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Clement Boland

Title(s)Adjunct Professor, Medicine
SchoolHealth Sciences
Phone858-249-0772
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    Collapse Biography 
    Collapse Education and Training
    UCSF, San Francisco, CAGI Fellowship1981GI Cancer Research
    Yale Univ School of Medicine, New Haven, CTMD1973Medicine
    Univ of Notre Dame, South Bend, INBA1969Liberal Arts
    Collapse Awards and Honors
    Univ of Michigan2017  - presC. Richard Boland Distinguished Professorship
    AGA2016Friedenwald Medal
    Collaborative Group of the Americas2015Lifetime Achievement Award
    AGA2015Beaumont Prize in Gastroenterology
    AGA2011  - 2012President
    AGA Oncology Section2001Distinguished Mentor Award
    AAP2001  - presElected Member
    AGA1992  - 1993Funderburg Award

    Collapse Research 
    Collapse Research Activities and Funding
    Investing in the Future to Promote Diversity in GI Training
    NIH/NIDDK R25DK096968Sep 10, 2012 - Aug 31, 2017
    Role: Principal Investigator
    JC Virus and Human Colorectal Neoplasia
    NIH/NCI R01CA098572Dec 1, 2002 - Jan 31, 2015
    Role: Principal Investigator
    Familial and Early Onset Colorectal Cancer
    NIH/NCI R01CA072851May 10, 1996 - Jul 31, 2020
    Role: Co-Principal Investigator
    MUCIN FAMILIES IN THE GASTROINTESTINAL TRACT
    NIH/NCI R55CA039233Sep 30, 1993 - Jun 30, 1994
    Role: Principal Investigator
    C/EBP BETA IN HEPATOCYTE GENE EXPRESSION &PROLIFERATION
    NIH/NIDDK R01DK046971Jul 15, 1993 - Aug 31, 2003
    Role: Co-Principal Investigator
    REGULATION OF GASTRIC MUCIN SYNTHESIS
    NIH/NIDDK R01DK037989May 1, 1988 - Apr 30, 1992
    Role: Principal Investigator
    MUCIN FAMILIES IN GASTROINTESTINAL TRACT
    NIH/NCI R01CA039233Aug 1, 1981 - Apr 30, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jansen AML, Ghosh P, Dakal TC, Slavin TP, Boland CR, Goel A. Novel candidates in early-onset familial colorectal cancer. Fam Cancer. 2019 Sep 25. PMID: 31555933.
      View in: PubMed
    2. Boland CR. Henry T. Lynch, MD (January 4, 1928-June 2, 2019). Gastroenterology. 2019 10; 157(4):905-906. PMID: 31477523.
      View in: PubMed
    3. Dwyer AJ, Murphy CC, Boland CR, Garcia R, Hampel H, Limburg P, Lowery J, Zauber AG, Waring S, Worrall S, Perea J, Siegel R, Lee J, Molmenti C, Sears CL, Buckhaults P, Hayes R, Hussan H, de Miranda N, Palles C, Diaz L, Song M, Cercek A, Lieu CH, Patel SG, Karlitz JJ, Cao Y, Demb J, Blatchford P, Risendal B, Weltzien E, Wali A, Daschner P, Loomans-Kropp H, Flores R, Levell CL, Wehling K, Martin J, Pesmen C, Kuchar V, Soisson R, Davis A, Ahnen D. A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer. Gastroenterology. 2019 08; 157(2):280-288. PMID: 31095950.
      View in: PubMed
    4. Strum WB, Boland CR. Clinical and Genetic Characteristics of Colorectal Cancer in Persons under 50 Years of Age: A Review. Dig Dis Sci. 2019 May 04. PMID: 31055721.
      View in: PubMed
    5. Antelo M, Golubicki M, Roca E, Mendez G, Carballido M, Iseas S, Cuatrecasas M, Moreira L, Sanchez A, Carballal S, Castells A, Boland CR, Goel A, Balaguer F. Lynch-like syndrome is as frequent as Lynch syndrome in early-onset nonfamilial nonpolyposis colorectal cancer. Int J Cancer. 2019 Aug 01; 145(3):705-713. PMID: 30693488.
      View in: PubMed
    6. Conner BR, Hernandez F, Souders B, Landrith T, Boland CR, Karam R. RNA Analysis Identifies Pathogenic Duplications in MSH2 in Patients With Lynch Syndrome. Gastroenterology. 2019 05; 156(6):1924-1925.e4. PMID: 30710526.
      View in: PubMed
    7. Strum WB, Boland CR. Characterization and Identification of Colorectal Cancer in Persons Younger Than 50 Years. Clin Gastroenterol Hepatol. 2018 Dec 10. PMID: 30543950.
      View in: PubMed
    8. Pathak SJ, Mueller JL, Okamoto K, Das B, Hertecant J, Greenhalgh L, Cole T, Pinsk V, Yerushalmi B, Gurkan OE, Yourshaw M, Hernandez E, Oesterreicher S, Naik S, Sanderson IR, Axelsson I, Agardh D, Boland CR, Martin MG, Putnam CD, Sivagnanam M. EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome. Hum Mutat. 2019 Feb; 40(2):142-161. PMID: 30461124.
      View in: PubMed
    9. Toiyama Y, Okugawa Y, Boland CR, Goel A. Reply. Gastroenterology. 2018 06; 154(8):2274-2275. PMID: 29750909.
      View in: PubMed
    10. Murcia O, Jover R, Egoavil C, Perez-Carbonell L, Juárez M, Hernández-Illán E, Rojas E, Alenda C, Balaguer F, Andreu M, Llor X, Castells A, Boland CR, Goel A. TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer. Clin Cancer Res. 2018 06 15; 24(12):2820-2827. PMID: 29535127.
      View in: PubMed
    11. Clark LA, Ghazi A, Gaffney K, Soto R, Agarwal A, Carmack S, Boland CR. Diagnosis of Malignant Potential in Mucinous Peritoneal Neoplasms by Characterization of Mucin Carbohydrate Structure. Cell Mol Gastroenterol Hepatol. 2018; 6(1):108-109.e2. PMID: 29928675.
      View in: PubMed
    12. Boland PM, Yurgelun MB, Boland CR. Recent progress in Lynch syndrome and other familial colorectal cancer syndromes. CA Cancer J Clin. 2018 05; 68(3):217-231. PMID: 29485237.
      View in: PubMed
    13. Takehara Y, Nagasaka T, Nyuya A, Haruma T, Haraga J, Mori Y, Nakamura K, Fujiwara T, Boland CR, Goel A. Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors. J Transl Med. 2018 01 12; 16(1):5. PMID: 29329588.
      View in: PubMed
    14. Yamada A, Yu P, Lin W, Okugawa Y, Boland CR, Goel A. A RNA-Sequencing approach for the identification of novel long non-coding RNA biomarkers in colorectal cancer. Sci Rep. 2018 01 12; 8(1):575. PMID: 29330370.
      View in: PubMed
    15. Boland CR. Erratum to: Non-coding RNA: It's Not Junk. Dig Dis Sci. 2017 11; 62(11):3260. PMID: 28879425.
      View in: PubMed
    16. Wodarz D, Goel A, Boland CR, Komarova NL. Effect of aspirin on tumour cell colony formation and evolution. J R Soc Interface. 2017 09; 14(134). PMID: 28878032.
      View in: PubMed
    17. Toiyama Y, Okugawa Y, Tanaka K, Araki T, Uchida K, Hishida A, Uchino M, Ikeuchi H, Hirota S, Kusunoki M, Boland CR, Goel A. A Panel of Methylated MicroRNA Biomarkers for Identifying High-Risk Patients With Ulcerative Colitis-Associated Colorectal Cancer. Gastroenterology. 2017 12; 153(6):1634-1646.e8. PMID: 28847750.
      View in: PubMed
    18. Boland CR, Yurgelun MB. Mutational cascades in cancer. Oncotarget. 2017 Jun 27; 8(26):41784-41785. PMID: 28620150.
      View in: PubMed
    19. Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ. Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017 07; 153(1):307-323. PMID: 28600072.
      View in: PubMed
    20. Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ. Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer. Gastrointest Endosc. 2017 07; 86(1):18-33. PMID: 28600070.
      View in: PubMed
    21. Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ. Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2017 Jul; 112(7):1016-1030. PMID: 28555630.
      View in: PubMed
    22. Richard Boland C. Non-coding RNA: It's Not Junk. Dig Dis Sci. 2017 05; 62(5):1107-1109. PMID: 28271304.
      View in: PubMed
    23. Durno C, Boland CR, Cohen S, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ, Rex DK. Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-society Task Force on Colorectal Cancer. J Pediatr Gastroenterol Nutr. 2017 05; 64(5):836-843. PMID: 28353469.
      View in: PubMed
    24. Durno C, Boland CR, Cohen S, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ, Rex DK. Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2017 05; 112(5):682-690. PMID: 28349994.
      View in: PubMed
    25. Durno C, Boland CR, Cohen S, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ, Rex DK. Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017 05; 152(6):1605-1614. PMID: 28363489.
      View in: PubMed
    26. Durno C, Boland CR, Cohen S, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ, Rex DK. Recommendations on surveillance and management of biallelic mismatch repair deficiency (BMMRD) syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer. Gastrointest Endosc. 2017 05; 85(5):873-882. PMID: 28363411.
      View in: PubMed
    27. Boland CR, Yurgelun MB. Historical Perspective on Familial Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2017 Mar; 3(2):192-200. PMID: 28275686.
