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Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO. PLoS One. 2020; 15(7):e0236115.
Diccianni MB, Kempinska K, Gangoti JA, Yu AL, Sorkin LS. PMID: 32697811; PMCID: PMC7375533.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge. PLoS One. 2019; 14(2):e0201212.
Lerman I, Davis B, Huang M, Huang C, Sorkin L, Proudfoot J, Zhong E, Kimball D, Rao R, Simon B, Spadoni A, Strigo I, Baker DG, Simmons AN. PMID: 30759089; PMCID: PMC6373934.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Semin Immunopathol. 2018 May; 40(3):237-247.
Sorkin LS, Eddinger KA, Woller SA, Yaksh TL. PMID: 29423889; PMCID: PMC7879713.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. Eur J Neurosci. 2016 07; 44(1):1714-22.
Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R. PMID: 27108664; PMCID: PMC4931962.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial. Neuromodulation. 2016 Apr; 19(3):283-90.
Lerman I, Hauger R, Sorkin L, Proudfoot J, Davis B, Huang A, Lam K, Simon B, Baker DG. PMID: 26990318.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Different phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammation. Pain. 2016 Jan; 157(1):137-146.
Pritchard RA, Falk L, Larsson M, Leinders M, Sorkin LS. PMID: 26313408; PMCID: PMC4711388.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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The search for novel analgesics: targets and mechanisms. F1000Prime Rep. 2015; 7:56.
Yaksh TL, Woller SA, Ramachandran R, Sorkin LS. PMID: 26097729; PMCID: PMC4447049.
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PubMed Mentions:
26
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Modulation of peripheral inflammation by the spinal cord. Handb Exp Pharmacol. 2015; 227:191-206.
Sorkin LS. PMID: 25846620.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain. Pain. 2014 Jun; 155(6):1150-1160.
Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS. PMID: 24631588; PMCID: PMC4128246.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects as therapeutic ch14.18 antibody to GD2 without antibody induced allodynia. PLoS One. 2014; 9(2):e87210.
Terme M, Dorvillius M, Cochonneau D, Chaumette T, Xiao W, Diccianni MB, Barbet J, Yu AL, Paris F, Sorkin LS, Birklé S. PMID: 24520328; PMCID: PMC3919714.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp Neurol. 2012 Dec; 238(2):93-102.
Yin HZ, Hsu CI, Yu S, Rao SD, Sorkin LS, Weiss JH. PMID: 22921461; PMCID: PMC3498614.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn. Mol Pain. 2012 Jan 13; 8:4.
Choi JI, Koehrn FJ, Sorkin LS. PMID: 22243518; PMCID: PMC3305429.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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PubMed Mentions:
24 Fields:
Translation:
HumansCTClinical Trials
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Molecular mechanism of cross-organ reflex sensitization: should I pay attention to it? Anesthesiology. 2011 Jan; 114(1):14-5.
Zuo Z, Sorkin LS. PMID: 21150576.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior. Pain. 2010 May; 149(2):243-253.
Choi JI, Svensson CI, Koehrn FJ, Bhuskute A, Sorkin LS. PMID: 20202754; PMCID: PMC2860679.
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PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
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Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia. Pain. 2010 Apr; 149(1):135-142.
Sorkin LS, Otto M, Baldwin WM, Vail E, Gillies SD, Handgretinger R, Barfield RC, Yu HM, Yu AL. PMID: 20171010; PMCID: PMC3755890.
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PubMed Mentions:
56 Fields:
Translation:
Animals
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Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics. 2009 Oct; 6(4):609-19.
Sorkin LS, Yaksh TL. PMID: 19789066; PMCID: PMC5084283.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
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Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat. J Neurosci Res. 2009 Mar; 87(4):948-55.
Sorkin L, Svensson CI, Jones-Cordero TL, Hefferan MP, Campana WM. PMID: 18855936; PMCID: PMC2644733.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Spinal p38 MAP kinase regulates peripheral cholinergic outflow. Arthritis Rheum. 2008 Sep; 58(9):2919-21.
Waldburger JM, Boyle DL, Edgar M, Sorkin LS, Levine YA, Pavlov VA, Tracey K, Firestein GS. PMID: 18759350; PMCID: PMC4533855.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain. 2008 Oct 31; 139(3):569-577.
Nagakura Y, Jones TL, Malkmus SA, Sorkin L, Yaksh TL. PMID: 18692315; PMCID: PMC3346272.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase. Eur J Pharmacol. 2008 Jun 10; 587(1-3):118-23.
Sorkin LS, Doom CM, Maruyama KP, Nanigian DB. PMID: 18440503; PMCID: PMC2703817.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Effect of cytokines on neuronal excitability. Neurosci Lett. 2008 Jun 06; 437(3):188-93.
Schäfers M, Sorkin L. PMID: 18420346.
