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    Dennis Carson

    TitleRecall Hcomp
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-534-5408
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Adjuvant Discovery for Vaccines against West Nile Virus and Influenza
      NIH 272201400051C-0-0-1Sep 30, 2014 - Sep 29, 2018
      Role: Principal Investigator
      Small molecule stimulators of innate immune receptors
      NIH/NIAID 272200900034C-0-0-1Sep 30, 2009 - Sep 29, 2014
      Role: Principal Investigator
      MUCOSAL IMMUNOSTIMULANTS FOR BIODEFENSE
      NIH/NIAID R21AI057436Jan 1, 2004 - Dec 31, 2005
      Role: Principal Investigator
      OPTIMIZED SYNTHETIC TLR LIGANDS FOR BIODEFENSE
      NIH/NIAID U01AI056453Jul 15, 2003 - Dec 31, 2007
      Role: Principal Investigator
      DMID CLINICAL RESEARCH OPERATIONS AND MANAGEMENT SUPPORT
      NIH N01AI000000Jul 1, 2003 - Jan 5, 2024
      Role: Principal Investigator
      Third Biennial Arthritis Research Conference
      NIH/NIAMS R13AR047878Apr 1, 2001 - Mar 31, 2002
      Role: Principal Investigator
      MOLECULAR THERAPEUTICS OF RHEUMATOID ARTHRITIS
      NIH/NIAMS P50AR044850Sep 28, 1998 - Aug 31, 2004
      Role: Principal Investigator
      CHROMOSOME 9P ABERRATIONS IN HUMAN GLIOMA
      NIH/NCI U01CA064976Feb 10, 1995 - Nov 30, 1999
      Role: Principal Investigator
      ETIOPATHOGENESIS OF RA
      NIH/NIAMS P01AR041897May 20, 1994 - Apr 30, 2000
      Role: Principal Investigator
      MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASE CENTER
      NIH/NIAMS P60AR040770Aug 1, 1991 - Feb 28, 2002
      Role: Co-Principal Investigator
      TRAINING IN CLINICAL IMMUNOLOGY
      NIH/NIAMS T32AR007567Jul 1, 1991 - May 31, 2002
      Role: Principal Investigator
      NUCLEOTIDE METABOLISM IN LYMPHOCYTES AND MACROPHAGES
      NIH/NIAID R01AI029151Sep 30, 1989 - Jul 31, 1992
      Role: Principal Investigator
      INTERNATIONAL POSTDOCTORAL RESEARCH IN AIDS
      NIH/FIC T22TW000011Jul 1, 1988 - Feb 28, 1994
      Role: Principal Investigator
      PROTECTION OF T CELLS FROM HTLV-III/LAV INFECTION
      NIH/NIAID R01AI024466Aug 1, 1987 - Jul 31, 1990
      Role: Principal Investigator
      RHEUMATOID FACTOR--GENETICS, PATHOGENESIS AND MODULATION
      NIH/NIAMS R37AR025443Sep 1, 1979 - May 31, 2000
      Role: Principal Investigator
      RHEUMATOID FACTOR: GENETICS, PATHOGENESIS, &MODULATION
      NIH/NIADDK R01AM025443Sep 1, 1979 - Aug 31, 1989
      Role: Principal Investigator
      RHEUMATOID FACTOR: GENETICS, PATHOGENESIS, &MODULATION
      NIH/NIAMS R01AR025443Sep 1, 1979 - Aug 31, 1989
      Role: Principal Investigator
      Specialized Cancer Center Support Grant
      NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2019
      Role: Co-Principal Investigator
      REGULATION OF SENESCENCE AND APOPTOSIS IN LYMPHOCYTES
      NIH/NIGMS R01GM023200Jun 30, 1976 - Jan 31, 2005
      Role: Principal Investigator
      TRAINING IN MOLECULAR ASPECTS OF CLINICAL IMMUNOLOGY
      NIH/NIAMS T32AR007144Jul 1, 1975 - Apr 30, 1998
      Role: Co-Principal Investigator
      TRAINING IN CLINICAL IMMUNOLOGY
      NIH/NIADDK T32AM007144Jul 1, 1975 - Jun 30, 1990
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson D, Hayashi T, Cohen EE. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 Sep 21; 2(18). PMID: 28931759.
        View in: PubMed
      2. Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson D, Palese P, Corr M. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice. J Virol. 2017 Oct 01; 91(19). PMID: 28724768.
        View in: PubMed
      3. Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson D, Cottam HB, Shukla NM. Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-?B Activation without Intrinsic Activity. ACS Comb Sci. 2017 Aug 14; 19(8):533-543. PMID: 28657707.
        View in: PubMed
      4. Griffin JI, Cheng SKK, Hayashi T, Carson D, Saraswathy M, Nair DP, Simberg D. Cell-penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury. Nanomedicine. 2017 Apr 17; 13(6):1925-1932. PMID: 28428051.
        View in: PubMed
      5. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson D, Guan KL. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. PMID: 27912060.
        View in: PubMed
      6. Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson D, Lu D. Prodigiosin inhibits Wnt/ß-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46):13150-13155. PMID: 27799526.
        View in: PubMed
      7. Bram Z, Louiset E, Ragazzon B, Renouf S, Wils J, Duparc C, Boutelet I, Rizk-Rabin M, Libé R, Young J, Carson D, Vantyghem MC, Szarek E, Martinez A, Stratakis CA, Bertherat J, Lefebvre H. PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease. JCI Insight. 2016 Sep 22; 1(15):e87958. PMID: 27699247.
        View in: PubMed
      8. Schwab RB, Kato S, Crain B, Pu M, Messer K, Weidner N, Blair SL, Wallace AM, Carson D, Parker BA. A window-of-opportunity biomarker study of etodolac in resectable breast cancer. Cancer Med. 2015 Oct; 4(10):1583-8. PMID: 26275572; PMCID: PMC4618628.
      9. Shinchi H, Crain B, Yao S, Chan M, Zhang SS, Ahmadiiveli A, Suda Y, Hayashi T, Cottam HB, Carson D. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19; 26(8):1713-23. PMID: 26193334.
        View in: PubMed
      10. Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam HB, Carson D, Corr M. Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes. PLoS One. 2015; 10(6):e0129867. PMID: 26076454; PMCID: PMC4468074.
      11. Choi MY, Widhopf GF, Wu CC, Cui B, Lao F, Sadarangani A, Cavagnaro J, Prussak C, Carson D, Jamieson C, Kipps TJ. Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15 Suppl:S167-9. PMID: 26297272; PMCID: PMC4548279.
      12. Barrett CL, DeBoever C, Jepsen K, Saenz CC, Carson D, Frazer KA. Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):E3050-7. PMID: 26015570; PMCID: PMC4466751.
      13. Smith EN, Ghia EM, DeBoever CM, Rassenti LZ, Jepsen K, Yoon KA, Matsui H, Rozenzhak S, Alakus H, Shepard PJ, Dai Y, Khosroheidari M, Bina M, Gunderson KL, Messer K, Muthuswamy L, Hudson TJ, Harismendy O, Barrett CL, Jamieson CH, Carson D, Kipps TJ, Frazer KA. Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development. Blood Cancer J. 2015 Apr 10; 5:e303. PMID: 25860294; PMCID: PMC4450323.
      14. DeBoever C, Ghia EM, Shepard PJ, Rassenti L, Barrett CL, Jepsen K, Jamieson CH, Carson D, Kipps TJ, Frazer KA. Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers. PLoS Comput Biol. 2015 Mar; 11(3):e1004105. PMID: 25768983; PMCID: PMC4358997.
      15. Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson D. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015 Mar; 89(6):3221-35. PMID: 25568203; PMCID: PMC4337541.
      16. Zhang S, Cui B, Lai H, Liu G, Ghia EM, Widhopf GF, Zhang Z, Wu CC, Chen L, Wu R, Schwab R, Carson D, Kipps TJ. Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17266-71. PMID: 25411317; PMCID: PMC4260559.
      17. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson D, Cottam HB. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. PMID: 25288184; PMCID: PMC4250372.
      18. Saenz R, Futalan D, Leutenez L, Eekhout F, Fecteau JF, Sundelius S, Sundqvist S, Larsson M, Hayashi T, Minev B, Carson D, Esener S, Messmer B, Messmer D. TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant. J Transl Med. 2014 Aug 14; 12:211. PMID: 25123824; PMCID: PMC4261565.
      19. Smith EN, Jepsen K, Khosroheidari M, Rassenti LZ, D'Antonio M, Ghia EM, Carson D, Jamieson CH, Kipps TJ, Frazer KA. Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments. Genome Biol. 2014 Aug 07; 15(8):420. PMID: 25103687; PMCID: PMC4165357.
      20. Baghdadchi S, Liu K, Knapp J, Prager G, Graves S, Akrami K, Manuel R, Bastos R, Reid E, Carson D, Esener S, Carson J, Liu YT. An innovative system for 3D clinical photography in the resource-limited settings. J Transl Med. 2014 Jun 15; 12:169. PMID: 24929434; PMCID: PMC4065604.
      21. Hayashi T, Crain B, Yao S, Caneda CD, Cottam HB, Chan M, Corr M, Carson D. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014 Aug; 350(2):330-40. PMID: 24893985; PMCID: PMC4109491.
      22. Fernandez A, Huggins IJ, Perna L, Brafman D, Lu D, Yao S, Gaasterland T, Carson D, Willert K. The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1409-14. PMID: 24474766; PMCID: PMC3910637.
      23. Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson D, Hayashi T. Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand. J Innate Immun. 2014; 6(3):315-24. PMID: 24192551; PMCID: PMC3972367.
      24. Crain B, Yao S, Keophilaone V, Promessi V, Kang M, Barberis A, Maj R, Mura E, Passini N, Holldack J, Ochoa R, Cottam HB, Carson D, Hayashi T. Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. Eur J Dermatol. 2013 Sep-Oct; 23(5):618-28. PMID: 24225049; PMCID: PMC3959874.
      25. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson D, Cottam HB. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. PMID: 23656327; PMCID: PMC3722616.
      26. Barrett CL, Schwab RB, Jung H, Crain B, Goff DJ, Jamieson CH, Thistlethwaite PA, Harismendy O, Carson D, Frazer KA. Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. PLoS One. 2013; 8(3):e58714. PMID: 23527012; PMCID: PMC3604164.
      27. Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam HB, Carson D, Corr M. Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. PLoS One. 2012; 7(9):e45860. PMID: 23029281; PMCID: PMC3461028.
      28. Wu RP, Li H, Rassenti LZ, Hayashi T, Wu CN, Kipps TJ, Messer K, Carson D. Increased aldehyde dehydrogenase activity in high-risk chronic lymphocytic leukemia. Leuk Lymphoma. 2013 Feb; 54(2):400-2. PMID: 22784365; PMCID: PMC3821178.
      29. Pu M, Hayashi T, Cottam H, Mulvaney J, Arkin M, Corr M, Carson D, Messer K. Analysis of high-throughput screening assays using cluster enrichment. Stat Med. 2012 Dec 30; 31(30):4175-89. PMID: 22763983; PMCID: PMC3635947.
      30. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson D, Look AT, Jamieson CH. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. PMID: 22768113; PMCID: PMC3387267.
      31. Norton JT, Hayashi T, Crain B, Cho JS, Miller LS, Corr M, Carson D. Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1. J Immunol. 2012 Apr 01; 188(7):2977-80. PMID: 22387558; PMCID: PMC3311728.
      32. Kim Y, Gast SM, Endo T, Lu D, Carson D, Schmidt-Wolf IG. In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma. Leuk Res. 2012 May; 36(5):598-600. PMID: 22386728.
        View in: PubMed
      33. Hayashi T, Yao S, Crain B, Chan M, Cottam HB, Lao F, Carson D, Corr M. Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand. Mediators Inflamm. 2012; 2012:262394. PMID: 22619481; PMCID: PMC3348532.
      34. Kim Y, Schmidt M, Endo T, Lu D, Carson D, Schmidt-Wolf IG. Targeting the Wnt/beta-catenin pathway with the antifungal agent ciclopirox olamine in a murine myeloma model. In Vivo. 2011 Nov-Dec; 25(6):887-93. PMID: 22021681.
        View in: PubMed
      35. Shi L, Ramsay S, Ermis R, Carson D. In vitro and in vivo studies on matrix metalloproteinases interacting with small intestine submucosa wound matrix. Int Wound J. 2012 Feb; 9(1):44-53. PMID: 21883934.
        View in: PubMed
      36. Zinkernagel AS, Hruz P, Uchiyama S, von Köckritz-Blickwede M, Schuepbach RA, Hayashi T, Carson D, Nizet V. Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections. J Innate Immun. 2012; 4(2):213-8. PMID: 21860217; PMCID: PMC3388268.
      37. Lu D, Carson D. Inhibition of Wnt signaling and cancer stem cells. Oncotarget. 2011 Aug; 2(8):587. PMID: 21860066; PMCID: PMC3248212.
      38. Lu D, Choi MY, Yu J, Castro JE, Kipps TJ, Carson D. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13253-7. PMID: 21788521; PMCID: PMC3156152.
      39. Nicolaou KC, Ellery SP, Rivas F, Saye K, Rogers E, Workinger TJ, Schallenberger M, Tawatao R, Montero A, Hessell A, Romesberg F, Carson D, Burton D. Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues. Bioorg Med Chem. 2011 Sep 15; 19(18):5648-69. PMID: 21840722; PMCID: PMC3348725.
      40. Norton JT, Hayashi T, Crain B, Corr M, Carson D. Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11163-8. PMID: 21690387; PMCID: PMC3131380.
      41. Schmidt M, Kim Y, Gast SM, Endo T, Lu D, Carson D, Schmidt-Wolf IG. Increased in vivo efficacy of lenalidomide and thalidomide by addition of ethacrynic acid. In Vivo. 2011 May-Jun; 25(3):325-33. PMID: 21576405.
        View in: PubMed
      42. Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, Tawatao RI, Kalenian K, Zhang Y, Hayashi Y, Lao FS, Cottam HB, Carson D. Synthesis and characterization of PEGylated toll like receptor 7 ligands. Bioconjug Chem. 2011 Mar 16; 22(3):445-54. PMID: 21338093; PMCID: PMC3063487.
      43. Kim Y, Reifenberger G, Lu D, Endo T, Carson D, Gast SM, Meschenmoser K, Nowak M, Schmidt-Wolf IG. Influencing the Wnt signaling pathway in multiple myeloma. Anticancer Res. 2011 Feb; 31(2):725-30. PMID: 21378363.
        View in: PubMed
      44. Hayashi T, Chan M, Norton JT, Wu CC, Yao S, Cottam HB, Tawatao RI, Corr M, Carson D, Daniels GA. Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2. Melanoma Res. 2011 Feb; 21(1):66-75. PMID: 21030882.
        View in: PubMed
      45. Kim Y, Alpmann P, Blaum-Feder S, Krämer S, Endo T, Lu D, Carson D, Schmidt-Wolf IG. Increased in vivo efficacy of lenalidomide by addition of piroctone olamine. In Vivo. 2011 Jan-Feb; 25(1):99-103. PMID: 21282741.
