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Sanford Shattil

Title(s)Distinguished Professor, Medicine
SchoolHealth Sciences
Phone858-822-6425
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    Collapse Overview 
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    Research Interests
    Signaling Through Integrin Adhesion Receptors in Development, Vascular Biology and Cancer.

    Integrins represent a ubiquitous family of transmembrane adhesion receptors that transfer biological information between the extracellular and intracellular environments. The general term “integrin signaling” is often used to refer to this process, which is involved in regulating biological events as diverse as embryonic development, synaptic plasticity of the nervous system, innate and adaptive immunity, and the functions of circulating blood cells. Integrin signaling encompasses both “inside-out” signals that regulate integrin affinity and avidity for extracellular ligands and “outside-in” signals that regulate anchorage-dependent cellular responses, such as cell motility and changes in gene expression. Defects in integrin signaling promote certain vascular, inflammatory and neoplastic disorders. The focus of this laboratory is to unravel the molecular basis of integrin signaling as it pertains to development, vascular biology and cancer. In this context, integrin signaling is required for the proliferation and differentiation of stem cells and hematopoietic progenitors into megakaryocytes, for platelet function in hemostasis and thrombosis, for endothelial cell participation in wound healing and angiogenesis, and for tumor progression. Recent work from this laboratory using complementary experimental systems, including human platelets, genetically-modified mice, zebrafish and animal models of neoplasia, indicates that integrin signaling is initiated by their interaction with specific protein kinases, phosphatases and molecular adapters. A current challenge is to integrate the wealth of information obtained from basic research into a complete understanding of integrin signaling, with diagnostic and therapeutic implications for cardiovascular and neoplastic diseases.

    Education and Training
    BA - Psychology, University of Illinois - 1961-1964
    MD - University of Illinois College of Medicine - 1964-1968
    Intern/Resident - Boston City Hospital (Harvard) - 1968-1970
    Fellow - Hematology, Boston City Hospital, Thorndike Lab, Harvard - 1970-1971

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Outside-In Integrin Signaling in Platelets
    NIH/NHLBI R01HL087939Apr 1, 2007 - Jan 31, 2008
    Role: Principal Investigator
    Cell Adhesion Mechanisms in Vascular Disease & Thrombosis
    NIH/NHLBI P01HL078784Dec 1, 2004 - Nov 30, 2009
    Role: Co-Investigator
    TRANSCRIPTION FACTOR NF-E2 IN ALPHA IIB BETA 3 SIGNALING
    NIH/NHLBI R01HL065198Aug 1, 2000 - Jul 31, 2006
    Role: Principal Investigator
    Integrin Signaling in Hemostasis and Blood Diseases
    NIH/NHLBI P01HL057900Apr 1, 1997 - Mar 31, 2007
    Role: Principal Investigator
    Discoveries at the Crossroads of Integrin and Inflammatory Signaling in Platelets
    NIH/NHLBI R01HL056595Jul 1, 1996 - May 31, 2021
    Role: Principal Investigator
    PLATELET SUFACE ACTIVATION IN HEMOSTASIS AND THROMBOSIS
    NIH/NHLBI R01HL049845Apr 1, 1993 - Mar 31, 1994
    Role: Principal Investigator
    CELL ADHESION MECHANISMS IN VASCULAR DISEASE
    NIH/NHLBI P01HL048728Sep 30, 1992 - Sep 29, 1999
    Role: Co-Investigator
    Regulation of Platelet and Endothelial Cell Function
    NIH P01HL040387Apr 1, 1988 - Apr 30, 2019
    Role: Co-Investigator
    MECHANISMS OF SIGNAL TRANSDUCTION IN HUMAN PLATELETS
    NIH/NHLBI R01HL026523Dec 1, 1980 - Nov 30, 1988
    Role: Principal Investigator
    Hematology clinical research training program
    NIH/NHLBI T32HL007439Jul 1, 1979 - Jun 30, 2024
    Role: Principal Investigator
    GENERAL CLINICAL RESEARCH CENTER
    NIH M01RR000833Dec 1, 1977 - Sep 30, 2005
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia. Nucleic Acid Ther. 2020 Apr; 30(2):94-103. Narayanan P, Curtis BR, Shen L, Schneider E, Tami JA, Paz S, Burel SA, Tai LJ, Machemer T, Kwoh TJ, Xia S, Shattil SJ, Witztum JL, Engelhardt JA, Henry SP, Monia BP, Hughes SG. PMID: 32043907.
