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Linda Sorkin

TitleRecall Faculty
InstitutionUniversity of California San Diego
DepartmentAnesthesiology
Address9500 Gilman Drive #0818
La Jolla CA 92093
Phone619-543-3498
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    Collapse Research 
    Collapse Research Activities and Funding
    Spinal TNF elicits AMPAr trafficking and hyperalgesia
    NIH/NINDS R01NS067459May 1, 2010 - Apr 30, 2015
    Role: Principal Investigator
    The Regulatory Role of Spinal Lipoxins in Nociception
    NIH/NIDA R21DA021654May 1, 2007 - Apr 30, 2009
    Role: Principal Investigator
    Cytokine and MAP Kinase Involvement in Neuropathic Pain
    NIH/NINDS R01NS048563Jan 15, 2005 - Dec 31, 2009
    Role: Principal Investigator
    Annual Meeting of the American Pain Society
    NIH/NINDS U13NS043308Mar 5, 2002 - Aug 28, 2006
    Role: Principal Investigator
    Ca permeable non-NMDAr: New spinal sensitization pathway
    NIH/NINDS R01NS041580Dec 15, 2001 - Nov 30, 2007
    Role: Principal Investigator
    ANTIBODY NOCICEPTOR SENSITIZATION &ALLOYDNIA
    NIH/NINDS R01NS035630Apr 1, 1997 - Jan 31, 2002
    Role: Principal Investigator
    SPINAL MEDIATORS OF ARTHRITIS INDUCED HYPERALGESIA
    NIH/NIAMS R01AR042235Dec 29, 1994 - Nov 30, 1997
    Role: Principal Investigator
    AWAKE CAT SPINAL CORD CELLS DRUG AND BEHAVORIAL EFFECTS
    NIH/NINDS F32NS007623Mar 25, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sorkin L, Eddinger KA, Woller SA, Yaksh TL. Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Semin Immunopathol. 2018 Feb 08. PMID: 29423889.
      View in: PubMed
    2. Sorkin L. Immunotherapy for neuroblastoma elicits a complement dependent whole body allodynia. Scand J Pain. 2017 Dec 29; 1(3):168. PMID: 29913968.
      View in: PubMed
    3. Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin L, Ramachandran R. Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. Eur J Neurosci. 2016 07; 44(1):1714-22. PMID: 27108664.
      View in: PubMed
    4. Lerman I, Hauger R, Sorkin L, Proudfoot J, Davis B, Huang A, Lam K, Simon B, Baker DG. Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial. Neuromodulation. 2016 Apr; 19(3):283-90. PMID: 26990318.
      View in: PubMed
    5. Pritchard RA, Falk L, Larsson M, Leinders M, Sorkin L. Different phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammation. Pain. 2016 Jan; 157(1):137-46. PMID: 26313408; PMCID: PMC4711388.
    6. Yaksh TL, Woller SA, Ramachandran R, Sorkin L. The search for novel analgesics: targets and mechanisms. F1000Prime Rep. 2015; 7:56. PMID: 26097729; PMCID: PMC4447049.
    7. Sorkin L. Modulation of peripheral inflammation by the spinal cord. Handb Exp Pharmacol. 2015; 227:191-206. PMID: 25846620.
      View in: PubMed
    8. Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin L. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain. Pain. 2014 Jun; 155(6):1150-60. PMID: 24631588; PMCID: PMC4128246.
    9. Terme M, Dorvillius M, Cochonneau D, Chaumette T, Xiao W, Diccianni MB, Barbet J, Yu AL, Paris F, Sorkin L, Birklé S. Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects as therapeutic ch14.18 antibody to GD2 without antibody induced allodynia. PLoS One. 2014; 9(2):e87210. PMID: 24520328; PMCID: PMC3919714.
    10. Yin HZ, Hsu CI, Yu S, Rao SD, Sorkin L, Weiss JH. TNF-a triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp Neurol. 2012 Dec; 238(2):93-102. PMID: 22921461; PMCID: PMC3498614.
    11. Choi JI, Koehrn FJ, Sorkin L. Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn. Mol Pain. 2012 Jan 13; 8:4. PMID: 22243518; PMCID: PMC3305429.
    12. Riggs PK, Vaida F, Rossi SS, Sorkin L, Gouaux B, Grant I, Ellis RJ. A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men. Brain Res. 2012 Jan 11; 1431:46-52. PMID: 22133305.
      View in: PubMed
    13. Zuo Z, Sorkin L. Molecular mechanism of cross-organ reflex sensitization: should I pay attention to it? Anesthesiology. 2011 Jan; 114(1):14-5. PMID: 21150576.
      View in: PubMed
    14. Choi JI, Svensson CI, Koehrn FJ, Bhuskute A, Sorkin L. Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior. Pain. 2010 May; 149(2):243-53. PMID: 20202754; PMCID: PMC2860679.
    15. Sorkin L, Otto M, Baldwin WM, Vail E, Gillies SD, Handgretinger R, Barfield RC, Ming Yu H, Yu AL. Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia. Pain. 2010 Apr; 149(1):135-42. PMID: 20171010; PMCID: PMC3755890.
    16. Sorkin L, Yaksh TL. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics. 2009 Oct; 6(4):609-19. PMID: 19789066.
      View in: PubMed
    17. Sorkin L, Svensson CI, Jones-Cordero TL, Hefferan MP, Campana WM. Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat. J Neurosci Res. 2009 Mar; 87(4):948-55. PMID: 18855936; PMCID: PMC2644733.
    18. Waldburger JM, Boyle DL, Edgar M, Sorkin L, Levine YA, Pavlov VA, Tracey K, Firestein GS. Spinal p38 MAP kinase regulates peripheral cholinergic outflow. Arthritis Rheum. 2008 Sep; 58(9):2919-21. PMID: 18759350; PMCID: PMC4533855.
    19. Nagakura Y, Jones TL, Malkmus SA, Sorkin L, Yaksh TL. The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain. 2008 Oct 31; 139(3):569-77. PMID: 18692315; PMCID: PMC3346272.
    20. Sorkin L, Doom CM, Maruyama KP, Nanigian DB. Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase. Eur J Pharmacol. 2008 Jun 10; 587(1-3):118-23. PMID: 18440503; PMCID: PMC2703817.
    21. Schäfers M, Sorkin L. Effect of cytokines on neuronal excitability. Neurosci Lett. 2008 Jun 06; 437(3):188-93. PMID: 18420346.
      View in: PubMed
    22. Jones TL, Lustig AC, Sorkin L. Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation. Anesth Analg. 2007 Dec; 105(6):1650-6, table of contents. PMID: 18042863.
      View in: PubMed
    23. Jones TL, Hefferan MP, Marsala M, Sorkin L. Low-speed subcellular fractionation method for determining noxious stimulus-evoked spinal neurokinin-1 receptor internalization. J Neurosci Methods. 2007 Mar 30; 161(1):23-31. PMID: 17083983.
      View in: PubMed
    24. Boyle DL, Jones TL, Hammaker D, Svensson CI, Rosengren S, Albani S, Sorkin L, Firestein GS. Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med. 2006 Sep; 3(9):e338. PMID: 16953659; PMCID: PMC1560929.
    25. Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin L. Covariance among age, spinal p38 MAP kinase activation and allodynia. J Pain. 2006 May; 7(5):337-45. PMID: 16632323.
      View in: PubMed
    26. Jones TL, Sorkin L. Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. Pain. 2005 Oct; 117(3):259-70. PMID: 16150547.
      View in: PubMed
    27. Lee DH, Chang L, Sorkin L, Chaplan SR. Hyperpolarization-activated, cation-nonselective, cyclic nucleotide-modulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spinal nerve ligated rats. J Pain. 2005 Jul; 6(7):417-24. PMID: 15993819.
      View in: PubMed
    28. Svensson CI, Schäfers M, Jones TL, Powell H, Sorkin L. Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38. Neurosci Lett. 2005 May 13; 379(3):209-13. PMID: 15843065.
      View in: PubMed
    29. Jones TL, Sorkin L. Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors mediate development, but not maintenance, of secondary allodynia evoked by first-degree burn in the rat. J Pharmacol Exp Ther. 2004 Jul; 310(1):223-9. PMID: 15007101.
      View in: PubMed
    30. Schäfers M, Marziniak M, Sorkin L, Yaksh TL, Sommer C. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol. 2004 Jan; 185(1):160-8. PMID: 14697327.
      View in: PubMed
    31. Sorkin L, Moore J, Boyle DL, Yang L, Firestein GS. Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers. Exp Neurol. 2003 Nov; 184(1):162-8. PMID: 14637089.
      View in: PubMed
    32. Pogatzki EM, Niemeier JS, Sorkin L, Brennan TJ. Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incision. Pain. 2003 Sep; 105(1-2):97-107. PMID: 14499425.
      View in: PubMed
    33. Schäfers M, Sorkin L, Sommer C. Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats. Pain. 2003 Aug; 104(3):579-88. PMID: 12927630.
      View in: PubMed
    34. Sorkin L, Maruyama K, Boyle DL, Yang L, Marsala M, Firestein GS. Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis. Neurosci Lett. 2003 Apr 10; 340(2):119-22. PMID: 12668251.
      View in: PubMed
    35. Schäfers M, Svensson CI, Sommer C, Sorkin L. Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci. 2003 Apr 01; 23(7):2517-21. PMID: 12684435.
      View in: PubMed
    36. Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin L. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci. 2003 Apr 01; 23(7):3028-38. PMID: 12684490.
      View in: PubMed
    37. Junger H, Moore AC, Sorkin L. Effects of full-thickness burns on nociceptor sensitization in anesthetized rats. Burns. 2002 Dec; 28(8):772-7. PMID: 12464476.
      View in: PubMed
    38. Boyle DL, Moore J, Yang L, Sorkin L, Firestein GS. Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3076-82. PMID: 12428252.
      View in: PubMed
    39. Sorkin L, Yu AL, Junger H, Doom CM. Antibody directed against GD(2) produces mechanical allodynia, but not thermal hyperalgesia when administered systemically or intrathecally despite its dependence on capsaicin sensitive afferents. Brain Res. 2002 Mar 15; 930(1-2):67-74. PMID: 11879797.
      View in: PubMed
    40. Sorkin L, Yaksh TL, Doom CM. Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists. Anesthesiology. 2001 Oct; 95(4):965-73. PMID: 11605940.
      View in: PubMed
    41. Sorkin L. Antibody activation and immune reactions: potential linkage to pain and neuropathy. Pain Med. 2000 Dec; 1(4):296-302. PMID: 15101875.
      View in: PubMed
    42. Sorkin L, Doom CM. Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat. J Peripher Nerv Syst. 2000 Jun; 5(2):96-100. PMID: 10905468.
      View in: PubMed
    43. Sorkin L, Puig S, Jones DL. Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists. Pain. 1998 Aug; 77(2):181-90. PMID: 9766836.
      View in: PubMed
    44. Sorkin L, Puig S. Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist. Pain. 1996 Dec; 68(2-3):283-92. PMID: 9121816.
      View in: PubMed
    45. Sorkin L, Moore JH. Evoked Release of Amino Acids and Prostanoids in Spinal Cords of Anesthetized Rats: Changes During Peripheral Inflammation and Hyperalgesia. Am J Ther. 1996 Apr; 3(4):268-275. PMID: 11862260.
      View in: PubMed
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