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    Koichi Masuda

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentOrthopedic Surgery
    Address9500 Gilman Drive #0863
    CA La Jolla 92093
    Phone858-246-0426
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Bioinspired Synthetic Grafts for Bone Regeneration
      NIH/NIAMS R01AR063184Aug 1, 2013 - May 31, 2018
      Role: Principal Investigator
      Program Project grant
      NIH P01AR048152Sep 30, 2001 - Aug 31, 2012
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Akeda K, Ohishi K, Masuda K, Bae WC, Takegami N, Yamada J, Nakamura T, Sakakibara T, Kasai Y, Sudo A. Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial. Asian Spine J. 2017 Jun; 11(3):380-389. PMID: 28670405.
        View in: PubMed
      2. Takegami N, Akeda K, Yamada J, Sano T, Murata K, Huang J, Masuda K, Sudo A. RANK/RANKL/OPG system in the intervertebral disc. Arthritis Res Ther. 2017 Jun 02; 19(1):121. PMID: 28576140.
        View in: PubMed
      3. Alvarez-Garcia O, Matsuzaki T, Olmer M, Masuda K, Lotz MK. Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. J Orthop Res. 2017 Apr 21. PMID: 28430387.
        View in: PubMed
      4. Fukui D, Kawakami M, Cheng K, Murata K, Yamada K, Sato R, Yoshida M, Yamada H, Inoue N, Masuda K. Three-dimensional micro-computed tomography analysis for spinal instability after lumbar facetectomy in the rat. Eur Spine J. 2017 Aug; 26(8):2014-2020. PMID: 28012080.
        View in: PubMed
      5. Hwang D, Kim S, Abeydeera NA, Statum S, Masuda K, Chung CB, Siriwanarangsun P, Bae WC. Quantitative magnetic resonance imaging of the lumbar intervertebral discs. Quant Imaging Med Surg. 2016 Dec; 6(6):744-755. PMID: 28090450.
        View in: PubMed
      6. Caffrey JP, Cory E, Wong VW, Masuda K, Chen AC, Hunt JP, Ganey TM, Sah RL. Ex vivo loading of trussed implants for spine fusion induces heterogeneous strains consistent with homeostatic bone mechanobiology. J Biomech. 2016 Dec 08; 49(16):4090-4097. PMID: 27836500.
        View in: PubMed
      7. Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz MK, Sakai D, Masuda K, Ozaki T, Asahara H. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun. 2016 Aug 16; 7:12503. PMID: 27527664; PMCID: PMC4990710.
      8. Nakai T, Sakai D, Nakamura Y, Nukaga T, Grad S, Li Z, Alini M, Chan D, Masuda K, Ando K, Mochida J, Watanabe M. CD146 defines commitment of cultured annulus fibrosus cells to express a contractile phenotype. J Orthop Res. 2016 Aug; 34(8):1361-72. PMID: 27273299.
        View in: PubMed
      9. Watson D, Reuther MS, Wong VW, Sah RL, Masuda K, Briggs KK. Effect of hyaluronidase on tissue-engineered human septal cartilage. Laryngoscope. 2016 Sep; 126(9):1984-9. PMID: 27297023; PMCID: PMC4996773 [Available on 09/01/17].
      10. Chen KC, Tran B, Biswas R, Statum S, Masuda K, Chung CB, Bae WC. Evaluation of the disco-vertebral junction using ultrashort time-to-echo magnetic resonance imaging: inter-reader agreement and association with vertebral endplate lesions. Skeletal Radiol. 2016 Sep; 45(9):1249-56. PMID: 27241121; PMCID: PMC4947562 [Available on 09/01/17].
      11. Temple-Wong MM, Ren S, Quach P, Hansen BC, Chen AC, Hasegawa A, D'Lima DD, Koziol J, Masuda K, Lotz MK, Sah RL. Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. Arthritis Res Ther. 2016 Jan 21; 18:18. PMID: 26792492; PMCID: PMC4721052.
      12. Shih YR, Phadke A, Yamaguchi T, Kang H, Inoue N, Masuda K, Varghese S. Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. Acta Biomater. 2015 Jun; 19:1-9. PMID: 25805106.
        View in: PubMed
      13. Nemoto H, Watson D, Masuda K. Transplantation of Tissue-Engineered Cartilage in an Animal Model (Xenograft and Autograft): Construct Validation. Methods Mol Biol. 2015; 1340:247-59. PMID: 26445844.
