Jan Hughes-austin

Title(s)	Associate Professor, Orthopedic Surgery
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

education and training

University of California, San Diego, La Jolla, CA	Fellowship	12/2015	Cardiovascular Epidemiology
University of Colorado Anschutz Medical Campus, Aurora, CO	PhD	12/2011	Epidemiology
University of North Carolina at Chapel Hill, Chapel Hill, NC	MPT	12/2002	Physical Therapy
University of North Carolina at Chapel Hill, Chapel Hill, NC	BSPH	05/1999	Public Health Nutrition

awards and honors

National Institutes of Health	2018	NIH Loan Repayment Program
National Institutes of Health	2016	NIH Loan Repayment Program
Rheumatology Research Foundation	2014	Foundation Career Development Bridge Funding Award: K Bridge
Foundation for Physical Therapy	2014	Miami-Marquette Challenge Research Award
American Physical Therapy Association	2002	Mary McMillan Scholarship Award
University of North Carolina at Chapel Hill	2001	June C. Allcott Fellow
University of North Carolina at Chapel Hill	2000	June C. Allcott Fellow

Overview

keywords

Epidemiology, Rheumatoid Arthritis, Rheumatoid Arthritis - Related Autoimmunity, Cardiovascular Disease, Inflammation, Chronic Kidney Disease - Mineral and Bone Disorder, Bone Disease / Bone Health, Physical Therapy

Research

research activities and funding

Hip Fracture Pathology in Chronic Kidney Disease
NIH R01AG065876Mar 1, 2020 - Dec 31, 2024
Role: Principal Investigator

The Effect of Human Leukocyte Antigen Type on Associations between Antibodies to Citrullinated Protein Antigens (ACPA) and Myocardial Structure and Function
NIH R03HL146875Apr 1, 2019 - Mar 31, 2021
Role: Principal Investigator

Antibodies to Citrullinated Protein Antigens, CVD and Bone Disease in MESA
NIH K01HL122394Aug 15, 2015 - May 31, 2020
Role: Principal Investigator

Vertebral Bone Mineral Density, Inflamed Joints, and Physical Activity in First-Degree Relatives of Patients with Rheumatoid Arthritis
Foundation for Physical Therapy Miami-Marquette Challenge Research AwardJan 1, 2015 - Dec 31, 2016
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Associations of HLA-DRB1 shared epitope alleles with cardiovascular disease and events in a multi-ethnic community-living population: The multi-ethnic study of atherosclerosis (MESA). Hum Immunol. 2025 May; 86(3):111265. Kaur M, Katz R, Criqui MH, Corr M, Post WS, Budoff M, Morris GP, Hughes-Austin JM. PMID: 40068347.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Translation:Humans
Static histomorphometry parameters can identify bone turnover status in children and adults with chronic kidney disease. Bone. 2025 Jan; 190:117329. Hughes-Austin JM, Pereira RC, Jorgetti VD, Salusky IB, Ix JH. PMID: 39528063.

View in: PubMed Mentions: Fields:
Met Metabolism Ort Orthopedics
Translation:Humans
Serum reactivity to citrullinated protein/peptide antigens and left ventricular structure and function in the Multi-Ethnic Study of Atherosclerosis (MESA). PLoS One. 2023; 18(10):e0291967. Hughes-Austin JM, Katz R, Majka DS, Criqui MH, Robinson WH, Firestein GS, Hundley WG, Ix JH. PMID: 37874814; PMCID: PMC10597499.

View in: PubMed Mentions: Fields:
Med Medicine (General)Sci Science
A Simple and Versatile Test for Elbow Posterolateral Rotatory Instability. Hand (N Y). 2025 Jan; 20(1):37-42. Goldin AN, Dwight KD, Hentzen ER, Leek BT, Hughes-Austin JM, Ward SR, Abrams RA. PMID: 37489098; PMCID: PMC11653289.

View in: PubMed Mentions: 2 Fields:
Gen General Surgery Ort Orthopedics
Translation:Humans
The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts. ACR Open Rheumatol. 2023 Mar; 5(3):115-123. Cheng KY, Strotmeyer ES, Kado DM, Schousboe JT, Schenk S, Nevitt M, Lane NE, Hughes-Austin JM. PMID: 36694301; PMCID: PMC10010487.

View in: PubMed Mentions: 4
Musculoskeletal injuries sustained at the California, USA: Baja California, Mexico border. Inj Epidemiol. 2022 Aug 25; 9(1):27. Dwight KD, Kent WT, Hughes-Austin JM. PMID: 36008848; PMCID: PMC9403971.

View in: PubMed Mentions: 1
Density and Fat Fraction of the Psoas, Paraspinal, and Oblique Muscle Groups Are Associated With Lumbar Vertebral Bone Mineral Density in a Multi-Ethnic Community-Living Population: The Multi-Ethnic Study of Atherosclerosis. J Bone Miner Res. 2022 08; 37(8):1537-1544. Gurusamy P, Larsen BA, Allen RT, Ward SR, Allison MA, Hughes-Austin JM. PMID: 35690917; PMCID: PMC9682975.

View in: PubMed Mentions: 1 Fields:
Met Metabolism Ort Orthopedics
Prevalence of radiographic hip dysplasia in Japanese population-based study. Mod Rheumatol. 2022 Feb 28; 32(2):438-443. Cheng VK, Hasegawa M, Hattori T, Ito N, Linn E, Cheng K, Hughes-Austin J, Masuda K, Sudo A. PMID: 33910453.

View in: PubMed Mentions: 1 Fields:
Rhe Rheumatology
Translation:Humans
Evaluating associations of joint swelling, joint stiffness and joint pain with physical activity in first-degree relatives of patients with rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA), a prospective cohort study. BMJ Open. 2021 09 14; 11(9):e050883. Hughes-Austin JM, Ix JH, Ward SR, Weisman MH, ODell JR, Mikuls TR, Buckner JH, Gregersen PK, Keating RM, Demoruelle MK, Deane KD, Holers VM, Norris JM. PMID: 34521672; PMCID: PMC8442039.

View in: PubMed Mentions: 2 Fields:
Med Medicine (General)
Translation:Humans
The Vitamin D Metabolite Ratio Is Associated With Changes in Bone Density and Fracture Risk in Older Adults. J Bone Miner Res. 2021 12; 36(12):2343-2350. Ginsberg C, Hoofnagle AN, Katz R, Hughes-Austin J, Miller LM, Becker JO, Kritchevsky SB, Shlipak MG, Sarnak MJ, Ix JH. PMID: 34423858; PMCID: PMC8688212.

View in: PubMed Mentions: 17 Fields:
Met Metabolism Ort Orthopedics
Translation:Humans
Surgical site peptidylarginine deaminase 4 (PAD4), a biomarker of NETosis, correlates with insulin resistance in total joint arthroplasty patients: A preliminary report. PLoS One. 2021; 16(1):e0245594. Martins VF, Dobson CR, Begur M, Parekh J, Ball ST, Gonzalez F, Hughes-Austin JM, Schenk S. PMID: 33481860; PMCID: PMC7822240.

View in: PubMed Mentions: 3 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Regional variation in bone turnover at the iliac crest versus the greater trochanter. Bone. 2021 02; 143:115604. Hughes-Austin JM, Dwight KD, Ginsberg C, Tipps A, Salusky IB, Pereira RC, Ix JH. PMID: 32827849; PMCID: PMC7769907.

View in: PubMed Mentions: 1 Fields:
Met Metabolism Ort Orthopedics
Translation:Humans Cells
Metabolic Syndrome Is Associated With Higher Risk of Wound Complications After Total Hip Arthroplasty. Arthroplast Today. 2020 Sep; 6(3):571-577. Cheng KY, Ball ST, Gonzales FB, Schenk S, Hughes-Austin JM. PMID: 32802927; PMCID: PMC7419251.

View in: PubMed Mentions: 4
Biomarkers of Bone Turnover Identify Subsets of Chronic Kidney Disease Patients at Higher Risk for Fracture. J Clin Endocrinol Metab. 2020 08 01; 105(8). Hughes-Austin JM, Katz R, Semba RD, Kritchevsky SB, Bauer DC, Sarnak MJ, Ginsberg C, Shlipak MG, Lima F, Malluche HH, Ix JH. PMID: 32474604; PMCID: PMC7340189.

View in: PubMed Mentions: 8 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Plasma adiponectin levels are associated with circulating inflammatory cytokines in autoantibody positive first-degree relatives of rheumatoid arthritis patients. PLoS One. 2018; 13(6):e0199578. Hughes-Austin JM, Deane KD, Giles JT, Derber LA, Zerbe GO, Dabelea DM, Sokolove J, Robinson WH, Holers VM, Norris JM. PMID: 29940013; PMCID: PMC6016921.

View in: PubMed Mentions: 4 Fields:
Med Medicine (General)Sci Science
Translation:Humans
Lumbar Muscle Structure Predicts Operational Postures in Active-Duty Marines. J Orthop Sports Phys Ther. 2018 08; 48(8):613-621. Berry DB, Shahidi B, Rodríguez-Soto AE, Hughes-Austin JM, Kelly KR, Ward SR. PMID: 29772956.

View in: PubMed Mentions: 8 Fields:
Ort Orthopedics Phy Physical and Rehabilitation Me Spo Sports Medicine
Translation:Humans Cells
Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis. Am J Nephrol. 2017; 46(6):481-487. Hughes-Austin JM, Gan RW, Deane KD, Weisman MH, Demoruelle MK, Sokolove J, Robinson WH, Holers VM, Norris JM, Ix JH. PMID: 29237149; PMCID: PMC5788181.

View in: PubMed Mentions: 2 Fields:
Nep Nephrology
Translation:Humans
Association of cardiovascular disease risk factors with coronary artery calcium volume versus density. Heart. 2018 01; 104(2):135-143. Thomas IC, Shiau B, Denenberg JO, McClelland RL, Greenland P, de Boer IH, Kestenbaum BR, Lin GM, Daniels M, Forbang NI, Rifkin DE, Hughes-Austin J, Allison MA, Jeffrey Carr J, Ix JH, Criqui MH. PMID: 28814488; PMCID: PMC6004322.

View in: PubMed Mentions: 16 Fields:
Car Cardiology
Urinary Markers of Fibrosis and Risk of Cardiovascular Events and Death in Kidney Transplant Recipients: The FAVORIT Trial. Am J Transplant. 2017 Oct; 17(10):2640-2649. Park M, Katz R, Shlipak MG, Weiner D, Tracy R, Jotwani V, Hughes-Austin J, Gabbai F, Hsu CY, Pfeffer M, Bansal N, Bostom A, Gutierrez O, Sarnak M, Levey A, Ix JH. PMID: 28371433; PMCID: PMC5620109.

View in: PubMed Mentions: 19 Fields:
Tra Transplantation
Translation:Humans
Contribution of Lumbar Spine Pathology and Age to Paraspinal Muscle Size and Fatty Infiltration. Spine (Phila Pa 1976). 2017 Apr 15; 42(8):616-623. Shahidi B, Parra CL, Berry DB, Hubbard JC, Gombatto S, Zlomislic V, Allen RT, Hughes-Austin J, Garfin S, Ward SR. PMID: 27517512; PMCID: PMC5303569.

View in: PubMed Mentions: 85 Fields:
Ort Orthopedics
Translation:Humans
The Relation of Serum Potassium Concentration with Cardiovascular Events and Mortality in Community-Living Individuals. Clin J Am Soc Nephrol. 2017 02 07; 12(2):245-252. Hughes-Austin JM, Rifkin DE, Beben T, Katz R, Sarnak MJ, Deo R, Hoofnagle AN, Homma S, Siscovick DS, Sotoodehnia N, Psaty BM, de Boer IH, Kestenbaum B, Shlipak MG, Ix JH. PMID: 28143865; PMCID: PMC5293337.

View in: PubMed Mentions: 34 Fields:
Nep Nephrology
Urine Fibrosis Markers and Risk of Allograft Failure in Kidney Transplant Recipients: A Case-Cohort Ancillary Study of the FAVORIT Trial. Am J Kidney Dis. 2017 Mar; 69(3):410-419. Ix JH, Katz R, Bansal N, Foster M, Weiner DE, Tracy R, Jotwani V, Hughes-Austin J, McKay D, Gabbai F, Hsu CY, Bostom A, Levey AS, Shlipak MG. PMID: 28024930; PMCID: PMC7321838.

View in: PubMed Mentions: 30 Fields:
Nep Nephrology
Translation:Humans
Associations between cystatin C-based eGFR, ambulatory blood pressure parameters, and in-clinic versus ambulatory blood pressure agreement in older community-living adults. Blood Press Monit. 2016 Apr; 21(2):87-94. Woodell TB, Hughes-Austin JM, Tran TV, Malhotra A, Abdelmalek JA, Rifkin DE. PMID: 26683379; PMCID: PMC4783213.

