Linda Sorkin

Title(s)Recall Faculty, Anesthesiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Targeting lipid rafts for treatment of migraine
    NIH R41NS113705Sep 30, 2019 - Aug 31, 2021
    Role: Co-Principal Investigator
    Spinal TNF elicits AMPAr trafficking and hyperalgesia
    NIH R01NS067459May 1, 2010 - Apr 30, 2016
    Role: Principal Investigator
    The Regulatory Role of Spinal Lipoxins in Nociception
    NIH R21DA021654May 1, 2007 - Apr 30, 2009
    Role: Principal Investigator
    Cytokine and MAP Kinase Involvement in Neuropathic Pain
    NIH R01NS048563Jan 15, 2005 - Dec 31, 2009
    Role: Principal Investigator
    Annual Meeting of the American Pain Society
    NIH U13NS043308Mar 5, 2002 - Aug 28, 2006
    Role: Principal Investigator
    Ca permeable non-NMDAr: New spinal sensitization pathway
    NIH R01NS041580Dec 15, 2001 - Nov 30, 2007
    Role: Principal Investigator
    ANTIBODY NOCICEPTOR SENSITIZATION &ALLOYDNIA
    NIH R01NS035630Apr 1, 1997 - Jan 31, 2002
    Role: Principal Investigator
    SPINAL MEDIATORS OF ARTHRITIS INDUCED HYPERALGESIA
    NIH R01AR042235Dec 29, 1994 - Nov 30, 1997
    Role: Principal Investigator
    AWAKE CAT SPINAL CORD CELLS DRUG AND BEHAVORIAL EFFECTS
    NIH F32NS007623Mar 25, 1986
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO. PLoS One. 2020; 15(7):e0236115. Diccianni MB, Kempinska K, Gangoti JA, Yu AL, Sorkin LS. PMID: 32697811; PMCID: PMC7375533.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge. PLoS One. 2019; 14(2):e0201212. Lerman I, Davis B, Huang M, Huang C, Sorkin L, Proudfoot J, Zhong E, Kimball D, Rao R, Simon B, Spadoni A, Strigo I, Baker DG, Simmons AN. PMID: 30759089; PMCID: PMC6373934.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    3. Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Semin Immunopathol. 2018 May; 40(3):237-247. Sorkin LS, Eddinger KA, Woller SA, Yaksh TL. PMID: 29423889; PMCID: PMC7879713.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    4. Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. Eur J Neurosci. 2016 07; 44(1):1714-22. Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R. PMID: 27108664; PMCID: PMC4931962.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial. Neuromodulation. 2016 Apr; 19(3):283-90. Lerman I, Hauger R, Sorkin L, Proudfoot J, Davis B, Huang A, Lam K, Simon B, Baker DG. PMID: 26990318.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    6. Different phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammation. Pain. 2016 Jan; 157(1):137-146. Pritchard RA, Falk L, Larsson M, Leinders M, Sorkin LS. PMID: 26313408; PMCID: PMC4711388.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. The search for novel analgesics: targets and mechanisms. F1000Prime Rep. 2015; 7:56. Yaksh TL, Woller SA, Ramachandran R, Sorkin LS. PMID: 26097729; PMCID: PMC4447049.
      View in: PubMed   Mentions: 26  
    8. Modulation of peripheral inflammation by the spinal cord. Handb Exp Pharmacol. 2015; 227:191-206. Sorkin LS. PMID: 25846620.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain. Pain. 2014 Jun; 155(6):1150-1160. Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS. PMID: 24631588; PMCID: PMC4128246.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    10. Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects as therapeutic ch14.18 antibody to GD2 without antibody induced allodynia. PLoS One. 2014; 9(2):e87210. Terme M, Dorvillius M, Cochonneau D, Chaumette T, Xiao W, Diccianni MB, Barbet J, Yu AL, Paris F, Sorkin LS, Birklé S. PMID: 24520328; PMCID: PMC3919714.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    11. TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp Neurol. 2012 Dec; 238(2):93-102. Yin HZ, Hsu CI, Yu S, Rao SD, Sorkin LS, Weiss JH. PMID: 22921461; PMCID: PMC3498614.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    12. Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn. Mol Pain. 2012 Jan 13; 8:4. Choi JI, Koehrn FJ, Sorkin LS. PMID: 22243518; PMCID: PMC3305429.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    13. A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men. Brain Res. 2012 Jan 11; 1431:46-52. Riggs PK, Vaida F, Rossi SS, Sorkin LS, Gouaux B, Grant I, Ellis RJ. PMID: 22133305; PMCID: PMC6200580.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    14. Molecular mechanism of cross-organ reflex sensitization: should I pay attention to it? Anesthesiology. 2011 Jan; 114(1):14-5. Zuo Z, Sorkin LS. PMID: 21150576.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior. Pain. 2010 May; 149(2):243-253. Choi JI, Svensson CI, Koehrn FJ, Bhuskute A, Sorkin LS. PMID: 20202754; PMCID: PMC2860679.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    16. Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia. Pain. 2010 Apr; 149(1):135-142. Sorkin LS, Otto M, Baldwin WM, Vail E, Gillies SD, Handgretinger R, Barfield RC, Yu HM, Yu AL. PMID: 20171010; PMCID: PMC3755890.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    17. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics. 2009 Oct; 6(4):609-19. Sorkin LS, Yaksh TL. PMID: 19789066; PMCID: PMC5084283.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    18. Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat. J Neurosci Res. 2009 Mar; 87(4):948-55. Sorkin L, Svensson CI, Jones-Cordero TL, Hefferan MP, Campana WM. PMID: 18855936; PMCID: PMC2644733.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Spinal p38 MAP kinase regulates peripheral cholinergic outflow. Arthritis Rheum. 2008 Sep; 58(9):2919-21. Waldburger JM, Boyle DL, Edgar M, Sorkin LS, Levine YA, Pavlov VA, Tracey K, Firestein GS. PMID: 18759350; PMCID: PMC4533855.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain. 2008 Oct 31; 139(3):569-577. Nagakura Y, Jones TL, Malkmus SA, Sorkin L, Yaksh TL. PMID: 18692315; PMCID: PMC3346272.