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Sanford Shattil

Title(s)Distinguished Professor, Medicine
SchoolHealth Sciences
Phone858-822-6425
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    Collapse Overview 
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    Research Interests
    Signaling Through Integrin Adhesion Receptors in Development, Vascular Biology and Cancer.

    Integrins represent a ubiquitous family of transmembrane adhesion receptors that transfer biological information between the extracellular and intracellular environments. The general term “integrin signaling” is often used to refer to this process, which is involved in regulating biological events as diverse as embryonic development, synaptic plasticity of the nervous system, innate and adaptive immunity, and the functions of circulating blood cells. Integrin signaling encompasses both “inside-out” signals that regulate integrin affinity and avidity for extracellular ligands and “outside-in” signals that regulate anchorage-dependent cellular responses, such as cell motility and changes in gene expression. Defects in integrin signaling promote certain vascular, inflammatory and neoplastic disorders. The focus of this laboratory is to unravel the molecular basis of integrin signaling as it pertains to development, vascular biology and cancer. In this context, integrin signaling is required for the proliferation and differentiation of stem cells and hematopoietic progenitors into megakaryocytes, for platelet function in hemostasis and thrombosis, for endothelial cell participation in wound healing and angiogenesis, and for tumor progression. Recent work from this laboratory using complementary experimental systems, including human platelets, genetically-modified mice, zebrafish and animal models of neoplasia, indicates that integrin signaling is initiated by their interaction with specific protein kinases, phosphatases and molecular adapters. A current challenge is to integrate the wealth of information obtained from basic research into a complete understanding of integrin signaling, with diagnostic and therapeutic implications for cardiovascular and neoplastic diseases.

    Education and Training
    BA - Psychology, University of Illinois - 1961-1964
    MD - University of Illinois College of Medicine - 1964-1968
    Intern/Resident - Boston City Hospital (Harvard) - 1968-1970
    Fellow - Hematology, Boston City Hospital, Thorndike Lab, Harvard - 1970-1971

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Outside-In Integrin Signaling in Platelets
    NIH/NHLBI R01HL087939Apr 1, 2007 - Jan 31, 2008
    Role: Principal Investigator
    Cell Adhesion Mechanisms in Vascular Disease & Thrombosis
    NIH/NHLBI P01HL078784Dec 1, 2004 - Apr 30, 2020
    Role: Co-Investigator
    TRANSCRIPTION FACTOR NF-E2 IN ALPHA IIB BETA 3 SIGNALING
    NIH/NHLBI R01HL065198Aug 1, 2000 - Jul 31, 2006
    Role: Principal Investigator
    Integrin Signaling in Hemostasis and Blood Diseases
    NIH/NHLBI P01HL057900Apr 1, 1997 - Jan 31, 2014
    Role: Principal Investigator
    Discoveries at the Crossroads of Integrin and Inflammatory Signaling in Platelets
    NIH/NHLBI R01HL056595Jul 1, 1996 - May 31, 2021
    Role: Principal Investigator
    PLATELET SUFACE ACTIVATION IN HEMOSTASIS AND THROMBOSIS
    NIH/NHLBI R01HL049845Apr 1, 1993 - Mar 31, 1994
    Role: Principal Investigator
    CELL ADHESION MECHANISMS IN VASCULAR DISEASE
    NIH/NHLBI P01HL048728Sep 30, 1992 - Aug 31, 2004
    Role: Co-Investigator
    Regulation of Platelet and Endothelial Cell Function
    NIH P01HL040387Apr 1, 1988 - Apr 30, 2019
    Role: Co-Investigator
    MECHANISMS OF SIGNAL TRANSDUCTION IN HUMAN PLATELETS
    NIH/NHLBI R01HL026523Dec 1, 1980 - Nov 30, 1988
    Role: Principal Investigator
    Hematology clinical research training program
    NIH/NHLBI T32HL007439Jul 1, 1979 - Jun 30, 2024
    Role: Principal Investigator
    GENERAL CLINICAL RESEARCH CENTER
    NIH M01RR000833Dec 1, 1977 - Sep 30, 2005
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019 Apr 02; 130. PMID: 30730305.
      View in: PubMed
    2. Kasirer-Friede A, Tjahjono W, Eto K, Shattil SJ. SHARPIN at the nexus of integrin, immune, and inflammatory signaling in human platelets. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):4983-4988. PMID: 30804189.
      View in: PubMed
    3. Streiff MB, Holmstrom B, Angelini D, Ashrani A, Bockenstedt PL, Chesney C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Gundabolu K, Hendrie P, Lee AI, Lee JT, Mann J, McMahon B, Millenson MM, Morton C, Ortel TL, Ozair S, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Williams E, Zakarija A, Hammond L, Dwyer MA, Engh AM. NCCN Guidelines Insights: Cancer-Associated Venous Thromboembolic Disease, Version 2.2018. J Natl Compr Canc Netw. 2018 Nov; 16(11):1289-1303. PMID: 30442731.
      View in: PubMed
    4. Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv. 2018 Sep 25; 2(18):2358-2368. PMID: 30242097.
      View in: PubMed
    5. Liao Z, Kasirer-Friede A, Shattil SJ. Optogenetic interrogation of integrin aVß3 function in endothelial cells. J Cell Sci. 2017 Oct 15; 130(20):3532-3541. PMID: 28864764.
      View in: PubMed
    6. Shattil SJ. Blood's 70th anniversary: musings of a Blood editor, 2003-2007. Blood. 2016 06 02; 127(22):2649-51. PMID: 27257172.
      View in: PubMed
    7. Ley K, Rivera-Nieves J, Sandborn WJ, Shattil S. Integrin-based therapeutics: biological basis, clinical use and new drugs. Nat Rev Drug Discov. 2016 Mar; 15(3):173-83. PMID: 26822833.
