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Dennis Carson

Title(s)Recall Faculty, Medicine
SchoolHealth Sciences
Phone858-534-5408
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    Collapse Research 
    Collapse Research Activities and Funding
    Adjuvant Discovery for Vaccines against West Nile Virus and Influenza
    NIH 272201400051C-0-0-1Sep 30, 2014 - Sep 29, 2018
    Role: Principal Investigator
    DMID CLINICAL RESEARCH OPERATIONS AND MANAGEMENT SUPPORT
    NIH/NIAID N01AI000000Apr 1, 2012 - Sep 30, 2019
    Role: Principal Investigator
    Small molecule stimulators of innate immune receptors
    NIH/NIAID 272200900034C-0-0-1Sep 30, 2009 - Sep 29, 2014
    Role: Principal Investigator
    MUCOSAL IMMUNOSTIMULANTS FOR BIODEFENSE
    NIH/NIAID R21AI057436Jan 1, 2004 - Dec 31, 2005
    Role: Principal Investigator
    OPTIMIZED SYNTHETIC TLR LIGANDS FOR BIODEFENSE
    NIH/NIAID U01AI056453Jul 15, 2003 - Dec 31, 2007
    Role: Principal Investigator
    Third Biennial Arthritis Research Conference
    NIH/NIAMS R13AR047878Apr 1, 2001 - Mar 31, 2002
    Role: Principal Investigator
    MOLECULAR THERAPEUTICS OF RHEUMATOID ARTHRITIS
    NIH/NIAMS P50AR044850Sep 28, 1998 - Aug 31, 2004
    Role: Principal Investigator
    ETIOPATHOGENESIS OF RA
    NIH/NIAMS P01AR041897Apr 3, 1995 - Mar 3, 1999
    Role: Principal Investigator
    CHROMOSOME 9P ABERRATIONS IN HUMAN GLIOMA
    NIH/NCI U01CA064976Feb 10, 1995 - Nov 30, 1999
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASE CENTER
    NIH/NIAMS P60AR040770Aug 1, 1991 - Mar 6, 1997
    Role: Co-Principal Investigator
    TRAINING IN CLINICAL IMMUNOLOGY
    NIH/NIAMS T32AR007567Jul 1, 1991 - May 31, 2002
    Role: Principal Investigator
    NUCLEOTIDE METABOLISM IN LYMPHOCYTES AND MACROPHAGES
    NIH/NIAID R01AI029151Sep 30, 1989 - Jul 31, 1992
    Role: Principal Investigator
    INTERNATIONAL POSTDOCTORAL RESEARCH IN AIDS
    NIH/FIC T22TW000011Jul 1, 1988 - Jun 30, 1993
    Role: Principal Investigator
    PROTECTION OF T CELLS FROM HTLV-III/LAV INFECTION
    NIH/NIAID R01AI024466Aug 1, 1987 - Jul 31, 1990
    Role: Principal Investigator
    RHEUMATOID FACTOR--GENETICS, PATHOGENESIS AND MODULATION
    NIH/NIAMS R37AR025443Sep 1, 1979 - May 31, 2000
    Role: Principal Investigator
    RHEUMATOID FACTOR: GENETICS, PATHOGENESIS, &MODULATION
    NIH/NIADDK R01AM025443Sep 1, 1979 - Aug 31, 1989
    Role: Principal Investigator
    RHEUMATOID FACTOR: GENETICS, PATHOGENESIS, &MODULATION
    NIH/NIAMS R01AR025443Sep 1, 1979 - Aug 31, 1989
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Apr 1, 1978 - Sep 29, 2012
    Role: Co-Principal Investigator
    REGULATION OF SENESCENCE AND APOPTOSIS IN LYMPHOCYTES
    NIH/NIGMS R01GM023200Jun 30, 1976 - Jun 30, 2004
    Role: Principal Investigator
    TRAINING IN MOLECULAR ASPECTS OF CLINICAL IMMUNOLOGY
    NIH/NIAMS T32AR007144Jul 1, 1975 - Jun 30, 1997
    Role: Co-Principal Investigator
    TRAINING IN CLINICAL IMMUNOLOGY
    NIH/NIADDK T32AM007144Jul 1, 1975 - Jun 30, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baba A, Wakao M, Shinchi H, Chan M, Hayashi T, Yao S, Cottam HB, Carson DA, Suda Y. Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands. Bioorg Med Chem Lett. 2020 Feb 01; 30(3):126840. PMID: 31864800.
