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Dennis Carson

Title(s)Recall Faculty, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emaildcarson@ucsd.edu
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    Collapse Research 
    Collapse research activities and funding
    Adjuvant Discovery for Vaccines against West Nile Virus and Influenza
    NIH 272201400051C-0-0-1Sep 30, 2014 - Sep 29, 2018
    Role: Principal Investigator
    Small molecule stimulators of innate immune receptors
    NIH/NIAID 272200900034C-0-0-1Sep 30, 2009 - Sep 29, 2014
    Role: Principal Investigator
    MUCOSAL IMMUNOSTIMULANTS FOR BIODEFENSE
    NIH/NIAID R21AI057436Jan 1, 2004 - Dec 31, 2005
    Role: Principal Investigator
    OPTIMIZED SYNTHETIC TLR LIGANDS FOR BIODEFENSE
    NIH/NIAID U01AI056453Jul 15, 2003 - Dec 31, 2007
    Role: Principal Investigator
    Third Biennial Arthritis Research Conference
    NIH/NIAMS R13AR047878Apr 1, 2001 - Mar 31, 2002
    Role: Principal Investigator
    MOLECULAR THERAPEUTICS OF RHEUMATOID ARTHRITIS
    NIH/NIAMS P50AR044850Sep 28, 1998 - Aug 31, 2004
    Role: Principal Investigator
    ETIOPATHOGENESIS OF RA
    NIH/NIAMS P01AR041897Apr 3, 1995 - Mar 3, 1999
    Role: Principal Investigator
    CHROMOSOME 9P ABERRATIONS IN HUMAN GLIOMA
    NIH/NCI U01CA064976Feb 10, 1995 - Nov 30, 1999
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASE CENTER
    NIH P60AR040770Aug 1, 1991 - Feb 28, 2002
    Role: Co-Principal Investigator
    TRAINING IN CLINICAL IMMUNOLOGY
    NIH/NIAMS T32AR007567Jul 1, 1991 - May 31, 2002
    Role: Principal Investigator
    NUCLEOTIDE METABOLISM IN LYMPHOCYTES AND MACROPHAGES
    NIH/NIAID R01AI029151Sep 30, 1989 - Jul 31, 1992
    Role: Principal Investigator
    INTERNATIONAL POSTDOCTORAL RESEARCH IN AIDS
    NIH/FIC T22TW000011Jul 1, 1988 - Jun 30, 1993
    Role: Principal Investigator
    PROTECTION OF T CELLS FROM HTLV-III/LAV INFECTION
    NIH/NIAID R01AI024466Aug 1, 1987 - Jul 31, 1990
    Role: Principal Investigator
    RHEUMATOID FACTOR--GENETICS, PATHOGENESIS AND MODULATION
    NIH/NIAMS R37AR025443Sep 1, 1979 - May 31, 2000
    Role: Principal Investigator
    RHEUMATOID FACTOR: GENETICS, PATHOGENESIS, &MODULATION
    NIH/NIADDK R01AM025443Sep 1, 1979 - Aug 31, 1989
    Role: Principal Investigator
    RHEUMATOID FACTOR: GENETICS, PATHOGENESIS, &MODULATION
    NIH/NIAMS R01AR025443Sep 1, 1979 - Aug 31, 1989
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Principal Investigator
    REGULATION OF SENESCENCE AND APOPTOSIS IN LYMPHOCYTES
    NIH/NIGMS R01GM023200Jun 30, 1976 - Jun 30, 2004
    Role: Principal Investigator
    TRAINING IN MOLECULAR ASPECTS OF CLINICAL IMMUNOLOGY
    NIH/NIAMS T32AR007144Jul 1, 1975 - Jun 30, 1997
    Role: Co-Principal Investigator
    TRAINING IN CLINICAL IMMUNOLOGY
    NIH/NIADDK T32AM007144Jul 1, 1975 - Jun 30, 1990
    Role: Principal Investigator
    DMID CLINICAL RESEARCH OPERATIONS AND MANAGEMENT SUPPORT
    NIH N01AI000000Dec 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A novel calcium influx inducer and a TLR7 agonist are synergistic co-adjuvants that enhance cross-reactive immunity against influenza in young and aged mice. Vaccine. 2026 Feb 27; 74:128189. Yokoyama Y, Yao S, Cozza R, Gil F, Mclaughlin I, Quiroz PA, Brown T, Shukla NM, Chan M, Messer K, Pu M, Corr M, Carson DA, Hayashi T. PMID: 41512501.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. FZD7 expression marks mammary tumor-initiating cells. Proc Natl Acad Sci U S A. 2025 Nov 18; 122(46):e2522465122. Wu CCN, De Luna N, Hairston E, Jeffs ED, Key A, Adams SR, Advani SJ, Gaasterland T, Carson DA, Willert K. PMID: 41218118; PMCID: PMC12646316.
      View in: PubMed   Mentions:
    3. Enhancing vaccine immunogenicity through heterologous prime-boost regimen with multiple nasal boosting with liposomal TLR7 ligand. Vaccine. 2025 Oct 24; 65:127778. Hayashi T, Yao S, Sato-Kaneko F, Cozza R, Baba H, Jin J, Mclaughlin I, Gil F, Quiroz PA, Shukla NM, Chan M, Cottam HB, Carson DA. PMID: 41067087.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy. Commun Med (Lond). 2025 Aug 29; 5(1):378. Niimura M, Sakamoto Y, Shimoda M, Harada N, Maeda A, Wada S, Murata K, Thinyakul C, Liu S, Ohara H, Iwamoto A, Kanamori Y, Nita A, Wakao M, Suda Y, Oshiumi H, Hayashi T, Carson DA, Shinchi H, Moroishi T. PMID: 40883594; PMCID: PMC12397435.
      View in: PubMed   Mentions: 1  
    5. Design and Application of Conjugatable Small Molecule Toll-Like Receptor 4 Ligands. Bioconjug Chem. 2025 Jul 16; 36(7):1409-1420. Mahara Y, Fukuda I, Tanaka R, Oyama SY, Shinchi H, Suda Y, Shukla NM, Chan M, Hayashi T, Cottam HB, Carson DA, Wakao M. PMID: 40533421.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Structure-Activity Relationship Studies in Benzothiadiazoles as Novel Vaccine Adjuvants. J Med Chem. 2024 08 22; 67(16):13703-13722. Belsuzarri MM, Sako Y, Brown TD, Chan M, Cozza R, Jin J, Sato-Kaneko F, Yao S, Pu M, Messer K, Hayashi T, Cottam HB, Corr M, Carson DA, Shukla NM. PMID: 39115891.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx. ACS Chem Biol. 2023 04 21; 18(4):982-993. Sako Y, Sato-Kaneko F, Shukla NM, Yao S, Belsuzarri MM, Chan M, Saito T, Lao FS, Kong H, Puffer M, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T. PMID: 37039433; PMCID: PMC10127211.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    8. Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model. J Immunother Cancer. 2023 01; 11(1). Shankara Narayanan JS, Hayashi T, Erdem S, McArdle S, Tiriac H, Ray P, Pu M, Mikulski Z, Miller A, Messer K, Carson D, Schoenberger S, White RR. PMID: 36634919; PMCID: PMC9843215.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    9. A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination. Vaccines (Basel). 2022 Oct 11; 10(10). Sato-Kaneko F, Yao S, Lao FS, Sako Y, Jin J, Shukla NM, Cottam HB, Chan M, Belsuzarri MM, Carson DA, Hayashi T. PMID: 36298559; PMCID: PMC9611830.
      View in: PubMed   Mentions: 4  
    10. A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity. Front Pharmacol. 2022; 13:869649. Shukla NM, Sato-Kaneko F, Yao S, Pu M, Chan M, Lao FS, Sako Y, Saito T, Messer K, Hayashi T, Cottam HB, Corr M, Carson DA. PMID: 35479316; PMCID: PMC9035538.
      View in: PubMed   Mentions: 4  
    11. Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects. ACS Chem Biol. 2022 04 15; 17(4):957-968. Shinchi H, Komaki F, Yuki M, Ohara H, Hayakawa N, Wakao M, Cottam HB, Hayashi T, Carson DA, Moroishi T, Suda Y. PMID: 35353497.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsPHPublic Health
    12. Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity. ACS Chem Biol. 2022 01 21; 17(1):217-229. Saito T, Shukla NM, Sato-Kaneko F, Sako Y, Hosoya T, Yao S, Lao FS, Messer K, Pu M, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34985883; PMCID: PMC8788586.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models. Mol Cancer Ther. 2022 01; 21(1):113-124. Do M, Wu CCN, Sonavane PR, Juarez EF, Adams SR, Ross J, Rodriguez Y Baena A, Patel C, Mesirov JP, Carson DA, Advani SJ, Willert K. PMID: 34667113; PMCID: PMC8742765.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    14. Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge. Front Immunol. 2021; 12:701445. Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34650551; PMCID: PMC8505803.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Sato-Kaneko F, Yao S, Lao FS, Nan J, Shpigelman J, Cheng A, Saito T, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Molina AJ, Corr M, Hayashi T, Carson DA. PMID: 34078669; PMCID: PMC8201894.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation. Bioorg Med Chem. 2021 08 01; 43:116242. Shukla NM, Chan M, Lao FS, Chu PJ, Belsuzarri M, Yao S, Nan J, Sato-Kaneko F, Saito T, Hayashi T, Corr M, Carson DA, Cottam HB. PMID: 34274759; PMCID: PMC8992012.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release. Front Pharmacol. 2021; 12:668609. Shpigelman J, Lao FS, Yao S, Li C, Saito T, Sato-Kaneko F, Nolan JP, Shukla NM, Pu M, Messer K, Cottam HB, Carson DA, Corr M, Hayashi T. PMID: 33935791; PMCID: PMC8085554.