      View in: PubMed
    28. Zumwalt TJ, Wodarz D, Komarova NL, Toden S, Turner J, Cardenas J, Burn J, Chan AT, Boland CR, Goel A. Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells. Cancer Prev Res (Phila). 2017 Mar; 10(3):208-218. PMID: 28154202.
      View in: PubMed
    29. Shia J, Schultz N, Kuk D, Vakiani E, Middha S, Segal NH, Hechtman JF, Berger MF, Stadler ZK, Weiser MR, Wolchok JD, Boland CR, Gönen M, Klimstra DS. Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications. Mod Pathol. 2017 04; 30(4):599-609. PMID: 27982025.
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    30. Yurgelun MB, Boland CR. "New" Cancer Genes and Inherited Colorectal Cancer Risk: Caveat Emptor. Gastroenterology. 2017 01; 152(1):12-13. PMID: 27889571.
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    31. Robertson DJ, Lee JK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Rex DK. Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017 04; 152(5):1217-1237.e3. PMID: 27769517.
      View in: PubMed
    32. Robertson DJ, Lee JK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Rex DK. Recommendations on fecal immunochemical testing to screen for colorectal neoplasia: a consensus statement by the US Multi-Society Task Force on colorectal cancer. Gastrointest Endosc. 2017 Jan; 85(1):2-21.e3. PMID: 27769516.
      View in: PubMed
    33. Robertson DJ, Lee JK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Rex DK. Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2017 01; 112(1):37-53. PMID: 27753435.
      View in: PubMed
    34. Shigeyasu K, Okugawa Y, Toden S, Boland CR, Goel A. Exportin-5 Functions as an Oncogene and a Potential Therapeutic Target in Colorectal Cancer. Clin Cancer Res. 2017 Mar 01; 23(5):1312-1322. PMID: 27553833.
      View in: PubMed
    35. Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F, Bhattacharyya A, Hsu CH, Chow HH, Ahnen DJ, Boland CR, Heigh RI, Fay DE, Hamilton SR, Jacobs ET, Martinez ME, Alberts DS, Lance P. Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes. J Natl Cancer Inst. 2016 12; 108(12). PMID: 27530657.
      View in: PubMed
    36. Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F, Bhattacharyya A, Hsu CH, Chow SH, Ahnen DJ, Boland CR, Heigh RI, Fay DE, Hamilton SR, Jacobs ET, Martinez EM, Alberts DS, Lance P. Celecoxib for the Prevention of Colorectal Adenomas: Results of a Suspended Randomized Controlled Trial. J Natl Cancer Inst. 2016 12; 108(12). PMID: 27530656.
      View in: PubMed
    37. Boland CR. Recent discoveries in the molecular genetics of Lynch syndrome. Fam Cancer. 2016 07; 15(3):395-403. PMID: 27038793.
      View in: PubMed
    38. Lowery JT, Ahnen DJ, Schroy PC, Hampel H, Baxter N, Boland CR, Burt RW, Butterly L, Doerr M, Doroshenk M, Feero WG, Henrikson N, Ladabaum U, Lieberman D, McFarland EG, Peterson SK, Raymond M, Samadder NJ, Syngal S, Weber TK, Zauber AG, Smith R. Understanding the contribution of family history to colorectal cancer risk and its clinical implications: A state-of-the-science review. Cancer. 2016 09 01; 122(17):2633-45. PMID: 27258162.
      View in: PubMed
    39. Moreno-Ortiz JM, Ayala-Madrigal Mde L, Corona-Rivera JR, Centeno-Flores M, Maciel-Gutiérrez V, Franco-Topete RA, Armendáriz-Borunda J, Hotchkiss E, Pérez-Carbonell L, Rhees J, Boland CR, Gutiérrez-Angulo M. Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome. Gastroenterol Res Pract. 2016; 2016:5278024. PMID: 27247567.
      View in: PubMed
    40. Kahi CJ, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Robertson DJ, Rex DK. Colonoscopy Surveillance after Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2016 Mar; 111(3):337-46; quiz 347. PMID: 26871541.
      View in: PubMed
    41. Kahi CJ, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Robertson DJ, Rex DK. Colonoscopy Surveillance After Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2016 Mar; 150(3):758-768.e11. PMID: 26892199.
      View in: PubMed
    42. Boland CR, Goel A. Prognostic Subgroups among Patients with Stage II Colon Cancer. N Engl J Med. 2016 Jan 21; 374(3):277-8. PMID: 26789877.
      View in: PubMed
    43. Kahi CJ, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Robertson DJ, Rex DK. Colonoscopy surveillance after colorectal cancer resection: recommendations of the US multi-society task force on colorectal cancer. Gastrointest Endosc. 2016 Mar; 83(3):489-98.e10. PMID: 26802191.
      View in: PubMed
    44. Koi M, Garcia M, Choi C, Kim HR, Koike J, Hemmi H, Nagasaka T, Okugawa Y, Toiyama Y, Kitajima T, Imaoka H, Kusunoki M, Chen YH, Mukherjee B, Boland CR, Carethers JM. Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis. Gastroenterology. 2016 Apr; 150(4):944-55. PMID: 26752111.
      View in: PubMed
    45. Hur K, Toiyama Y, Okugawa Y, Ide S, Imaoka H, Boland CR, Goel A. Circulating microRNA-203 predicts prognosis and metastasis in human colorectal cancer. Gut. 2017 04; 66(4):654-665. PMID: 26701878.
      View in: PubMed
    46. Okugawa Y, Toiyama Y, Toden S, Mitoma H, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A. Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer. Gut. 2017 01; 66(1):107-117. PMID: 26475630.
      View in: PubMed
    47. Antelo M, Milito D, Rhees J, Roca E, Barugel M, Cuatrecasas M, Moreira L, Leoz ML, Carballal S, Ocaña T, Pellisé M, Castells A, Boland CR, Goel A, Balaguer F. Pitfalls in the diagnosis of biallelic PMS2 mutations. Fam Cancer. 2015 Sep; 14(3):411-4. PMID: 25773960.
      View in: PubMed
    48. Stoffel EM, Boland CR. Genetics and Genetic Testing in Hereditary Colorectal Cancer. Gastroenterology. 2015 Oct; 149(5):1191-1203.e2. PMID: 26226567.
      View in: PubMed
    49. Yamada A, Horimatsu T, Okugawa Y, Nishida N, Honjo H, Ida H, Kou T, Kusaka T, Sasaki Y, Yagi M, Higurashi T, Yukawa N, Amanuma Y, Kikuchi O, Muto M, Ueno Y, Nakajima A, Chiba T, Boland CR, Goel A. Serum miR-21, miR-29a, and miR-125b Are Promising Biomarkers for the Early Detection of Colorectal Neoplasia. Clin Cancer Res. 2015 Sep 15; 21(18):4234-42. PMID: 26038573.
      View in: PubMed
    50. Perez-Carbonell L, Sinicrope FA, Alberts SR, Oberg AL, Balaguer F, Castells A, Boland CR, Goel A. MiR-320e is a novel prognostic biomarker in colorectal cancer. Br J Cancer. 2015 Jun 30; 113(1):83-90. PMID: 26035698.
      View in: PubMed
    51. Lamba AR, Moore AY, Moore T, Rhees J, Arnold MA, Boland CR. Defective DNA mismatch repair activity is common in sebaceous neoplasms, and may be an ineffective approach to screen for Lynch syndrome. Fam Cancer. 2015 Jun; 14(2):259-64. PMID: 25637498.
      View in: PubMed
    52. Wei C, Peng B, Han Y, Chen WV, Rother J, Tomlinson GE, Boland CR, Chaussabel D, Chaussabel M, Frazier ML, Amos CI. Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers. Fam Cancer. 2015 Jun; 14(2):297-306. PMID: 25716654.
      View in: PubMed
    53. Goodenberger ML, Thomas BC, Riegert-Johnson D, Boland CR, Plon SE, Clendenning M, Win AK, Senter L, Lipkin SM, Stadler ZK, Macrae FA, Lynch HT, Weitzel JN, de la Chapelle A, Syngal S, Lynch P, Parry S, Jenkins MA, Gallinger S, Holter S, Aronson M, Newcomb PA, Burnett T, Le Marchand L, Pichurin P, Hampel H, Terdiman JP, Lu KH, Thibodeau S, Lindor NM. PMS2 monoallelic mutation carriers: the known unknown. Genet Med. 2016 Jan; 18(1):13-9. PMID: 25856668.
      View in: PubMed
    54. Shia J, Stadler ZK, Weiser MR, Vakiani E, Mendelsohn R, Markowitz AJ, Shike M, Boland CR, Klimstra DS. Mismatch repair deficient-crypts in non-neoplastic colonic mucosa in Lynch syndrome: insights from an illustrative case. Fam Cancer. 2015 Mar; 14(1):61-8. PMID: 25173403.
      View in: PubMed
    55. Toden S, Okugawa Y, Buhrmann C, Nattamai D, Anguiano E, Baldwin N, Shakibaei M, Boland CR, Goel A. Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. Cancer Prev Res (Phila). 2015 May; 8(5):431-43. PMID: 25712055.
      View in: PubMed
    56. Zumwalt TJ, Arnold M, Goel A, Boland CR. Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration. Oncotarget. 2015 Feb 20; 6(5):2981-91. PMID: 25671296.
      View in: PubMed
    57. Hur K, Toiyama Y, Schetter AJ, Okugawa Y, Harris CC, Boland CR, Goel A. Identification of a metastasis-specific MicroRNA signature in human colorectal cancer. J Natl Cancer Inst. 2015 Mar; 107(3). PMID: 25663689.