      View in: PubMed
    2. Battistella C, Callmann CE, Thompson MP, Yao S, Yeldandi AV, Hayashi T, Carson DA, Gianneschi NC. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 Dec; 8(23):e1901105. PMID: 31664791.
      View in: PubMed
    3. Chan M, Lao FS, Chu PJ, Shpigelman J, Yao S, Nan J, Sato-Kaneko F, Li V, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli. J Med Chem. 2019 Nov 14; 62(21):9521-9540. PMID: 31603681.
      View in: PubMed
    4. Shinchi H, Yamaguchi T, Moroishi T, Yuki M, Wakao M, Cottam HB, Hayashi T, Carson DA, Suda Y. Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and a-Mannose as Adjuvants. Bioconjug Chem. 2019 Nov 20; 30(11):2811-2821. PMID: 31560198.
      View in: PubMed
    5. Narayanan JSS, Ray P, Hayashi T, Whisenant TC, Vicente D, Carson DA, Miller AM, Schoenberger SP, White RR. Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model. Cancer Immunol Res. 2019 Oct; 7(10):1714-1726. PMID: 31409607.
      View in: PubMed
    6. Wang Z, Zhou L, Xiong Y, Yu S, Li H, Fan J, Li F, Su Z, Song J, Sun Q, Liu SS, Xia Y, Zhao L, Li S, Guo F, Huang P, Carson DA, Lu D. Salinomycin exerts anti-colorectal cancer activity by targeting the ß-catenin/T-cell factor complex. Br J Pharmacol. 2019 Sep; 176(17):3390-3406. PMID: 31236922.
      View in: PubMed
    7. Huang CH, Mendez N, Echeagaray OH, Weeks J, Wang J, Vallez CN, Gude N, Trogler WC, Carson DA, Hayashi T, Kummel AC. Conjugation of a Small-Molecule TLR7 Agonist to Silica Nanoshells Enhances Adjuvant Activity. ACS Appl Mater Interfaces. 2019 Jul 31; 11(30):26637-26647. PMID: 31276378.
      View in: PubMed
    8. Zhang S, Zhang H, Ghia EM, Huang J, Wu L, Zhang J, Lam S, Lei Y, He J, Cui B, Widhopf GF, Yu J, Schwab R, Messer K, Jiang W, Parker BA, Carson DA, Kipps TJ. Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1370-1377. PMID: 30622177.
      View in: PubMed
    9. Shukla NM, Chan M, Hayashi T, Carson DA, Cottam HB. Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators. ACS Med Chem Lett. 2018 Dec 13; 9(12):1156-1159. PMID: 30613317.
      View in: PubMed
    10. Sato-Kaneko F, Wang X, Yao S, Hosoya T, Lao FS, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Carson DA, Corr M, Hayashi T. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. Biomed Res Int. 2018; 2018:8091283. PMID: 30406141.
      View in: PubMed
    11. Su Z, Song J, Wang Z, Zhou L, Xia Y, Yu S, Sun Q, Liu SS, Zhao L, Li S, Wei L, Carson DA, Lu D. Tumor promoter TPA activates Wnt/ß-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):E7522-E7531. PMID: 30038030.
      View in: PubMed
    12. Hosoya T, Sato-Kaneko F, Ahmadi A, Yao S, Lao F, Kitaura K, Matsutani T, Carson DA, Hayashi T. Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6836-E6844. PMID: 29967183.
      View in: PubMed
    13. Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M. Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. SLAS Discov. 2018 10; 23(9):960-973. PMID: 29751735.