View in: PubMed Mentions: 1 Fields:
Vas Vascular Diseases
Translation:Humans
Relationship of Coronary Calcium on Standard Chest CT Scans With Mortality. JACC Cardiovasc Imaging. 2016 Feb; 9(2):152-9. Hughes-Austin JM, Dominguez A, Allison MA, Wassel CL, Rifkin DE, Morgan CG, Daniels MR, Ikram U, Knox JB, Wright CM, Criqui MH, Ix JH. PMID: 26777213; PMCID: PMC4744104.

View in: PubMed Mentions: 37 Fields:
Car Cardiology Dia Diagnostic Imaging Vas Vascular Diseases
Translation:Humans
Urine Collagen Fragments and CKD Progression-The Cardiovascular Health Study. J Am Soc Nephrol. 2015 Oct; 26(10):2494-503. Ix JH, Biggs ML, Mukamal K, Djousse L, Siscovick D, Tracy R, Katz R, Delaney JA, Chaves P, Rifkin DE, Hughes-Austin JM, Garimella PS, Sarnak MJ, Shlipak MG, Kizer JR. PMID: 25655067; PMCID: PMC4587692.

View in: PubMed Mentions: 22 Fields:
Nep Nephrology
Leptin and incident cardiovascular disease: the Multi-ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2015 Mar; 239(1):67-72. Martin SS, Blaha MJ, Muse ED, Qasim AN, Reilly MP, Blumenthal RS, Nasir K, Criqui MH, McClelland RL, Hughes-Austin JM, Allison MA. PMID: 25574859; PMCID: PMC4331218.

View in: PubMed Mentions: 35 Fields:
Vas Vascular Diseases
Peripheral artery disease and non-coronary atherosclerosis in Hispanics: another paradox? Prog Cardiovasc Dis. 2014 Nov-Dec; 57(3):237-43. Forbang NI, Hughes-Austin JM, Allison MA, Criqui MH. PMID: 25443822; PMCID: PMC4254403.

View in: PubMed Mentions: 6 Fields:
Car Cardiology Vas Vascular Diseases
The relationship between adiposity-associated inflammation and coronary artery and abdominal aortic calcium differs by strata of central adiposity: The Multi-Ethnic Study of Atherosclerosis (MESA). Vasc Med. 2014 Aug; 19(4):264-271. Hughes-Austin JM, Wassel CL, Jiménez J, Criqui MH, Ix JH, Rasmussen-Torvik LJ, Budoff MJ, Jenny NS, Allison MA. PMID: 24907349; PMCID: PMC4258162.

View in: PubMed Mentions: 9 Fields:
Vas Vascular Diseases
Sleep Architecture and Mental Health Among Community-Dwelling Older Men. J Gerontol B Psychol Sci Soc Sci. 2015 Sep; 70(5):673-81. Smagula SF, Reynolds CF, Ancoli-Israel S, Barrett-Connor E, Dam TT, Hughes-Austin JM, Paudel M, Redline S, Stone KL, Cauley JA, Osteoporotic Fractures in Men (MrOS) Research Group. PMID: 24326077; PMCID: PMC4553710.

View in: PubMed Mentions: 19 Fields:
Ger Geriatrics Psy Psychology Soc Social Sciences
Translation:Humans
Performance of anti-cyclic citrullinated Peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease. Arthritis Rheum. 2013 Sep; 65(9):2243-52. Demoruelle MK, Parish MC, Derber LA, Kolfenbach JR, Hughes-Austin JM, Weisman MH, Gilliland W, Edison JD, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Norris JM, Holers VM, Deane KD. PMID: 23686569; PMCID: PMC3776020.

View in: PubMed Mentions: 36 Fields:
Rhe Rheumatology
Translation:Humans
Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis. Arthritis Rheum. 2013 Aug; 65(8):1995-2004. Young KA, Deane KD, Derber LA, Hughes-Austin JM, Wagner CA, Sokolove J, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, Norris JM. PMID: 23754702; PMCID: PMC3729718.

View in: PubMed Mentions: 25 Fields:
Rhe Rheumatology
Translation:Humans
Current Cardiovascular Risk Reports. Visceral adipose tissue and cardiovascular disease risk. 2013; 7(2):95-101. Hughes-austin JM, Larsen BA, Allison MA.
Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA). Ann Rheum Dis. 2013 Jun; 72(6):901-7. Hughes-Austin JM, Deane KD, Derber LA, Kolfenbach JR, Zerbe GO, Sokolove J, Lahey LJ, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, Norris JM. PMID: 22915618; PMCID: PMC3726193.

View in: PubMed Mentions: 55 Fields:
Rhe Rheumatology
Translation:Humans