        View in: PubMed
      14. Kurakawa T, Kakutani K, Morita Y, Kato Y, Yurube T, Hirata H, Miyazaki S, Terashima Y, Maeno K, Takada T, Doita M, Kurosaka M, Inoue N, Masuda K, Nishida K. Functional impact of integrin a5ß1 on the homeostasis of intervertebral discs: a study of mechanotransduction pathways using a novel dynamic loading organ culture system. Spine J. 2015 Mar 01; 15(3):417-26. PMID: 25546513.
        View in: PubMed
      15. Zhang B, Roh YS, Liang S, Liu C, Naiki M, Masuda K, Seki E. Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-?B and JNK in hepatocytes. PLoS One. 2014; 9(12):e114071. PMID: 25470242; PMCID: PMC4254918.
      16. Yamaguchi T, Goto S, Nishigaki Y, Espinoza Orías AA, Bae WC, Masuda K, Inoue N. Microstructural analysis of three-dimensional canal network in the rabbit lumbar vertebral endplate. J Orthop Res. 2015 Feb; 33(2):270-6. PMID: 25367593.
        View in: PubMed
      17. Leung VY, Aladin DM, Lv F, Tam V, Sun Y, Lau RY, Hung SC, Ngan AH, Tang B, Lim CT, Wu EX, Luk KD, Lu WW, Masuda K, Chan D, Cheung KM. Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair. Stem Cells. 2014 Aug; 32(8):2164-77. PMID: 24737495.
        View in: PubMed
      18. Kushnaryov A, Yamaguchi T, Briggs KK, Wong VW, Reuther M, Neuman M, Lin V, Sah RL, Masuda K, Watson D. Evaluation of Autogenous Engineered Septal Cartilage Grafts in Rabbits- A Minimally Invasive Preclinical Model. Adv Otolaryngol. 2014 Jul 23; 2014:415821. PMID: 25221786.
        View in: PubMed
      19. MacEwan IJ, Glembotski NE, D'Lima D, Bae W, Masuda K, Rashidi HH, Mell LK, Bydder M. Proton density water fraction as a biomarker of bone marrow cellularity: validation in ex vivo spine specimens. Magn Reson Imaging. 2014 Nov; 32(9):1097-101. PMID: 25240720.
        View in: PubMed
      20. Gregory DE, Bae WC, Sah RL, Masuda K. Disc degeneration reduces the delamination strength of the annulus fibrosus in the rabbit annular disc puncture model. Spine J. 2014 Jul 01; 14(7):1265-71. PMID: 24594442; PMCID: PMC4063999.
      21. Yamaguchi T, Inoue N, Sah RL, Lee YP, Taborek AP, Williams GM, Moseley TA, Bae WC, Masuda K. Micro-computed tomography-based three-dimensional kinematic analysis during lateral bending for spinal fusion assessment in a rat posterolateral lumbar fusion model. Tissue Eng Part C Methods. 2014 Jul; 20(7):578-87. PMID: 24199634; PMCID: PMC4074752.
      22. Twu CW, Reuther MS, Briggs KK, Sah RL, Masuda K, Watson D. Effect of oxygen tension on tissue-engineered human nasal septal chondrocytes. Allergy Rhinol (Providence). 2014 Jan; 5(3):125-31. PMID: 25565047; PMCID: PMC4275457.
      23. Reuther MS, Briggs KK, Neuman MK, Masuda K, Sah RL, Watson D. Volume Expansion of Tissue Engineered Human Nasal Septal Cartilage. J Otol Rhinol. 2014; 3(4). PMID: 25554747.
        View in: PubMed
      24. Neuman MK, Briggs KK, Masuda K, Sah RL, Watson D. A compositional analysis of cadaveric human nasal septal cartilage. Laryngoscope. 2013 Sep; 123(9):2120-4. PMID: 23821477; PMCID: PMC3775909.
      25. Reuther MS, Briggs KK, Neuman MK, Masuda K, Sah RL, Watson D. Shape fidelity of native and engineered human nasal septal cartilage. Otolaryngol Head Neck Surg. 2013 May; 148(5):753-7. PMID: 23426709; PMCID: PMC4061292.
      26. Caffrey JP, Kushnaryov AM, Reuther MS, Wong VW, Briggs KK, Masuda K, Sah RL, Watson D. Flexural properties of native and tissue-engineered human septal cartilage. Otolaryngol Head Neck Surg. 2013 Apr; 148(4):576-81. PMID: 23322630; PMCID: PMC4038656.