      View in: PubMed
    8. Streiff MB, Holmstrom B, Ashrani A, Bockenstedt PL, Chesney C, Eby C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Hendrie P, Kuderer N, Lee A, Lee JT, Lovrincevic M, Millenson MM, Neff AT, Ortel TL, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Yee GC, Zakarija A, McMillian N, Engh AM. Cancer-Associated Venous Thromboembolic Disease, Version 1.2015. J Natl Compr Canc Netw. 2015 Sep; 13(9):1079-95. PMID: 26358792.
      View in: PubMed
    9. Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg MH, Shattil SJ. Interaction of kindlin-2 with integrin ß3 promotes outside-in signaling responses by the aVß3 vitronectin receptor. Blood. 2015 Mar 19; 125(12):1995-2004. PMID: 25587038; PMCID: PMC4366628.
    10. Desgrosellier JS, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil SJ, Cheresh DA. Integrin avß3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell. 2014 Aug 11; 30(3):295-308. PMID: 25117682; PMCID: PMC4147869.
    11. van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design. Cell Host Microbe. 2014 Jun 11; 15(6):729-740. PMID: 24922575; PMCID: PMC4078075.
    12. Fitzpatrick P, Shattil SJ, Ablooglu AJ. C-terminal COOH of integrin ß1 is necessary for ß1 association with the kindlin-2 adapter protein. J Biol Chem. 2014 Apr 18; 289(16):11183-93. PMID: 24599960; PMCID: PMC4036257.
    13. Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ. ADAP interactions with talin and kindlin promote platelet integrin aIIbß3 activation and stable fibrinogen binding. Blood. 2014 May 15; 123(20):3156-65. PMID: 24523237.
      View in: PubMed
    14. Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg MH. The mechanism of kindlin-mediated activation of integrin aIIbß3. Curr Biol. 2013 Nov 18; 23(22):2288-2295. PMID: 24210614.
      View in: PubMed
    15. Zhao H, Shattil S. Cutaneous thrombosis in PNH. Blood. 2013 Nov 07; 122(19):3249. PMID: 24354009.
      View in: PubMed
    16. Casar B, Rimann I, Kato H, Shattil SJ, Quigley JP, Deryugina EI. In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated ß1 integrin and induction of FAK/PI3K/Akt motility signaling. Oncogene. 2014 Jan 09; 33(2):255-68. PMID: 23208492.
      View in: PubMed
    17. Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ. The primacy of ß1 integrin activation in the metastatic cascade. PLoS One. 2012; 7(10):e46576. PMID: 23056350; PMCID: PMC3463578.
    18. Kahner BN, Kato H, Banno A, Ginsberg MH, Shattil SJ, Ye F. Kindlins, integrin activation and the regulation of talin recruitment to aIIbß3. PLoS One. 2012; 7(3):e34056. PMID: 22457811; PMCID: PMC3311585.
    19. Huang M, Anand S, Murphy EA, Desgrosellier JS, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA. EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene. 2012 May 31; 31(22):2783-93. PMID: 21963850; PMCID: PMC3711644.
    20. Qu H, Tu Y, Shi X, Larjava H, Saleem MA, Shattil SJ, Fukuda K, Qin J, Kretzler M, Wu C. Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci. 2011 Mar 15; 124(Pt 6):879-91. PMID: 21325030; PMCID: PMC3048888.
    21. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. PMID: 21177494; PMCID: PMC3093297.
    22. Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil SJ. What is vinculin needed for in platelets? J Thromb Haemost. 2010 Oct; 8(10):2294-304. PMID: 20670372; PMCID: PMC2965783.
    23. Ablooglu AJ, Tkachenko E, Kang J, Shattil SJ. Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development. 2010 Oct; 137(20):3449-58. PMID: 20843856; PMCID: PMC2947757.
    24. Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S, Klemke R. Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci. 2010 Jul 01; 123(Pt 13):2332-41. PMID: 20530574; PMCID: PMC2886748.
    25. Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol. 2010 Apr; 11(4):288-300. PMID: 20308986; PMCID: PMC3929966.
    26. Kasirer-Friede A, Ruggeri ZM, Shattil SJ. Role for ADAP in shear flow-induced platelet mechanotransduction. Blood. 2010 Mar 18; 115(11):2274-82. PMID: 19996090; PMCID: PMC2844019.
    27. Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil SJ, Cheresh DA. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med. 2009 Oct; 15(10):1163-9. PMID: 19734908; PMCID: PMC2759406.
    28. Shattil SJ. The beta3 integrin cytoplasmic tail: protein scaffold and control freak. J Thromb Haemost. 2009 Jul; 7 Suppl 1:210-3. PMID: 19630802.
      View in: PubMed
    29. Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH. RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem. 2009 Feb 20; 284(8):5119-27. PMID: 19098287; PMCID: PMC2643525.
    30. Ablooglu AJ, Kang J, Petrich BG, Ginsberg MH, Shattil SJ. Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood. 2009 Apr 09; 113(15):3585-92. PMID: 19005179; PMCID: PMC2668853.
    31. Coller BS, Shattil SJ. The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood. 2008 Oct 15; 112(8):3011-25. PMID: 18840725; PMCID: PMC2569161.
    32. Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil SJ. Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets. Blood. 2009 Jan 08; 113(2):447-57. PMID: 18840708; PMCID: PMC2615656.
    33. Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A. Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip. 2008 Sep; 8(9):1486-95. PMID: 18818803; PMCID: PMC2683765.
    34. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22. PMID: 18573917.
      View in: PubMed
    35. Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Féral CC, Ginsberg MH, Brower DL, Shattil SJ. Differences in regulation of Drosophila and vertebrate integrin affinity by talin. Mol Biol Cell. 2008 Aug; 19(8):3589-98. PMID: 18508915.
      View in: PubMed
    36. Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil SJ, Kaushansky K. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood. 2008 Jan 15; 111(2):596-604. PMID: 17925492; PMCID: PMC2200856.
    37. Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest. 2007 Aug; 117(8):2250-9. PMID: 17627302; PMCID: PMC1906732.
    38. Ablooglu AJ, Kang J, Handin RI, Traver D, Shattil SJ. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn. 2007 Aug; 236(8):2268-76. PMID: 17626277.
      View in: PubMed
    39. Kasirer-Friede A, Kahn ML, Shattil SJ. Platelet integrins and immunoreceptors. Immunol Rev. 2007 Aug; 218:247-64. PMID: 17624957.
      View in: PubMed
    40. Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil SJ, Ginsberg MH, Ross FP, Teitelbaum SL. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol. 2007 Mar 12; 176(6):877-88. PMID: 17353363; PMCID: PMC2064061.
    41. Prévost N, Kato H, Bodin L, Shattil SJ. Platelet integrin adhesive functions and signaling. Methods Enzymol. 2007; 426:103-15. PMID: 17697882.
      View in: PubMed
    42. Kaushansky K, Shattil SJ. Bloodlines: the importance of mentoring for the future of hematology. Blood. 2007 Feb 15; 109(4):1353-4. PMID: 17047145.
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    43. Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, Shattil SJ. ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists. Blood. 2007 Feb 01; 109(3):1018-25. PMID: 17003372; PMCID: PMC1785130.
    44. Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol. 2006 Sep 19; 16(18):1796-806. PMID: 16979556.
      View in: PubMed
    45. Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA. Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol. 2006 Sep; 26(18):6936-49. PMID: 16943434; PMCID: PMC1592869.
    46. Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell. 2006 Nov; 17(11):4686-97. PMID: 16928957.
      View in: PubMed
    47. Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ. A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost. 2006 Mar; 4(3):648-55. PMID: 16460447.
      View in: PubMed
    48. Gaur M, Kamata T, Wang S, Moran B, Shattil SJ, Leavitt AD. Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function. J Thromb Haemost. 2006 Feb; 4(2):436-42. PMID: 16420577.
      View in: PubMed
    49. Bunch TA, Helsten TL, Kendall TL, Shirahatti N, Mahadevan D, Shattil SJ, Brower DL. Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity. J Biol Chem. 2006 Feb 24; 281(8):5050-7. PMID: 16371365.
      View in: PubMed
    50. Ginsberg MH, Partridge A, Shattil SJ. Integrin regulation. Curr Opin Cell Biol. 2005 Oct; 17(5):509-16. PMID: 16099636.
      View in: PubMed
    51. Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil SJ. PTP-1B is an essential positive regulator of platelet integrin signaling. J Cell Biol. 2005 Aug 29; 170(5):837-45. PMID: 16115959; PMCID: PMC2171339.
    52. Shattil SJ. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 2005 Aug; 15(8):399-403. PMID: 16005629.
      View in: PubMed
    53. Arias-Salgado EG, Lizano S, Shattil SJ, Ginsberg MH. Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem. 2005 Aug 19; 280(33):29699-707. PMID: 15937333.
      View in: PubMed
    54. George JN, Shattil SJ. Letter to authors and readers regarding the new NIH policy on public access. Blood. 2005 May 15; 105(10):3767. PMID: 15817680.
      View in: PubMed
    55. Buensuceso CS, Obergfell A, Soriani A, Eto K, Kiosses WB, Arias-Salgado EG, Kawakami T, Shattil SJ. Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem. 2005 Jan 07; 280(1):644-53. PMID: 15536078.
      View in: PubMed
    56. Buensuceso CS, Arias-Salgado EG, Shattil SJ. Protein-protein interactions in platelet alphaIIbbeta3 signaling. Semin Thromb Hemost. 2004 Aug; 30(4):427-39. PMID: 15354264.
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    57. Shattil SJ, Newman PJ. Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood. 2004 Sep 15; 104(6):1606-15. PMID: 15205259.
      View in: PubMed
    58. de Virgilio M, Kiosses WB, Shattil SJ. Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells. J Cell Biol. 2004 May 10; 165(3):305-11. PMID: 15123737; PMCID: PMC2172182.
    59. Shattil SJ. Open access, yes! Open excess, no! Blood. 2004 May 01; 103(9):3257. PMID: 15096439.
      View in: PubMed
    60. Kerrigan SW, Gaur M, Murphy RP, Shattil SJ, Leavitt AD. Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation. Blood. 2004 Sep 01; 104(5):1327-34. PMID: 15059849.
      View in: PubMed
    61. Kasirer-Friede A, Cozzi MR, Mazzucato M, De Marco L, Ruggeri ZM, Shattil SJ. Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors. Blood. 2004 May 01; 103(9):3403-11. PMID: 14726383.
      View in: PubMed
    62. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13298-302. PMID: 14593208; PMCID: PMC263791.
    63. Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA. Talin binding to integrin beta tails: a final common step in integrin activation. Science. 2003 Oct 03; 302(5642):103-6. PMID: 14526080.
      View in: PubMed
    64. Arya M, López JA, Romo GM, Cruz MA, Kasirer-Friede A, Shattil SJ, Anvari B. Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. J Thromb Haemost. 2003 Jun; 1(6):1150-7. PMID: 12871313.
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    65. Shattil SJ. A (blood) smear campaign. Blood. 2003 Apr 01; 101(7):2453. PMID: 12642341.
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    66. Buensuceso C, de Virgilio M, Shattil SJ. Detection of integrin alpha IIbbeta 3 clustering in living cells. J Biol Chem. 2003 Apr 25; 278(17):15217-24. PMID: 12595537.
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    67. Eto K, Leavitt AL, Nakano T, Shattil SJ. Development and analysis of megakaryocytes from murine embryonic stem cells. Methods Enzymol. 2003; 365:142-58. PMID: 14696343.
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    68. Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD, Shattil SJ. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12819-24. PMID: 12239348; PMCID: PMC130543.
    69. Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH. The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem. 2002 Oct 18; 277(42):39401-8. PMID: 12171941.
