DM, Woods JH, Zhan CG, Tesmer JJ, Sunahara RK. PMID: 20436035.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    50. A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Mol Pharmacol. 2010 Apr; 77(4):593-600. Brim RL, Nance MR, Youngstrom DW, Narasimhan D, Zhan CG, Tesmer JJ, Sunahara RK, Woods JH. PMID: 20086035.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    51. PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity. J Control Release. 2010 Mar 03; 142(2):174-9. Park JB, Kwon YM, Lee TY, Brim R, Ko MC, Sunahara RK, Woods JH, Yang VC. PMID: 19857534.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    52. Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats. Drug Alcohol Depend. 2010 Jan 15; 106(2-3):219-29. Wood SK, Narasimhan D, Cooper Z, Sunahara RK, Woods JH. PMID: 19800183.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    53. Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. EMBO J. 2009 Nov 04; 28(21):3315-28. Fung JJ, Deupi X, Pardo L, Yao XJ, Velez-Ruiz GA, Devree BT, Sunahara RK, Kobilka BK. PMID: 19763081.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    54. Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. J Pharmacol Exp Ther. 2009 Nov; 331(2):445-55. Collins GT, Brim RL, Narasimhan D, Ko MC, Sunahara RK, Zhan CG, Woods JH. PMID: 19710369.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    55. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. J Biol Chem. 2009 Sep 25; 284(39):26732-41. Kuszak AJ, Pitchiaya S, Anand JP, Mosberg HI, Walter NG, Sunahara RK. PMID: 19542234.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    56. The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9501-6. Yao XJ, Vélez Ruiz G, Whorton MR, Rasmussen SG, DeVree BT, Deupi X, Sunahara RK, Kobilka B. PMID: 19470481.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    57. Effects of cocaine esterase following its repeated administration with cocaine in mice. Drug Alcohol Depend. 2009 May 01; 101(3):202-9. Ko MC, Narasimhan D, Berlin AA, Lukacs NW, Sunahara RK, Woods JH. PMID: 19217723.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    58. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. J Pharmacol Exp Ther. 2009 Apr; 329(1):210-7. Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, Woods JH. PMID: 19136638.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    59. A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. Ann Emerg Med. 2009 Sep; 54(3):409-20. Jutkiewicz EM, Baladi MG, Cooper ZD, Narasimhan D, Sunahara RK, Woods JH. PMID: 19013687.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    60. Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Mol Pharmacol. 2009 Feb; 75(2):318-23. Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG. PMID: 18987161.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    61. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem. 2008 Feb 15; 283(7):4387-94. Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK. PMID: 18033822.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    62. Detection of g protein coupled receptor mediated adenylyl cyclase activity by capillary electrophoresis using fluorescently labeled ATP. Anal Chem. 2007 Oct 01; 79(19):7534-9. Cunliffe JM, Sunahara RK, Kennedy RT. PMID: 17718540.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    63. A CE assay for the detection of agonist-stimulated adenylyl cyclase activity. Electrophoresis. 2007 Jun; 28(12):1913-20. Cunliffe JM, Whorton MR, Sunahara RK, Kennedy RT. PMID: 17480040.
      View in: PubMed   Mentions:    Fields:    Translation:CellsPHPublic Health
    64. Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening. Comb Chem High Throughput Screen. 2007 May; 10(4):289-98. Vadakkadathmeethal K, Cunliffe JM, Swift J, Kennedy RT, Neubig RR, Sunahara RK. PMID: 17506713.
      View in: PubMed   Mentions:    Fields:    
    65. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7682-7. Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, Sunahara RK. PMID: 17452637.
      View in: PubMed   Mentions: 286     Fields:    Translation:HumansAnimalsCells
    66. Under the microscope: single molecule symposium at the University of Michigan, 2006. Biopolymers. 2007 Feb 05; 85(2):106-14. Walter NG, Meiners JC, Meyhofer E, Neubig RR, Sunahara RK, Perkins NC, Steel DG, Swanson JA. PMID: 17080420.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    67. SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1805-10. Benson MD, Li QJ, Kieckhafer K, Dudek D, Whorton MR, Sunahara RK, Iñiguez-Lluhí JA, Martens JR. PMID: 17261810.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    68. N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. Mol Pharmacol. 2007 Apr; 71(4):1040-50. Bodenstein J, Sunahara RK, Neubig RR. PMID: 17220356.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    69. Cocaine esterase: interactions with cocaine and immune responses in mice. J Pharmacol Exp Ther. 2007 Feb; 320(2):926-33. Ko MC, Bowen LD, Narasimhan D, Berlin AA, Lukacs NW, Sunahara RK, Cooper ZD, Woods JH. PMID: 17114567.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    70. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Mol Pharmacol. 2007 Jan; 71(1):169-75. Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. PMID: 17012620.
      View in: PubMed   Mentions: 67     Fields:    Translation:Cells
    71. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol. 2006 Dec; 70(6):1885-91. Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, Woods JH. PMID: 16968810.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    72. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chem Biol Drug Des. 2006 Apr; 67(4):266-74. Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. PMID: 16629824.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    73. Detection of adenylyl cyclase activity using a fluorescent ATP substrate and capillary electrophoresis. Anal Chem. 2006 Mar 15; 78(6):1731-8. Cunliffe JM, Sunahara RK, Kennedy RT. PMID: 16536404.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    74. ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6. Cell Signal. 2006 Nov; 18(11):1988-94. Giguère P, Rochdi MD, Laroche G, Dupré E, Whorton MR, Sunahara RK, Claing A, Dupuis G, Parent JL. PMID: 16650966.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    75. Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry. 2005 Dec 13; 44(49):16333-40. Morishima Y, Peng HM, Lin HL, Hollenberg PF, Sunahara RK, Osawa Y, Pratt WB. PMID: 16331994.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    76. Cloning and characterization of the G protein betagamma subunits from Trichoplusia ni (High Five cells). Insect Biochem Mol Biol. 2005 Apr; 35(4):333-45. Vadakkadathmeethal K, Felczak A, Davignon I, Collins J, Sunahara RK. PMID: 15763469.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    77. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J Lipid Res. 2005 Jun; 46(6):1239-47. Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN. PMID: 15772423.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansCells
    78. Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclase. J Biol Chem. 2005 Mar 25; 280(12):11513-9. Chang FJ, Lemme S, Sun Q, Sunahara RK, Beuve A. PMID: 15649897.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    79. Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues. J Biol Chem. 2005 Mar 04; 280(9):7712-9. Jameson EE, Roof RA, Whorton MR, Mosberg HI, Sunahara RK, Neubig RR, Kennedy RT. PMID: 15613467.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    80. Affinity assays using fluorescence anisotropy with capillary electrophoresis separation. Anal Chem. 2004 Dec 15; 76(24):7380-6. Whelan RJ, Sunahara RK, Neubig RR, Kennedy RT. PMID: 15595883.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    81. Zinc inhibition of adenylyl cyclase correlates with conformational changes in the enzyme. Cell Signal. 2004 Oct; 16(10):1177-85. Klein C, Heyduk T, Sunahara RK. PMID: 15240012.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    82. Differentially regulated expression of endogenous RGS4 and RGS7. J Biol Chem. 2004 Jan 23; 279(4):2593-9. Krumins AM, Barker SA, Huang C, Sunahara RK, Yu K, Wilkie TM, Gold SJ, Mumby SM. PMID: 14604980.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    83. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J Biol Chem. 2003 Dec 05; 278(49):48754-63. Morishima Y, Kanelakis KC, Murphy PJ, Lowe ER, Jenkins GJ, Osawa Y, Sunahara RK, Pratt WB. PMID: 14507910.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    84. Detection of G proteins by affinity probe capillary electrophoresis using a fluorescently labeled GTP analogue. Anal Chem. 2003 Aug 15; 75(16):4297-304. Jameson EE, Cunliffe JM, Neubig RR, Sunahara RK, Kennedy RT. PMID: 14632149.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    85. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv. 2002 Jun; 2(3):168-84. Sunahara RK, Taussig R. PMID: 14993377.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    86. Zinc inhibition of cAMP signaling. J Biol Chem. 2002 Apr 05; 277(14):11859-65. Klein C, Sunahara RK, Hudson TY, Heyduk T, Howlett AC. PMID: 11805091.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    87. Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. Methods Enzymol. 2002; 345:127-40. Hatley ME, Gilman AG, Sunahara RK. PMID: 11665600.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    88. Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha. Methods Enzymol. 2002; 345:198-206. Tesmer JJ, Sunahara RK, Fancy DA, Gilman AG, Sprang SR. PMID: 11665605.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells