Sanford Shattil

Title(s)Distinguished Professor, Medicine
SchoolHealth Sciences
Phone858-822-6425
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    Collapse Overview 
    Collapse Overview
    Research Interests
    Signaling Through Integrin Adhesion Receptors in Development, Vascular Biology and Cancer.

    Integrins represent a ubiquitous family of transmembrane adhesion receptors that transfer biological information between the extracellular and intracellular environments. The general term “integrin signaling” is often used to refer to this process, which is involved in regulating biological events as diverse as embryonic development, synaptic plasticity of the nervous system, innate and adaptive immunity, and the functions of circulating blood cells. Integrin signaling encompasses both “inside-out” signals that regulate integrin affinity and avidity for extracellular ligands and “outside-in” signals that regulate anchorage-dependent cellular responses, such as cell motility and changes in gene expression. Defects in integrin signaling promote certain vascular, inflammatory and neoplastic disorders. The focus of this laboratory is to unravel the molecular basis of integrin signaling as it pertains to development, vascular biology and cancer. In this context, integrin signaling is required for the proliferation and differentiation of stem cells and hematopoietic progenitors into megakaryocytes, for platelet function in hemostasis and thrombosis, for endothelial cell participation in wound healing and angiogenesis, and for tumor progression. Recent work from this laboratory using complementary experimental systems, including human platelets, genetically-modified mice, zebrafish and animal models of neoplasia, indicates that integrin signaling is initiated by their interaction with specific protein kinases, phosphatases and molecular adapters. A current challenge is to integrate the wealth of information obtained from basic research into a complete understanding of integrin signaling, with diagnostic and therapeutic implications for cardiovascular and neoplastic diseases.

    Education and Training
    BA - Psychology, University of Illinois - 1961-1964
    MD - University of Illinois College of Medicine - 1964-1968
    Intern/Resident - Boston City Hospital (Harvard) - 1968-1970
    Fellow - Hematology, Boston City Hospital, Thorndike Lab, Harvard - 1970-1971

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Outside-In Integrin Signaling in Platelets
    NIH R01HL087939Apr 1, 2007 - Jan 31, 2008
    Role: Principal Investigator
    Cell Adhesion Mechanisms in Vascular Disease & Thrombosis
    NIH P01HL078784Dec 1, 2004 - Apr 30, 2021
    Role: Co-Investigator
    TRANSCRIPTION FACTOR NF-E2 IN ALPHA IIB BETA 3 SIGNALING
    NIH R01HL065198Aug 1, 2000 - Jul 31, 2006
    Role: Principal Investigator
    Integrin Signaling in Hemostasis and Blood Diseases
    NIH P01HL057900Apr 1, 1997 - Jan 31, 2014
    Role: Principal Investigator
    Discoveries at the Crossroads of Integrin and Inflammatory Signaling in Platelets
    NIH R01HL056595Jul 1, 1996 - May 31, 2021
    Role: Principal Investigator
    PLATELET SUFACE ACTIVATION IN HEMOSTASIS AND THROMBOSIS
    NIH R01HL049845Apr 1, 1993 - Mar 31, 1994
    Role: Principal Investigator
    CELL ADHESION MECHANISMS IN VASCULAR DISEASE
    NIH P01HL048728Sep 30, 1992 - Aug 31, 2004
    Role: Co-Investigator
    Regulation of Platelet and Endothelial Cell Function
    NIH P01HL040387Apr 1, 1988 - Apr 30, 2019
    Role: Co-Investigator
    MECHANISMS OF SIGNAL TRANSDUCTION IN HUMAN PLATELETS
    NIH R01HL026523Dec 1, 1980 - Nov 30, 1988
    Role: Principal Investigator
    Hematology clinical research training program
    NIH T32HL007439Jul 1, 1979 - Jun 30, 2024
    Role: Principal Investigator
    GENERAL CLINICAL RESEARCH CENTER
    NIH M01RR000833Dec 1, 1977 - Sep 30, 2005
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Optogenetic-based Localization of Talin to the Plasma Membrane Promotes Activation of ß3 Integrins. J Biol Chem. 2021 Apr 15; 100675. Liao Z, Gingras AR, Lagarrigue F, Ginsberg MH, Shattil SJ. PMID: 33865854.