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    70. Wonerow P, Obergfell A, Wilde JI, Bobe R, Asazuma N, Brdicka T, Leo A, Schraven B, Horejsí V, Shattil SJ, Watson SP. Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets. Biochem J. 2002 Jun 15; 364(Pt 3):755-65. PMID: 12049640; PMCID: PMC1222625.
    71. Bertoni A, Tadokoro S, Eto K, Pampori N, Parise LV, White GC, Shattil SJ. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J Biol Chem. 2002 Jul 12; 277(28):25715-21. PMID: 11994301.
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    72. Baron W, Shattil SJ, ffrench-Constant C. The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. EMBO J. 2002 Apr 15; 21(8):1957-66. PMID: 11953315; PMCID: PMC125971.
    73. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002 Apr 15; 157(2):265-75. PMID: 11940607; PMCID: PMC2199242.
    74. Judd BA, Myung PS, Obergfell A, Myers EE, Cheng AM, Watson SP, Pear WS, Allman D, Shattil SJ, Koretzky GA. Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med. 2002 Mar 18; 195(6):705-17. PMID: 11901197.
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    75. Kasirer-Friede A, Ware J, Leng L, Marchese P, Ruggeri ZM, Shattil SJ. Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3. J Biol Chem. 2002 Apr 05; 277(14):11949-56. PMID: 11812775.
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    76. Woodside DG, Obergfell A, Leng L, Wilsbacher JL, Miranti CK, Brugge JS, Shattil SJ, Ginsberg MH. Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr Biol. 2001 Nov 13; 11(22):1799-804. PMID: 11719224.
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    77. Woodside DG, Shattil SJ, Ginsberg MH. The T cell receptor SLAPs integrins together. Nat Immunol. 2001 Oct; 2(10):904-5. PMID: 11577344.
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    78. Tzima E, del Pozo MA, Shattil SJ, Chien S, Schwartz MA. Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J. 2001 Sep 03; 20(17):4639-47. PMID: 11532928.
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    79. Derrick JM, Shattil SJ, Poncz M, Gruppo RA, Gartner TK. Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide. Thromb Haemost. 2001 Sep; 86(3):894-901. PMID: 11583324.
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    80. Shattil SJ, Leavitt AD. All in the family: primary megakaryocytes for studies of platelet alphaIIbbeta3 signaling. Thromb Haemost. 2001 Jul; 86(1):259-65. PMID: 11487014.
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    81. Kiosses WB, Shattil SJ, Pampori N, Schwartz MA. Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol. 2001 Mar; 3(3):316-20. PMID: 11231584.
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    82. Felding-Habermann B, O'Toole TE, Smith JW, Fransvea E, Ruggeri ZM, Ginsberg MH, Hughes PE, Pampori N, Shattil SJ, Saven A, Mueller BM. Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1853-8. PMID: 11172040.
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    83. Honda S, Tomiyama Y, Pampori N, Kashiwagi H, Kiyoi T, Kosugi S, Tadokoro S, Kurata Y, Shattil SJ, Matsuzawa Y. Ligand binding to integrin alpha(v)beta(3) requires tyrosine 178 in the alpha(v) subunit. Blood. 2001 Jan 01; 97(1):175-82. PMID: 11133758.
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    84. Obergfell A, Judd BA, del Pozo MA, Schwartz MA, Koretzky GA, Shattil SJ. The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. J Biol Chem. 2001 Feb 23; 276(8):5916-23. PMID: 11113155.
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    85. Judd BA, Myung PS, Leng L, Obergfell A, Pear WS, Shattil SJ, Koretzky GA. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12056-61. PMID: 11050236.
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    86. Byzova TV, Goldman CK, Pampori N, Thomas KA, Bett A, Shattil SJ, Plow EF. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol Cell. 2000 Oct; 6(4):851-60. PMID: 11090623.
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    87. Schwartz MA, Shattil SJ. Signaling networks linking integrins and rho family GTPases. Trends Biochem Sci. 2000 Aug; 25(8):388-91. PMID: 10916159.
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    88. Calderwood DA, Shattil SJ, Ginsberg MH. Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem. 2000 Jul 28; 275(30):22607-10. PMID: 10801899.
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    89. Shiraga M, Ritchie A, Aidoudi S, Baron V, Wilcox D, White G, Ybarrondo B, Murphy G, Leavitt A, Shattil S. Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. J Cell Biol. 1999 Dec 27; 147(7):1419-30. PMID: 10613901.
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    90. Shattil SJ. Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways. Thromb Haemost. 1999 Aug; 82(2):318-25. PMID: 10605720.
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    91. Pampori N, Hato T, Stupack DG, Aidoudi S, Cheresh DA, Nemerow GR, Shattil SJ. Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem. 1999 Jul 30; 274(31):21609-16. PMID: 10419468.
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    92. Kashiwagi H, Tomiyama Y, Tadokoro S, Honda S, Shiraga M, Mizutani H, Handa M, Kurata Y, Matsuzawa Y, Shattil SJ. A mutation in the extracellular cysteine-rich repeat region of the beta3 subunit activates integrins alphaIIbbeta3 and alphaVbeta3. Blood. 1999 Apr 15; 93(8):2559-68. PMID: 10194435.
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    93. Law DA, Nannizzi-Alaimo L, Ministri K, Hughes PE, Forsyth J, Turner M, Shattil SJ, Ginsberg MH, Tybulewicz VL, Phillips DR. Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. Blood. 1999 Apr 15; 93(8):2645-52. PMID: 10194444.
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    94. Miranti CK, Leng L, Maschberger P, Brugge JS, Shattil SJ. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr Biol. 1998 Dec 03; 8(24):1289-99. PMID: 9843681.
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    95. Hato T, Pampori N, Shattil SJ. Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3. J Cell Biol. 1998 Jun 29; 141(7):1685-95. PMID: 9647659.
