Harry Bluestein

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    National Institute of Allergy and Infectious DiseasesFellowship, Immunology
    Harvard Medical School , Boston, MAFellowship, Pathology
    Albert Einstein College of Medicine, Yeshiva University, Bronx, NYMD

    Collapse Overview 
    Collapse Overview
    Research Interests

    The identification and characterization of cell membrane molecules that serve as targets of systemic lupus erythematosus antibodies and on the role of those antibodies in the pathogenesis of SLE, particularly the neuropsychiatric manifestations.

    Collapse Research 
    Collapse Research Activities and Funding
    NIH P60AR040770Aug 1, 1991 - Feb 28, 2002
    Role: Principal Investigator
    NIH R01AR030036Jul 1, 1981 - Mar 31, 1994
    Role: Principal Investigator
    NIH R01AM030036Jul 1, 1981 - Mar 31, 1987
    Role: Principal Investigator
    NIH R01AR025719Dec 1, 1979 - Nov 30, 1991
    Role: Principal Investigator
    NIH R01AM025719Dec 1, 1979 - Nov 30, 1985
    Role: Principal Investigator
    NIH T32AR007062Jul 1, 1975 - Sep 30, 1998
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Utility of the ultrasound examination of the hand and wrist joints in the management of established rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014 Feb; 66(2):236-44. Ceponis A, Onishi M, Bluestein HG, Kalunian K, Townsend J, Kavanaugh A. PMID: 23983173.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    2. Improving knowledge in palliative medicine with a required hospice rotation for third-year medical students. Acad Med. 2004 Aug; 79(8):777-82. Porter-Williamson K, von Gunten CF, Garman K, Herbst L, Bluestein HG, Evans W. PMID: 15277135.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    3. Reduction in circulating dsDNA antibody titer after administration of LJP 394. J Rheumatol. 1997 Feb; 24(2):314-8. Weisman MH, Bluestein HG, Berner CM, de Haan HA. PMID: 9034989.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    4. Neuropsychiatric disease in Sjögren's syndrome: anti-ribosomal P and anti-neuronal antibodies. Am J Med. 1993 Aug; 95(2):153-60. Spezialetti R, Bluestein HG, Peter JB, Alexander EL. PMID: 8356981.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    5. BEN, a novel surface molecule of the immunoglobulin superfamily on avian hemopoietic progenitor cells shared with neural cells. Exp Cell Res. 1992 Nov; 203(1):91-9. Corbel C, Cormier F, Pourquie O, Bluestein HG. PMID: 1426054.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    6. An antigen expressed by avian neuronal cells is also expressed by activated T lymphocytes. Cell Immunol. 1992 Apr 15; 141(1):99-110. Corbel C, Bluestein HG, Pourquie O, Vaigot P, Le Douarin NM. PMID: 1372844.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. Neuropsychologic deficits and antineuronal antibodies in pediatric systemic lupus erythematosus. Clin Exp Rheumatol. 1990 Jul-Aug; 8(4):417-24. Papero PH, Bluestein HG, White P, Lipnick RN. PMID: 2397630.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    8. Antigenic polymorphism of human very late activation protein-2 (platelet glycoprotein Ia-IIa). Platelet alloantigen Hca. J Clin Invest. 1989 Mar; 83(3):978-85. Woods VL, Pischel KD, Avery ED, Bluestein HG. PMID: 2646323.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Anatomic and genetic considerations in the pathogenesis of ankylosing spondylitis. J Rheumatol Suppl. 1988 Sep; 16:29-32. Bluestein HG. PMID: 3057208.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Generation of human cytomegalovirus-specific cytotoxic T-lymphocytes in a short-term culture. J Immunol Methods. 1988 May 25; 110(1):69-77. Laubscher A, Bluestein HG, Spector SA, Zvaifler NJ. PMID: 2836515.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Platelet glycoproteins Ia, Ic, and IIa are physicochemically indistinguishable from the very late activation antigens adhesion-related proteins of lymphocytes and other cell types. J Clin Invest. 1988 Feb; 81(2):505-13. Pischel KD, Bluestein HG, Woods VL. PMID: 3276732.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    12. Effects of tilomisole, indomethacin and levamisole on regulation of Epstein Barr virus-induced B cell proliferation by peripheral blood mononuclear cells from normal individuals and patients with rheumatoid arthritis. Agents Actions. 1987 Aug; 21(3-4):266-8. Gilman SC, Bluestein HG. PMID: 2825478.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Neuropsychiatric manifestations of systemic lupus erythematosus. N Engl J Med. 1987 Jul 30; 317(5):309-11. Bluestein HG. PMID: 3600721.