      View in: PubMed   Mentions:    Fields:    
    2. Genetic Instruction of Megakaryocytes and Platelets Derived from Human Induced Pluripotent Stem Cells for Studies of Integrin Regulation. Methods Mol Biol. 2021; 2217:237-249. Kasirer-Friede A, Shattil SJ. PMID: 33215384.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia. Nucleic Acid Ther. 2020 04; 30(2):94-103. Narayanan P, Curtis BR, Shen L, Schneider E, Tami JA, Paz S, Burel SA, Tai LJ, Machemer T, Kwoh TJ, Xia S, Shattil SJ, Witztum JL, Engelhardt JA, Henry SP, Monia BP, Hughes SG. PMID: 32043907.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    4. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019 04 02; 129(5):1946-1959. Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J. PMID: 30730305.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    5. SHARPIN at the nexus of integrin, immune, and inflammatory signaling in human platelets. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):4983-4988. Kasirer-Friede A, Tjahjono W, Eto K, Shattil SJ. PMID: 30804189.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. NCCN Guidelines Insights: Cancer-Associated Venous Thromboembolic Disease, Version 2.2018. J Natl Compr Canc Netw. 2018 11; 16(11):1289-1303. Streiff MB, Holmstrom B, Angelini D, Ashrani A, Bockenstedt PL, Chesney C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Gundabolu K, Hendrie P, Lee AI, Lee JT, Mann J, McMahon B, Millenson MM, Morton C, Ortel TL, Ozair S, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Williams E, Zakarija A, Hammond L, Dwyer MA, Engh AM. PMID: 30442731.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    7. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv. 2018 09 25; 2(18):2358-2368. Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. PMID: 30242097.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. Optogenetic interrogation of integrin aVß3 function in endothelial cells. J Cell Sci. 2017 Oct 15; 130(20):3532-3541. Liao Z, Kasirer-Friede A, Shattil SJ. PMID: 28864764.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    9. Blood's 70th anniversary: musings of a Blood editor, 2003-2007. Blood. 2016 06 02; 127(22):2649-51. Shattil SJ. PMID: 27257172.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Integrin-based therapeutics: biological basis, clinical use and new drugs. Nat Rev Drug Discov. 2016 Mar; 15(3):173-83. Ley K, Rivera-Nieves J, Sandborn WJ, Shattil S. PMID: 26822833.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    11. Cancer-Associated Venous Thromboembolic Disease, Version 1.2015. J Natl Compr Canc Netw. 2015 Sep; 13(9):1079-95. Streiff MB, Holmstrom B, Ashrani A, Bockenstedt PL, Chesney C, Eby C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Hendrie P, Kuderer N, Lee A, Lee JT, Lovrincevic M, Millenson MM, Neff AT, Ortel TL, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Yee GC, Zakarija A, McMillian N, Engh AM. PMID: 26358792.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    12. Interaction of kindlin-2 with integrin ß3 promotes outside-in signaling responses by the aVß3 vitronectin receptor. Blood. 2015 Mar 19; 125(12):1995-2004. Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg MH, Shattil SJ. PMID: 25587038.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    13. Integrin avß3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell. 2014 Aug 11; 30(3):295-308. Desgrosellier JS, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil SJ, Cheresh DA. PMID: 25117682.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    14. The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design. Cell Host Microbe. 2014 Jun 11; 15(6):729-740. van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. PMID: 24922575.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    15. C-terminal COOH of integrin ß1 is necessary for ß1 association with the kindlin-2 adapter protein. J Biol Chem. 2014 Apr 18; 289(16):11183-11193. Fitzpatrick P, Shattil SJ, Ablooglu AJ. PMID: 24599960.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. ADAP interactions with talin and kindlin promote platelet integrin aIIbß3 activation and stable fibrinogen binding. Blood. 2014 May 15; 123(20):3156-65. Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ. PMID: 24523237.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    17. Cutaneous thrombosis in PNH. Blood. 2013 Nov 07; 122(19):3249. Zhao H, Shattil S. PMID: 24354009.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Sleeve lobectomy for non-small cell lung cancer with N1 nodal disease does not compromise survival. Ann Thorac Surg. 2014 Jan; 97(1):230-5. Berry MF, Worni M, Wang X, Harpole DH, D'Amico TA, Onaitis MW. PMID: 24210614.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    19. The primacy of ß1 integrin activation in the metastatic cascade. PLoS One. 2012; 7(10):e46576. Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ. PMID: 23056350.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    20. Kindlins, integrin activation and the regulation of talin recruitment to aIIbß3. PLoS One. 2012; 7(3):e34056. Kahner BN, Kato H, Banno A, Ginsberg MH, Shattil SJ, Ye F. PMID: 22457811.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    21. Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci. 2011 Mar 15; 124(Pt 6):879-91. Qu H, Tu Y, Shi X, Larjava H, Saleem MA, Shattil SJ, Fukuda K, Qin J, Kretzler M, Wu C. PMID: 21325030.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    22. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. PMID: 21177494.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    23. Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development. 2010 Oct; 137(20):3449-58. Ablooglu AJ, Tkachenko E, Kang J, Shattil SJ. PMID: 20843856.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    24. Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci. 2010 Jul 01; 123(Pt 13):2332-41. Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S, Klemke R. PMID: 20530574.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    25. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol. 2010 Apr; 11(4):288-300. Shattil SJ, Kim C, Ginsberg MH. PMID: 20308986.