        View in: PubMed
      46. Kim Y, Alpmann P, Blaum-Feder S, Krämer S, Endo T, Lu D, Carson D, Schmidt-Wolf IG. In vivo efficacy of griseofulvin against multiple myeloma. Leuk Res. 2011 Aug; 35(8):1070-3. PMID: 21112630.
        View in: PubMed
      47. Zhang Y, Elliot G, Saldanha A, Tsigelny I, Carson D, Wrasidlo W. Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid. Beilstein J Org Chem. 2010 Sep 01; 6:742-7. PMID: 20978615; PMCID: PMC2956464.
      48. Wu RP, Hayashi T, Cottam HB, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab RB, Carson D. Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7479-84. PMID: 20368435; PMCID: PMC2867719.
      49. Lu D, Carson D. Repression of beta-catenin signaling by PPAR gamma ligands. Eur J Pharmacol. 2010 Jun 25; 636(1-3):198-202. PMID: 20303941; PMCID: PMC2866743.
      50. Hayashi T, Crain B, Corr M, Chan M, Cottam HB, Maj R, Barberis A, Leoni L, Carson D. Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. Int J Urol. 2010 May; 17(5):483-90. PMID: 20337728; PMCID: PMC3876967.
      51. Bashir A, Lu Q, Carson D, Raphael BJ, Liu YT, Bafna V. Optimizing PCR assays for DNA-based cancer diagnostics. J Comput Biol. 2010 Mar; 17(3):369-81. PMID: 20377451; PMCID: PMC3213025.
      52. Lu D, Liu JX, Endo T, Zhou H, Yao S, Willert K, Schmidt-Wolf IG, Kipps TJ, Carson D. Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14; 4(12):e8294. PMID: 20011538; PMCID: PMC2789382.
      53. Lu D, Carson D. Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. BMC Pharmacol. 2009 Nov 30; 9:13. PMID: 19948059; PMCID: PMC2789054.
      54. Yang D, Pornpattananangkul D, Nakatsuji T, Chan M, Carson D, Huang CM, Zhang L. The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. Biomaterials. 2009 Oct; 30(30):6035-40. PMID: 19665786; PMCID: PMC2735618.
      55. Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, Corr M, Wrasidlo W, Cottam HB, Carson D. Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem. 2009 Jun; 20(6):1194-200. PMID: 19445505; PMCID: PMC2976567.
      56. Hayashi T, Gray CS, Chan M, Tawatao RI, Ronacher L, McGargill MA, Datta SK, Carson D, Corr M. Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2764-9. PMID: 19188597; PMCID: PMC2634806.
      57. Jin G, Lu D, Yao S, Wu CC, Liu JX, Carson D, Cottam HB. Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):606-9. PMID: 19121941.
        View in: PubMed
      58. Schmidt M, Sievers E, Endo T, Lu D, Carson D, Schmidt-Wolf IG. Targeting Wnt pathway in lymphoma and myeloma cells. Br J Haematol. 2009 Mar; 144(5):796-8. PMID: 19036118.
        View in: PubMed
      59. Lu Q, Nunez E, Lin C, Christensen K, Downs T, Carson D, Wang-Rodriguez J, Liu YT. A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variants. Nucleic Acids Res. 2008 Nov; 36(20):e130. PMID: 18794177; PMCID: PMC2582611.
      60. Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson D, Guiney DG, Corr M. In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell Immunol. 2008 Feb; 251(2):78-85. PMID: 18495099; PMCID: PMC4012540.
      61. Hayashi T, Cottam HB, Chan M, Jin G, Tawatao RI, Crain B, Ronacher L, Messer K, Carson D, Corr M. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R123-32. PMID: 18480244; PMCID: PMC2494819.
      62. Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE, Widhopf GF, Rassenti LZ, Cantwell MJ, Prussak CE, Carson D, Kipps TJ. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):3047-52. PMID: 18287027; PMCID: PMC2268582.
      63. Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson D, Stupack DG. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2313-8. PMID: 18268346; PMCID: PMC2268133.
      64. Livengood AJ, Wu CC, Carson D. Opposing roles of RNA receptors TLR3 and RIG-I in the inflammatory response to double-stranded RNA in a Kaposi's sarcoma cell line. Cell Immunol. 2007 Oct; 249(2):55-62. PMID: 18155685; PMCID: PMC2262282.
      65. Bashir A, Liu YT, Raphael BJ, Carson D, Bafna V. Optimization of primer design for the detection of variable genomic lesions in cancer. Bioinformatics. 2007 Nov 01; 23(21):2807-15. PMID: 17766270.
        View in: PubMed
      66. Liu YT, Carson D. A novel approach for determining cancer genomic breakpoints in the presence of normal DNA. PLoS One. 2007 Apr 18; 2(4):e380. PMID: 17440616; PMCID: PMC1847701.
      67. Wu CC, Hayashi T, Takabayashi K, Sabet M, Smee DF, Guiney DD, Cottam HB, Carson D. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3990-5. PMID: 17360465; PMCID: PMC1820696.
      68. Jin G, Wu CC, Tawatao RI, Chan M, Carson D, Cottam HB. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. Bioorg Med Chem Lett. 2006 Sep 01; 16(17):4559-63. PMID: 16784848.
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      69. Castro JE, Prada CE, Aguillon RA, Kitada S, Fukuda T, Motta M, Wu C, Dicker F, Sun G, Wang JY, Carson D, Reed JC, Kipps TJ. Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference. Leukemia. 2006 Apr; 20(4):680-8. PMID: 16498393.
        View in: PubMed
      70. Barnard DL, Day CW, Bailey K, Heiner M, Montgomery R, Lauridsen L, Winslow S, Hoopes J, Li JK, Lee J, Carson D, Cottam HB, Sidwell RW. Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral Res. 2006 Aug; 71(1):53-63. PMID: 16621037.
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      71. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson D. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1828-33. PMID: 16446426; PMCID: PMC1413670.
      72. Jin G, Wu CC, Carson D, Cottam HB. Guanosine analog in the pyrido[2,3-d]pyrimidine ring system as a potential toll-like receptor agonist. Nucleosides Nucleotides Nucleic Acids. 2006; 25(12):1391-7. PMID: 17067960.
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      73. Lu D, Cottam HB, Corr M, Carson D. Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18567-71. PMID: 16352713; PMCID: PMC1317972.
      74. Barchéchath SD, Tawatao RI, Corr M, Carson D, Cottam HB. Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. J Med Chem. 2005 Oct 06; 48(20):6409-22. PMID: 16190767.
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      75. Holderbaum D, Malvitz T, Ciesielski CJ, Carson D, Corr MP, Moskowitz RW. A newly described hereditary cartilage debonding syndrome. Arthritis Rheum. 2005 Oct; 52(10):3300-4. PMID: 16200603.
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      76. Barchéchath SD, Tawatao RI, Corr M, Carson D, Cottam HB. Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. Bioorg Med Chem Lett. 2005 Apr 01; 15(7):1785-8. PMID: 15780606.
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      77. Kolluri SK, Corr M, James SY, Bernasconi M, Lu D, Liu W, Cottam HB, Leoni LM, Carson D, Zhang XK. The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2525-30. PMID: 15699354; PMCID: PMC548323.
      78. Ohata J, Zvaifler NJ, Nishio M, Boyle DL, Kalled SL, Carson D, Kipps TJ. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol. 2005 Jan 15; 174(2):864-70. PMID: 15634908.
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      79. Diccianni MB, Yu J, Meppelink G, de Vries M, Shao L, Gebauer S, Shih H, Roberts W, Kilcoin NP, Pullen J, Carson D, Yu AL. 3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner. J Exp Ther Oncol. 2004 Oct; 4(3):223-37. PMID: 15724842.
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      80. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide DH, Carson D, Raz E. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 2004 Jul; 114(2):270-9. PMID: 15254594; PMCID: PMC449749.
      81. Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, Ferreira A, Ciesielski C, Carson D, Corr M. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9757-62. PMID: 15210948; PMCID: PMC470747.
      82. Wu CC, Lee J, Raz E, Corr M, Carson D. Necessity of oligonucleotide aggregation for toll-like receptor 9 activation. J Biol Chem. 2004 Aug 06; 279(32):33071-8. PMID: 15184382.
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      83. Hedvat M, Jain A, Carson D, Leoni LM, Huang G, Holden S, Lu D, Corr M, Fox W, Agus DB. Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma. Cancer Cell. 2004 Jun; 5(6):565-74. PMID: 15193259.
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      84. Lu D, Zhao Y, Tawatao R, Cottam HB, Sen M, Leoni LM, Kipps TJ, Corr M, Carson D. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3118-23. PMID: 14973184; PMCID: PMC365753.
      85. Sen M, Cheng YH, Goldring MB, Lotz MK, Carson D. WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum. 2004 Feb; 50(2):488-97. PMID: 14872491.
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      86. Adachi S, Leoni LM, Carson D, Nakahata T. Apoptosis induced by molecular targeting therapy in hematological malignancies. Acta Haematol. 2004; 111(1-2):107-23. PMID: 14646349.
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      87. Silverman GJ, Carson D. Roles of B cells in rheumatoid arthritis. Arthritis Res Ther. 2003; 5 Suppl 4:S1-6. PMID: 15180890; PMCID: PMC2833442.
      88. Wu CC, Castro JE, Motta M, Cottam HB, Kyburz D, Kipps TJ, Corr M, Carson D. Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells. Hum Gene Ther. 2003 Jun 10; 14(9):849-60. PMID: 12828856.
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      89. Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson D, Raz E, Cottam HB. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6646-51. PMID: 12738885; PMCID: PMC164501.
      90. Kyburz D, Rethage J, Seibl R, Lauener R, Gay RE, Carson D, Gay S. Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling. Arthritis Rheum. 2003 Mar; 48(3):642-50. PMID: 12632416.
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      91. Carson D, Leoni LM. Hairy-cell leukaemia as a model for drug development. Best Pract Res Clin Haematol. 2003 Mar; 16(1):83-9. PMID: 12670467.
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      92. Sen M, Reifert J, Lauterbach K, Wolf V, Rubin JS, Corr M, Carson D. Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum. 2002 Nov; 46(11):2867-77. PMID: 12428226.
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      93. Rhee CS, Sen M, Lu D, Wu C, Leoni L, Rubin J, Corr M, Carson D. Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene. 2002 Sep 26; 21(43):6598-605. PMID: 12242657.
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      94. Shih H, Cottam HB, Carson D. Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors. Chem Pharm Bull (Tokyo). 2002 Mar; 50(3):364-7. PMID: 11911199.
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      95. Sen M, Carson D. Wnt signaling in rheumatoid synoviocyte activation. Mod Rheumatol. 2002 Mar; 12(1):5-9. PMID: 24383825.
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      96. Ronaghy A, Prakken BJ, Takabayashi K, Firestein GS, Boyle D, Zvailfler NJ, Roord ST, Albani S, Carson D, Raz E. Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol. 2002 Jan 01; 168(1):51-6. PMID: 11751945.
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      97. Van Uden JH, Tran CH, Carson D, Raz E. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol. 2001 Nov; 31(11):3281-90. PMID: 11745345.
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      98. Hayashi T, Rao SP, Takabayashi K, Van Uden JH, Kornbluth RS, Baird SM, Taylor MW, Carson D, Catanzaro A, Raz E. Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase. Infect Immun. 2001 Oct; 69(10):6156-64. PMID: 11553555; PMCID: PMC98746.
      99. Hua XH, Genini D, Gussio R, Tawatao R, Shih H, Kipps TJ, Carson D, Leoni LM. Biochemical genetic analysis of indanocine resistance in human leukemia. Cancer Res. 2001 Oct 01; 61(19):7248-54. PMID: 11585762.
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      100. Uchijima M, Raz E, Carson D, Nagata T, Koide Y. Identification of immunostimulatory DNA-induced genes by suppression subtractive hybridization. Biochem Biophys Res Commun. 2001 Aug 31; 286(4):688-91. PMID: 11520051.
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      101. Sen M, Chamorro M, Reifert J, Corr M, Carson D. Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheum. 2001 Apr; 44(4):772-81. PMID: 11315916.
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      102. Prakken BJ, Carson D, Albani S. T cell repertoire formation and molecular mimicry in rheumatoid arthritis. Curr Dir Autoimmun. 2001; 3:51-63. PMID: 11791471.
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      103. Schmid M, Sen M, Rosenbach MD, Carrera CJ, Friedman H, Carson D. A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. Oncogene. 2000 Nov 23; 19(50):5747-54. PMID: 11126361.
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      104. Genini D, Adachi S, Chao Q, Rose DW, Carrera CJ, Cottam HB, Carson D, Leoni LM. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood. 2000 Nov 15; 96(10):3537-43. PMID: 11071652.
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      105. Suh SI, Pyun HY, Cho JW, Baek WK, Park JB, Kwon T, Park JW, Suh MH, Carson D. 5-Aza-2'-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular carcinoma cell lines. Cancer Lett. 2000 Nov 10; 160(1):81-8. PMID: 11098088.
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      106. Genini D, Sheeter D, Rought S, Zaunders JJ, Susin SA, Kroemer G, Richman DD, Carson D, Corbeil J, Leoni LM. HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism. FASEB J. 2001 Jan; 15(1):5-6. PMID: 11099484.
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      107. Kyburz D, Carson D, Corr M. The role of CD40 ligand and tumor necrosis factor alpha signaling in the transgenic K/BxN mouse model of rheumatoid arthritis. Arthritis Rheum. 2000 Nov; 43(11):2571-7. PMID: 11083282.
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      108. Suh SI, Cho JW, Baek WK, Suh MH, Carson D. Lack of mutation at p16INK4A gene but expression of aberrant p16INK4A RNA transcripts in human ovarian carcinoma. Cancer Lett. 2000 May 29; 153(1-2):175-82. PMID: 10779647.
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      109. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M, Carson D. Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2791-6. PMID: 10688908; PMCID: PMC16008.
      110. Shih H, Deng L, Carrera CJ, Adachi S, Cottam HB, Carson D. Rational design, synthesis and structure-activity relationships of antitumor (E)-2-benzylidene-1-tetralones and (E)-2-benzylidene-1-indanones. Bioorg Med Chem Lett. 2000 Mar 06; 10(5):487-90. PMID: 10743954.
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      111. Leoni LM, Hamel E, Genini D, Shih H, Carrera CJ, Cottam HB, Carson D. Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells. J Natl Cancer Inst. 2000 Feb 02; 92(3):217-24. PMID: 10655438.
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      112. Genini D, Budihardjo I, Plunkett W, Wang X, Carrera CJ, Cottam HB, Carson D, Leoni LM. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. J Biol Chem. 2000 Jan 07; 275(1):29-34. PMID: 10617581.
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      113. Bonnin D, Prakken B, Samodal R, La Cava A, Carson D, Albani S. Ontogeny of synonymous T cell populations with specificity for a self MHC epitope mimicked by a bacterial homologoue: an antigen-specific T cell analysis in a non-transgenic system. Eur J Immunol. 1999 Dec; 29(12):3826-36. PMID: 10601990.
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      114. Chao Q, Deng L, Shih H, Leoni LM, Genini D, Carson D, Cottam HB. Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. J Med Chem. 1999 Sep 23; 42(19):3860-73. PMID: 10508435.
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      115. Kyburz D, Corr M, Brinson DC, Von Damm A, Tighe H, Carson D. Human rheumatoid factor production is dependent on CD40 signaling and autoantigen. J Immunol. 1999 Sep 15; 163(6):3116-22. PMID: 10477577.
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      116. Carson D, Haneji N. Fighting arthritis with a senescence gene. Nat Med. 1999 Jul; 5(7):731-2. PMID: 10395310.
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      117. Chukwuocha RU, Zhang B, Lai CJ, Scavulli JF, Albani S, Carson D, Chen PP. Isolation of an IgG monoclonal anti-dnaJ antibody from an immunoglobulin combinatorial library from a patient with rheumatoid arthritis. J Rheumatol. 1999 Jul; 26(7):1439-45. PMID: 10405927.
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      118. Brat DJ, James CD, Jedlicka AE, Connolly DC, Chang E, Castellani RJ, Schmid M, Schiller M, Carson D, Burger PC. Molecular genetic alterations in radiation-induced astrocytomas. Am J Pathol. 1999 May; 154(5):1431-8. PMID: 10329596; PMCID: PMC1866591.
      119. Warnatz K, Kyburz D, Brinson DC, Lee DJ, Von Damm A, Engelhart M, Corr M, Carson D, Tighe H. Rheumatoid factor B cell tolerance via autonomous Fas/FasL-independent apoptosis. Cell Immunol. 1999 Jan 10; 191(1):69-73. PMID: 9918688.
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      120. Schmid M, Malicki D, Nobori T, Rosenbach MD, Campbell K, Carson D, Carrera CJ. Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC). Oncogene. 1998 Nov 19; 17(20):2669-75. PMID: 9840931.
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      121. Kohsaka H, Carson D, Miyasaka N. Formation of peripheral immunoreceptor repertoire for antigens: potential relationship to the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 1998 Nov; 41(11):1911-8. PMID: 9811044.
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      122. Lee DJ, Corr M, Carson D. Control of immune responses by gene immunization. Ann Med. 1998 Oct; 30(5):460-8. PMID: 9814832.
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      123. Leoni LM, Chao Q, Cottam HB, Genini D, Rosenbach M, Carrera CJ, Budihardjo I, Wang X, Carson D. Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9567-71. PMID: 9689121; PMCID: PMC21379.
      124. Carson D. An infectious origin of extraskeletal calcification. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):7846-7. PMID: 9653101; PMCID: PMC33867.
      125. Leoni LM, Shih HC, Deng L, Tuey C, Walter G, Carson D, Cottam HB. Modulation of ceramide-activated protein phosphatase 2A activity by low molecular weight aromatic compounds. Biochem Pharmacol. 1998 Apr 01; 55(7):1105-11. PMID: 9605434.
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      126. Lee DJ, Abeyratne A, Carson D, Corr M. Induction of an antigen-specific, CD1-restricted cytotoxic T lymphocyte response In vivo. J Exp Med. 1998 Feb 02; 187(3):433-8. PMID: 9449723; PMCID: PMC2212129.
      127. Hori Y, Hori H, Yamada Y, Carrera CJ, Tomonaga M, Kamihira S, Carson D, Nobori T. The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia. Int J Cancer. 1998 Jan 05; 75(1):51-6. PMID: 9426690.
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      128. Mizushima N, Kohsaka H, Nanki T, Ollier WE, Carson D, Miyasaka N. HLA-dependent peripheral T cell receptor (TCR) repertoire formation and its modification by rheumatoid arthritis (RA) Clin Exp Immunol. 1997 Dec; 110(3):428-33. PMID: 9409647; PMCID: PMC1904832.
      129. Carson D, Raz E. Oligonucleotide adjuvants for T helper 1 (Th1)-specific vaccination. J Exp Med. 1997 Nov 17; 186(10):1621-2. PMID: 9411016; PMCID: PMC2199144.
      130. Croy BA, Ashkar AA, Foster RA, DiSanto JP, Magram J, Carson D, Gendler SJ, Grusby MJ, Wagner N, Muller W, Guimond MJ. Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy. J Reprod Immunol. 1997 Nov 15; 35(2):111-33. PMID: 9421796.
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      131. Corr M, Tighe H, Lee D, Dudler J, Trieu M, Brinson DC, Carson D. Costimulation provided by DNA immunization enhances antitumor immunity. J Immunol. 1997 Nov 15; 159(10):4999-5004. PMID: 9366427.
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      132. Lee KS, Cottam HB, Houglum K, Wasson DB, Carson D, Chojkier M. Pentoxifylline blocks hepatic stellate cell activation independently of phosphodiesterase inhibitory activity. Am J Physiol. 1997 Nov; 273(5 Pt 1):G1094-100. PMID: 9374707.
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      133. Cho CS, Wang X, Zhao Y, Carson D, Chen PP. Genotyping by PCR-ELISA of a complex polymorphic region that contains one to four copies of six highly homologous human VH3 genes. Proc Assoc Am Physicians. 1997 Nov; 109(6):558-64. PMID: 9394417.
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      134. Perry A, Nobori T, Ru N, Anderl K, Borell TJ, Mohapatra G, Feuerstein BG, Jenkins RB, Carson D. Detection of p16 gene deletions in gliomas: a comparison of fluorescence in situ hybridization (FISH) versus quantitative PCR. J Neuropathol Exp Neurol. 1997 Sep; 56(9):999-1008. PMID: 9291941.
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      135. La Cava A, Nelson JL, Ollier WE, MacGregor A, Keystone EC, Thorne JC, Scavulli JF, Berry CC, Carson D, Albani S. Genetic bias in immune responses to a cassette shared by different microorganisms in patients with rheumatoid arthritis. J Clin Invest. 1997 Aug 01; 100(3):658-63. PMID: 9239413; PMCID: PMC508234.
      136. Roman M, Martin-Orozco E, Goodman JS, Nguyen MD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson D, Raz E. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med. 1997 Aug; 3(8):849-54. PMID: 9256274.
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      137. Lee DJ, Tighe H, Corr M, Roman M, Carson D, Spiegelberg HL, Raz E. Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells. Int Arch Allergy Immunol. 1997 May-Jul; 113(1-3):227-30. PMID: 9130530.
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      138. Tran PT, Hori H, Hori Y, Okumura K, Kagotani K, Taguchi H, Carson D, Nobori T. Molecular cloning of the human methylthioadenosine phosphorylase processed pseudogene and localization to 3q28. Gene. 1997 Feb 28; 186(2):263-9. PMID: 9074505.
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      139. Carson D. Unconventional T-cell activation by IL-15 in rheumatoid arthritis. Nat Med. 1997 Feb; 3(2):148-9. PMID: 9018227.
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      140. Tighe H, Warnatz K, Brinson D, Corr M, Weigle WO, Baird SM, Carson D. Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):646-51. PMID: 9012838; PMCID: PMC19567.
      141. Yang YY, Fischer P, Leu SJ, Olee T, Carson D, Chen PP. IgG rheumatoid factors isolated by the surface-displaying phage library technique. Immunogenetics. 1997; 45(5):301-10. PMID: 9038102.
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      142. Hori H, Tran P, Carrera CJ, Hori Y, Rosenbach MD, Carson D, Nobori T. Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells. Cancer Res. 1996 Dec 15; 56(24):5653-8. PMID: 8971171.
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      143. Kohsaka H, Carson D, Rassenti LZ, Ollier WE, Chen PP, Kipps TJ, Miyasaka N. The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation. J Clin Invest. 1996 Dec 15; 98(12):2794-800. PMID: 8981926; PMCID: PMC507745.
      144. Nanki T, Kohsaka H, Mizushima N, Ollier WE, Carson D, Miyasaka N. Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins. J Clin Invest. 1996 Oct 01; 98(7):1594-601. PMID: 8833908; PMCID: PMC507592.
      145. Albani S, Carson D. A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis. Immunol Today. 1996 Oct; 17(10):466-70. PMID: 8908811.
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      146. Corr M, Lee DJ, Carson D, Tighe H. Gene vaccination with naked plasmid DNA: mechanism of CTL priming. J Exp Med. 1996 Oct 01; 184(4):1555-60. PMID: 8879229; PMCID: PMC2192808.
      147. England NL, Cuthbert AP, Trott DA, Jezzard S, Nobori T, Carson D, Newbold RF. Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16INK4A). Carcinogenesis. 1996 Aug; 17(8):1567-75. PMID: 8761411.
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      148. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen MD, Silverman GJ, Lotz M, Carson D, Raz E. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science. 1996 Jul 19; 273(5273):352-4. PMID: 8662521.
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      149. Kohsaka H, Nanki T, Ollier WE, Miyasaka N, Carson D. Influence of the rheumatoid arthritis-associated shared epitope on T-cell receptor repertoire formation. Proc Assoc Am Physicians. 1996 Jul; 108(4):323-8. PMID: 8863346.
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      150. Della Ragione F, Takabayashi K, Mastropietro S, Mercurio C, Oliva A, Russo GL, Della Pietra V, Borriello A, Nobori T, Carson D, Zappia V. Purification and characterization of recombinant human 5'-methylthioadenosine phosphorylase: definite identification of coding cDNA. Biochem Biophys Res Commun. 1996 Jun 25; 223(3):514-9. PMID: 8687427.
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      151. Nobori T, Takabayashi K, Tran P, Orvis L, Batova A, Yu AL, Carson D. Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):6203-8. PMID: 8650244; PMCID: PMC39214.
      152. Raz E, Tighe H, Sato Y, Corr M, Dudler JA, Roman M, Swain SL, Spiegelberg HL, Carson D. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):5141-5. PMID: 8643542; PMCID: PMC39421.
      153. Hori H, Takabayashi K, Orvis L, Carson D, Nobori T. Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase. Cancer Res. 1996 May 01; 56(9):2116-22. PMID: 8616859.
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      154. Krawczynski K, Alter MJ, Tankersley DL, Beach M, Robertson BH, Lambert S, Kuo G, Spelbring JE, Meeks E, Sinha S, Carson D. Effect of immune globulin on the prevention of experimental hepatitis C virus infection. J Infect Dis. 1996 Apr; 173(4):822-8. PMID: 8603959.
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      155. Cottam HB, Shih H, Tehrani LR, Wasson DB, Carson D. Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. J Med Chem. 1996 Jan 05; 39(1):2-9. PMID: 8568809.
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      156. Eibschutz B, Baird SM, Weisman MH, Amox DG, Spellman M, Piacquadio D, Carrera CJ, Carson D. Oral 2-chlorodeoxyadenosine in psoriatic arthritis. A preliminary report. Arthritis Rheum. 1995 Nov; 38(11):1604-9. PMID: 7488281.
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      157. Carson D, Lois A. Cancer progression and p53. Lancet. 1995 Oct 14; 346(8981):1009-11. PMID: 7475551.
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      158. Lois AF, Cooper LT, Geng Y, Nobori T, Carson D. Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation. Cancer Res. 1995 Sep 15; 55(18):4010-3. PMID: 7664273.
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      159. Raz E, Dudler J, Lotz M, Baird SM, Berry CC, Eisenberg RA, Carson D. Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus. 1995 Aug; 4(4):286-92. PMID: 8528225.
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      160. Albani S, Keystone EC, Nelson JL, Ollier WE, La Cava A, Montemayor AC, Weber DA, Montecucco C, Martini A, Carson D. Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Nat Med. 1995 May; 1(5):448-52. PMID: 7585093.
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      161. Huang DF, Siminovitch KA, Liu XY, Olee T, Olsen NJ, Berry C, Carson D, Chen PP. Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. J Clin Invest. 1995 Apr; 95(4):1766-72. PMID: 7706484; PMCID: PMC295700.
      162. Wicks IP, Howell ML, Hancock T, Kohsaka H, Olee T, Carson D. Bacterial lipopolysaccharide copurifies with plasmid DNA: implications for animal models and human gene therapy. Hum Gene Ther. 1995 Mar; 6(3):317-23. PMID: 7779915.
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      163. Carson D, Tan EM. Apoptosis in rheumatic disease. Bull Rheum Dis. 1995 Feb; 44(1):1-3. PMID: 7874249.
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      164. Tighe H, Heaphy P, Baird S, Weigle WO, Carson D. Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice. J Exp Med. 1995 Feb 01; 181(2):599-606. PMID: 7836915; PMCID: PMC2191878.
      165. Herbst RA, Nobori T, Cavenee WK, Carson D, Arden KC. Dinucleotide repeat polymorphism adjacent to CDKN2. Hum Mol Genet. 1994 Dec; 3(12):2265. PMID: 7881438.
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      166. Carson D. The value of epitope mapping in autoimmune diseases. J Clin Invest. 1994 Nov; 94(5):1713. PMID: 7962518; PMCID: PMC294560.
      167. Zhang SY, Klein-Szanto AJ, Sauter ER, Shafarenko M, Mitsunaga S, Nobori T, Carson D, Ridge JA, Goodrow TL. Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res. 1994 Oct 01; 54(19):5050-3. PMID: 7923115.
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      168. Raz E, Carson D, Parker SE, Parr TB, Abai AM, Aichinger G, Gromkowski SH, Singh M, Lew D, Yankauckas MA. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9519-23. PMID: 7937799; PMCID: PMC44844.
      169. Broor S, Kusari AB, Zhang B, Seth P, Richman DD, Carson D, Wachsman W, Lotz M. Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor. J Acquir Immune Defic Syndr. 1994 Jul; 7(7):647-54. PMID: 8207643.
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      170. Deftos M, Olee T, Carson D, Chen PP. Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors. J Clin Invest. 1994 Jun; 93(6):2545-53. PMID: 8200991; PMCID: PMC294479.
      171. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson D. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature. 1994 Apr 21; 368(6473):753-6. PMID: 8152487.
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      172. Albani S, Ravelli A, Massa M, De Benedetti F, Andree G, Roudier J, Martini A, Carson D. Immune responses to the Escherichia coli dnaJ heat shock protein in juvenile rheumatoid arthritis and their correlation with disease activity. J Pediatr. 1994 Apr; 124(4):561-5. PMID: 8151470.
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      173. Taniguchi A, Kohsaka H, Carson D. Competitive RT-PCR ELISA: a rapid, sensitive and non-radioactive method to quantitate cytokine mRNA. J Immunol Methods. 1994 Feb 28; 169(1):101-9. PMID: 7510752.
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      174. Kohsaka H, Carson D. Solid-phase polymerase chain reaction. J Clin Lab Anal. 1994; 8(6):452-5. PMID: 7869187.
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      175. Kobayashi R, Rassenti LZ, Meisenholder G, Carson D, Kipps TJ. Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor. J Immunol. 1993 Dec 15; 151(12):7273-83. PMID: 7505024.
