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    Peter Shaw

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0946
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      HTRA1 as a Therapeutic Target in the Treatment of Wet AMD
      NIH/NEI R01EY025693Aug 1, 2015 - Jun 30, 2020
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Apara A, Galvao J, Wang Y, Blackmore M, Trillo A, Iwao K, Brown DP, Fernandes KA, Huang A, Nguyen T, Ashouri M, Zhang X, Shaw P, Kunzevitzky NJ, Moore DL, Libby RT, Goldberg JL. KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS. J Neurosci. 2017 Sep 04. PMID: 28871032.
        View in: PubMed
      2. Shaw P, Fang J, Sang A, Wang Y, Kapiloff MS, Goldberg JL. Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. Invest Ophthalmol Vis Sci. 2016 Sep 01; 57(11):5083-5092. PMID: 27679853.
        View in: PubMed
      3. Shaw P, Sang A, Wang Y, Ho D, Douglas C, Dia L, Goldberg JL. Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury. Exp Eye Res. 2016 Jul 18. PMID: 27443501.
        View in: PubMed
      4. Shaw P, Stiles T, Douglas C, Ho D, Fan W, Du H, Xiao X. Oxidative stress, innate immunity, and age-related macular degeneration. AIMS Mol Sci. 2016; 3(2):196-221. PMID: 27239555.
        View in: PubMed
      5. Fang J, Shaw P, Wang Y, Goldberg JL. Krüppel-Like Factor 4 (KLF4) Is Not Required for Retinal Cell Differentiation. eNeuro. 2016 Jan-Feb; 3(1). PMID: 27022622; PMCID: PMC4770008.
      6. Du H, Xiao X, Stiles T, Douglas C, Ho D, Shaw P. Novel Mechanistic Interplay between Products of Oxidative Stress and Components of the Complement System in AMD Pathogenesis. Open J Ophthalmol. 2016 Feb; 6(1):43-50. PMID: 27668132.
        View in: PubMed
      7. Shaw P, Werstuck G, Chen Y. Oxidative stress and aging diseases. Oxid Med Cell Longev. 2014; 2014:569146. PMID: 24959310; PMCID: PMC4052780.
      8. Xiao X, Du HJ, Hu WJ, Shaw P. The influence of long term hydrochlorothiazide administration on the relationship between renin-angiotensin-aldosterone system activity and plasma glucose in patients with hypertension. Oxid Med Cell Longev. 2013; 2013:434618. PMID: 24349612; PMCID: PMC3852583.
      9. Luo J, Zhao L, Chen AY, Zhang X, Zhu J, Zhao J, Ouyang H, Luo H, Song Y, Lee J, Patel SH, Shaw P, Sadda S, Zhuo Y, Rosenfeld MG, Zhang K. TCF7L2 variation and proliferative diabetic retinopathy. Diabetes. 2013 Jul; 62(7):2613-7. PMID: 23434931; PMCID: PMC3712060.
      10. Lee J, Zeng J, Hughes G, Chen Y, Grob S, Zhao L, Lee C, Krupa M, Quach J, Luo J, Zeng J, Wei X, Zhang X, Zhu J, Duan Y, Ferreyra H, Goldbaum M, Haw W, Shaw P, Tang L, Zhang K. Association of LIPC and advanced age-related macular degeneration. Eye (Lond). 2013 Feb; 27(2):265-70; quiz 271. PMID: 23348725; PMCID: PMC3574263.
      11. Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw P, Karin M, Zhang K. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82. PMID: 23341606; PMCID: PMC3568328.
      12. Shaw P, Zhang L, Zhang M, Du H, Zhao L, Lee C, Grob S, Lim SL, Hughes G, Lee J, Bedell M, Nelson MH, Lu F, Krupa M, Luo J, Ouyang H, Tu Z, Su Z, Zhu J, Wei X, Feng Z, Duan Y, Yang Z, Ferreyra H, Bartsch DU, Kozak I, Zhang L, Lin F, Sun H, Feng H, Zhang K. Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13757-62. PMID: 22875704; PMCID: PMC3427125.