      View in: PubMed
    14. Chan M, Kakitsubata Y, Hayashi T, Ahmadi A, Yao S, Shukla NM, Oyama SY, Baba A, Nguyen B, Corr M, Suda Y, Carson DA, Cottam HB, Wakao M. Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands. J Med Chem. 2017 11 22; 60(22):9142-9161. PMID: 29049886.
      View in: PubMed
    15. Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 09 21; 2(18). PMID: 28931759.
      View in: PubMed
    16. Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice. J Virol. 2017 10 01; 91(19). PMID: 28724768.
      View in: PubMed
    17. Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-?B Activation without Intrinsic Activity. ACS Comb Sci. 2017 08 14; 19(8):533-543. PMID: 28657707.
      View in: PubMed
    18. Griffin JI, Cheng SKK, Hayashi T, Carson D, Saraswathy M, Nair DP, Simberg D. Cell-penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury. Nanomedicine. 2017 Aug; 13(6):1925-1932. PMID: 28428051.
      View in: PubMed
    19. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. PMID: 27912060.
      View in: PubMed
    20. Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson DA, Lu D. Prodigiosin inhibits Wnt/ß-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13150-13155. PMID: 27799526.
      View in: PubMed
    21. Bram Z, Louiset E, Ragazzon B, Renouf S, Wils J, Duparc C, Boutelet I, Rizk-Rabin M, Libé R, Young J, Carson D, Vantyghem MC, Szarek E, Martinez A, Stratakis CA, Bertherat J, Lefebvre H. PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease. JCI Insight. 2016 Sep 22; 1(15):e87958. PMID: 27699247.
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    22. Schwab RB, Kato S, Crain B, Pu M, Messer K, Weidner N, Blair SL, Wallace AM, Carson DA, Parker BA. A window-of-opportunity biomarker study of etodolac in resectable breast cancer. Cancer Med. 2015 Oct; 4(10):1583-8. PMID: 26275572.
      View in: PubMed
    23. Shinchi H, Crain B, Yao S, Chan M, Zhang SS, Ahmadiiveli A, Suda Y, Hayashi T, Cottam HB, Carson DA. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19; 26(8):1713-23. PMID: 26193334.
      View in: PubMed
    24. Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam HB, Carson DA, Corr M. Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes. PLoS One. 2015; 10(6):e0129867. PMID: 26076454.
      View in: PubMed
    25. Choi MY, Widhopf GF, Wu CC, Cui B, Lao F, Sadarangani A, Cavagnaro J, Prussak C, Carson DA, Jamieson C, Kipps TJ. Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15 Suppl:S167-9. PMID: 26297272.
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    26. Barrett CL, DeBoever C, Jepsen K, Saenz CC, Carson DA, Frazer KA. Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):E3050-7. PMID: 26015570.
      View in: PubMed
    27. DeBoever C, Ghia EM, Shepard PJ, Rassenti L, Barrett CL, Jepsen K, Jamieson CH, Carson D, Kipps TJ, Frazer KA. Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers. PLoS Comput Biol. 2015 Mar; 11(3):e1004105. PMID: 25768983.
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    28. Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015 Mar; 89(6):3221-35. PMID: 25568203.
      View in: PubMed
    29. Zhang S, Cui B, Lai H, Liu G, Ghia EM, Widhopf GF, Zhang Z, Wu CC, Chen L, Wu R, Schwab R, Carson DA, Kipps TJ. Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17266-71. PMID: 25411317.
      View in: PubMed
    30. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. PMID: 25288184.
      View in: PubMed
    31. Saenz R, Futalan D, Leutenez L, Eekhout F, Fecteau JF, Sundelius S, Sundqvist S, Larsson M, Hayashi T, Minev B, Carson D, Esener S, Messmer B, Messmer D. TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant. J Transl Med. 2014 Aug 14; 12:211. PMID: 25123824.
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    32. Baghdadchi S, Liu K, Knapp J, Prager G, Graves S, Akrami K, Manuel R, Bastos R, Reid E, Carson D, Esener S, Carson J, Liu YT. An innovative system for 3D clinical photography in the resource-limited settings. J Transl Med. 2014 Jun 15; 12:169. PMID: 24929434.
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    33. Hayashi T, Crain B, Yao S, Caneda CD, Cottam HB, Chan M, Corr M, Carson DA. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014 Aug; 350(2):330-40. PMID: 24893985.
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    34. Fernandez A, Huggins IJ, Perna L, Brafman D, Lu D, Yao S, Gaasterland T, Carson DA, Willert K. The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1409-14. PMID: 24474766.
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    35. Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T. Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand. J Innate Immun. 2014; 6(3):315-24. PMID: 24192551.
      View in: PubMed
    36. DeBoever C, Reid EG, Smith EN, Wang X, Dumaop W, Harismendy O, Carson D, Richman D, Masliah E, Frazer KA. Whole transcriptome sequencing enables discovery and analysis of viruses in archived primary central nervous system lymphomas. PLoS One. 2013; 8(9):e73956. PMID: 24023918.
      View in: PubMed
    37. Crain B, Yao S, Keophilaone V, Promessi V, Kang M, Barberis A, Maj R, Mura E, Passini N, Holldack J, Ochoa R, Cottam HB, Carson DA, Hayashi T. Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. Eur J Dermatol. 2013 Sep-Oct; 23(5):618-28. PMID: 24225049.
      View in: PubMed
    38. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. PMID: 23656327.
      View in: PubMed
    39. Barrett CL, Schwab RB, Jung H, Crain B, Goff DJ, Jamieson CH, Thistlethwaite PA, Harismendy O, Carson DA, Frazer KA. Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. PLoS One. 2013; 8(3):e58714. PMID: 23527012.
      View in: PubMed
    40. Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam HB, Carson DA, Corr M. Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. PLoS One. 2012; 7(9):e45860. PMID: 23029281.
      View in: PubMed
    41. Wu RP, Li H, Rassenti LZ, Hayashi T, Wu CN, Kipps TJ, Messer K, Carson DA. Increased aldehyde dehydrogenase activity in high-risk chronic lymphocytic leukemia. Leuk Lymphoma. 2013 Feb; 54(2):400-2. PMID: 22784365.
      View in: PubMed
    42. Pu M, Hayashi T, Cottam H, Mulvaney J, Arkin M, Corr M, Carson D, Messer K. Analysis of high-throughput screening assays using cluster enrichment. Stat Med. 2012 Dec 30; 31(30):4175-89. PMID: 22763983.
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    43. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. PMID: 22768113.
      View in: PubMed
    44. Norton JT, Hayashi T, Crain B, Cho JS, Miller LS, Corr M, Carson DA. Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1. J Immunol. 2012 Apr 01; 188(7):2977-80. PMID: 22387558.
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    45. Kim Y, Gast SM, Endo T, Lu D, Carson D, Schmidt-Wolf IG. In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma. Leuk Res. 2012 May; 36(5):598-600. PMID: 22386728.
      View in: PubMed
    46. Hayashi T, Yao S, Crain B, Chan M, Cottam HB, Lao F, Carson DA, Corr M. Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand. Mediators Inflamm. 2012; 2012:262394. PMID: 22619481.
      View in: PubMed
    47. Kim Y, Schmidt M, Endo T, Lu D, Carson D, Schmidt-Wolf IG. Targeting the Wnt/beta-catenin pathway with the antifungal agent ciclopirox olamine in a murine myeloma model. In Vivo. 2011 Nov-Dec; 25(6):887-93. PMID: 22021681.
      View in: PubMed
    48. Zinkernagel AS, Hruz P, Uchiyama S, von Köckritz-Blickwede M, Schuepbach RA, Hayashi T, Carson DA, Nizet V. Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections. J Innate Immun. 2012; 4(2):213-8. PMID: 21860217.
      View in: PubMed
    49. Lu D, Carson DA. Inhibition of Wnt signaling and cancer stem cells. Oncotarget. 2011 Aug; 2(8):587. PMID: 21860066.
      View in: PubMed
    50. Lu D, Choi MY, Yu J, Castro JE, Kipps TJ, Carson DA. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13253-7. PMID: 21788521.
      View in: PubMed
    51. Nicolaou KC, Ellery SP, Rivas F, Saye K, Rogers E, Workinger TJ, Schallenberger M, Tawatao R, Montero A, Hessell A, Romesberg F, Carson D, Burton D. Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues. Bioorg Med Chem. 2011 Sep 15; 19(18):5648-69. PMID: 21840722.
      View in: PubMed
    52. Norton JT, Hayashi T, Crain B, Corr M, Carson DA. Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11163-8. PMID: 21690387.
      View in: PubMed
    53. Schmidt M, Kim Y, Gast SM, Endo T, Lu D, Carson D, Schmidt-Wolf IG. Increased in vivo efficacy of lenalidomide and thalidomide by addition of ethacrynic acid. In Vivo. 2011 May-Jun; 25(3):325-33. PMID: 21576405.
      View in: PubMed
    54. Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, Tawatao RI, Kalenian K, Zhang Y, Hayashi Y, Lao FS, Cottam HB, Carson DA. Synthesis and characterization of PEGylated toll like receptor 7 ligands. Bioconjug Chem. 2011 Mar 16; 22(3):445-54. PMID: 21338093.
      View in: PubMed
    55. Kim Y, Reifenberger G, Lu D, Endo T, Carson DA, Gast SM, Meschenmoser K, Nowak M, Schmidt-Wolf IG. Influencing the Wnt signaling pathway in multiple myeloma. Anticancer Res. 2011 Feb; 31(2):725-30. PMID: 21378363.
      View in: PubMed
    56. Hayashi T, Chan M, Norton JT, Wu CC, Yao S, Cottam HB, Tawatao RI, Corr M, Carson DA, Daniels GA. Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2. Melanoma Res. 2011 Feb; 21(1):66-75. PMID: 21030882.
      View in: PubMed
    57. Kim Y, Alpmann P, Blaum-Feder S, Krämer S, Endo T, Lu D, Carson D, Schmidt-Wolf IG. Increased in vivo efficacy of lenalidomide by addition of piroctone olamine. In Vivo. 2011 Jan-Feb; 25(1):99-103. PMID: 21282741.
      View in: PubMed
    58. Kim Y, Alpmann P, Blaum-Feder S, Krämer S, Endo T, Lu D, Carson D, Schmidt-Wolf IG. In vivo efficacy of griseofulvin against multiple myeloma. Leuk Res. 2011 Aug; 35(8):1070-3. PMID: 21112630.
      View in: PubMed
    59. Zhang Y, Elliot G, Saldanha A, Tsigelny I, Carson D, Wrasidlo W. Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid. Beilstein J Org Chem. 2010 Sep 01; 6:742-7. PMID: 20978615.
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    60. Wu RP, Hayashi T, Cottam HB, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab RB, Carson DA. Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7479-84. PMID: 20368435.
      View in: PubMed
    61. Lu D, Carson DA. Repression of beta-catenin signaling by PPAR gamma ligands. Eur J Pharmacol. 2010 Jun 25; 636(1-3):198-202. PMID: 20303941.
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    62. Hayashi T, Crain B, Corr M, Chan M, Cottam HB, Maj R, Barberis A, Leoni L, Carson DA. Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. Int J Urol. 2010 May; 17(5):483-90. PMID: 20337728.
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    63. Bashir A, Lu Q, Carson D, Raphael BJ, Liu YT, Bafna V. Optimizing PCR assays for DNA-based cancer diagnostics. J Comput Biol. 2010 Mar; 17(3):369-81. PMID: 20377451.
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    64. Lu D, Liu JX, Endo T, Zhou H, Yao S, Willert K, Schmidt-Wolf IG, Kipps TJ, Carson DA. Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14; 4(12):e8294. PMID: 20011538.
      View in: PubMed
    65. Lu D, Carson DA. Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. BMC Pharmacol. 2009 Nov 30; 9:13. PMID: 19948059.
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    66. Yang D, Pornpattananangkul D, Nakatsuji T, Chan M, Carson D, Huang CM, Zhang L. The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. Biomaterials. 2009 Oct; 30(30):6035-40. PMID: 19665786.
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    67. Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, Corr M, Wrasidlo W, Cottam HB, Carson DA. Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem. 2009 Jun; 20(6):1194-200. PMID: 19445505.
      View in: PubMed
    68. Hayashi T, Gray CS, Chan M, Tawatao RI, Ronacher L, McGargill MA, Datta SK, Carson DA, Corr M. Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2764-9. PMID: 19188597.
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    69. Jin G, Lu D, Yao S, Wu CC, Liu JX, Carson DA, Cottam HB. Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):606-9. PMID: 19121941.
      View in: PubMed
    70. Schmidt M, Sievers E, Endo T, Lu D, Carson D, Schmidt-Wolf IG. Targeting Wnt pathway in lymphoma and myeloma cells. Br J Haematol. 2009 Mar; 144(5):796-8. PMID: 19036118.
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    71. Lu Q, Nunez E, Lin C, Christensen K, Downs T, Carson DA, Wang-Rodriguez J, Liu YT. A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variants. Nucleic Acids Res. 2008 Nov; 36(20):e130. PMID: 18794177.
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    72. Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M. In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell Immunol. 2008 Feb; 251(2):78-85. PMID: 18495099.
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    73. Hayashi T, Cottam HB, Chan M, Jin G, Tawatao RI, Crain B, Ronacher L, Messer K, Carson DA, Corr M. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R123-32. PMID: 18480244.
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    74. Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE, Widhopf GF, Rassenti LZ, Cantwell MJ, Prussak CE, Carson DA, Kipps TJ. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):3047-52. PMID: 18287027.
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    75. Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson DA, Stupack DG. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2313-8. PMID: 18268346.
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    76. Livengood AJ, Wu CC, Carson DA. Opposing roles of RNA receptors TLR3 and RIG-I in the inflammatory response to double-stranded RNA in a Kaposi's sarcoma cell line. Cell Immunol. 2007 Oct; 249(2):55-62. PMID: 18155685.
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    77. Bashir A, Liu YT, Raphael BJ, Carson D, Bafna V. Optimization of primer design for the detection of variable genomic lesions in cancer. Bioinformatics. 2007 Nov 01; 23(21):2807-15. PMID: 17766270.
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    78. Liu YT, Carson DA. A novel approach for determining cancer genomic breakpoints in the presence of normal DNA. PLoS One. 2007 Apr 18; 2(4):e380. PMID: 17440616.
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    79. Wu CC, Hayashi T, Takabayashi K, Sabet M, Smee DF, Guiney DD, Cottam HB, Carson DA. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3990-5. PMID: 17360465.
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    80. Jin G, Wu CC, Tawatao RI, Chan M, Carson DA, Cottam HB. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. Bioorg Med Chem Lett. 2006 Sep 01; 16(17):4559-63. PMID: 16784848.
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    81. Barnard DL, Day CW, Bailey K, Heiner M, Montgomery R, Lauridsen L, Winslow S, Hoopes J, Li JK, Lee J, Carson DA, Cottam HB, Sidwell RW. Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral Res. 2006 Aug; 71(1):53-63. PMID: 16621037.
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    82. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1828-33. PMID: 16446426.
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    83. Jin G, Wu CC, Carson DA, Cottam HB. Guanosine analog in the pyrido[2,3-d]pyrimidine ring system as a potential toll-like receptor agonist. Nucleosides Nucleotides Nucleic Acids. 2006; 25(12):1391-7. PMID: 17067960.
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    84. Lu D, Cottam HB, Corr M, Carson DA. Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18567-71. PMID: 16352713.
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    85. Barchéchath SD, Tawatao RI, Corr M, Carson DA, Cottam HB. Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. J Med Chem. 2005 Oct 06; 48(20):6409-22. PMID: 16190767.
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    86. Barchéchath SD, Tawatao RI, Corr M, Carson DA, Cottam HB. Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. Bioorg Med Chem Lett. 2005 Apr 01; 15(7):1785-8. PMID: 15780606.
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    87. Kolluri SK, Corr M, James SY, Bernasconi M, Lu D, Liu W, Cottam HB, Leoni LM, Carson DA, Zhang XK. The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2525-30. PMID: 15699354.
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    88. Ohata J, Zvaifler NJ, Nishio M, Boyle DL, Kalled SL, Carson DA, Kipps TJ. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol. 2005 Jan 15; 174(2):864-70. PMID: 15634908.
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    89. Diccianni MB, Yu J, Meppelink G, de Vries M, Shao L, Gebauer S, Shih H, Roberts W, Kilcoin NP, Pullen J, Carson DA, Yu AL. 3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner. J Exp Ther Oncol. 2004 Oct; 4(3):223-37. PMID: 15724842.
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    90. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide DH, Carson DA, Raz E. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 2004 Jul; 114(2):270-9. PMID: 15254594.
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    91. Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, Ferreira A, Ciesielski C, Carson DA, Corr M. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9757-62. PMID: 15210948.
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    92. Wu CC, Lee J, Raz E, Corr M, Carson DA. Necessity of oligonucleotide aggregation for toll-like receptor 9 activation. J Biol Chem. 2004 Aug 06; 279(32):33071-8. PMID: 15184382.
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    93. Hedvat M, Jain A, Carson DA, Leoni LM, Huang G, Holden S, Lu D, Corr M, Fox W, Agus DB. Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma. Cancer Cell. 2004 Jun; 5(6):565-74. PMID: 15193259.
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    94. Lu D, Zhao Y, Tawatao R, Cottam HB, Sen M, Leoni LM, Kipps TJ, Corr M, Carson DA. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3118-23. PMID: 14973184.
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    95. Sen M, Cheng YH, Goldring MB, Lotz MK, Carson DA. WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum. 2004 Feb; 50(2):488-97. PMID: 14872491.
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    96. Adachi S, Leoni LM, Carson DA, Nakahata T. Apoptosis induced by molecular targeting therapy in hematological malignancies. Acta Haematol. 2004; 111(1-2):107-23. PMID: 14646349.
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    97. Silverman GJ, Carson DA. Roles of B cells in rheumatoid arthritis. Arthritis Res Ther. 2003; 5 Suppl 4:S1-6. PMID: 15180890.
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    98. Wu CC, Castro JE, Motta M, Cottam HB, Kyburz D, Kipps TJ, Corr M, Carson DA. Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells. Hum Gene Ther. 2003 Jun 10; 14(9):849-60. PMID: 12828856.
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    99. Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6646-51. PMID: 12738885.
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    100. Kyburz D, Rethage J, Seibl R, Lauener R, Gay RE, Carson DA, Gay S. Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling. Arthritis Rheum. 2003 Mar; 48(3):642-50. PMID: 12632416.
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    101. Carson DA, Leoni LM. Hairy-cell leukaemia as a model for drug development. Best Pract Res Clin Haematol. 2003 Mar; 16(1):83-9. PMID: 12670467.
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    102. Sen M, Reifert J, Lauterbach K, Wolf V, Rubin JS, Corr M, Carson DA. Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum. 2002 Nov; 46(11):2867-77. PMID: 12428226.
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    103. Rhee CS, Sen M, Lu D, Wu C, Leoni L, Rubin J, Corr M, Carson DA. Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene. 2002 Sep 26; 21(43):6598-605. PMID: 12242657.
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    104. Shih H, Cottam HB, Carson DA. Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors. Chem Pharm Bull (Tokyo). 2002 Mar; 50(3):364-7. PMID: 11911199.
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    105. Ronaghy A, Prakken BJ, Takabayashi K, Firestein GS, Boyle D, Zvailfler NJ, Roord ST, Albani S, Carson DA, Raz E. Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol. 2002 Jan 01; 168(1):51-6. PMID: 11751945.
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    106. Carson DA. An infectious origin of extraskeletal calcification. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):7846-7. PMID: 9653101.
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