      View in: PubMed   Mentions: 364     Fields:    Translation:HumansAnimalsCells
    26. Role for ADAP in shear flow-induced platelet mechanotransduction. Blood. 2010 Mar 18; 115(11):2274-82. Kasirer-Friede A, Ruggeri ZM, Shattil SJ. PMID: 19996090.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    27. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med. 2009 Oct; 15(10):1163-9. Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil SJ, Cheresh DA. PMID: 19734908.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    28. The beta3 integrin cytoplasmic tail: protein scaffold and control freak. J Thromb Haemost. 2009 Jul; 7 Suppl 1:210-3. Shattil SJ. PMID: 19630802.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    29. RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem. 2009 Feb 20; 284(8):5119-27. Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH. PMID: 19098287.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    30. Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood. 2009 Apr 09; 113(15):3585-92. Ablooglu AJ, Kang J, Petrich BG, Ginsberg MH, Shattil SJ. PMID: 19005179.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    31. The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood. 2008 Oct 15; 112(8):3011-25. Coller BS, Shattil SJ. PMID: 18840725.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimals
    32. Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets. Blood. 2009 Jan 08; 113(2):447-57. Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil SJ. PMID: 18840708.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    33. Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip. 2008 Sep; 8(9):1486-95. Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A. PMID: 18818803.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    34. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. PMID: 18573917.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    35. Differences in regulation of Drosophila and vertebrate integrin affinity by talin. Mol Biol Cell. 2008 Aug; 19(8):3589-98. Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Féral CC, Ginsberg MH, Brower DL, Shattil SJ. PMID: 18508915.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood. 2008 Jan 15; 111(2):596-604. Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil SJ, Kaushansky K. PMID: 17925492.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    37. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn. 2007 Aug; 236(8):2268-76. Ablooglu AJ, Kang J, Handin RI, Traver D, Shattil SJ. PMID: 17626277.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    38. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest. 2007 Aug; 117(8):2250-9. Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH. PMID: 17627302.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    39. Platelet integrins and immunoreceptors. Immunol Rev. 2007 Aug; 218:247-64. Kasirer-Friede A, Kahn ML, Shattil SJ. PMID: 17624957.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    40. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol. 2007 Mar 12; 176(6):877-88. Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil SJ, Ginsberg MH, Ross FP, Teitelbaum SL. PMID: 17353363.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    41. Platelet integrin adhesive functions and signaling. Methods Enzymol. 2007; 426:103-15. Prévost N, Kato H, Bodin L, Shattil SJ. PMID: 17697882.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. Bloodlines: the importance of mentoring for the future of hematology. Blood. 2007 Feb 15; 109(4):1353-4. Kaushansky K, Shattil SJ. PMID: 17047145.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists. Blood. 2007 Feb 01; 109(3):1018-25. Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, Shattil SJ. PMID: 17003372.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    44. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol. 2006 Sep 19; 16(18):1796-806. Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH. PMID: 16979556.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    45. Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol. 2006 Sep; 26(18):6936-49. Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA. PMID: 16943434.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    46. Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell. 2006 Nov; 17(11):4686-97. Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. PMID: 16928957.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    47. Arsenite pre-conditioning reduces UVB-induced apoptosis in corneal epithelial cells through the anti-apoptotic activity of 27 kDa heat shock protein (HSP27). J Cell Physiol. 2006 Feb; 206(2):301-8. Shi B, Isseroff RR. PMID: 16115959.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    48. Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity. J Biol Chem. 2006 Feb 24; 281(8):5050-7. Bunch TA, Helsten TL, Kendall TL, Shirahatti N, Mahadevan D, Shattil SJ, Brower DL. PMID: 16371365.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    49. Integrin regulation. Curr Opin Cell Biol. 2005 Oct; 17(5):509-16. Ginsberg MH, Partridge A, Shattil SJ. PMID: 16099636.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansCells
    50. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 2005 Aug; 15(8):399-403. Shattil SJ. PMID: 16005629.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    51. Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem. 2005 Aug 19; 280(33):29699-707. Arias-Salgado EG, Lizano S, Shattil SJ, Ginsberg MH. PMID: 15937333.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    52. Letter to authors and readers regarding the new NIH policy on public access. Blood. 2005 May 15; 105(10):3767. George JN, Shattil SJ. PMID: 15817680.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem. 2005 Jan 07; 280(1):644-53. Buensuceso CS, Obergfell A, Soriani A, Eto K, Kiosses WB, Arias-Salgado EG, Kawakami T, Shattil SJ. PMID: 15536078.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    54. Protein-protein interactions in platelet alphaIIbbeta3 signaling. Semin Thromb Hemost. 2004 Aug; 30(4):427-39. Buensuceso CS, Arias-Salgado EG, Shattil SJ. PMID: 15354264.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    55. Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood. 2004 Sep 15; 104(6):1606-15. Shattil SJ, Newman PJ. PMID: 15205259.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    56. Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells. J Cell Biol. 2004 May 10; 165(3):305-11. de Virgilio M, Kiosses WB, Shattil SJ. PMID: 15123737.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    57. Open access, yes! Open excess, no! Blood. 2004 May 01; 103(9):3257. Shattil SJ. PMID: 15096439.