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    14. Polymorphism of lymphocyte function-associated antigen-1 demonstrated by a lupus patient's alloantiserum. J Clin Invest. 1987 Jun; 79(6):1607-14. Pischel KD, Marlin SD, Springer TA, Woods VL, Bluestein HG. PMID: 2438304.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2. J Immunol. 1987 Jan 01; 138(1):226-33. Pischel KD, Hemler ME, Huang C, Bluestein HG, Woods VL. PMID: 3023488.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    16. Regulation of the growth of Epstein-Barr virus-infected B cells: temporal profile of the in vitro development of three distinct cytotoxic cells. Cell Immunol. 1986 Nov; 103(1):84-95. Konttinen YT, Bluestein HG, Zvaifler NJ. PMID: 3026657.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Very late activation antigens (VLA) are human leukocyte-neuronal crossreactive cell surface antigens. J Exp Med. 1986 Aug 01; 164(2):393-406. Pischel KD, Bluestein HG, Woods VL. PMID: 2425033.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. Vancomycin-induced vasculitis. South Med J. 1986 Mar; 79(3):382-3. Markman M, Lim HW, Bluestein HG. PMID: 2937155.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Immunopathogenesis of the neuropsychiatric manifestations of systemic lupus erythematosus. Springer Semin Immunopathol. 1986; 9(2-3):237-49. Bluestein HG, Pischel KD, Woods VL. PMID: 3027907.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. Deoxy-ATP accumulation in adenosine deaminase-inhibited human B and T lymphocytes. Adv Exp Med Biol. 1986; 195 Pt A:503-7. Gruber HE, Cohen AH, Firestein GS, Redelman D, Bluestein HG. PMID: 3487921.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Longitudinal analysis of the relationship between blood pressure and migration: the Tokelau Island Migrant Study. Am J Epidemiol. 1985 Aug; 122(2):291-301. Salmond CE, Joseph JG, Prior IA, Stanley DG, Wessen AF. PMID: 4123367.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    22. Regulation of the growth of Epstein-Barr virus-infected B cells. I. Growth regression by E rosetting cells from VCA-positive donors is a combined effect of autologous mixed leukocyte reaction and activation of T8+ memory cells. J Immunol. 1985 Apr; 134(4):2287-93. Konttinen YT, Bluestein HG, Zvaifler NJ. PMID: 2857749.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    23. The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of purine-nucleoside phosphorylase deficiency. Cell Immunol. 1984 Jul; 86(2):501-9. Albert D, Bluestein HG, Willis RC, Nette K, Seegmiller JE. PMID: 6428752.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of adenosine deaminase deficiency. Cell Immunol. 1984 Jul; 86(2):510-7. Albert D, Bluestein HG, Thompson L, Seegmiller JE. PMID: 6610485.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Deoxyadenosine (AdR) inhibition of newly activated lymphocytes: blockade at the G0-G1 interface. J Immunol. 1984 Apr; 132(4):2030-8. Redelman D, Bluestein HG, Cohen AH, Depper JM, Wormsley S. PMID: 6421932.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    26. Deoxyadenosine modulates human suppressor T cell function and B cell differentiation stimulated by Staphylococcus aureus protein A. J Immunol. 1984 Apr; 132(4):1761-6. Cohen AH, Bluestein HG, Redelman D. PMID: 6199411.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    27. DNA synthesis inhibitors block protein synthesis in the human lymphocyte. Int J Immunopharmacol. 1984; 6(2):147-53. Albert DA, Bluestein HG. PMID: 6203850.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    28. Epstein-Barr virus and rheumatoid arthritis. Surv Immunol Res. 1984; 3(1):70-7. Bluestein HG, Hasler F. PMID: 6326237.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. Panning separation for monoclonal antibody-specific T-cell subsets: effects of enzymes and metabolic inhibitors. Microbiol Immunol. 1984; 28(12):1373-84. Goto M, Bluestein HG, Zvaifler NJ. PMID: 6398396.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    30. Analysis of the defects responsible for the impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E. J Immunol. 1983 Aug; 131(2):768-72. Hasler F, Bluestein HG, Zvaifler NJ, Epstein LB. PMID: 6306107.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    31. Antibodies reactive with central nervous system antigens. Hum Pathol. 1983 May; 14(5):424-8. Bluestein HG, Zvaifler NJ. PMID: 6132871.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation. J Exp Med. 1983 Jan 01; 157(1):173-88. Hasler F, Bluestein HG, Zvaifler NJ, Epstein LB. PMID: 6294213.