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      176. Cottam HB, Wasson DB, Shih HC, Raychaudhuri A, Di Pasquale G, Carson D. New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation. J Med Chem. 1993 Oct 29; 36(22):3424-30. PMID: 8230132.
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      177. Ribeiro JM, Carson D. Ca2+/Mg(2+)-dependent endonuclease from human spleen: purification, properties, and role in apoptosis. Biochemistry. 1993 Sep 07; 32(35):9129-36. PMID: 8396424.
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      178. Yamanaka H, Hakoda M, Kamatani N, Kashiwazaki S, Carson D. Formation of DNA strand breaks by D-penicillamine and bucillamine in human lymphocytes. Immunopharmacology. 1993 Sep-Oct; 26(2):113-8. PMID: 8282535.
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      179. Watanabe A, Raz E, Kohsaka H, Tighe H, Baird SM, Kipps TJ, Carson D. Induction of antibodies to a kappa V region by gene immunization. J Immunol. 1993 Sep 01; 151(5):2871-6. PMID: 8360497.
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      180. Kohsaka H, Taniguchi A, Chen PP, Ollier WE, Carson D. The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: rapid analysis by anchored polymerase chain reaction and enzyme-linked immunosorbent assay. Eur J Immunol. 1993 Aug; 23(8):1895-901. PMID: 8344352.
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      181. Kohsaka H, Taniguchi A, Richman DD, Carson D. Microtiter format gene quantification by covalent capture of competitive PCR products: application to HIV-1 detection. Nucleic Acids Res. 1993 Jul 25; 21(15):3469-72. PMID: 8346024; PMCID: PMC331446.
      182. Lu EW, Deftos M, Olee T, Huang DF, Soto-Gil RW, Carson D, Chen PP. Generation and molecular analyses of two rheumatoid synovial fluid-derived IgG rheumatoid factors. Arthritis Rheum. 1993 Jul; 36(7):927-37. PMID: 7916590.
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      183. Bishof NA, Welch TR, Beischel LS, Carson D, Donnelly PA. DP polymorphism in HLA-A1,-B8,-DR3 extended haplotypes associated with membranoproliferative glomerulonephritis and systemic lupus erythematosus. Pediatr Nephrol. 1993 Jun; 7(3):243-6. PMID: 8100139.
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      184. Carson D, Ribeiro JM. Apoptosis and disease. Lancet. 1993 May 15; 341(8855):1251-4. PMID: 8098400.
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      185. Kipps TJ, Carson D. Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases. Blood. 1993 May 15; 81(10):2475-87. PMID: 8490163.
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      186. Raz E, Watanabe A, Baird SM, Eisenberg RA, Parr TB, Lotz M, Kipps TJ, Carson D. Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4523-7. PMID: 8506293; PMCID: PMC46544.
      187. Machold KP, Carson D, Lotz M. Transforming growth factor-beta (TGF beta) inhibition of Epstein-Barr virus (EBV)- and interleukin-4 (IL-4)-induced immunoglobulin production in human B lymphocytes. J Clin Immunol. 1993 May; 13(3):219-27. PMID: 8391546.
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      188. Yang PM, Olee T, Carson D, Chen PP. Characterization of two highly homologous autoantibody-related VH1 genes in humans. Scand J Immunol. 1993 Apr; 37(4):504-8. PMID: 8469934.
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      189. Saven A, Kawasaki H, Carrera CJ, Waltz T, Copeland B, Zyroff J, Kosty M, Carson D, Beutler E, Piro LD. 2-Chlorodeoxyadenosine dose escalation in nonhematologic malignancies. J Clin Oncol. 1993 Apr; 11(4):671-8. PMID: 8097527.
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      190. Nobori T, Szinai I, Amox D, Parker B, Olopade OI, Buchhagen DL, Carson D. Methylthioadenosine phosphorylase deficiency in human non-small cell lung cancers. Cancer Res. 1993 Mar 01; 53(5):1098-101. PMID: 8382555.
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      191. Kohsaka H, Chen PP, Taniguchi A, Ollier WE, Carson D. Divergent T cell receptor gamma repertoires in rheumatoid arthritis monozygotic twins. Arthritis Rheum. 1993 Feb; 36(2):213-21. PMID: 8431211.
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      192. Kawasaki H, Carrera CJ, Piro LD, Saven A, Kipps TJ, Carson D. Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine. Blood. 1993 Feb 01; 81(3):597-601. PMID: 8094016.
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      193. Kohsaka H, Chen PP, Taniguchi A, Ollier WE, Carson D. Regulation of the mature human T cell receptor gamma repertoire by biased V-J gene rearrangement. J Clin Invest. 1993 Jan; 91(1):171-8. PMID: 7678601; PMCID: PMC330011.
      194. Saven A, Piro LD, Carrera CJ, Carson D, Beutler E. Hairy cell leukemia: new understanding of biology and treatment. Cancer Treat Res. 1993; 64:15-34. PMID: 7680875.
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      195. Beutler E, Carson D. 2-Chlorodeoxyadenosine: hairy cell leukemia takes a surprising turn. Blood Cells. 1993; 19(3):559-68; discussion 569-72. PMID: 8018939.
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      196. Tighe H, Chen PP, Tucker R, Kipps TJ, Roudier J, Jirik FR, Carson D. Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. J Exp Med. 1993 Jan 01; 177(1):109-18. PMID: 8418195; PMCID: PMC2190869.
      197. Huang DF, Olee T, Masuho Y, Matsumoto Y, Carson D, Chen PP. Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes. J Clin Invest. 1992 Dec; 90(6):2197-208. PMID: 1334971; PMCID: PMC443370.
      198. Kawasaki H, Carrera CJ, Carson D. Quantitative immunoassay of human deoxycytidine kinase in malignant cells. Anal Biochem. 1992 Nov 15; 207(1):193-6. PMID: 1489095.
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      199. Albani S, Carson D, Roudier J. Genetic and environmental factors in the immune pathogenesis of rheumatoid arthritis. Rheum Dis Clin North Am. 1992 Nov; 18(4):729-40. PMID: 1280844.
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      200. Kobayashi R, Picchio G, Kirven M, Meisenholder G, Baird S, Carson D, Mosier DE, Kipps TJ. Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency. Leuk Res. 1992 Oct; 16(10):1013-23. PMID: 1383641.
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      201. Hostetler KY, Richman DD, Carson D, Stuhmiller LM, van Wijk GM, van den Bosch H. Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine. Antimicrob Agents Chemother. 1992 Sep; 36(9):2025-9. PMID: 1416896; PMCID: PMC192430.
      202. Nobori T, Reynolds L, Orvis L, Wu D, Carson D. A polymerase chain reaction-based method for isolation of gene-specific sequences from the interferon-alpha gene cluster. Anal Biochem. 1992 Aug 15; 205(1):42-6. PMID: 1443559.
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      203. Saven A, Carrera CJ, Carson D, Beutler E, Piro LD. 2-Chlorodeoxyadenosine: an active agent in the treatment of cutaneous T-cell lymphoma. Blood. 1992 Aug 01; 80(3):587-92. PMID: 1353380.
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      204. Tzioufas AG, Boumba DS, Skopouli FN, Carson D, Moutsopoulos HM. Inheritance of monoclonal rheumatoid factor cross-reactive idiotypes in primary Sjögren's syndrome (pSS). Comparative studies of a rabbit polyclonal anti-idiotype and 17109 monoclonal anti-idiotype. Eur J Clin Invest. 1992 Jul; 22(7):475-81. PMID: 1516595.
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      205. Carson D. Genetic factors in the etiology and pathogenesis of autoimmunity. FASEB J. 1992 Jul; 6(10):2800-5. PMID: 1634042.
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      206. Kipps TJ, Rassenti LZ, Duffy S, Johnson T, Kobayashi R, Carson D. Immunoglobulin V gene expression in CD5 B-cell malignancies. Ann N Y Acad Sci. 1992 May 04; 651:373-83. PMID: 1376056.
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      207. Martin T, Duffy SF, Carson D, Kipps TJ. Evidence for somatic selection of natural autoantibodies. J Exp Med. 1992 Apr 01; 175(4):983-91. PMID: 1552291; PMCID: PMC2119194.
      208. Carson D, Wasson DB, Esparza LM, Carrera CJ, Kipps TJ, Cottam HB. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2970-4. PMID: 1348362; PMCID: PMC48785.
      209. Soto-Gil RW, Olee T, Klink BK, Kenny TP, Robbins DL, Carson D, Chen PP. A systematic approach to defining the germline gene counterparts of a mutated autoantibody from a patient with rheumatoid arthritis. Arthritis Rheum. 1992 Mar; 35(3):356-63. PMID: 1339266.
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      210. Kay AC, Saven A, Carrera CJ, Carson D, Thurston D, Beutler E, Piro LD. 2-Chlorodeoxyadenosine treatment of low-grade lymphomas. J Clin Oncol. 1992 Mar; 10(3):371-7. PMID: 1346801.
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      211. Olee T, Lu EW, Huang DF, Soto-Gil RW, Deftos M, Kozin F, Carson D, Chen PP. Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. J Exp Med. 1992 Mar 01; 175(3):831-42. PMID: 1740665; PMCID: PMC2119156.
      212. Albani S, Tuckwell JE, Esparza L, Carson D, Roudier J. The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule. J Clin Invest. 1992 Jan; 89(1):327-31. PMID: 1370300; PMCID: PMC442852.
      213. Lu EW, Deftos M, Tighe H, Carson D, Chen PP. Generation and characterization of two monoclonal self-associating IgG rheumatoid factors from a rheumatoid synovium. Arthritis Rheum. 1992 Jan; 35(1):101-5. PMID: 1731807.
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      214. Terai C, Wasson DB, Carrera CJ, Carson D. Dependence of cell survival on DNA repair in human mononuclear phagocytes. J Immunol. 1991 Dec 15; 147(12):4302-6. PMID: 1753100.
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      215. Roudier J, Albani S, Carson D. Immune response to peptides from the third hypervariable region of the beta chain of MHC class II molecules. Implications for the immune response to foreign antigens. Semin Cancer Biol. 1991 Oct; 2(5):283-5. PMID: 1663408.
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      216. Yang PM, Crowley JJ, McDaniel DO, Koopman WJ, Kozin F, Carson D, Chen PP. Genetic studies of four highly homologous rheumatoid factor-associated Vk genes in rheumatoid arthritis patients and normal individuals. Mol Immunol. 1991 Oct; 28(10):1073-83. PMID: 1681428.
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      217. Pratt LF, Szubin R, Carson D, Kipps TJ. Molecular characterization of a supratypic cross-reactive idiotype associated with IgM autoantibodies. J Immunol. 1991 Sep 15; 147(6):2041-6. PMID: 1890310.
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      218. Roudier J, Sette A, Lamont A, Albani S, Karras JG, Carson D. Tolerance to a self peptide from the third hypervariable region of the Es beta chain. Implications for molecular mimicry models of autoimmune disease. Eur J Immunol. 1991 Sep; 21(9):2063-7. PMID: 1889457.
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      219. Rassenti LZ, Pratt LF, Chen PP, Carson D, Kipps TJ. Autoantibody-encoding kappa L chain genes frequently rearranged in lambda L chain-expressing chronic lymphocytic leukemia. J Immunol. 1991 Aug 01; 147(3):1060-6. PMID: 1907304.
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      220. Nobori T, Hexdall LE, Carson D. A polymorphic region defined by pCN2 (the 3' nontranslated region of N-ras) maps to chromosome 9cen-p12. Hum Genet. 1991 Aug; 87(4):433-7. PMID: 1879830.
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      221. Olee T, Yang PM, Siminovitch KA, Olsen NJ, Hillson J, Wu J, Kozin F, Carson D, Chen PP. Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. J Clin Invest. 1991 Jul; 88(1):193-203. PMID: 1676037; PMCID: PMC296020.
      222. Hostetler KY, Carson D, Richman DD. Phosphatidylazidothymidine. Mechanism of antiretroviral action in CEM cells. J Biol Chem. 1991 Jun 25; 266(18):11714-7. PMID: 1711037.
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      223. Nobori T, Karras JG, Della Ragione F, Waltz TA, Chen PP, Carson D. Absence of methylthioadenosine phosphorylase in human gliomas. Cancer Res. 1991 Jun 15; 51(12):3193-7. PMID: 1904005.
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      224. Terai C, Kornbluth RS, Pauza CD, Richman DD, Carson D. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J Clin Invest. 1991 May; 87(5):1710-5. PMID: 2022741; PMCID: PMC295273.
      225. Axelrod O, Silverman GJ, Dev V, Kyle R, Carson D, Kipps TJ. Idiotypic cross-reactivity of immunoglobulins expressed in Waldenström's macroglobulinemia, chronic lymphocytic leukemia, and mantle zone lymphocytes of secondary B-cell follicles. Blood. 1991 Apr 01; 77(7):1484-90. PMID: 1901234.
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      226. Kekow J, Gross WL, Carson D, Lotz M. [Modulation of immunocompetent cells in the synovial fluid TGF-beta]. Immun Infekt. 1991 Apr; 19(2):60-1. PMID: 1677345.
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      227. Terai C, Carson D. Pyrimidine nucleotide and nucleic acid synthesis in human monocytes and macrophages. Exp Cell Res. 1991 Apr; 193(2):375-81. PMID: 1706277.
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      228. Kekow J, Wachsman W, McCutchan JA, Gross WL, Zachariah M, Carson D, Lotz M. Transforming growth factor-beta and suppression of humoral immune responses in HIV infection. J Clin Invest. 1991 Mar; 87(3):1010-6. PMID: 1999481; PMCID: PMC329894.
      229. Carson D, Chen PP, Kipps TJ. New roles for rheumatoid factor. J Clin Invest. 1991 Feb; 87(2):379-83. PMID: 1991824; PMCID: PMC295087.
      230. Carson D, Carrera CJ, Wasson DB, Iizasa T. Deoxyadenosine-resistant human T lymphoblasts with elevated 5'-nucleotidase activity. Biochim Biophys Acta. 1991 Jan 10; 1091(1):22-8. PMID: 1995064.
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      231. Carson D, Chen PP, Silverman GJ, Kipps TJ. Immunoglobulin gene expression in systemic rheumatic diseases. Br J Rheumatol. 1991; 30 Suppl 1:43-6. PMID: 1991239.
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      232. Carrera CJ, Piro LD, Saven A, Beutler E, Terai C, Carson D. 2-Chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes. Adv Exp Med Biol. 1991; 309A:15-8. PMID: 1686349.
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      233. Carson D. The specificity of anti-DNA antibodies in systemic lupus erythematosus. J Immunol. 1991 Jan 01; 146(1):1-2. PMID: 1984440.
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      234. Wu DJ, Reynolds L, Carson D, Nobori T. Molecular genetic analysis of chromosome 9p in methylthioadenosine phosphorylase deficient glioma cell lines. Adv Exp Med Biol. 1991; 309B:207-11. PMID: 1781369.
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      235. Beutler E, Piro LD, Saven A, Kay AC, McMillan R, Longmire R, Carrera CJ, Morin P, Carson D. 2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside. Leuk Lymphoma. 1991; 5(1):1-8. PMID: 27463204.
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      236. Saven A, Carrera CJ, Carson D, Beutler E, Piro LD. 2-Chlorodeoxyadenosine Treatment of Refractory Chronic Lymphocytic Leukemia. Leuk Lymphoma. 1991; 5 Suppl 1:133-8. PMID: 27463495.
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      237. Kipps TJ, Rassenti LZ, Duffy S, Kobayashi R, Martin T, Chen PP, Carson D. Immunoglobulin Gene Rearrangement and Expression in B-CLL. Leuk Lymphoma. 1991; 5 Suppl 1:39-45. PMID: 27463478.
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      238. Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson D, Lotz M. Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8321-5. PMID: 1700428; PMCID: PMC54947.
      239. Carrera CJ, Terai C, Lotz M, Curd JG, Piro LD, Beutler E, Carson D. Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy. J Clin Invest. 1990 Nov; 86(5):1480-8. PMID: 1700795; PMCID: PMC296893.
      240. Kouri T, Crowley J, Aho K, Palosuo T, Isomäki H, von Essen R, Heliövaara M, Carson D, Vaughan JH. Occurrence of two germline-related rheumatoid factor idiotypes in rheumatoid arthritis and in non-rheumatoid seropositive individuals. Clin Exp Immunol. 1990 Nov; 82(2):250-6. PMID: 2122932; PMCID: PMC1535133.
      241. Yang PM, Olsen NJ, Siminovitch KA, Olee T, Kozin F, Carson D, Chen PP. Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases. Proc Natl Acad Sci U S A. 1990 Oct; 87(20):7907-11. PMID: 2122448; PMCID: PMC54860.
      242. Silverman GJ, Schrohenloher RE, Accavitti MA, Koopman WJ, Carson D. Structural characterization of the second major cross-reactive idiotype group of human rheumatoid factors. Association with the VH4 gene family. Arthritis Rheum. 1990 Sep; 33(9):1347-60. PMID: 2403399.
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      243. Carson D, Carrera CJ. Immunodeficiency secondary to adenosine deaminase deficiency and purine nucleoside phosphorylation deficiency. Semin Hematol. 1990 Jul; 27(3):260-9. PMID: 2115692.
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      244. Natvig JB, Randen I, Thompson K, Førre O, Mageed RA, Jefferis R, Carson D, Tighe H, Pascual V, Victor KD. Probing of the rheumatoid factor (RF) V gene repertoire in rheumatoid arthritis (RA) by hybridoma clones. Clin Exp Rheumatol. 1990 Jul-Aug; 8 Suppl 5:75-80. PMID: 2123137.
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      245. Chen PP, Soto-Gil RW, Carson D. The early expression of some human autoantibody-associated heavy chain variable region genes is controlled by specific regulatory elements. Scand J Immunol. 1990 Jun; 31(6):673-8. PMID: 2113307.
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      246. Lotz M, Kekow J, Carson D. Transforming growth factor-beta and cellular immune responses in synovial fluids. J Immunol. 1990 Jun 01; 144(11):4189-94. PMID: 2187926.
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      247. Koopman WJ, Schrohenloher RE, Carson D. Dissociation of expression of two rheumatoid factor cross-reactive kappa L chain idiotopes in rheumatoid arthritis. J Immunol. 1990 May 01; 144(9):3468-72. PMID: 1691758.
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      248. Piro LD, Carrera CJ, Carson D, Beutler E. Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. N Engl J Med. 1990 Apr 19; 322(16):1117-21. PMID: 1969613.
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      249. Thompson KM, Randen I, Natvig JB, Mageed RA, Jefferis R, Carson D, Tighe H, Forre O. Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: incidence of cross-reactive idiotopes and expression of VH and V kappa subgroups. Eur J Immunol. 1990 Apr; 20(4):863-8. PMID: 1693338.
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      250. Kipps TJ, Robbins BA, Tefferi A, Meisenholder G, Banks PM, Carson D. CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies. Am J Pathol. 1990 Apr; 136(4):809-16. PMID: 1691593; PMCID: PMC1877648.
      251. Roudier J, Silverman GJ, Chen PP, Carson D, Kipps TJ. Intraclonal diversity in the VH genes expressed by CD5- chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor. J Immunol. 1990 Feb 15; 144(4):1526-30. PMID: 1689356.
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      252. Silverman GJ, Carson D. Structural characterization of human monoclonal cold agglutinins: evidence for a distinct primary sequence-defined VH4 idiotype. Eur J Immunol. 1990 Feb; 20(2):351-6. PMID: 2107084.
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      253. Guerne PA, Carson D, Lotz M. IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. J Immunol. 1990 Jan 15; 144(2):499-505. PMID: 2104896.
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      254. Crowley JJ, Mageed RA, Silverman GJ, Chen PP, Kozin F, Erger RA, Jefferis R, Carson D. The incidence of a new human cross-reactive idiotype linked to subgroup VHIII heavy chains. Mol Immunol. 1990 Jan; 27(1):87-94. PMID: 2107394.
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      255. Chen PP, Olsen NJ, Yang PM, Soto-Gil RW, Olee T, Siminovitch KA, Carson D. From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all. Int Rev Immunol. 1990; 5(3-4):239-51. PMID: 2130120.
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      256. Chen PP, Silverman GJ, Liu MF, Carson D. Idiotypic and molecular characterization of human rheumatoid factors. Chem Immunol. 1990; 48:63-81. PMID: 2403808.
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      257. Silverman GJ, Chen PP, Carson D. Cold agglutinins: specificity, idiotypy and structural analysis. Chem Immunol. 1990; 48:109-25. PMID: 1688493.
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      258. Kipps TJ, Robbins BA, Carson D. Uniform high frequency expression of autoantibody-associated crossreactive idiotypes in the primary B cell follicles of human fetal spleen. J Exp Med. 1990 Jan 01; 171(1):189-96. PMID: 1688607; PMCID: PMC2187670.
      259. Nelson J, Carson D. Pituitary function studies in a case of mild Hunter's syndrome (MPS IIB). J Med Genet. 1989 Nov; 26(11):731-2. PMID: 2531225; PMCID: PMC1015745.
      260. Nobori T, Yamanaka H, Carson D. Poly(ADP-ribose) polymerase inhibits DNA synthesis initiation in the absence of NAD. Biochem Biophys Res Commun. 1989 Sep 15; 163(2):1113-8. PMID: 2506850.
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      261. Nobori T, Hexdall LE, Carson D. cDNA sequence of human ribosomal protein L31. Nucleic Acids Res. 1989 Sep 12; 17(17):7105. PMID: 2780320; PMCID: PMC318439.
      262. Carson D, Chen PP, Kipps TJ, Roudier J, Silverman GJ, Tighe H. Regulation of rheumatoid factor synthesis. Clin Exp Rheumatol. 1989 Sep-Oct; 7 Suppl 3:S69-73. PMID: 2691162.
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      263. Chen PP, Siminovitch KA, Olsen NJ, Erger RA, Carson D. A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genes. J Clin Invest. 1989 Aug; 84(2):706-10. PMID: 2569476; PMCID: PMC548935.
      264. Kipps TJ, Tomhave E, Pratt LF, Duffy S, Chen PP, Carson D. Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5913-7. PMID: 2503826; PMCID: PMC297741.
      265. Roudier J, Petersen J, Rhodes GH, Luka J, Carson D. Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):5104-8. PMID: 2472638; PMCID: PMC297565.
      266. Goñi FR, Chen PP, McGinnis D, Arjonilla ML, Fernandez J, Carson D, Solomon A, Mendez E, Frangione B. Structural and idiotypic characterization of the L chains of human IgM autoantibodies with different specificities. J Immunol. 1989 May 01; 142(9):3158-63. PMID: 2496160.
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      267. Guerne PA, Zuraw BL, Vaughan JH, Carson D, Lotz M. Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest. 1989 Feb; 83(2):585-92. PMID: 2464001; PMCID: PMC303718.
      268. Liu MF, Robbins DL, Crowley JJ, Sinha S, Kozin F, Kipps TJ, Carson D, Chen PP. Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains. J Immunol. 1989 Jan 15; 142(2):688-94. PMID: 2492051.
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      269. Mosier DE, Gulizia RJ, Baird SM, Spector S, Spector D, Kipps TJ, Fox RI, Carson D, Cooper N, Richman DD. Studies of HIV infection and the development of Epstein-Barr virus-related B cell lymphomas following transfer of human lymphocytes to mice with severe combined immunodeficiency. Curr Top Microbiol Immunol. 1989; 152:195-9. PMID: 2553338.
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      270. Carrera CJ, Yamanaka H, Piro LD, Lotz M, Carson D. Profound toxicity of deoxyadenosine and 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. Adv Exp Med Biol. 1989; 253B:219-25. PMID: 2575348.
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      271. Carson D, Piro LD, Wasson DB, Carrera CJ, Beutler E. Activity of 2-chloro-2'-deoxyadenosine in chronic lymphocytic leukemia, hairy cell leukemia, and autoimmune hemolytic anemia. Adv Exp Med Biol. 1989; 253A:427-31. PMID: 2576181.
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      272. Yamanaka H, Penning CA, Willis EH, Wasson DB, Carson D. Characterization of poly(ADP-ribose) polymerase with human autoantibodies. Adv Exp Med Biol. 1989; 253B:259-65. PMID: 2514589.
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      273. Carson D, Haertle T, Carrera CJ, Willis EH, Wasson DB, Richman DD. 2-halo-2',3'-dideoxyadenosines: metabolically stable dideoxynucleosides with activity against the human immunodeficiency virus (HIV). Adv Exp Med Biol. 1989; 253B:395-8. PMID: 2610127.
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      274. Podor TJ, Jirik FR, Loskutoff DJ, Carson D, Lotz M. Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6. Ann N Y Acad Sci. 1989; 557:374-85; discussion 386-7. PMID: 2660697.
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      275. Yamanaka H, Willis EH, Carson D. Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase recognize cross-reactive epitopes associated with the catalytic site of the enzyme. J Clin Invest. 1989 Jan; 83(1):180-6. PMID: 2463266; PMCID: PMC303659.
      276. Yamanaka H, Olavi E, Kubota M, Wasson DB, Willis EH, Carson D. Heterogeneity of the toxic mechanisms of methylthioadenosine in methylthioadenosine phosphorylase deficient murine lymphoma cells. Adv Exp Med Biol. 1989; 253B:193-9. PMID: 2514586.
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      277. Wasson DB, Yamanaka H, Carson D. Utilization of 2'-deoxynad for ADP-ribose transfer reactions. Adv Exp Med Biol. 1989; 253B:213-8. PMID: 2514587.
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      278. Chen PP, Liu MF, Glass CA, Sinha S, Kipps TJ, Carson D. Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors. Arthritis Rheum. 1989 Jan; 32(1):72-6. PMID: 2492198.
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      279. Willis EH, Carson D, Shultz LD. Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation. Adv Exp Med Biol. 1989; 253B:209-12. PMID: 2610115.
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      280. Jirik FR, Podor TJ, Hirano T, Kishimoto T, Loskutoff DJ, Carson D, Lotz M. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol. 1989 Jan 01; 142(1):144-7. PMID: 2783321.
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      281. Silverman GJ, Goñi F, Fernandez J, Chen PP, Frangione B, Carson D. Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity. J Exp Med. 1988 Dec 01; 168(6):2361-6. PMID: 3143801; PMCID: PMC2189130.
      282. Chen PP, Liu MF, Sinha S, Carson D. A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation. Arthritis Rheum. 1988 Nov; 31(11):1429-31. PMID: 3263866.
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      283. Carson D, Wasson DB. Synthesis of 2',3'-dideoxynucleosides by enzymatic trans-glycosylation. Biochem Biophys Res Commun. 1988 Sep 15; 155(2):829-34. PMID: 3262341.
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      284. Lotz M, Vaughan JH, Carson D. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science. 1988 Sep 02; 241(4870):1218-21. PMID: 2457950.
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      285. Piro LD, Carrera CJ, Beutler E, Carson D. 2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic lymphocytic leukemia. Blood. 1988 Sep; 72(3):1069-73. PMID: 2901280.
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      286. Mageed RA, Carson D, Jefferis R. Immunogenic and antigenic epitopes of immunoglobulins. XXIII. Idiotypy and molecular specificity of human rheumatoid factors: analysis of cross-reactive idiotype of rheumatoid factor paraproteins from the Wa idiotype group in relation to their IgG subclass specificity. Scand J Immunol. 1988 Aug; 28(2):233-40. PMID: 2457937.
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      287. Kipps TJ, Robbins BA, Kuster P, Carson D. Autoantibody-associated cross-reactive idiotypes expressed at high frequency in chronic lymphocytic leukemia relative to B-cell lymphomas of follicular center cell origin. Blood. 1988 Aug; 72(2):422-8. PMID: 3261179.
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      288. Silverman GJ, Goldfien RD, Chen P, Mageed RA, Jefferis R, Goñi F, Frangione B, Fong S, Carson D. Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans. J Clin Invest. 1988 Aug; 82(2):469-75. PMID: 3136191; PMCID: PMC303536.
      289. Crowley JJ, Goldfien RD, Schrohenloher RE, Spiegelberg HL, Silverman GJ, Mageed RA, Jefferis R, Koopman WJ, Carson D, Fong S. Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins. J Immunol. 1988 May 15; 140(10):3411-8. PMID: 3129494.
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      290. Haertle T, Carrera CJ, Wasson DB, Sowers LC, Richman DD, Carson D. Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2',3'-dideoxyadenosine derivatives. J Biol Chem. 1988 Apr 25; 263(12):5870-5. PMID: 3258602.
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      291. Roudier J, Rhodes G, Petersen J, Vaughan JH, Carson D. The Epstein-Barr virus glycoprotein gp110, a molecular link between HLA DR4, HLA DR1, and rheumatoid arthritis. Scand J Immunol. 1988 Apr; 27(4):367-71. PMID: 2452474.
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      292. Carson D, Haertle T, Wasson DB, Richman DD. Biochemical genetic analysis of 2',3'-dideoxyadenosine metabolism in human T lymphocytes. Biochem Biophys Res Commun. 1988 Mar 15; 151(2):788-93. PMID: 3258154.
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      293. Yamanaka H, Penning CA, Willis EH, Wasson DB, Carson D. Characterization of human poly(ADP-ribose) polymerase with autoantibodies. J Biol Chem. 1988 Mar 15; 263(8):3879-83. PMID: 3126180.
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      294. Kipps TJ, Tomhave E, Chen PP, Carson D. Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy. J Exp Med. 1988 Mar 01; 167(3):840-52. PMID: 3127527; PMCID: PMC2188892.
      295. Lotz M, Jirik F, Kabouridis P, Tsoukas C, Hirano T, Kishimoto T, Carson D. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med. 1988 Mar 01; 167(3):1253-8. PMID: 3127525; PMCID: PMC2188869.
      296. Fong S, Chen PP, Crowley JJ, Silverman GJ, Carson D. Idiotypic characteristics of rheumatoid factors. Scand J Rheumatol Suppl. 1988; 75:58-65. PMID: 3149008.
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      297. Chen PP, Fong S, Goni F, Silverman GJ, Fox RI, Liu MF, Frangione B, Carson D. Cross-reacting idiotypes on cryoprecipitating rheumatoid factor. Springer Semin Immunopathol. 1988; 10(1):35-55. PMID: 3137675.
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      298. Fong S, Chen PP, Crowley JJ, Silverman GJ, Carson D. Idiotypes and the structural diversity of human rheumatoid factors. Springer Semin Immunopathol. 1988; 10(2-3):189-201. PMID: 3142069.
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      299. Carson D, Nobori T, Kajander EO, Carrera CJ, Kubota M, Yamanaka H. Methylthioadenosine (MeSAdo) phosphorylase deficiency in malignancy. Adv Exp Med Biol. 1988; 250:179-85. PMID: 3151225.
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      300. Carson D, Carrera CJ, Wasson DB, Yamanaka H. Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes. Adv Enzyme Regul. 1988; 27:395-404. PMID: 2907967.
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      301. Fong S, Chen PP, Fox RI, Goldfien RD, Radoux V, Silverman GJ, Crowley JJ, Roudier J, Carson D. The diversity and idiotypic patterns of human rheumatoid factors in disease. Concepts Immunopathol. 1988; 5:168-91. PMID: 3286006.
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      302. Mageed RA, Carson D, Jefferis R. Analysis of rheumatoid factor autoantibodies in patients with essential mixed cryoglobulinaemia and rheumatoid arthritis. Scand J Rheumatol Suppl. 1988; 75:172-8. PMID: 2467350.
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      303. Chen PP, Fong S, Carson D. Rheumatoid factor. Rheum Dis Clin North Am. 1987 Dec; 13(3):545-68. PMID: 3324205.
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      304. Carson D, Chen PP, Kipps TJ, Radoux V, Jirik FR, Goldfien RD, Fox RI, Silverman GJ, Fong S. Idiotypic and genetic studies of human rheumatoid factors. Arthritis Rheum. 1987 Dec; 30(12):1321-5. PMID: 3124859.
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      305. Chen PP, Robbins DL, Jirik FR, Kipps TJ, Carson D. Isolation and characterization of a light chain variable region gene for human rheumatoid factors. J Exp Med. 1987 Dec 01; 166(6):1900-5. PMID: 3119763; PMCID: PMC2188786.
      306. Richman DD, Kornbluth RS, Carson D. Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. J Exp Med. 1987 Oct 01; 166(4):1144-9. PMID: 2821152; PMCID: PMC2188703.
      307. Yamanaka H, Willis EH, Penning CA, Peebles CL, Tan EM, Carson D. Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase. J Clin Invest. 1987 Sep; 80(3):900-4. PMID: 2442198; PMCID: PMC442319.
      308. Chen PP, Albrandt K, Kipps TJ, Radoux V, Liu FT, Carson D. Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity. J Immunol. 1987 Sep 01; 139(5):1727-33. PMID: 3114376.
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      309. Chen PP, Fong S, Carson D. The use of defined peptides in characterizing idiotypes. Int Rev Immunol. 1987 Jul; 2(4):419-32. PMID: 3153458.
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      310. Silverman GJ, Carson D, Patrick K, Vaughan JH, Fong S. Expression of a germline human kappa chain-associated cross-reactive idiotype after in vitro and in vivo infection with Epstein-Barr virus. Clin Immunol Immunopathol. 1987 Jun; 43(3):403-11. PMID: 3034457.
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      311. Tsoukas CD, Landgraf B, Bentin J, Lamberti JF, Carson D, Vaughan JH. Structural and functional characteristics of the CD3 (T3) molecular complex on human thymocytes. J Immunol. 1987 Jun 01; 138(11):3885-90. PMID: 3108378.
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      312. Willis EH, Carson D, Shultz LD. Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation. Biochem Biophys Res Commun. 1987 May 29; 145(1):581-5. PMID: 3297058.
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      313. Kipps TJ, Fong S, Tomhave E, Chen PP, Goldfien RD, Carson D. High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 1987 May; 84(9):2916-20. PMID: 3106980; PMCID: PMC304771.
      314. Yamanaka H, Kubota M, Carson D. Synergistic inhibition of polyamine synthesis and growth by difluoromethylornithine plus methylthioadenosine in methylthioadenosine phosphorylase-deficient murine lymphoma cells. Cancer Res. 1987 Apr 01; 47(7):1771-4. PMID: 3102048.
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      315. Rhodes G, Rumpold H, Kurki P, Patrick KM, Carson D, Vaughan JH. Autoantibodies in infectious mononucleosis have specificity for the glycine-alanine repeating region of the Epstein-Barr virus nuclear antigen. J Exp Med. 1987 Apr 01; 165(4):1026-40. PMID: 2435830; PMCID: PMC2188573.
      316. Carson D, Seto S, Wasson DB. Pyridine nucleotide cycling and poly(ADP-ribose) synthesis in resting human lymphocytes. J Immunol. 1987 Mar 15; 138(6):1904-7. PMID: 2950173.
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      317. Lotz M, Carson D, Vaughan JH. Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science. 1987 Feb 20; 235(4791):893-5. PMID: 2433770.
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      318. Goldfien RD, Chen PJ, Kipps TJ, Starkebaum G, Heitzmann JG, Radoux V, Fong S, Carson D. Genetic analysis of human B cell hybridomas expressing a cross-reactive idiotype. J Immunol. 1987 Feb 01; 138(3):940-4. PMID: 2433336.
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      319. Lotz M, Tsoukas CD, Curd JG, Carson D, Vaughan JH. Effects of recombinant human interferons on rheumatoid arthritis B lymphocytes activated by Epstein-Barr virus. J Rheumatol. 1987 Feb; 14(1):42-5. PMID: 3033238.
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      320. Rumpold H, Rhodes GH, Bloch PL, Carson D, Vaughan JH. The glycine-alanine repeating region is the major epitope of the Epstein-Barr nuclear antigen-1 (EBNA-1). J Immunol. 1987 Jan 15; 138(2):593-9. PMID: 2432130.
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      321. Carson D, Chen PP, Fox RI, Kipps TJ, Jirik F, Goldfien RD, Silverman G, Radoux V, Fong S. Rheumatoid factor and immune networks. Annu Rev Immunol. 1987; 5:109-26. PMID: 2439101.
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      322. Carson D, Chen PP, Kipps TJ, Radoux V, Jirik F, Goldfien RD, Fox RI, Silverman GJ, Fong S. Molecular basis for the cross-reactive idiotypes on human anti-IgG autoantibodies (rheumatoid factors). Ciba Found Symp. 1987; 129:123-34. PMID: 3315499.
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      323. Chen PP, Fong S, Goni F, Houghten RA, Frangione B, Liu FT, Carson D. Analyses of human rheumatoid factors with anti-idiotypes induced by synthetic peptides. Monogr Allergy. 1987; 22:12-23. PMID: 3325831.
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      324. Silverman GJ, Carson D, Solomon A, Fong S. Human kappa light chain subgroup analysis with synthetic peptide-induced antisera. J Immunol Methods. 1986 Dec 24; 95(2):249-57. PMID: 3098855.
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      325. Radoux V, Chen PP, Sorge JA, Carson D. A conserved human germline V kappa gene directly encodes rheumatoid factor light chains. J Exp Med. 1986 Dec 01; 164(6):2119-24. PMID: 3023521; PMCID: PMC2188481.
      326. Chen PP, Albrandt K, Orida NK, Radoux V, Chen EY, Schrantz R, Liu FT, Carson D. Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8318-22. PMID: 3095834; PMCID: PMC386919.
      327. Montgomery JA, Shortnacy AT, Carson D, Secrist JA. 9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)guanine: a metabolically stable cytotoxic analogue of 2'-deoxyguanosine. J Med Chem. 1986 Nov; 29(11):2389-92. PMID: 3783596.
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      328. Iizasa T, Carson D. Synthesis and release of deoxycytidine by human B and T lymphoblasts. Biochim Biophys Acta. 1986 Sep 19; 888(2):249-51. PMID: 3488764.
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      329. Yamanaka H, Kajander EO, Carson D. Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells. Biochim Biophys Acta. 1986 Sep 19; 888(2):157-62. PMID: 3091083.
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      330. Lotz M, Tsoukas CD, Robinson CA, Dinarello CA, Carson D, Vaughan JH. Basis for defective responses of rheumatoid arthritis synovial fluid lymphocytes to anti-CD3 (T3) antibodies. J Clin Invest. 1986 Sep; 78(3):713-21. PMID: 3091636; PMCID: PMC423658.
      331. Bentin J, Carson D, Vaughan JH, Tsoukas CD. Inhibition of anti-CD3 (T3) antibody-induced activation of T cells by cyclosporine. Transplantation. 1986 Sep; 42(3):317-20. PMID: 3092413.
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      332. Shlomchik MJ, Nemazee DA, Sato VL, Van Snick J, Carson D, Weigert MG. Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells. J Exp Med. 1986 Aug 01; 164(2):407-27. PMID: 3088205; PMCID: PMC2188225.
      333. Fong S, Chen PP, Gilbertson TA, Weber JR, Fox RI, Carson D. Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults. J Immunol. 1986 Jul 01; 137(1):122-8. PMID: 3086444.
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      334. Fong S, Gilbertson TA, Chen PP, Karras JG, Vaughan JH, Carson D. The common occurrence of internal image type anti-idiotypic antibodies in rabbits immunized with monoclonal and polyclonal human IgM rheumatoid factors. Clin Exp Immunol. 1986 Jun; 64(3):570-80. PMID: 3491697; PMCID: PMC1542431.
      335. Kajander EO, Kubota M, Carrera CJ, Montgomery JA, Carson D. Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged S-adenosylmethionine pools. Cancer Res. 1986 Jun; 46(6):2866-70. PMID: 3698011.
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      336. Carson D, Seto S, Wasson DB, Carrera CJ. DNA strand breaks, NAD metabolism, and programmed cell death. Exp Cell Res. 1986 Jun; 164(2):273-81. PMID: 2940104.
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      337. Lotz M, Tsoukas CD, Fong S, Dinarello CA, Carson D, Vaughan JH. Release of lymphokines after Epstein Barr virus infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans. J Immunol. 1986 May 15; 136(10):3636-42. PMID: 3009608.
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      338. Lotz M, Tsoukas CD, Fong S, Dinarello CA, Carson D, Vaughan JH. Release of lymphokines after infection with Epstein Barr virus in vitro. II. A monocyte-dependent inhibitor of interleukin 1 downregulates the production of interleukin 2 and interferon-gamma in rheumatoid arthritis. J Immunol. 1986 May 15; 136(10):3643-8. PMID: 3009609.
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      339. Seto S, Carrera CJ, Wasson DB, Carson D. Inhibition of DNA repair by deoxyadenosine in resting human lymphocytes. J Immunol. 1986 Apr 15; 136(8):2839-43. PMID: 2870121.
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      340. Jirik FR, Sorge J, Fong S, Heitzmann JG, Curd JG, Chen PP, Goldfien R, Carson D. Cloning and sequence determination of a human rheumatoid factor light-chain gene. Proc Natl Acad Sci U S A. 1986 Apr; 83(7):2195-9. PMID: 3083417; PMCID: PMC323258.
      341. Newkirk M, Chen PP, Carson D, Posnett D, Capra JD. Amino acid sequence of a light chain variable region of a human rheumatoid factor of the Wa idiotypic group, in part predicted by its reactivity with antipeptide antibodies. Mol Immunol. 1986 Mar; 23(3):239-44. PMID: 3086710.
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      342. Carson D, Seto S, Wasson DB. Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency. J Exp Med. 1986 Mar 01; 163(3):746-51. PMID: 3950545; PMCID: PMC2188042.
      343. Kajander EO, Kubota M, Willis EH, Carson D. S-adenosylmethionine metabolism as a target for adenosine toxicity. Adv Exp Med Biol. 1986; 195 Pt B:221-6. PMID: 3490121.
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      344. Carrera CJ, Willis EH, Chilcote RR, Kubota M, Carson D. 5'-deoxy-5'-methylthioadenosine phosphorylase deficiency in leukemia: genetics and biochemical aspects. Adv Exp Med Biol. 1986; 195 Pt B:643-50. PMID: 3094332.
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      345. Fox RI, Carson D, Chen P, Fong S. Characterization of a crossreactive idiotype in Sjögren's syndrome. Scand J Rheumatol Suppl. 1986; 61:83-8. PMID: 3109022.
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      346. Fong S, Chen PP, Fox RI, Goldfien RD, Silverman GJ, Radoux V, Jirik F, Vaughan JH, Carson D. Rheumatoid factors in human autoimmune disease: their origin, development and function. Pathol Immunopathol Res. 1986; 5(3-5):305-16. PMID: 3110754.
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      347. Carson D, Carrera CJ, Kubota M, Wasson DB, Iizasa T. Genetic analysis of deoxyadenosine toxicity in dividing human lymphoblasts. Adv Exp Med Biol. 1986; 195 Pt B:207-11. PMID: 3020905.
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      348. Dahbo Y, Carson D, Eriksson S. Increased level of ribonucleotide reductase in deoxyadenosine resistant adenosine deaminase deficient human histiocytic lymphoma cells. Adv Exp Med Biol. 1986; 195 Pt B:231-4. PMID: 3532701.
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      349. Fox RI, Chen P, Carson D, Fong S. Expression of a cross-reactive idiotype on rheumatoid factor in patients with Sjogren's syndrome. J Immunol. 1986 Jan; 136(2):477-83. PMID: 3079786.
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      350. Valentine M, Lotz M, Dinarello CA, Carson D, Vaughan JH. Lymphoblastoid B cell lines produce an interleukin-1-like activity that can be serologically distinct from macrophage interleukin-1. Lymphokine Res. 1986; 5(3):173-83. PMID: 3018386.
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      351. Lotz M, Tsoukas CD, Hench PK, Carson D, Vaughan JH. Release of lymphokines following Epstein-Barr virus infection in vitro of blood lymphocytes from patients with autoimmune diseases. Trans Assoc Am Physicians. 1986; 99:114-24. PMID: 2440173.
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      352. Seto S, Carrera CJ, Wasson DB, Carson D. Biochemical basis for deoxyadenosine and 2-chlorodeoxyadenosine toxicity to resting human lymphocytes. Adv Exp Med Biol. 1986; 195 Pt B:577-82. PMID: 2876594.
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      353. Carson D, Freimark BD. Human lymphocyte hybridomas and monoclonal antibodies. Adv Immunol. 1986; 38:275-311. PMID: 3008522.
