Michael Caligiuri

Title(s)Recall Faculty, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Dr. Caligiuri attended the University of Wisconsin, Madison where he received a Ph.D. in neuroscience with an emphasis in motor control. His current research focuses on motor control in neuropsychiatric disorders, developing quantitative instrumentation for assessing dyskinesia and parkinsonism, and understanding the interplay between neuromotor dyscontrol and psychiatric illness. Particular emphasis is placed on validating measures of handwriting kinematics for quantitative assessment of neuropsychiatric movement disorders.

    Research Interests

    Dr Caligiuri’s research focuses on understanding how motor function and impairment can be useful in the diagnosis and treatment of affective and psychotic illnesses. Significant research contributions include: the demonstration that early drug-induced parkinsonism can predict long-term persistent movement disorders in patients treated with antipsychotics; finding that affective state in bipolar disorder may be related to a disturbance of inhibitory regulation within the basal ganglia and that antipsychotics and or mood stabilizers normalize cortical and subcortical hyperactivity in patients with bipolar disorder; development of a portable, simple to use transducer for quantifying tremor; and demonstrating that measures of handwriting kinematics can detect subtle differences in EPS liability between various antipsychotic medications. His current research aims to understand the effects of drugs, disease, and aging on handwriting kinematics to enable the forensic community to better understand these contributions when authenticating signatures.

    Clinical Focus

    Dr. Caligiuri’s clinical focus is on movement disorders with particular emphasis of differentiating idiopathic or degenerative disorders from medication-induced disorders and developing technologies for the rapid quantification of extrapyramidal motor signs such as tremor, dyskinesia and bradykinesia.

