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    Clement Boland

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0956
    CA La Jolla 92093
    Phone858-249-0772
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      UCSF, San Francisco, CAGI Fellowship1981GI Cancer Research
      Yale Univ School of Medicine, New Haven, CTMD1973Medicine
      Univ of Notre Dame, South Bend, INBA1969Liberal Arts
      Collapse Awards and Honors
      Univ of Michigan2017  - presC. Richard Boland Distinguished Professorship
      AGA2016Friedenwald Medal
      Collaborative Group of the Americas2015Lifetime Achievement Award
      AGA2015Beaumont Prize in Gastroenterology
      AGA2011  - 2012President
      AGA Oncology Section2001Distinguished Mentor Award
      AAP2001  - presElected Member
      AGA1992  - 1993Funderburg Award

      Collapse Research 
      Collapse Research Activities and Funding
      Investing in the Future to Promote Diversity in GI Training
      NIH/NIDDK R25DK096968Sep 10, 2012 - Aug 31, 2017
      Role: Principal Investigator
      JC Virus and Human Colorectal Neoplasia
      NIH/NCI R01CA098572Dec 1, 2002 - Jan 31, 2015
      Role: Principal Investigator
      Familial and Early Onset Colorectal Cancer
      NIH/NCI R01CA072851May 10, 1996 - Jul 31, 2020
      Role: Co-Principal Investigator
      MUCIN FAMILIES IN THE GASTROINTESTINAL TRACT
      NIH/NCI R55CA039233Sep 30, 1993 - Jun 30, 1994
      Role: Principal Investigator
      C/EBP BETA IN HEPATOCYTE GENE EXPRESSION &PROLIFERATION
      NIH/NIDDK R01DK046971Jul 15, 1993 - Aug 31, 2003
      Role: Co-Principal Investigator
      REGULATION OF GASTRIC MUCIN SYNTHESIS
      NIH/NIDDK R01DK037989May 1, 1988 - Apr 30, 1992
      Role: Principal Investigator
      MUCIN FAMILIES IN GASTROINTESTINAL TRACT
      NIH/NCI R01CA039233Aug 1, 1981 - Apr 30, 2000
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Boland C. Erratum to: Non-coding RNA: It's Not Junk. Dig Dis Sci. 2017 Sep 06. PMID: 28879425.
        View in: PubMed
      2. Wodarz D, Goel A, Boland C, Komarova NL. Effect of aspirin on tumour cell colony formation and evolution. J R Soc Interface. 2017 Sep; 14(134). PMID: 28878032.
        View in: PubMed
      3. Boland C, Yurgelun MB. Mutational cascades in cancer. Oncotarget. 2017 Jun 27; 8(26):41784-41785. PMID: 28620150.
        View in: PubMed
      4. Rex DK, Boland C, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ. Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017 Jul; 153(1):307-323. PMID: 28600072.
        View in: PubMed
      5. Rex DK, Boland C, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ. Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2017 Jul; 112(7):1016-1030. PMID: 28555630.
        View in: PubMed
      6. Richard Boland C. Non-coding RNA: It's Not Junk. Dig Dis Sci. 2017 May; 62(5):1107-1109. PMID: 28271304.
        View in: PubMed
      7. Durno C, Boland C, Cohen S, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ, Rex DK. Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017 May; 152(6):1605-1614. PMID: 28363489.
        View in: PubMed
      8. Durno C, Boland C, Cohen S, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ, Rex DK. Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2017 May; 112(5):682-690. PMID: 28349994.
        View in: PubMed
      9. Boland C, Yurgelun MB. Historical Perspective on Familial Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2017 Mar; 3(2):192-200. PMID: 28275686.
        View in: PubMed
      10. Zumwalt TJ, Wodarz D, Komarova NL, Toden S, Turner J, Cardenas J, Burn J, Chan AT, Boland C, Goel A. Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells. Cancer Prev Res (Phila). 2017 Mar; 10(3):208-218. PMID: 28154202.
        View in: PubMed
      11. Shia J, Schultz N, Kuk D, Vakiani E, Middha S, Segal NH, Hechtman JF, Berger MF, Stadler ZK, Weiser MR, Wolchok JD, Boland C, Gönen M, Klimstra DS. Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications. Mod Pathol. 2017 Apr; 30(4):599-609. PMID: 27982025.
        View in: PubMed
      12. Yurgelun MB, Boland C. "New" Cancer Genes and Inherited Colorectal Cancer Risk: Caveat Emptor. Gastroenterology. 2017 Jan; 152(1):12-13. PMID: 27889571.
        View in: PubMed
      13. Robertson DJ, Lee JK, Boland C, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Rex DK. Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017 Apr; 152(5):1217-1237.e3. PMID: 27769517.
        View in: PubMed
      14. Robertson DJ, Lee JK, Boland C, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Rex DK. Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2017 Jan; 112(1):37-53. PMID: 27753435.
        View in: PubMed
      15. Robertson DJ, Lee JK, Boland C, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Rex DK. Recommendations on fecal immunochemical testing to screen for colorectal neoplasia: a consensus statement by the US Multi-Society Task Force on colorectal cancer. Gastrointest Endosc. 2017 Jan; 85(1):2-21.e3. PMID: 27769516.
        View in: PubMed
      16. Shigeyasu K, Okugawa Y, Toden S, Boland C, Goel A. Exportin-5 Functions as an Oncogene and a Potential Therapeutic Target in Colorectal Cancer. Clin Cancer Res. 2017 Mar 01; 23(5):1312-1322. PMID: 27553833.
        View in: PubMed
      17. Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F, Bhattacharyya A, Hsu CH, Chow SH, Ahnen DJ, Boland C, Heigh RI, Fay DE, Hamilton SR, Jacobs ET, Martinez EM, Alberts DS, Lance P. Celecoxib for the Prevention of Colorectal Adenomas: Results of a Suspended Randomized Controlled Trial. J Natl Cancer Inst. 2016 Dec; 108(12). PMID: 27530656.
        View in: PubMed
      18. Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F, Bhattacharyya A, Hsu CH, Chow HH, Ahnen DJ, Boland C, Heigh RI, Fay DE, Hamilton SR, Jacobs ET, Martinez ME, Alberts DS, Lance P. Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes. J Natl Cancer Inst. 2016 Dec; 108(12). PMID: 27530657.
        View in: PubMed
      19. Boland C. Recent discoveries in the molecular genetics of Lynch syndrome. Fam Cancer. 2016 Jul; 15(3):395-403. PMID: 27038793.
        View in: PubMed
      20. Lowery JT, Ahnen DJ, Schroy PC, Hampel H, Baxter N, Boland C, Burt RW, Butterly L, Doerr M, Doroshenk M, Feero WG, Henrikson N, Ladabaum U, Lieberman D, McFarland EG, Peterson SK, Raymond M, Samadder NJ, Syngal S, Weber TK, Zauber AG, Smith R. Understanding the contribution of family history to colorectal cancer risk and its clinical implications: A state-of-the-science review. Cancer. 2016 Sep 01; 122(17):2633-45. PMID: 27258162.
        View in: PubMed
      21. Moreno-Ortiz JM, Ayala-Madrigal Mde L, Corona-Rivera JR, Centeno-Flores M, Maciel-Gutiérrez V, Franco-Topete RA, Armendáriz-Borunda J, Hotchkiss E, Pérez-Carbonell L, Rhees J, Boland C, Gutiérrez-Angulo M. Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome. Gastroenterol Res Pract. 2016; 2016:5278024. PMID: 27247567; PMCID: PMC4877485.
      22. Kahi CJ, Boland C, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Robertson DJ, Rex DK. Colonoscopy Surveillance After Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2016 Mar; 150(3):758-768.e11. PMID: 26892199.
        View in: PubMed
      23. Boland C, Goel A. Prognostic Subgroups among Patients with Stage II Colon Cancer. N Engl J Med. 2016 Jan 21; 374(3):277-8. PMID: 26789877; PMCID: PMC4852473 [Available on 01/21/17].
      24. Kahi CJ, Boland C, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Robertson DJ, Rex DK. Colonoscopy surveillance after colorectal cancer resection: recommendations of the US multi-society task force on colorectal cancer. Gastrointest Endosc. 2016 Mar; 83(3):489-98.e10. PMID: 26802191.
        View in: PubMed
      25. Koi M, Garcia M, Choi C, Kim HR, Koike J, Hemmi H, Nagasaka T, Okugawa Y, Toiyama Y, Kitajima T, Imaoka H, Kusunoki M, Chen YH, Mukherjee B, Boland C, Carethers JM. Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis. Gastroenterology. 2016 Apr; 150(4):944-55. PMID: 26752111; PMCID: PMC4808397 [Available on 04/01/17].
      26. Hur K, Toiyama Y, Okugawa Y, Ide S, Imaoka H, Boland C, Goel A. Circulating microRNA-203 predicts prognosis and metastasis in human colorectal cancer. Gut. 2017 Apr; 66(4):654-665. PMID: 26701878.
        View in: PubMed
      27. Okugawa Y, Toiyama Y, Toden S, Mitoma H, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland C, Goel A. Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer. Gut. 2017 Jan; 66(1):107-117. PMID: 26475630.
        View in: PubMed
      28. Antelo M, Milito D, Rhees J, Roca E, Barugel M, Cuatrecasas M, Moreira L, Leoz ML, Carballal S, Ocaña T, Pellisé M, Castells A, Boland C, Goel A, Balaguer F. Pitfalls in the diagnosis of biallelic PMS2 mutations. Fam Cancer. 2015 Sep; 14(3):411-4. PMID: 25773960.
        View in: PubMed
      29. Stoffel EM, Boland C. Genetics and Genetic Testing in Hereditary Colorectal Cancer. Gastroenterology. 2015 Oct; 149(5):1191-1203.e2. PMID: 26226567.
        View in: PubMed
      30. Perez-Carbonell L, Sinicrope FA, Alberts SR, Oberg AL, Balaguer F, Castells A, Boland C, Goel A. MiR-320e is a novel prognostic biomarker in colorectal cancer. Br J Cancer. 2015 Jun 30; 113(1):83-90. PMID: 26035698; PMCID: PMC4647533.
      31. Yamada A, Horimatsu T, Okugawa Y, Nishida N, Honjo H, Ida H, Kou T, Kusaka T, Sasaki Y, Yagi M, Higurashi T, Yukawa N, Amanuma Y, Kikuchi O, Muto M, Ueno Y, Nakajima A, Chiba T, Boland C, Goel A. Serum miR-21, miR-29a, and miR-125b Are Promising Biomarkers for the Early Detection of Colorectal Neoplasia. Clin Cancer Res. 2015 Sep 15; 21(18):4234-42. PMID: 26038573; PMCID: PMC4573815.
      32. Lamba AR, Moore AY, Moore T, Rhees J, Arnold MA, Boland C. Defective DNA mismatch repair activity is common in sebaceous neoplasms, and may be an ineffective approach to screen for Lynch syndrome. Fam Cancer. 2015 Jun; 14(2):259-64. PMID: 25637498.
        View in: PubMed
      33. Wei C, Peng B, Han Y, Chen WV, Rother J, Tomlinson GE, Boland C, Chaussabel D, Chaussabel M, Frazier ML, Amos CI. Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers. Fam Cancer. 2015 Jun; 14(2):297-306. PMID: 25716654; PMCID: PMC4589301.
      34. Goodenberger ML, Thomas BC, Riegert-Johnson D, Boland C, Plon SE, Clendenning M, Win AK, Senter L, Lipkin SM, Stadler ZK, Macrae FA, Lynch HT, Weitzel JN, de la Chapelle A, Syngal S, Lynch P, Parry S, Jenkins MA, Gallinger S, Holter S, Aronson M, Newcomb PA, Burnett T, Le Marchand L, Pichurin P, Hampel H, Terdiman JP, Lu KH, Thibodeau S, Lindor NM. PMS2 monoallelic mutation carriers: the known unknown. Genet Med. 2016 Jan; 18(1):13-9. PMID: 25856668; PMCID: PMC4834863.
      35. Shia J, Stadler ZK, Weiser MR, Vakiani E, Mendelsohn R, Markowitz AJ, Shike M, Boland C, Klimstra DS. Mismatch repair deficient-crypts in non-neoplastic colonic mucosa in Lynch syndrome: insights from an illustrative case. Fam Cancer. 2015 Mar; 14(1):61-8. PMID: 25173403.
        View in: PubMed
      36. Toden S, Okugawa Y, Buhrmann C, Nattamai D, Anguiano E, Baldwin N, Shakibaei M, Boland C, Goel A. Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. Cancer Prev Res (Phila). 2015 May; 8(5):431-43. PMID: 25712055; PMCID: PMC4417447.
      37. Zumwalt TJ, Arnold M, Goel A, Boland C. Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration. Oncotarget. 2015 Feb 20; 6(5):2981-91. PMID: 25671296; PMCID: PMC4413778.
      38. Hur K, Toiyama Y, Schetter AJ, Okugawa Y, Harris CC, Boland C, Goel A. Identification of a metastasis-specific MicroRNA signature in human colorectal cancer. J Natl Cancer Inst. 2015 Mar; 107(3). PMID: 25663689; PMCID: PMC4334826.
      39. Toden S, Okugawa Y, Jascur T, Wodarz D, Komarova NL, Buhrmann C, Shakibaei M, Boland C, Goel A. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis. 2015 Mar; 36(3):355-67. PMID: 25653233; PMCID: PMC4400529.
      40. Moreira L, Muñoz J, Cuatrecasas M, Quintanilla I, Leoz ML, Carballal S, Ocaña T, López-Cerón M, Pellise M, Castellví-Bel S, Jover R, Andreu M, Carracedo A, Xicola RM, Llor X, Boland C, Goel A, Castells A, Balaguer F. Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancer. Cancer. 2015 May 01; 121(9):1395-404. PMID: 25557234.
        View in: PubMed
      41. Yamada A, Cox MA, Gaffney KA, Moreland A, Boland C, Goel A. Technical factors involved in the measurement of circulating microRNA biomarkers for the detection of colorectal neoplasia. PLoS One. 2014; 9(11):e112481. PMID: 25405754; PMCID: PMC4236069.
      42. Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland C, Goel A. Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis. 2014 Dec; 35(12):2731-9. PMID: 25280565; PMCID: PMC4247518.
      43. Johnson DA, Barkun AN, Cohen LB, Dominitz JA, Kaltenbach T, Martel M, Robertson DJ, Boland C, Giardello FM, Lieberman DA, Levin TR, Rex DK. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer. Gastroenterology. 2014 Oct; 147(4):903-24. PMID: 25239068.
        View in: PubMed
      44. Perez-Carbonell L, Balaguer F, Toiyama Y, Egoavil C, Rojas E, Guarinos C, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. IGFBP3 methylation is a novel diagnostic and predictive biomarker in colorectal cancer. PLoS One. 2014; 9(8):e104285. PMID: 25127039; PMCID: PMC4134211.
      45. Giardiello FM, Allen JI, Axilbund JE, Boland C, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer. Dis Colon Rectum. 2014 Aug; 57(8):1025-48. PMID: 25003300.
        View in: PubMed
      46. Giardiello FM, Allen JI, Axilbund JE, Boland C, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the U.S. Multi-Society Task Force on Colorectal Cancer. Gastrointest Endosc. 2014 Aug; 80(2):197-220. PMID: 25034835.
        View in: PubMed
      47. Giardiello FM, Allen JI, Axilbund JE, Boland C, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer. Gastroenterology. 2014 Aug; 147(2):502-26. PMID: 25043945.
        View in: PubMed
      48. Giardiello FM, Allen JI, Axilbund JE, Boland C, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer. Am J Gastroenterol. 2014 Aug; 109(8):1159-79. PMID: 25070057.
        View in: PubMed
      49. Butcher LD, Garcia M, Arnold M, Ueno H, Goel A, Boland C. Immune response to JC virus T antigen in patients with and without colorectal neoplasia. Gut Microbes. 2014 Jul 01; 5(4):468-75. PMID: 25007286.
        View in: PubMed
      50. Link A, Balaguer F, Nagasaka T, Boland C, Goel A. MicroRNA miR-J1-5p as a potential biomarker for JC virus infection in the gastrointestinal tract. PLoS One. 2014; 9(6):e100036. PMID: 24932487; PMCID: PMC4059717.
      51. Rhees J, Arnold M, Boland C. Inversion of exons 1-7 of the MSH2 gene is a frequent cause of unexplained Lynch syndrome in one local population. Fam Cancer. 2014 Jun; 13(2):219-25. PMID: 24114314; PMCID: PMC3984383.
      52. Yamada A, Minamiguchi S, Sakai Y, Horimatsu T, Muto M, Chiba T, Boland C, Goel A. Colorectal advanced neoplasms occur through dual carcinogenesis pathways in individuals with coexisting serrated polyps. PLoS One. 2014; 9(5):e98059. PMID: 24849572; PMCID: PMC4029807.
      53. Toiyama Y, Hur K, Tanaka K, Inoue Y, Kusunoki M, Boland C, Goel A. Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancer. Ann Surg. 2014 Apr; 259(4):735-43. PMID: 23982750; PMCID: PMC4032090.
      54. Toiyama Y, Boland C, Goel A. Response. J Natl Cancer Inst. 2014 Mar; 106(3):djt458. PMID: 24586104.
        View in: PubMed
      55. Wodarz D, Boland C, Goel A, Komarova NL. Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines. Biol Direct. 2013 Jun 11; 8:14. PMID: 23758948; PMCID: PMC3691599.
      56. Toiyama Y, Takahashi M, Hur K, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland C, Goel A. Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst. 2013 Jun 19; 105(12):849-59. PMID: 23704278; PMCID: PMC3687369.
      57. Hur K, Cejas P, Feliu J, Moreno-Rubio J, Burgos E, Boland C, Goel A. Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. Gut. 2014 Apr; 63(4):635-46. PMID: 23704319; PMCID: PMC3884067.
      58. Piazzi G, Selgrad M, Garcia M, Ceccarelli C, Fini L, Bianchi P, Laghi L, D'Angelo L, Paterini P, Malfertheiner P, Chieco P, Boland C, Bazzoli F, Ricciardiello L. Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers. Br J Cancer. 2013 Apr 30; 108(8):1750-6. PMID: 23579212; PMCID: PMC3668461.
      59. Boland C. The mystery of mismatch repair deficiency: lynch or lynch-like? Gastroenterology. 2013 May; 144(5):868-70. PMID: 23523847; PMCID: PMC3647610.
      60. Link A, Balaguer F, Shen Y, Lozano JJ, Leung HC, Boland C, Goel A. Curcumin modulates DNA methylation in colorectal cancer cells. PLoS One. 2013; 8(2):e57709. PMID: 23460897; PMCID: PMC3584082.
      61. Shah KR, Boland C, Patel M, Thrash B, Menter A. Cutaneous manifestations of gastrointestinal disease: part I. J Am Acad Dermatol. 2013 Feb; 68(2):189.e1-21; quiz 210. PMID: 23317980.
        View in: PubMed
      62. Thrash B, Patel M, Shah KR, Boland C, Menter A. Cutaneous manifestations of gastrointestinal disease: part II. J Am Acad Dermatol. 2013 Feb; 68(2):211.e1-33; quiz 244-6. PMID: 23317981.
        View in: PubMed
      63. Thompson P, Roe DJ, Fales L, Buckmeier J, Wang F, Hamilton SR, Bhattacharyya A, Green S, Hsu CH, Chow HH, Ahnen DJ, Boland C, Heigh RI, Fay DE, Martinez ME, Jacobs E, Ashbeck EL, Alberts DS, Lance P. Design and baseline characteristics of participants in a phase III randomized trial of celecoxib and selenium for colorectal adenoma prevention. Cancer Prev Res (Phila). 2012 Dec; 5(12):1381-93. PMID: 23060037; PMCID: PMC3518663.
      64. Takahashi M, Cuatrecasas M, Balaguer F, Hur K, Toiyama Y, Castells A, Boland C, Goel A. The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer. PLoS One. 2012; 7(10):e46684. PMID: 23056401; PMCID: PMC3463512.
      65. Williams JC, Hamilton JK, Shiller M, Fischer L, Deprisco G, Boland C. Combined juvenile polyposis and hereditary hemorrhagic telangiectasia. Proc (Bayl Univ Med Cent). 2012 Oct; 25(4):360-4. PMID: 23077388; PMCID: PMC3448579.
      66. Antelo M, Balaguer F, Shia J, Shen Y, Hur K, Moreira L, Cuatrecasas M, Bujanda L, Giraldez MD, Takahashi M, Cabanne A, Barugel ME, Arnold M, Roca EL, Andreu M, Castellvi-Bel S, Llor X, Jover R, Castells A, Boland C, Goel A. A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer. PLoS One. 2012; 7(9):e45357. PMID: 23049789; PMCID: PMC3458035.
      67. Goel A, Boland C. Epigenetics of colorectal cancer. Gastroenterology. 2012 Dec; 143(6):1442-1460.e1. PMID: 23000599; PMCID: PMC3611241.
      68. Takahashi M, Sung B, Shen Y, Hur K, Link A, Boland C, Aggarwal BB, Goel A. Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family. Carcinogenesis. 2012 Dec; 33(12):2441-9. PMID: 22983985; PMCID: PMC3510738.
      69. Shia J, Zhang L, Shike M, Guo M, Stadler Z, Xiong X, Tang LH, Vakiani E, Katabi N, Wang H, Bacares R, Ruggeri J, Boland C, Ladanyi M, Klimstra DS. Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency. Mod Pathol. 2013 Jan; 26(1):131-8. PMID: 22918162; PMCID: PMC3793326.
      70. Boland C, Krejs G, Emmett M, Richardson C. A birthday celebration for John S. Fordtran, MD. Proc (Bayl Univ Med Cent). 2012 Jul; 25(3):250-3. PMID: 22754128; PMCID: PMC3377294.
      71. Hur K, Toiyama Y, Takahashi M, Balaguer F, Nagasaka T, Koike J, Hemmi H, Koi M, Boland C, Goel A. MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut. 2013 Sep; 62(9):1315-26. PMID: 22735571; PMCID: PMC3787864.
      72. Boland C. Lynch syndrome: new tales from the crypt. Lancet Oncol. 2012 Jun; 13(6):562-4. PMID: 22552010; PMCID: PMC3805503.
      73. Shen Y, Takahashi M, Byun HM, Link A, Sharma N, Balaguer F, Leung HC, Boland C, Goel A. Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells. Cancer Biol Ther. 2012 May; 13(7):542-52. PMID: 22415137; PMCID: PMC3364790.
      74. Garcia M, Choi C, Kim HR, Daoud Y, Toiyama Y, Takahashi M, Goel A, Boland C, Koi M. Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability. Gastroenterology. 2012 Jul; 143(1):48-50.e1. PMID: 22465427; PMCID: PMC3383934.
      75. Kathiria AS, Butcher LD, Feagins LA, Souza RF, Boland C, Theiss AL. Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. PLoS One. 2012; 7(2):e31231. PMID: 22363587; PMCID: PMC3281932.
      76. Li J, Koike J, Kugoh H, Arita M, Ohhira T, Kikuchi Y, Funahashi K, Takamatsu K, Boland C, Koi M, Hemmi H. Down-regulation of MutS homolog 3 by hypoxia in human colorectal cancer. Biochim Biophys Acta. 2012 Apr; 1823(4):889-99. PMID: 22343000; PMCID: PMC3793328.
      77. Yurgelun MB, Goel A, Hornick JL, Sen A, Turgeon DK, Ruffin MT, Marcon NE, Baron JA, Bresalier RS, Syngal S, Brenner DE, Boland C, Stoffel EM. Microsatellite instability and DNA mismatch repair protein deficiency in Lynch syndrome colorectal polyps. Cancer Prev Res (Phila). 2012 Apr; 5(4):574-82. PMID: 22262812; PMCID: PMC3461594.
      78. Piazzi G, Fini L, Selgrad M, Garcia M, Daoud Y, Wex T, Malfertheiner P, Gasbarrini A, Romano M, Meyer RL, Genta RM, Fox JG, Boland C, Bazzoli F, Ricciardiello L. Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer. Oncotarget. 2011 Dec; 2(12):1291-301. PMID: 22249198; PMCID: PMC3282085.
      79. Balaguer F, Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M, Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover R, Llor X, Castells A, Boland C, Gironella M, Goel A. Colorectal cancers with microsatellite instability display unique miRNA profiles. Clin Cancer Res. 2011 Oct 01; 17(19):6239-49. PMID: 21844009; PMCID: PMC3186834.
      80. Ladabaum U, Wang G, Terdiman J, Blanco A, Kuppermann M, Boland C, Ford J, Elkin E, Phillips KA. Strategies to identify the Lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis. Ann Intern Med. 2011 Jul 19; 155(2):69-79. PMID: 21768580; PMCID: PMC3793257.
      81. Lynch HT, Riegert-Johnson DL, Snyder C, Lynch JF, Hagenkord J, Boland C, Rhees J, Thibodeau SN, Boardman LA, Davies J, Kuiper RP, Hoogerbrugge N, Ligtenberg MJ. Lynch syndrome-associated extracolonic tumors are rare in two extended families with the same EPCAM deletion. Am J Gastroenterol. 2011 Oct; 106(10):1829-36. PMID: 21769135; PMCID: PMC3805505.
      82. Jascur T, Fotedar R, Greene S, Hotchkiss E, Boland C. N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1. J Biol Chem. 2011 Aug 26; 286(34):29531-9. PMID: 21725088; PMCID: PMC3190993.
      83. Fini L, Piazzi G, Daoud Y, Selgrad M, Maegawa S, Garcia M, Fogliano V, Romano M, Graziani G, Vitaglione P, Carmack SW, Gasbarrini A, Genta RM, Issa JP, Boland C, Ricciardiello L. Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract. Cancer Prev Res (Phila). 2011 Jun; 4(6):907-15. PMID: 21383028; PMCID: PMC3793841.
      84. Goel A, Nguyen TP, Leung HC, Nagasaka T, Rhees J, Hotchkiss E, Arnold M, Banerji P, Koi M, Kwok CT, Packham D, Lipton L, Boland C, Ward RL, Hitchins MP. De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one. Int J Cancer. 2011 Feb 15; 128(4):869-78. PMID: 20473912; PMCID: PMC3794437.
