BiographyDr. Caligiuri attended the University of Wisconsin, Madison where he received a Ph.D. in neuroscience with an emphasis in motor control. His current research focuses on motor control in neuropsychiatric disorders, developing quantitative instrumentation for assessing dyskinesia and parkinsonism, and understanding the interplay between neuromotor dyscontrol and psychiatric illness. Particular emphasis is placed on validating measures of handwriting kinematics for quantitative assessment of neuropsychiatric movement disorders.
Research InterestsDr Caligiuri’s research focuses on understanding how motor function and impairment can be useful in the diagnosis and treatment of affective and psychotic illnesses. Significant research contributions include: the demonstration that early drug-induced parkinsonism can predict long-term persistent movement disorders in patients treated with antipsychotics; finding that affective state in bipolar disorder may be related to a disturbance of inhibitory regulation within the basal ganglia and that antipsychotics and or mood stabilizers normalize cortical and subcortical hyperactivity in patients with bipolar disorder; development of a portable, simple to use transducer for quantifying tremor; and demonstrating that measures of handwriting kinematics can detect subtle differences in EPS liability between various antipsychotic medications. His current research aims to understand the effects of drugs, disease, and aging on handwriting kinematics to enable the forensic community to better understand these contributions when authenticating signatures.
Clinical FocusDr. Caligiuri’s clinical focus is on movement disorders with particular emphasis of differentiating idiopathic or degenerative disorders from medication-induced disorders and developing technologies for the rapid quantification of extrapyramidal motor signs such as tremor, dyskinesia and bradykinesia.