Calvin Yeang

Title(s)Assistant Professor Of Clinical, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Defining the Role of Lipoprotein(a) and its Oxidized Phospholipids in the Development and Progression of Calcific Aortic Valve Disease Using Unique Transgenic Mouse Models
    NIH K08HL150271Feb 17, 2020 - Jan 31, 2025
    Role: Principal Investigator
    The Role of Lipoprotein(a) and Oxidized Phospholipids in the Development and Treatment of Aortic Valve Stenosis
    American Heart Association 17POST33660462Jul 1, 2017 - Jun 30, 2019

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners. J Vis Exp. 2024 Oct 25; (212). Dinh B, Hoeksema MA, Spann NJ, Rendler J, Cobo I, Glass CK, Yeang C. PMID: 39526601.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. In Search of an Accurate Measurement of LDL-C: Correction for Lp(a)-Cholesterol to Predict Clinical Outcomes. J Am Coll Cardiol. 2024 Jul 09; 84(2):178-181. Tsimikas S, Yeang C, Kronenberg F. PMID: 38960511.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Lipoprotein(a) Testing Trends in a Large Academic Health System in the United States. J Am Heart Assoc. 2023 09 19; 12(18):e031255. Bhatia HS, Hurst S, Desai P, Zhu W, Yeang C. PMID: 37702041; PMCID: PMC10547299.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    4. Lipoprotein(a) and the pooled cohort equations for ASCVD risk prediction: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2023 09; 381:117217. Bhatia HS, Rikhi R, Allen TS, Yeang C, Guan W, Garg PK, Tsai MY, Criqui MH, Shapiro MD, Tsimikas S. PMID: 37607461; PMCID: PMC10659123.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages. Immunity. 2022 08 09; 55(8):1386-1401.e10. Cobo I, Tanaka TN, Chandra Mangalhara K, Lana A, Yeang C, Han C, Schlachetzki J, Challcombe J, Fixsen BR, Sakai M, Li RZ, Fields H, Mokry M, Tsai RG, Bejar R, Prange K, de Winther M, Shadel GS, Glass CK. PMID: 35931086; PMCID: PMC9718507.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    6. Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 03 22; 79(11):1035-1046. Yeang C, Karwatowska-Prokopczuk E, Su F, Dinh B, Xia S, Witztum JL, Tsimikas S. PMID: 35300814; PMCID: PMC8972555.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    7. Trends in testing and prevalence of elevated Lp(a) among patients with aortic valve stenosis. Atherosclerosis. 2022 05; 349:144-150. Bhatia HS, Ma GS, Taleb A, Wilkinson M, Kahn AM, Cotter B, Yeang C, DeMaria AN, Patel MP, Mahmud E, Reeves RR, Tsimikas S. PMID: 35144769; PMCID: PMC9674369.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    8. Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in monocyte and macrophage biology and atherosclerotic cardiovascular disease. Curr Opin Hematol. 2022 01 01; 29(1):1-7. Cobo I, Tanaka T, Glass CK, Yeang C. PMID: 34654019; PMCID: PMC8639635.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. Novel method for quantification of lipoprotein(a)-cholesterol: implications for improving accuracy of LDL-C measurements. J Lipid Res. 2021; 62:100053. Yeang C, Witztum JL, Tsimikas S. PMID: 33636163; PMCID: PMC8042377.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    10. The interconnection between lipoprotein(a), lipoprotein(a) cholesterol and true LDL-cholesterol in the diagnosis of familial hypercholesterolemia. Curr Opin Lipidol. 2020 Dec; 31(6):305-312. Yeang C, Willeit P, Tsimikas S. PMID: 33027223.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a). J Lipid Res. 2020 Sep; 61(9):1263-1270. Gonen A, Yang X, Yeang C, Alekseeva E, Koschinsky M, Witztum JL, Boffa M, Tsimikas S. PMID: 32641432; PMCID: PMC7469883.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Statin therapy increases lipoprotein(a) levels. Eur Heart J. 2020 06 21; 41(24):2275-2284. Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31111151.
      View in: PubMed   Mentions: 148     Fields:    Translation:Humans
    13. Short-term regulation of hematopoiesis by lipoprotein(a) results in the production of pro-inflammatory monocytes. Int J Cardiol. 2020 09 15; 315:81-85. Schnitzler JG, Poels K, Stiekema LCA, Yeang C, Tsimikas S, Kroon J, Stroes ESG, Lutgens E, Seijkens TTP. PMID: 32387421.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation. Circ Res. 2020 05 08; 126(10):1346-1359. Schnitzler JG, Hoogeveen RM, Ali L, Prange KHM, Waissi F, van Weeghel M, Bachmann JC, Versloot M, Borrelli MJ, Yeang C, De Kleijn DPV, Houtkooper RH, Koschinsky ML, de Winther MPJ, Groen AK, Witztum JL, Tsimikas S, Stroes ESG, Kroon J. PMID: 32160811; PMCID: PMC7208285.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    15. ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis. Heart. 2020 05; 106(10):738-745. Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S. PMID: 32054669.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    16. Ancient Remedy for a Modern Disease: Will Celastrol Become a Treatment for Aortic Valve Stenosis? JACC Basic Transl Sci. 2020 Jan; 5(1):50-52. Yeang C, Tsimikas S. PMID: 32043488; PMCID: PMC7000881.
      View in: PubMed   Mentions: 2  
    17. Statins and increases in Lp(a): an inconvenient truth that needs attention. Eur Heart J. 2020 01 01; 41(1):192-193. Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31893480.
      View in: PubMed   Mentions: 11     Fields:    
    18. Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis. J Lipid Res. 2019 12; 60(12):2082-2089. Boffa MB, Marar TT, Yeang C, Viney NJ, Xia S, Witztum JL, Koschinsky ML, Tsimikas S. PMID: 31551368; PMCID: PMC6889713.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCTClinical Trials
    19. Lipoprotein(a) in Patients Undergoing Transcatheter Aortic Valve Replacement. Angiology. 2019 Apr; 70(4):332-336. Ma GS, Wilkinson MJ, Reeves RR, Yeang C, DeMaria AN, Cotter B, Patel M, Mahmud E, Tsimikas S. PMID: 30700108.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids. Cardiovasc Res. 2019 01 01; 115(1):179-189. Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DY, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A. PMID: 29850765; PMCID: PMC6302283.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    21. Association of Mild to Moderate Aortic Valve Stenosis Progression With Higher Lipoprotein(a) and Oxidized Phospholipid Levels: Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2018 12 01; 3(12):1212-1217. Capoulade R, Yeang C, Chan KL, Pibarot P, Tsimikas S. PMID: 30476957; PMCID: PMC6583098.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    22. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.
      View in: PubMed   Mentions: 2     Fields:    
    23. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409; PMCID: PMC6033669.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    24. Relationship between "LDL-C", estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide. J Clin Lipidol. 2018 May - Jun; 12(3):702-710. Viney NJ, Yeang C, Yang X, Xia S, Witztum JL, Tsimikas S. PMID: 29574075.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    25. PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J Am Coll Cardiol. 2018 01 23; 71(3):321-335. Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S. PMID: 29348025; PMCID: PMC5995462.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    26. Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2017 Jun; 2(3):229-240. Torzewski M, Ravandi A, Yeang C, Edel A, Bhindi R, Kath S, Twardowski L, Schmid J, Yang X, Franke UFW, Witztum JL, Tsimikas S. PMID: 29147686; PMCID: PMC5685511.
      View in: PubMed   Mentions: 39  
    27. Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List. Circ Res. 2017 03 31; 120(7):1050-1052. Yeang C, Gordts PL, Tsimikas S. PMID: 28360338; PMCID: PMC5470738.
      View in: PubMed   Mentions: 7     Fields:    
    28. The Prevalence of Lipoprotein(a) Measurement and Degree of Elevation Among 2710 Patients With Calcific Aortic Valve Stenosis in an Academic Echocardiography Laboratory Setting. Angiology. 2017 Oct; 68(9):795-798. Wilkinson MJ, Ma GS, Yeang C, Ang L, Strachan M, DeMaria AN, Tsimikas S, Cotter B. PMID: 28068801.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    29. Lipoprotein(a)-cholesterol levels estimated by vertical auto profile correlate poorly with Lp(a) mass in hyperlipidemic subjects: Implications for clinical practice interpretation of Lp(a)-mediated risk. J Clin Lipidol. 2016 Nov - Dec; 10(6):1389-1396. Yeang C, Clopton PC, Tsimikas S. PMID: 27919356; PMCID: PMC8545497.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    30. Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation. 2016 Aug 23; 134(8):611-24. van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum JL, Tsimikas S, Riksen NP, Stroes ES. PMID: 27496857; PMCID: PMC4995139.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansCellsCTClinical Trials
    31. Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis. Curr Opin Cardiol. 2016 07; 31(4):440-50. Yeang C, Wilkinson MJ, Tsimikas S. PMID: 27205885; PMCID: PMC4956483.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    32. PCSK9 Association With Lipoprotein(a). Circ Res. 2016 06 24; 119(1):29-35. Tavori H, Christian D, Minnier J, Plubell D, Shapiro MD, Yeang C, Giunzioni I, Croyal M, Duell PB, Lambert G, Tsimikas S, Fazio S. PMID: 27121620; PMCID: PMC4920709.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    33. The role of lipoprotein(a) in progression of renal disease: Causality or reverse causality? J Diabetes Complications. 2016 07; 30(5):755-7. Yeang C, Tsimikas S. PMID: 27118508.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). J Clin Lipidol. 2016 May-Jun; 10(3):594-603. Yeang C, Hung MY, Byun YS, Clopton P, Yang X, Witztum JL, Tsimikas S. PMID: 27206947.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    35. Experimental Animal Models Evaluating the Causal Role of Lipoprotein(a) in Atherosclerosis and Aortic Stenosis. Cardiovasc Drugs Ther. 2016 Feb; 30(1):75-85. Yeang C, Cotter B, Tsimikas S. PMID: 26780907.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    36. Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis. J Am Coll Cardiol. 2015 Sep 15; 66(11):1236-1246. Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. PMID: 26361154.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansCells
    37. 'LDL-C' = LDL-C + Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Curr Opin Lipidol. 2015 Jun; 26(3):169-78. Yeang C, Witztum JL, Tsimikas S. PMID: 25943842.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    38. HDL-C, ABCA1-mediated cholesterol efflux, and lipoprotein(a): insights into a potential novel physiologic role of lipoprotein(a). J Lipid Res. 2015 Jul; 56(7):1241-4. Yeang C, Tsimikas S. PMID: 26014961; PMCID: PMC4479328.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    39. Imaging of oxidation-specific epitopes with targeted nanoparticles to detect high-risk atherosclerotic lesions: progress and future directions. J Cardiovasc Transl Res. 2014 Nov; 7(8):719-36. Briley-Saebo K, Yeang C, Witztum JL, Tsimikas S. PMID: 25297940; PMCID: PMC4233166.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    40. Subcellular targeting domains of sphingomyelin synthase 1 and 2. Nutr Metab (Lond). 2011 Dec 14; 8:89. Yeang C, Ding T, Chirico WJ, Jiang XC. PMID: 22168400; PMCID: PMC3264500.
      View in: PubMed   Mentions: 13  
    41. Role of phospholipid transfer protein in high-density lipoprotein- mediated reverse cholesterol transport. Curr Atheroscler Rep. 2011 Jun; 13(3):242-8. Yazdanyar A, Yeang C, Jiang XC. PMID: 21365262; PMCID: PMC3085729.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    42. Sphingomyelin synthase 2 (SMS2) deficiency attenuates LPS-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Mar; 300(3):L430-40. Gowda S, Yeang C, Wadgaonkar S, Anjum F, Grinkina N, Cutaia M, Jiang XC, Wadgaonkar R. PMID: 21191108; PMCID: PMC3284317.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    43. Diet-induced lipid accumulation in phospholipid transfer protein-deficient mice: its atherogenicity and potential mechanism. J Lipid Res. 2010 Oct; 51(10):2993-3002. Yeang C, Qin S, Chen K, Wang DQ, Jiang XC. PMID: 20543142; PMCID: PMC2936749.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    44. The domain responsible for sphingomyelin synthase (SMS) activity. Biochim Biophys Acta. 2008 Oct; 1781(10):610-7. Yeang C, Varshney S, Wang R, Zhang Y, Ye D, Jiang XC. PMID: 18694848; PMCID: PMC3426831.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    45. Phospholipid transfer protein-deficient mice absorb less cholesterol. Arterioscler Thromb Vasc Biol. 2007 Sep; 27(9):2014-21. Liu R, Iqbal J, Yeang C, Wang DQ, Hussain MM, Jiang XC. PMID: 17641249.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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