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Richard Klemke

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0612
La Jolla CA 92093
Phone8/8-22--5610
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of a Novel Therapeutic Transporter to Treat Metastatic Cancers
    NIH/NCI R41CA257020Sep 1, 2020 - Aug 31, 2021
    Role: Principal Investigator
    Development of CA-IL-12 for Triple Negative Breast Cancer
    NIH/NCI R41CA250887Jun 15, 2020 - May 31, 2021
    Role: Principal Investigator
    Fingerprinting Invasive Membrane Protrusions to Discover Metastatic Signatures
    NIH/NCI R01CA182495Sep 1, 2014 - Mar 31, 2020
    Role: Principal Investigator
    Vascular communication in metastatic brain colonization
    NIH/NCI R01CA184594Apr 3, 2014 - Feb 28, 2019
    Role: Principal Investigator
    Pre-clinical development of a novel pancreatic cancer chemotherapeutic
    NIH/NCI R43CA180398Sep 1, 2013 - Aug 31, 2014
    Role: Principal Investigator
    Imagining Human Cancer Progression in a Novel Zebrafish Model
    NIH/NCI R01CA129231Aug 1, 2008 - May 31, 2013
    Role: Principal Investigator
    A Proteomics Research Resource for Integrative Biology
    NIH P41RR018522Sep 15, 2003 - Jun 30, 2013
    Role: Co-Investigator
    Mechanisms of Lamellipodia Growth and Retraction
    NIH/NIGMS R01GM068487Aug 1, 2003 - Jul 31, 2012
    Role: Principal Investigator
    Survival Mechanisms of Invasive Carcinoma Cells
    NIH/NCI R01CA097022Apr 1, 2003 - Mar 31, 2008
    Role: Principal Investigator
    Cell Migration Consortium
    NIH U54GM064346Sep 15, 2001 - Jul 31, 2014
    Role: Co-Investigator
    SIGNALING MECHANISMS OF CELL MOTILITY &TUMOR METASTASIS
    NIH/NCI R29CA078493Aug 1, 1998 - Jul 31, 2003
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    MOLECULAR BASIS OF INTEGRIN MEDIATED CELL MIGRATION
    NIH/NCI F32CA067442Mar 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transplantation of Human-Induced Pluripotent Stem Cell-Derived Neural Precursors into Early-Stage Zebrafish Embryos. J Mol Neurosci. 2018 Jul; 65(3):351-358. Strnadel J, Wang H, Carromeu C, Miyanohara A, Fujimura K, Blahovcova E, Nosal V, Skovierova H, Klemke R, Halasova E. PMID: 30003430.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discov. 2018; 4:26. Wang H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, Zhang W, Watson F, Yu V, Liu C, Melo CM, Miller YI, Elliott KC, Cheresh DA, Klemke RL. PMID: 29872538.
