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Richard Klemke
Title
Professor
School
University of California, San Diego
Department
Pathology
Address
9500 Gilman Drive #0612
CA La Jolla 92093
Phone
858-822-5610
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Research
Research Activities and Funding
Fingerprinting Invasive Membrane Protrusions to Discover Metastatic Signatures
NIH/NCI
R01CA182495
Sep 1, 2014 - Aug 31, 2019
Role: Principal Investigator
Vascular communication in metastatic brain colonization
NIH/NCI
R01CA184594
Apr 3, 2014 - Feb 28, 2019
Role: Principal Investigator
Pre-clinical development of a novel pancreatic cancer chemotherapeutic
NIH/NCI
R43CA180398
Sep 1, 2013 - Aug 31, 2014
Role: Principal Investigator
Imagining Human Cancer Progression in a Novel Zebrafish Model
NIH/NCI
R01CA129231
Aug 1, 2008 - May 31, 2013
Role: Principal Investigator
A Proteomics Research Resource for Integrative Biology
NIH
P41RR018522
Sep 15, 2003 - Jun 30, 2013
Role: Co-Investigator
Mechanisms of Lamellipodia Growth and Retraction
NIH/NIGMS
R01GM068487
Aug 1, 2003 - Jul 31, 2012
Role: Principal Investigator
Survival Mechanisms of Invasive Carcinoma Cells
NIH/NCI
R01CA097022
Jul 1, 2002 - Feb 28, 2018
Role: Principal Investigator
Cell Migration Consortium
NIH
U54GM064346
Sep 15, 2001 - Jul 31, 2014
Role: Co-Investigator
SIGNALING MECHANISMS OF CELL MOTILITY &TUMOR METASTASIS
NIH/NCI
R29CA078493
Aug 1, 1998 - Jul 31, 2003
Role: Principal Investigator
Comprehensive Biology: Exploiting the Yeast Genome
NIH
P41RR011823
Sep 30, 1996 - Jun 30, 2016
Role: Co-Investigator
MOLECULAR BASIS OF INTEGRIN MEDIATED CELL MIGRATION
NIH/NCI
F32CA067442
Mar 31, 1996
Role: Principal Investigator
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H,
Klemke R
, Mantuano E, Gonias SL. The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018 Feb 14; 8(1):2982. PMID: 29445239.
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PubMed
Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL,
Klemke R
. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 Apr 15; 77(8):1997-2007. PMID: 28381547.
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PubMed
Fujimura K, Choi S, Wyse M, Strnadel J, Wright T,
Klemke R
. Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels. J Biol Chem. 2015 Dec 11; 290(50):29907-19. PMID: 26483550; PMCID: PMC4706006 [Available on 12/11/16].
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PubMed
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PubMed Central
Agajanian M, Campeau A, Hoover M, Hou A, Brambilla D, Kim SL,
Klemke R
, Kelber JA. PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFß Responses in Breast Cancer. PLoS One. 2015; 10(8):e0135748. PMID: 26267863; PMCID: PMC4533969.
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PubMed
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PubMed Central
Fujimura K, Wright T, Strnadel J, Kaushal S, Metildi C, Lowy AM, Bouvet M, Kelber JA,
Klemke R
. A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Res. 2014 Nov 15; 74(22):6671-81. PMID: 25261239; PMCID: PMC4233190.
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PubMed
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PubMed Central
Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR,
Klemke R
, Gonias SL, Coppinger JA. Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics. 2015 Jan; 14(1):1-14. PMID: 24997994; PMCID: PMC4288246.
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PubMed
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PubMed Central
Choi S, Kelber J, Jiang X, Strnadel J, Fujimura K, Pasillas M, Coppinger J,
Klemke R
. Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome. Anal Biochem. 2014 Feb 01; 446:102-7. PMID: 24161902; PMCID: PMC3947189.
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PubMed
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PubMed Central
Stoletov K, Strnadel J, Zardouzian E, Momiyama M, Park FD, Kelber JA, Pizzo DP, Hoffman R, VandenBerg SR,
Klemke R
. Role of connexins in metastatic breast cancer and melanoma brain colonization. J Cell Sci. 2013 Feb 15; 126(Pt 4):904-13. PMID: 23321642; PMCID: PMC3625812.
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PubMed
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PubMed Central
Klemke R
, Jiang X, Choi S, Kelber JA. Proteomic and biochemical methods to study the cytoskeletome. Methods Mol Biol. 2013; 1046:203-18. PMID: 23868590.
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PubMed
Bristow JM, Reno TA, Jo M, Gonias SL,
Klemke R
. Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem. 2013 Jan 04; 288(1):123-31. PMID: 23105102; PMCID: PMC3537006.
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PubMed
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PubMed Central
Klemke R
. Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits. Curr Opin Cell Biol. 2012 Oct; 24(5):662-9. PMID: 22980730; PMCID: PMC3489010.
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PubMed
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PubMed Central
Soman P, Kelber JA, Lee JW, Wright TN, Vecchio KS,
Klemke R
, Chen S. Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness. Biomaterials. 2012 Oct; 33(29):7064-70. PMID: 22809641; PMCID: PMC3420339.