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    96. Leng L, Kashiwagi H, Ren XD, Shattil SJ. RhoA and the function of platelet integrin alphaIIbbeta3. Blood. 1998 Jun 01; 91(11):4206-15. PMID: 9596668.
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    97. Shattil SJ, Kashiwagi H, Pampori N. Integrin signaling: the platelet paradigm. Blood. 1998 Apr 15; 91(8):2645-57. PMID: 9531572.
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    98. Shattil SJ, Ginsberg MH. Integrin signaling in vascular biology. J Clin Invest. 1997 Dec 01; 100(11 Suppl):S91-5. PMID: 9413409.
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    99. Gao J, Zoller KE, Ginsberg MH, Brugge JS, Shattil SJ. Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J. 1997 Nov 03; 16(21):6414-25. PMID: 9351824.
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    100. Wang R, Shattil SJ, Ambruso DR, Newman PJ. Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. J Clin Invest. 1997 Nov 01; 100(9):2393-403. PMID: 9351872.
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    101. Phillips DR, Teng W, Arfsten A, Nannizzi-Alaimo L, White MM, Longhurst C, Shattil SJ, Randolph A, Jakubowski JA, Jennings LK, Scarborough RM. Effect of Ca2+ on GP IIb-IIIa interactions with integrilin: enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate. Circulation. 1997 Sep 02; 96(5):1488-94. PMID: 9315536.
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    102. Shattil SJ, Gao J, Kashiwagi H. Not just another pretty face: regulation of platelet function at the cytoplasmic face of integrin alpha IIb beta 3. Thromb Haemost. 1997 Jul; 78(1):220-5. PMID: 9198157.
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    103. Shattil SJ, Ginsberg MH. Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology. J Clin Invest. 1997 Jul 01; 100(1):1-5. PMID: 9202049.
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    104. Kashiwagi H, Schwartz MA, Eigenthaler M, Davis KA, Ginsberg MH, Shattil SJ. Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail. J Cell Biol. 1997 Jun 16; 137(6):1433-43. PMID: 9182673.
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    105. Eigenthaler M, Höfferer L, Shattil SJ, Ginsberg MH. A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin. J Biol Chem. 1997 Mar 21; 272(12):7693-8. PMID: 9065427.
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    106. Baker EK, Tozer EC, Pfaff M, Shattil SJ, Loftus JC, Ginsberg MH. A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1973-8. PMID: 9050889.
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    107. Kunicki TJ, Annis DS, Deng YJ, Loftus JC, Shattil SJ. A molecular basis for affinity modulation of Fab ligand binding to integrin alphaIIb beta3. J Biol Chem. 1996 Aug 23; 271(34):20315-21. PMID: 8702765.
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    108. Basani RB, Vilaire G, Shattil SJ, Kolodziej MA, Bennett JS, Poncz M. Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3. Blood. 1996 Jul 01; 88(1):167-73. PMID: 8704171.
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    109. Hughes PE, Diaz-Gonzalez F, Leong L, Wu C, McDonald JA, Shattil SJ, Ginsberg MH. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem. 1996 Mar 22; 271(12):6571-4. PMID: 8636068.
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    110. Fox JE, Shattil SJ, Kinlough-Rathbone RL, Richardson M, Packham MA, Sanan DA. The platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin. J Biol Chem. 1996 Mar 22; 271(12):7004-11. PMID: 8636130.
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    111. Zhang J, Zhang J, Shattil SJ, Cunningham MC, Rittenhouse SE. Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbbeta3 integrin. J Biol Chem. 1996 Mar 15; 271(11):6265-72. PMID: 8626420.
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    112. Leong L, Hughes PE, Schwartz MA, Ginsberg MH, Shattil SJ. Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK. J Cell Sci. 1995 Dec; 108 ( Pt 12):3817-25. PMID: 8719888.
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    113. Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH. Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol. 1995 Nov; 131(3):807-16. PMID: 7593198.
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    114. Shattil SJ. Function and regulation of the beta 3 integrins in hemostasis and vascular biology. Thromb Haemost. 1995 Jul; 74(1):149-55. PMID: 8578448.
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    115. Hughes PE, O'Toole TE, Ylänne J, Shattil SJ, Ginsberg MH. The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J Biol Chem. 1995 May 26; 270(21):12411-7. PMID: 7759482.
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    116. Gao J, Shattil SJ. An enzyme-linked immunosorbent assay to identify inhibitors of activation of platelet integrin alpha IIb beta 3. J Immunol Methods. 1995 Apr 12; 181(1):55-64. PMID: 7537313.
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    117. Konstantopoulos K, Wu KK, Udden MM, Bañez EI, Shattil SJ, Hellums JD. Flow cytometric studies of platelet responses to shear stress in whole blood. Biorheology. 1995 Jan-Feb; 32(1):73-93. PMID: 7548862.
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    118. Clark EA, Shattil SJ, Ginsberg MH, Bolen J, Brugge JS. Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. J Biol Chem. 1994 Nov 18; 269(46):28859-64. PMID: 7961845.
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    119. Clark EA, Shattil SJ, Brugge JS. Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci. 1994 Nov; 19(11):464-9. PMID: 7855888.
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    120. Shattil SJ, Ginsberg MH, Brugge JS. Adhesive signaling in platelets. Curr Opin Cell Biol. 1994 Oct; 6(5):695-704. PMID: 7530462.
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    121. Abrams C, Deng YJ, Steiner B, O'Toole T, Shattil SJ. Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3. J Biol Chem. 1994 Jul 22; 269(29):18781-8. PMID: 7518445.
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    122. Chen YP, O'Toole TE, Shipley T, Forsyth J, LaFlamme SE, Yamada KM, Shattil SJ, Ginsberg MH. "Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains. J Biol Chem. 1994 Jul 15; 269(28):18307-10. PMID: 8034576.
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    123. McLane MA, Kowalska MA, Silver L, Shattil SJ, Niewiarowski S. Interaction of disintegrins with the alpha IIb beta 3 receptor on resting and activated human platelets. Biochem J. 1994 Jul 15; 301 ( Pt 2):429-36. PMID: 8042985.