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PubMed Mentions:
83 Fields:
Translation:
AnimalsCells
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Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation. Anesth Analg. 2007 Dec; 105(6):1650-6, table of contents.
Jones TL, Lustig AC, Sorkin LS. PMID: 18042863.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Low-speed subcellular fractionation method for determining noxious stimulus-evoked spinal neurokinin-1 receptor internalization. J Neurosci Methods. 2007 Mar 30; 161(1):23-31.
Jones TL, Hefferan MP, Marsala M, Sorkin LS. PMID: 17083983.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med. 2006 Sep; 3(9):e338.
Boyle DL, Jones TL, Hammaker D, Svensson CI, Rosengren S, Albani S, Sorkin L, Firestein GS. PMID: 16953659; PMCID: PMC1560929.
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PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Covariance among age, spinal p38 MAP kinase activation and allodynia. J Pain. 2006 May; 7(5):337-45.
Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. PMID: 16632323.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. Pain. 2005 Oct; 117(3):259-270.
Jones TL, Sorkin LS. PMID: 16150547.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Hyperpolarization-activated, cation-nonselective, cyclic nucleotide-modulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spinal nerve ligated rats. J Pain. 2005 Jul; 6(7):417-24.
Lee DH, Chang L, Sorkin LS, Chaplan SR. PMID: 15993819.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38. Neurosci Lett. 2005 May 13; 379(3):209-13.
Svensson CI, Schäfers M, Jones TL, Powell H, Sorkin LS. PMID: 15843065.
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PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
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Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors mediate development, but not maintenance, of secondary allodynia evoked by first-degree burn in the rat. J Pharmacol Exp Ther. 2004 Jul; 310(1):223-9.
Jones TL, Sorkin LS. PMID: 15007101.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol. 2004 Jan; 185(1):160-8.
Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. PMID: 14697327.
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PubMed Mentions:
27 Fields:
Translation:
Animals
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Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers. Exp Neurol. 2003 Nov; 184(1):162-8.
Sorkin LS, Moore J, Boyle DL, Yang L, Firestein GS. PMID: 14637089.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incision. Pain. 2003 Sep; 105(1-2):97-107.
Pogatzki EM, Niemeier JS, Sorkin LS, Brennan TJ. PMID: 14499425.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats. Pain. 2003 Aug; 104(3):579-588.
Schäfers M, Sorkin LS, Sommer C. PMID: 12927630.
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PubMed Mentions:
41 Fields:
Translation:
Animals
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Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis. Neurosci Lett. 2003 Apr 10; 340(2):119-22.
Sorkin LS, Maruyama K, Boyle DL, Yang L, Marsala M, Firestein GS. PMID: 12668251.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci. 2003 Apr 01; 23(7):2517-21.
Schäfers M, Svensson CI, Sommer C, Sorkin LS. PMID: 12684435; PMCID: PMC6742090.
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PubMed Mentions:
163 Fields:
Translation:
AnimalsCells
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Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci. 2003 Apr 01; 23(7):3028-38.
Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. PMID: 12684490; PMCID: PMC6742101.
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PubMed Mentions:
99 Fields:
Translation:
AnimalsCells
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Effects of full-thickness burns on nociceptor sensitization in anesthetized rats. Burns. 2002 Dec; 28(8):772-7.
Junger H, Moore AC, Sorkin LS. PMID: 12464476.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3076-82.
Boyle DL, Moore J, Yang L, Sorkin LS, Firestein GS. PMID: 12428252.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Antibody directed against GD(2) produces mechanical allodynia, but not thermal hyperalgesia when administered systemically or intrathecally despite its dependence on capsaicin sensitive afferents. Brain Res. 2002 Mar 15; 930(1-2):67-74.
Sorkin LS, Yu AL, Junger H, Doom CM. PMID: 11879797.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists. Anesthesiology. 2001 Oct; 95(4):965-73.
Sorkin LS, Yaksh TL, Doom CM. PMID: 11605940.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Antibody activation and immune reactions: potential linkage to pain and neuropathy. Pain Med. 2000 Dec; 1(4):296-302.
Sorkin LS. PMID: 15101875.
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PubMed Mentions: Fields:
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Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat. J Peripher Nerv Syst. 2000 Jun; 5(2):96-100.
Sorkin LS, Doom CM. PMID: 10905468.
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PubMed Mentions:
51 Fields:
Translation:
Animals
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Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists. Pain. 1998 Aug; 77(2):181-190.
Sorkin LS, Puig S, Jones DL. PMID: 9766836.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist. Pain. 1996 Dec; 68(2-3):283-92.
Sorkin LS, Puig S. PMID: 9121816.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Evoked Release of Amino Acids and Prostanoids in Spinal Cords of Anesthetized Rats: Changes During Peripheral Inflammation and Hyperalgesia. Am J Ther. 1996 Apr; 3(4):268-275.
Sorkin LS, Moore JH. PMID: 11862260.
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PubMed Mentions:
2 Fields: