Peter Shaw

Title(s)Associate Adjunct Professor, Ophthalmology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    HTRA1 as a Therapeutic Target in the Treatment of Wet AMD
    NIH R01EY025693Aug 1, 2015 - Jun 30, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Oxidative stress and antioxidants in cataract development. Curr Opin Ophthalmol. 2024 Jan 01; 35(1):57-63. Lee B, Afshari NA, Shaw PX. PMID: 37882550.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. The Effect of Anti-Inflammatory Topical Ophthalmic Treatments on In Vitro Corneal Epithelial Cells. Transl Vis Sci Technol. 2022 09 01; 11(9):16. Sella R, Cohen-Tayar Y, Noguchi T, Finburgh EN, Lian RR, Abbas AA, Hakim DF, Bu JJ, Zhao J, Shaw P, Bahar I, Afshari NA. PMID: 36129699; PMCID: PMC9513739.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degeneration. Exp Eye Res. 2021 09; 210:108605. May A, Su F, Dinh B, Ehlen R, Tran C, Adivikolanu H, Shaw PX. PMID: 33930395.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. The interplay of oxidative stress and ARMS2-HTRA1 genetic risk in neovascular AMD. Vessel Plus. 2021; 5. Lu ZG, May A, Dinh B, Lin V, Su F, Tran C, Adivikolanu H, Ehlen R, Che B, Wang ZH, Shaw DH, Borooah S, Shaw PX. PMID: 34017939; PMCID: PMC8133762.
      View in: PubMed   Mentions: 6  
    5. Late-onset retinal degeneration pathology due to mutations in CTRP5 is mediated through HTRA1. Aging Cell. 2019 12; 18(6):e13011. Chekuri A, Zientara-Rytter K, Soto-Hermida A, Borooah S, Voronchikhina M, Biswas P, Kumar V, Goodsell D, Hayward C, Shaw P, Stanton C, Garland D, Subramani S, Ayyagari R. PMID: 31385385; PMCID: PMC6826137.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    6. HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression. PLoS One. 2019; 14(5):e0216808. Lu Z, Lin V, May A, Che B, Xiao X, Shaw DH, Su F, Wang Z, Du H, Shaw PX. PMID: 31100080; PMCID: PMC6524793.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    7. Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis. Genet Med. 2019 10; 21(10):2345-2354. Gong B, Zhang H, Huang L, Chen Y, Shi Y, Tam PO, Zhu X, Huang Y, Lei B, Sundaresan P, Li X, Jiang L, Yang J, Lin Y, Lu F, Chen L, Li Y, Leung CK, Guo X, Zhang S, Huang G, Wu Y, Zhou T, Shuai P, Tham CC, Weisschuh N, Krishnadas SR, Mardin C, Reis A, Yang J, Zhang L, Zhou Y, Wang Z, Qu C, Shaw PX, Pang CP, Sun X, Zhu W, Li DY, Pasutto F, Yang Z. PMID: 31000793.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    8. MicroRNA miR-24-3p Reduces Apoptosis and Regulates Keap1-Nrf2 Pathway in Mouse Cardiomyocytes Responding to Ischemia/Reperfusion Injury. Oxid Med Cell Longev. 2018; 2018:7042105. Xiao X, Lu Z, Lin V, May A, Shaw DH, Wang Z, Che B, Tran K, Du H, Shaw PX. PMID: 30622671; PMCID: PMC6304907.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    9. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Sci Signal. 2018 02 13; 11(517). Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. PMID: 29440509; PMCID: PMC5957084.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    10. Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation. Oxid Med Cell Longev. 2017; 2017:1284804. Xiao X, Hou H, Lin V, Ho D, Tran K, Che B, May A, Zhang J, Lu Z, Lu Z, Shaw PX. PMID: 29213348; PMCID: PMC5682903.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    11. KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS. J Neurosci. 2017 10 04; 37(40):9632-9644. Apara A, Galvao J, Wang Y, Blackmore M, Trillo A, Iwao K, Brown DP, Fernandes KA, Huang A, Nguyen T, Ashouri M, Zhang X, Shaw PX, Kunzevitzky NJ, Moore DL, Libby RT, Goldberg JL. PMID: 28871032; PMCID: PMC5628408.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    12. Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. Invest Ophthalmol Vis Sci. 2016 Sep 01; 57(11):5083-5092. Shaw PX, Fang J, Sang A, Wang Y, Kapiloff MS, Goldberg JL. PMID: 27679853; PMCID: PMC5053116.
      View in: PubMed   Mentions: 4     Fields:    
    13. Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury. Exp Eye Res. 2017 05; 158:33-42. Shaw PX, Sang A, Wang Y, Ho D, Douglas C, Dia L, Goldberg JL. PMID: 27443501; PMCID: PMC5821900.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    14. Oxidative stress, innate immunity, and age-related macular degeneration. AIMS Mol Sci. 2016; 3(2):196-221. Shaw PX, Stiles T, Douglas C, Ho D, Fan W, Du H, Xiao X. PMID: 27239555; PMCID: PMC4882104.