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    33. The pathogenesis of central nervous system manifestations of systemic lupus erythematosus. Arthritis Rheum. 1982 Jul; 25(7):862-6. Zvaifler NJ, Bluestein HG. PMID: 7104058.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    34. Antineuronal antibodies in systemic lupus erythematosus. Arthritis Rheum. 1982 Jul; 25(7):773-8. Bluestein HG, Woods VL. PMID: 7104053.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    35. Oropharyngeal Epstein-Barr virus excretion in rheumatoid arthritis. Arthritis Rheum. 1982 Apr; 25(4):427-31. Depper JM, Zvaifler NJ, Bluestein HG. PMID: 6280734.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    36. Impaired regulation of Epstein-Barr virus-induced lymphocyte proliferation in rheumatoid arthritis is due to a T cell defect. J Immunol. 1981 Nov; 127(5):1899-902. Depper JM, Bluestein HG, Zvaifler NJ. PMID: 6271870.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    37. Procainamide-lymphocyte reactions. A possible explanation for drug-induced autoimmunity. Arthritis Rheum. 1981 Aug; 24(8):1019-23. Bluestein HG, Redelman D, Zvaifler NJ. PMID: 6169349.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    38. Cerebrospinal fluid antibodies to neuronal cells: association with neuropsychiatric manifestations of systemic lupus erythematosus. Am J Med. 1981 Feb; 70(2):240-6. Bluestein HG, Williams GW, Steinberg AD. PMID: 7468611.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    39. Brain-reactive lymphocytotoxic antibody in the cerebrospinal fluid of patients with systemic lupus erythematosus: correlation with central nervous system involvement. Clin Immunol Immunopathol. 1981 Jan; 18(1):126-32. Williams GW, Bluestein HG, Steinberg AD. PMID: 7460395.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    40. Altered regulation of Epstein-Barr virus induced lymphoblast proliferation in rheumatoid arthritis lymphoid cells. Arthritis Rheum. 1980 Jun; 23(6):626-32. Bardwick PA, Bluestein HG, Zvaifler NJ, Depper JM, Seegmiller JE. PMID: 6248075.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    41. Altered deoxynucleoside triphosphate levels paralleling deoxyadenosine toxicity in adenosine deaminase inhibited human lymphocytes. Adv Exp Med Biol. 1980; 122A:427-31. Bluestein HG, Thompson LF, Albert DA, Seegmiller JE. PMID: 6968502.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    42. Lymphocyte alteration by procainamide: relation to drug-induced lupus erythematosus syndrome. Lancet. 1979 Oct 20; 2(8147):816-9. Bluestein HG, Zvaifler NJ, Weisman MH, Shapiro RF. PMID: 90917.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    43. Antibody-mediated suppression of antibody-dependent cytotoxic effector cell function. Clin Immunol Immunopathol. 1979 Jul; 13(3):277-86. Zvaifler NJ, Bluestein HG. PMID: 88291.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    44. Heterogeneous neurocytotoxic antibodies in systemic lupus erythematosus. Clin Exp Immunol. 1979 Feb; 35(2):210-7. Bluestein HG. PMID: 436335.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    45. Lymphocyte reactivity of antisera to cryoproteins in systemic lupus erythematosus. Clin Immunol Immunopathol. 1979 Jan; 12(1):52-61. Klippel JH, Bluestein HG, Zvaifler NJ. PMID: 570468.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    46. Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1978 Aug; 75(8):3965-9. Bluestein HG. PMID: 279013.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    47. Antigen recognition by primed T lymphocytes in vitro. I. Separation of recognitive and proliferative phases of antigen-induced T cell activation. J Immunol. 1978 Jul; 121(1):239-44. Greenberg PD, Bluestein HG. PMID: 307572.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    48. Neoantigen of the membrane attack complex of human complement: Occurrence on peripheral blood leukocytes from patients with systemic lupus erythematosus. Arthritis Rheum. 1978 Mar; 21(2):177-82. Curd JG, Sundsmo JS, Kolb WP, Bluestein HG, Müller-Eberhard HJ. PMID: 76471.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    49. Accumulation of deoxyribonucleotides as a possible mediator of immunosuppression in hereditary deficiency of adenosine deaminase. Trans Assoc Am Physicians. 1978; 91:394-402. Bluestein HG, Willis RC, Thompson LF, Matsumoto S, Seegmiller JE. PMID: 314193.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    50. Antibody-mediated suppression of bone marrow colony formation in vitro. J Cell Physiol. 