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Sanford Shattil

TitleDistinguished Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Phone858-822-6425
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    Collapse Overview 
    Collapse Overview
    Research Interests
    Signaling Through Integrin Adhesion Receptors in Development, Vascular Biology and Cancer.

    Integrins represent a ubiquitous family of transmembrane adhesion receptors that transfer biological information between the extracellular and intracellular environments. The general term “integrin signaling” is often used to refer to this process, which is involved in regulating biological events as diverse as embryonic development, synaptic plasticity of the nervous system, innate and adaptive immunity, and the functions of circulating blood cells. Integrin signaling encompasses both “inside-out” signals that regulate integrin affinity and avidity for extracellular ligands and “outside-in” signals that regulate anchorage-dependent cellular responses, such as cell motility and changes in gene expression. Defects in integrin signaling promote certain vascular, inflammatory and neoplastic disorders. The focus of this laboratory is to unravel the molecular basis of integrin signaling as it pertains to development, vascular biology and cancer. In this context, integrin signaling is required for the proliferation and differentiation of stem cells and hematopoietic progenitors into megakaryocytes, for platelet function in hemostasis and thrombosis, for endothelial cell participation in wound healing and angiogenesis, and for tumor progression. Recent work from this laboratory using complementary experimental systems, including human platelets, genetically-modified mice, zebrafish and animal models of neoplasia, indicates that integrin signaling is initiated by their interaction with specific protein kinases, phosphatases and molecular adapters. A current challenge is to integrate the wealth of information obtained from basic research into a complete understanding of integrin signaling, with diagnostic and therapeutic implications for cardiovascular and neoplastic diseases.

    Education and Training
    BA - Psychology, University of Illinois - 1961-1964
    MD - University of Illinois College of Medicine - 1964-1968
    Intern/Resident - Boston City Hospital (Harvard) - 1968-1970
    Fellow - Hematology, Boston City Hospital, Thorndike Lab, Harvard - 1970-1971


    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Outside-In Integrin Signaling in Platelets
    NIH/NHLBI R01HL087939Apr 1, 2007 - Jan 31, 2008
    Role: Principal Investigator
    Cell Adhesion Mechanisms in Vascular Disease & Thrombosis
    NIH/NHLBI P01HL078784Dec 1, 2004 - Apr 30, 2020
    Role: Co-Investigator
    TRANSCRIPTION FACTOR NF-E2 IN ALPHA IIB BETA 3 SIGNALING
    NIH/NHLBI R01HL065198Aug 1, 2000 - Jul 31, 2006
    Role: Principal Investigator
    Integrin Signaling in Hemostasis and Blood Diseases
    NIH/NHLBI P01HL057900Apr 1, 1997 - Jan 31, 2014
    Role: Principal Investigator
    Discoveries at the Crossroads of Integrin and Inflammatory Signaling in Platelets
    NIH/NHLBI R01HL056595Jul 1, 1996 - May 31, 2021
    Role: Principal Investigator
    PLATELET SUFACE ACTIVATION IN HEMOSTASIS AND THROMBOSIS
    NIH/NHLBI R01HL049845Apr 1, 1993 - Mar 31, 1994
    Role: Principal Investigator
    CELL ADHESION MECHANISMS IN VASCULAR DISEASE
    NIH/NHLBI P01HL048728Sep 30, 1992 - Aug 31, 2004
    Role: Co-Investigator
    Regulation of Platelet and Endothelial Cell Function
    NIH P01HL040387Apr 1, 1988 - Apr 30, 2019
    Role: Co-Investigator
    MECHANISMS OF SIGNAL TRANSDUCTION IN HUMAN PLATELETS
    NIH/NHLBI R01HL026523Dec 1, 1980 - Nov 30, 1988
    Role: Principal Investigator
    Hematology Clinical Research Training Program
    NIH/NHLBI T32HL007439Jul 1, 1979 - Jun 30, 2019
    Role: Principal Investigator
    GENERAL CLINICAL RESEARCH CENTER
    NIH M01RR000833Dec 1, 1977 - Sep 30, 2005
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Liao Z, Kasirer-Friede A, Shattil S. Optogenetic interrogation of integrin aVß3 function in endothelial cells. J Cell Sci. 2017 Oct 15; 130(20):3532-3541. PMID: 28864764.
      View in: PubMed
    2. Shattil S. Blood's 70th anniversary: musings of a Blood editor, 2003-2007. Blood. 2016 06 02; 127(22):2649-51. PMID: 27257172.
      View in: PubMed
    3. Ley K, Rivera-Nieves J, Sandborn WJ, Shattil S. Integrin-based therapeutics: biological basis, clinical use and new drugs. Nat Rev Drug Discov. 2016 Mar; 15(3):173-83. PMID: 26822833; PMCID: PMC4890615.
    4. Streiff MB, Holmstrom B, Ashrani A, Bockenstedt PL, Chesney C, Eby C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Hendrie P, Kuderer N, Lee A, Lee JT, Lovrincevic M, Millenson MM, Neff AT, Ortel TL, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Yee GC, Zakarija A, McMillian N, Engh AM. Cancer-Associated Venous Thromboembolic Disease, Version 1.2015. J Natl Compr Canc Netw. 2015 Sep; 13(9):1079-95. PMID: 26358792.
      View in: PubMed
    5. Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg MH, Shattil S. Interaction of kindlin-2 with integrin ß3 promotes outside-in signaling responses by the aVß3 vitronectin receptor. Blood. 2015 Mar 19; 125(12):1995-2004. PMID: 25587038; PMCID: PMC4366628.
    6. Desgrosellier JS, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil S, Cheresh DA. Integrin avß3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell. 2014 Aug 11; 30(3):295-308. PMID: 25117682; PMCID: PMC4147869.
    7. van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil S, Schlievert PM, Choudhury B, Nizet V. The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design. Cell Host Microbe. 2014 Jun 11; 15(6):729-740. PMID: 24922575; PMCID: PMC4078075.
    8. Fitzpatrick P, Shattil S, Ablooglu AJ. C-terminal COOH of integrin ß1 is necessary for ß1 association with the kindlin-2 adapter protein. J Biol Chem. 2014 Apr 18; 289(16):11183-93. PMID: 24599960; PMCID: PMC4036257.
    9. Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil S. ADAP interactions with talin and kindlin promote platelet integrin aIIbß3 activation and stable fibrinogen binding. Blood. 2014 May 15; 123(20):3156-65. PMID: 24523237.
      View in: PubMed
    10. Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil S, Ruppert R, Moser M, Fässler R, Ginsberg MH. The mechanism of kindlin-mediated activation of integrin aIIbß3. Curr Biol. 2013 Nov 18; 23(22):2288-95. PMID: 24210614; PMCID: PMC3912999.
    11. Zhao H, Shattil S. Cutaneous thrombosis in PNH. Blood. 2013 Nov 07; 122(19):3249. PMID: 24354009.
      View in: PubMed
    12. Casar B, Rimann I, Kato H, Shattil S, Quigley JP, Deryugina EI. In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated ß1 integrin and induction of FAK/PI3K/Akt motility signaling. Oncogene. 2014 Jan 09; 33(2):255-68. PMID: 23208492; PMCID: PMC3931462.
    13. Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil S. The primacy of ß1 integrin activation in the metastatic cascade. PLoS One. 2012; 7(10):e46576. PMID: 23056350; PMCID: PMC3463578.
    14. Kahner BN, Kato H, Banno A, Ginsberg MH, Shattil S, Ye F. Kindlins, integrin activation and the regulation of talin recruitment to aIIbß3. PLoS One. 2012; 7(3):e34056. PMID: 22457811; PMCID: PMC3311585.
    15. Huang M, Anand S, Murphy EA, Desgrosellier JS, Stupack DG, Shattil S, Schlaepfer DD, Cheresh DA. EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene. 2012 May 31; 31(22):2783-93. PMID: 21963850; PMCID: PMC3711644.
    16. Qu H, Tu Y, Shi X, Larjava H, Saleem MA, Shattil S, Fukuda K, Qin J, Kretzler M, Wu C. Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci. 2011 Mar 15; 124(Pt 6):879-91. PMID: 21325030; PMCID: PMC3048888.
    17. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. PMID: 21177494; PMCID: PMC3093297.
    18. Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil S. What is vinculin needed for in platelets? J Thromb Haemost. 2010 Oct; 8(10):2294-304. PMID: 20670372; PMCID: PMC2965783.
    19. Ablooglu AJ, Tkachenko E, Kang J, Shattil S. Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development. 2010 Oct; 137(20):3449-58. PMID: 20843856; PMCID: PMC2947757.
    20. Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S, Klemke R. Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci. 2010 Jul 01; 123(Pt 13):2332-41. PMID: 20530574; PMCID: PMC2886748.
    21. Shattil S, Kim C, Ginsberg MH. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol. 2010 Apr; 11(4):288-300. PMID: 20308986; PMCID: PMC3929966.
    22. Kasirer-Friede A, Ruggeri ZM, Shattil S. Role for ADAP in shear flow-induced platelet mechanotransduction. Blood. 2010 Mar 18; 115(11):2274-82. PMID: 19996090; PMCID: PMC2844019.
    23. Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil S, Cheresh DA. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med. 2009 Oct; 15(10):1163-9. PMID: 19734908; PMCID: PMC2759406.
    24. Shattil S. The beta3 integrin cytoplasmic tail: protein scaffold and control freak. J Thromb Haemost. 2009 Jul; 7 Suppl 1:210-3. PMID: 19630802.
      View in: PubMed
    25. Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil S, Ginsberg MH. RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem. 2009 Feb 20; 284(8):5119-27. PMID: 19098287; PMCID: PMC2643525.
    26. Ablooglu AJ, Kang J, Petrich BG, Ginsberg MH, Shattil S. Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood. 2009 Apr 09; 113(15):3585-92. PMID: 19005179; PMCID: PMC2668853.
    27. Coller BS, Shattil S. The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood. 2008 Oct 15; 112(8):3011-25. PMID: 18840725; PMCID: PMC2569161.
    28. Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil S. Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets. Blood. 2009 Jan 08; 113(2):447-57. PMID: 18840708; PMCID: PMC2615656.
    29. Gutierrez E, Petrich BG, Shattil S, Ginsberg MH, Groisman A, Kasirer-Friede A. Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip. 2008 Sep; 8(9):1486-95. PMID: 18818803; PMCID: PMC2683765.
    30. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil S. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22. PMID: 18573917.
      View in: PubMed
    31. Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Féral CC, Ginsberg MH, Brower DL, Shattil S. Differences in regulation of Drosophila and vertebrate integrin affinity by talin. Mol Biol Cell. 2008 Aug; 19(8):3589-98. PMID: 18508915; PMCID: PMC2488300.
    32. Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil S, Kaushansky K. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood. 2008 Jan 15; 111(2):596-604. PMID: 17925492; PMCID: PMC2200856.
    33. Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil S, Ginsberg MH. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest. 2007 Aug; 117(8):2250-9. PMID: 17627302; PMCID: PMC1906732.
    34. Ablooglu AJ, Kang J, Handin RI, Traver D, Shattil S. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn. 2007 Aug; 236(8):2268-76. PMID: 17626277.
      View in: PubMed
    35. Kasirer-Friede A, Kahn ML, Shattil S. Platelet integrins and immunoreceptors. Immunol Rev. 2007 Aug; 218:247-64. PMID: 17624957.
      View in: PubMed
    36. Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil S, Ginsberg MH, Ross FP, Teitelbaum SL. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol. 2007 Mar 12; 176(6):877-88. PMID: 17353363; PMCID: PMC2064061.
    37. Prévost N, Kato H, Bodin L, Shattil S. Platelet integrin adhesive functions and signaling. Methods Enzymol. 2007; 426:103-15. PMID: 17697882.
      View in: PubMed
    38. Kaushansky K, Shattil S. Bloodlines: the importance of mentoring for the future of hematology. Blood. 2007 Feb 15; 109(4):1353-4. PMID: 17047145.
      View in: PubMed
    39. Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, Shattil S. ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists. Blood. 2007 Feb 01; 109(3):1018-25. PMID: 17003372; PMCID: PMC1785130.
    40. Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil S, Ginsberg MH. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol. 2006 Sep 19; 16(18):1796-806. PMID: 16979556.
      View in: PubMed
    41. Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil S, Kahn ML, Koretzky GA. Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol. 2006 Sep; 26(18):6936-49. PMID: 16943434; PMCID: PMC1592869.
    42. Orr AW, Ginsberg MH, Shattil S, Deckmyn H, Schwartz MA. Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell. 2006 Nov; 17(11):4686-97. PMID: 16928957; PMCID: PMC1635406.
    43. Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil S. A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost. 2006 Mar; 4(3):648-55. PMID: 16460447.
      View in: PubMed
    44. Gaur M, Kamata T, Wang S, Moran B, Shattil S, Leavitt AD. Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function. J Thromb Haemost. 2006 Feb; 4(2):436-42. PMID: 16420577.
      View in: PubMed
    45. Bunch TA, Helsten TL, Kendall TL, Shirahatti N, Mahadevan D, Shattil S, Brower DL. Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity. J Biol Chem. 2006 Feb 24; 281(8):5050-7. PMID: 16371365.
      View in: PubMed
    46. Ginsberg MH, Partridge A, Shattil S. Integrin regulation. Curr Opin Cell Biol. 2005 Oct; 17(5):509-16. PMID: 16099636.
      View in: PubMed
    47. Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil S. PTP-1B is an essential positive regulator of platelet integrin signaling. J Cell Biol. 2005 Aug 29; 170(5):837-45. PMID: 16115959; PMCID: PMC2171339.
    48. Shattil S. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 2005 Aug; 15(8):399-403. PMID: 16005629.
      View in: PubMed
    49. Arias-Salgado EG, Lizano S, Shattil S, Ginsberg MH. Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem. 2005 Aug 19; 280(33):29699-707. PMID: 15937333.