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      354. Goñi F, Chen PP, Pons-Estel B, Carson D, Frangione B. Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgM kappa with anti-gamma-globulin activity. J Immunol. 1985 Dec; 135(6):4073-9. PMID: 2415598.
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      355. Fong S, Gilbertson TA, Hueniken RJ, Singhal SK, Vaughan JH, Carson D. IgM rheumatoid factor autoantibody and immunoglobulin-producing precursor cells in the bone marrow of humans. Cell Immunol. 1985 Oct 01; 95(1):157-72. PMID: 2992814.
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      356. Valentine MA, Tsoukas CD, Vaughan JH, Carson D. Characterization of Epstein-Barr virus-specific T-cell hybridomas derived from infectious mononucleosis. Clin Immunol Immunopathol. 1985 Oct; 37(1):56-62. PMID: 2992857.
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      357. Fong S, Chen PP, Gilbertson TA, Fox RI, Vaughan JH, Carson D. Structural similarities in the kappa light chains of human rheumatoid factor paraproteins and serum immunoglobulins bearing a cross-reactive idiotype. J Immunol. 1985 Sep; 135(3):1955-60. PMID: 3926892.
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      358. Tsoukas CD, Landgraf B, Bentin J, Valentine M, Lotz M, Vaughan JH, Carson D. Activation of resting T lymphocytes by anti-CD3 (T3) antibodies in the absence of monocytes. J Immunol. 1985 Sep; 135(3):1719-23. PMID: 3926881.
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      359. Goldfien RD, Chen PP, Fong S, Carson D. Synthetic peptides corresponding to third hypervariable region of human monoclonal IgM rheumatoid factor heavy chains define an immunodominant idiotype. J Exp Med. 1985 Aug 01; 162(2):756-61. PMID: 3926939; PMCID: PMC2187750.
      360. Kubota M, Kajander EO, Carson D. Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts. Cancer Res. 1985 Aug; 45(8):3567-72. PMID: 3926303.
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      361. Valentine MA, Tsoukas CD, Rhodes G, Vaughan JH, Carson D. Phytohemagglutinin binds to the 20-kDa molecule of the T3 complex. Eur J Immunol. 1985 Aug; 15(8):851-4. PMID: 3161747.
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      362. Chen PP, Gõni F, Houghten RA, Fong S, Goldfien R, Vaughan JH, Frangione B, Carson D. Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides. J Exp Med. 1985 Aug 01; 162(2):487-500. PMID: 2410527; PMCID: PMC2187757.
      363. Lotz M, Tsoukas CD, Fong S, Carson D, Vaughan JH. Regulation of Epstein-Barr virus infection by recombinant interferons. Selected sensitivity to interferon-gamma. Eur J Immunol. 1985 May; 15(5):520-5. PMID: 2581792.
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      364. Chen PP, Goñi F, Fong S, Jirik F, Vaughan JH, Frangione B, Carson D. The majority of human monoclonal IgM rheumatoid factors express a "primary structure-dependent" cross-reactive idiotype. J Immunol. 1985 May; 134(5):3281-5. PMID: 3920316.
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      365. Chen PP, Kabat EA, Wu TT, Fong S, Carson D. Possible involvement of human D minigenes in the first complementarity-determining region of kappa light chains. Proc Natl Acad Sci U S A. 1985 Apr; 82(7):2125-7. PMID: 3920660; PMCID: PMC397505.
      366. Iizasa T, Carson D. Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells. Biochim Biophys Acta. 1985 Mar 21; 844(3):280-7. PMID: 3918584.
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      367. Chen PP, Fong S, Houghten RA, Carson D. Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF. J Exp Med. 1985 Feb 01; 161(2):323-31. PMID: 3919139; PMCID: PMC2187561.
      368. Seto S, Carrera CJ, Kubota M, Wasson DB, Carson D. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J Clin Invest. 1985 Feb; 75(2):377-83. PMID: 2579098; PMCID: PMC423498.
      369. Fong S, Chen PP, Vaughan JH, Carson D. Origin and age-associated changes in the expression of a physiologic autoantibody. Gerontology. 1985; 31(4):236-50. PMID: 3876969.
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      370. Carson D, Iizasa T, Seto S, Carrera CJ, Kubota M, Willis EH, Wasson DB, Kajander O. Metabolic basis for immune dysfunction in adenosine deaminase deficiency. Ann N Y Acad Sci. 1985; 451:34-41. PMID: 3878120.
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      371. Rhodes G, Carson D, Valbracht J, Houghten R, Vaughan JH. Human immune responses to synthetic peptides from the Epstein-Barr nuclear antigen. J Immunol. 1985 Jan; 134(1):211-6. PMID: 2981091.
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      372. Tsoukas CD, Valentine M, Lotz M, Vaughan JH, Carson D. The role of the T3 molecular complex on human T lymphocyte-mediated cytotoxicity. Adv Exp Med Biol. 1985; 184:365-85. PMID: 2931002.
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      373. Vaughan JH, Fox RI, Abresch RJ, Tsoukas CD, Curd JG, Carson D. Thoracic duct drainage in rheumatoid arthritis. Clin Exp Immunol. 1984 Dec; 58(3):645-53. PMID: 6334581; PMCID: PMC1577091.
      374. Tsoukas CD, Lambris J, Lotz M, Valentine MA, Vaughan JH, Carson D. Lymphocyte mitogenesis induced by monoclonal antibodies to the T3 complex. Differential modulation by human IgG. Cell Immunol. 1984 Nov; 89(1):66-74. PMID: 6207944.
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      375. Rhodes G, Houghten R, Taulane JP, Carson D, Vaughan J. The immune response to Epstein-Barr nuclear antigen: conformational and structural features of antibody binding to synthetic peptides. Mol Immunol. 1984 Nov; 21(11):1047-54. PMID: 6096700.
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      376. Tsoukas CD, Valentine M, Lotz M, Vaughan JH, Carson D. The role of the T3 molecular complex in antigen recognition and subsequent activation events. Immunol Today. 1984 Nov; 5(11):311-3. PMID: 25290752.
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      377. Iizasa T, Kubota M, Carson D. Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells. Biochem Biophys Res Commun. 1984 Jun 15; 121(2):514-20. PMID: 6428410.
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      378. Kubota M, Carrera CJ, Wasson DB, Carson D. Deoxynucleoside overproduction in deoxyadenosine-resistant, adenosine deaminase-deficient human histiocytic lymphoma cells. Biochim Biophys Acta. 1984 May 22; 804(1):37-43. PMID: 6372866.
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      379. Chen PP, Fong S, Normansell D, Houghten RA, Karras JG, Vaughan JH, Carson D. Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide. J Exp Med. 1984 May 01; 159(5):1502-11. PMID: 6201589; PMCID: PMC2187296.
      380. Carrera CJ, Eddy RL, Shows TB, Carson D. Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization. Proc Natl Acad Sci U S A. 1984 May; 81(9):2665-8. PMID: 6425836; PMCID: PMC345130.
      381. Lakow ES, Valentine MA, Vaughan JH, Tsoukas CD, Carson D. Effects of monoclonal antibodies against lymphocyte surface antigens on interleukin 2 excretion by Epstein-Barr virus-specific human T-cell hybridomas. Cell Immunol. 1984 Apr 15; 85(1):67-74. PMID: 6325024.
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      382. Carson D, Wasson DB, Beutler E. Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):2232-6. PMID: 6585795; PMCID: PMC345472.
      383. Carson D. Increase in the complement-fixing ability of murine IgG anti-lymphocyte antibodies by addition of monoclonal IgM rheumatoid factors. J Immunol Methods. 1984 Mar 30; 68(1-2):103-8. PMID: 6707475.
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      384. Chen PP, Houghten RA, Fong S, Rhodes GH, Gilbertson TA, Vaughan JH, Lerner RA, Carson D. Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes. Proc Natl Acad Sci U S A. 1984 Mar; 81(6):1784-8. PMID: 6200884; PMCID: PMC345005.
      385. Fong S, Gilbertson TA, Chen PP, Vaughan JH, Carson D. Modulation of human rheumatoid factor-specific lymphocyte responses with a cross-reactive anti-idiotype bearing the internal image of antigen. J Immunol. 1984 Mar; 132(3):1183-9. PMID: 6607281.
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      386. Iizasa T, Carson D. Changes in deoxyadenosine production during human lymphocyte mitogenesis. Exp Cell Res. 1984 Mar; 151(1):264-7. PMID: 6607841.
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      387. Carson D, Wasson DB, Lakow E, Kamatani N. Biochemical basis for lymphocyte dysfunction in adenosine deaminase and purine nucleoside phosphorylase deficiencies. Adv Exp Med Biol. 1984; 165 Pt B:133-9. PMID: 6426261.
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      388. Kamatani N, Kubota M, Willis EH, Carson D. 5'-Methylthioadenosine phosphorylase deficiency in malignant cells: recessive expression of the defective phenotype in intraspecies (mouse X mouse) hybrids. Adv Exp Med Biol. 1984; 165 Pt B:279-83. PMID: 6426266.
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      389. Kamatani N, Kubota M, Willis EH, Frincke LA, Carson D. 5'-Methylthioadenosine is the major source of adenine in human cells. Adv Exp Med Biol. 1984; 165 Pt B:83-8. PMID: 6426269.
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      390. Carson D, Wasson DB, Yu A. Cell cycle independent lymphocytotoxicity of 2-chlorodeoxyadenosine. Adv Exp Med Biol. 1984; 165 Pt B:351-6. PMID: 6144251.
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      391. Billings PB, Hoch SO, White PJ, Carson D, Vaughan JH. Antibodies to the Epstein-Barr virus nuclear antigen and to rheumatoid arthritis nuclear antigen identify the same polypeptide. Proc Natl Acad Sci U S A. 1983 Dec; 80(23):7104-8. PMID: 6316343; PMCID: PMC390001.
      392. Spruce WE, McMillan R, Miller W, Fox R, Carson D, Schwartz DB, Hartman GA, Renshaw LW, Beutler E. Transplantation of T-lymphocyte-depleted bone marrow between HLA-mismatched individuals. Transplantation. 1983 Oct; 36(4):369-72. PMID: 6353702.
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      393. Carson D, Fong S. A common idiotope on human rheumatoid factors identified by a hybridoma antibody. Mol Immunol. 1983 Oct; 20(10):1081-7. PMID: 6201726.
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      394. Carson D, Wasson DB, Taetle R, Yu A. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. Blood. 1983 Oct; 62(4):737-43. PMID: 6136305.
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      395. Iizasa T, Kubota M, Carson D. Differential production of deoxyadenosine by human T and B lymphoblasts. J Immunol. 1983 Oct; 131(4):1776-9. PMID: 6352803.
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      396. Fong S, Gilbertson TA, Carson D. The internal image of IgG in cross-reactive anti-idiotypic antibodies against human rheumatoid factors. J Immunol. 1983 Aug; 131(2):719-24. PMID: 6863929.
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      397. Beutler E, Carson D, Dannawi H, Forman L, Kuhl W, West C, Westwood B. Metabolic compensation for profound erythrocyte adenylate kinase deficiency. A hereditary enzyme defect without hemolytic anemia. J Clin Invest. 1983 Aug; 72(2):648-55. PMID: 6308059; PMCID: PMC1129224.
      398. Kubota M, Kamatani N, Carson D. Biochemical genetic analysis of the role of methylthioadenosine phosphorylase in a murine lymphoid cell line. J Biol Chem. 1983 Jun 25; 258(12):7288-91. PMID: 6408072.
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      399. Kubota M, Kamatani N, Daddona PE, Carson D. Characterization of an adenosine deaminase-deficient human histiocytic lymphoma cell line (DHL-9) and selection of mutants deficient in adenosir kinase and deoxycytidine kinase. Cancer Res. 1983 Jun; 43(6):2606-10. PMID: 6303563.
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      400. Carson D, Willis EH, Kamatani N. Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells. Biochem Biophys Res Commun. 1983 Apr 29; 112(2):391-7. PMID: 6601949.
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      401. Kamatani N, Willis EH, Carson D. Selection and characterization of a murine lymphoid cell line partially deficient in S-adenosylhomocysteine hydrolase. Biochim Biophys Acta. 1983 Apr 05; 762(2):205-14. PMID: 6600937.
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      402. Welch MJ, Fong S, Vaughan J, Carson D. Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid. Clin Exp Immunol. 1983 Feb; 51(2):299-304. PMID: 6601551; PMCID: PMC1536905.
      403. Fong S, Vaughan JH, Carson D. Two different rheumatoid factor-producing cell populations distinguished by the mouse erythrocyte receptor and responsiveness to polyclonal B cell activators. J Immunol. 1983 Jan; 130(1):162-4. PMID: 6292300.
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      404. Lakow E, Tsoukas CD, Vaughan JH, Altman A, Carson D. Human T cell hybridomas specific for Epstein Barr virus-infected B lymphocytes. J Immunol. 1983 Jan; 130(1):169-72. PMID: 6292301.
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      405. Slovin SF, Kuberski TT, Carson D, Catalano MA, Reitz EM, Vaughan JH. Antibodies to Epstein-Barr virus associated antigens in Pima Indians with and without rheumatoid arthritis. Rheumatol Int. 1983; 3(2):65-8. PMID: 6312543.
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      406. Kamatani N, Yu AL, Carson D. Deficiency of methylthioadenosine phosphorylase in human leukemic cells in vivo. Blood. 1982 Dec; 60(6):1387-91. PMID: 6814551.
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      407. Fong S, Vaughan JH, Tsoukas CD, Carson D. Selective induction of autoantibody secretion in human bone marrow by Epstein Barr virus. J Immunol. 1982 Nov; 129(5):1941-5. PMID: 6288800.
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      408. Carson D, Wasson DB. Characterization of an adenosine 5'-triphosphate- and deoxyadenosine 5'-triphosphate-activated nucleotidase from human malignant lymphocytes. Cancer Res. 1982 Nov; 42(11):4321-4. PMID: 6290030.
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      409. Tsoukas CD, Carson D, Fong S, Vaughan JH. Molecular interactions in human T cell-mediated cytotoxicity to EBV II. Monoclonal antibody OKT3 inhibits a post-killer-target recognition/adhesion step. J Immunol. 1982 Oct; 129(4):1421-5. PMID: 6286765.
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      410. Pasquali JL, Carson D. [Rheumatoid factors]. Pathol Biol (Paris). 1982 Oct; 30(8):719-26. PMID: 6185910.
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      411. Fong S, Miller JJ, Moore TL, Tsoukas CD, Vaughan JH, Carson D. Frequencies of Epstein-Barr virus-inducible IgM anti-IgG B lymphocytes in normal children and children with juvenile rheumatoid arthritis. Arthritis Rheum. 1982 Aug; 25(8):959-65. PMID: 6288055.
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      412. Tsoukas CD, Carson D, Fong S, Slovin SF, Fox RI, Vaughan JH. Lysis of autologous Epstein-Barr virus-infected B cells by cytotoxic T lymphocytes of rheumatoid arthritis patients. Clin Immunol Immunopathol. 1982 Jul; 24(1):8-14. PMID: 6179673.