      View in: PubMed   Mentions:
    3. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun. 2018 04 03; 9(1):1310. Liu C, Han T, Stachura DL, Wang H, Vaisman BL, Kim J, Klemke RL, Remaley AT, Rana TM, Traver D, Miller YI. PMID: 29615667.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018 02 14; 8(1):2982. Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, Klemke RL, Mantuano E, Gonias SL. PMID: 29445239.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma. Exp Cell Res. 2018 02 15; 363(2):271-282. Noriega-Guerra H, Cruz MC, Ribeiro PRL, Strnadel J, Wang H, Klemke RL, Jaeger RG, Freitas VM. PMID: 29355494.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop. Cancer Res. 2018 03 15; 78(6):1444-1456. Fujimura K, Wang H, Watson F, Klemke RL. PMID: 29321164.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 04 15; 77(8):1997-2007. Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL. PMID: 28381547.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    8. Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels. J Biol Chem. 2015 Dec 11; 290(50):29907-19. Fujimura K, Choi S, Wyse M, Strnadel J, Wright T, Klemke R. PMID: 26483550.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    9. PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFß Responses in Breast Cancer. PLoS One. 2015; 10(8):e0135748. Agajanian M, Campeau A, Hoover M, Hou A, Brambilla D, Kim SL, Klemke RL, Kelber JA. PMID: 26267863.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    10. A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Res. 2014 Nov 15; 74(22):6671-81. Fujimura K, Wright T, Strnadel J, Kaushal S, Metildi C, Lowy AM, Bouvet M, Kelber JA, Klemke RL. PMID: 25261239.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    11. Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics. 2015 Jan; 14(1):1-14. Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR, Klemke R, Gonias SL, Coppinger JA. PMID: 24997994.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    12. CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports. 2014 Apr 08; 2(4):427-39. Spike BT, Kelber JA, Booker E, Kalathur M, Rodewald R, Lipianskaya J, La J, He M, Wright T, Klemke R, Wahl GM, Gray PC. PMID: 24749068.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    13. [Data protection in rehabilitation research]. Rehabilitation (Stuttg). 2014 Aug; 53(4):258-67. Exner AK, Gerold H, Breckenkamp J, Bahmer J, Klemke R, Berg-Beckhoff G, Horschke A, Razum O. PMID: 24363217.
      View in: PubMed   Mentions:    Fields:    
    14. Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome. Anal Biochem. 2014 Feb 01; 446:102-7. Choi S, Kelber J, Jiang X, Strnadel J, Fujimura K, Pasillas M, Coppinger J, Klemke R. PMID: 24161902.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. Role of connexins in metastatic breast cancer and melanoma brain colonization. J Cell Sci. 2013 Feb 15; 126(Pt 4):904-13. Stoletov K, Strnadel J, Zardouzian E, Momiyama M, Park FD, Kelber JA, Pizzo DP, Hoffman R, VandenBerg SR, Klemke RL. PMID: 23321642.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    16. Proteomic and biochemical methods to study the cytoskeletome. Methods Mol Biol. 2013; 1046:203-18. Klemke RL, Jiang X, Choi S, Kelber JA. PMID: 23868590.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem. 2013 Jan 04; 288(1):123-31. Bristow JM, Reno TA, Jo M, Gonias SL, Klemke RL. PMID: 23105102.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    18. Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits. Curr Opin Cell Biol. 2012 Oct; 24(5):662-9. Klemke RL. PMID: 22980730.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    19. Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness. Biomaterials. 2012 Oct; 33(29):7064-70. Soman P, Kelber JA, Lee JW, Wright TN, Vecchio KS, Klemke RL, Chen S. PMID: 22809641.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    20. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res. 2012 May 15; 72(10):2554-64. Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke RL. PMID: 22589274.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    21. Proteomics method for identification of pseudopodium phosphotyrosine proteins. Methods Mol Biol. 2012; 757:349-65. Wang Y, Klemke RL. PMID: 21909922.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells. Proteomics. 2011 May; 11(10):2019-26. Wang Y, Yang F, Gritsenko MA, Wang Y, Clauss T, Liu T, Shen Y, Monroe ME, Lopez-Ferrer D, Reno T, Moore RJ, Klemke RL, Camp DG, Smith RD. PMID: 21500348.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCells
    23. Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem. 2011 May 20; 286(20):18190-201. Wang Y, Yang F, Fu Y, Huang X, Wang W, Jiang X, Gritsenko MA, Zhao R, Monore ME, Pertz OC, Purvine SO, Orton DJ, Jacobs JM, Camp DG, Smith RD, Klemke RL. PMID: 21454597.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res. 2010 Nov 01; 70(21):8948-58. Jo M, Eastman BM, Webb DL, Stoletov K, Klemke R, Gonias SL. PMID: 20940399.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    25. A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood. 2010 Dec 16; 116(25):5773-83. Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA. PMID: 20826718.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. PEAK1, a novel kinase target in the fight against cancer. Oncotarget. 2010 Jul; 1(3):219-23. Kelber JA, Klemke RL. PMID: 21301050.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    27. Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci. 2010 Jul 01; 123(Pt 13):2332-41. Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S, Klemke R. PMID: 20530574.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    28. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10920-5. Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR, Klemke RL. PMID: 20534451.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    29. Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1. J Mol Biol. 2010 Apr 09; 397(4):883-92. Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, Jin Y, Klemke RL, Sauder JM, Burley SK. PMID: 20156452.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4299-304. Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. PMID: 20154271.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    31. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One. 2009 Aug 21; 4(8):e6713. Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL, Klemke RL. PMID: 19696929.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    32. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res. 2009 Apr 24; 104(8):952-60. Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI. PMID: 19265037.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    33. Quantitative phosphoproteome analysis of lysophosphatidic acid induced chemotaxis applying dual-step (18)O labeling coupled with immobilized metal-ion affinity chromatography. J Proteome Res. 2008 Oct; 7(10):4215-24. Ding SJ, Wang Y, Jacobs JM, Qian WJ, Yang F, Tolmachev AV, Du X, Wang W, Moore RJ, Monroe ME, Purvine SO, Waters K, Heibeck TH, Adkins JN, Camp DG, Klemke RL, Smith RD. PMID: 18785766.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    34. Catch of the day: zebrafish as a human cancer model. Oncogene. 2008 Jul 31; 27(33):4509-20. Stoletov K, Klemke R. PMID: 18372910.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    35. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2313-8. Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson DA, Stupack DG. PMID: 18268346.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    36. Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1931-6. Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, Clauss TR, Anderson DJ, Liu T, Auberry KJ, Camp DG, Smith RD, Klemke RL. PMID: 18245386.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    37. High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17406-11. Stoletov K, Montel V, Lester RD, Gonias SL, Klemke R. PMID: 17954920.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    38. PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets. Mol Cell Proteomics. 2008 Jan; 7(1):145-62. Wang Y, Klemke RL. PMID: 17934212.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    39. Methods for pseudopodia purification and proteomic analysis. Sci STKE. 2007 Aug 21; 2007(400):pl4. Wang Y, Ding SJ, Wang W, Yang F, Jacobs JM, Camp D, Smith RD, Klemke RL. PMID: 17712138.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    40. Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8328-33. Wang Y, Ding SJ, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG, Smith RD, Klemke RL. PMID: 17494752.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    41. Biochemical purification of pseudopodia from migratory cells. Methods Mol Biol. 2007; 370:55-66. Wang Y, Klemke RL. PMID: 17416987.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    42. Computational methods for comparison of large genomic and proteomic datasets reveal protein markers of metastatic cancer. J Proteome Res. 2006 Apr; 5(4):907-15. Wang Y, Hanley R, Klemke RL. PMID: 16602698.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    43. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature. 2006 Apr 20; 440(7087):1069-72. Pertz O, Hodgson L, Klemke RL, Hahn KM. PMID: 16547516.
      View in: PubMed   Mentions: 342     Fields:    Translation:AnimalsCells
    44. Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII. J Biol Chem. 2006 Feb 03; 281(5):2430-40. Holcomb M, Rufini A, Barilà D, Klemke RL. PMID: 16267043.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    45. Guiding cell migration through directed extension and stabilization of pseudopodia. Exp Cell Res. 2004 Nov 15; 301(1):31-7. Chodniewicz D, Klemke RL. PMID: 15501442.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    46. R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. Mol Biol Cell. 2005 Jan; 16(1):84-96. Wozniak MA, Kwong L, Chodniewicz D, Klemke RL, Keely PJ. PMID: 15525681.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    47. Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim Biophys Acta. 2004 Jul 05; 1692(2-3):63-76. Chodniewicz D, Klemke RL. PMID: 15246680.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    48. Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. J Cell Biol. 2004 May 10; 165(3):421-32. Lin YH, Park ZY, Lin D, Brahmbhatt AA, Rio MC, Yates JR, Klemke RL. PMID: 15138294.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    49. Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene. 2003 Sep 04; 22(38):6071-80. Kain KH, Gooch S, Klemke RL. PMID: 12955086.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    50. Assay for neurite outgrowth quantification. Biotechniques. 2003 Aug; 35(2):254-6. Smit M, Leng J, Klemke RL. PMID: 12951763.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    51. ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis. J Biol Chem. 2003 Apr 11; 278(15):13016-25. Brahmbhatt AA, Klemke RL. PMID: 12571246.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    52. Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol. 2002 Feb 18; 156(4):725-36. Cho SY, Klemke RL. PMID: 11839772.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    53. Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15003-8. Ting AY, Kain KH, Klemke RL, Tsien RY. PMID: 11752449.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    54. Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes. J Biol Chem. 2001 May 11; 276(19):16185-92. Kain KH, Klemke RL. PMID: 11279004.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    55. Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. J Biol Chem. 2000 May 12; 275(19):14729-35. Li E, Stupack DG, Brown SL, Klemke R, Schlaepfer DD, Nemerow GR. PMID: 10799562.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    56. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. J Cell Biol. 2000 Apr 03; 149(1):223-36. Cho SY, Klemke RL. PMID: 10747099.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    57. ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases. J Cell Biol. 2000 Jan 24; 148(2):385-97. Spencer KS, Graus-Porta D, Leng J, Hynes NE, Klemke RL. PMID: 10648571.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    58. Molecular signaling mechanisms of cell migration and invasion. Immunol Res. 2000; 21(2-3):83-8. Stupack DG, Cho SY, Klemke RL. PMID: 10852105.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    59. Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase. J Biol Chem. 1999 Dec 31; 274(53):37855-61. Leng J, Klemke RL, Reddy AC, Cheresh DA. PMID: 10608850.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    60. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. J Cell Biol. 1999 Sep 06; 146(5):1107-16. Cheresh DA, Leng J, Klemke RL. PMID: 10477763.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    61. Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility. J Biol Chem. 1999 Jun 11; 274(24):17164-70. Voice JK, Klemke RL, Le A, Jackson JH. PMID: 10358073.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    62. Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J Cell Biol. 1998 Mar 09; 140(5):1255-63. Eliceiri BP, Klemke R, Strömblad S, Cheresh DA. PMID: 9490736.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    63. Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase. J Virol. 1998 Mar; 72(3):2055-61. Li E, Stupack D, Klemke R, Cheresh DA, Nemerow GR. PMID: 9499060.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    64. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J Cell Biol. 1998 Feb 23; 140(4):961-72. Klemke RL, Leng J, Molander R, Brooks PC, Vuori K, Cheresh DA. PMID: 9472046.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    65. Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol. 1997 Apr 21; 137(2):481-92. Klemke RL, Cai S, Giannini AL, Gallagher PJ, de Lanerolle P, Cheresh DA. PMID: 9128257.
      View in: PubMed   Mentions: 325     Fields:    Translation:AnimalsCells
    66. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J Clin Invest. 1997 Mar 15; 99(6):1390-8. Brooks PC, Klemke RL, Schon S, Lewis JM, Schwartz MA, Cheresh DA. PMID: 9077549.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    67. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J Clin Invest. 1995 Oct; 96(4):1815-22. Brooks PC, Strömblad S, Klemke R, Visscher D, Sarkar FH, Cheresh DA. PMID: 7560073.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    68. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov; 127(3):859-66. Klemke RL, Yebra M, Bayna EM, Cheresh DA. PMID: 7525598.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    69. Comparison of the ontogeny of specific cell surface determinants on normal and delayed implanting mouse embryos. J Reprod Fertil. 1993 Sep; 99(1):167-72. Klemke RL, Weitlauf HM. PMID: 7506791.
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