      View in: PubMed
    50. George JN, Shattil S. Letter to authors and readers regarding the new NIH policy on public access. Blood. 2005 May 15; 105(10):3767. PMID: 15817680.
      View in: PubMed
    51. Buensuceso CS, Obergfell A, Soriani A, Eto K, Kiosses WB, Arias-Salgado EG, Kawakami T, Shattil S. Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem. 2005 Jan 07; 280(1):644-53. PMID: 15536078.
      View in: PubMed
    52. Buensuceso CS, Arias-Salgado EG, Shattil S. Protein-protein interactions in platelet alphaIIbbeta3 signaling. Semin Thromb Hemost. 2004 Aug; 30(4):427-39. PMID: 15354264.
      View in: PubMed
    53. Shattil S, Newman PJ. Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood. 2004 Sep 15; 104(6):1606-15. PMID: 15205259.
      View in: PubMed
    54. de Virgilio M, Kiosses WB, Shattil S. Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells. J Cell Biol. 2004 May 10; 165(3):305-11. PMID: 15123737; PMCID: PMC2172182.
    55. Shattil S. Open access, yes! Open excess, no! Blood. 2004 May 01; 103(9):3257. PMID: 15096439.
      View in: PubMed
    56. Kerrigan SW, Gaur M, Murphy RP, Shattil S, Leavitt AD. Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation. Blood. 2004 Sep 01; 104(5):1327-34. PMID: 15059849.
      View in: PubMed
    57. Kasirer-Friede A, Cozzi MR, Mazzucato M, De Marco L, Ruggeri ZM, Shattil S. Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors. Blood. 2004 May 01; 103(9):3403-11. PMID: 14726383.
      View in: PubMed
    58. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil S. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13298-302. PMID: 14593208; PMCID: PMC263791.
    59. Tadokoro S, Shattil S, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA. Talin binding to integrin beta tails: a final common step in integrin activation. Science. 2003 Oct 03; 302(5642):103-6. PMID: 14526080.
      View in: PubMed
    60. Arya M, López JA, Romo GM, Cruz MA, Kasirer-Friede A, Shattil S, Anvari B. Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. J Thromb Haemost. 2003 Jun; 1(6):1150-7. PMID: 12871313.
      View in: PubMed
    61. Shattil S. A (blood) smear campaign. Blood. 2003 Apr 01; 101(7):2453. PMID: 12642341.
      View in: PubMed
    62. Buensuceso C, de Virgilio M, Shattil S. Detection of integrin alpha IIbbeta 3 clustering in living cells. J Biol Chem. 2003 Apr 25; 278(17):15217-24. PMID: 12595537.
      View in: PubMed
    63. Eto K, Leavitt AL, Nakano T, Shattil S. Development and analysis of megakaryocytes from murine embryonic stem cells. Methods Enzymol. 2003; 365:142-58. PMID: 14696343.
      View in: PubMed
    64. Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD, Shattil S. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12819-24. PMID: 12239348; PMCID: PMC130543.
    65. Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil S, Ginsberg MH. The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem. 2002 Oct 18; 277(42):39401-8. PMID: 12171941.
      View in: PubMed
    66. Wonerow P, Obergfell A, Wilde JI, Bobe R, Asazuma N, Brdicka T, Leo A, Schraven B, Horejsí V, Shattil S, Watson SP. Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets. Biochem J. 2002 Jun 15; 364(Pt 3):755-65. PMID: 12049640; PMCID: PMC1222625.
    67. Bertoni A, Tadokoro S, Eto K, Pampori N, Parise LV, White GC, Shattil S. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J Biol Chem. 2002 Jul 12; 277(28):25715-21. PMID: 11994301.
      View in: PubMed
    68. Baron W, Shattil S, ffrench-Constant C. The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. EMBO J. 2002 Apr 15; 21(8):1957-66. PMID: 11953315; PMCID: PMC125971.
    69. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil S. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002 Apr 15; 157(2):265-75. PMID: 11940607; PMCID: PMC2199242.
    70. Judd BA, Myung PS, Obergfell A, Myers EE, Cheng AM, Watson SP, Pear WS, Allman D, Shattil S, Koretzky GA. Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med. 2002 Mar 18; 195(6):705-17. PMID: 11901197.
      View in: PubMed
    71. Kasirer-Friede A, Ware J, Leng L, Marchese P, Ruggeri ZM, Shattil S. Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3. J Biol Chem. 2002 Apr 05; 277(14):11949-56. PMID: 11812775.
      View in: PubMed
    72. Woodside DG, Obergfell A, Leng L, Wilsbacher JL, Miranti CK, Brugge JS, Shattil S, Ginsberg MH. Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr Biol. 2001 Nov 13; 11(22):1799-804. PMID: 11719224.