      13. Zhao L, Grob S, Corey R, Krupa M, Luo J, Du H, Lee C, Hughes G, Lee J, Quach J, Zhu J, Shaw P, Kozak I, Zhang K. A novel compound heterozygous mutation in the BEST1 gene causes autosomal recessive Best vitelliform macular dystrophy. Eye (Lond). 2012 Jun; 26(6):866-71. PMID: 22422030; PMCID: PMC3376281.
      14. Zhang L, Lim SL, Du H, Zhang M, Kozak I, Hannum G, Wang X, Ouyang H, Hughes G, Zhao L, Zhu X, Lee C, Su Z, Zhou X, Shaw R, Geum D, Wei X, Zhu J, Ideker T, Oka C, Wang N, Yang Z, Shaw P, Zhang K. High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-ß family member growth differentiation factor 6. J Biol Chem. 2012 Jan 06; 287(2):1520-6. PMID: 22049084; PMCID: PMC3256864.
      15. Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw P, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27. PMID: 21982317; PMCID: PMC3230644.
      16. Sommer JR, Estrada JL, Collins EB, Bedell M, Alexander CA, Yang Z, Hughes G, Mir B, Gilger BC, Grob S, Wei X, Piedrahita JA, Shaw P, Petters RM, Zhang K. Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration. Br J Ophthalmol. 2011 Dec; 95(12):1749-54. PMID: 21873315.
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      17. Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw P, Tsimikas S, Binder CJ, Witztum JL. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21; 108(2):235-48. PMID: 21252151; PMCID: PMC3075542.
      18. Zhang K, Harada Y, Wei X, Shukla D, Rajendran A, Tawansy K, Bedell M, Lim S, Shaw P, He X, Yang Z. An essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy. J Biol Chem. 2011 Mar 25; 286(12):10210-5. PMID: 21177847; PMCID: PMC3060474.
      19. Briley-Saebo KC, Cho YS, Shaw P, Ryu SK, Mani V, Dickson S, Izadmehr E, Green S, Fayad ZA, Tsimikas S. Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopes. J Am Coll Cardiol. 2011 Jan 18; 57(3):337-47. PMID: 21106318; PMCID: PMC3095034.
      20. Wool GD, Cabana VG, Lukens J, Shaw P, Binder CJ, Witztum JL, Reardon CA, Getz GS. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. FASEB J. 2011 Jan; 25(1):290-300. PMID: 20876212; PMCID: PMC3005429.
      21. Wang X, Harmon J, Zabrieskie N, Chen Y, Grob S, Williams B, Lee C, Kasuga D, Shaw P, Buehler J, Wang N, Zhang K. Using the Utah Population Database to assess familial risk of primary open angle glaucoma. Vision Res. 2010 Nov 23; 50(23):2391-5. PMID: 20858511.
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      22. Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw P, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May; 119(5):1335-49. PMID: 19363291; PMCID: PMC2673862.
      23. Hartvigsen K, Chou MY, Hansen LF, Shaw P, Tsimikas S, Binder CJ, Witztum JL. The role of innate immunity in atherogenesis. J Lipid Res. 2009 Apr; 50 Suppl:S388-93. PMID: 19106070; PMCID: PMC2674727.
      24. Briley-Saebo KC, Shaw P, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008 Jun 24; 117(25):3206-15. PMID: 18541740; PMCID: PMC4492476.
      25. Chou MY, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw P, Boullier A, Binder CJ, Witztum JL. Oxidation-specific epitopes are important targets of innate immunity. J Intern Med. 2008 May; 263(5):479-88. PMID: 18410591.
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      26. Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw P, Boullier A, Witztum JL. Natural antibodies in murine atherosclerosis. Curr Drug Targets. 2008 Mar; 9(3):190-5. PMID: 18336236.