      View in: PubMed   Mentions:    Fields:    
    2. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019 04 02; 129(5):1946-1959. Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J. PMID: 30730305.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    3. SHARPIN at the nexus of integrin, immune, and inflammatory signaling in human platelets. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):4983-4988. Kasirer-Friede A, Tjahjono W, Eto K, Shattil SJ. PMID: 30804189.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. NCCN Guidelines Insights: Cancer-Associated Venous Thromboembolic Disease, Version 2.2018. J Natl Compr Canc Netw. 2018 11; 16(11):1289-1303. Streiff MB, Holmstrom B, Angelini D, Ashrani A, Bockenstedt PL, Chesney C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Gundabolu K, Hendrie P, Lee AI, Lee JT, Mann J, McMahon B, Millenson MM, Morton C, Ortel TL, Ozair S, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Williams E, Zakarija A, Hammond L, Dwyer MA, Engh AM. PMID: 30442731.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    5. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv. 2018 09 25; 2(18):2358-2368. Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. PMID: 30242097.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Optogenetic interrogation of integrin aVß3 function in endothelial cells. J Cell Sci. 2017 Oct 15; 130(20):3532-3541. Liao Z, Kasirer-Friede A, Shattil SJ. PMID: 28864764.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Blood's 70th anniversary: musings of a Blood editor, 2003-2007. Blood. 2016 06 02; 127(22):2649-51. Shattil SJ. PMID: 27257172.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Integrin-based therapeutics: biological basis, clinical use and new drugs. Nat Rev Drug Discov. 2016 Mar; 15(3):173-83. Ley K, Rivera-Nieves J, Sandborn WJ, Shattil S. PMID: 26822833.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    9. Cancer-Associated Venous Thromboembolic Disease, Version 1.2015. J Natl Compr Canc Netw. 2015 Sep; 13(9):1079-95. Streiff MB, Holmstrom B, Ashrani A, Bockenstedt PL, Chesney C, Eby C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Hendrie P, Kuderer N, Lee A, Lee JT, Lovrincevic M, Millenson MM, Neff AT, Ortel TL, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Yee GC, Zakarija A, McMillian N, Engh AM. PMID: 26358792.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    10. Interaction of kindlin-2 with integrin ß3 promotes outside-in signaling responses by the aVß3 vitronectin receptor. Blood. 2015 Mar 19; 125(12):1995-2004. Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg MH, Shattil SJ. PMID: 25587038.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    11. Integrin avß3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell. 2014 Aug 11; 30(3):295-308. Desgrosellier JS, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil SJ, Cheresh DA. PMID: 25117682.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    12. The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design. Cell Host Microbe. 2014 Jun 11; 15(6):729-740. van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. PMID: 24922575.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    13. C-terminal COOH of integrin ß1 is necessary for ß1 association with the kindlin-2 adapter protein. J Biol Chem. 2014 Apr 18; 289(16):11183-93. Fitzpatrick P, Shattil SJ, Ablooglu AJ. PMID: 24599960.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. ADAP interactions with talin and kindlin promote platelet integrin aIIbß3 activation and stable fibrinogen binding. Blood. 2014 May 15; 123(20):3156-65. Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ. PMID: 24523237.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    15. The mechanism of kindlin-mediated activation of integrin aIIbß3. Curr Biol. 2013 Nov 18; 23(22):2288-2295. Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg MH. PMID: 24210614.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    16. Cutaneous thrombosis in PNH. Blood. 2013 Nov 07; 122(19):3249. Zhao H, Shattil S. PMID: 24354009.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated ß1 integrin and induction of FAK/PI3K/Akt motility signaling. Oncogene. 2014 Jan 09; 33(2):255-68. Casar B, Rimann I, Kato H, Shattil SJ, Quigley JP, Deryugina EI. PMID: 23208492.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    18. The primacy of ß1 integrin activation in the metastatic cascade. PLoS One. 2012; 7(10):e46576. Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ. PMID: 23056350.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    19. Kindlins, integrin activation and the regulation of talin recruitment to aIIbß3. PLoS One. 2012; 7(3):e34056. Kahner BN, Kato H, Banno A, Ginsberg MH, Shattil SJ, Ye F. PMID: 22457811.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene. 2012 May 31; 31(22):2783-93. Huang M, Anand S, Murphy EA, Desgrosellier JS, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA. PMID: 21963850.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    21. Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci. 2011 Mar 15; 124(Pt 6):879-91. Qu H, Tu Y, Shi X, Larjava H, Saleem MA, Shattil SJ, Fukuda K, Qin J, Kretzler M, Wu C. PMID: 21325030.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    22. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. PMID: 21177494.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    23. What is vinculin needed for in platelets? J Thromb Haemost. 2010 Oct; 8(10):2294-304. Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil SJ. PMID: 20670372.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development. 2010 Oct; 137(20):3449-58. Ablooglu AJ, Tkachenko E, Kang J, Shattil SJ. PMID: 20843856.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    25. Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci. 2010 Jul 01; 123(Pt 13):2332-41. Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S, Klemke R. PMID: 20530574.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    26. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol. 2010 Apr; 11(4):288-300. Shattil SJ, Kim C, Ginsberg MH. PMID: 20308986.
      View in: PubMed   Mentions: 305     Fields:    Translation:HumansAnimalsCells
    27. Role for ADAP in shear flow-induced platelet mechanotransduction. Blood. 2010 Mar 18; 115(11):2274-82. Kasirer-Friede A, Ruggeri ZM, Shattil SJ. PMID: 19996090.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    28. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med. 2009 Oct; 15(10):1163-9. Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil SJ, Cheresh DA. PMID: 19734908.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    29. The beta3 integrin cytoplasmic tail: protein scaffold and control freak. J Thromb Haemost. 2009 Jul; 7 Suppl 1:210-3. Shattil SJ. PMID: 19630802.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    30. RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem. 2009 Feb 20; 284(8):5119-27. Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH. PMID: 19098287.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    31. Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood. 2009 Apr 09; 113(15):3585-92. Ablooglu AJ, Kang J, Petrich BG, Ginsberg MH, Shattil SJ. PMID: 19005179.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    32. The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood. 2008 Oct 15; 112(8):3011-25. Coller BS, Shattil SJ. PMID: 18840725.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimals
    33. Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets. Blood. 2009 Jan 08; 113(2):447-57. Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil SJ. PMID: 18840708.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    34. Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip. 2008 Sep; 8(9):1486-95. Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A. PMID: 18818803.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    35. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. PMID: 18573917.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    36. Differences in regulation of Drosophila and vertebrate integrin affinity by talin. Mol Biol Cell. 2008 Aug; 19(8):3589-98. Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Féral CC, Ginsberg MH, Brower DL, Shattil SJ. PMID: 18508915.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    37. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood. 2008 Jan 15; 111(2):596-604. Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil SJ, Kaushansky K. PMID: 17925492.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    38. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn. 2007 Aug; 236(8):2268-76. Ablooglu AJ, Kang J, Handin RI, Traver D, Shattil SJ. PMID: 17626277.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    39. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest. 2007 Aug; 117(8):2250-9. Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH. PMID: 17627302.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    40. Platelet integrins and immunoreceptors. Immunol Rev. 2007 Aug; 218:247-64. Kasirer-Friede A, Kahn ML, Shattil SJ. PMID: 17624957.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    41. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol. 2007 Mar 12; 176(6):877-88. Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil SJ, Ginsberg MH, Ross FP, Teitelbaum SL. PMID: 17353363.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    42. Platelet integrin adhesive functions and signaling. Methods Enzymol. 2007; 426:103-15. Prévost N, Kato H, Bodin L, Shattil SJ. PMID: 17697882.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    43. Bloodlines: the importance of mentoring for the future of hematology. Blood. 2007 Feb 15; 109(4):1353-4. Kaushansky K, Shattil SJ. PMID: 17047145.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists. Blood. 2007 Feb 01; 109(3):1018-25. Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, Shattil SJ. PMID: 17003372.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    45. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol. 2006 Sep 19; 16(18):1796-806. Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH. PMID: 16979556.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    46. Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol. 2006 Sep; 26(18):6936-49. Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA. PMID: 16943434.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    47. Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell. 2006 Nov; 17(11):4686-97. Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. PMID: 16928957.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    48. A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost. 2006 Mar; 4(3):648-55. Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ. PMID: 16460447.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    49. Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function. J Thromb Haemost. 2006 Feb; 4(2):436-42. Gaur M, Kamata T, Wang S, Moran B, Shattil SJ, Leavitt AD. PMID: 16420577.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    50. Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity. J Biol Chem. 2006 Feb 24; 281(8):5050-7. Bunch TA, Helsten TL, Kendall TL, Shirahatti N, Mahadevan D, Shattil SJ, Brower DL. PMID: 16371365.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    51. Integrin regulation. Curr Opin Cell Biol. 2005 Oct; 17(5):509-16. Ginsberg MH, Partridge A, Shattil SJ. PMID: 16099636.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansCells
    52. PTP-1B is an essential positive regulator of platelet integrin signaling. J Cell Biol. 2005 Aug 29; 170(5):837-45. Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil SJ. PMID: 16115959.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    53. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 2005 Aug; 15(8):399-403. Shattil SJ. PMID: 16005629.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    54. Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem. 2005 Aug 19; 280(33):29699-707. Arias-Salgado EG, Lizano S, Shattil SJ, Ginsberg MH. PMID: 15937333.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    55. Letter to authors and readers regarding the new NIH policy on public access. Blood. 2005 May 15; 105(10):3767. George JN, Shattil SJ. PMID: 15817680.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    56. Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem. 2005 Jan 07; 280(1):644-53. Buensuceso CS, Obergfell A, Soriani A, Eto K, Kiosses WB, Arias-Salgado EG, Kawakami T, Shattil SJ. PMID: 15536078.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    57. Protein-protein interactions in platelet alphaIIbbeta3 signaling. Semin Thromb Hemost. 2004 Aug; 30(4):427-39. Buensuceso CS, Arias-Salgado EG, Shattil SJ. PMID: 15354264.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    58. Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood. 2004 Sep 15; 104(6):1606-15. Shattil SJ, Newman PJ. PMID: 15205259.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    59. Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells. J Cell Biol. 2004 May 10; 165(3):305-11. de Virgilio M, Kiosses WB, Shattil SJ. PMID: 15123737.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    60. Open access, yes! Open excess, no! Blood. 2004 May 01; 103(9):3257. Shattil SJ. PMID: 15096439.
      View in: PubMed   Mentions: 1     Fields:    
    61. Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation. Blood. 2004 Sep 01; 104(5):1327-34. Kerrigan SW, Gaur M, Murphy RP, Shattil SJ, Leavitt AD. PMID: 15059849.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    62. Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors. Blood. 2004 May 01; 103(9):3403-11. Kasirer-Friede A, Cozzi MR, Mazzucato M, De Marco L, Ruggeri ZM, Shattil SJ. PMID: 14726383.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    63. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13298-302. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. PMID: 14593208.
      View in: PubMed   Mentions: 198     Fields:    Translation:AnimalsCells
    64. Talin binding to integrin beta tails: a final common step in integrin activation. Science. 2003 Oct 03; 302(5642):103-6. Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA. PMID: 14526080.
      View in: PubMed   Mentions: 398     Fields:    Translation:HumansAnimalsCells
    65. Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. J Thromb Haemost. 2003 Jun; 1(6):1150-7. Arya M, López JA, Romo GM, Cruz MA, Kasirer-Friede A, Shattil SJ, Anvari B. PMID: 12871313.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    66. A (blood) smear campaign. Blood. 2003 Apr 01; 101(7):2453. Shattil SJ. PMID: 12642341.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    67. Detection of integrin alpha IIbbeta 3 clustering in living cells. J Biol Chem. 2003 Apr 25; 278(17):15217-24. Buensuceso C, de Virgilio M, Shattil SJ. PMID: 12595537.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    68. Development and analysis of megakaryocytes from murine embryonic stem cells. Methods Enzymol. 2003; 365:142-58. Eto K, Leavitt AL, Nakano T, Shattil SJ. PMID: 14696343.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    69. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12819-24. Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD, Shattil SJ. PMID: 12239348.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    70. The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem. 2002 Oct 18; 277(42):39401-8. Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH. PMID: 12171941.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    71. Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets. Biochem J. 2002 Jun 15; 364(Pt 3):755-65. Wonerow P, Obergfell A, Wilde JI, Bobe R, Asazuma N, Brdicka T, Leo A, Schraven B, Horejsí V, Shattil SJ, Watson SP. PMID: 12049640.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    72. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J Biol Chem. 2002 Jul 12; 277(28):25715-21. Bertoni A, Tadokoro S, Eto K, Pampori N, Parise LV, White GC, Shattil SJ. PMID: 11994301.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    73. The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. EMBO J. 2002 Apr 15; 21(8):1957-66. Baron W, Shattil SJ, ffrench-Constant C. PMID: 11953315.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    74. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002 Apr 15; 157(2):265-75. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ. PMID: 11940607.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    75. Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med. 2002 Mar 18; 195(6):705-17. Judd BA, Myung PS, Obergfell A, Myers EE, Cheng AM, Watson SP, Pear WS, Allman D, Shattil SJ, Koretzky GA. PMID: 11901197.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    76. Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3. J Biol Chem. 2002 Apr 05; 277(14):11949-56. Kasirer-Friede A, Ware J, Leng L, Marchese P, Ruggeri ZM, Shattil SJ. PMID: 11812775.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    77. Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr Biol. 2001 Nov 13; 11(22):1799-804. Woodside DG, Obergfell A, Leng L, Wilsbacher JL, Miranti CK, Brugge JS, Shattil SJ, Ginsberg MH. PMID: 11719224.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    78. The T cell receptor SLAPs integrins together. Nat Immunol. 2001 Oct; 2(10):904-5. Woodside DG, Shattil SJ, Ginsberg MH. PMID: 11577344.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    79. Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J. 2001 Sep 03; 20(17):4639-47. Tzima E, del Pozo MA, Shattil SJ, Chien S, Schwartz MA. PMID: 11532928.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    80. Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide. Thromb Haemost. 2001 Sep; 86(3):894-901. Derrick JM, Shattil SJ, Poncz M, Gruppo RA, Gartner TK. PMID: 11583324.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    81. All in the family: primary megakaryocytes for studies of platelet alphaIIbbeta3 signaling. Thromb Haemost. 2001 Jul; 86(1):259-65. Shattil SJ, Leavitt AD. PMID: 11487014.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    82. Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol. 2001 Mar; 3(3):316-20. Kiosses WB, Shattil SJ, Pampori N, Schwartz MA. PMID: 11231584.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    83. Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1853-8. Felding-Habermann B, O'Toole TE, Smith JW, Fransvea E, Ruggeri ZM, Ginsberg MH, Hughes PE, Pampori N, Shattil SJ, Saven A, Mueller BM. PMID: 11172040.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    84. Ligand binding to integrin alpha(v)beta(3) requires tyrosine 178 in the alpha(v) subunit. Blood. 2001 Jan 01; 97(1):175-82. Honda S, Tomiyama Y, Pampori N, Kashiwagi H, Kiyoi T, Kosugi S, Tadokoro S, Kurata Y, Shattil SJ, Matsuzawa Y. PMID: 11133758.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    85. The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. J Biol Chem. 2001 Feb 23; 276(8):5916-23. Obergfell A, Judd BA, del Pozo MA, Schwartz MA, Koretzky GA, Shattil SJ. PMID: 11113155.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    86. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12056-61. Judd BA, Myung PS, Leng L, Obergfell A, Pear WS, Shattil SJ, Koretzky GA. PMID: 11050236.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    87. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol Cell. 2000 Oct; 6(4):851-60. Byzova TV, Goldman CK, Pampori N, Thomas KA, Bett A, Shattil SJ, Plow EF. PMID: 11090623.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansCells
    88. Signaling networks linking integrins and rho family GTPases. Trends Biochem Sci. 2000 Aug; 25(8):388-91. Schwartz MA, Shattil SJ. PMID: 10916159.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    89. Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem. 2000 Jul 28; 275(30):22607-10. Calderwood DA, Shattil SJ, Ginsberg MH. PMID: 10801899.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    90. Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. J Cell Biol. 1999 Dec 27; 147(7):1419-30. Shiraga M, Ritchie A, Aidoudi S, Baron V, Wilcox D, White G, Ybarrondo B, Murphy G, Leavitt A, Shattil S. PMID: 10613901.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    91. Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways. Thromb Haemost. 1999 Aug; 82(2):318-25. Shattil SJ. PMID: 10605720.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    92. Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem. 1999 Jul 30; 274(31):21609-16. Pampori N, Hato T, Stupack DG, Aidoudi S, Cheresh DA, Nemerow GR, Shattil SJ. PMID: 10419468.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    93. Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. Blood. 1999 Apr 15; 93(8):2645-52. Law DA, Nannizzi-Alaimo L, Ministri K, Hughes PE, Forsyth J, Turner M, Shattil SJ, Ginsberg MH, Tybulewicz VL, Phillips DR. PMID: 10194444.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    94. A mutation in the extracellular cysteine-rich repeat region of the beta3 subunit activates integrins alphaIIbbeta3 and alphaVbeta3. Blood. 1999 Apr 15; 93(8):2559-68. Kashiwagi H, Tomiyama Y, Tadokoro S, Honda S, Shiraga M, Mizutani H, Handa M, Kurata Y, Matsuzawa Y, Shattil SJ. PMID: 10194435.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    95. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr Biol. 1998 Dec 03; 8(24):1289-99. Miranti CK, Leng L, Maschberger P, Brugge JS, Shattil SJ. PMID: 9843681.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    96. Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3. J Cell Biol. 1998 Jun 29; 141(7):1685-95. Hato T, Pampori N, Shattil SJ. PMID: 9647659.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    97. RhoA and the function of platelet integrin alphaIIbbeta3. Blood. 1998 Jun 01; 91(11):4206-15. Leng L, Kashiwagi H, Ren XD, Shattil SJ. PMID: 9596668.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    98. Integrin signaling: the platelet paradigm. Blood. 1998 Apr 15; 91(8):2645-57. Shattil SJ, Kashiwagi H, Pampori N. PMID: 9531572.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    99. Integrin signaling in vascular biology. J Clin Invest. 1997 Dec 01; 100(11 Suppl):S91-5. Shattil SJ, Ginsberg MH. PMID: 9413409.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    100. Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J. 1997 Nov 03; 16(21):6414-25. Gao J, Zoller KE, Ginsberg MH, Brugge JS, Shattil SJ. PMID: 9351824.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    101. Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. J Clin Invest. 1997 Nov 01; 100(9):2393-403. Wang R, Shattil SJ, Ambruso DR, Newman PJ. PMID: 9351872.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    102. Effect of Ca2+ on GP IIb-IIIa interactions with integrilin: enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate. Circulation. 1997 Sep 02; 96(5):1488-94. Phillips DR, Teng W, Arfsten A, Nannizzi-Alaimo L, White MM, Longhurst C, Shattil SJ, Randolph A, Jakubowski JA, Jennings LK, Scarborough RM. PMID: 9315536.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    103. Not just another pretty face: regulation of platelet function at the cytoplasmic face of integrin alpha IIb beta 3. Thromb Haemost. 1997 Jul; 78(1):220-5. Shattil SJ, Gao J, Kashiwagi H. PMID: 9198157.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    104. Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology. J Clin Invest. 1997 Jul 01; 100(1):1-5. Shattil SJ, Ginsberg MH. PMID: 9202049.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    105. Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail. J Cell Biol. 1997 Jun 16; 137(6):1433-43. Kashiwagi H, Schwartz MA, Eigenthaler M, Davis KA, Ginsberg MH, Shattil SJ. PMID: 9182673.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    106. A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin. J Biol Chem. 1997 Mar 21; 272(12):7693-8. Eigenthaler M, Höfferer L, Shattil SJ, Ginsberg MH. PMID: 9065427.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    107. A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1973-8. Baker EK, Tozer EC, Pfaff M, Shattil SJ, Loftus JC, Ginsberg MH. PMID: 9050889.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    108. A molecular basis for affinity modulation of Fab ligand binding to integrin alphaIIb beta3. J Biol Chem. 1996 Aug 23; 271(34):20315-21. Kunicki TJ, Annis DS, Deng YJ, Loftus JC, Shattil SJ. PMID: 8702765.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    109. Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3. Blood. 1996 Jul 01; 88(1):167-73. Basani RB, Vilaire G, Shattil SJ, Kolodziej MA, Bennett JS, Poncz M. PMID: 8704171.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    110. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem. 1996 Mar 22; 271(12):6571-4. Hughes PE, Diaz-Gonzalez F, Leong L, Wu C, McDonald JA, Shattil SJ, Ginsberg MH. PMID: 8636068.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    111. The platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin. J Biol Chem. 1996 Mar 22; 271(12):7004-11. Fox JE, Shattil SJ, Kinlough-Rathbone RL, Richardson M, Packham MA, Sanan DA. PMID: 8636130.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    112. Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbbeta3 integrin. J Biol Chem. 1996 Mar 15; 271(11):6265-72. Zhang J, Zhang J, Shattil SJ, Cunningham MC, Rittenhouse SE. PMID: 8626420.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    113. Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK. J Cell Sci. 1995 Dec; 108 ( Pt 12):3817-25. Leong L, Hughes PE, Schwartz MA, Ginsberg MH, Shattil SJ. PMID: 8719888.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    114. Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol. 1995 Nov; 131(3):807-16. Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH. PMID: 7593198.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    115. Function and regulation of the beta 3 integrins in hemostasis and vascular biology. Thromb Haemost. 1995 Jul; 74(1):149-55. Shattil SJ. PMID: 8578448.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    116. The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J Biol Chem. 1995 May 26; 270(21):12411-7. Hughes PE, O'Toole TE, Ylänne J, Shattil SJ, Ginsberg MH. PMID: 7759482.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    117. An enzyme-linked immunosorbent assay to identify inhibitors of activation of platelet integrin alpha IIb beta 3. J Immunol Methods. 1995 Apr 12; 181(1):55-64. Gao J, Shattil SJ. PMID: 7537313.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    118. Flow cytometric studies of platelet responses to shear stress in whole blood. Biorheology. 1995 Jan-Feb; 32(1):73-93. Konstantopoulos K, Wu KK, Udden MM, Bañez EI, Shattil SJ, Hellums JD. PMID: 7548862.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    119. Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. J Biol Chem. 1994 Nov 18; 269(46):28859-64. Clark EA, Shattil SJ, Ginsberg MH, Bolen J, Brugge JS. PMID: 7961845.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    120. Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci. 1994 Nov; 19(11):464-9. Clark EA, Shattil SJ, Brugge JS. PMID: 7855888.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    121. Adhesive signaling in platelets. Curr Opin Cell Biol. 1994 Oct; 6(5):695-704. Shattil SJ, Ginsberg MH, Brugge JS. PMID: 7530462.