      View in: PubMed
    58. Toden S, Okugawa Y, Jascur T, Wodarz D, Komarova NL, Buhrmann C, Shakibaei M, Boland CR, Goel A. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis. 2015 Mar; 36(3):355-67. PMID: 25653233.
      View in: PubMed
    59. Moreira L, Muñoz J, Cuatrecasas M, Quintanilla I, Leoz ML, Carballal S, Ocaña T, López-Cerón M, Pellise M, Castellví-Bel S, Jover R, Andreu M, Carracedo A, Xicola RM, Llor X, Boland CR, Goel A, Castells A, Balaguer F. Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancer. Cancer. 2015 May 01; 121(9):1395-404. PMID: 25557234.
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    60. Yamada A, Cox MA, Gaffney KA, Moreland A, Boland CR, Goel A. Technical factors involved in the measurement of circulating microRNA biomarkers for the detection of colorectal neoplasia. PLoS One. 2014; 9(11):e112481. PMID: 25405754.
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    61. Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland CR, Goel A. Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis. 2014 Dec; 35(12):2731-9. PMID: 25280565.
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    62. Johnson DA, Barkun AN, Cohen LB, Dominitz JA, Kaltenbach T, Martel M, Robertson DJ, Boland CR, Giardello FM, Lieberman DA, Levin TR, Rex DK. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the U.S. multi-society task force on colorectal cancer. Gastrointest Endosc. 2014 Oct; 80(4):543-562. PMID: 25220509.
      View in: PubMed
    63. Johnson DA, Barkun AN, Cohen LB, Dominitz JA, Kaltenbach T, Martel M, Robertson DJ, Boland CR, Giardello FM, Lieberman DA, Levin TR, Rex DK. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer. Gastroenterology. 2014 Oct; 147(4):903-24. PMID: 25239068.
      View in: PubMed
    64. Perez-Carbonell L, Balaguer F, Toiyama Y, Egoavil C, Rojas E, Guarinos C, Andreu M, Llor X, Castells A, Jover R, Boland CR, Goel A. IGFBP3 methylation is a novel diagnostic and predictive biomarker in colorectal cancer. PLoS One. 2014; 9(8):e104285. PMID: 25127039.
      View in: PubMed
    65. Giardiello FM, Allen JI, Axilbund JE, Boland CR, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer. Gastroenterology. 2014 Aug; 147(2):502-26. PMID: 25043945.
      View in: PubMed
    66. Giardiello FM, Allen JI, Axilbund JE, Boland CR, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the U.S. Multi-Society Task Force on Colorectal Cancer. Gastrointest Endosc. 2014 Aug; 80(2):197-220. PMID: 25034835.
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    67. Giardiello FM, Allen JI, Axilbund JE, Boland CR, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer. Dis Colon Rectum. 2014 Aug; 57(8):1025-48. PMID: 25003300.
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    68. Giardiello FM, Allen JI, Axilbund JE, Boland CR, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer. Am J Gastroenterol. 2014 Aug; 109(8):1159-79. PMID: 25070057.
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    69. Butcher LD, Garcia M, Arnold M, Ueno H, Goel A, Boland CR. Immune response to JC virus T antigen in patients with and without colorectal neoplasia. Gut Microbes. 2014 Jul 01; 5(4):468-75. PMID: 25007286.
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    70. Link A, Balaguer F, Nagasaka T, Boland CR, Goel A. MicroRNA miR-J1-5p as a potential biomarker for JC virus infection in the gastrointestinal tract. PLoS One. 2014; 9(6):e100036. PMID: 24932487.
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    71. Rhees J, Arnold M, Boland CR. Inversion of exons 1-7 of the MSH2 gene is a frequent cause of unexplained Lynch syndrome in one local population. Fam Cancer. 2014 Jun; 13(2):219-25. PMID: 24114314.
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    72. Yamada A, Minamiguchi S, Sakai Y, Horimatsu T, Muto M, Chiba T, Boland CR, Goel A. Colorectal advanced neoplasms occur through dual carcinogenesis pathways in individuals with coexisting serrated polyps. PLoS One. 2014; 9(5):e98059. PMID: 24849572.
      View in: PubMed
    73. Toiyama Y, Hur K, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A. Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancer. Ann Surg. 2014 Apr; 259(4):735-43. PMID: 23982750.
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    74. Toiyama Y, Boland CR, Goel A. Response. J Natl Cancer Inst. 2014 Mar; 106(3):djt458. PMID: 24586104.
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    75. Wodarz D, Boland CR, Goel A, Komarova NL. Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines. Biol Direct. 2013 Jun 11; 8:14. PMID: 23758948.
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    76. Toiyama Y, Takahashi M, Hur K, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A. Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst. 2013 Jun 19; 105(12):849-59. PMID: 23704278.
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    77. Hur K, Cejas P, Feliu J, Moreno-Rubio J, Burgos E, Boland CR, Goel A. Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. Gut. 2014 Apr; 63(4):635-46. PMID: 23704319.
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    78. Piazzi G, Selgrad M, Garcia M, Ceccarelli C, Fini L, Bianchi P, Laghi L, D'Angelo L, Paterini P, Malfertheiner P, Chieco P, Boland CR, Bazzoli F, Ricciardiello L. Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers. Br J Cancer. 2013 Apr 30; 108(8):1750-6. PMID: 23579212.
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    79. Boland CR. The mystery of mismatch repair deficiency: lynch or lynch-like? Gastroenterology. 2013 May; 144(5):868-70. PMID: 23523847.
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    80. Link A, Balaguer F, Shen Y, Lozano JJ, Leung HC, Boland CR, Goel A. Curcumin modulates DNA methylation in colorectal cancer cells. PLoS One. 2013; 8(2):e57709. PMID: 23460897.
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    81. Shah KR, Boland CR, Patel M, Thrash B, Menter A. Cutaneous manifestations of gastrointestinal disease: part I. J Am Acad Dermatol. 2013 Feb; 68(2):189.e1-21; quiz 210. PMID: 23317980.
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    82. Thrash B, Patel M, Shah KR, Boland CR, Menter A. Cutaneous manifestations of gastrointestinal disease: part II. J Am Acad Dermatol. 2013 Feb; 68(2):211.e1-33; quiz 244-6. PMID: 23317981.
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    83. Thompson P, Roe DJ, Fales L, Buckmeier J, Wang F, Hamilton SR, Bhattacharyya A, Green S, Hsu CH, Chow HH, Ahnen DJ, Boland CR, Heigh RI, Fay DE, Martinez ME, Jacobs E, Ashbeck EL, Alberts DS, Lance P. Design and baseline characteristics of participants in a phase III randomized trial of celecoxib and selenium for colorectal adenoma prevention. Cancer Prev Res (Phila). 2012 Dec; 5(12):1381-93. PMID: 23060037.
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    84. Takahashi M, Cuatrecasas M, Balaguer F, Hur K, Toiyama Y, Castells A, Boland CR, Goel A. The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer. PLoS One. 2012; 7(10):e46684. PMID: 23056401.
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    85. Williams JC, Hamilton JK, Shiller M, Fischer L, Deprisco G, Boland CR. Combined juvenile polyposis and hereditary hemorrhagic telangiectasia. Proc (Bayl Univ Med Cent). 2012 Oct; 25(4):360-4. PMID: 23077388.
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    86. Antelo M, Balaguer F, Shia J, Shen Y, Hur K, Moreira L, Cuatrecasas M, Bujanda L, Giraldez MD, Takahashi M, Cabanne A, Barugel ME, Arnold M, Roca EL, Andreu M, Castellvi-Bel S, Llor X, Jover R, Castells A, Boland CR, Goel A. A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer. PLoS One. 2012; 7(9):e45357. PMID: 23049789.
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    87. Goel A, Boland CR. Epigenetics of colorectal cancer. Gastroenterology. 2012 Dec; 143(6):1442-1460.e1. PMID: 23000599.
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    88. Takahashi M, Sung B, Shen Y, Hur K, Link A, Boland CR, Aggarwal BB, Goel A. Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family. Carcinogenesis. 2012 Dec; 33(12):2441-9. PMID: 22983985.
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    89. Shia J, Zhang L, Shike M, Guo M, Stadler Z, Xiong X, Tang LH, Vakiani E, Katabi N, Wang H, Bacares R, Ruggeri J, Boland CR, Ladanyi M, Klimstra DS. Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency. Mod Pathol. 2013 Jan; 26(1):131-8. PMID: 22918162.
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    90. Boland CR, Krejs G, Emmett M, Richardson C. A birthday celebration for John S. Fordtran, MD. Proc (Bayl Univ Med Cent). 2012 Jul; 25(3):250-3. PMID: 22754128.
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    91. Hur K, Toiyama Y, Takahashi M, Balaguer F, Nagasaka T, Koike J, Hemmi H, Koi M, Boland CR, Goel A. MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut. 2013 Sep; 62(9):1315-26. PMID: 22735571.
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    92. Shen Y, Takahashi M, Byun HM, Link A, Sharma N, Balaguer F, Leung HC, Boland CR, Goel A. Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells. Cancer Biol Ther. 2012 May; 13(7):542-52. PMID: 22415137.
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    93. Boland CR. Lynch syndrome: new tales from the crypt. Lancet Oncol. 2012 Jun; 13(6):562-4. PMID: 22552010.
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    94. Garcia M, Choi C, Kim HR, Daoud Y, Toiyama Y, Takahashi M, Goel A, Boland CR, Koi M. Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability. Gastroenterology. 2012 Jul; 143(1):48-50.e1. PMID: 22465427.
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    95. Kathiria AS, Butcher LD, Feagins LA, Souza RF, Boland CR, Theiss AL. Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. PLoS One. 2012; 7(2):e31231. PMID: 22363587.