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    NIH/NIA R01AG014291Sep 30, 1996 - Aug 31, 2002
    Role: Principal Investigator
    NIH/NIMH R29MH045959Apr 1, 1991 - Mar 31, 1996
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Use of an Automated System to Evaluate Feature Dissimilarities in Handwriting Under a Two-Stage Evaluative Process*,†. J Forensic Sci. 2020 Aug 24. Fuglsby C, Saunders C, Ommen DM, Caligiuri MP. PMID: 32835414.
      View in: PubMed   Mentions:    Fields:    
    2. Exploring the Relationship of Transdiagnostic Mood and Psychosis Symptom Domains with Motor Dysfunction. Neuropsychobiology. 2020; 79(4-5):301-312. Kent JS, Disner SG, Van Voorhis AC, Uroševic S, Caligiuri MP, Sponheim SR. PMID: 31851987.
      View in: PubMed   Mentions:    Fields:    
    3. Handwriting Movement Abnormalities in Symptomatic and Premanifest Huntington's Disease. Mov Disord Clin Pract. 2019 Sep; 6(7):586-592. Caligiuri M, Snell C, Park S, Corey-Bloom J. PMID: 31538093.
      View in: PubMed   Mentions:
    4. Signature dynamics in Alzheimer's disease. Forensic Sci Int. 2019 Sep; 302:109880. Caligiuri MP, Mohammed L. PMID: 31390576.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. The nature of bradykinesia in schizophrenia treated with antipsychotics. Psychiatry Res. 2019 03; 273:537-543. Caligiuri MP, Teulings HL, Dean CE, Lohr JB. PMID: 30710809.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Instrument-based assessment of motor function yields no evidence of dyskinesia in adult first-degree biological relatives of individuals with schizophrenia and schizoaffective disorder. Psychiatry Res. 2019 02; 272:135-140. Kent JS, Caligiuri MP, Skorheim MK, Lano TJ, Mittal VA, Sponheim SR. PMID: 30580137.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. A multisite study of performance drivers among institutional review boards. J Clin Transl Sci. 2017 Jun; 1(3):192-197. Caligiuri M, Allen K, Buscher N, Denney L, Gates C, Kantelo K, Magit A, Sak R, Firestein GS, Fontanesi J. PMID: 29093967.
      View in: PubMed   Mentions:
    8. A quantitative measure of handwriting dysfluency for assessing tardive dyskinesia. J Clin Psychopharmacol. 2015 Apr; 35(2):168-74. Caligiuri MP, Teulings HL, Dean CE, Lohr JB. PMID: 25679121.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Dynamic characteristics of signatures: effects of writer style on genuine and simulated signatures. J Forensic Sci. 2015 Jan; 60(1):89-94. Mohammed L, Found B, Caligiuri M, Rogers D. PMID: 25420668.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Kinematics of signature writing in healthy aging. J Forensic Sci. 2014 Jul; 59(4):1020-4. Caligiuri MP, Kim C, Landy KM. PMID: 24673648.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Handwriting analysis indicates spontaneous dyskinesias in neuroleptic naïve adolescents at high risk for psychosis. J Vis Exp. 2013 Nov 21; (81):e50852. Dean DJ, Teulings HL, Caligiuri M, Mittal VA. PMID: 24300590.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    12. Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study. Schizophr Res. 2013 Oct; 150(1):289-96. Lohr JB, Liu L, Caligiuri MP, Kash TP, May TA, Murphy JD, Ancoli-Israel S. PMID: 23938173.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Nonadherence to the isochrony principle in forged signatures. Forensic Sci Int. 2012 Nov 30; 223(1-3):228-32. Caligiuri MP, Mohammed LA, Found B, Rogers D. PMID: 23084659.
      View in: PubMed   Mentions:    Fields:    
    14. Quantitative assessment of motor abnormalities in untreated patients with major depressive disorder. J Affect Disord. 2013 Mar 20; 146(1):84-90. Lohr JB, May T, Caligiuri MP. PMID: 22985485.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    15. Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study. Psychiatry Res. 2011 Nov 30; 194(2):149-56. Brown GG, Lee JS, Strigo IA, Caligiuri MP, Meloy MJ, Lohr J. PMID: 21924872.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    16. Associations between spontaneous movement abnormalities and psychotic-like experiences in the general population. Schizophr Res. 2011 Nov; 132(2-3):194-6. Mittal VA, Dean DJ, Pelletier A, Caligiuri M. PMID: 21782390.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    17. The dynamic character of disguise behavior for text-based, mixed, and stylized signatures. J Forensic Sci. 2011 Jan; 56 Suppl 1:S136-41. Mohammed LA, Found B, Caligiuri M, Rogers D. PMID: 20950317.
      View in: PubMed   Mentions:    Fields:    
    18. Handwriting movement kinematics for quantifying extrapyramidal side effects in patients treated with atypical antipsychotics. Psychiatry Res. 2010 May 15; 177(1-2):77-83. Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr JB. PMID: 20381875.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    19. Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone. Hum Mov Sci. 2009 Oct; 28(5):633-42. Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr J. PMID: 19692133.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    20. Reformed consent: adapting to new media and research participant preferences. IRB. 2009 Mar-Apr; 31(2):1-8. Henry J, Palmer BW, Palinkas L, Glorioso DK, Caligiuri MP, Jeste DV. PMID: 19402337.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    21. Reduction in neuroleptic-induced movement disorders after a switch to quetiapine in patients with schizophrenia. J Clin Psychopharmacol. 2008 Feb; 28(1):69-73. Cortese L, Caligiuri MP, Williams R, Schieldrop P, Manchanda R, Malla A, Harricharan R. PMID: 18204344.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Internal versus external: oral-motor performance as a function of attentional focus. J Speech Lang Hear Res. 2007 Feb; 50(1):131-6. Freedman SE, Maas E, Caligiuri MP, Wulf G, Robin DA. PMID: 17344554.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Predictors of neuroleptic-induced dyskinesia and parkinsonism: the influence of measurement methods and definitions. J Clin Psychopharmacol. 2006 Dec; 26(6):560-5. Dean CE, Kuskowski MA, Caligiuri MP. PMID: 17110811.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes. . 2006 Sep 05; 141B(6):653-62. Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ, Caligiuri MP, Lohr JB. PMID: 16838358.
      View in: PubMed   Mentions:
    25. Impaired hemispheric communication in schizophrenia: a study using the consonant-vowel-consonant task. Schizophr Res. 2006 Oct; 87(1-3):279-88. Lohr JB, Hellige JB, Cherry BJ, Lulow L, Kwok W, Caligiuri MP. PMID: 16822652.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Quantitative measurement of handwriting in the assessment of drug-induced parkinsonism. Hum Mov Sci. 2006 Oct; 25(4-5):510-22. Caligiuri MP, Teulings HL, Filoteo JV, Song D, Lohr JB. PMID: 16647772.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    27. Striatopallidal regulation of affect in bipolar disorder. J Affect Disord. 2006 Apr; 91(2-3):235-42. Caligiuri MP, Brown GG, Meloy MJ, Eberson S, Niculescu AB, Lohr JB. PMID: 16503055.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines. Expert Opin Pharmacother. 2006 Feb; 7(2):119-33. Ozdemir V, Aklillu E, Mee S, Bertilsson L, Albers LJ, Graham JE, Caligiuri M, Lohr JB, Reist C. PMID: 16433578.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Abnormalities in motor physiology in bipolar disorder. J Neuropsychiatry Clin Neurosci. 2006; 18(3):342-9. Lohr JB, Caligiuri MP. PMID: 16963583.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    30. Do preclinical findings of methamphetamine-induced motor abnormalities translate to an observable clinical phenotype? Neuropsychopharmacology. 2005 Dec; 30(12):2125-34. Caligiuri MP, Buitenhuys C. PMID: 16123755.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    31. Lateralized cognitive dysfunction and psychotic symptoms in schizophrenia. Schizophr Res. 2005 Dec 15; 80(2-3):151-61. Caligiuri MP, Hellige JB, Cherry BJ, Kwok W, Lulow LL, Lohr JB. PMID: 16125374.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    32. Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naive schizophrenia patients. Schizophr Res. 2005 Jun 01; 75(1):65-75. Cortese L, Caligiuri MP, Malla AK, Manchanda R, Takhar J, Haricharan R. PMID: 15820325.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    33. A portable hand-held device for quantifying and standardizing tremor assessment. J Med Eng Technol. 2004 Nov-Dec; 28(6):254-62. Caligiuri MP, Tripp RM. PMID: 15513743.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    34. Clinical rating scales and instruments: how do they compare in assessing abnormal, involuntary movements? J Clin Psychopharmacol. 2004 Jun; 24(3):298-304. Dean CE, Russell JM, Kuskowski MA, Caligiuri MP, Nugent SM. PMID: 15118484.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    35. A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder. Bipolar Disord. 2004 Jun; 6(3):183-96. Caligiuri MP, Brown GG, Meloy MJ, Eyler LT, Kindermann SS, Eberson S, Frank LR, Lohr JB. PMID: 15117397.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    36. Association of diabetes with dyskinesia in older psychosis patients. Psychopharmacology (Berl). 2004 Nov; 176(3-4):281-6. Caligiuri MP, Jeste DV. PMID: 15138754.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    37. Functional brain asymmetries during visuomotor tracking. J Clin Exp Neuropsychol. 2004 May; 26(3):356-68. Brown GG, Caligiuri M, Meloy MJ, Eberson SC, Kindermann SS, Frank LR, Eyler Zorrilla LT, Lohr JB. PMID: 15512926.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    38. A quantitative neuromotor predictor of antidepressant non-response in patients with major depression. J Affect Disord. 2003 Nov; 77(2):135-41. Caligiuri MP, Gentili V, Eberson S, Kelsoe J, Rapaport M, Gillin JC. PMID: 14607390.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsCTClinical Trials
    39. Neuromotor abnormalities and risk for psychosis in Alzheimer's disease. Neurology. 2003 Oct 14; 61(7):954-8. Caligiuri MP, Peavy G, Salmon DP, Galasko DR, Thal LJ. PMID: 14557567.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    40. An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder. Psychiatry Res. 2003 Jul 30; 123(3):171-82. Caligiuri MP, Brown GG, Meloy MJ, Eberson SC, Kindermann SS, Frank LR, Zorrilla LE, Lohr JB. PMID: 12928105.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    41. Treatment predictors of extrapyramidal side effects in patients with tardive dyskinesia: results from Veterans Affairs Cooperative Study 394. J Clin Psychopharmacol. 2002 Apr; 22(2):196-200. Lohr JB, Caligiuri MP, Edson R, Lavori P, Adler LA, Rotrosen J, Hitzemann R. PMID: 11910266.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Extrapyramidal signs and cognitive abilities in Alzheimer's disease. Int J Geriatr Psychiatry. 2001 Sep; 16(9):907-11. Caligiuri MP, Peavy G, Galasko DR. PMID: 11571772.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. Antipsychotic-Induced movement disorders in the elderly: epidemiology and treatment recommendations. Drugs Aging. 2000 Nov; 17(5):363-84. Caligiuri MR, Jeste DV, Lacro JP. PMID: 11190417.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    44. Motor and cognitive aspects of motor retardation in depression. J Affect Disord. 2000 Jan-Mar; 57(1-3):83-93. Caligiuri MP, Ellwanger J. PMID: 10708819.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    45. An instrumental study of the relationship between extrapyramidal signs and psychosis in Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 2000; 12(1):34-9. Caligiuri MP, Peavy G. PMID: 10678510.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Incidence and predictors of drug-induced parkinsonism in older psychiatric patients treated with very low doses of neuroleptics. J Clin Psychopharmacol. 1999 Aug; 19(4):322-8. Caligiuri MP, Lacro JP, Jeste DV. PMID: 10440459.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    47. Scaling of movement velocity: a measure of neuromotor retardation in individuals with psychopathology. Psychophysiology. 1998 Jul; 35(4):431-7. Caligiuri MP, Lohr JB, Ruck RK. PMID: 9643057.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    48. Extrapyramidal side effects in patients with Alzheimer's disease treated with low-dose neuroleptic medication. Am J Geriatr Psychiatry. 1998; 6(1):75-82. Caligiuri MP, Rockwell E, Jeste DV. PMID: 9469217.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    49. Instrumental motor predictors of neuroleptic-induced parkinsonism in newly medicated schizophrenia patients. J Neuropsychiatry Clin Neurosci. 1997; 9(4):562-7. Caligiuri MP, Lohr JB. PMID: 9447497.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
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