      View in: PubMed   Mentions: 15  
    18. Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities. ACS Appl Bio Mater. 2021 03 15; 4(3):2732-2741. Shinchi H, Yuki M, Yamauchi T, Niimura M, Wakao M, Cottam HB, Hayashi T, Carson DA, Moroishi T, Suda Y. PMID: 35014312.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    19. Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Wang Q, Kim SY, Matsushita H, Wang Z, Pandyarajan V, Matsuda M, Ohashi K, Tsuchiya T, Roh YS, Kiani C, Zhao Y, Chan M, Devkota S, Lu SC, Hayashi T, Carson DA, Seki E. PMID: 33443222; PMCID: PMC7817133.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    20. Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Front Pharmacol. 2020; 11:607713. Hosoya T, Shukla NM, Fujita Y, Yao S, Lao FS, Baba H, Yasuda S, Cottam HB, Carson DA, Hayashi T, Corr M. PMID: 33390996; PMCID: PMC7773657.
      View in: PubMed   Mentions: 1  
    21. Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells. Elife. 2020 12 17; 9. Gumber D, Do M, Suresh Kumar N, Sonavane PR, Wu CCN, Cruz LS, Grainger S, Carson D, Gaasterland T, Willert K. PMID: 33331818; PMCID: PMC7759383.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    22. A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity. Front Immunol. 2020; 11:1207. Sato-Kaneko F, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Chu PJ, Burkhart D, Schoener R, Matsutani T, Carson DA, Corr M, Hayashi T. PMID: 32636840; PMCID: PMC7318308.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    23. Editorial: Wnt Signaling in Immune Cell Regulation During Microbial Infection and Cancer. Front Immunol. 2020; 11:1133. Blumenthal A, Martin-Orozco E, McBride JW, Carson DA, Sen M. PMID: 32582205; PMCID: PMC7295116.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Immunostimulatory TLR7 agonist-nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Adv Ther (Weinh). 2020 Jun; 3(6). Huang CH, Mendez N, Echeagaray OH, Weeks J, Wang J, Yao S, Blair SL, Gude N, Trogler WC, Carson DA, Hayashi T, Kummel AC. PMID: 33644299; PMCID: PMC7904104.
      View in: PubMed   Mentions: 9  
    25. Synthetic and immunological studies on the OCT4 immunodominant motif antigen-based anti-cancer vaccine. Cancer Biol Med. 2020 02 15; 17(1):132-141. Chen T, Liu K, Xu J, Zhan T, Liu M, Li L, Yang Z, Yuan S, Zou W, Lin G, Carson DA, Wu CCN, Wang X. PMID: 32296581; PMCID: PMC7142840.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands. Bioorg Med Chem Lett. 2020 02 01; 30(3):126840. Baba A, Wakao M, Shinchi H, Chan M, Hayashi T, Yao S, Cottam HB, Carson DA, Suda Y. PMID: 31864800.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    27. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 12; 8(23):e1901105. Battistella C, Callmann CE, Thompson MP, Yao S, Yeldandi AV, Hayashi T, Carson DA, Gianneschi NC. PMID: 31664791.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli. J Med Chem. 2019 11 14; 62(21):9521-9540. Chan M, Lao FS, Chu PJ, Shpigelman J, Yao S, Nan J, Sato-Kaneko F, Li V, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 31603681; PMCID: PMC8992017.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α-Mannose as Adjuvants. Bioconjug Chem. 2019 11 20; 30(11):2811-2821. Shinchi H, Yamaguchi T, Moroishi T, Yuki M, Wakao M, Cottam HB, Hayashi T, Carson DA, Suda Y. PMID: 31560198.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    30. Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model. Cancer Immunol Res. 2019 10; 7(10):1714-1726. Narayanan JSS, Ray P, Hayashi T, Whisenant TC, Vicente D, Carson DA, Miller AM, Schoenberger SP, White RR. PMID: 31409607; PMCID: PMC6774877.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    31. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/T-cell factor complex. Br J Pharmacol. 2019 09; 176(17):3390-3406. Wang Z, Zhou L, Xiong Y, Yu S, Li H, Fan J, Li F, Su Z, Song J, Sun Q, Liu SS, Xia Y, Zhao L, Li S, Guo F, Huang P, Carson DA, Lu D. PMID: 31236922; PMCID: PMC6692576.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    32. Conjugation of a Small-Molecule TLR7 Agonist to Silica Nanoshells Enhances Adjuvant Activity. ACS Appl Mater Interfaces. 2019 Jul 31; 11(30):26637-26647. Huang CH, Mendez N, Echeagaray OH, Weeks J, Wang J, Vallez CN, Gude N, Trogler WC, Carson DA, Hayashi T, Kummel AC. PMID: 31276378.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    33. Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1370-1377. Zhang S, Zhang H, Ghia EM, Huang J, Wu L, Zhang J, Lam S, Lei Y, He J, Cui B, Widhopf GF, Yu J, Schwab R, Messer K, Jiang W, Parker BA, Carson DA, Kipps TJ. PMID: 30622177; PMCID: PMC6347692.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    34. Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators. ACS Med Chem Lett. 2018 Dec 13; 9(12):1156-1159. Shukla NM, Chan M, Hayashi T, Carson DA, Cottam HB. PMID: 30613317; PMCID: PMC6295859.