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      27. Choi SH, Chae A, Chen CH, Merki E, Shaw P, Tsimikas S. Emerging approaches for imaging vulnerable plaques in patients. Curr Opin Biotechnol. 2007 Feb; 18(1):73-82. PMID: 17234398.
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      28. Binder CJ, Shaw P, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum JL. The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul; 46(7):1353-63. PMID: 15897601.
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      29. Chen Z, Mi L, Xu J, Yu J, Wang X, Jiang J, Xing J, Shang P, Qian A, Li Y, Shaw P, Wang J, Duan S, Ding J, Fan C, Zhang Y, Yang Y, Yu X, Feng Q, Li B, Yao X, Zhang Z, Li L, Xue X, Zhu P. Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. J Infect Dis. 2005 Mar 01; 191(5):755-60. PMID: 15688292.
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      30. Torzewski M, Shaw P, Han KR, Shortal B, Lackner KJ, Witztum JL, Palinski W, Tsimikas S. Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol. 2004 Dec; 24(12):2307-12. PMID: 15528482.
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      31. Shaw P. Rethinking oxidized low-density lipoprotein, its role in atherogenesis and the immune responses associated with it. Arch Immunol Ther Exp (Warsz). 2004 Jul-Aug; 52(4):225-39. PMID: 15467487.
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      32. Miller YI, Chang MK, Binder CJ, Shaw P, Witztum JL. Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol. 2003 Oct; 14(5):437-45. PMID: 14501582.
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      33. Shaw P, Goodyear CS, Chang MK, Witztum JL, Silverman GJ. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells. J Immunol. 2003 Jun 15; 170(12):6151-7. PMID: 12794145.
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      34. Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw P, Palinski W, Witztum JL, Silverman GJ. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003 Jun; 9(6):736-43. PMID: 12740573.
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      35. Binder CJ, Chang MK, Shaw P, Miller YI, Hartvigsen K, Dewan A, Witztum JL. Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov; 8(11):1218-26. PMID: 12411948.
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      36. Tsimikas S, Shaw P. Non-invasive imaging of vulnerable plaques by molecular targeting of oxidized LDL with tagged oxidation-specific antibodies. J Cell Biochem Suppl. 2002; 39:138-46. PMID: 12552613.
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      37. Boullier A, Bird DA, Chang MK, Dennis EA, Friedman P, Gillotre-Taylor K, Hörkkö S, Palinski W, Quehenberger O, Shaw P, Steinberg D, Terpstra V, Witztum JL. Scavenger receptors, oxidized LDL, and atherosclerosis. Ann N Y Acad Sci. 2001 Dec; 947:214-22; discussion 222-3. PMID: 11795269.
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      38. Shaw P, Hörkkö S, Tsimikas S, Chang MK, Palinski W, Silverman GJ, Chen PP, Witztum JL. Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo. Arterioscler Thromb Vasc Biol. 2001 Aug; 21(8):1333-9. PMID: 11498462.
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      39. Hörkkö S, Binder CJ, Shaw P, Chang MK, Silverman G, Palinski W, Witztum JL. Immunological responses to oxidized LDL. Free Radic Biol Med. 2000 Jun 15; 28(12):1771-9. PMID: 10946219.
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      40. Shaw P, Hörkkö S, Chang MK, Curtiss LK, Palinski W, Silverman GJ, Witztum JL. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J Clin Invest. 2000 Jun; 105(12):1731-40. PMID: 10862788; PMCID: PMC378505.
      41. Silverman GJ, Shaw P, Luo L, Dwyer D, Chang M, Horkko S, Palinski W, Stall A, Witztum JL. Neo-self antigens and the expansion of B-1 cells: lessons from atherosclerosis-prone mice. Curr Top Microbiol Immunol. 2000; 252:189-200. PMID: 11125476.
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