      View in: PubMed   Mentions: 80  
    15. Krüppel-Like Factor 4 (KLF4) Is Not Required for Retinal Cell Differentiation. eNeuro. 2016 Jan-Feb; 3(1). Fang J, Shaw PX, Wang Y, Goldberg JL. PMID: 27022622; PMCID: PMC4770008.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Novel Mechanistic Interplay between Products of Oxidative Stress and Components of the Complement System in AMD Pathogenesis. Open J Ophthalmol. 2016 Feb; 6(1):43-50. Du H, Xiao X, Stiles T, Douglas C, Ho D, Shaw PX. PMID: 27668132; PMCID: PMC5035113.
      View in: PubMed   Mentions: 8  
    17. Oxidative stress and aging diseases. Oxid Med Cell Longev. 2014; 2014:569146. Shaw PX, Werstuck G, Chen Y. PMID: 24959310; PMCID: PMC4052780.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    18. Human retinal progenitor cell transplantation preserves vision. J Biol Chem. 2014 Mar 07; 289(10):6362-6371. Luo J, Baranov P, Patel S, Ouyang H, Quach J, Wu F, Qiu A, Luo H, Hicks C, Zeng J, Zhu J, Lu J, Sfeir N, Wen C, Zhang M, Reade V, Patel S, Sinden J, Sun X, Shaw P, Young M, Zhang K. PMID: 24407289; PMCID: PMC3945303.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    19. The influence of long term hydrochlorothiazide administration on the relationship between renin-angiotensin-aldosterone system activity and plasma glucose in patients with hypertension. Oxid Med Cell Longev. 2013; 2013:434618. Xiao X, Du HJ, Hu WJ, Shaw PX. PMID: 24349612; PMCID: PMC3852583.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    20. TCF7L2 variation and proliferative diabetic retinopathy. Diabetes. 2013 Jul; 62(7):2613-7. Luo J, Zhao L, Chen AY, Zhang X, Zhu J, Zhao J, Ouyang H, Luo H, Song Y, Lee J, Patel SH, Shaw PX, Sadda S, Zhuo Y, Rosenfeld MG, Zhang K. PMID: 23434931; PMCID: PMC3712060.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    21. Association of LIPC and advanced age-related macular degeneration. Eye (Lond). 2013 Feb; 27(2):265-70; quiz 271. Lee J, Zeng J, Hughes G, Chen Y, Grob S, Zhao L, Lee C, Krupa M, Quach J, Luo J, Zeng J, Wei X, Zhang X, Zhu J, Duan Y, Ferreyra H, Goldbaum M, Haw W, Shaw PX, Tang L, Zhang K. PMID: 23348725; PMCID: PMC3574263.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    22. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82. Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. PMID: 23341606; PMCID: PMC3568328.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    23. Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13757-62. Shaw PX, Zhang L, Zhang M, Du H, Zhao L, Lee C, Grob S, Lim SL, Hughes G, Lee J, Bedell M, Nelson MH, Lu F, Krupa M, Luo J, Ouyang H, Tu Z, Su Z, Zhu J, Wei X, Feng Z, Duan Y, Yang Z, Ferreyra H, Bartsch DU, Kozak I, Zhang L, Lin F, Sun H, Feng H, Zhang K. PMID: 22875704; PMCID: PMC3427125.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    24. A novel compound heterozygous mutation in the BEST1 gene causes autosomal recessive Best vitelliform macular dystrophy. Eye (Lond). 2012 Jun; 26(6):866-71. Zhao L, Grob S, Corey R, Krupa M, Luo J, Du H, Lee C, Hughes G, Lee J, Quach J, Zhu J, Shaw PX, Kozak I, Zhang K. PMID: 22422030; PMCID: PMC3376281.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6. J Biol Chem. 2012 Jan 06; 287(2):1520-6. Zhang L, Lim SL, Du H, Zhang M, Kozak I, Hannum G, Wang X, Ouyang H, Hughes G, Zhao L, Zhu X, Lee C, Su Z, Zhou X, Shaw R, Geum D, Wei X, Zhu J, Ideker T, Oka C, Wang N, Yang Z, Shaw PX, Zhang K. PMID: 22049084; PMCID: PMC3256864.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    26. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27. Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. PMID: 21982317; PMCID: PMC3230644.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    27. Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration. Br J Ophthalmol. 2011 Dec; 95(12):1749-54. Sommer JR, Estrada JL, Collins EB, Bedell M, Alexander CA, Yang Z, Hughes G, Mir B, Gilger BC, Grob S, Wei X, Piedrahita JA, Shaw PX, Petters RM, Zhang K. PMID: 21873315.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    28. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21; 108(2):235-48. Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. PMID: 21252151; PMCID: PMC3075542.