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      413. Hershfield MS, Fetter JE, Small WC, Bagnara AS, Williams SR, Ullman B, Martin DW, Wasson DB, Carson D. Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells. J Biol Chem. 1982 Jun 10; 257(11):6380-6. PMID: 6281270.
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      414. Carson D, Wasson DB, Lakow E, Kamatani N. Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase. Proc Natl Acad Sci U S A. 1982 Jun; 79(12):3848-52. PMID: 6808516; PMCID: PMC346525.
      415. McGarrity GJ, Carson D. Adenosine phosphorylase-mediated nucleoside toxicity. Application towards the detection of mycoplasmal infection in mammalian cell cultures. Exp Cell Res. 1982 May; 139(1):199-205. PMID: 6806107.
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      416. Tsoukas CD, Fox RI, Carson D, Fong S, Vaughan JH. Molecular interactions in human T-cell-mediated cytotoxicity to Epstein-Barr virus. I. Blocking of effector cell function by monoclonal antibody OKT3. Cell Immunol. 1982 May 01; 69(1):113-21. PMID: 6286147.
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      417. Slovin SF, Frisman DM, Tsoukas CD, Royston I, Baird SM, Wormsley SB, Carson D, Vaughan JH. Membrane antigen on Epstein--Barr virus-infected human B cells recognized by a monoclonal antibody. Proc Natl Acad Sci U S A. 1982 Apr; 79(8):2649-53. PMID: 6283539; PMCID: PMC346258.
      418. Kamatani N, Willis EH, Carson D. Sequential metabolism of 5'-isobutylthioadenosine by methylthioadenosine phosphorylase and purine-nucleoside phosphorylase in viable human cells. Biochem Biophys Res Commun. 1982 Feb 26; 104(4):1335-42. PMID: 6803802.
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      419. Sabharwal UK, Vaughan JH, Fong S, Bennett PH, Carson D, Curd JG. Activation of the classical pathway of complement by rheumatoid factors. Assessment by radioimmunoassay for C4. Arthritis Rheum. 1982 Feb; 25(2):161-7. PMID: 7066047.
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      420. Kamatani N, Carson D. Differential cyst(e)ine requirements in human T and B lymphoblastoid cell lines. Int Arch Allergy Appl Immunol. 1982; 68(1):84-9. PMID: 6281197.
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      421. Carson D, Lakow E, Wasson DB, Kamatani N. Lymphocyte dysfunction caused by deficiencies in purine metabolism. Immunol Today. 1981 Dec; 2(12):234-8. PMID: 25290650.
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      422. Pasquali JL, Fong S, Tsoukas CD, Slovin SF, Vaughan JH, Carson D. Different populations of rheumatoid factor idiotypes induced by two polyclonal B cell activators, pokeweed mitogen and Epstein--Barr virus. Clin Immunol Immunopathol. 1981 Nov; 21(2):184-9. PMID: 6271428.
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      423. Carson D, Chang KP. Selective killing of Leishmania infected mouse macrophages by 6-methylpurine 2'-deoxyriboside. Life Sci. 1981 Oct 19; 29(16):1617-21. PMID: 7311709.
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      424. Slovin SF, Glassy MC, Dambaugh T, Catalano MA, Curry RA, Ferrone S, Kieff E, Vaughan JH, Carson D. Discordant expression of 2 Epstein-Barr virus-associated antigens, EBNA and RANA, in man-rodent somatic cell hybrids. J Immunol. 1981 Aug; 127(2):585-90. PMID: 6265553.
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      425. Kamatani N, Carson D. Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts. Biochim Biophys Acta. 1981 Jul 17; 675(3-4):344-50. PMID: 6791702.
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      426. Pasquali JL, Fong S, Tsoukas CD, Hench PK, Vaughan JH, Carson D. Selective lymphocyte deficiency in seronegative rheumatoid arthritis. Arthritis Rheum. 1981 Jun; 24(6):770-3. PMID: 6972764.
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      427. Tsoukas CD, Fox RI, Slovin SF, Carson D, Pellegrino M, Fong S, Pasquali JL, Ferrone S, Kung P, Vaughan JH. T lymphocyte-mediated cytotoxicity against autologous EBV-genome-bearing B cells. J Immunol. 1981 May; 126(5):1742-6. PMID: 6163816.
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      428. Fong S, Tsoukas CD, Frincke LA, Lawrance SK, Holbrook TL, Vaughan JH, Carson D. Age-associated changes in Epstein-Barr virus-induced human lymphocyte autoantibody responses. J Immunol. 1981 Mar; 126(3):910-4. PMID: 6257787.
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      429. Fong S, Pasquali JL, Tsoukas CD, Vaughan JH, Carson D. Age-related restriction of the light chain heterogeneity of anti-IgG antibodies induced by Epstein-Barr virus stimulation of human lymphocytes in vitro. Clin Immunol Immunopathol. 1981 Mar; 18(3):344-50. PMID: 6265130.
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      430. Kamatani N, Nelson-Rees WA, Carson D. Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme. Proc Natl Acad Sci U S A. 1981 Feb; 78(2):1219-23. PMID: 6785752; PMCID: PMC319979.
      431. Fong S, Tsoukas CD, Pasquali JL, Fox RI, Rose JE, Raiklen D, Carson D, Vaughan JH. Fractionation of human lymphocyte subpopulations on immunoglobulin coated Petri dishes. J Immunol Methods. 1981; 44(2):171-82. PMID: 6456310.
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      432. Carson D, Pasquali JL, Tsoukas CD, Fong S, Slovin SF, Lawrance SK, Slaughter L, Vaughan JH. Physiology and pathology of rheumatoid factors. Springer Semin Immunopathol. 1981; 4(2):161-79. PMID: 7323953.
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      433. Carson D, Kaye J, Wasson DB. The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts. J Immunol. 1981 Jan; 126(1):348-52. PMID: 6256438.
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      434. Fong S, Fox RI, Rose JE, Liu J, Tsoukas CD, Carson D, Vaughan JH. Solid-phase selection of human T lymphocyte subpopulations using monoclonal antibodies. J Immunol Methods. 1981; 46(2):153-63. PMID: 7031131.
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      435. Carson D, Wasson DB, Kaye J, Ullman B, Martin DW, Robins RK, Montgomery JA. Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. Proc Natl Acad Sci U S A. 1980 Nov; 77(11):6865-9. PMID: 6256765; PMCID: PMC350391.
      436. Kamatani N, Carson D. Abnormal regulation of methylthioadenosine and polyamine metabolism in methylthioadenosine phosphorylase-deficient human leukemic cell lines. Cancer Res. 1980 Nov; 40(11):4178-82. PMID: 6781742.
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      437. Pasquali JL, Fong S, Tsoukas C, Vaughan JH, Carson D. Inheritance of immunoglobulin M rheumatoid-factor idiotypes. J Clin Invest. 1980 Oct; 66(4):863-6. PMID: 7419724; PMCID: PMC371664.
      438. Catalano MA, Carson D, Stastny P, Freer S, Vaughan JH. Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw4. Arthritis Rheum. 1980 Sep; 23(9):1049-52. PMID: 6251856.
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      439. Tsoukas CD, Carson D, Fong S, Pasquali JL, Vaughan JH. Cellular requirements for pokeweed mitogen-induced autoantibody production rheumatoid arthritis. J Immunol. 1980 Sep; 125(3):1125-9. PMID: 6967890.
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      440. Howell SB, Chu B, Mendelsohn J, Carson D, Kung FH, Seegmiller JE. Thymidine as a chemotherapeutic agent: pharmacologic, cytokinetic, and biochemical studies in a patient with T-cell acute lymphocytic leukemia. J Natl Cancer Inst. 1980 Aug; 65(2):277-84. PMID: 6967527.
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      441. Kaplan RA, Curd JG, Deheer DH, Carson D, Pangburn MK, Müller-Eberhard HJ, Vaughan JH. Metabolism of C4 and factor B in rheumatoid arthritis. Relation to rheumatoid factor. Arthritis Rheum. 1980 Aug; 23(8):911-20. PMID: 6967727.
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      442. Slovin SF, Vaughan JH, Carson D. Changes in the expression of two Epstein-Barr virus-associated antigens, EBNA and RANA, during the cell cycle of transformed human B lymphoblasts. Int J Cancer. 1980 Jul 15; 26(1):9-12. PMID: 6263806.
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      443. Catalano MA, Carson D, Niederman JC, Feorino P, Vaughan JH. Antibody to the rheumatoid arthritis nuclear antigen. Its relationship to in vivo Epstein-Barr virus infection. J Clin Invest. 1980 May; 65(5):1238-42. PMID: 6245108; PMCID: PMC371458.
      444. Theofilopoulos AN, Carson D, Tavassoli M, Slovin SF, Speers WC, Jensen FB, Vaughan JH. Evidence for the presence of receptors for C3 and IgG Fc on human synovial cells. Arthritis Rheum. 1980 Jan; 23(1):1-9. PMID: 7352929.
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      445. Carson D, Kaye J, Wasson DB. Differences in deoxyadenosine metabolism in human and mouse lymphocytes. J Immunol. 1980 Jan; 124(1):8-12. PMID: 6965300.
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      446. Daneo-Moore L, Bourbeau P, Weinstein R, Carson D. Effects of cerulenin on antibiotic-induced lysis of streptococcus faecalis (S. faecium). Antimicrob Agents Chemother. 1979 Dec; 16(6):858-61. PMID: 119485; PMCID: PMC352966.
      447. Catalano MA, Carson D, Slovin SF, Richman DD, Vaughan JH. Antibodies to Epstein-Barr virus-determined antigens in normal subjects and in patients with seropositive rheumatoid arthritis. Proc Natl Acad Sci U S A. 1979 Nov; 76(11):5825-8. PMID: 230491; PMCID: PMC411744.
      448. Carson D, Kaye J, Matsumoto S, Seegmiller JE, Thompson L. Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines. Proc Natl Acad Sci U S A. 1979 May; 76(5):2430-3. PMID: 313056; PMCID: PMC383615.
      449. Dunne JV, Carson D, Spiegelberg HL, Alspaugh MA, Vaughan JH. IgA rheumatoid factor in the sera and saliva of patients with rheumatoid arthritis and Sjögren's syndrome. Ann Rheum Dis. 1979 Apr; 38(2):161-5. PMID: 443882; PMCID: PMC1000343.
      450. Carson D, Kaye J, Seegmiller JE. Metabolism and toxicity of 9-beta-D-arabinofuranosyladenine in human malignant T cells and B cells in tissue culture. Adv Exp Med Biol. 1979; 122B:299-307. PMID: 317567.
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      451. Carson D, Kaye J, Matsumoto S, Seegmiller JE, Thompson L. Uniqueness of deoxyribonucleotide metabolism in human malignant T cell lines. Adv Exp Med Biol. 1979; 122B:381-8. PMID: 317570.
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      452. Slaughter L, Carson D, Jensen FC, Holbrook TL, Vaughan JH. In vitro effects of Epstein-Barr virus on peripheral blood mononuclear cells from patients with rheumatoid arthritis and normal subjects. J Exp Med. 1978 Nov 01; 148(5):1429-34. PMID: 214511; PMCID: PMC2185048.
      453. Carson D, Kaye J, Seegmiller JE. Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine. J Immunol. 1978 Nov; 121(5):1726-31. PMID: 309480.
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      454. Robbins DL, Moore TL, Carson D, Vaughan JH. Relative reactivities of rheumatoid factors in serum and cells. Evidence for a selective deficiency in serum rheumatoid factor. Arthritis Rheum. 1978 Sep-Oct; 21(7):820-6. PMID: 358993.
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      455. Willis RC, Carson D, Seegmiller JE. Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line. Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3042-4. PMID: 210448; PMCID: PMC392709.
      456. Carson D, Lawrance S. Light chain heterogeneity of 19S and 7S anti-gamma-globulins in rheumatoid arthritis and subacute bacterial endocarditis. Arthritis Rheum. 1978 May; 21(4):438-40. PMID: 418786.
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      457. Carson D, Bayer AS, Eisenberg RA, Lawrance S, Theofilopoulos A. IgG rheumatoid factor in subacute bacterial endocarditis: relationship to IgM rheumatoid factor and circulating immune complexes. Clin Exp Immunol. 1978 Jan; 31(1):100-3. PMID: 639341; PMCID: PMC1541191.
      458. Carson D, Kaye J. Deoxyribonucleoside toxicity in adenosine deaminase and purine nucleoside phosphorylase deficiency: implications for the development of new immunosuppressive agents. Ciba Found Symp. 1978; (68):115-33. PMID: 115660.
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      459. Carson D, Kaye J, Seegmiller JE. Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s). Proc Natl Acad Sci U S A. 1977 Dec; 74(12):5677-81. PMID: 202960; PMCID: PMC431856.
      460. Carson D, Lawrance S, Catalano MA, Vaughan JH, Abraham G. Radioimmunoassay of IgG and IgM rheumatoid factors reacting with human IgG. J Immunol. 1977 Jul; 119(1):295-300. PMID: 326961.
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      461. Carson D, Goldblum R, Keightley R, Seegmiller JE. Immunoreactive adenosine deaminase (ADA) in cultured fibroblasts from patients with combined immunodeficiency disease. Adv Exp Med Biol. 1977; 76A:463-70. PMID: 855722.
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      462. Carson D, Goldblum R, Seegmiller JE. Quantitative immunoassay of adenosine deaminase in combined immunodeficiency disease. J Immunol. 1977 Jan; 118(1):270-3. PMID: 830750.
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      463. Carson D, Seegmiller JE. Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis. J Clin Invest. 1976 Feb; 57(2):274-82. PMID: 176177; PMCID: PMC436651.
      464. Carson D, Kulczycki A, Metzger H. Interaction of IgE with rat basophilic leukemia cells. III. Release of intact receptors on cell-free particles. J Immunol. 1975 Jan; 114(1 Pt 1):158-60. PMID: 1112975.
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      465. Carson D, Metzger H. Interaction of IgE with rat basophilic leukemia cells. IV. Antibody-induced redistribution of IgE receptors. J Immunol. 1974 Oct; 113(4):1271-7. PMID: 4606677.
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      466. Aptekar RG, Klippel JH, Becker KE, Carson D, Seaman WE, Decker JL. Avascular necrosis of the talus, scaphoid, and metatarsal head in systemic lupus erythematosus. Clin Orthop Relat Res. 1974 Jun; (101):127-8. PMID: 4837924.
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      467. Weigert M, Raschke WC, Carson D, Cohn M. Immunochemical analysis of the idiotypes of mouse myeloma proteins with specificity for levan or dextran. J Exp Med. 1974 Jan 01; 139(1):137-47. PMID: 4128444; PMCID: PMC2139518.
      468. Palmer WW, Carson D, Sloan LW. THE INFLUENCE OF IODINE ON THE EXCRETION OF CREATINE IN EXOPHTHALMIC GOITER. J Clin Invest. 1929 Feb; 6(4):597-608. PMID: 16693846; PMCID: PMC434769.
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