      View in: PubMed   Mentions: 1     Fields:    
    58. Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation. Blood. 2004 Sep 01; 104(5):1327-34. Kerrigan SW, Gaur M, Murphy RP, Shattil SJ, Leavitt AD. PMID: 15059849.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    59. Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors. Blood. 2004 May 01; 103(9):3403-11. Kasirer-Friede A, Cozzi MR, Mazzucato M, De Marco L, Ruggeri ZM, Shattil SJ. PMID: 14726383.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    60. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13298-302. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. PMID: 14593208.
      View in: PubMed   Mentions: 219     Fields:    Translation:AnimalsCells
    61. Talin binding to integrin beta tails: a final common step in integrin activation. Science. 2003 Oct 03; 302(5642):103-6. Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA. PMID: 14526080.
      View in: PubMed   Mentions: 441     Fields:    Translation:HumansAnimalsCells
    62. A (blood) smear campaign. Blood. 2003 Apr 01; 101(7):2453. Shattil SJ. PMID: 12642341.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    63. Detection of integrin alpha IIbbeta 3 clustering in living cells. J Biol Chem. 2003 Apr 25; 278(17):15217-24. Buensuceso C, de Virgilio M, Shattil SJ. PMID: 12595537.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    64. Development and analysis of megakaryocytes from murine embryonic stem cells. Methods Enzymol. 2003; 365:142-58. Eto K, Leavitt AL, Nakano T, Shattil SJ. PMID: 14696343.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    65. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12819-24. Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD, Shattil SJ. PMID: 12239348.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    66. The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem. 2002 Oct 18; 277(42):39401-8. Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH. PMID: 12171941.
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    67. Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets. Biochem J. 2002 Jun 15; 364(Pt 3):755-65. Wonerow P, Obergfell A, Wilde JI, Bobe R, Asazuma N, Brdicka T, Leo A, Schraven B, Horejsí V, Shattil SJ, Watson SP. PMID: 12049640.
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    68. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J Biol Chem. 2002 Jul 12; 277(28):25715-21. Bertoni A, Tadokoro S, Eto K, Pampori N, Parise LV, White GC, Shattil SJ. PMID: 11994301.
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    69. The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. EMBO J. 2002 Apr 15; 21(8):1957-66. Baron W, Shattil SJ, ffrench-Constant C. PMID: 11953315.
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    70. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002 Apr 15; 157(2):265-75. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ. PMID: 11940607.
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    71. Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med. 2002 Mar 18; 195(6):705-17. Judd BA, Myung PS, Obergfell A, Myers EE, Cheng AM, Watson SP, Pear WS, Allman D, Shattil SJ, Koretzky GA. PMID: 11901197.
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    72. Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3. J Biol Chem. 2002 Apr 05; 277(14):11949-56. Kasirer-Friede A, Ware J, Leng L, Marchese P, Ruggeri ZM, Shattil SJ. PMID: 11812775.
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    73. Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. J Cell Biol. 1999 Dec 27; 147(7):1419-30. Shiraga M, Ritchie A, Aidoudi S, Baron V, Wilcox D, White G, Ybarrondo B, Murphy G, Leavitt A, Shattil S. PMID: 10613901.
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