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PubMed
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PubMed Central
Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M,
Klemke R
. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res. 2012 May 15; 72(10):2554-64. PMID: 22589274; PMCID: PMC3366503.
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PubMed
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PubMed Central
Wang Y,
Klemke R
. Proteomics method for identification of pseudopodium phosphotyrosine proteins. Methods Mol Biol. 2012; 757:349-65. PMID: 21909922.
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PubMed
Wang Y, Yang F, Fu Y, Huang X, Wang W, Jiang X, Gritsenko MA, Zhao R, Monore ME, Pertz OC, Purvine SO, Orton DJ, Jacobs JM, Camp DG, Smith RD,
Klemke R
. Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem. 2011 May 20; 286(20):18190-201. PMID: 21454597; PMCID: PMC3093891.
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PubMed
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PubMed Central
Jo M, Eastman BM, Webb DL, Stoletov K,
Klemke R
, Gonias SL. Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res. 2010 Nov 01; 70(21):8948-58. PMID: 20940399; PMCID: PMC2970644.
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PubMed
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PubMed Central
Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K,
Klemke R
, Varner JA. A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood. 2010 Dec 16; 116(25):5773-83. PMID: 20826718; PMCID: PMC3031419.
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PubMed
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PubMed Central
Kelber JA,
Klemke R
. PEAK1, a novel kinase target in the fight against cancer. Oncotarget. 2010 Jul; 1(3):219-23. PMID: 21301050; PMCID: PMC3057678.
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PubMed
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PubMed Central
Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S,
Klemke R
. Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci. 2010 Jul 01; 123(Pt 13):2332-41. PMID: 20530574; PMCID: PMC2886748.
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PubMed
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PubMed Central
Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR,
Klemke R
. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10920-5. PMID: 20534451; PMCID: PMC2890752.
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PubMed Central
Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M,
Klemke R
, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4299-304. PMID: 20154271; PMCID: PMC2840076.
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PubMed Central
Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL,
Klemke R
. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One. 2009 Aug 21; 4(8):e6713. PMID: 19696929; PMCID: PMC2725301.
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PubMed Central
Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL,
Klemke R
, Miller YI. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res. 2009 Apr 24; 104(8):952-60. PMID: 19265037; PMCID: PMC2834250.
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PubMed Central
Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL,
Klemke R
, Gerwick WH, Carson DA, Stupack DG. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2313-8. PMID: 18268346; PMCID: PMC2268133.
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PubMed Central
Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, Clauss TR, Anderson DJ, Liu T, Auberry KJ, Camp DG, Smith RD,
Klemke R
. Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1931-6. PMID: 18245386; PMCID: PMC2542865.
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PubMed
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PubMed Central
Stoletov K, Montel V, Lester RD, Gonias SL,
Klemke R
. High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17406-11. PMID: 17954920; PMCID: PMC2077269.
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PubMed
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PubMed Central
Wang Y,
Klemke R
. PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets. Mol Cell Proteomics. 2008 Jan; 7(1):145-62. PMID: 17934212.
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PubMed
Wang Y, Ding SJ, Wang W, Yang F, Jacobs JM, Camp D, Smith RD,
Klemke R
. Methods for pseudopodia purification and proteomic analysis. Sci STKE. 2007 Aug 21; 2007(400):pl4. PMID: 17712138.
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PubMed
Wang Y, Ding SJ, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG, Smith RD,
Klemke R
. Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8328-33. PMID: 17494752; PMCID: PMC1895949.
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PubMed Central
Wang Y,
Klemke R
. Biochemical purification of pseudopodia from migratory cells. Methods Mol Biol. 2007; 370:55-66. PMID: 17416987.
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PubMed
Wang Y, Hanley R,
Klemke R
. Computational methods for comparison of large genomic and proteomic datasets reveal protein markers of metastatic cancer. J Proteome Res. 2006 Apr; 5(4):907-15. PMID: 16602698.
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PubMed
Chodniewicz D,
Klemke R
. Guiding cell migration through directed extension and stabilization of pseudopodia. Exp Cell Res. 2004 Nov 15; 301(1):31-7. PMID: 15501442.
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PubMed
Kain KH, Gooch S,
Klemke R
. Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene. 2003 Sep 04; 22(38):6071-80. PMID: 12955086.
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PubMed
Brahmbhatt AA,
Klemke R
. ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis. J Biol Chem. 2003 Apr 11; 278(15):13016-25. PMID: 12571246.
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Year
Publications
2003
2
2004
1
2006
1
2007
5
2008
2
2009
2
2010
6
2011
1
2012
5
2013
3
2014
2
2015
2
2017
1
2018
1
Richard's Networks
Concepts
Derived automatically from this person's publications.
Cytoskeleton
Pseudopodia
Proteomics
Cell Movement
Protein-Tyrosine Kinases
See all (234) concept(s)
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Co-Authors
People in Profiles who have published with this person.
Bouvet, Michael
Gonias, Steven
Lowy, Andrew
Yang, Feng
Gilder, Andrew
See all (17) people
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Powell, Henry
Witztum, Joseph
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