      View in: PubMed   Mentions: 306     Fields:    Translation:HumansAnimalsCells
    29. An essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy. J Biol Chem. 2011 Mar 25; 286(12):10210-5. Zhang K, Harada Y, Wei X, Shukla D, Rajendran A, Tawansy K, Bedell M, Lim S, Shaw PX, He X, Yang Z. PMID: 21177847; PMCID: PMC3060474.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    30. Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopes. J Am Coll Cardiol. 2011 Jan 18; 57(3):337-47. Briley-Saebo KC, Cho YS, Shaw PX, Ryu SK, Mani V, Dickson S, Izadmehr E, Green S, Fayad ZA, Tsimikas S. PMID: 21106318; PMCID: PMC3095034.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    31. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. FASEB J. 2011 Jan; 25(1):290-300. Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum JL, Reardon CA, Getz GS. PMID: 20876212; PMCID: PMC3005429.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    32. Using the Utah Population Database to assess familial risk of primary open angle glaucoma. Vision Res. 2010 Nov 23; 50(23):2391-5. Wang X, Harmon J, Zabrieskie N, Chen Y, Grob S, Williams B, Lee C, Kasuga D, Shaw PX, Buehler J, Wang N, Zhang K. PMID: 20858511.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    33. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May; 119(5):1335-49. Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. PMID: 19363291; PMCID: PMC2673862.
      View in: PubMed   Mentions: 244     Fields:    Translation:AnimalsCells
    34. The role of innate immunity in atherogenesis. J Lipid Res. 2009 Apr; 50 Suppl:S388-93. Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. PMID: 19106070; PMCID: PMC2674727.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    35. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008 Jun 24; 117(25):3206-15. Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA. PMID: 18541740; PMCID: PMC4492476.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    36. Oxidation-specific epitopes are important targets of innate immunity. J Intern Med. 2008 May; 263(5):479-88. Chou MY, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw PX, Boullier A, Binder CJ, Witztum JL. PMID: 18410591.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    37. Natural antibodies in murine atherosclerosis. Curr Drug Targets. 2008 Mar; 9(3):190-5. Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum JL. PMID: 18336236.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    38. Emerging approaches for imaging vulnerable plaques in patients. Curr Opin Biotechnol. 2007 Feb; 18(1):73-82. Choi SH, Chae A, Chen CH, Merki E, Shaw PX, Tsimikas S. PMID: 17234398.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul; 46(7):1353-63. Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum JL. PMID: 15897601.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    40. Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. J Infect Dis. 2005 Mar 01; 191(5):755-60. Chen Z, Mi L, Xu J, Yu J, Wang X, Jiang J, Xing J, Shang P, Qian A, Li Y, Shaw PX, Wang J, Duan S, Ding J, Fan C, Zhang Y, Yang Y, Yu X, Feng Q, Li B, Yao X, Zhang Z, Li L, Xue X, Zhu P. PMID: 15688292; PMCID: PMC7110046.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
    41. Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol. 2004 Dec; 24(12):2307-12. Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum JL, Palinski W, Tsimikas S. PMID: 15528482.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    42. Rethinking oxidized low-density lipoprotein, its role in atherogenesis and the immune responses associated with it. Arch Immunol Ther Exp (Warsz). 2004 Jul-Aug; 52(4):225-39. Shaw PX. PMID: 15467487.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    43. Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol. 2003 Oct; 14(5):437-45. Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum JL. PMID: 14501582.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    44. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells. J Immunol. 2003 Jun 15; 170(12):6151-7. Shaw PX, Goodyear CS, Chang MK, Witztum JL, Silverman GJ. PMID: 12794145.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    45. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003 Jun; 9(6):736-43. Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum JL, Silverman GJ. PMID: 12740573.
      View in: PubMed   Mentions: 276     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    46. Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov; 8(11):1218-26. Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum JL. PMID: 12411948.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    47. Non-invasive imaging of vulnerable plaques by molecular targeting of oxidized LDL with tagged oxidation-specific antibodies. J Cell Biochem Suppl. 2002; 39:138-46. Tsimikas S, Shaw PX. PMID: 12552613.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    48. Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo. Arterioscler Thromb Vasc Biol. 2001 Aug; 21(8):1333-9. Shaw PX, Hörkkö S, Tsimikas S, Chang MK, Palinski W, Silverman GJ, Chen PP, Witztum JL. PMID: 11498462.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    49. Immunological responses to oxidized LDL. Free Radic Biol Med. 2000 Jun 15; 28(12):1771-9. Hörkkö S, Binder CJ, Shaw PX, Chang MK, Silverman G, Palinski W, Witztum JL. PMID: 10946219.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    50. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J Clin Invest. 2000 Jun; 105(12):1731-40. Shaw PX, Hörkkö S, Chang MK, Curtiss LK, Palinski W, Silverman GJ, Witztum JL. PMID: 10862788; PMCID: PMC378505.
      View in: PubMed   Mentions: 264     Fields:    Translation:AnimalsCells
    51. Neo-self antigens and the expansion of B-1 cells: lessons from atherosclerosis-prone mice. Curr Top Microbiol Immunol. 2000; 252:189-200. Silverman GJ, Shaw PX, Luo L, Dwyer D, Chang M, Horkko S, Palinski W, Stall A, Witztum JL. PMID: 11125476.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells