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Michael Caligiuri

TitleRecall Faculty
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Address9500 Gilman Drive #0052
La Jolla CA 92093
Phone858-657-5100
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    Biography

    Dr. Caligiuri attended the University of Wisconsin, Madison where he received a Ph.D. in neuroscience with an emphasis in motor control. His current research focuses on motor control in neuropsychiatric disorders, developing quantitative instrumentation for assessing dyskinesia and parkinsonism, and understanding the interplay between neuromotor dyscontrol and psychiatric illness. Particular emphasis is placed on validating measures of handwriting kinematics for quantitative assessment of neuropsychiatric movement disorders.

    Research Interests

    Dr Caligiuri’s research focuses on understanding how motor function and impairment can be useful in the diagnosis and treatment of affective and psychotic illnesses. Significant research contributions include: the demonstration that early drug-induced parkinsonism can predict long-term persistent movement disorders in patients treated with antipsychotics; finding that affective state in bipolar disorder may be related to a disturbance of inhibitory regulation within the basal ganglia and that antipsychotics and or mood stabilizers normalize cortical and subcortical hyperactivity in patients with bipolar disorder; development of a portable, simple to use transducer for quantifying tremor; and demonstrating that measures of handwriting kinematics can detect subtle differences in EPS liability between various antipsychotic medications. His current research aims to understand the effects of drugs, disease, and aging on handwriting kinematics to enable the forensic community to better understand these contributions when authenticating signatures.

    Clinical Focus

    Dr. Caligiuri’s clinical focus is on movement disorders with particular emphasis of differentiating idiopathic or degenerative disorders from medication-induced disorders and developing technologies for the rapid quantification of extrapyramidal motor signs such as tremor, dyskinesia and bradykinesia.


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    Collapse Research Activities and Funding
    EPS AND PREDICTORS OF PSYCHOSIS IN ALZHEIMERS DISEASE
    NIH/NIA R01AG014291Sep 30, 1996 - Aug 31, 2002
    Role: Principal Investigator
    QUANTITATIVE STUDIES OF NEUROLEPTIC-INDUCED PARKINSONISM
    NIH/NIMH R29MH045959Apr 1, 1991 - Mar 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Caligiuri M, Allen K, Buscher N, Denney L, Gates C, Kantelo K, Magit A, Sak R, Firestein GS, Fontanesi J. A multisite study of performance drivers among institutional review boards. J Clin Transl Sci. 2017 Jun; 1(3):192-197. PMID: 29093967.
      View in: PubMed
    2. Caligiuri M, Teulings HL, Dean CE, Lohr JB. A quantitative measure of handwriting dysfluency for assessing tardive dyskinesia. J Clin Psychopharmacol. 2015 Apr; 35(2):168-74. PMID: 25679121; PMCID: PMC4344392.
    3. Mohammed L, Found B, Caligiuri M, Rogers D. Dynamic characteristics of signatures: effects of writer style on genuine and simulated signatures. J Forensic Sci. 2015 Jan; 60(1):89-94. PMID: 25420668.
      View in: PubMed
    4. Caligiuri M, Kim C, Landy KM. Kinematics of signature writing in healthy aging. J Forensic Sci. 2014 Jul; 59(4):1020-4. PMID: 24673648; PMCID: PMC4077921.
    5. Dean DJ, Teulings HL, Caligiuri M, Mittal VA. Handwriting analysis indicates spontaneous dyskinesias in neuroleptic naïve adolescents at high risk for psychosis. J Vis Exp. 2013 Nov 21; (81):e50852. PMID: 24300590; PMCID: PMC3902788.
    6. Lohr JB, Liu L, Caligiuri M, Kash TP, May TA, Murphy JD, Ancoli-Israel S. Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study. Schizophr Res. 2013 Oct; 150(1):289-96. PMID: 23938173.
      View in: PubMed
    7. Caligiuri M, Mohammed LA, Found B, Rogers D. Nonadherence to the isochrony principle in forged signatures. Forensic Sci Int. 2012 Nov 30; 223(1-3):228-32. PMID: 23084659.
      View in: PubMed
    8. Lohr JB, May T, Caligiuri M. Quantitative assessment of motor abnormalities in untreated patients with major depressive disorder. J Affect Disord. 2013 Mar 20; 146(1):84-90. PMID: 22985485; PMCID: PMC4283485.
    9. Brown GG, Lee JS, Strigo IA, Caligiuri M, Meloy MJ, Lohr J. Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study. Psychiatry Res. 2011 Nov 30; 194(2):149-56. PMID: 21924872; PMCID: PMC3196272.
    10. Mittal VA, Dean DJ, Pelletier A, Caligiuri M. Associations between spontaneous movement abnormalities and psychotic-like experiences in the general population. Schizophr Res. 2011 Nov; 132(2-3):194-6. PMID: 21782390; PMCID: PMC3195924.
    11. Mohammed LA, Found B, Caligiuri M, Rogers D. The dynamic character of disguise behavior for text-based, mixed, and stylized signatures. J Forensic Sci. 2011 Jan; 56 Suppl 1:S136-41. PMID: 20950317.
      View in: PubMed
    12. Caligiuri M, Teulings HL, Dean CE, Niculescu AB, Lohr JB. Handwriting movement kinematics for quantifying extrapyramidal side effects in patients treated with atypical antipsychotics. Psychiatry Res. 2010 May 15; 177(1-2):77-83. PMID: 20381875; PMCID: PMC2859992.
    13. Caligiuri M, Teulings HL, Dean CE, Niculescu AB, Lohr J. Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone. Hum Mov Sci. 2009 Oct; 28(5):633-42. PMID: 19692133; PMCID: PMC2749075.
    14. Henry J, Palmer BW, Palinkas L, Glorioso DK, Caligiuri M, Jeste DV. Reformed consent: adapting to new media and research participant preferences. IRB. 2009 Mar-Apr; 31(2):1-8. PMID: 19402337; PMCID: PMC2743865.
    15. Cortese L, Caligiuri M, Williams R, Schieldrop P, Manchanda R, Malla A, Harricharan R. Reduction in neuroleptic-induced movement disorders after a switch to quetiapine in patients with schizophrenia. J Clin Psychopharmacol. 2008 Feb; 28(1):69-73. PMID: 18204344.
      View in: PubMed
    16. Freedman SE, Maas E, Caligiuri M, Wulf G, Robin DA. Internal versus external: oral-motor performance as a function of attentional focus. J Speech Lang Hear Res. 2007 Feb; 50(1):131-6. PMID: 17344554.
      View in: PubMed
    17. Dean CE, Kuskowski MA, Caligiuri M. Predictors of neuroleptic-induced dyskinesia and parkinsonism: the influence of measurement methods and definitions. J Clin Psychopharmacol. 2006 Dec; 26(6):560-5. PMID: 17110811.
      View in: PubMed
    18. Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ, Caligiuri M, Lohr JB. PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 05; 141B(6):653-62. PMID: 16838358.
      View in: PubMed
    19. Lohr JB, Hellige JB, Cherry BJ, Lulow L, Kwok W, Caligiuri M. Impaired hemispheric communication in schizophrenia: a study using the consonant-vowel-consonant task. Schizophr Res. 2006 Oct; 87(1-3):279-88. PMID: 16822652.
      View in: PubMed
    20. Caligiuri M, Teulings HL, Filoteo JV, Song D, Lohr JB. Quantitative measurement of handwriting in the assessment of drug-induced parkinsonism. Hum Mov Sci. 2006 Oct; 25(4-5):510-22. PMID: 16647772.
      View in: PubMed
    21. Caligiuri M, Brown GG, Meloy MJ, Eberson S, Niculescu AB, Lohr JB. Striatopallidal regulation of affect in bipolar disorder. J Affect Disord. 2006 Apr; 91(2-3):235-42. PMID: 16503055.
      View in: PubMed
    22. Ozdemir V, Aklillu E, Mee S, Bertilsson L, Albers LJ, Graham JE, Caligiuri M, Lohr JB, Reist C. Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines. Expert Opin Pharmacother. 2006 Feb; 7(2):119-33. PMID: 16433578.
      View in: PubMed
    23. Lohr JB, Caligiuri M. Abnormalities in motor physiology in bipolar disorder. J Neuropsychiatry Clin Neurosci. 2006; 18(3):342-9. PMID: 16963583.
      View in: PubMed
    24. Caligiuri M, Buitenhuys C. Do preclinical findings of methamphetamine-induced motor abnormalities translate to an observable clinical phenotype? Neuropsychopharmacology. 2005 Dec; 30(12):2125-34. PMID: 16123755.
      View in: PubMed
    25. Caligiuri M, Hellige JB, Cherry BJ, Kwok W, Lulow LL, Lohr JB. Lateralized cognitive dysfunction and psychotic symptoms in schizophrenia. Schizophr Res. 2005 Dec 15; 80(2-3):151-61. PMID: 16125374.
      View in: PubMed
    26. Cortese L, Caligiuri M, Malla AK, Manchanda R, Takhar J, Haricharan R. Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naive schizophrenia patients. Schizophr Res. 2005 Jun 01; 75(1):65-75. PMID: 15820325.
      View in: PubMed
    27. Caligiuri M, Tripp RM. A portable hand-held device for quantifying and standardizing tremor assessment. J Med Eng Technol. 2004 Nov-Dec; 28(6):254-62. PMID: 15513743.
      View in: PubMed
    28. Caligiuri M, Brown GG, Meloy MJ, Eyler LT, Kindermann SS, Eberson S, Frank LR, Lohr JB. A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder. Bipolar Disord. 2004 Jun; 6(3):183-96. PMID: 15117397.
      View in: PubMed
    29. Dean CE, Russell JM, Kuskowski MA, Caligiuri M, Nugent SM. Clinical rating scales and instruments: how do they compare in assessing abnormal, involuntary movements? J Clin Psychopharmacol. 2004 Jun; 24(3):298-304. PMID: 15118484.
      View in: PubMed
    30. Caligiuri M, Jeste DV. Association of diabetes with dyskinesia in older psychosis patients. Psychopharmacology (Berl). 2004 Nov; 176(3-4):281-6. PMID: 15138754.
      View in: PubMed
    31. Brown GG, Caligiuri M, Meloy MJ, Eberson SC, Kindermann SS, Frank LR, Eyler Zorrilla LT, Lohr JB. Functional brain asymmetries during visuomotor tracking. J Clin Exp Neuropsychol. 2004 May; 26(3):356-68. PMID: 15512926.
      View in: PubMed
    32. Caligiuri M, Gentili V, Eberson S, Kelsoe J, Rapaport M, Gillin JC. A quantitative neuromotor predictor of antidepressant non-response in patients with major depression. J Affect Disord. 2003 Nov; 77(2):135-41. PMID: 14607390.
      View in: PubMed
    33. Caligiuri M, Peavy G, Salmon DP, Galasko DR, Thal LJ. Neuromotor abnormalities and risk for psychosis in Alzheimer's disease. Neurology. 2003 Oct 14; 61(7):954-8. PMID: 14557567.
      View in: PubMed
    34. Caligiuri M, Brown GG, Meloy MJ, Eberson SC, Kindermann SS, Frank LR, Zorrilla LE, Lohr JB. An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder. Psychiatry Res. 2003 Jul 30; 123(3):171-82. PMID: 12928105.
      View in: PubMed
    35. Lohr JB, Caligiuri M, Edson R, Lavori P, Adler LA, Rotrosen J, Hitzemann R. Treatment predictors of extrapyramidal side effects in patients with tardive dyskinesia: results from Veterans Affairs Cooperative Study 394. J Clin Psychopharmacol. 2002 Apr; 22(2):196-200. PMID: 11910266.
      View in: PubMed
    36. Caligiuri M, Peavy G, Galasko DR. Extrapyramidal signs and cognitive abilities in Alzheimer's disease. Int J Geriatr Psychiatry. 2001 Sep; 16(9):907-11. PMID: 11571772.
      View in: PubMed
    37. Caligiuri M, Jeste DV, Lacro JP. Antipsychotic-Induced movement disorders in the elderly: epidemiology and treatment recommendations. Drugs Aging. 2000 Nov; 17(5):363-84. PMID: 11190417.
      View in: PubMed
    38. Caligiuri M, Peavy G. An instrumental study of the relationship between extrapyramidal signs and psychosis in Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 2000; 12(1):34-9. PMID: 10678510.
      View in: PubMed
    39. Caligiuri M, Ellwanger J. Motor and cognitive aspects of motor retardation in depression. J Affect Disord. 2000 Jan-Mar; 57(1-3):83-93. PMID: 10708819.
      View in: PubMed
    40. Caligiuri M, Lacro JP, Jeste DV. Incidence and predictors of drug-induced parkinsonism in older psychiatric patients treated with very low doses of neuroleptics. J Clin Psychopharmacol. 1999 Aug; 19(4):322-8. PMID: 10440459.
      View in: PubMed
    41. Caligiuri M, Lohr JB, Ruck RK. Scaling of movement velocity: a measure of neuromotor retardation in individuals with psychopathology. Psychophysiology. 1998 Jul; 35(4):431-7. PMID: 9643057.
      View in: PubMed
    42. Caligiuri M, Rockwell E, Jeste DV. Extrapyramidal side effects in patients with Alzheimer's disease treated with low-dose neuroleptic medication. Am J Geriatr Psychiatry. 1998; 6(1):75-82. PMID: 9469217.
      View in: PubMed
    43. Caligiuri M, Lohr JB. Instrumental motor predictors of neuroleptic-induced parkinsonism in newly medicated schizophrenia patients. J Neuropsychiatry Clin Neurosci. 1997; 9(4):562-7. PMID: 9447497.
      View in: PubMed
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