      27. McCarty WJ, Cheng JC, Hansen BC, Yamaguchi T, Firestein GS, Masuda K, Sah RL. The biophysical mechanisms of altered hyaluronan concentration in synovial fluid after anterior cruciate ligament transection. Arthritis Rheum. 2012 Dec; 64(12):3993-4003. PMID: 22933328; PMCID: PMC3510334.
      28. Bae WC, Statum S, Zhang Z, Yamaguchi T, Wolfson T, Gamst AC, Du J, Bydder GM, Masuda K, Chung CB. Morphology of the cartilaginous endplates in human intervertebral disks with ultrashort echo time MR imaging. Radiology. 2013 Feb; 266(2):564-74. PMID: 23192776; PMCID: PMC3558871.
      29. Obata S, Akeda K, Imanishi T, Masuda K, Bae W, Morimoto R, Asanuma Y, Kasai Y, Uchida A, Sudo A. Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study. Arthritis Res Ther. 2012 Nov 05; 14(6):R241. PMID: 23127251; PMCID: PMC3674597.
      30. Lotz JC, Haughton V, Boden SD, An HS, Kang JD, Masuda K, Freemont A, Berven S, Sengupta DK, Tanenbaum L, Maurer P, Ranganathan A, Alavi A, Marinelli NL. New treatments and imaging strategies in degenerative disease of the intervertebral disks. Radiology. 2012 Jul; 264(1):6-19. PMID: 22723559.
        View in: PubMed
      31. Reuther MS, Briggs KK, Schumacher BL, Masuda K, Sah RL, Watson D. In vivo oxygen tension in human septal cartilage increases with age. Laryngoscope. 2012 Nov; 122(11):2407-10. PMID: 22740061; PMCID: PMC4037531.
      32. Pallante AL, Chen AC, Ball ST, Amiel D, Masuda K, Sah RL, Bugbee WD. The in vivo performance of osteochondral allografts in the goat is diminished with extended storage and decreased cartilage cellularity. Am J Sports Med. 2012 Aug; 40(8):1814-23. PMID: 22707746; PMCID: PMC4041579.
      33. Reuther MS, Wong VW, Briggs KK, Chang AA, Nguyen QT, Schumacher BL, Masuda K, Sah RL, Watson D. Culture of human septal chondrocytes in a rotary bioreactor. Otolaryngol Head Neck Surg. 2012 Oct; 147(4):661-7. PMID: 22597575; PMCID: PMC4082692.
      34. Gregory DE, Bae WC, Sah RL, Masuda K. Anular delamination strength of human lumbar intervertebral disc. Eur Spine J. 2012 Sep; 21(9):1716-23. PMID: 22547212; PMCID: PMC3459123.
      35. Bae WC, Chen PC, Chung CB, Masuda K, D'Lima D, Du J. Quantitative ultrashort echo time (UTE) MRI of human cortical bone: correlation with porosity and biomechanical properties. J Bone Miner Res. 2012 Apr; 27(4):848-57. PMID: 22190232; PMCID: PMC3463505.
      36. Chan EF, Harjanto R, Asahara H, Inoue N, Masuda K, Bugbee WD, Firestein GS, Hosalkar HS, Lotz MK, Sah RL. Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice. Orthop Clin North Am. 2012 Apr; 43(2):173-85, v. PMID: 22480467; PMCID: PMC3321216.
      37. Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S, Grad S, Alini M, Risbud MV, Chan D, Cheah KS, Yamamura K, Masuda K, Okano H, Ando K, Mochida J. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun. 2012; 3:1264. PMID: 23232394; PMCID: PMC3535337.
      38. Biswas R, Bae W, Diaz E, Masuda K, Chung CB, Bydder GM, Du J. Ultrashort echo time (UTE) imaging with bi-component analysis: bound and free water evaluation of bovine cortical bone subject to sequential drying. Bone. 2012 Mar; 50(3):749-55. PMID: 22178540; PMCID: PMC3463503.
      39. Raheem O, Kulidjian AA, Wu C, Jeong YB, Yamaguchi T, Smith KM, Goff D, Leu H, Morris SR, Cacalano NA, Masuda K, Jamieson CH, Kane CJ, Jamieson CA. A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions. J Transl Med. 2011 Oct 28; 9:185. PMID: 22035283; PMCID: PMC3269442.
      40. Bae WC, Masuda K. Emerging technologies for molecular therapy for intervertebral disk degeneration. Orthop Clin North Am. 2011 Oct; 42(4):585-601, ix. PMID: 21944594; PMCID: PMC4029337.
      41. Brown SH, Gregory DE, Carr JA, Ward SR, Masuda K, Lieber RL. ISSLS prize winner: Adaptations to the multifidus muscle in response to experimentally induced intervertebral disc degeneration. Spine (Phila Pa 1976). 2011 Oct 01; 36(21):1728-36. PMID: 21301396.
        View in: PubMed
      42. McCarty WJ, Masuda K, Sah RL. Fluid movement and joint capsule strains due to flexion in rabbit knees. J Biomech. 2011 Nov 10; 44(16):2761-7. PMID: 21945567; PMCID: PMC3241937.
      43. Hui AY, McCarty WJ, Masuda K, Firestein GS, Sah RL. A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb; 4(1):15-37. PMID: 21826801; PMCID: PMC3593048.
      44. Upasani VV, Farnsworth CL, Chambers RC, Bastrom TP, Williams GM, Sah RL, Masuda K, Newton PO. Intervertebral disc health preservation after six months of spinal growth modulation. J Bone Joint Surg Am. 2011 Aug 03; 93(15):1408-16. PMID: 21915546; PMCID: PMC3143582.
      45. Siemionow K, An H, Masuda K, Andersson G, Cs-Szabo G. The effects of age, sex, ethnicity, and spinal level on the rate of intervertebral disc degeneration: a review of 1712 intervertebral discs. Spine (Phila Pa 1976). 2011 Aug 01; 36(17):1333-9. PMID: 21217432; PMCID: PMC3117081.
      46. Mwale F, Masuda K, Pichika R, Epure LM, Yoshikawa T, Hemmad A, Roughley PJ, Antoniou J. The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration. Arthritis Res Ther. 2011 Jul 25; 13(4):R120. PMID: 21787415; PMCID: PMC3239358.
      47. An HS, Masuda K, Cs-Szabo G, Zhang Y, Chee A, Andersson GB, Im HJ, Thonar EJ, Kwon YM. Biologic repair and regeneration of the intervertebral disk. J Am Acad Orthop Surg. 2011 Jul; 19(7):450-2. PMID: 21724924.
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      48. Li J, Muehleman C, Abe Y, Masuda K. Prevalence of facet joint degeneration in association with intervertebral joint degeneration in a sample of organ donors. J Orthop Res. 2011 Aug; 29(8):1267-74. PMID: 21360583; PMCID: PMC3115475.
      49. McCarty WJ, Luan A, Siddiqui M, Hansen BC, Masuda K, Sah RL. Biomechanical properties of mixtures of blood and synovial fluid. J Orthop Res. 2011 Feb; 29(2):240-6. PMID: 21226237; PMCID: PMC3057681.
      50. Alexander TH, Sage AB, Chen AC, Schumacher BL, Shelton E, Masuda K, Sah RL, Watson D. Insulin-like growth factor-I and growth differentiation factor-5 promote the formation of tissue-engineered human nasal septal cartilage. Tissue Eng Part C Methods. 2010 Oct; 16(5):1213-21. PMID: 20178406; PMCID: PMC2943402.
      51. Muehleman C, Margulis A, Bae WC, Masuda K. Relationship between knee and ankle degeneration in a population of organ donors. BMC Med. 2010 Jul 28; 8:48. PMID: 20667091; PMCID: PMC2925325.
      52. Han EH, Wilensky LM, Schumacher BL, Chen AC, Masuda K, Sah RL. Tissue engineering by molecular disassembly and reassembly: biomimetic retention of mechanically functional aggrecan in hydrogel. Tissue Eng Part C Methods. 2010 Dec; 16(6):1471-9. PMID: 20486781; PMCID: PMC2988632.
      53. Williams GM, Dills KJ, Flores CR, Stender ME, Stewart KM, Nelson LM, Chen AC, Masuda K, Hazelwood SJ, Klisch SM, Sah RL. Differential regulation of immature articular cartilage compressive moduli and Poisson's ratios by in vitro stimulation with IGF-1 and TGF-beta1. J Biomech. 2010 Sep 17; 43(13):2501-7. PMID: 20570267; PMCID: PMC2937078.
      54. Hwang J, Kyubwa EM, Bae WC, Bugbee WD, Masuda K, Sah RL. In Vitro Calcification of Immature Bovine Articular Cartilage: Formation of a Functional Zone of Calcified Cartilage. Cartilage. 2010 Oct 01; 1(4):287-297. PMID: 22745850.
        View in: PubMed
      55. Chawla K, Masuda K, Sah RL. Tracking chondrocytes and assessing their proliferation with carboxyfluorescein diacetate succinimidyl ester: effects on cell functions. Tissue Eng Part C Methods. 2010 Apr; 16(2):301-10. PMID: 19558220; PMCID: PMC2946884.
      56. Masuda K, Lotz JC. New challenges for intervertebral disc treatment using regenerative medicine. Tissue Eng Part B Rev. 2010 Feb; 16(1):147-58. PMID: 19903086; PMCID: PMC2817669.
      57. Seki S, Asanuma-Abe Y, Masuda K, Kawaguchi Y, Asanuma K, Muehleman C, Iwai A, Kimura T. Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model. Arthritis Res Ther. 2009; 11(6):R166. PMID: 19889209; PMCID: PMC3003501.
      58. Akeda K, Nishimura A, Satonaka H, Shintani K, Kusuzaki K, Matsumine A, Kasai Y, Masuda K, Uchida A. Three-dimensional alginate spheroid culture system of murine osteosarcoma. Oncol Rep. 2009 Nov; 22(5):997-1003. PMID: 19787212.
        View in: PubMed
      59. Hsieh-Bonassera ND, Wu I, Lin JK, Schumacher BL, Chen AC, Masuda K, Bugbee WD, Sah RL. Expansion and redifferentiation of chondrocytes from osteoarthritic cartilage: cells for human cartilage tissue engineering. Tissue Eng Part A. 2009 Nov; 15(11):3513-23. PMID: 19456239; PMCID: PMC2792054.
      60. Williams GM, Chan EF, Temple-Wong MM, Bae WC, Masuda K, Bugbee WD, Sah RL. Shape, loading, and motion in the bioengineering design, fabrication, and testing of personalized synovial joints. J Biomech. 2010 Jan 05; 43(1):156-65. PMID: 19815214; PMCID: PMC2813363.
      61. Muehleman C, Li J, Abe Y, Pfister B, Sah RL, Phipps R, Masuda K. Effect of risedronate in a minipig cartilage defect model with allograft. J Orthop Res. 2009 Mar; 27(3):360-5. PMID: 18925648; PMCID: PMC2941977.
      62. Iida R, Akeda K, Kasai Y, Masuda K, Morimoto R, Sakakibara T, Sato M, Uchida A. Expression of proteinase-activated receptor-2 in the intervertebral disc. Spine (Phila Pa 1976). 2009 Mar 01; 34(5):470-8. PMID: 19247167.
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      63. Singh K, Masuda K, Thonar EJ, An HS, Cs-Szabo G. Age-related changes in the extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc. Spine (Phila Pa 1976). 2009 Jan 01; 34(1):10-6. PMID: 19127156; PMCID: PMC2837353.
      64. Masuda K. Biological repair of the degenerated intervertebral disc by the injection of growth factors. Eur Spine J. 2008 Dec; 17 Suppl 4:441-51. PMID: 19005698; PMCID: PMC2587664.
      65. Kitahara S, Nakagawa K, Sah RL, Wada Y, Ogawa T, Moriya H, Masuda K. In vivo maturation of scaffold-free engineered articular cartilage on hydroxyapatite. Tissue Eng Part A. 2008 Nov; 14(11):1905-13. PMID: 18620479.
        View in: PubMed
      66. Klisch SM, Asanbaeva A, Oungoulian SR, Masuda K, Thonar EJ, Davol A, Sah RL. A cartilage growth mixture model with collagen remodeling: validation protocols. J Biomech Eng. 2008 Jun; 130(3):031006. PMID: 18532855; PMCID: PMC2692927.
      67. Han EH, Bae WC, Hsieh-Bonassera ND, Wong VW, Schumacher BL, Görtz S, Masuda K, Bugbee WD, Sah RL. Shaped, stratified, scaffold-free grafts for articular cartilage defects. Clin Orthop Relat Res. 2008 Aug; 466(8):1912-20. PMID: 18506565; PMCID: PMC2584257.
      68. Asanbaeva A, Tam J, Schumacher BL, Klisch SM, Masuda K, Sah RL. Articular cartilage tensile integrity: modulation by matrix depletion is maturation-dependent. Arch Biochem Biophys. 2008 Jun 01; 474(1):175-82. PMID: 18394422; PMCID: PMC2440786.
      69. Yamada M, Akeda K, Asanuma K, Thonar EJ, An HS, Uchida A, Masuda K. Effect of osteogenic protein-1 on the matrix metabolism of bovine tendon cells. J Orthop Res. 2008 Jan; 26(1):42-8. PMID: 17676621.
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      70. Shamji MF, Betre H, Kraus VB, Chen J, Chilkoti A, Pichika R, Masuda K, Setton LA. Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis Rheum. 2007 Nov; 56(11):3650-61. PMID: 17968946.
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      71. Patel KP, Sandy JD, Akeda K, Miyamoto K, Chujo T, An HS, Masuda K. Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration. Spine (Phila Pa 1976). 2007 Nov 01; 32(23):2596-603. PMID: 17978660.
        View in: PubMed
      72. Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL. Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network. Biomech Model Mechanobiol. 2008 Aug; 7(4):263-76. PMID: 17762943; PMCID: PMC2704288.
      73. Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL. Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile. Osteoarthritis Cartilage. 2008 Jan; 16(1):1-11. PMID: 17631390.
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      74. Alini M, Eisenstein SM, Ito K, Little C, Kettler AA, Masuda K, Melrose J, Ralphs J, Stokes I, Wilke HJ. Are animal models useful for studying human disc disorders/degeneration? Eur Spine J. 2008 Jan; 17(1):2-19. PMID: 17632738; PMCID: PMC2365516.
      75. Ficklin T, Thomas G, Barthel JC, Asanbaeva A, Thonar EJ, Masuda K, Chen AC, Sah RL, Davol A, Klisch SM. Articular cartilage mechanical and biochemical property relations before and after in vitro growth. J Biomech. 2007; 40(16):3607-14. PMID: 17628568; PMCID: PMC2175072.
      76. Chawla K, Klein TJ, Schumacher BL, Jadin KD, Shah BH, Nakagawa K, Wong VW, Chen AC, Masuda K, Sah RL. Short-term retention of labeled chondrocyte subpopulations in stratified tissue-engineered cartilaginous constructs implanted in vivo in mini-pigs. Tissue Eng. 2007 Jul; 13(7):1525-37. PMID: 17532744.
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      77. Imai Y, Miyamoto K, An HS, Thonar EJ, Andersson GB, Masuda K. Recombinant human osteogenic protein-1 upregulates proteoglycan metabolism of human anulus fibrosus and nucleus pulposus cells. Spine (Phila Pa 1976). 2007 May 20; 32(12):1303-9; discussion 1310. PMID: 17515818.
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      78. Imai Y, Okuma M, An HS, Nakagawa K, Yamada M, Muehleman C, Thonar E, Masuda K. Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC. Spine (Phila Pa 1976). 2007 May 15; 32(11):1197-205. PMID: 17495776.
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      79. Aoki Y, An HS, Takahashi K, Miyamoto K, Lenz ME, Moriya H, Masuda K. Axonal growth potential of lumbar dorsal root ganglion neurons in an organ culture system: response of nerve growth factor-sensitive neurons to neuronal injury and an inflammatory cytokine. Spine (Phila Pa 1976). 2007 Apr 15; 32(8):857-63. PMID: 17426629.
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      80. Abe Y, Akeda K, An HS, Aoki Y, Pichika R, Muehleman C, Kimura T, Masuda K. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine (Phila Pa 1976). 2007 Mar 15; 32(6):635-42. PMID: 17413467.
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      81. Akeda K, An HS, Pichika R, Patel K, Muehleman C, Nakagawa K, Uchida A, Masuda K. The expression of NG2 proteoglycan in the human intervertebral disc. Spine (Phila Pa 1976). 2007 Feb 01; 32(3):306-14. PMID: 17268261.
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      82. Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL. Mechanisms of cartilage growth: modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC. Arthritis Rheum. 2007 Jan; 56(1):188-98. PMID: 17195221.
        View in: PubMed
      83. Chiba K, Masuda K, Andersson GB, Momohara S, Thonar EJ. Matrix replenishment by intervertebral disc cells after chemonucleolysis in vitro with chondroitinase ABC and chymopapain. Spine J. 2007 Nov-Dec; 7(6):694-700. PMID: 17526432.
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      84. Chujo T, An HS, Akeda K, Miyamoto K, Muehleman C, Attawia M, Andersson G, Masuda K. Effects of growth differentiation factor-5 on the intervertebral disc--in vitro bovine study and in vivo rabbit disc degeneration model study. Spine (Phila Pa 1976). 2006 Dec 01; 31(25):2909-17. PMID: 17139221.
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      85. Miyamoto K, Masuda K, Kim JG, Inoue N, Akeda K, Andersson GB, An HS. Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs. Spine J. 2006 Nov-Dec; 6(6):692-703. PMID: 17088200.
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      86. An HS, Masuda K, Inoue N. Intervertebral disc degeneration: biological and biomechanical factors. J Orthop Sci. 2006 Oct; 11(5):541-52. PMID: 17013747; PMCID: PMC2778630.
      87. Aoki Y, Akeda K, An H, Muehleman C, Takahashi K, Moriya H, Masuda K. Nerve fiber ingrowth into scar tissue formed following nucleus pulposus extrusion in the rabbit anular-puncture disc degeneration model: effects of depth of puncture. Spine (Phila Pa 1976). 2006 Oct 01; 31(21):E774-80. PMID: 17023838.
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      88. Masuda K, An HS. Prevention of disc degeneration with growth factors. Eur Spine J. 2006 Aug; 15 Suppl 3:S422-32. PMID: 16865380; PMCID: PMC2335371.
      89. Chawla K, Klein TJ, Schumacher BL, Schmidt TA, Voegtline MS, Thonar EJ, Masuda K, Sah RL. Tracking chondrocytes and assessing their proliferation with PKH26: effects on secretion of proteoglycan 4 (PRG4). J Orthop Res. 2006 Jul; 24(7):1499-508. PMID: 16715532.
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      90. Aota Y, An HS, Imai Y, Thonar EJ, Muehleman C, Masuda K. Comparison of cellular response in bovine intervertebral disc cells and articular chondrocytes: effects .of lipopolysaccharide on proteoglycan metabolism. Cell Tissue Res. 2006 Dec; 326(3):787-93. PMID: 16788835.
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      91. Klein TJ, Schumacher BL, Blewis ME, Schmidt TA, Voegtline MS, Thonar EJ, Masuda K, Sah RL. Tailoring secretion of proteoglycan 4 (PRG4) in tissue-engineered cartilage. Tissue Eng. 2006 Jun; 12(6):1429-39. PMID: 16846341.
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      92. Li J, Jadin K, Masuda K, Sah R, Muehleman C. Characterization of lesions of the talus and description of tram-track lesions. Foot Ankle Int. 2006 May; 27(5):344-55. PMID: 16701055.
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      93. Akeda K, An HS, Pichika R, Attawia M, Thonar EJ, Lenz ME, Uchida A, Masuda K. Platelet-rich plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and anulus fibrosus cells cultured in alginate beads. Spine (Phila Pa 1976). 2006 Apr 20; 31(9):959-66. PMID: 16641770.
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      94. An HS, Masuda K. Relevance of in vitro and in vivo models for intervertebral disc degeneration. J Bone Joint Surg Am. 2006 Apr; 88 Suppl 2:88-94. PMID: 16595451.
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      95. Masuda K, Imai Y, Okuma M, Muehleman C, Nakagawa K, Akeda K, Thonar E, Andersson G, An HS. Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine (Phila Pa 1976). 2006 Apr 01; 31(7):742-54. PMID: 16582847.
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      96. Miyamoto K, Masuda K, Inoue N, Okuma M, Muehleman C, An HS. Anti-adhesion properties of a thrombin-based hemostatic gelatin in a canine laminectomy model: a biomechanical, biochemical, and histologic study. Spine (Phila Pa 1976). 2006 Feb 15; 31(4):E91-7. PMID: 16481942.
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      97. Miyamoto K, An HS, Sah RL, Akeda K, Okuma M, Otten L, Thonar EJ, Masuda K. Exposure to pulsed low intensity ultrasound stimulates extracellular matrix metabolism of bovine intervertebral disc cells cultured in alginate beads. Spine (Phila Pa 1976). 2005 Nov 01; 30(21):2398-405. PMID: 16261116.
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      98. Singh K, Masuda K, An HS. Animal models for human disc degeneration. Spine J. 2005 Nov-Dec; 5(6 Suppl):267S-279S. PMID: 16291123.
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      99. Chia SH, Homicz MR, Schumacher BL, Thonar EJ, Masuda K, Sah RL, Watson D. Characterization of human nasal septal chondrocytes cultured in alginate. J Am Coll Surg. 2005 May; 200(5):691-704. PMID: 15848359.
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      100. Takegami K, An HS, Kumano F, Chiba K, Thonar EJ, Singh K, Masuda K. Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis. Spine J. 2005 May-Jun; 5(3):231-8. PMID: 15863076.
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      101. Aota Y, An HS, Homandberg G, Thonar EJ, Andersson GB, Pichika R, Masuda K. Differential effects of fibronectin fragment on proteoglycan metabolism by intervertebral disc cells: a comparison with articular chondrocytes. Spine (Phila Pa 1976). 2005 Apr 01; 30(7):722-8. PMID: 15803072.
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      102. Masuda K, Aota Y, Muehleman C, Imai Y, Okuma M, Thonar EJ, Andersson GB, An HS. A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine (Phila Pa 1976). 2005 Jan 01; 30(1):5-14. PMID: 15626974.
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      103. An HS, Takegami K, Kamada H, Nguyen CM, Thonar EJ, Singh K, Andersson GB, Masuda K. Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits. Spine (Phila Pa 1976). 2005 Jan 01; 30(1):25-31; discussion 31-2. PMID: 15626976.
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      104. Masuda K, Oegema TR, An HS. Growth factors and treatment of intervertebral disc degeneration. Spine (Phila Pa 1976). 2004 Dec 01; 29(23):2757-69. PMID: 15564925.
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      105. Masuda K, An HS. Growth factors and the intervertebral disc. Spine J. 2004 Nov-Dec; 4(6 Suppl):330S-340S. PMID: 15541686.
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      106. Masuda K. [Tissue engineered cartilage for biological repair of cartilage defects]. Clin Calcium. 2004 Jul; 14(7):79-84. PMID: 15577081.
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      107. Zhang Y, An HS, Song S, Toofanfard M, Masuda K, Andersson GB, Thonar EJ. Growth factor osteogenic protein-1: differing effects on cells from three distinct zones in the bovine intervertebral disc. Am J Phys Med Rehabil. 2004 Jul; 83(7):515-21. PMID: 15213475.
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      108. Chia SH, Schumacher BL, Klein TJ, Thonar EJ, Masuda K, Sah RL, Watson D. Tissue-engineered human nasal septal cartilage using the alginate-recovered-chondrocyte method. Laryngoscope. 2004 Jan; 114(1):38-45. PMID: 14709992.
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      109. Williamson AK, Chen AC, Masuda K, Thonar EJ, Sah RL. Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res. 2003 Sep; 21(5):872-80. PMID: 12919876.
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      110. Klein TJ, Schumacher BL, Schmidt TA, Li KW, Voegtline MS, Masuda K, Thonar EJ, Sah RL. Tissue engineering of stratified articular cartilage from chondrocyte subpopulations. Osteoarthritis Cartilage. 2003 Aug; 11(8):595-602. PMID: 12880582.
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      111. Williamson AK, Masuda K, Thonar EJ, Sah RL. Growth of immature articular cartilage in vitro: correlated variation in tensile biomechanical and collagen network properties. Tissue Eng. 2003 Aug; 9(4):625-34. PMID: 13678441.
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      112. An HS, Thonar EJ, Masuda K. Biological repair of intervertebral disc. Spine (Phila Pa 1976). 2003 Aug 01; 28(15 Suppl):S86-92. PMID: 12897480.
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      113. Kim KW, Lim TH, Kim JG, Jeong ST, Masuda K, An HS. The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs. Spine (Phila Pa 1976). 2003 May 15; 28(10):982-90. PMID: 12768135.
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      114. Masuda K, Sah RL, Hejna MJ, Thonar EJ. A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: the alginate-recovered-chondrocyte (ARC) method. J Orthop Res. 2003 Jan; 21(1):139-48. PMID: 12507591.
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      115. Homicz MR, Chia SH, Schumacher BL, Masuda K, Thonar EJ, Sah RL, Watson D. Human septal chondrocyte redifferentiation in alginate, polyglycolic acid scaffold, and monolayer culture. Laryngoscope. 2003 Jan; 113(1):25-32. PMID: 12514377.
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      116. Kamada H, Masuda K, D'Souza AL, Lenz ME, Pietryla D, Otten L, Thonar EJ. Age-related differences in the accumulation and size of hyaluronan in alginate culture. Arch Biochem Biophys. 2002 Dec 15; 408(2):192-9. PMID: 12464271.
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      117. Cs-Szabo G, Ragasa-San Juan D, Turumella V, Masuda K, Thonar EJ, An HS. Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine (Phila Pa 1976). 2002 Oct 15; 27(20):2212-9. PMID: 12394896.
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      118. Takegami K, Thonar EJ, An HS, Kamada H, Masuda K. Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1. Spine (Phila Pa 1976). 2002 Jun 15; 27(12):1318-25. PMID: 12065981.
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      119. Qureshi AA, Virdi AS, Didonna ML, Jacobs JJ, Masuda K, Paprosky WP, Thonar EJ, Sumner DR. Implant design affects markers of bone resorption and formation in total hip replacement. J Bone Miner Res. 2002 May; 17(5):800-7. PMID: 12009010.
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