      View in: PubMed
    73. Woodside DG, Shattil S, Ginsberg MH. The T cell receptor SLAPs integrins together. Nat Immunol. 2001 Oct; 2(10):904-5. PMID: 11577344.
      View in: PubMed
    74. Tzima E, del Pozo MA, Shattil S, Chien S, Schwartz MA. Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J. 2001 Sep 03; 20(17):4639-47. PMID: 11532928; PMCID: PMC125600.
    75. Derrick JM, Shattil S, Poncz M, Gruppo RA, Gartner TK. Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide. Thromb Haemost. 2001 Sep; 86(3):894-901. PMID: 11583324.
      View in: PubMed
    76. Shattil S, Leavitt AD. All in the family: primary megakaryocytes for studies of platelet alphaIIbbeta3 signaling. Thromb Haemost. 2001 Jul; 86(1):259-65. PMID: 11487014.
      View in: PubMed
    77. Kiosses WB, Shattil S, Pampori N, Schwartz MA. Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol. 2001 Mar; 3(3):316-20. PMID: 11231584.
      View in: PubMed
    78. Felding-Habermann B, O'Toole TE, Smith JW, Fransvea E, Ruggeri ZM, Ginsberg MH, Hughes PE, Pampori N, Shattil S, Saven A, Mueller BM. Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1853-8. PMID: 11172040; PMCID: PMC29346.
    79. Honda S, Tomiyama Y, Pampori N, Kashiwagi H, Kiyoi T, Kosugi S, Tadokoro S, Kurata Y, Shattil S, Matsuzawa Y. Ligand binding to integrin alpha(v)beta(3) requires tyrosine 178 in the alpha(v) subunit. Blood. 2001 Jan 01; 97(1):175-82. PMID: 11133758.
      View in: PubMed
    80. Obergfell A, Judd BA, del Pozo MA, Schwartz MA, Koretzky GA, Shattil S. The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. J Biol Chem. 2001 Feb 23; 276(8):5916-23. PMID: 11113155.
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    81. Judd BA, Myung PS, Leng L, Obergfell A, Pear WS, Shattil S, Koretzky GA. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12056-61. PMID: 11050236; PMCID: PMC17293.
    82. Byzova TV, Goldman CK, Pampori N, Thomas KA, Bett A, Shattil S, Plow EF. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol Cell. 2000 Oct; 6(4):851-60. PMID: 11090623.
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    83. Schwartz MA, Shattil S. Signaling networks linking integrins and rho family GTPases. Trends Biochem Sci. 2000 Aug; 25(8):388-91. PMID: 10916159.
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    84. Calderwood DA, Shattil S, Ginsberg MH. Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem. 2000 Jul 28; 275(30):22607-10. PMID: 10801899.
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    85. Shiraga M, Ritchie A, Aidoudi S, Baron V, Wilcox D, White G, Ybarrondo B, Murphy G, Leavitt A, Shattil S. Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. J Cell Biol. 1999 Dec 27; 147(7):1419-30. PMID: 10613901; PMCID: PMC2174239.
    86. Shattil S. Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways. Thromb Haemost. 1999 Aug; 82(2):318-25. PMID: 10605720.
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    87. Pampori N, Hato T, Stupack DG, Aidoudi S, Cheresh DA, Nemerow GR, Shattil S. Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem. 1999 Jul 30; 274(31):21609-16. PMID: 10419468.
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    88. Kashiwagi H, Tomiyama Y, Tadokoro S, Honda S, Shiraga M, Mizutani H, Handa M, Kurata Y, Matsuzawa Y, Shattil S. A mutation in the extracellular cysteine-rich repeat region of the beta3 subunit activates integrins alphaIIbbeta3 and alphaVbeta3. Blood. 1999 Apr 15; 93(8):2559-68. PMID: 10194435.
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    89. Law DA, Nannizzi-Alaimo L, Ministri K, Hughes PE, Forsyth J, Turner M, Shattil S, Ginsberg MH, Tybulewicz VL, Phillips DR. Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. Blood. 1999 Apr 15; 93(8):2645-52. PMID: 10194444.
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    90. Miranti CK, Leng L, Maschberger P, Brugge JS, Shattil S. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr Biol. 1998 Dec 03; 8(24):1289-99. PMID: 9843681.
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    91. Hato T, Pampori N, Shattil S. Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3. J Cell Biol. 1998 Jun 29; 141(7):1685-95. PMID: 9647659; PMCID: PMC2133003.
    92. Leng L, Kashiwagi H, Ren XD, Shattil S. RhoA and the function of platelet integrin alphaIIbbeta3. Blood. 1998 Jun 01; 91(11):4206-15. PMID: 9596668.
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    93. Shattil S, Kashiwagi H, Pampori N. Integrin signaling: the platelet paradigm. Blood. 1998 Apr 15; 91(8):2645-57. PMID: 9531572.
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    94. Shattil S, Ginsberg MH. Integrin signaling in vascular biology. J Clin Invest. 1997 Dec 01; 100(11 Suppl):S91-5. PMID: 9413409.
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    95. Gao J, Zoller KE, Ginsberg MH, Brugge JS, Shattil S. Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J. 1997 Nov 03; 16(21):6414-25. PMID: 9351824; PMCID: PMC1170248.
    96. Wang R, Shattil S, Ambruso DR, Newman PJ. Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. J Clin Invest. 1997 Nov 01; 100(9):2393-403. PMID: 9351872; PMCID: PMC508438.
    97. Phillips DR, Teng W, Arfsten A, Nannizzi-Alaimo L, White MM, Longhurst C, Shattil S, Randolph A, Jakubowski JA, Jennings LK, Scarborough RM. Effect of Ca2+ on GP IIb-IIIa interactions with integrilin: enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate. Circulation. 1997 Sep 02; 96(5):1488-94. PMID: 9315536.
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    98. Shattil S, Gao J, Kashiwagi H. Not just another pretty face: regulation of platelet function at the cytoplasmic face of integrin alpha IIb beta 3. Thromb Haemost. 1997 Jul; 78(1):220-5. PMID: 9198157.
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    99. Shattil S, Ginsberg MH. Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology. J Clin Invest. 1997 Jul 01; 100(1):1-5. PMID: 9202049; PMCID: PMC508157.
    100. Kashiwagi H, Schwartz MA, Eigenthaler M, Davis KA, Ginsberg MH, Shattil S. Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail. J Cell Biol. 1997 Jun 16; 137(6):1433-43. PMID: 9182673; PMCID: PMC2132534.
    101. Eigenthaler M, Höfferer L, Shattil S, Ginsberg MH. A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin. J Biol Chem. 1997 Mar 21; 272(12):7693-8. PMID: 9065427.
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    102. Baker EK, Tozer EC, Pfaff M, Shattil S, Loftus JC, Ginsberg MH. A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1973-8. PMID: 9050889; PMCID: PMC20027.
    103. Kunicki TJ, Annis DS, Deng YJ, Loftus JC, Shattil S. A molecular basis for affinity modulation of Fab ligand binding to integrin alphaIIb beta3. J Biol Chem. 1996 Aug 23; 271(34):20315-21. PMID: 8702765.
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    104. Basani RB, Vilaire G, Shattil S, Kolodziej MA, Bennett JS, Poncz M. Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3. Blood. 1996 Jul 01; 88(1):167-73. PMID: 8704171.
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    105. Hughes PE, Diaz-Gonzalez F, Leong L, Wu C, McDonald JA, Shattil S, Ginsberg MH. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem. 1996 Mar 22; 271(12):6571-4. PMID: 8636068.
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    106. Fox JE, Shattil S, Kinlough-Rathbone RL, Richardson M, Packham MA, Sanan DA. The platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin. J Biol Chem. 1996 Mar 22; 271(12):7004-11. PMID: 8636130.
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    107. Zhang J, Zhang J, Shattil S, Cunningham MC, Rittenhouse SE. Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbbeta3 integrin. J Biol Chem. 1996 Mar 15; 271(11):6265-72. PMID: 8626420.
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    108. Leong L, Hughes PE, Schwartz MA, Ginsberg MH, Shattil S. Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK. J Cell Sci. 1995 Dec; 108 ( Pt 12):3817-25. PMID: 8719888.
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    109. Shattil S, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH. Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol. 1995 Nov; 131(3):807-16. PMID: 7593198; PMCID: PMC2120613.
    110. Shattil S. Function and regulation of the beta 3 integrins in hemostasis and vascular biology. Thromb Haemost. 1995 Jul; 74(1):149-55. PMID: 8578448.
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    111. Hughes PE, O'Toole TE, Ylänne J, Shattil S, Ginsberg MH. The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J Biol Chem. 1995 May 26; 270(21):12411-7. PMID: 7759482.
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    112. Gao J, Shattil S. An enzyme-linked immunosorbent assay to identify inhibitors of activation of platelet integrin alpha IIb beta 3. J Immunol Methods. 1995 Apr 12; 181(1):55-64. PMID: 7537313.
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    113. Konstantopoulos K, Wu KK, Udden MM, Bañez EI, Shattil S, Hellums JD. Flow cytometric studies of platelet responses to shear stress in whole blood. Biorheology. 1995 Jan-Feb; 32(1):73-93. PMID: 7548862.
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    114. Clark EA, Shattil S, Ginsberg MH, Bolen J, Brugge JS. Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. J Biol Chem. 1994 Nov 18; 269(46):28859-64. PMID: 7961845.
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    115. Clark EA, Shattil S, Brugge JS. Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci. 1994 Nov; 19(11):464-9. PMID: 7855888.
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    116. Shattil S, Ginsberg MH, Brugge JS. Adhesive signaling in platelets. Curr Opin Cell Biol. 1994 Oct; 6(5):695-704. PMID: 7530462.
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    117. Abrams C, Deng YJ, Steiner B, O'Toole T, Shattil S. Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3. J Biol Chem. 1994 Jul 22; 269(29):18781-8. PMID: 7518445.
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    118. Chen YP, O'Toole TE, Shipley T, Forsyth J, LaFlamme SE, Yamada KM, Shattil S, Ginsberg MH. "Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains. J Biol Chem. 1994 Jul 15; 269(28):18307-10. PMID: 8034576.
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    119. McLane MA, Kowalska MA, Silver L, Shattil S, Niewiarowski S. Interaction of disintegrins with the alpha IIb beta 3 receptor on resting and activated human platelets. Biochem J. 1994 Jul 15; 301 ( Pt 2):429-36. PMID: 8042985; PMCID: PMC1137098.
    120. Shattil S, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS. Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem. 1994 May 20; 269(20):14738-45. PMID: 7514181.
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    121. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil S, Ginsberg MH. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol. 1994 Mar; 124(6):1047-59. PMID: 7510712; PMCID: PMC2119979.
    122. Prammer KV, Boyer J, Ugen K, Shattil S, Kieber-Emmons T. Bioactive Arg-Gly-Asp conformations in anti-integrin GPIIb-IIIa antibodies. Receptor. 1994; 4(2):93-108. PMID: 7524891.
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    123. Poncz M, Rifat S, Coller BS, Newman PJ, Shattil S, Parrella T, Fortina P, Bennett JS. Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. J Clin Invest. 1994 Jan; 93(1):172-9. PMID: 8282784; PMCID: PMC293750.
    124. Ugarova TP, Budzynski AZ, Shattil S, Ruggeri ZM, Ginsberg MH, Plow EF. Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIa. J Biol Chem. 1993 Oct 05; 268(28):21080-7. PMID: 7691805.
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    125. Haimovich B, Lipfert L, Brugge JS, Shattil S. Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem. 1993 Jul 25; 268(21):15868-77. PMID: 8340412.
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    126. Shattil S. Regulation of platelet anchorage and signaling by integrin alpha IIb beta 3. Thromb Haemost. 1993 Jul 01; 70(1):224-8. PMID: 7694387.
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    127. Huang MM, Lipfert L, Cunningham M, Brugge JS, Ginsberg MH, Shattil S. Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol. 1993 Jul; 122(2):473-83. PMID: 7686553; PMCID: PMC2119653.
    128. Shattil S, Cunningham M, Wiedmer T, Zhao J, Sims PJ, Brass LF. Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J Biol Chem. 1992 Sep 15; 267(26):18424-31. PMID: 1326524.
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    129. Tomiyama Y, Brojer E, Ruggeri ZM, Shattil S, Smiltneck J, Gorski J, Kumar A, Kieber-Emmons T, Kunicki TJ. A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3. J Biol Chem. 1992 Sep 05; 267(25):18085-92. PMID: 1517241.
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    130. Savage B, Shattil S, Ruggeri ZM. Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J Biol Chem. 1992 Jun 05; 267(16):11300-6. PMID: 1597464.
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    131. Abrams CS, Ruggeri ZM, Taub R, Hoxie JA, Nagaswami C, Weisel JW, Shattil S. Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen. J Biol Chem. 1992 Feb 05; 267(4):2775-85. PMID: 1370832.
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    132. Taichman NS, Iwase M, Lally ET, Shattil S, Cunningham ME, Korchak HM. Early changes in cytosolic calcium and membrane potential induced by Actinobacillus actinomycetemcomitans leukotoxin in susceptible and resistant target cells. J Immunol. 1991 Nov 15; 147(10):3587-94. PMID: 1940358.
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    133. O'Toole TE, Mandelman D, Forsyth J, Shattil S, Plow EF, Ginsberg MH. Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science. 1991 Nov 08; 254(5033):845-7. PMID: 1948065.
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    134. Shattil S, Brugge JS. Protein tyrosine phosphorylation and the adhesive functions of platelets. Curr Opin Cell Biol. 1991 Oct; 3(5):869-79. PMID: 1931088.
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    135. Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shattil S. Platelet-derived microparticles express high affinity receptors for factor VIII. J Biol Chem. 1991 Sep 15; 266(26):17261-8. PMID: 1654328.
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    136. Huang MM, Bolen JB, Barnwell JW, Shattil S, Brugge JS. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7844-8. PMID: 1715582; PMCID: PMC52400.
    137. Sims PJ, Ginsberg MH, Plow EF, Shattil S. Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J Biol Chem. 1991 Apr 25; 266(12):7345-52. PMID: 1902217.
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    138. Lages B, Shattil S, Bainton DF, Weiss HJ. Decreased content and surface expression of alpha-granule membrane protein GMP-140 in one of two types of platelet alpha delta storage pool deficiency. J Clin Invest. 1991 Mar; 87(3):919-29. PMID: 1705568; PMCID: PMC329883.
    139. George JN, Shattil S. The clinical importance of acquired abnormalities of platelet function. N Engl J Med. 1991 Jan 03; 324(1):27-39. PMID: 1984161.
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    140. Brass LF, Manning DR, Shattil S. GTP-binding proteins and platelet activation. Prog Hemost Thromb. 1991; 10:127-74. PMID: 1848944.
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    141. Golden A, Brugge JS, Shattil S. Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins. J Cell Biol. 1990 Dec; 111(6 Pt 2):3117-27. PMID: 1702789; PMCID: PMC2116418.
    142. Ginsberg MH, Frelinger AL, Lam SC, Forsyth J, McMillan R, Plow EF, Shattil S. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood. 1990 Nov 15; 76(10):2017-23. PMID: 2242424.
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    143. O'Toole TE, Loftus JC, Du XP, Glass AA, Ruggeri ZM, Shattil S, Plow EF, Ginsberg MH. Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul. 1990 Nov; 1(12):883-93. PMID: 2100193; PMCID: PMC362859.
    144. McCrae KR, Shattil S, Cines DB. Platelet activation induces increased Fc gamma receptor expression. J Immunol. 1990 May 15; 144(10):3920-7. PMID: 2139675.
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    145. Wiedmer T, Shattil S, Cunningham M, Sims PJ. Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor. Biochemistry. 1990 Jan 23; 29(3):623-32. PMID: 2159784.
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    146. Abrams CS, Ellison N, Budzynski AZ, Shattil S. Direct detection of activated platelets and platelet-derived microparticles in humans. Blood. 1990 Jan 01; 75(1):128-38. PMID: 2294986.
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    147. Shattil S, Budzynski A, Scrutton MC. Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists. Blood. 1989 Jan; 73(1):150-8. PMID: 2535942.
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    148. Bennett JS, Shattil S, Power JW, Gartner TK. Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex. J Biol Chem. 1988 Sep 15; 263(26):12948-53. PMID: 3417645.
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    149. Shattil S. Expression, regulation and detection of fibrinogen receptors on activated human platelets. Prog Clin Biol Res. 1988; 283:345-80. PMID: 3062628.
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    150. Shattil S, Cunningham M, Hoxie JA. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood. 1987 Jul; 70(1):307-15. PMID: 3297204.
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    151. Shattil S, Motulsky HJ, Insel PA, Flaherty L, Brass LF. Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine. Blood. 1986 Dec; 68(6):1224-31. PMID: 3779100.
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    152. Shattil S, Hoxie JA, Cunningham M, Brass LF. Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. J Biol Chem. 1985 Sep 15; 260(20):11107-14. PMID: 2411729.
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    153. Brass LF, Shattil S, Kunicki TJ, Bennett JS. Effect of calcium on the stability of the platelet membrane glycoprotein IIb-IIIa complex. J Biol Chem. 1985 Jul 05; 260(13):7875-81. PMID: 2409078.
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    154. Shattil S, Brass LF, Bennett JS, Pandhi P. Biochemical and functional consequences of dissociation of the platelet membrane glycoprotein IIb-IIIa complex. Blood. 1985 Jul; 66(1):92-8. PMID: 3159447.
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    155. Shattil S, Brass LF. The interaction of extracellular calcium with the platelet membrane glycoprotein IIb-IIIa complex. Nouv Rev Fr Hematol. 1985; 27(4):211-7. PMID: 2997701.
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    156. Brass LF, Shattil S. Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets. J Clin Invest. 1984 Mar; 73(3):626-32. PMID: 6231306; PMCID: PMC425061.
    157. Shattil S, Bennett JS, McDonough M, Turnbull J. Carbenicillin and penicillin G inhibit platelet function in vitro by impairing the interaction of agonists with the platelet surface. J Clin Invest. 1980 Feb; 65(2):329-37. PMID: 6243309; PMCID: PMC371371.
    158. Shattil S, Anaya-Galindo R, Bennett J, Colman RW, Cooper RA. Platelet hypersensitivity induced by cholesterol incorporation. J Clin Invest. 1975 Mar; 55(3):636-43. PMID: 1117069; PMCID: PMC301792.