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    96. Li J, Koike J, Kugoh H, Arita M, Ohhira T, Kikuchi Y, Funahashi K, Takamatsu K, Boland CR, Koi M, Hemmi H. Down-regulation of MutS homolog 3 by hypoxia in human colorectal cancer. Biochim Biophys Acta. 2012 Apr; 1823(4):889-99. PMID: 22343000.
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    97. Yurgelun MB, Goel A, Hornick JL, Sen A, Turgeon DK, Ruffin MT, Marcon NE, Baron JA, Bresalier RS, Syngal S, Brenner DE, Boland CR, Stoffel EM. Microsatellite instability and DNA mismatch repair protein deficiency in Lynch syndrome colorectal polyps. Cancer Prev Res (Phila). 2012 Apr; 5(4):574-82. PMID: 22262812.
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    98. Piazzi G, Fini L, Selgrad M, Garcia M, Daoud Y, Wex T, Malfertheiner P, Gasbarrini A, Romano M, Meyer RL, Genta RM, Fox JG, Boland CR, Bazzoli F, Ricciardiello L. Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer. Oncotarget. 2011 Dec; 2(12):1291-301. PMID: 22249198.
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    99. Balaguer F, Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M, Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover R, Llor X, Castells A, Boland CR, Gironella M, Goel A. Colorectal cancers with microsatellite instability display unique miRNA profiles. Clin Cancer Res. 2011 Oct 01; 17(19):6239-49. PMID: 21844009.
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    100. Ladabaum U, Wang G, Terdiman J, Blanco A, Kuppermann M, Boland CR, Ford J, Elkin E, Phillips KA. Strategies to identify the Lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis. Ann Intern Med. 2011 Jul 19; 155(2):69-79. PMID: 21768580.
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    101. Lynch HT, Riegert-Johnson DL, Snyder C, Lynch JF, Hagenkord J, Boland CR, Rhees J, Thibodeau SN, Boardman LA, Davies J, Kuiper RP, Hoogerbrugge N, Ligtenberg MJ. Lynch syndrome-associated extracolonic tumors are rare in two extended families with the same EPCAM deletion. Am J Gastroenterol. 2011 Oct; 106(10):1829-36. PMID: 21769135.
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    102. Jascur T, Fotedar R, Greene S, Hotchkiss E, Boland CR. N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1. J Biol Chem. 2011 Aug 26; 286(34):29531-9. PMID: 21725088.
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    103. Fini L, Piazzi G, Daoud Y, Selgrad M, Maegawa S, Garcia M, Fogliano V, Romano M, Graziani G, Vitaglione P, Carmack SW, Gasbarrini A, Genta RM, Issa JP, Boland CR, Ricciardiello L. Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract. Cancer Prev Res (Phila). 2011 Jun; 4(6):907-15. PMID: 21383028.
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    104. Goel A, Nguyen TP, Leung HC, Nagasaka T, Rhees J, Hotchkiss E, Arnold M, Banerji P, Koi M, Kwok CT, Packham D, Lipton L, Boland CR, Ward RL, Hitchins MP. De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one. Int J Cancer. 2011 Feb 15; 128(4):869-78. PMID: 20473912.
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    105. Takahashi M, Koi M, Balaguer F, Boland CR, Goel A. MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin, and a poly(ADP-ribose) polymerase inhibitor. J Biol Chem. 2011 Apr 08; 286(14):12157-65. PMID: 21285347.
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    106. Koi M, Boland CR. Tumor hypoxia and genetic alterations in sporadic cancers. J Obstet Gynaecol Res. 2011 Feb; 37(2):85-98. PMID: 21272156.
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    107. Gasche JA, Hoffmann J, Boland CR, Goel A. Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells. Int J Cancer. 2011 Sep 01; 129(5):1053-63. PMID: 21710491.
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    108. Boland CR. Speed kills. Clin Gastroenterol Hepatol. 2011 Apr; 9(4):290-2. PMID: 21195793.
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    109. Jover R, Nguyen TP, Pérez-Carbonell L, Zapater P, Payá A, Alenda C, Rojas E, Cubiella J, Balaguer F, Morillas JD, Clofent J, Bujanda L, Reñé JM, Bessa X, Xicola RM, Nicolás-Pérez D, Castells A, Andreu M, Llor X, Boland CR, Goel A. 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer. Gastroenterology. 2011 Apr; 140(4):1174-81. PMID: 21185836.
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    110. Ramamoorthy S, Devaraj B, Miyai K, Luo L, Liu YT, Boland CR, Goel A, Carethers JM. John Cunningham virus T-antigen expression in anal carcinoma. Cancer. 2011 Jun 01; 117(11):2379-85. PMID: 24048785.
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    111. Dinh TA, Rosner BI, Atwood JC, Boland CR, Syngal S, Vasen HF, Gruber SB, Burt RW. Health benefits and cost-effectiveness of primary genetic screening for Lynch syndrome in the general population. Cancer Prev Res (Phila). 2011 Jan; 4(1):9-22. PMID: 21088223.
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    112. Boland CR. Chronic inflammation, colorectal cancer and gene polymorphisms. Dig Dis. 2010; 28(4-5):590-5. PMID: 21088407.
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    113. Gupta S, Ashfaq R, Kapur P, Afonso BB, Nguyen TP, Ansari F, Boland CR, Goel A, Rockey DC. Microsatellite instability among individuals of Hispanic origin with colorectal cancer. Cancer. 2010 Nov 01; 116(21):4965-72. PMID: 20665498.
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    114. Fini L, Piazzi G, Ceccarelli C, Daoud Y, Belluzzi A, Munarini A, Graziani G, Fogliano V, Selgrad M, Garcia M, Gasbarrini A, Genta RM, Boland CR, Ricciardiello L. Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in Apc(Min/+) mice. Clin Cancer Res. 2010 Dec 01; 16(23):5703-11. PMID: 21030497.
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    115. Giráldez MD, Balaguer F, Bujanda L, Cuatrecasas M, Muñoz J, Alonso-Espinaco V, Larzabal M, Petit A, Gonzalo V, Ocaña T, Moreira L, Enríquez-Navascués JM, Boland CR, Goel A, Castells A, Castellví-Bel S. MSH6 and MUTYH deficiency is a frequent event in early-onset colorectal cancer. Clin Cancer Res. 2010 Nov 15; 16(22):5402-13. PMID: 20924129.
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    116. Balaguer F, Link A, Lozano JJ, Cuatrecasas M, Nagasaka T, Boland CR, Goel A. Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis. Cancer Res. 2010 Aug 15; 70(16):6609-18. PMID: 20682795.
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    117. Goel A, Nagasaka T, Spiegel J, Meyer R, Lichliter WE, Boland CR. Low frequency of Lynch syndrome among young patients with non-familial colorectal cancer. Clin Gastroenterol Hepatol. 2010 Nov; 8(11):966-71. PMID: 20655395.
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    118. Boland CR, Goel A. Clearing the air on smoking and colorectal cancer. J Natl Cancer Inst. 2010 Jul 21; 102(14):996-7. PMID: 20587791.
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    119. Yashiro M, Hirakawa K, Boland CR. Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability. BMC Cancer. 2010 Jun 18; 10:303. PMID: 20565851.
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    120. Link A, Balaguer F, Shen Y, Nagasaka T, Lozano JJ, Boland CR, Goel A. Fecal MicroRNAs as novel biomarkers for colon cancer screening. Cancer Epidemiol Biomarkers Prev. 2010 Jul; 19(7):1766-74. PMID: 20551304.
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    121. Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010 Jun; 138(6):2073-2087.e3. PMID: 20420947.
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    122. Campregher C, Scharl T, Nemeth M, Honeder C, Jascur T, Boland CR, Gasche C. The nucleotide composition of microsatellites impacts both replication fidelity and mismatch repair in human colorectal cells. Hum Mol Genet. 2010 Jul 01; 19(13):2648-57. PMID: 20421367.
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    123. Boland CR, Shike M. Report from the Jerusalem workshop on Lynch syndrome-hereditary nonpolyposis colorectal cancer. Gastroenterology. 2010 Jun; 138(7):2197.e1-7. PMID: 20416305.
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    124. Nagasaka T, Rhees J, Kloor M, Gebert J, Naomoto Y, Boland CR, Goel A. Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers. Cancer Res. 2010 Apr 15; 70(8):3098-108. PMID: 20388775.
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    125. Goel A, Nagasaka T, Hamelin R, Boland CR. An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers. PLoS One. 2010 Feb 24; 5(2):e9393. PMID: 20195377.
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    126. Yamada K, Kanazawa S, Koike J, Sugiyama H, Xu C, Funahashi K, Boland CR, Koi M, Hemmi H. Microsatellite instability at tetranucleotide repeats in sporadic colorectal cancer in Japan. Oncol Rep. 2010 Feb; 23(2):551-61. PMID: 20043121.
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    127. Goel A, Xicola RM, Nguyen TP, Doyle BJ, Sohn VR, Bandipalliam P, Rozek LS, Reyes J, Cordero C, Balaguer F, Castells A, Jover R, Andreu M, Syngal S, Boland CR, Llor X. Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology. 2010 May; 138(5):1854-62. PMID: 20102720.
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    128. Boland CR. A knockout for Lynch syndrome. Gastroenterology. 2010 Mar; 138(3):820-2. PMID: 20102757.
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    129. Goel A, Boland CR. Recent insights into the pathogenesis of colorectal cancer. Curr Opin Gastroenterol. 2010 Jan; 26(1):47-52. PMID: 19786869.
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    130. Jung B, Gomez J, Chau E, Cabral J, Lee JK, Anselm A, Slowik P, Ream-Robinson D, Messer K, Sporn J, Shin SK, Boland CR, Goel A, Carethers JM. Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms. PLoS One. 2009 Dec 14; 4(12):e8308. PMID: 20011542.
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    131. Link A, Shin SK, Nagasaka T, Balaguer F, Koi M, Jung B, Boland CR, Goel A. JC virus mediates invasion and migration in colorectal metastasis. PLoS One. 2009 Dec 03; 4(12):e8146. PMID: 19997600.
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    132. Nagasaka T, Tanaka N, Cullings HM, Sun DS, Sasamoto H, Uchida T, Koi M, Nishida N, Naomoto Y, Boland CR, Matsubara N, Goel A. Analysis of fecal DNA methylation to detect gastrointestinal neoplasia. J Natl Cancer Inst. 2009 Sep 16; 101(18):1244-58. PMID: 19700653.
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    133. Giros A, Grzybowski M, Sohn VR, Pons E, Fernandez-Morales J, Xicola RM, Sethi P, Grzybowski J, Goel A, Boland CR, Gassull MA, Llor X. Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. Cancer Prev Res (Phila). 2009 Aug; 2(8):732-42. PMID: 19638488.
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    134. Yashiro M, Inoue T, Nishioka N, Matsuoka T, Boland CR, Hirakawa K. Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma. Ann Surg Oncol. 2009 Oct; 16(10):2926-35. PMID: 19597886.
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    135. Goel A, Mittal A, Evstatiev R, Nemeth M, Kruis W, Stolte M, Boland CR, Gasche C. In vivo effects of mesalazine or E. coli Nissle 1917 on microsatellite instability in ulcerative colitis. Aliment Pharmacol Ther. 2009 Sep 15; 30(6):634-42. PMID: 19558562.
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    136. Boland CR, Shin SK, Goel A. Promoter methylation in the genesis of gastrointestinal cancer. Yonsei Med J. 2009 Jun 30; 50(3):309-21. PMID: 19568590.
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    137. Vilkin A, Niv Y, Nagasaka T, Morgenstern S, Levi Z, Fireman Z, Fuerst F, Goel A, Boland CR. Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel. Cancer. 2009 Feb 15; 115(4):760-9. PMID: 19127559.
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    138. Boland CR, Komarova NL, Goel A. Chromosomal instability and cancer: not just one CINgle mechanism. Gut. 2009 Feb; 58(2):163-4. PMID: 19136519.
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    139. Selgrad M, Koornstra JJ, Fini L, Blom M, Huang R, Devol EB, Boersma-van Ek W, Dijkstra G, Verdonk RC, de Jong S, Goel A, Williams SL, Meyer RL, Haagsma EB, Ricciardiello L, Boland CR. JC virus infection in colorectal neoplasia that develops after liver transplantation. Clin Cancer Res. 2008 Oct 15; 14(20):6717-21. PMID: 18927316.
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    140. Haugen AC, Goel A, Yamada K, Marra G, Nguyen TP, Nagasaka T, Kanazawa S, Koike J, Kikuchi Y, Zhong X, Arita M, Shibuya K, Oshimura M, Hemmi H, Boland CR, Koi M. Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. Cancer Res. 2008 Oct 15; 68(20):8465-72. PMID: 18922920.
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    141. Arnold CN, Nagasaka T, Goel A, Scharf I, Grabowski P, Sosnowski A, Schmitt-Gräff A, Boland CR, Arnold R, Blum HE. Molecular characteristics and predictors of survival in patients with malignant neuroendocrine tumors. Int J Cancer. 2008 Oct 01; 123(7):1556-64. PMID: 18646189.
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    142. Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, Al-Mandhari M, Al-Mawaly K, Al-Mjeni R, Al-Sayegh A, Raeburn S, Lee E, Giardiello F, Smoot DT, Vilkin A, Boland CR, Goel A, Hafezi M, Nouraie M, Ashktorab H. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer. 2008 Aug 21; 7:68. PMID: 18718023.
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    143. Selgrad M, Malfertheiner P, Fini L, Goel A, Boland CR, Ricciardiello L. The role of viral and bacterial pathogens in gastrointestinal cancer. J Cell Physiol. 2008 Aug; 216(2):378-88. PMID: 18338378.
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    144. Boland CR, Pasricha PJ, Sugano K. Preface. Gastrointestinal endoscopy has come a long way. Gastrointest Endosc Clin N Am. 2008 Jul; 18(3):xv-xvi. PMID: 18674692.
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    145. Selgrad M, De Giorgio R, Fini L, Cogliandro RF, Williams S, Stanghellini V, Barbara G, Tonini M, Corinaldesi R, Genta RM, Domiati-Saad R, Meyer R, Goel A, Boland CR, Ricciardiello L. JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction. Gut. 2009 Jan; 58(1):25-32. PMID: 18593810.
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    146. Nagasaka T, Goel A, Notohara K, Takahata T, Sasamoto H, Uchida T, Nishida N, Tanaka N, Boland CR, Matsubara N. Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int J Cancer. 2008 Jun 01; 122(11):2429-36. PMID: 18240147.
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    147. Nagasaka T, Koi M, Kloor M, Gebert J, Vilkin A, Nishida N, Shin SK, Sasamoto H, Tanaka N, Matsubara N, Boland CR, Goel A. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology. 2008 Jun; 134(7):1950-60, 1960.e1. PMID: 18435933.
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    148. Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology. 2008 Mar; 47(3):908-18. PMID: 18161048.
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    149. Jung WT, Li MS, Goel A, Boland CR. JC virus T-antigen expression in sporadic adenomatous polyps of the colon. Cancer. 2008 Mar 01; 112(5):1028-36. PMID: 18205186.
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    150. Fini L, Selgrad M, Fogliano V, Graziani G, Romano M, Hotchkiss E, Daoud YA, De Vol EB, Boland CR, Ricciardiello L. Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells. J Nutr. 2007 Dec; 137(12):2622-8. PMID: 18029474.
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    151. Fini L, Hotchkiss E, Fogliano V, Graziani G, Romano M, De Vol EB, Qin H, Selgrad M, Boland CR, Ricciardiello L. Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. Carcinogenesis. 2008 Jan; 29(1):139-46. PMID: 17999988.
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    152. Boland CR. Evaluation and management of Lynch syndrome. Clin Adv Hematol Oncol. 2007 Nov; 5(11):851,873. PMID: 18185481.
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    153. Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR, Goel A. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology. 2007 Dec; 133(6):1849-57. PMID: 18054557.
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    154. Lynch HT, Boland CR, Rodriguez-Bigas MA, Amos C, Lynch JF, Lynch PM. Who should be sent for genetic testing in hereditary colorectal cancer syndromes? J Clin Oncol. 2007 Aug 10; 25(23):3534-42. PMID: 17687158.
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    155. Boland CR, Koi M, Chang DK, Carethers JM. The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside. Fam Cancer. 2008; 7(1):41-52. PMID: 17636426.
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    156. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Ajay G, Boland CR. Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res. 2007 May 15; 67(10):4586-94. PMID: 17510384.
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    157. Nishida N, Nagasaka T, Kashiwagi K, Boland CR, Goel A. High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. Cancer Biol Ther. 2007 Apr; 6(4):525-33. PMID: 17457043.
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    158. Boland CR. Clinical uses of microsatellite instability testing in colorectal cancer: an ongoing challenge. J Clin Oncol. 2007 Mar 01; 25(7):754-6. PMID: 17228016.
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    159. Jascur T, Boland CR. Structure and function of the components of the human DNA mismatch repair system. Int J Cancer. 2006 Nov 01; 119(9):2030-5. PMID: 16804905.
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    160. Goel A, Nagasaka T, Arnold CN, Inoue T, Hamilton C, Niedzwiecki D, Compton C, Mayer RJ, Goldberg R, Bertagnolli MM, Boland CR. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroenterology. 2007 Jan; 132(1):127-38. PMID: 17087942.
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    161. Shin SK, Li MS, Fuerst F, Hotchkiss E, Meyer R, Kim IT, Goel A, Boland CR. Oncogenic T-antigen of JC virus is present frequently in human gastric cancers. Cancer. 2006 Aug 01; 107(3):481-8. PMID: 16795066.
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    162. Anderson RD, Patel R, Hamilton JK, Boland CR. Cronkhite-Canada syndrome presenting as eosinophilic gastroenteritis. Proc (Bayl Univ Med Cent). 2006 Jul; 19(3):209-12. PMID: 17252034.
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    163. Boland CR. Decoding hereditary colorectal cancer. N Engl J Med. 2006 Jun 29; 354(26):2815-7. PMID: 16807419.
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    164. Goel A, Li MS, Nagasaka T, Shin SK, Fuerst F, Ricciardiello L, Wasserman L, Boland CR. Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers. Gastroenterology. 2006 Jun; 130(7):1950-61. PMID: 16762618.
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    165. Goel A, Fuerst F, Hotchkiss E, Boland CR. Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells. Cancer Biol Ther. 2006 May; 5(5):529-35. PMID: 16627976.
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    166. Lynch HT, Boland CR, Gong G, Shaw TG, Lynch PM, Fodde R, Lynch JF, de la Chapelle A. Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications. Eur J Hum Genet. 2006 Apr; 14(4):390-402. PMID: 16479259.
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    167. Boland CR, Goel A. Somatic evolution of cancer cells. Semin Cancer Biol. 2005 Dec; 15(6):436-50. PMID: 16055343.
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    168. Arnold CN, Goel A, Blum HE, Boland CR. Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis. Cancer. 2005 Nov 15; 104(10):2035-47. PMID: 16206296.
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    169. Ashktorab H, Smoot DT, Farzanmehr H, Fidelia-Lambert M, Momen B, Hylind L, Iacosozio-Dononue C, Carethers JM, Goel A, Boland CR, Giardiello FM. Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. Int J Cancer. 2005 Oct 10; 116(6):914-9. PMID: 15856472.
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    170. Ricciardiello L, Boland CR. Lynch syndrome (hereditary non-polyposis colorectal cancer): current concepts and approaches to management. Curr Gastroenterol Rep. 2005 Oct; 7(5):412-20. PMID: 16168241.
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    171. Yashiro M, Laghi L, Saito K, Carethers JM, Slezak P, Rubio C, Hirakawa K, Boland CR. Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps. Cancer Epidemiol Biomarkers Prev. 2005 Sep; 14(9):2253-6. PMID: 16172239.
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    172. Boland CR. Molecular screening for Lynch syndrome. Nat Clin Pract Gastroenterol Hepatol. 2005 Sep; 2(9):392-3. PMID: 16265427.
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    173. Boland CR, Luciani MG, Gasche C, Goel A. Infection, inflammation, and gastrointestinal cancer. Gut. 2005 Sep; 54(9):1321-31. PMID: 16099799.
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    174. Goel A, Gasche C, Boland CR. Chemoprevention goes gourmet: different flavors of NO-aspirin. Mol Interv. 2005 Aug; 5(4):207-10. PMID: 16123534.
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    175. Boland CR, Fishel R. Lynch syndrome: form, function, proteins, and basketball. Gastroenterology. 2005 Aug; 129(2):751-5. PMID: 16083730.
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    176. Gasche C, Goel A, Natarajan L, Boland CR. Mesalazine improves replication fidelity in cultured colorectal cells. Cancer Res. 2005 May 15; 65(10):3993-7. PMID: 15899787.
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    177. Niv Y, Goel A, Boland CR. JC virus and colorectal cancer: a possible trigger in the chromosomal instability pathways. Curr Opin Gastroenterol. 2005 Jan; 21(1):85-9. PMID: 15687890.
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    178. Goel A, Arnold CN, Tassone P, Chang DK, Niedzwiecki D, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR. Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. Int J Cancer. 2004 Dec 10; 112(5):754-9. PMID: 15386381.
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    179. Boland CR, Bigler J, Newcomb PA, Lampe JW, Potter JD. Evidence for an association between JC virus and colorectal neoplasia. Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12):2285-6; author reply 2286. PMID: 15598796.
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    180. Laghi L, Randolph AE, Malesci A, Boland CR. Constraints imposed by supercoiling on in vitro amplification of polyomavirus DNA. J Gen Virol. 2004 Nov; 85(Pt 11):3383-8. PMID: 15483255.
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    181. Arnold CN, Goel A, Niedzwiecki D, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR. APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. Cancer Biol Ther. 2004 Oct; 3(10):960-4. PMID: 15326380.
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    182. Boland CR. Clement Richard Boland, Jr., MD: a conversation with the editor. Interview by William Clifford Roberts. Proc (Bayl Univ Med Cent). 2004 Oct; 17(4):444-61. PMID: 16200134.
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    183. Boland CR. Understanding familial colorectal cancer-finding the corner pieces and filling in the center of the puzzle. Gastroenterology. 2004 Jul; 127(1):334-8. PMID: 15236204.
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    184. Boland CR, Barrett KE. Posthumous presentation of the Julius M. Friedenwald medal to Jon I. Isenberg, M.D. Gastroenterology. 2004 Jun; 126(7):1884-9. PMID: 15188183.
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    185. Goel A, Arnold CN, Niedzwiecki D, Carethers JM, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res. 2004 May 01; 64(9):3014-21. PMID: 15126336.
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    186. Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Rüschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R, Hamilton SR, Hiatt RA, Jass J, Lindblom A, Lynch HT, Peltomaki P, Ramsey SD, Rodriguez-Bigas MA, Vasen HF, Hawk ET, Barrett JC, Freedman AN, Srivastava S. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 2004 Feb 18; 96(4):261-8. PMID: 14970275.
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    187. Carethers JM, Smith EJ, Behling CA, Nguyen L, Tajima A, Doctolero RT, Cabrera BL, Goel A, Arnold CA, Miyai K, Boland CR. Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology. 2004 Feb; 126(2):394-401. PMID: 14762775.
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    188. Arnold CN, Goel A, Compton C, Marcus V, Niedzwiecki D, Dowell JM, Wasserman L, Inoue T, Mayer RJ, Bertagnolli MM, Boland CR. Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer. Cancer Biol Ther. 2004 Jan; 3(1):73-8. PMID: 14726676.
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    189. Krishnan K, Aoki T, Ruffin MT, Normolle DP, Boland CR, Brenner DE. Effects of low dose aspirin (81 mg) on proliferating cell nuclear antigen and Amaranthus caudatus labeling in normal-risk and high-risk human subjects for colorectal cancer. Cancer Detect Prev. 2004; 28(2):107-13. PMID: 15068834.
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    190. Boland CR, Goel A. The silence of the genes: matching mismatch repair defects with tumors. Cancer. 2003 Nov 15; 98(10):2091-4. PMID: 14601077.
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    191. Ricciardiello L, Baglioni M, Giovannini C, Pariali M, Cenacchi G, Ripalti A, Landini MP, Sawa H, Nagashima K, Frisque RJ, Goel A, Boland CR, Tognon M, Roda E, Bazzoli F. Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Cancer Res. 2003 Nov 01; 63(21):7256-62. PMID: 14612521.
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    192. Arnold CN, Goel A, Boland CR. Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines. Int J Cancer. 2003 Aug 10; 106(1):66-73. PMID: 12794758.
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    193. Boland CR, Demarco DC. Invited commentary: Preventing colon cancer: looking over the horizon. Proc (Bayl Univ Med Cent). 2003 Jul; 16(3):344-5. PMID: 16278707.
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    194. Tassone P, Tagliaferri P, Viscomi C, Palmieri C, Caraglia M, D'Alessandro A, Galea E, Goel A, Abbruzzese A, Boland CR, Venuta S. Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br J Cancer. 2003 Jun 16; 88(12):1971-8. PMID: 12799645.
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    195. Chang DK, Goel A, Ricciardiello L, Lee DH, Chang CL, Carethers JM, Boland CR. Effect of H(2)O(2) on cell cycle and survival in DNA mismatch repair-deficient and -proficient cell lines. Cancer Lett. 2003 Jun 10; 195(2):243-51. PMID: 12767533.
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    196. Tassone P, Tagliaferri P, Perricelli A, Blotta S, Quaresima B, Martelli ML, Goel A, Barbieri V, Costanzo F, Boland CR, Venuta S. BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. Br J Cancer. 2003 Apr 22; 88(8):1285-91. PMID: 12698198.
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    197. Goel A, Arnold CN, Niedzwiecki D, Chang DK, Ricciardiello L, Carethers JM, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR. Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res. 2003 Apr 01; 63(7):1608-14. PMID: 12670912.
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    198. Lee SH, Chang DK, Goel A, Boland CR, Bugbee W, Boyle DL, Firestein GS. Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis. J Immunol. 2003 Feb 15; 170(4):2214-20. PMID: 12574395.
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    199. Ricciardiello L, Goel A, Mantovani V, Fiorini T, Fossi S, Chang DK, Lunedei V, Pozzato P, Zagari RM, De Luca L, Fuccio L, Martinelli GN, Roda E, Boland CR, Bazzoli F. Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer. Cancer Res. 2003 Feb 15; 63(4):787-92. PMID: 12591727.
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    200. Gasche C, Chang CL, Natarajan L, Goel A, Rhees J, Young DJ, Arnold CN, Boland CR. Identification of frame-shift intermediate mutant cells. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1914-9. PMID: 12578960.
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    201. Boland CR, Goel A. A rat virus visits the clinic: translating basic discoveries into clinical medicine in the 21st century. Gut. 2003 Jan; 52(1):8-9. PMID: 12477748.
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    202. Goel A, Chang DK, Ricciardiello L, Gasche C, Boland CR. A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells. Clin Cancer Res. 2003 Jan; 9(1):383-90. PMID: 12538492.
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    203. Shadan FF, Cunningham C, Boland CR. JC virus: a biomarker for colorectal cancer? Med Hypotheses. 2002 Dec; 59(6):667-9. PMID: 12445507.
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    204. Magrini R, Bhonde MR, Hanski ML, Notter M, Scherübl H, Boland CR, Zeitz M, Hanski C. Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status. Int J Cancer. 2002 Sep 01; 101(1):23-31. PMID: 12209584.
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    205. Chang CL, Marra G, Chauhan DP, Ha HT, Chang DK, Ricciardiello L, Randolph A, Carethers JM, Boland CR. Oxidative stress inactivates the human DNA mismatch repair system. Am J Physiol Cell Physiol. 2002 Jul; 283(1):C148-54. PMID: 12055083.
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    206. Laghi L, Orbetegli O, Bianchi P, Zerbi A, Di Carlo V, Boland CR, Malesci A. Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers. Oncogene. 2002 Jun 20; 21(27):4301-6. PMID: 12082617.
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    207. Boland CR. Molecular basis for stool-based DNA tests for colorectal cancer: a primer for clinicians. Rev Gastroenterol Disord. 2002; 2 Suppl 1:S12-9. PMID: 12439394.
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    208. Goel A, Arnold CN, Boland CR. Multistep progression of colorectal cancer in the setting of microsatellite instability: new details and novel insights. Gastroenterology. 2001 Dec; 121(6):1497-502. PMID: 11729129.
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    209. Goel A, Boland CR, Chauhan DP. Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett. 2001 Oct 30; 172(2):111-8. PMID: 11566484.
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    210. Gasche C, Chang CL, Rhees J, Goel A, Boland CR. Oxidative stress increases frameshift mutations in human colorectal cancer cells. Cancer Res. 2001 Oct 15; 61(20):7444-8. PMID: 11606378.
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    211. Chang DK, Metzgar D, Wills C, Boland CR. Microsatellites in the eukaryotic DNA mismatch repair genes as modulators of evolutionary mutation rate. Genome Res. 2001 Jul; 11(7):1145-6. PMID: 11435395.
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    212. Boland CR, Yamada T. American Gastroenterological Association. Our new president--Jon I. Isenberg, M.D. Gastroenterology. 2001 May; 120(6):1518-21. PMID: 11313322.
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    213. Huang SC, Lavine JE, Boland PS, Newbury RO, Kolodner R, Pham TT, Arnold CN, Boland CR, Carethers JM. Germline characterization of early-aged onset of hereditary non-polyposis colorectal cancer. J Pediatr. 2001 May; 138(5):629-35. PMID: 11343035.
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    214. Krishnan K, Ruffin MT, Normolle D, Shureiqi I, Burney K, Bailey J, Peters-Golden M, Rock CL, Boland CR, Brenner DE. Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2001 May; 10(5):447-53. PMID: 11352853.
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    215. Boland CR, Savides TJ. The changing scope of colorectal cancer. Gut. 2001 Apr; 48(4):449-50. PMID: 11288733.
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    216. Yashiro M, Carethers JM, Laghi L, Saito K, Slezak P, Jaramillo E, Rubio C, Koizumi K, Hirakawa K, Boland CR. Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res. 2001 Mar 15; 61(6):2676-83. PMID: 11289147.
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    217. Ricciardiello L, Chang DK, Laghi L, Goel A, Chang CL, Boland CR. Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissues. J Virol. 2001 Feb; 75(4):1996-2001. PMID: 11160700.
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    218. Müller W, Burgart LJ, Krause-Paulus R, Thibodeau SN, Almeida M, Edmonston TB, Boland CR, Sutter C, Jass JR, Lindblom A, Lubinski J, MacDermot K, Sanders DS, Morreau H, Müller A, Oliani C, Orntoft T, Ponz De Leon M, Rosty C, Rodriguez-Bigas M, Rüschoff J, Ruszkiewicz A, Sabourin J, Salovaara R, Möslein G. The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC)--results of an international collaborative study. Fam Cancer. 2001; 1(2):87-92. PMID: 14574003.
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    219. Ricciardiello L, Laghi L, Ramamirtham P, Chang CL, Chang DK, Randolph AE, Boland CR. JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract. Gastroenterology. 2000 Nov; 119(5):1228-35. PMID: 11054380.
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    220. Chauhan DP, Yang Q, Carethers JM, Marra G, Chang CL, Chamberlain SM, Boland CR. Antisense inhibition of hMLH1 is not sufficient for loss of DNA mismatch repair function in the HCT116+chromosome 3 cell line. Clin Cancer Res. 2000 Oct; 6(10):3827-31. PMID: 11051225.
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    221. Chang DK, Ricciardiello L, Goel A, Chang CL, Boland CR. Steady-state regulation of the human DNA mismatch repair system. J Biol Chem. 2000 Jun 16; 275(24):18424-31. PMID: 10747992.
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    222. Boland CR. Molecular genetics of hereditary nonpolyposis colorectal cancer. Ann N Y Acad Sci. 2000 Jun; 910:50-9; discussion 59-61. PMID: 10911905.
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    223. Yan H, Papadopoulos N, Marra G, Perrera C, Jiricny J, Boland CR, Lynch HT, Chadwick RB, de la Chapelle A, Berg K, Eshleman JR, Yuan W, Markowitz S, Laken SJ, Lengauer C, Kinzler KW, Vogelstein B. Conversion of diploidy to haploidy. Nature. 2000 Feb 17; 403(6771):723-4. PMID: 10693791.
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    224. Boland CR, Sinicrope FA, Brenner DE, Carethers JM. Colorectal cancer prevention and treatment. Gastroenterology. 2000 Feb; 118(2 Suppl 1):S115-28. PMID: 10868902.
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    225. Boland CR, Ricciardiello L. How many mutations does it take to make a tumor? Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14675-7. PMID: 10611270.
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    226. Carethers JM, Chauhan DP, Fink D, Nebel S, Bresalier RS, Howell SB, Boland CR. Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology. 1999 Jul; 117(1):123-31. PMID: 10381918.
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    227. Laghi L, Randolph AE, Chauhan DP, Marra G, Major EO, Neel JV, Boland CR. JC virus DNA is present in the mucosa of the human colon and in colorectal cancers. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7484-9. PMID: 10377441.
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    228. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN, Srivastava S. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998 Nov 15; 58(22):5248-57. PMID: 9823339.
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    229. Foss FM, Raubitscheck A, Mulshine JL, Fleisher TA, Reynolds JC, Paik CH, Neumann RD, Boland C, Perentesis P, Brown MR, Frincke JM, Lollo CP, Larson SM, Carrasquillo JA. Phase I study of the pharmacokinetics of a radioimmunoconjugate, 90Y-T101, in patients with CD5-expressing leukemia and lymphoma. Clin Cancer Res. 1998 Nov; 4(11):2691-700. PMID: 9829731.
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    230. Macdonald GA, Greenson JK, Saito K, Cherian SP, Appelman HD, Boland CR. Microsatellite instability and loss of heterozygosity at DNA mismatch repair gene loci occurs during hepatic carcinogenesis. Hepatology. 1998 Jul; 28(1):90-7. PMID: 9657101.
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    231. Carethers JM, Furnari FB, Zigman AF, Lavine JE, Jones MC, Graham GE, Teebi AS, Huang HJ, Ha HT, Chauhan DP, Chang CL, Cavenee WK, Boland CR. Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome. Cancer Res. 1998 Jul 01; 58(13):2724-6. PMID: 9661881.
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    232. Carethers JM, Hawn MT, Greenson JK, Hitchcock CL, Boland CR. Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. Gastroenterology. 1998 Jun; 114(6):1188-95. PMID: 9609755.
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    233. Davis TW, Wilson-Van Patten C, Meyers M, Kunugi KA, Cuthill S, Reznikoff C, Garces C, Boland CR, Kinsella TJ, Fishel R, Boothman DA. Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. Cancer Res. 1998 Feb 15; 58(4):767-78. PMID: 9485033.
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    234. Boland CR, Sato J, Saito K, Carethers JM, Marra G, Laghi L, Chauhan DP. Genetic instability and chromosomal aberrations in colorectal cancer: a review of the current models. Cancer Detect Prev. 1998; 22(5):377-82. PMID: 9727618.
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    235. Rodriguez-Bigas MA, Boland CR, Hamilton SR, Henson DE, Jass JR, Khan PM, Lynch H, Perucho M, Smyrk T, Sobin L, Srivastava S. A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst. 1997 Dec 03; 89(23):1758-62. PMID: 9392616.
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    236. Boland CR. Genetic pathways to colorectal cancer. Hosp Pract (1995). 1997 Nov 15; 32(11):79-84, 87-96. PMID: 9385315.
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    237. Zigman AF, Lavine JE, Jones MC, Boland CR, Carethers JM. Localization of the Bannayan-Riley-Ruvalcaba syndrome gene to chromosome 10q23. Gastroenterology. 1997 Nov; 113(5):1433-7. PMID: 9352843.
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    238. Umar A, Koi M, Risinger JI, Glaab WE, Tindall KR, Kolodner RD, Boland CR, Barrett JC, Kunkel TA. Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res. 1997 Sep 15; 57(18):3949-55. PMID: 9307278.
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    239. Ruffin MT, Krishnan K, Rock CL, Normolle D, Vaerten MA, Peters-Golden M, Crowell J, Kelloff G, Boland CR, Brenner DE. Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose. J Natl Cancer Inst. 1997 Aug 06; 89(15):1152-60. PMID: 9262254.
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    240. Binnie CG, Kam-Morgan LN, Cayouette MC, Marra G, Boland CR, Luce M. Rapid identification of RT-PCR clones containing translation-terminating mutations. Mutat Res. 1997 Jan 15; 388(1):21-6. PMID: 9025788.
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    241. Marra G, Boland CR. DNA repair and colorectal cancer. Gastroenterol Clin North Am. 1996 Dec; 25(4):755-72. PMID: 8960891.
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    242. Marra G, Chang CL, Laghi LA, Chauhan DP, Young D, Boland CR. Expression of human MutS homolog 2 (hMSH2) protein in resting and proliferating cells. Oncogene. 1996 Nov 21; 13(10):2189-96. PMID: 8950986.
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    243. Lee PJ, Washer LL, Law DJ, Boland CR, Horon IL, Feinberg AP. Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10366-70. PMID: 8816806.
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    244. Boland CR. Setting microsatellites free. Nat Med. 1996 Sep; 2(9):972-4. PMID: 8782450.
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    245. Aebi S, Kurdi-Haidar B, Gordon R, Cenni B, Zheng H, Fink D, Christen RD, Boland CR, Koi M, Fishel R, Howell SB. Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res. 1996 Jul 01; 56(13):3087-90. PMID: 8674066.
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    246. Carethers JM, Hawn MT, Chauhan DP, Luce MC, Marra G, Koi M, Boland CR. Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine. J Clin Invest. 1996 Jul 01; 98(1):199-206. PMID: 8690794.
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    247. LaRusso NF, Phillips SF, Bloomer JR, Boland CR, Chang EB, DiMagno EP, Giannella RA, Gores GJ, Malagelada JR, Miller LJ, Rakela J, Szurszewski JH, Binder HJ, Clain JE, LaMont JT, Link AM. Passing the torch: a look back at our editorship. Gastroenterology. 1996 May; 110(5):1336-8. PMID: 8613036.
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    248. Romano M, Lesch CA, Meise KS, Veljaca M, Sanchez B, Kraus ER, Boland CR, Guglietta A, Coffey RJ. Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats. Gastroenterology. 1996 May; 110(5):1448-55. PMID: 8613050.
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    249. Mellon I, Rajpal DK, Koi M, Boland CR, Champe GN. Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science. 1996 Apr 26; 272(5261):557-60. PMID: 8614807.
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    250. Brentnall TA, Crispin DA, Bronner MP, Cherian SP, Hueffed M, Rabinovitch PS, Rubin CE, Haggitt RC, Boland CR. Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res. 1996 Mar 15; 56(6):1237-40. PMID: 8640805.
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    251. Boland CR. Roles of the DNA mismatch repair genes in colorectal tumorigenesis. Int J Cancer. 1996 Feb 20; 69(1):47-9. PMID: 8600059.
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    252. Yoshimura K, Delbarre SG, Kraus E, Boland CR. The effects of omeprazole and famotidine on mucin and PGE2 release in the rat stomach. Aliment Pharmacol Ther. 1996 Feb; 10(1):111-7. PMID: 8871451.
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    253. Boland CR, Sato J, Appelman HD, Bresalier RS, Feinberg AP. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat Med. 1995 Sep; 1(9):902-9. PMID: 7585215.
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    254. Hawn MT, Umar A, Carethers JM, Marra G, Kunkel TA, Boland CR, Koi M. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res. 1995 Sep 01; 55(17):3721-5. PMID: 7641183.
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    255. Marra G, Boland CR. Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J Natl Cancer Inst. 1995 Aug 02; 87(15):1114-25. PMID: 7674315.
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    256. Koi M, Umar A, Chauhan DP, Cherian SP, Carethers JM, Kunkel TA, Boland CR. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 1994 Aug 15; 54(16):4308-12. PMID: 8044777.
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    257. Chen YF, Boland CR, Kraus ER, Goldstein IJ. The lectin Griffonia simplicifolia I-A4 (GS I-A4) specifically recognizes terminal alpha-linked N-acetylgalactosaminyl groups and is cytotoxic to the human colon cancer cell lines LS174t and SW1116. Int J Cancer. 1994 May 15; 57(4):561-7. PMID: 7514154.
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    258. Niv Y, Boland CR, Kim YS. Increased tumorigenicity after differentiation of colon cancer cell line: absence of association with mucin synthesis. Gastroenterology. 1994 Feb; 106(2):389-98. PMID: 8299906.
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    259. Boland CR. The biology of colorectal cancer. Implications for pretreatment and follow-up management. Cancer. 1993 Jun 15; 71(12 Suppl):4180-6. PMID: 8508377.
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    260. Lynch HT, Smyrk TC, Watson P, Lanspa SJ, Lynch JF, Lynch PM, Cavalieri RJ, Boland CR. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology. 1993 May; 104(5):1535-49. PMID: 8482467.
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    261. Romano M, Polk WH, Awad JA, Arteaga CL, Nanney LB, Wargovich MJ, Kraus ER, Boland CR, Coffey RJ. Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo. J Clin Invest. 1992 Dec; 90(6):2409-21. PMID: 1281834.
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    262. Scheiman JM, Kraus ER, Yoshimura K, Boland CR. Effect of sucralfate on components of mucosal barrier produced by cultured canine epithelial cells in vitro. Dig Dis Sci. 1992 Dec; 37(12):1853-9. PMID: 1473434.
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    263. Scheiman JM, Kraus ER, Boland CR. Regulation of canine gastric mucin synthesis and phospholipid secretion by acid secretagogues. Gastroenterology. 1992 Dec; 103(6):1842-50. PMID: 1333428.
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    264. Boland CR, Kolars JC. Fiber and colon cancer: the weight of the evidence. Gastroenterology. 1992 Dec; 103(6):1964-7. PMID: 1333430.
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    265. Feinberg AP, Johnson LA, Law DJ, Kuehn SE, Steenman M, Williams BR, Thomas G, Boland CR, Rainier S, Koi M. Multiple tumor suppressor genes in multistep carcinogenesis. Tohoku J Exp Med. 1992 Oct; 168(2):149-52. PMID: 1339099.
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    266. Lynch HT, Watson P, Smyrk TC, Lanspa SJ, Boman BM, Boland CR, Lynch JF, Cavalieri RJ, Leppert M, White R. Colon cancer genetics. Cancer. 1992 Sep 01; 70(5 Suppl):1300-12. PMID: 1511377.
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    267. Yoshimura K, Kraus ER, Shimakura S, Scheiman JM, Boland CR. Role of prostaglandin E2 in cholinergic-mediated glycoprotein synthesis in canine antrum. Dig Dis Sci. 1992 Jul; 37(7):1045-50. PMID: 1618052.
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    268. Shimakura S, Boland CR. Eicosanoid production by the human gastric cancer cell line AGS and its relation to cell growth. Cancer Res. 1992 Apr 01; 52(7):1744-9. PMID: 1551103.
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    269. Scheiman JM, Kraus ER, Bonnville LA, Weinhold PA, Boland CR. Synthesis and prostaglandin E2-induced secretion of surfactant phospholipid by isolated gastric mucous cells. Gastroenterology. 1991 May; 100(5 Pt 1):1232-40. PMID: 1707384.
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    270. Boland CR, Chen YF, Rinderle SJ, Resau JH, Luk GD, Lynch HT, Goldstein IJ. Use of the lectin from Amaranthus caudatus as a histochemical probe of proliferating colonic epithelial cells. Cancer Res. 1991 Jan 15; 51(2):657-65. PMID: 1985783.
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    271. Sams JS, Lynch HT, Burt RW, Lanspa SJ, Boland CR. Abnormalities of lectin histochemistry in familial polyposis coli and hereditary nonpolyposis colorectal cancer. Cancer. 1990 Aug 01; 66(3):502-8. PMID: 2194645.
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    272. Boland CR, Deshmukh GD. The carbohydrate composition of mucin in colonic cancer. Gastroenterology. 1990 May; 98(5 Pt 1):1170-7. PMID: 2323510.
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    273. Boland CR, Roberts JA. Quantitation of lectin binding sites in human colon mucins by use of peanut and wheat germ agglutinins. J Histochem Cytochem. 1988 Oct; 36(10):1305-7. PMID: 3138307.
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    274. Boland CR, Bresalier RS, Roberts JA. Assay of lectin binding sites in colon cancer-associated mucins: comparison of fluorescence microscopy with a quantitative chromatographic technique. J Histochem Cytochem. 1988 Oct; 36(10):1329-34. PMID: 3138308.
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    275. Shimamoto C, Weinstein WM, Boland CR. Glycoconjugate expression in normal, metaplastic, and neoplastic human upper gastrointestinal mucosa. J Clin Invest. 1987 Dec; 80(6):1670-8. PMID: 3680520.
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    276. Boland CR, Kim YS. Transitional mucosa of the colon and tumor growth factors. Med Hypotheses. 1987 Mar; 22(3):237-43. PMID: 3473277.
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    277. Boland CR, Clapp NK. Glycoconjugates in the colons of New World monkeys with spontaneous colitis. Association between inflammation and neoplasia. Gastroenterology. 1987 Mar; 92(3):625-34. PMID: 3102306.
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    278. Yuan M, Itzkowitz SH, Boland CR, Kim YD, Tomita JT, Palekar A, Bennington JL, Trump BF, Kim YS. Comparison of T-antigen expression in normal, premalignant, and malignant human colonic tissue using lectin and antibody immunohistochemistry. Cancer Res. 1986 Sep; 46(9):4841-7. PMID: 3731131.
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    279. Boland CR. Mucin glycoproteins in chronic ulcerative colitis. Peanut lectin binding in human and nonhuman primate colons. Dig Dis Sci. 1985 Dec; 30(12 Suppl):147S-153S. PMID: 3933933.
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    280. Bresalier RS, Boland CR, Kim YS. Regional differences in normal and cancer-associated glycoconjugates of the human colon. J Natl Cancer Inst. 1985 Aug; 75(2):249-60. PMID: 3927049.
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    281. Boland CR, Ahnen DJ. Binding of lectins to goblet cell mucin in malignant and premalignant colonic epithelium in the CF-1 mouse. Gastroenterology. 1985 Jul; 89(1):127-37. PMID: 3891494.
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    282. Boland CR, Lance P, Levin B, Riddell RH, Kim YS. Abnormal goblet cell glycoconjugates in rectal biopsies associated with an increased risk of neoplasia in patients with ulcerative colitis: early results of a prospective study. Gut. 1984 Dec; 25(12):1364-71. PMID: 6510769.
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    283. Bresalier RS, Boland CR, Kim YS. Characteristics of colorectal carcinoma cells with high metastatic potential. Gastroenterology. 1984 Jul; 87(1):115-22. PMID: 6724253.
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    284. Boland CR, Montgomery CK, Kim YS. A cancer-associated mucin alteration in benign colonic polyps. Gastroenterology. 1982 Apr; 82(4):664-72. PMID: 6800870.
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