1978 Jan; 94(1):47-56. Meyer-Hamme S, Bluestein HG. PMID: 304065.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    51. Lymphocytotoxic antibody activity in cryoprecipitates from serum of patients with SLE. Arthritis Rheum. 1976 Sep-Oct; 19(5):844-50. Zvaifler NJ, Bluestein HG. PMID: 1085625.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    52. Hypocomplementemia in procainamide-associated systemic lupus erythematosus. Ann Intern Med. 1976 Mar; 84(3):293. Utsinger PD, Zvaifler NJ, Bluestein HG. PMID: 1259265.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    53. Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus. J Clin Invest. 1976 Feb; 57(2):509-16. Bluestein HG, Zvaifler NJ. PMID: 56343.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    54. Alloantiserum-mediated supperssion of Ir gene controlled antigen-induced lymphocyte activation: effect on uridine and leucine incorporation. J Immunol. 1975 Nov; 115(5):1206-11. Greenberg PD, Bluestein HG. PMID: 1176772.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    55. Alloantiserum-mediated suppression of histocompatibility-linked IR gene controlled immune responses. I. Histocompatibility antigen requirement. J Immunol. 1974 Nov; 113(5):1410-6. Bluestein HG. PMID: 4417776.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCellsPHPublic Health
    56. Alloantiserum-mediated suppression of histocompatibility-linked Ir-gene-controlled immune responses. Suppressive effects of IgG fragments derived from alloantisera. J Exp Med. 1974 Aug 01; 140(2):481-93. Bluestein HG. PMID: 4846415.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    57. Development of primary M, G, and A anti-TNP plaque-forming cell responses in vitro. J Immunol. 1973 Jul; 111(1):130-6. Bluestein HG, Pierce CW. PMID: 4576584.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    58. Specific immune response genes of the guinea pig. V. Influence of the GA and GT immune response genes on the specificity of cellular and humoral immune responses to a terpolymer of L-glutamic acid, L-alanine, and L-tyrosine. J Exp Med. 1972 Jan; 135(1):98-109. Bluestein HG, Green I, Maurer PH, Benacerraf B. PMID: 5009706.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    59. Specific immune response genes of the guinea pig. 3. Linkage of the GA and GT immune response genes to histocompatibility genotypes in inbred guinea pigs. J Exp Med. 1971 Dec 01; 134(6):1529-37. Bluestein HG, Ellman L, Green I, Benacerraf B. PMID: 5126638.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    60. Histocompatibility specificity. J Exp Med. 1971 Dec 01; 134(6):1538-44. Bluestein HG, Green I, Benacerraf B. PMID: 5126639.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    61. Specific immune response genes of the guinea pig. II. Relationship between the poly-L-lysine gene and the genes controlling immune responsiveness to copolymers of L-glutamic acid and L-alanine and L-glutamic acid and L-tyrosine in random-bred Hartley guinea pigs. J Exp Med. 1971 Aug 01; 134(2):471-81. Bluestein HG, Green I, Benacerraf B. PMID: 5559611.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    62. Specific immune response genes of the guinea pig. I. Dominant genetic control of immune responsiveness to copolymers of L-glutamic acid and L-alanine and L-glutamic acid and L-tyrosine. J Exp Med. 1971 Aug 01; 134(2):458-70. Bluestein HG, Green I, Benacerraf B. PMID: 5559610.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsPHPublic Health
    63. Anti-TNP antibody responses in vitro: augmented primary responses of carrier-primed spleen cells. J Immunol. 1971 Jan; 106(1):271-3. Katz DH, Bluestein HG, Rouques RJ, Pierce CW. PMID: 5101180.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    64. Croton oil induced suppression of the immune response of guinea-pigs. Nature. 1970 Nov 28; 228(5274):871-2. Bluestein HG, Green I. PMID: 5477020.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    65. The inability of RNA from lymph node cells from immunized strain 2 animals to confer immune competence to strain 13 lymph node cells in the DNP-PLL immune system. . 1970 Oct; 135(1):146-50. Bluestein HG, Green I, Benacerraf B. PMID: 5529148.
      View in: PubMed   Mentions:
    66. Seryl transfer ribonucleic acid synthetase from bakers' yeast. 3. The seryladenylate-enzyme complex and its interaction with transfer ribonucleic acids. J Biol Chem. 1968 Sep 25; 243(18):4693-9. Bluestein HG, Allende CC, Allende JE, Cantoni GL. PMID: 4879089.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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