      85. Takahashi M, Koi M, Balaguer F, Boland C, Goel A. MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin, and a poly(ADP-ribose) polymerase inhibitor. J Biol Chem. 2011 Apr 08; 286(14):12157-65. PMID: 21285347; PMCID: PMC3069420.
      86. Koi M, Boland C. Tumor hypoxia and genetic alterations in sporadic cancers. J Obstet Gynaecol Res. 2011 Feb; 37(2):85-98. PMID: 21272156; PMCID: PMC3079283.
      87. Gasche JA, Hoffmann J, Boland C, Goel A. Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells. Int J Cancer. 2011 Sep 01; 129(5):1053-63. PMID: 21710491; PMCID: PMC3110561.
      88. Boland C. Speed kills. Clin Gastroenterol Hepatol. 2011 Apr; 9(4):290-2. PMID: 21195793; PMCID: PMC3085133.
      89. Jover R, Nguyen TP, Pérez-Carbonell L, Zapater P, Payá A, Alenda C, Rojas E, Cubiella J, Balaguer F, Morillas JD, Clofent J, Bujanda L, Reñé JM, Bessa X, Xicola RM, Nicolás-Pérez D, Castells A, Andreu M, Llor X, Boland C, Goel A. 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer. Gastroenterology. 2011 Apr; 140(4):1174-81. PMID: 21185836; PMCID: PMC3073650.
      90. Ramamoorthy S, Devaraj B, Miyai K, Luo L, Liu YT, Boland C, Goel A, Carethers JM. John Cunningham virus T-antigen expression in anal carcinoma. Cancer. 2011 Jun 01; 117(11):2379-85. PMID: 24048785; PMCID: PMC3060305.
      91. Dinh TA, Rosner BI, Atwood JC, Boland C, Syngal S, Vasen HF, Gruber SB, Burt RW. Health benefits and cost-effectiveness of primary genetic screening for Lynch syndrome in the general population. Cancer Prev Res (Phila). 2011 Jan; 4(1):9-22. PMID: 21088223; PMCID: PMC3793254.
      92. Boland C. Chronic inflammation, colorectal cancer and gene polymorphisms. Dig Dis. 2010; 28(4-5):590-5. PMID: 21088407; PMCID: PMC2997443.
      93. Gupta S, Ashfaq R, Kapur P, Afonso BB, Nguyen TP, Ansari F, Boland C, Goel A, Rockey DC. Microsatellite instability among individuals of Hispanic origin with colorectal cancer. Cancer. 2010 Nov 01; 116(21):4965-72. PMID: 20665498; PMCID: PMC2963686.
      94. Fini L, Piazzi G, Ceccarelli C, Daoud Y, Belluzzi A, Munarini A, Graziani G, Fogliano V, Selgrad M, Garcia M, Gasbarrini A, Genta RM, Boland C, Ricciardiello L. Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in Apc(Min/+) mice. Clin Cancer Res. 2010 Dec 01; 16(23):5703-11. PMID: 21030497; PMCID: PMC3795521.
      95. Giráldez MD, Balaguer F, Bujanda L, Cuatrecasas M, Muñoz J, Alonso-Espinaco V, Larzabal M, Petit A, Gonzalo V, Ocaña T, Moreira L, Enríquez-Navascués JM, Boland C, Goel A, Castells A, Castellví-Bel S. MSH6 and MUTYH deficiency is a frequent event in early-onset colorectal cancer. Clin Cancer Res. 2010 Nov 15; 16(22):5402-13. PMID: 20924129; PMCID: PMC3032288.
      96. Balaguer F, Link A, Lozano JJ, Cuatrecasas M, Nagasaka T, Boland C, Goel A. Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis. Cancer Res. 2010 Aug 15; 70(16):6609-18. PMID: 20682795; PMCID: PMC2922409.
      97. Goel A, Nagasaka T, Spiegel J, Meyer R, Lichliter WE, Boland C. Low frequency of Lynch syndrome among young patients with non-familial colorectal cancer. Clin Gastroenterol Hepatol. 2010 Nov; 8(11):966-71. PMID: 20655395; PMCID: PMC2964436.
      98. Boland C, Goel A. Clearing the air on smoking and colorectal cancer. J Natl Cancer Inst. 2010 Jul 21; 102(14):996-7. PMID: 20587791; PMCID: PMC2907409.
      99. Yashiro M, Hirakawa K, Boland C. Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability. BMC Cancer. 2010 Jun 18; 10:303. PMID: 20565851; PMCID: PMC2927997.
      100. Link A, Balaguer F, Shen Y, Nagasaka T, Lozano JJ, Boland C, Goel A. Fecal MicroRNAs as novel biomarkers for colon cancer screening. Cancer Epidemiol Biomarkers Prev. 2010 Jul; 19(7):1766-74. PMID: 20551304; PMCID: PMC2901410.
      101. Boland C, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010 Jun; 138(6):2073-2087.e3. PMID: 20420947; PMCID: PMC3037515.
      102. Campregher C, Scharl T, Nemeth M, Honeder C, Jascur T, Boland C, Gasche C. The nucleotide composition of microsatellites impacts both replication fidelity and mismatch repair in human colorectal cells. Hum Mol Genet. 2010 Jul 01; 19(13):2648-57. PMID: 20421367; PMCID: PMC2883347.
      103. Boland C, Shike M. Report from the Jerusalem workshop on Lynch syndrome-hereditary nonpolyposis colorectal cancer. Gastroenterology. 2010 Jun; 138(7):2197.e1-7. PMID: 20416305; PMCID: PMC3032350.
      104. Nagasaka T, Rhees J, Kloor M, Gebert J, Naomoto Y, Boland C, Goel A. Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers. Cancer Res. 2010 Apr 15; 70(8):3098-108. PMID: 20388775; PMCID: PMC2856102.
      105. Goel A, Nagasaka T, Hamelin R, Boland C. An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers. PLoS One. 2010 Feb 24; 5(2):e9393. PMID: 20195377; PMCID: PMC2827558.
      106. Yamada K, Kanazawa S, Koike J, Sugiyama H, Xu C, Funahashi K, Boland C, Koi M, Hemmi H. Microsatellite instability at tetranucleotide repeats in sporadic colorectal cancer in Japan. Oncol Rep. 2010 Feb; 23(2):551-61. PMID: 20043121; PMCID: PMC2846616.
      107. Goel A, Xicola RM, Nguyen TP, Doyle BJ, Sohn VR, Bandipalliam P, Rozek LS, Reyes J, Cordero C, Balaguer F, Castells A, Jover R, Andreu M, Syngal S, Boland C, Llor X. Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology. 2010 May; 138(5):1854-62. PMID: 20102720; PMCID: PMC2859993.
      108. Boland C. A knockout for Lynch syndrome. Gastroenterology. 2010 Mar; 138(3):820-2. PMID: 20102757; PMCID: PMC2846619.
      109. Goel A, Boland C. Recent insights into the pathogenesis of colorectal cancer. Curr Opin Gastroenterol. 2010 Jan; 26(1):47-52. PMID: 19786869; PMCID: PMC2846600.
      110. Jung B, Gomez J, Chau E, Cabral J, Lee JK, Anselm A, Slowik P, Ream-Robinson D, Messer K, Sporn J, Shin SK, Boland C, Goel A, Carethers JM. Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms. PLoS One. 2009 Dec 14; 4(12):e8308. PMID: 20011542; PMCID: PMC2789408.
      111. Link A, Shin SK, Nagasaka T, Balaguer F, Koi M, Jung B, Boland C, Goel A. JC virus mediates invasion and migration in colorectal metastasis. PLoS One. 2009 Dec 03; 4(12):e8146. PMID: 19997600; PMCID: PMC2781631.
      112. Nagasaka T, Tanaka N, Cullings HM, Sun DS, Sasamoto H, Uchida T, Koi M, Nishida N, Naomoto Y, Boland C, Matsubara N, Goel A. Analysis of fecal DNA methylation to detect gastrointestinal neoplasia. J Natl Cancer Inst. 2009 Sep 16; 101(18):1244-58. PMID: 19700653; PMCID: PMC2762745.
      113. Giros A, Grzybowski M, Sohn VR, Pons E, Fernandez-Morales J, Xicola RM, Sethi P, Grzybowski J, Goel A, Boland C, Gassull MA, Llor X. Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. Cancer Prev Res (Phila). 2009 Aug; 2(8):732-42. PMID: 19638488; PMCID: PMC3793343.
      114. Yashiro M, Inoue T, Nishioka N, Matsuoka T, Boland C, Hirakawa K. Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma. Ann Surg Oncol. 2009 Oct; 16(10):2926-35. PMID: 19597886; PMCID: PMC2865194.
      115. Goel A, Mittal A, Evstatiev R, Nemeth M, Kruis W, Stolte M, Boland C, Gasche C. In vivo effects of mesalazine or E. coli Nissle 1917 on microsatellite instability in ulcerative colitis. Aliment Pharmacol Ther. 2009 Sep 15; 30(6):634-42. PMID: 19558562; PMCID: PMC2853877.
      116. Boland C, Shin SK, Goel A. Promoter methylation in the genesis of gastrointestinal cancer. Yonsei Med J. 2009 Jun 30; 50(3):309-21. PMID: 19568590; PMCID: PMC2703751.
      117. Vilkin A, Niv Y, Nagasaka T, Morgenstern S, Levi Z, Fireman Z, Fuerst F, Goel A, Boland C. Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel. Cancer. 2009 Feb 15; 115(4):760-9. PMID: 19127559; PMCID: PMC2855188.
      118. Boland C, Komarova NL, Goel A. Chromosomal instability and cancer: not just one CINgle mechanism. Gut. 2009 Feb; 58(2):163-4. PMID: 19136519; PMCID: PMC2858054.
      119. Haugen AC, Goel A, Yamada K, Marra G, Nguyen TP, Nagasaka T, Kanazawa S, Koike J, Kikuchi Y, Zhong X, Arita M, Shibuya K, Oshimura M, Hemmi H, Boland C, Koi M. Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. Cancer Res. 2008 Oct 15; 68(20):8465-72. PMID: 18922920; PMCID: PMC2678948.
      120. Selgrad M, Koornstra JJ, Fini L, Blom M, Huang R, Devol EB, Boersma-van Ek W, Dijkstra G, Verdonk RC, de Jong S, Goel A, Williams SL, Meyer RL, Haagsma EB, Ricciardiello L, Boland C. JC virus infection in colorectal neoplasia that develops after liver transplantation. Clin Cancer Res. 2008 Oct 15; 14(20):6717-21. PMID: 18927316; PMCID: PMC2846598.
      121. Arnold CN, Nagasaka T, Goel A, Scharf I, Grabowski P, Sosnowski A, Schmitt-Gräff A, Boland C, Arnold R, Blum HE. Molecular characteristics and predictors of survival in patients with malignant neuroendocrine tumors. Int J Cancer. 2008 Oct 01; 123(7):1556-64. PMID: 18646189; PMCID: PMC2851204.
      122. Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, Al-Mandhari M, Al-Mawaly K, Al-Mjeni R, Al-Sayegh A, Raeburn S, Lee E, Giardiello F, Smoot DT, Vilkin A, Boland C, Goel A, Hafezi M, Nouraie M, Ashktorab H. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer. 2008 Aug 21; 7:68. PMID: 18718023; PMCID: PMC2551625.
      123. Selgrad M, Malfertheiner P, Fini L, Goel A, Boland C, Ricciardiello L. The role of viral and bacterial pathogens in gastrointestinal cancer. J Cell Physiol. 2008 Aug; 216(2):378-88. PMID: 18338378; PMCID: PMC2855192.
      124. Boland C, Pasricha PJ, Sugano K. Preface. Gastrointestinal endoscopy has come a long way. Gastrointest Endosc Clin N Am. 2008 Jul; 18(3):xv-xvi. PMID: 18674692.
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      125. Selgrad M, De Giorgio R, Fini L, Cogliandro RF, Williams S, Stanghellini V, Barbara G, Tonini M, Corinaldesi R, Genta RM, Domiati-Saad R, Meyer R, Goel A, Boland C, Ricciardiello L. JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction. Gut. 2009 Jan; 58(1):25-32. PMID: 18593810; PMCID: PMC2865195.
      126. Nagasaka T, Goel A, Notohara K, Takahata T, Sasamoto H, Uchida T, Nishida N, Tanaka N, Boland C, Matsubara N. Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int J Cancer. 2008 Jun 01; 122(11):2429-36. PMID: 18240147; PMCID: PMC2851179.
      127. Nagasaka T, Koi M, Kloor M, Gebert J, Vilkin A, Nishida N, Shin SK, Sasamoto H, Tanaka N, Matsubara N, Boland C, Goel A. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology. 2008 Jun; 134(7):1950-60, 1960.e1. PMID: 18435933; PMCID: PMC2543132.
      128. Jung WT, Li MS, Goel A, Boland C. JC virus T-antigen expression in sporadic adenomatous polyps of the colon. Cancer. 2008 Mar 01; 112(5):1028-36. PMID: 18205186; PMCID: PMC2855201.
      129. Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland C, Goel A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology. 2008 Mar; 47(3):908-18. PMID: 18161048; PMCID: PMC2865182.
      130. Fini L, Selgrad M, Fogliano V, Graziani G, Romano M, Hotchkiss E, Daoud YA, De Vol EB, Boland C, Ricciardiello L. Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells. J Nutr. 2007 Dec; 137(12):2622-8. PMID: 18029474.
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      131. Fini L, Hotchkiss E, Fogliano V, Graziani G, Romano M, De Vol EB, Qin H, Selgrad M, Boland C, Ricciardiello L. Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. Carcinogenesis. 2008 Jan; 29(1):139-46. PMID: 17999988.
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      132. Boland C. Evaluation and management of Lynch syndrome. Clin Adv Hematol Oncol. 2007 Nov; 5(11):851,873. PMID: 18185481.
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      133. Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland C, Goel A. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology. 2007 Dec; 133(6):1849-57. PMID: 18054557; PMCID: PMC4139066.
      134. Lynch HT, Boland C, Rodriguez-Bigas MA, Amos C, Lynch JF, Lynch PM. Who should be sent for genetic testing in hereditary colorectal cancer syndromes? J Clin Oncol. 2007 Aug 10; 25(23):3534-42. PMID: 17687158.
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      135. Boland C, Koi M, Chang DK, Carethers JM. The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside. Fam Cancer. 2008; 7(1):41-52. PMID: 17636426; PMCID: PMC2847875.
      136. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Ajay G, Boland C. Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res. 2007 May 15; 67(10):4586-94. PMID: 17510384.
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      137. Nishida N, Nagasaka T, Kashiwagi K, Boland C, Goel A. High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. Cancer Biol Ther. 2007 Apr; 6(4):525-33. PMID: 17457043.
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      138. Boland C. Clinical uses of microsatellite instability testing in colorectal cancer: an ongoing challenge. J Clin Oncol. 2007 Mar 01; 25(7):754-6. PMID: 17228016.
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      139. Jascur T, Boland C. Structure and function of the components of the human DNA mismatch repair system. Int J Cancer. 2006 Nov 01; 119(9):2030-5. PMID: 16804905.
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      140. Goel A, Nagasaka T, Arnold CN, Inoue T, Hamilton C, Niedzwiecki D, Compton C, Mayer RJ, Goldberg R, Bertagnolli MM, Boland C. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroenterology. 2007 Jan; 132(1):127-38. PMID: 17087942.
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      141. Shin SK, Li MS, Fuerst F, Hotchkiss E, Meyer R, Kim IT, Goel A, Boland C. Oncogenic T-antigen of JC virus is present frequently in human gastric cancers. Cancer. 2006 Aug 01; 107(3):481-8. PMID: 16795066.
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      142. Anderson RD, Patel R, Hamilton JK, Boland C. Cronkhite-Canada syndrome presenting as eosinophilic gastroenteritis. Proc (Bayl Univ Med Cent). 2006 Jul; 19(3):209-12. PMID: 17252034; PMCID: PMC1484525.
      143. Boland C. Decoding hereditary colorectal cancer. N Engl J Med. 2006 Jun 29; 354(26):2815-7. PMID: 16807419.
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      144. Goel A, Li MS, Nagasaka T, Shin SK, Fuerst F, Ricciardiello L, Wasserman L, Boland C. Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers. Gastroenterology. 2006 Jun; 130(7):1950-61. PMID: 16762618.
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      145. Goel A, Fuerst F, Hotchkiss E, Boland C. Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells. Cancer Biol Ther. 2006 May; 5(5):529-35. PMID: 16627976.
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      146. Lynch HT, Boland C, Gong G, Shaw TG, Lynch PM, Fodde R, Lynch JF, de la Chapelle A. Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications. Eur J Hum Genet. 2006 Apr; 14(4):390-402. PMID: 16479259.
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      147. Boland C, Goel A. Somatic evolution of cancer cells. Semin Cancer Biol. 2005 Dec; 15(6):436-50. PMID: 16055343.
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      148. Arnold CN, Goel A, Blum HE, Boland C. Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis. Cancer. 2005 Nov 15; 104(10):2035-47. PMID: 16206296.
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      149. Ashktorab H, Smoot DT, Farzanmehr H, Fidelia-Lambert M, Momen B, Hylind L, Iacosozio-Dononue C, Carethers JM, Goel A, Boland C, Giardiello FM. Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. Int J Cancer. 2005 Oct 10; 116(6):914-9. PMID: 15856472; PMCID: PMC4155490.
      150. Ricciardiello L, Boland C. Lynch syndrome (hereditary non-polyposis colorectal cancer): current concepts and approaches to management. Curr Gastroenterol Rep. 2005 Oct; 7(5):412-20. PMID: 16168241.
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      151. Yashiro M, Laghi L, Saito K, Carethers JM, Slezak P, Rubio C, Hirakawa K, Boland C. Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps. Cancer Epidemiol Biomarkers Prev. 2005 Sep; 14(9):2253-6. PMID: 16172239.
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      152. Boland C, Luciani MG, Gasche C, Goel A. Infection, inflammation, and gastrointestinal cancer. Gut. 2005 Sep; 54(9):1321-31. PMID: 16099799; PMCID: PMC1774670.
      153. Boland C. Molecular screening for Lynch syndrome. Nat Clin Pract Gastroenterol Hepatol. 2005 Sep; 2(9):392-3. PMID: 16265427.
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      154. Goel A, Gasche C, Boland C. Chemoprevention goes gourmet: different flavors of NO-aspirin. Mol Interv. 2005 Aug; 5(4):207-10. PMID: 16123534.
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      155. Boland C, Fishel R. Lynch syndrome: form, function, proteins, and basketball. Gastroenterology. 2005 Aug; 129(2):751-5. PMID: 16083730.
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      156. Gasche C, Goel A, Natarajan L, Boland C. Mesalazine improves replication fidelity in cultured colorectal cells. Cancer Res. 2005 May 15; 65(10):3993-7. PMID: 15899787.
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      157. Niv Y, Goel A, Boland C. JC virus and colorectal cancer: a possible trigger in the chromosomal instability pathways. Curr Opin Gastroenterol. 2005 Jan; 21(1):85-9. PMID: 15687890.
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      158. Goel A, Arnold CN, Tassone P, Chang DK, Niedzwiecki D, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland C. Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. Int J Cancer. 2004 Dec 10; 112(5):754-9. PMID: 15386381.
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      159. Boland C, Bigler J, Newcomb PA, Lampe JW, Potter JD. Evidence for an association between JC virus and colorectal neoplasia. Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12):2285-6; author reply 2286. PMID: 15598796.
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      160. Laghi L, Randolph AE, Malesci A, Boland C. Constraints imposed by supercoiling on in vitro amplification of polyomavirus DNA. J Gen Virol. 2004 Nov; 85(Pt 11):3383-8. PMID: 15483255.
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      161. Arnold CN, Goel A, Niedzwiecki D, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland C. APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. Cancer Biol Ther. 2004 Oct; 3(10):960-4. PMID: 15326380.
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      162. Boland C. Clement Richard Boland, Jr., MD: a conversation with the editor. Interview by William Clifford Roberts. Proc (Bayl Univ Med Cent). 2004 Oct; 17(4):444-61. PMID: 16200134; PMCID: PMC1200686.
      163. Boland C. Understanding familial colorectal cancer-finding the corner pieces and filling in the center of the puzzle. Gastroenterology. 2004 Jul; 127(1):334-8. PMID: 15236204.
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      164. Boland C, Barrett KE. Posthumous presentation of the Julius M. Friedenwald medal to Jon I. Isenberg, M.D. Gastroenterology. 2004 Jun; 126(7):1884-9. PMID: 15188183.
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      165. Goel A, Arnold CN, Niedzwiecki D, Carethers JM, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland C. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res. 2004 May 01; 64(9):3014-21. PMID: 15126336.
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      166. Umar A, Boland C, Terdiman JP, Syngal S, de la Chapelle A, Rüschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R, Hamilton SR, Hiatt RA, Jass J, Lindblom A, Lynch HT, Peltomaki P, Ramsey SD, Rodriguez-Bigas MA, Vasen HF, Hawk ET, Barrett JC, Freedman AN, Srivastava S. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 2004 Feb 18; 96(4):261-8. PMID: 14970275; PMCID: PMC2933058.
      167. Carethers JM, Smith EJ, Behling CA, Nguyen L, Tajima A, Doctolero RT, Cabrera BL, Goel A, Arnold CA, Miyai K, Boland C. Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology. 2004 Feb; 126(2):394-401. PMID: 14762775.
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      168. Arnold CN, Goel A, Compton C, Marcus V, Niedzwiecki D, Dowell JM, Wasserman L, Inoue T, Mayer RJ, Bertagnolli MM, Boland C. Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer. Cancer Biol Ther. 2004 Jan; 3(1):73-8. PMID: 14726676.
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      169. Krishnan K, Aoki T, Ruffin MT, Normolle DP, Boland C, Brenner DE. Effects of low dose aspirin (81 mg) on proliferating cell nuclear antigen and Amaranthus caudatus labeling in normal-risk and high-risk human subjects for colorectal cancer. Cancer Detect Prev. 2004; 28(2):107-13. PMID: 15068834.
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      170. Boland C, Goel A. The silence of the genes: matching mismatch repair defects with tumors. Cancer. 2003 Nov 15; 98(10):2091-4. PMID: 14601077.
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      171. Ricciardiello L, Baglioni M, Giovannini C, Pariali M, Cenacchi G, Ripalti A, Landini MP, Sawa H, Nagashima K, Frisque RJ, Goel A, Boland C, Tognon M, Roda E, Bazzoli F. Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Cancer Res. 2003 Nov 01; 63(21):7256-62. PMID: 14612521.
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      172. Arnold CN, Goel A, Boland C. Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines. Int J Cancer. 2003 Aug 10; 106(1):66-73. PMID: 12794758.
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      173. Boland C, Demarco DC. Invited commentary: Preventing colon cancer: looking over the horizon. Proc (Bayl Univ Med Cent). 2003 Jul; 16(3):344-5. PMID: 16278707; PMCID: PMC1200790.
      174. Tassone P, Tagliaferri P, Viscomi C, Palmieri C, Caraglia M, D'Alessandro A, Galea E, Goel A, Abbruzzese A, Boland C, Venuta S. Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br J Cancer. 2003 Jun 16; 88(12):1971-8. PMID: 12799645; PMCID: PMC2741108.
      175. Chang DK, Goel A, Ricciardiello L, Lee DH, Chang CL, Carethers JM, Boland C. Effect of H(2)O(2) on cell cycle and survival in DNA mismatch repair-deficient and -proficient cell lines. Cancer Lett. 2003 Jun 10; 195(2):243-51. PMID: 12767533.
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      176. Tassone P, Tagliaferri P, Perricelli A, Blotta S, Quaresima B, Martelli ML, Goel A, Barbieri V, Costanzo F, Boland C, Venuta S. BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. Br J Cancer. 2003 Apr 22; 88(8):1285-91. PMID: 12698198; PMCID: PMC2747554.
      177. Goel A, Arnold CN, Niedzwiecki D, Chang DK, Ricciardiello L, Carethers JM, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland C. Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res. 2003 Apr 01; 63(7):1608-14. PMID: 12670912.
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      178. Lee SH, Chang DK, Goel A, Boland C, Bugbee W, Boyle DL, Firestein GS. Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis. J Immunol. 2003 Feb 15; 170(4):2214-20. PMID: 12574395.
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      179. Ricciardiello L, Goel A, Mantovani V, Fiorini T, Fossi S, Chang DK, Lunedei V, Pozzato P, Zagari RM, De Luca L, Fuccio L, Martinelli GN, Roda E, Boland C, Bazzoli F. Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer. Cancer Res. 2003 Feb 15; 63(4):787-92. PMID: 12591727.
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      180. Gasche C, Chang CL, Natarajan L, Goel A, Rhees J, Young DJ, Arnold CN, Boland C. Identification of frame-shift intermediate mutant cells. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1914-9. PMID: 12578960; PMCID: PMC149933.
      181. Boland C, Goel A. A rat virus visits the clinic: translating basic discoveries into clinical medicine in the 21st century. Gut. 2003 Jan; 52(1):8-9. PMID: 12477748; PMCID: PMC1773531.
      182. Goel A, Chang DK, Ricciardiello L, Gasche C, Boland C. A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells. Clin Cancer Res. 2003 Jan; 9(1):383-90. PMID: 12538492.
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      183. Shadan FF, Cunningham C, Boland C. JC virus: a biomarker for colorectal cancer? Med Hypotheses. 2002 Dec; 59(6):667-9. PMID: 12445507.
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      184. Magrini R, Bhonde MR, Hanski ML, Notter M, Scherübl H, Boland C, Zeitz M, Hanski C. Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status. Int J Cancer. 2002 Sep 01; 101(1):23-31. PMID: 12209584.
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      185. Chang CL, Marra G, Chauhan DP, Ha HT, Chang DK, Ricciardiello L, Randolph A, Carethers JM, Boland C. Oxidative stress inactivates the human DNA mismatch repair system. Am J Physiol Cell Physiol. 2002 Jul; 283(1):C148-54. PMID: 12055083.
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      186. Laghi L, Orbetegli O, Bianchi P, Zerbi A, Di Carlo V, Boland C, Malesci A. Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers. Oncogene. 2002 Jun 20; 21(27):4301-6. PMID: 12082617.
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      187. Boland C. Molecular basis for stool-based DNA tests for colorectal cancer: a primer for clinicians. Rev Gastroenterol Disord. 2002; 2 Suppl 1:S12-9. PMID: 12439394.
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      188. Goel A, Arnold CN, Boland C. Multistep progression of colorectal cancer in the setting of microsatellite instability: new details and novel insights. Gastroenterology. 2001 Dec; 121(6):1497-502. PMID: 11729129.
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      189. Goel A, Boland C, Chauhan DP. Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett. 2001 Oct 30; 172(2):111-8. PMID: 11566484.
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      190. Gasche C, Chang CL, Rhees J, Goel A, Boland C. Oxidative stress increases frameshift mutations in human colorectal cancer cells. Cancer Res. 2001 Oct 15; 61(20):7444-8. PMID: 11606378.
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      191. Chang DK, Metzgar D, Wills C, Boland C. Microsatellites in the eukaryotic DNA mismatch repair genes as modulators of evolutionary mutation rate. Genome Res. 2001 Jul; 11(7):1145-6. PMID: 11435395.
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      192. Huang SC, Lavine JE, Boland PS, Newbury RO, Kolodner R, Pham TT, Arnold CN, Boland C, Carethers JM. Germline characterization of early-aged onset of hereditary non-polyposis colorectal cancer. J Pediatr. 2001 May; 138(5):629-35. PMID: 11343035.
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      193. Krishnan K, Ruffin MT, Normolle D, Shureiqi I, Burney K, Bailey J, Peters-Golden M, Rock CL, Boland C, Brenner DE. Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2001 May; 10(5):447-53. PMID: 11352853.
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      194. Boland C, Yamada T. American Gastroenterological Association. Our new president--Jon I. Isenberg, M.D. Gastroenterology. 2001 May; 120(6):1518-21. PMID: 11313322.
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      195. Boland C, Savides TJ. The changing scope of colorectal cancer. Gut. 2001 Apr; 48(4):449-50. PMID: 11288733; PMCID: PMC1728258.
      196. Yashiro M, Carethers JM, Laghi L, Saito K, Slezak P, Jaramillo E, Rubio C, Koizumi K, Hirakawa K, Boland C. Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res. 2001 Mar 15; 61(6):2676-83. PMID: 11289147.
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      197. Ricciardiello L, Chang DK, Laghi L, Goel A, Chang CL, Boland C. Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissues. J Virol. 2001 Feb; 75(4):1996-2001. PMID: 11160700; PMCID: PMC115147.
      198. Müller W, Burgart LJ, Krause-Paulus R, Thibodeau SN, Almeida M, Edmonston TB, Boland C, Sutter C, Jass JR, Lindblom A, Lubinski J, MacDermot K, Sanders DS, Morreau H, Müller A, Oliani C, Orntoft T, Ponz De Leon M, Rosty C, Rodriguez-Bigas M, Rüschoff J, Ruszkiewicz A, Sabourin J, Salovaara R, Möslein G. The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC)--results of an international collaborative study. Fam Cancer. 2001; 1(2):87-92. PMID: 14574003.
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      199. Ricciardiello L, Laghi L, Ramamirtham P, Chang CL, Chang DK, Randolph AE, Boland C. JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract. Gastroenterology. 2000 Nov; 119(5):1228-35. PMID: 11054380.
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      200. Chauhan DP, Yang Q, Carethers JM, Marra G, Chang CL, Chamberlain SM, Boland C. Antisense inhibition of hMLH1 is not sufficient for loss of DNA mismatch repair function in the HCT116+chromosome 3 cell line. Clin Cancer Res. 2000 Oct; 6(10):3827-31. PMID: 11051225.
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      201. Chang DK, Ricciardiello L, Goel A, Chang CL, Boland C. Steady-state regulation of the human DNA mismatch repair system. J Biol Chem. 2000 Jun 16; 275(24):18424-31. PMID: 10747992.
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      202. Boland C. Molecular genetics of hereditary nonpolyposis colorectal cancer. Ann N Y Acad Sci. 2000 Jun; 910:50-9; discussion 59-61. PMID: 10911905.
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      203. Yan H, Papadopoulos N, Marra G, Perrera C, Jiricny J, Boland C, Lynch HT, Chadwick RB, de la Chapelle A, Berg K, Eshleman JR, Yuan W, Markowitz S, Laken SJ, Lengauer C, Kinzler KW, Vogelstein B. Conversion of diploidy to haploidy. Nature. 2000 Feb 17; 403(6771):723-4. PMID: 10693791.
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      204. Boland C, Sinicrope FA, Brenner DE, Carethers JM. Colorectal cancer prevention and treatment. Gastroenterology. 2000 Feb; 118(2 Suppl 1):S115-28. PMID: 10868902.
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      205. Boland C, Ricciardiello L. How many mutations does it take to make a tumor? Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14675-7. PMID: 10611270; PMCID: PMC33954.
      206. Carethers JM, Chauhan DP, Fink D, Nebel S, Bresalier RS, Howell SB, Boland C. Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology. 1999 Jul; 117(1):123-31. PMID: 10381918; PMCID: PMC4343206.
      207. Laghi L, Randolph AE, Chauhan DP, Marra G, Major EO, Neel JV, Boland C. JC virus DNA is present in the mucosa of the human colon and in colorectal cancers. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7484-9. PMID: 10377441; PMCID: PMC22112.
      208. Boland C, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN, Srivastava S. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998 Nov 15; 58(22):5248-57. PMID: 9823339.
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      209. Foss FM, Raubitscheck A, Mulshine JL, Fleisher TA, Reynolds JC, Paik CH, Neumann RD, Boland C, Perentesis P, Brown MR, Frincke JM, Lollo CP, Larson SM, Carrasquillo JA. Phase I study of the pharmacokinetics of a radioimmunoconjugate, 90Y-T101, in patients with CD5-expressing leukemia and lymphoma. Clin Cancer Res. 1998 Nov; 4(11):2691-700. PMID: 9829731.
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      210. Macdonald GA, Greenson JK, Saito K, Cherian SP, Appelman HD, Boland C. Microsatellite instability and loss of heterozygosity at DNA mismatch repair gene loci occurs during hepatic carcinogenesis. Hepatology. 1998 Jul; 28(1):90-7. PMID: 9657101.
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      211. Carethers JM, Furnari FB, Zigman AF, Lavine JE, Jones MC, Graham GE, Teebi AS, Huang HJ, Ha HT, Chauhan DP, Chang CL, Cavenee WK, Boland C. Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome. Cancer Res. 1998 Jul 01; 58(13):2724-6. PMID: 9661881.
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      212. Carethers JM, Hawn MT, Greenson JK, Hitchcock CL, Boland C. Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. Gastroenterology. 1998 Jun; 114(6):1188-95. PMID: 9609755.
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      213. Davis TW, Wilson-Van Patten C, Meyers M, Kunugi KA, Cuthill S, Reznikoff C, Garces C, Boland C, Kinsella TJ, Fishel R, Boothman DA. Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. Cancer Res. 1998 Feb 15; 58(4):767-78. PMID: 9485033.
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      214. Boland C, Sato J, Saito K, Carethers JM, Marra G, Laghi L, Chauhan DP. Genetic instability and chromosomal aberrations in colorectal cancer: a review of the current models. Cancer Detect Prev. 1998; 22(5):377-82. PMID: 9727618.
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      215. Rodriguez-Bigas MA, Boland C, Hamilton SR, Henson DE, Jass JR, Khan PM, Lynch H, Perucho M, Smyrk T, Sobin L, Srivastava S. A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst. 1997 Dec 03; 89(23):1758-62. PMID: 9392616.
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      216. Boland C. Genetic pathways to colorectal cancer. Hosp Pract (1995). 1997 Nov 15; 32(11):79-84, 87-96. PMID: 9385315.
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      217. Zigman AF, Lavine JE, Jones MC, Boland C, Carethers JM. Localization of the Bannayan-Riley-Ruvalcaba syndrome gene to chromosome 10q23. Gastroenterology. 1997 Nov; 113(5):1433-7. PMID: 9352843.
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      218. Umar A, Koi M, Risinger JI, Glaab WE, Tindall KR, Kolodner RD, Boland C, Barrett JC, Kunkel TA. Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res. 1997 Sep 15; 57(18):3949-55. PMID: 9307278.
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      219. Ruffin MT, Krishnan K, Rock CL, Normolle D, Vaerten MA, Peters-Golden M, Crowell J, Kelloff G, Boland C, Brenner DE. Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose. J Natl Cancer Inst. 1997 Aug 06; 89(15):1152-60. PMID: 9262254.
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      220. Binnie CG, Kam-Morgan LN, Cayouette MC, Marra G, Boland C, Luce M. Rapid identification of RT-PCR clones containing translation-terminating mutations. Mutat Res. 1997 Jan 15; 388(1):21-6. PMID: 9025788.
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      221. Marra G, Boland C. DNA repair and colorectal cancer. Gastroenterol Clin North Am. 1996 Dec; 25(4):755-72. PMID: 8960891.
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      222. Marra G, Chang CL, Laghi LA, Chauhan DP, Young D, Boland C. Expression of human MutS homolog 2 (hMSH2) protein in resting and proliferating cells. Oncogene. 1996 Nov 21; 13(10):2189-96. PMID: 8950986.
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      223. Lee PJ, Washer LL, Law DJ, Boland C, Horon IL, Feinberg AP. Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10366-70. PMID: 8816806; PMCID: PMC38390.
      224. Boland C. Setting microsatellites free. Nat Med. 1996 Sep; 2(9):972-4. PMID: 8782450.
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      225. Aebi S, Kurdi-Haidar B, Gordon R, Cenni B, Zheng H, Fink D, Christen RD, Boland C, Koi M, Fishel R, Howell SB. Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res. 1996 Jul 01; 56(13):3087-90. PMID: 8674066.
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      226. Carethers JM, Hawn MT, Chauhan DP, Luce MC, Marra G, Koi M, Boland C. Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine. J Clin Invest. 1996 Jul 01; 98(1):199-206. PMID: 8690794; PMCID: PMC507417.
      227. LaRusso NF, Phillips SF, Bloomer JR, Boland C, Chang EB, DiMagno EP, Giannella RA, Gores GJ, Malagelada JR, Miller LJ, Rakela J, Szurszewski JH, Binder HJ, Clain JE, LaMont JT, Link AM. Passing the torch: a look back at our editorship. Gastroenterology. 1996 May; 110(5):1336-8. PMID: 8613036.
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      228. Romano M, Lesch CA, Meise KS, Veljaca M, Sanchez B, Kraus ER, Boland C, Guglietta A, Coffey RJ. Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats. Gastroenterology. 1996 May; 110(5):1448-55. PMID: 8613050.
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      229. Mellon I, Rajpal DK, Koi M, Boland C, Champe GN. Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science. 1996 Apr 26; 272(5261):557-60. PMID: 8614807.
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      230. Brentnall TA, Crispin DA, Bronner MP, Cherian SP, Hueffed M, Rabinovitch PS, Rubin CE, Haggitt RC, Boland C. Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res. 1996 Mar 15; 56(6):1237-40. PMID: 8640805.
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      231. Boland C. Roles of the DNA mismatch repair genes in colorectal tumorigenesis. Int J Cancer. 1996 Feb 20; 69(1):47-9. PMID: 8600059.
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      232. Yoshimura K, Delbarre SG, Kraus E, Boland C. The effects of omeprazole and famotidine on mucin and PGE2 release in the rat stomach. Aliment Pharmacol Ther. 1996 Feb; 10(1):111-7. PMID: 8871451.
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      233. Hawn MT, Umar A, Carethers JM, Marra G, Kunkel TA, Boland C, Koi M. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res. 1995 Sep 01; 55(17):3721-5. PMID: 7641183.
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      234. Boland C, Sato J, Appelman HD, Bresalier RS, Feinberg AP. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat Med. 1995 Sep; 1(9):902-9. PMID: 7585215.
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      235. Marra G, Boland C. Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J Natl Cancer Inst. 1995 Aug 02; 87(15):1114-25. PMID: 7674315.
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      236. Koi M, Umar A, Chauhan DP, Cherian SP, Carethers JM, Kunkel TA, Boland C. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 1994 Aug 15; 54(16):4308-12. PMID: 8044777.
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      237. Chen YF, Boland C, Kraus ER, Goldstein IJ. The lectin Griffonia simplicifolia I-A4 (GS I-A4) specifically recognizes terminal alpha-linked N-acetylgalactosaminyl groups and is cytotoxic to the human colon cancer cell lines LS174t and SW1116. Int J Cancer. 1994 May 15; 57(4):561-7. PMID: 7514154.
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      238. Niv Y, Boland C, Kim YS. Increased tumorigenicity after differentiation of colon cancer cell line: absence of association with mucin synthesis. Gastroenterology. 1994 Feb; 106(2):389-98. PMID: 8299906.
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      239. Boland C. The biology of colorectal cancer. Implications for pretreatment and follow-up management. Cancer. 1993 Jun 15; 71(12 Suppl):4180-6. PMID: 8508377.
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      240. Lynch HT, Smyrk TC, Watson P, Lanspa SJ, Lynch JF, Lynch PM, Cavalieri RJ, Boland C. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology. 1993 May; 104(5):1535-49. PMID: 8482467.
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      241. Romano M, Polk WH, Awad JA, Arteaga CL, Nanney LB, Wargovich MJ, Kraus ER, Boland C, Coffey RJ. Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo. J Clin Invest. 1992 Dec; 90(6):2409-21. PMID: 1281834; PMCID: PMC443397.
      242. Scheiman JM, Kraus ER, Boland C. Regulation of canine gastric mucin synthesis and phospholipid secretion by acid secretagogues. Gastroenterology. 1992 Dec; 103(6):1842-50. PMID: 1333428.
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      243. Boland C, Kolars JC. Fiber and colon cancer: the weight of the evidence. Gastroenterology. 1992 Dec; 103(6):1964-7. PMID: 1333430.
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      244. Scheiman JM, Kraus ER, Yoshimura K, Boland C. Effect of sucralfate on components of mucosal barrier produced by cultured canine epithelial cells in vitro. Dig Dis Sci. 1992 Dec; 37(12):1853-9. PMID: 1473434.
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      245. Feinberg AP, Johnson LA, Law DJ, Kuehn SE, Steenman M, Williams BR, Thomas G, Boland C, Rainier S, Koi M. Multiple tumor suppressor genes in multistep carcinogenesis. Tohoku J Exp Med. 1992 Oct; 168(2):149-52. PMID: 1339099.
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      246. Lynch HT, Watson P, Smyrk TC, Lanspa SJ, Boman BM, Boland C, Lynch JF, Cavalieri RJ, Leppert M, White R. Colon cancer genetics. Cancer. 1992 Sep 01; 70(5 Suppl):1300-12. PMID: 1511377.
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      247. Yoshimura K, Kraus ER, Shimakura S, Scheiman JM, Boland C. Role of prostaglandin E2 in cholinergic-mediated glycoprotein synthesis in canine antrum. Dig Dis Sci. 1992 Jul; 37(7):1045-50. PMID: 1618052.
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      248. Shimakura S, Boland C. Eicosanoid production by the human gastric cancer cell line AGS and its relation to cell growth. Cancer Res. 1992 Apr 01; 52(7):1744-9. PMID: 1551103.
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      249. Scheiman JM, Kraus ER, Bonnville LA, Weinhold PA, Boland C. Synthesis and prostaglandin E2-induced secretion of surfactant phospholipid by isolated gastric mucous cells. Gastroenterology. 1991 May; 100(5 Pt 1):1232-40. PMID: 1707384.
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      250. Boland C, Chen YF, Rinderle SJ, Resau JH, Luk GD, Lynch HT, Goldstein IJ. Use of the lectin from Amaranthus caudatus as a histochemical probe of proliferating colonic epithelial cells. Cancer Res. 1991 Jan 15; 51(2):657-65. PMID: 1985783.
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      251. Sams JS, Lynch HT, Burt RW, Lanspa SJ, Boland C. Abnormalities of lectin histochemistry in familial polyposis coli and hereditary nonpolyposis colorectal cancer. Cancer. 1990 Aug 01; 66(3):502-8. PMID: 2194645.
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      252. Boland C, Deshmukh GD. The carbohydrate composition of mucin in colonic cancer. Gastroenterology. 1990 May; 98(5 Pt 1):1170-7. PMID: 2323510.
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      253. Boland C, Kraus ER, Scheiman JM, Black C, Deshmukh GD, Dobbins WO. Characterization of mucous cell synthetic functions in a new primary canine gastric mucous cell culture system. Am J Physiol. 1990 May; 258(5 Pt 1):G774-87. PMID: 2334003.
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      254. Boland C, Roberts JA. Quantitation of lectin binding sites in human colon mucins by use of peanut and wheat germ agglutinins. J Histochem Cytochem. 1988 Oct; 36(10):1305-7. PMID: 3138307.
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      255. Boland C, Bresalier RS, Roberts JA. Assay of lectin binding sites in colon cancer-associated mucins: comparison of fluorescence microscopy with a quantitative chromatographic technique. J Histochem Cytochem. 1988 Oct; 36(10):1329-34. PMID: 3138308.
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      256. Shimamoto C, Weinstein WM, Boland C. Glycoconjugate expression in normal, metaplastic, and neoplastic human upper gastrointestinal mucosa. J Clin Invest. 1987 Dec; 80(6):1670-8. PMID: 3680520; PMCID: PMC442438.
      257. Boland C, Kim YS. Transitional mucosa of the colon and tumor growth factors. Med Hypotheses. 1987 Mar; 22(3):237-43. PMID: 3473277.
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      258. Boland C, Clapp NK. Glycoconjugates in the colons of New World monkeys with spontaneous colitis. Association between inflammation and neoplasia. Gastroenterology. 1987 Mar; 92(3):625-34. PMID: 3102306.
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