      View in: PubMed   Mentions: 8  
    35. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. Biomed Res Int. 2018; 2018:8091283. Sato-Kaneko F, Wang X, Yao S, Hosoya T, Lao FS, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Carson DA, Corr M, Hayashi T. PMID: 30406141; PMCID: PMC6199861.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    36. Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):E7522-E7531. Su Z, Song J, Wang Z, Zhou L, Xia Y, Yu S, Sun Q, Liu SS, Zhao L, Li S, Wei L, Carson DA, Lu D. PMID: 30038030; PMCID: PMC6094128.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    37. Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6836-E6844. Hosoya T, Sato-Kaneko F, Ahmadi A, Yao S, Lao F, Kitaura K, Matsutani T, Carson DA, Hayashi T. PMID: 29967183; PMCID: PMC6055176.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    38. Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. SLAS Discov. 2018 10; 23(9):960-973. Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M. PMID: 29751735; PMCID: PMC6697428.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    39. Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands. J Med Chem. 2017 11 22; 60(22):9142-9161. Chan M, Kakitsubata Y, Hayashi T, Ahmadi A, Yao S, Shukla NM, Oyama SY, Baba A, Nguyen B, Corr M, Suda Y, Carson DA, Cottam HB, Wakao M. PMID: 29049886; PMCID: PMC5940354.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    40. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 09 21; 2(18). Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE. PMID: 28931759; PMCID: PMC5621908.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    41. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice. J Virol. 2017 10 01; 91(19). Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M. PMID: 28724768; PMCID: PMC5599744.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    42. Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity. ACS Comb Sci. 2017 08 14; 19(8):533-543. Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 28657707; PMCID: PMC5841913.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    43. Cell-penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury. Nanomedicine. 2017 Aug; 13(6):1925-1932. Griffin JI, Cheng SKK, Hayashi T, Carson D, Saraswathy M, Nair DP, Simberg D. PMID: 28428051; PMCID: PMC5618708.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    44. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL. PMID: 27912060; PMCID: PMC5512418.
      View in: PubMed   Mentions: 243     Fields:    Translation:AnimalsCells
    45. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13150-13155. Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson DA, Lu D. PMID: 27799526; PMCID: PMC5135380.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    46. PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease. JCI Insight. 2016 Sep 22; 1(15):e87958. Bram Z, Louiset E, Ragazzon B, Renouf S, Wils J, Duparc C, Boutelet I, Rizk-Rabin M, Libé R, Young J, Carson D, Vantyghem MC, Szarek E, Martinez A, Stratakis CA, Bertherat J, Lefebvre H. PMID: 27699247; PMCID: PMC5033753.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    47. A window-of-opportunity biomarker study of etodolac in resectable breast cancer. Cancer Med. 2015 Oct; 4(10):1583-8. Schwab RB, Kato S, Crain B, Pu M, Messer K, Weidner N, Blair SL, Wallace AM, Carson DA, Parker BA. PMID: 26275572; PMCID: PMC4618628.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    48. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19; 26(8):1713-23. Shinchi H, Crain B, Yao S, Chan M, Zhang SS, Ahmadiiveli A, Suda Y, Hayashi T, Cottam HB, Carson DA. PMID: 26193334.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    49. Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes. PLoS One. 2015; 10(6):e0129867. Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam HB, Carson DA, Corr M. PMID: 26076454; PMCID: PMC4468074.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    50. Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15 Suppl:S167-9. Choi MY, Widhopf GF, Wu CC, Cui B, Lao F, Sadarangani A, Cavagnaro J, Prussak C, Carson DA, Jamieson C, Kipps TJ. PMID: 26297272; PMCID: PMC4548279.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    51. Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):E3050-7. Barrett CL, DeBoever C, Jepsen K, Saenz CC, Carson DA, Frazer KA. PMID: 26015570; PMCID: PMC4466751.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    52. Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers. PLoS Comput Biol. 2015 Mar; 11(3):e1004105. DeBoever C, Ghia EM, Shepard PJ, Rassenti L, Barrett CL, Jepsen K, Jamieson CH, Carson D, Kipps TJ, Frazer KA. PMID: 25768983; PMCID: PMC4358997.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansCells
    53. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015 Mar; 89(6):3221-35. Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA. PMID: 25568203; PMCID: PMC4337541.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    54. Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17266-71. Zhang S, Cui B, Lai H, Liu G, Ghia EM, Widhopf GF, Zhang Z, Wu CC, Chen L, Wu R, Schwab R, Carson DA, Kipps TJ. PMID: 25411317; PMCID: PMC4260559.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    55. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 25288184; PMCID: PMC4250372.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    56. TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant. J Transl Med. 2014 Aug 14; 12:211. Saenz R, Futalan D, Leutenez L, Eekhout F, Fecteau JF, Sundelius S, Sundqvist S, Larsson M, Hayashi T, Minev B, Carson D, Esener S, Messmer B, Messmer D. PMID: 25123824; PMCID: PMC4261565.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    57. Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments. Genome Biol. 2014 Aug 07; 15(8):420. Smith EN, Jepsen K, Khosroheidari M, Rassenti LZ, D'Antonio M, Ghia EM, Carson DA, Jamieson CH, Kipps TJ, Frazer KA. PMID: 25103687; PMCID: PMC4165357.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    58. An innovative system for 3D clinical photography in the resource-limited settings. J Transl Med. 2014 Jun 15; 12:169. Baghdadchi S, Liu K, Knapp J, Prager G, Graves S, Akrami K, Manuel R, Bastos R, Reid E, Carson D, Esener S, Carson J, Liu YT. PMID: 24929434; PMCID: PMC4065604.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    59. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014 Aug; 350(2):330-40. Hayashi T, Crain B, Yao S, Caneda CD, Cottam HB, Chan M, Corr M, Carson DA. PMID: 24893985; PMCID: PMC4109491.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    60. The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1409-14. Fernandez A, Huggins IJ, Perna L, Brafman D, Lu D, Yao S, Gaasterland T, Carson DA, Willert K. PMID: 24474766; PMCID: PMC3910637.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    61. Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand. J Innate Immun. 2014; 6(3):315-24. Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T. PMID: 24192551; PMCID: PMC3972367.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    62. Whole transcriptome sequencing enables discovery and analysis of viruses in archived primary central nervous system lymphomas. PLoS One. 2013; 8(9):e73956. DeBoever C, Reid EG, Smith EN, Wang X, Dumaop W, Harismendy O, Carson D, Richman D, Masliah E, Frazer KA. PMID: 24023918; PMCID: PMC3762708.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    63. Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. Eur J Dermatol. 2013 Sep-Oct; 23(5):618-28. Crain B, Yao S, Keophilaone V, Promessi V, Kang M, Barberis A, Maj R, Mura E, Passini N, Holldack J, Ochoa R, Cottam HB, Carson DA, Hayashi T. PMID: 24225049; PMCID: PMC3959874.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    64. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 23656327; PMCID: PMC3722616.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    65. Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. PLoS One. 2013; 8(3):e58714. Barrett CL, Schwab RB, Jung H, Crain B, Goff DJ, Jamieson CH, Thistlethwaite PA, Harismendy O, Carson DA, Frazer KA. PMID: 23527012; PMCID: PMC3604164.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    66. Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. PLoS One. 2012; 7(9):e45860. Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam HB, Carson DA, Corr M. PMID: 23029281; PMCID: PMC3461028.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    67. Increased aldehyde dehydrogenase activity in high-risk chronic lymphocytic leukemia. Leuk Lymphoma. 2013 Feb; 54(2):400-2. Wu RP, Li H, Rassenti LZ, Hayashi T, Wu CN, Kipps TJ, Messer K, Carson DA. PMID: 22784365; PMCID: PMC3821178.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    68. Analysis of high-throughput screening assays using cluster enrichment. Stat Med. 2012 Dec 30; 31(30):4175-89. Pu M, Hayashi T, Cottam H, Mulvaney J, Arkin M, Corr M, Carson D, Messer K. PMID: 22763983; PMCID: PMC3635947.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    69. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. PMID: 22768113; PMCID: PMC3387267.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    70. Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1. J Immunol. 2012 Apr 01; 188(7):2977-80. Norton JT, Hayashi T, Crain B, Cho JS, Miller LS, Corr M, Carson DA. PMID: 22387558; PMCID: PMC3311728.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    71. In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma. Leuk Res. 2012 May; 36(5):598-600. Kim Y, Gast SM, Endo T, Lu D, Carson D, Schmidt-Wolf IG. PMID: 22386728.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    72. Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand. Mediators Inflamm. 2012; 2012:262394. Hayashi T, Yao S, Crain B, Chan M, Cottam HB, Lao F, Carson DA, Corr M. PMID: 22619481; PMCID: PMC3348532.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    73. Targeting the Wnt/beta-catenin pathway with the antifungal agent ciclopirox olamine in a murine myeloma model. In Vivo. 2011 Nov-Dec; 25(6):887-93. Kim Y, Schmidt M, Endo T, Lu D, Carson D, Schmidt-Wolf IG. PMID: 22021681.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    74. Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections. J Innate Immun. 2012; 4(2):213-8. Zinkernagel AS, Hruz P, Uchiyama S, von Köckritz-Blickwede M, Schuepbach RA, Hayashi T, Carson DA, Nizet V. PMID: 21860217; PMCID: PMC3388268.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    75. Inhibition of Wnt signaling and cancer stem cells. Oncotarget. 2011 Aug; 2(8):587. Lu D, Carson DA. PMID: 21860066; PMCID: PMC3248212.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    76. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13253-7. Lu D, Choi MY, Yu J, Castro JE, Kipps TJ, Carson DA. PMID: 21788521; PMCID: PMC3156152.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansCells
    77. Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues. Bioorg Med Chem. 2011 Sep 15; 19(18):5648-69. Nicolaou KC, Ellery SP, Rivas F, Saye K, Rogers E, Workinger TJ, Schallenberger M, Tawatao R, Montero A, Hessell A, Romesberg F, Carson D, Burton D. PMID: 21840722; PMCID: PMC3348725.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    78. Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11163-8. Norton JT, Hayashi T, Crain B, Corr M, Carson DA. PMID: 21690387; PMCID: PMC3131380.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    79. Increased in vivo efficacy of lenalidomide and thalidomide by addition of ethacrynic acid. In Vivo. 2011 May-Jun; 25(3):325-33. Schmidt M, Kim Y, Gast SM, Endo T, Lu D, Carson D, Schmidt-Wolf IG. PMID: 21576405.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    80. Synthesis and characterization of PEGylated toll like receptor 7 ligands. Bioconjug Chem. 2011 Mar 16; 22(3):445-54. Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, Tawatao RI, Kalenian K, Zhang Y, Hayashi Y, Lao FS, Cottam HB, Carson DA. PMID: 21338093; PMCID: PMC3063487.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    81. Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2. Melanoma Res. 2011 Feb; 21(1):66-75. Hayashi T, Chan M, Norton JT, Wu CC, Yao S, Cottam HB, Tawatao RI, Corr M, Carson DA, Daniels GA. PMID: 21030882; PMCID: PMC3057341.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    82. Influencing the Wnt signaling pathway in multiple myeloma. Anticancer Res. 2011 Feb; 31(2):725-30. Kim Y, Reifenberger G, Lu D, Endo T, Carson DA, Gast SM, Meschenmoser K, Nowak M, Schmidt-Wolf IG. PMID: 21378363.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    83. Increased in vivo efficacy of lenalidomide by addition of piroctone olamine. In Vivo. 2011 Jan-Feb; 25(1):99-103. Kim Y, Alpmann P, Blaum-Feder S, Krämer S, Endo T, Lu D, Carson D, Schmidt-Wolf IG. PMID: 21282741.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    84. In vivo efficacy of griseofulvin against multiple myeloma. Leuk Res. 2011 Aug; 35(8):1070-3. Kim Y, Alpmann P, Blaum-Feder S, Krämer S, Endo T, Lu D, Carson D, Schmidt-Wolf IG. PMID: 21112630.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    85. Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid. Beilstein J Org Chem. 2010 Sep 01; 6:742-7. Zhang Y, Elliot G, Saldanha A, Tsigelny I, Carson D, Wrasidlo W. PMID: 20978615; PMCID: PMC2956464.
      View in: PubMed   Mentions:
    86. Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7479-84. Wu RP, Hayashi T, Cottam HB, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab RB, Carson DA. PMID: 20368435; PMCID: PMC2867719.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    87. Repression of beta-catenin signaling by PPAR gamma ligands. Eur J Pharmacol. 2010 Jun 25; 636(1-3):198-202. Lu D, Carson DA. PMID: 20303941; PMCID: PMC2866743.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    88. Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. Int J Urol. 2010 May; 17(5):483-90. Hayashi T, Crain B, Corr M, Chan M, Cottam HB, Maj R, Barberis A, Leoni L, Carson DA. PMID: 20337728; PMCID: PMC3876967.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    89. Optimizing PCR assays for DNA-based cancer diagnostics. J Comput Biol. 2010 Mar; 17(3):369-81. Bashir A, Lu Q, Carson D, Raphael BJ, Liu YT, Bafna V. PMID: 20377451; PMCID: PMC3213025.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    90. Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14; 4(12):e8294. Lu D, Liu JX, Endo T, Zhou H, Yao S, Willert K, Schmidt-Wolf IG, Kipps TJ, Carson DA. PMID: 20011538; PMCID: PMC2789382.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    91. Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. BMC Pharmacol. 2009 Nov 30; 9:13. Lu D, Carson DA. PMID: 19948059; PMCID: PMC2789054.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    92. The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. Biomaterials. 2009 Oct; 30(30):6035-40. Yang D, Pornpattananangkul D, Nakatsuji T, Chan M, Carson D, Huang CM, Zhang L. PMID: 19665786; PMCID: PMC2735618.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    93. Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem. 2009 Jun; 20(6):1194-200. Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, Corr M, Wrasidlo W, Cottam HB, Carson DA. PMID: 19445505; PMCID: PMC2976567.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    94. Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2764-9. Hayashi T, Gray CS, Chan M, Tawatao RI, Ronacher L, McGargill MA, Datta SK, Carson DA, Corr M. PMID: 19188597; PMCID: PMC2634806.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    95. Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):606-9. Jin G, Lu D, Yao S, Wu CC, Liu JX, Carson DA, Cottam HB. PMID: 19121941; PMCID: PMC5940355.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    96. Targeting Wnt pathway in lymphoma and myeloma cells. Br J Haematol. 2009 Mar; 144(5):796-8. Schmidt M, Sievers E, Endo T, Lu D, Carson D, Schmidt-Wolf IG. PMID: 19036118.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    97. A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variants. Nucleic Acids Res. 2008 Nov; 36(20):e130. Lu Q, Nunez E, Lin C, Christensen K, Downs T, Carson DA, Wang-Rodriguez J, Liu YT. PMID: 18794177; PMCID: PMC2582611.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    98. In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell Immunol. 2008 Feb; 251(2):78-85. Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M. PMID: 18495099; PMCID: PMC4012540.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    99. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R123-32. Hayashi T, Cottam HB, Chan M, Jin G, Tawatao RI, Crain B, Ronacher L, Messer K, Carson DA, Corr M. PMID: 18480244; PMCID: PMC2494819.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    100. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):3047-52. Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE, Widhopf GF, Rassenti LZ, Cantwell MJ, Prussak CE, Carson DA, Kipps TJ. PMID: 18287027; PMCID: PMC2268582.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimalsCells
    101. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2313-8. Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson DA, Stupack DG. PMID: 18268346; PMCID: PMC2268133.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    102. Opposing roles of RNA receptors TLR3 and RIG-I in the inflammatory response to double-stranded RNA in a Kaposi's sarcoma cell line. Cell Immunol. 2007 Oct; 249(2):55-62. Livengood AJ, Wu CC, Carson DA. PMID: 18155685; PMCID: PMC2262282.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    103. Optimization of primer design for the detection of variable genomic lesions in cancer. Bioinformatics. 2007 Nov 01; 23(21):2807-15. Bashir A, Liu YT, Raphael BJ, Carson D, Bafna V. PMID: 17766270.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    104. A novel approach for determining cancer genomic breakpoints in the presence of normal DNA. PLoS One. 2007 Apr 18; 2(4):e380. Liu YT, Carson DA. PMID: 17440616; PMCID: PMC1847701.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    105. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3990-5. Wu CC, Hayashi T, Takabayashi K, Sabet M, Smee DF, Guiney DD, Cottam HB, Carson DA. PMID: 17360465; PMCID: PMC1820696.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    106. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. Bioorg Med Chem Lett. 2006 Sep 01; 16(17):4559-63. Jin G, Wu CC, Tawatao RI, Chan M, Carson DA, Cottam HB. PMID: 16784848.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    107. Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral Res. 2006 Aug; 71(1):53-63. Barnard DL, Day CW, Bailey K, Heiner M, Montgomery R, Lauridsen L, Winslow S, Hoopes J, Li JK, Lee J, Carson DA, Cottam HB, Sidwell RW. PMID: 16621037; PMCID: PMC7114261.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    108. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1828-33. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. PMID: 16446426; PMCID: PMC1413670.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    109. Guanosine analog in the pyrido[2,3-d]pyrimidine ring system as a potential toll-like receptor agonist. Nucleosides Nucleotides Nucleic Acids. 2006; 25(12):1391-7. Jin G, Wu CC, Carson DA, Cottam HB. PMID: 17067960.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    110. Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18567-71. Lu D, Cottam HB, Corr M, Carson DA. PMID: 16352713; PMCID: PMC1317972.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    111. Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. J Med Chem. 2005 Oct 06; 48(20):6409-22. Barchéchath SD, Tawatao RI, Corr M, Carson DA, Cottam HB. PMID: 16190767.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    112. Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. Bioorg Med Chem Lett. 2005 Apr 01; 15(7):1785-8. Barchéchath SD, Tawatao RI, Corr M, Carson DA, Cottam HB. PMID: 15780606.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    113. The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2525-30. Kolluri SK, Corr M, James SY, Bernasconi M, Lu D, Liu W, Cottam HB, Leoni LM, Carson DA, Zhang XK. PMID: 15699354; PMCID: PMC548323.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    114. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol. 2005 Jan 15; 174(2):864-70. Ohata J, Zvaifler NJ, Nishio M, Boyle DL, Kalled SL, Carson DA, Kipps TJ. PMID: 15634908.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    115. 3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner. J Exp Ther Oncol. 2004 Oct; 4(3):223-37. Diccianni MB, Yu J, Meppelink G, de Vries M, Shao L, Gebauer S, Shih H, Roberts W, Kilcoin NP, Pullen J, Carson DA, Yu AL. PMID: 15724842.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    116. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 2004 Jul; 114(2):270-9. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide DH, Carson DA, Raz E. PMID: 15254594; PMCID: PMC449749.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    117. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9757-62. Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, Ferreira A, Ciesielski C, Carson DA, Corr M. PMID: 15210948; PMCID: PMC470747.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansCells
    118. Necessity of oligonucleotide aggregation for toll-like receptor 9 activation. J Biol Chem. 2004 Aug 06; 279(32):33071-8. Wu CC, Lee J, Raz E, Corr M, Carson DA. PMID: 15184382.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    119. Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma. Cancer Cell. 2004 Jun; 5(6):565-74. Hedvat M, Jain A, Carson DA, Leoni LM, Huang G, Holden S, Lu D, Corr M, Fox W, Agus DB. PMID: 15193259.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    120. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3118-23. Lu D, Zhao Y, Tawatao R, Cottam HB, Sen M, Leoni LM, Kipps TJ, Corr M, Carson DA. PMID: 14973184; PMCID: PMC365753.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
    121. WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum. 2004 Feb; 50(2):488-97. Sen M, Cheng YH, Goldring MB, Lotz MK, Carson DA. PMID: 14872491.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    122. Apoptosis induced by molecular targeting therapy in hematological malignancies. Acta Haematol. 2004; 111(1-2):107-23. Adachi S, Leoni LM, Carson DA, Nakahata T. PMID: 14646349.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    123. Roles of B cells in rheumatoid arthritis. Arthritis Res Ther. 2003; 5 Suppl 4:S1-6. Silverman GJ, Carson DA. PMID: 15180890; PMCID: PMC2833442.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    124. Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells. Hum Gene Ther. 2003 Jun 10; 14(9):849-60. Wu CC, Castro JE, Motta M, Cottam HB, Kyburz D, Kipps TJ, Corr M, Carson DA. PMID: 12828856.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    125. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6646-51. Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB. PMID: 12738885; PMCID: PMC164501.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    126. Hairy-cell leukaemia as a model for drug development. Best Pract Res Clin Haematol. 2003 Mar; 16(1):83-9. Carson DA, Leoni LM. PMID: 12670467.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    127. Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling. Arthritis Rheum. 2003 Mar; 48(3):642-50. Kyburz D, Rethage J, Seibl R, Lauener R, Gay RE, Carson DA, Gay S. PMID: 12632416.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    128. Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum. 2002 Nov; 46(11):2867-77. Sen M, Reifert J, Lauterbach K, Wolf V, Rubin JS, Corr M, Carson DA. PMID: 12428226.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    129. Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene. 2002 Sep 26; 21(43):6598-605. Rhee CS, Sen M, Lu D, Wu C, Leoni L, Rubin J, Corr M, Carson DA. PMID: 12242657.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    130. Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors. Chem Pharm Bull (Tokyo). 2002 Mar; 50(3):364-7. Shih H, Cottam HB, Carson DA. PMID: 11911199.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    131. Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol. 2002 Jan 01; 168(1):51-6. Ronaghy A, Prakken BJ, Takabayashi K, Firestein GS, Boyle D, Zvailfler NJ, Roord ST, Albani S, Carson DA, Raz E. PMID: 11751945.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    132. An infectious origin of extraskeletal calcification. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):7846-7. Carson DA. PMID: 9653101; PMCID: PMC33867.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
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