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    124. Shattil SJ, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS. Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem. 1994 May 20; 269(20):14738-45. PMID: 7514181.
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    125. Cines D, Shattil S. Sex hormones, complement-mediated platelet damage, and hemostasis. J Lab Clin Med. 1994 Apr; 123(4):464-6. PMID: 8144994.
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    126. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol. 1994 Mar; 124(6):1047-59. PMID: 7510712.
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    127. Prammer KV, Boyer J, Ugen K, Shattil SJ, Kieber-Emmons T. Bioactive Arg-Gly-Asp conformations in anti-integrin GPIIb-IIIa antibodies. Receptor. 1994; 4(2):93-108. PMID: 7524891.
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    128. Poncz M, Rifat S, Coller BS, Newman PJ, Shattil SJ, Parrella T, Fortina P, Bennett JS. Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. J Clin Invest. 1994 Jan; 93(1):172-9. PMID: 8282784.
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    129. Ugarova TP, Budzynski AZ, Shattil SJ, Ruggeri ZM, Ginsberg MH, Plow EF. Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIa. J Biol Chem. 1993 Oct 05; 268(28):21080-7. PMID: 7691805.
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    130. Haimovich B, Lipfert L, Brugge JS, Shattil SJ. Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem. 1993 Jul 25; 268(21):15868-77. PMID: 8340412.
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    131. Shattil SJ. Regulation of platelet anchorage and signaling by integrin alpha IIb beta 3. Thromb Haemost. 1993 Jul 01; 70(1):224-8. PMID: 7694387.
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    132. Huang MM, Lipfert L, Cunningham M, Brugge JS, Ginsberg MH, Shattil SJ. Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol. 1993 Jul; 122(2):473-83. PMID: 7686553.
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    133. Shattil SJ. Why is platelet activation useful for assessing thrombotic risk? What are the advantages and limitations of using flow cytometry to measure platelet activation? Am J Clin Nutr. 1992 10; 56(4 Suppl):789S-790S. PMID: 1414981.
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    134. Shattil SJ, Cunningham M, Wiedmer T, Zhao J, Sims PJ, Brass LF. Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J Biol Chem. 1992 Sep 15; 267(26):18424-31. PMID: 1326524.
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    135. Tomiyama Y, Brojer E, Ruggeri ZM, Shattil SJ, Smiltneck J, Gorski J, Kumar A, Kieber-Emmons T, Kunicki TJ. A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3. J Biol Chem. 1992 Sep 05; 267(25):18085-92. PMID: 1517241.
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    136. Savage B, Shattil SJ, Ruggeri ZM. Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J Biol Chem. 1992 Jun 05; 267(16):11300-6. PMID: 1597464.
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    137. Abrams CS, Ruggeri ZM, Taub R, Hoxie JA, Nagaswami C, Weisel JW, Shattil SJ. Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen. J Biol Chem. 1992 Feb 05; 267(4):2775-85. PMID: 1370832.
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    138. Bevers EM, Wiedmer T, Comfurius P, Shattil SJ, Weiss HJ, Zwaal RF, Sims PJ. Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome. Blood. 1992 Jan 15; 79(2):380-8. PMID: 1730083.
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    139. Taichman NS, Iwase M, Lally ET, Shattil SJ, Cunningham ME, Korchak HM. Early changes in cytosolic calcium and membrane potential induced by Actinobacillus actinomycetemcomitans leukotoxin in susceptible and resistant target cells. J Immunol. 1991 Nov 15; 147(10):3587-94. PMID: 1940358.
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    140. O'Toole TE, Mandelman D, Forsyth J, Shattil SJ, Plow EF, Ginsberg MH. Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science. 1991 Nov 08; 254(5033):845-7. PMID: 1948065.
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    141. Shattil SJ, Brugge JS. Protein tyrosine phosphorylation and the adhesive functions of platelets. Curr Opin Cell Biol. 1991 Oct; 3(5):869-79. PMID: 1931088.
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    142. Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shattil SJ. Platelet-derived microparticles express high affinity receptors for factor VIII. J Biol Chem. 1991 Sep 15; 266(26):17261-8. PMID: 1654328.
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    143. Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7844-8. PMID: 1715582.
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    144. Abrams C, Shattil SJ. Immunological detection of activated platelets in clinical disorders. Thromb Haemost. 1991 May 06; 65(5):467-73. PMID: 1871706.
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    145. Sims PJ, Ginsberg MH, Plow EF, Shattil SJ. Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J Biol Chem. 1991 Apr 25; 266(12):7345-52. PMID: 1902217.
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    146. Lages B, Shattil SJ, Bainton DF, Weiss HJ. Decreased content and surface expression of alpha-granule membrane protein GMP-140 in one of two types of platelet alpha delta storage pool deficiency. J Clin Invest. 1991 Mar; 87(3):919-29. PMID: 1705568.
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    147. George JN, Shattil SJ. The clinical importance of acquired abnormalities of platelet function. N Engl J Med. 1991 Jan 03; 324(1):27-39. PMID: 1984161.
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    148. Brass LF, Manning DR, Shattil SJ. GTP-binding proteins and platelet activation. Prog Hemost Thromb. 1991; 10:127-74. PMID: 1848944.
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    149. Shattil S. Use of monoclonal antibodies for the detection and analysis of activated human platelets. Curr Stud Hematol Blood Transfus. 1991; (58):26-31. PMID: 1954770.
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    150. Golden A, Brugge JS, Shattil SJ. Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins. J Cell Biol. 1990 Dec; 111(6 Pt 2):3117-27. PMID: 1702789.
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    151. Ginsberg MH, Frelinger AL, Lam SC, Forsyth J, McMillan R, Plow EF, Shattil SJ. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood. 1990 Nov 15; 76(10):2017-23. PMID: 2242424.
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    152. O'Toole TE, Loftus JC, Du XP, Glass AA, Ruggeri ZM, Shattil SJ, Plow EF, Ginsberg MH. Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul. 1990 Nov; 1(12):883-93. PMID: 2100193.
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    153. McCrae KR, Shattil SJ, Cines DB. Platelet activation induces increased Fc gamma receptor expression. J Immunol. 1990 May 15; 144(10):3920-7. PMID: 2139675.
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    154. Wiedmer T, Shattil SJ, Cunningham M, Sims PJ. Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor. Biochemistry. 1990 Jan 23; 29(3):623-32. PMID: 2159784.
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    155. Abrams CS, Ellison N, Budzynski AZ, Shattil SJ. Direct detection of activated platelets and platelet-derived microparticles in humans. Blood. 1990 Jan 01; 75(1):128-38. PMID: 2294986.
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    156. Sims PJ, Wiedmer T, Esmon CT, Weiss HJ, Shattil SJ. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity. J Biol Chem. 1989 Oct 15; 264(29):17049-57. PMID: 2793843.
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    157. Taub R, Gould RJ, Garsky VM, Ciccarone TM, Hoxie J, Friedman PA, Shattil SJ. A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J Biol Chem. 1989 Jan 05; 264(1):259-65. PMID: 2909518.
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    158. Brass LF, Shattil SJ. Interaction of extracellular calcium with the surface membrane of human platelets. Methods Enzymol. 1989; 169:355-71. PMID: 2654565.
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    159. Shattil SJ, Budzynski A, Scrutton MC. Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists. Blood. 1989 Jan; 73(1):150-8. PMID: 2535942.
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    160. Sims PJ, Faioni EM, Wiedmer T, Shattil SJ. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J Biol Chem. 1988 Dec 05; 263(34):18205-12. PMID: 2848029.
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    161. Bennett JS, Shattil SJ, Power JW, Gartner TK. Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex. J Biol Chem. 1988 Sep 15; 263(26):12948-53. PMID: 3417645.
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    162. Kowalski FV, Hale PD, Shattil SJ. Broadband continuous-wave laser. Opt Lett. 1988 Aug 01; 13(8):622. PMID: 19745983.
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    163. Brass LF, Shattil SJ. Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation. J Biol Chem. 1988 Apr 15; 263(11):5210-6. PMID: 2833498.
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    164. Shattil SJ. Expression, regulation and detection of fibrinogen receptors on activated human platelets. Prog Clin Biol Res. 1988; 283:345-80. PMID: 3062628.
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    165. Sigal SH, Cembrowski GS, Shattil SJ, Brown NM, Schifreen RS, Schwartz MW. Prototype quantitative assay for fibrinogen/fibrin degradation products. Clinical evaluation. Arch Intern Med. 1987 Oct; 147(10):1790-3. PMID: 3662708.
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    166. Shattil SJ, Cunningham M, Hoxie JA. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood. 1987 Jul; 70(1):307-15. PMID: 3297204.
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    167. Silberstein LE, Abrahm J, Shattil SJ. The efficacy of intensive plasma exchange in acquired von Willebrand's disease. Transfusion. 1987 May-Jun; 27(3):234-7. PMID: 3109084.
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    168. Shattil SJ, Brass LF. Induction of the fibrinogen receptor on human platelets by intracellular mediators. J Biol Chem. 1987 Jan 25; 262(3):992-1000. PMID: 3100533.
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    169. Shattil SJ, Motulsky HJ, Insel PA, Flaherty L, Brass LF. Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine. Blood. 1986 Dec; 68(6):1224-31. PMID: 3779100.
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    170. Motulsky HJ, Shattil SJ, Ferry N, Rozansky D, Insel PA. Desensitization of epinephrine-initiated platelet aggregation does not alter binding to the alpha 2-adrenergic receptor or receptor coupling to adenylate cyclase. Mol Pharmacol. 1986 Jan; 29(1):1-6. PMID: 2418346.
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    171. Shattil SJ, Hoxie JA, Cunningham M, Brass LF. Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. J Biol Chem. 1985 Sep 15; 260(20):11107-14. PMID: 2411729.
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    172. Brass LF, Shattil SJ, Kunicki TJ, Bennett JS. Effect of calcium on the stability of the platelet membrane glycoprotein IIb-IIIa complex. J Biol Chem. 1985 Jul 05; 260(13):7875-81. PMID: 2409078.
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    173. Shattil SJ, Brass LF, Bennett JS, Pandhi P. Biochemical and functional consequences of dissociation of the platelet membrane glycoprotein IIb-IIIa complex. Blood. 1985 Jul; 66(1):92-8. PMID: 3159447.
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    174. Shattil SJ, Brass LF. The interaction of extracellular calcium with the platelet membrane glycoprotein IIb-IIIa complex. Nouv Rev Fr Hematol. 1985; 27(4):211-7. PMID: 2997701.
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    175. Shattil SJ. Diagnosis and treatment of recurrent venous thromboembolism. Med Clin North Am. 1984 May; 68(3):577-600. PMID: 6379336.
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    176. Brass LF, Shattil SJ. Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets. J Clin Invest. 1984 Mar; 73(3):626-32. PMID: 6231306.
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    177. Shattil SJ, Brass LF. The prevention of prosthetic valve thromboembolism. Uses and limitations of anti-platelet drugs. Int J Cardiol. 1983 Apr; 3(1):87-91. PMID: 6852996.
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    178. Brass LF, Shattil SJ. Changes in surface-bound and exchangeable calcium during platelet activation. J Biol Chem. 1982 Dec 10; 257(23):14000-5. PMID: 7142191.
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    179. Shattil SJ, Montgomery JA, Chiang PK. The effect of pharmacologic inhibition of phospholipid methylation on human platelet function. Blood. 1982 May; 59(5):906-12. PMID: 7074219.
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    180. Barnathan ES, Addonizio VP, Shattil SJ. Interaction of verapamil with human platelet alpha-adrenergic receptors. Am J Physiol. 1982 Jan; 242(1):H19-23. PMID: 6277203.
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    181. Shattil SJ, McDonough M, Burch JW. Inhibition of platelet phospholipid methylation during platelet secretion. Blood. 1981 Mar; 57(3):537-44. PMID: 6779878.
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    182. Shattil SJ, Bennett JS. Platelets and their membranes in hemostasis: physiology and pathophysiology. Ann Intern Med. 1981 Jan; 94(1):108-18. PMID: 7004296.
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    183. Shattil SJ, McDonough M, Turnbull J, Insel PA. Characterization of alpha-adrenergic receptors in human platelets using [3H]clonidine. Mol Pharmacol. 1981 Jan; 19(1):179-83. PMID: 6259509.
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    184. Motulsky HJ, Shattil SJ, Insel PA. Characterization of alpha 2-adrenergic receptors on human platelets using [3H]yohimbine. Biochem Biophys Res Commun. 1980 Dec 31; 97(4):1562-70. PMID: 6260094.
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    185. Shattil SJ, Bennett JS, McDonough M, Turnbull J. Carbenicillin and penicillin G inhibit platelet function in vitro by impairing the interaction of agonists with the platelet surface. J Clin Invest. 1980 Feb; 65(2):329-37. PMID: 6243309.
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    186. Cooper RA, Shattil SJ. Membrane cholesterol--is enough too much? N Engl J Med. 1980 Jan 03; 302(1):49-51. PMID: 7350397.
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    187. Toaff ME, Strauss JF, Flickinger GL, Shattil SJ. Relationship of cholesterol supply to luteal mitochondrial steroid synthesis. J Biol Chem. 1979 May 25; 254(10):3977-82. PMID: 438171.
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    188. Toaff ME, Flickinger GL, Strauss JF, Shattil SJ. Relationships between cholesterol supply and luteal mitochondrial steroid synthesis. Adv Exp Med Biol. 1979; 112:541-3. PMID: 463628.
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    189. Insel PA, Nirenberg P, Turnbull J, Shattil SJ. Relationships between membrane cholesterol, alpha-adrenergic receptors, and platelet function. Biochemistry. 1978 Nov 28; 17(24):5269-74. PMID: 215196.
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    190. Kaywin P, McDonough M, Insel PA, Shattil SJ. Platelet function in essential thrombocythemia. Decreased epinephrine responsiveness associated with a deficiency of platelet alpha-adrenergic receptors. N Engl J Med. 1978 Sep 07; 299(10):505-9. PMID: 210377.
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    191. Shattil SJ, Cines DB, Schreiber AD. Increased fluidity of human platelet membranes during complement-mediated immune platelet injury. J Clin Invest. 1978 Mar; 61(3):582-9. PMID: 641139.
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    192. Cooper RA, Leslie MH, Fischkoff S, Shinitzky M, Shattil SJ. Factors influencing the lipid composition and fluidity of red cell membranes in vitro: production of red cells possessing more than two cholesterols per phospholipid. Biochemistry. 1978 Jan 24; 17(2):327-31. PMID: 619993.
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    193. Shattil SJ, Cooper RA. Role of membrane lipid composition, organization, and fluidity in human platelet function. Prog Hemost Thromb. 1978; 4:59-86. PMID: 362482.
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    194. Sinha AK, Shattil SJ, Colman RW. Cyclic AMP metabolism in cholesterol-rich platelets. J Biol Chem. 1977 May 25; 252(10):3310-4. PMID: 193833.
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    195. Shattil SJ, Bennett JS, Colman RW, Cooper RA. Abnormalities of cholesterol-phospholipid composition in platelets and low-density lipoproteins of human hyperbetalipoproteinemia. J Lab Clin Med. 1977 Feb; 89(2):341-53. PMID: 188956.
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    196. Shattil SJ, Cooper RA. Membrane microviscosity and human platelet function. Biochemistry. 1976 Nov 02; 15(22):4832-7. PMID: 990246.
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    197. Colman RW, Bennett JS, Sheridan JF, Cooper RA, Shattil SJ. Halofenate: a potent inhibitor of normal and hypersensitive platelets. J Lab Clin Med. 1976 Aug; 88(2):282-91. PMID: 956686.
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    198. Anaya-Galindo R, Shattil SJ, Shelburne JC, Colman RW. Soluble fibrin complexes in coronary disease. Thromb Res. 1976 Aug; 9(2):153-65. PMID: 788221.
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    199. Shattil SJ, Anaya-Galindo R, Bennett J, Colman RW, Cooper RA. Platelet hypersensitivity induced by cholesterol incorporation. J Clin Invest. 1975 Mar; 55(3):636-43. PMID: 1117069.
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    200. Cooper RA, Arner EC, Wiley JS, Shattil SJ. Modification of red cell membrane structure by cholesterol-rich lipid dispersions. A model for the primary spur cell defect. J Clin Invest. 1975 Jan; 55(1):115-26. PMID: 162782.
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    201. Morse BM, Shattil SJ. Metabolic complications of aggressive therapy of chronic lymphocytic leukemia. Am J Med Sci. 1974 May; 267(5):311-4. PMID: 4833837.
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    202. Abramson N, Shattil SJ. M-components. JAMA. 1973 Jan 08; 223(2):156-9. PMID: 4631886.
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    203. Shattil SJ, Cooper RA. Maturation of macroreticulocyte membranes in vivo. J Lab Clin Med. 1972 Feb; 79(2):215-27. PMID: 5009711.
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    204. Cooper RA, Shattil SJ. Mechanisms of hemolysis--the minimal red-cell defect. N Engl J Med. 1971 Dec 30; 285(27):1514-20. PMID: 4942489.
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    205. Cooper RA, Shattil SJ. The red cell membrane in hemolytic anemia. Mod Treat. 1971 May; 8(2):329-51. PMID: 4940517.
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