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    122. Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3. J Biol Chem. 1994 Jul 22; 269(29):18781-8. Abrams C, Deng YJ, Steiner B, O'Toole T, Shattil SJ. PMID: 7518445.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    123. "Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains. J Biol Chem. 1994 Jul 15; 269(28):18307-10. Chen YP, O'Toole TE, Shipley T, Forsyth J, LaFlamme SE, Yamada KM, Shattil SJ, Ginsberg MH. PMID: 8034576.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    124. Interaction of disintegrins with the alpha IIb beta 3 receptor on resting and activated human platelets. Biochem J. 1994 Jul 15; 301 ( Pt 2):429-36. McLane MA, Kowalska MA, Silver L, Shattil SJ, Niewiarowski S. PMID: 8042985.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    125. Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem. 1994 May 20; 269(20):14738-45. Shattil SJ, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS. PMID: 7514181.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    126. Sex hormones, complement-mediated platelet damage, and hemostasis. J Lab Clin Med. 1994 Apr; 123(4):464-6. Cines D, Shattil S. PMID: 8144994.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    127. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol. 1994 Mar; 124(6):1047-59. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH. PMID: 7510712.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCells
    128. Bioactive Arg-Gly-Asp conformations in anti-integrin GPIIb-IIIa antibodies. Receptor. 1994; 4(2):93-108. Prammer KV, Boyer J, Ugen K, Shattil SJ, Kieber-Emmons T. PMID: 7524891.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    129. Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. J Clin Invest. 1994 Jan; 93(1):172-9. Poncz M, Rifat S, Coller BS, Newman PJ, Shattil SJ, Parrella T, Fortina P, Bennett JS. PMID: 8282784.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    130. Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIa. J Biol Chem. 1993 Oct 05; 268(28):21080-7. Ugarova TP, Budzynski AZ, Shattil SJ, Ruggeri ZM, Ginsberg MH, Plow EF. PMID: 7691805.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    131. Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem. 1993 Jul 25; 268(21):15868-77. Haimovich B, Lipfert L, Brugge JS, Shattil SJ. PMID: 8340412.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    132. Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol. 1993 Jul; 122(2):473-83. Huang MM, Lipfert L, Cunningham M, Brugge JS, Ginsberg MH, Shattil SJ. PMID: 7686553.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    133. Regulation of platelet anchorage and signaling by integrin alpha IIb beta 3. Thromb Haemost. 1993 Jul 01; 70(1):224-8. Shattil SJ. PMID: 7694387.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    134. Why is platelet activation useful for assessing thrombotic risk? What are the advantages and limitations of using flow cytometry to measure platelet activation? Am J Clin Nutr. 1992 10; 56(4 Suppl):789S-790S. Shattil SJ. PMID: 1414981.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    135. Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J Biol Chem. 1992 Sep 15; 267(26):18424-31. Shattil SJ, Cunningham M, Wiedmer T, Zhao J, Sims PJ, Brass LF. PMID: 1326524.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    136. A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3. J Biol Chem. 1992 Sep 05; 267(25):18085-92. Tomiyama Y, Brojer E, Ruggeri ZM, Shattil SJ, Smiltneck J, Gorski J, Kumar A, Kieber-Emmons T, Kunicki TJ. PMID: 1517241.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    137. Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J Biol Chem. 1992 Jun 05; 267(16):11300-6. Savage B, Shattil SJ, Ruggeri ZM. PMID: 1597464.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    138. Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen. J Biol Chem. 1992 Feb 05; 267(4):2775-85. Abrams CS, Ruggeri ZM, Taub R, Hoxie JA, Nagaswami C, Weisel JW, Shattil SJ. PMID: 1370832.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    139. Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome. Blood. 1992 Jan 15; 79(2):380-8. Bevers EM, Wiedmer T, Comfurius P, Shattil SJ, Weiss HJ, Zwaal RF, Sims PJ. PMID: 1730083.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    140. Early changes in cytosolic calcium and membrane potential induced by Actinobacillus actinomycetemcomitans leukotoxin in susceptible and resistant target cells. J Immunol. 1991 Nov 15; 147(10):3587-94. Taichman NS, Iwase M, Lally ET, Shattil SJ, Cunningham ME, Korchak HM. PMID: 1940358.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    141. Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science. 1991 Nov 08; 254(5033):845-7. O'Toole TE, Mandelman D, Forsyth J, Shattil SJ, Plow EF, Ginsberg MH. PMID: 1948065.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    142. Protein tyrosine phosphorylation and the adhesive functions of platelets. Curr Opin Cell Biol. 1991 Oct; 3(5):869-79. Shattil SJ, Brugge JS. PMID: 1931088.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    143. Platelet-derived microparticles express high affinity receptors for factor VIII. J Biol Chem. 1991 Sep 15; 266(26):17261-8. Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shattil SJ. PMID: 1654328.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    144. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7844-8. Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS. PMID: 1715582.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    145. Immunological detection of activated platelets in clinical disorders. Thromb Haemost. 1991 May 06; 65(5):467-73. Abrams C, Shattil SJ. PMID: 1871706.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    146. Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J Biol Chem. 1991 Apr 25; 266(12):7345-52. Sims PJ, Ginsberg MH, Plow EF, Shattil SJ. PMID: 1902217.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    147. Decreased content and surface expression of alpha-granule membrane protein GMP-140 in one of two types of platelet alpha delta storage pool deficiency. J Clin Invest. 1991 Mar; 87(3):919-29. Lages B, Shattil SJ, Bainton DF, Weiss HJ. PMID: 1705568.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    148. The clinical importance of acquired abnormalities of platelet function. N Engl J Med. 1991 Jan 03; 324(1):27-39. George JN, Shattil SJ. PMID: 1984161.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    149. GTP-binding proteins and platelet activation. Prog Hemost Thromb. 1991; 10:127-74. Brass LF, Manning DR, Shattil SJ. PMID: 1848944.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    150. Use of monoclonal antibodies for the detection and analysis of activated human platelets. Curr Stud Hematol Blood Transfus. 1991; (58):26-31. Shattil S. PMID: 1954770.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    151. Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins. J Cell Biol. 1990 Dec; 111(6 Pt 2):3117-27. Golden A, Brugge JS, Shattil SJ. PMID: 1702789.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    152. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood. 1990 Nov 15; 76(10):2017-23. Ginsberg MH, Frelinger AL, Lam SC, Forsyth J, McMillan R, Plow EF, Shattil SJ. PMID: 2242424.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    153. Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul. 1990 Nov; 1(12):883-93. O'Toole TE, Loftus JC, Du XP, Glass AA, Ruggeri ZM, Shattil SJ, Plow EF, Ginsberg MH. PMID: 2100193.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    154. Platelet activation induces increased Fc gamma receptor expression. J Immunol. 1990 May 15; 144(10):3920-7. McCrae KR, Shattil SJ, Cines DB. PMID: 2139675.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    155. Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor. Biochemistry. 1990 Jan 23; 29(3):623-32. Wiedmer T, Shattil SJ, Cunningham M, Sims PJ. PMID: 2159784.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    156. Direct detection of activated platelets and platelet-derived microparticles in humans. Blood. 1990 Jan 01; 75(1):128-38. Abrams CS, Ellison N, Budzynski AZ, Shattil SJ. PMID: 2294986.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    157. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity. J Biol Chem. 1989 Oct 15; 264(29):17049-57. Sims PJ, Wiedmer T, Esmon CT, Weiss HJ, Shattil SJ. PMID: 2793843.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    158. A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J Biol Chem. 1989 Jan 05; 264(1):259-65. Taub R, Gould RJ, Garsky VM, Ciccarone TM, Hoxie J, Friedman PA, Shattil SJ. PMID: 2909518.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    159. Interaction of extracellular calcium with the surface membrane of human platelets. Methods Enzymol. 1989; 169:355-71. Brass LF, Shattil SJ. PMID: 2654565.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    160. Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists. Blood. 1989 Jan; 73(1):150-8. Shattil SJ, Budzynski A, Scrutton MC. PMID: 2535942.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    161. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J Biol Chem. 1988 Dec 05; 263(34):18205-12. Sims PJ, Faioni EM, Wiedmer T, Shattil SJ. PMID: 2848029.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    162. Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex. J Biol Chem. 1988 Sep 15; 263(26):12948-53. Bennett JS, Shattil SJ, Power JW, Gartner TK. PMID: 3417645.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    163. Broadband continuous-wave laser. Opt Lett. 1988 Aug 01; 13(8):622. Kowalski FV, Hale PD, Shattil SJ. PMID: 19745983.
      View in: PubMed   Mentions:    Fields:    
    164. Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation. J Biol Chem. 1988 Apr 15; 263(11):5210-6. Brass LF, Shattil SJ. PMID: 2833498.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    165. Expression, regulation and detection of fibrinogen receptors on activated human platelets. Prog Clin Biol Res. 1988; 283:345-80. Shattil SJ. PMID: 3062628.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    166. Prototype quantitative assay for fibrinogen/fibrin degradation products. Clinical evaluation. Arch Intern Med. 1987 Oct; 147(10):1790-3. Sigal SH, Cembrowski GS, Shattil SJ, Brown NM, Schifreen RS, Schwartz MW. PMID: 3662708.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    167. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood. 1987 Jul; 70(1):307-15. Shattil SJ, Cunningham M, Hoxie JA. PMID: 3297204.
      View in: PubMed   Mentions: 83     Fields:    Translation:Cells
    168. The efficacy of intensive plasma exchange in acquired von Willebrand's disease. Transfusion. 1987 May-Jun; 27(3):234-7. Silberstein LE, Abrahm J, Shattil SJ. PMID: 3109084.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    169. Induction of the fibrinogen receptor on human platelets by intracellular mediators. J Biol Chem. 1987 Jan 25; 262(3):992-1000. Shattil SJ, Brass LF. PMID: 3100533.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    170. Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine. Blood. 1986 Dec; 68(6):1224-31. Shattil SJ, Motulsky HJ, Insel PA, Flaherty L, Brass LF. PMID: 3779100.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    171. Desensitization of epinephrine-initiated platelet aggregation does not alter binding to the alpha 2-adrenergic receptor or receptor coupling to adenylate cyclase. Mol Pharmacol. 1986 Jan; 29(1):1-6. Motulsky HJ, Shattil SJ, Ferry N, Rozansky D, Insel PA. PMID: 2418346.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    172. Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. J Biol Chem. 1985 Sep 15; 260(20):11107-14. Shattil SJ, Hoxie JA, Cunningham M, Brass LF. PMID: 2411729.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansCells
    173. Effect of calcium on the stability of the platelet membrane glycoprotein IIb-IIIa complex. J Biol Chem. 1985 Jul 05; 260(13):7875-81. Brass LF, Shattil SJ, Kunicki TJ, Bennett JS. PMID: 2409078.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    174. Biochemical and functional consequences of dissociation of the platelet membrane glycoprotein IIb-IIIa complex. Blood. 1985 Jul; 66(1):92-8. Shattil SJ, Brass LF, Bennett JS, Pandhi P. PMID: 3159447.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    175. The interaction of extracellular calcium with the platelet membrane glycoprotein IIb-IIIa complex. Nouv Rev Fr Hematol. 1985; 27(4):211-7. Shattil SJ, Brass LF. PMID: 2997701.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    176. Diagnosis and treatment of recurrent venous thromboembolism. Med Clin North Am. 1984 May; 68(3):577-600. Shattil SJ. PMID: 6379336.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    177. Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets. J Clin Invest. 1984 Mar; 73(3):626-32. Brass LF, Shattil SJ. PMID: 6231306.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    178. The prevention of prosthetic valve thromboembolism. Uses and limitations of anti-platelet drugs. Int J Cardiol. 1983 Apr; 3(1):87-91. Shattil SJ, Brass LF. PMID: 6852996.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    179. Changes in surface-bound and exchangeable calcium during platelet activation. J Biol Chem. 1982 Dec 10; 257(23):14000-5. Brass LF, Shattil SJ. PMID: 7142191.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    180. The effect of pharmacologic inhibition of phospholipid methylation on human platelet function. Blood. 1982 May; 59(5):906-12. Shattil SJ, Montgomery JA, Chiang PK. PMID: 7074219.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    181. Interaction of verapamil with human platelet alpha-adrenergic receptors. Am J Physiol. 1982 Jan; 242(1):H19-23. Barnathan ES, Addonizio VP, Shattil SJ. PMID: 6277203.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    182. Inhibition of platelet phospholipid methylation during platelet secretion. Blood. 1981 Mar; 57(3):537-44. Shattil SJ, McDonough M, Burch JW. PMID: 6779878.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    183. Platelets and their membranes in hemostasis: physiology and pathophysiology. Ann Intern Med. 1981 Jan; 94(1):108-18. Shattil SJ, Bennett JS. PMID: 7004296.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    184. Characterization of alpha-adrenergic receptors in human platelets using [3H]clonidine. Mol Pharmacol. 1981 Jan; 19(1):179-83. Shattil SJ, McDonough M, Turnbull J, Insel PA. PMID: 6259509.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    185. Characterization of alpha 2-adrenergic receptors on human platelets using [3H]yohimbine. Biochem Biophys Res Commun. 1980 Dec 31; 97(4):1562-70. Motulsky HJ, Shattil SJ, Insel PA. PMID: 6260094.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    186. Carbenicillin and penicillin G inhibit platelet function in vitro by impairing the interaction of agonists with the platelet surface. J Clin Invest. 1980 Feb; 65(2):329-37. Shattil SJ, Bennett JS, McDonough M, Turnbull J. PMID: 6243309.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    187. Membrane cholesterol--is enough too much? N Engl J Med. 1980 Jan 03; 302(1):49-51. Cooper RA, Shattil SJ. PMID: 7350397.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    188. Relationship of cholesterol supply to luteal mitochondrial steroid synthesis. J Biol Chem. 1979 May 25; 254(10):3977-82. Toaff ME, Strauss JF, Flickinger GL, Shattil SJ. PMID: 438171.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    189. Relationships between cholesterol supply and luteal mitochondrial steroid synthesis. Adv Exp Med Biol. 1979; 112:541-3. Toaff ME, Flickinger GL, Strauss JF, Shattil SJ. PMID: 463628.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    190. Relationships between membrane cholesterol, alpha-adrenergic receptors, and platelet function. Biochemistry. 1978 Nov 28; 17(24):5269-74. Insel PA, Nirenberg P, Turnbull J, Shattil SJ. PMID: 215196.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    191. Platelet function in essential thrombocythemia. Decreased epinephrine responsiveness associated with a deficiency of platelet alpha-adrenergic receptors. N Engl J Med. 1978 Sep 07; 299(10):505-9. Kaywin P, McDonough M, Insel PA, Shattil SJ. PMID: 210377.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    192. Increased fluidity of human platelet membranes during complement-mediated immune platelet injury. J Clin Invest. 1978 Mar; 61(3):582-9. Shattil SJ, Cines DB, Schreiber AD. PMID: 641139.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    193. Factors influencing the lipid composition and fluidity of red cell membranes in vitro: production of red cells possessing more than two cholesterols per phospholipid. Biochemistry. 1978 Jan 24; 17(2):327-31. Cooper RA, Leslie MH, Fischkoff S, Shinitzky M, Shattil SJ. PMID: 619993.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    194. Role of membrane lipid composition, organization, and fluidity in human platelet function. Prog Hemost Thromb. 1978; 4:59-86. Shattil SJ, Cooper RA. PMID: 362482.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    195. Cyclic AMP metabolism in cholesterol-rich platelets. J Biol Chem. 1977 May 25; 252(10):3310-4. Sinha AK, Shattil SJ, Colman RW. PMID: 193833.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    196. Abnormalities of cholesterol-phospholipid composition in platelets and low-density lipoproteins of human hyperbetalipoproteinemia. J Lab Clin Med. 1977 Feb; 89(2):341-53. Shattil SJ, Bennett JS, Colman RW, Cooper RA. PMID: 188956.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    197. Membrane microviscosity and human platelet function. Biochemistry. 1976 Nov 02; 15(22):4832-7. Shattil SJ, Cooper RA. PMID: 990246.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    198. Halofenate: a potent inhibitor of normal and hypersensitive platelets. J Lab Clin Med. 1976 Aug; 88(2):282-91. Colman RW, Bennett JS, Sheridan JF, Cooper RA, Shattil SJ. PMID: 956686.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    199. Soluble fibrin complexes in coronary disease. Thromb Res. 1976 Aug; 9(2):153-65. Anaya-Galindo R, Shattil SJ, Shelburne JC, Colman RW. PMID: 788221.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    200. Platelet hypersensitivity induced by cholesterol incorporation. J Clin Invest. 1975 Mar; 55(3):636-43. Shattil SJ, Anaya-Galindo R, Bennett J, Colman RW, Cooper RA. PMID: 1117069.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    201. Modification of red cell membrane structure by cholesterol-rich lipid dispersions. A model for the primary spur cell defect. J Clin Invest. 1975 Jan; 55(1):115-26. Cooper RA, Arner EC, Wiley JS, Shattil SJ. PMID: 162782.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    202. Metabolic complications of aggressive therapy of chronic lymphocytic leukemia. Am J Med Sci. 1974 May; 267(5):311-4. Morse BM, Shattil SJ. PMID: 4833837.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    203. M-components. JAMA. 1973 Jan 08; 223(2):156-9. Abramson N, Shattil SJ. PMID: 4631886.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    204. Maturation of macroreticulocyte membranes in vivo. J Lab Clin Med. 1972 Feb; 79(2):215-27. Shattil SJ, Cooper RA. PMID: 5009711.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    205. Mechanisms of hemolysis--the minimal red-cell defect. N Engl J Med. 1971 Dec 30; 285(27):1514-20. Cooper RA, Shattil SJ. PMID: 4942489.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    206. The red cell membrane in hemolytic anemia. Mod Treat. 1971 May; 8(2):329-51. Cooper RA, Shattil SJ. PMID: 4940517.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
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