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    21. Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase. Eur J Pharmacol. 2008 Jun 10; 587(1-3):118-23. Sorkin LS, Doom CM, Maruyama KP, Nanigian DB. PMID: 18440503; PMCID: PMC2703817.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. Effect of cytokines on neuronal excitability. Neurosci Lett. 2008 Jun 06; 437(3):188-93. Schäfers M, Sorkin L. PMID: 18420346.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    23. Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation. Anesth Analg. 2007 Dec; 105(6):1650-6, table of contents. Jones TL, Lustig AC, Sorkin LS. PMID: 18042863.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    24. Low-speed subcellular fractionation method for determining noxious stimulus-evoked spinal neurokinin-1 receptor internalization. J Neurosci Methods. 2007 Mar 30; 161(1):23-31. Jones TL, Hefferan MP, Marsala M, Sorkin LS. PMID: 17083983.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    25. Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med. 2006 Sep; 3(9):e338. Boyle DL, Jones TL, Hammaker D, Svensson CI, Rosengren S, Albani S, Sorkin L, Firestein GS. PMID: 16953659; PMCID: PMC1560929.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    26. Covariance among age, spinal p38 MAP kinase activation and allodynia. J Pain. 2006 May; 7(5):337-45. Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. PMID: 16632323.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    27. Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. Pain. 2005 Oct; 117(3):259-270. Jones TL, Sorkin LS. PMID: 16150547.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    28. Hyperpolarization-activated, cation-nonselective, cyclic nucleotide-modulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spinal nerve ligated rats. J Pain. 2005 Jul; 6(7):417-24. Lee DH, Chang L, Sorkin LS, Chaplan SR. PMID: 15993819.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38. Neurosci Lett. 2005 May 13; 379(3):209-13. Svensson CI, Schäfers M, Jones TL, Powell H, Sorkin LS. PMID: 15843065.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    30. Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors mediate development, but not maintenance, of secondary allodynia evoked by first-degree burn in the rat. J Pharmacol Exp Ther. 2004 Jul; 310(1):223-9. Jones TL, Sorkin LS. PMID: 15007101.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    31. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol. 2004 Jan; 185(1):160-8. Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. PMID: 14697327.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    32. Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers. Exp Neurol. 2003 Nov; 184(1):162-8. Sorkin LS, Moore J, Boyle DL, Yang L, Firestein GS. PMID: 14637089.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incision. Pain. 2003 Sep; 105(1-2):97-107. Pogatzki EM, Niemeier JS, Sorkin LS, Brennan TJ. PMID: 14499425.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    34. Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats. Pain. 2003 Aug; 104(3):579-588. Schäfers M, Sorkin LS, Sommer C. PMID: 12927630.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    35. Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis. Neurosci Lett. 2003 Apr 10; 340(2):119-22. Sorkin LS, Maruyama K, Boyle DL, Yang L, Marsala M, Firestein GS. PMID: 12668251.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci. 2003 Apr 01; 23(7):2517-21. Schäfers M, Svensson CI, Sommer C, Sorkin LS. PMID: 12684435; PMCID: PMC6742090.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    37. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci. 2003 Apr 01; 23(7):3028-38. Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. PMID: 12684490; PMCID: PMC6742101.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    38. Effects of full-thickness burns on nociceptor sensitization in anesthetized rats. Burns. 2002 Dec; 28(8):772-7. Junger H, Moore AC, Sorkin LS. PMID: 12464476.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    39. Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3076-82. Boyle DL, Moore J, Yang L, Sorkin LS, Firestein GS. PMID: 12428252.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    40. Antibody directed against GD(2) produces mechanical allodynia, but not thermal hyperalgesia when administered systemically or intrathecally despite its dependence on capsaicin sensitive afferents. Brain Res. 2002 Mar 15; 930(1-2):67-74. Sorkin LS, Yu AL, Junger H, Doom CM. PMID: 11879797.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists. Anesthesiology. 2001 Oct; 95(4):965-73. Sorkin LS, Yaksh TL, Doom CM. PMID: 11605940.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    42. Antibody activation and immune reactions: potential linkage to pain and neuropathy. Pain Med. 2000 Dec; 1(4):296-302. Sorkin LS. PMID: 15101875.
      View in: PubMed   Mentions:    Fields:    
    43. Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat. J Peripher Nerv Syst. 2000 Jun; 5(2):96-100. Sorkin LS, Doom CM. PMID: 10905468.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    44. Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists. Pain. 1998 Aug; 77(2):181-190. Sorkin LS, Puig S, Jones DL. PMID: 9766836.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    45. Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist. Pain. 1996 Dec; 68(2-3):283-92. Sorkin LS, Puig S. PMID: 9121816.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    46. Evoked Release of Amino Acids and Prostanoids in Spinal Cords of Anesthetized Rats: Changes During Peripheral Inflammation and Hyperalgesia. Am J Ther. 1996 Apr; 3(4):268-275. Sorkin LS, Moore JH. PMID: 11862260.
      View in: PubMed   Mentions: 2     Fields:    
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