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Alexander (Sasha) Kauffman

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentReproductive Medicine
Address9500 Gilman Drive #0674
La Jolla CA 92093
Phone858-246-0219
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    Collapse Biography 
    Collapse Education and Training
    U.C. BerkeleyPhDIntegrative Biology
    University of VirginiaPostdocBehavioral Neuroscience
    University of WashingtonPostdocMolecular Neuroendocrinology

    Collapse Research 
    Collapse Research Activities and Funding
    Neuroendocrine regulation of puberty and reproductive development
    NIH/NICHD R01HD090161Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Project 2
    NIH P50 HD012303Aug 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    National Science Foundation NSF IOS-1457226Aug 1, 2015 - Jul 31, 2019
    Role: Principal Investigator
    NIH R01 HD082567Apr 1, 2015 - Jan 31, 2020
    Role: Co-Investigator
    Neuroendocrine regulation of the reproductive axis during puberty and development
    NIH/NICHD R01HD065856Aug 10, 2010 - Jul 31, 2015
    Role: Principal Investigator
    National Science Foundation NSF IOS-1025893Aug 1, 2010 - Jul 31, 2015
    Role: Principal Investigator
    Role of Kiss1 neurons in the seasonal and circadian control of reproduction
    NIH/NICHD R00HD056157Sep 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Role of Kiss1 neurons in the seasonal and circadian control of reproduction
    NIH/NICHD K99HD056157Sep 1, 2007 - Aug 31, 2009
    Role: Principal Investigator
    Neuroendocrine control of feeding and reproduction
    NIH/NIMH F32MH070084May 1, 2004 - Apr 30, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lehman MN, Coolen LM, Steiner RA, Neal-Perry G, Wang L, Moenter SM, Moore AM, Goodman RL, Hwa-Yeo S, Padilla SL, Kauffman A, Garcia J, Kelly MJ, Clarkson J, Radovick S, Babwah AV, Leon S, Tena-Sempere M, Comninos A, Seminara S, Dhillo WS, Levine J, Terasawa E, Negron A, Herbison AE. The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond":Unresolved questions, challenges and future directions for the field. J Neuroendocrinol. 2018 Apr 14; e12600. PMID: 29656508.
      View in: PubMed
    2. Yang JA, Song CI, Hughes JK, Kreisman MJ, Parra RA, Haisenleder DJ, Kauffman A, Breen KM. Acute Psychosocial Stress Inhibits LH Pulsatility and Kiss1 Neuronal Activation in Female Mice. Endocrinology. 2017 11 01; 158(11):3716-3723. PMID: 28973125.
      View in: PubMed
    3. Poling MC, Luo EY, Kauffman A. Sex Differences in Steroid Receptor Coexpression and Circadian-Timed Activation of Kisspeptin and RFRP-3 Neurons May Contribute to the Sexually Dimorphic Basis of the LH Surge. Endocrinology. 2017 10 01; 158(10):3565-3578. PMID: 28938464.
      View in: PubMed
    4. Stephens SBZ, Kauffman A. Regulation and Possible Functions of Kisspeptin in the Medial Amygdala. Front Endocrinol (Lausanne). 2017; 8:191. PMID: 28824550.
      View in: PubMed
    5. Stephens SBZ, Rouse ML, Tolson KP, Liaw RB, Parra RA, Chahal N, Kauffman A. Effects of Selective Deletion of Tyrosine Hydroxylase from Kisspeptin Cells on Puberty and Reproduction in Male and Female Mice. eNeuro. 2017 May-Jun; 4(3). PMID: 28660243.
      View in: PubMed
    6. Schoeller EL, Clark DD, Dey S, Cao NV, Semaan SJ, Chao LW, Kauffman A, Stowers L, Mellon PL. Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology. 2016 Dec; 157(12):4914-4929. PMID: 27704948.
      View in: PubMed
    7. De Bond JP, Tolson KP, Nasamran C, Kauffman A, Smith JT. Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure. J Neuroendocrinol. 2016 10; 28(10). PMID: 27601011.
      View in: PubMed
    8. Tolson KP, Garcia C, Delgado I, Marooki N, Kauffman A. Metabolism and Energy Expenditure, But Not Feeding or Glucose Tolerance, Are Impaired in Young Kiss1r KO Female Mice. Endocrinology. 2016 Nov; 157(11):4192-4199. PMID: 27649089.
      View in: PubMed
    9. Stephens SB, Chahal N, Munaganuru N, Parra RA, Kauffman A. Estrogen Stimulation of Kiss1 Expression in the Medial Amygdala Involves Estrogen Receptor-a But Not Estrogen Receptor-ß. Endocrinology. 2016 Oct; 157(10):4021-4031. PMID: 27564649.
      View in: PubMed
    10. Luo E, Stephens SB, Chaing S, Munaganuru N, Kauffman A, Breen KM. Corticosterone Blocks Ovarian Cyclicity and the LH Surge via Decreased Kisspeptin Neuron Activation in Female Mice. Endocrinology. 2016 Mar; 157(3):1187-99. PMID: 26697722; PMCID: PMC4769373 [Available on 03/01/17].
    11. Poling MC, Kauffman A. Regulation and Function of RFRP-3 (GnIH) Neurons during Postnatal Development. Front Endocrinol (Lausanne). 2015; 6:150. PMID: 26441840; PMCID: PMC4585233.
    12. Kauffman A, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175; PMCID: PMC4710190.
    13. Stephens SB, Tolson KP, Rouse ML, Poling MC, Hashimoto-Partyka MK, Mellon PL, Kauffman A. Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice. Endocrinology. 2015 Sep; 156(9):3091-7. PMID: 26076042; PMCID: PMC4541622.
    14. Xie C, Jonak CR, Kauffman A, Coss D. Gonadotropin and kisspeptin gene expression, but not GnRH, are impaired in cFOS deficient mice. Mol Cell Endocrinol. 2015 Aug 15; 411:223-31. PMID: 25958044; PMCID: PMC4764054.
    15. Russo KA, La JL, Stephens SB, Poling MC, Padgaonkar NA, Jennings KJ, Piekarski DJ, Kauffman A, Kriegsfeld LJ. Circadian Control of the Female Reproductive Axis Through Gated Responsiveness of the RFRP-3 System to VIP Signaling. Endocrinology. 2015 Jul; 156(7):2608-18. PMID: 25872006; PMCID: PMC4475714.
    16. Semaan SJ, Kauffman A. Daily successive changes in reproductive gene expression and neuronal activation in the brains of pubertal female mice. Mol Cell Endocrinol. 2015 Feb 05; 401:84-97. PMID: 25498961; PMCID: PMC4312730.
    17. Poling MC, Shieh MP, Munaganuru N, Luo E, Kauffman A. Examination of the influence of leptin and acute metabolic challenge on RFRP-3 neurons of mice in development and adulthood. Neuroendocrinology. 2014; 100(4):317-33. PMID: 25378037; PMCID: PMC4329049.
    18. Hoffmann HM, Tamrazian A, Xie H, Pérez-Millán MI, Kauffman A, Mellon PL. Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology. 2014 Oct; 155(10):4043-53. PMID: 25060364; PMCID: PMC4164932.
    19. Koemeter-Cox AI, Sherwood TW, Green JA, Steiner RA, Berbari NF, Yoder BK, Kauffman A, Monsma PC, Brown A, Askwith CC, Mykytyn K. Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10335-40. PMID: 24982149; PMCID: PMC4104922.
    20. Tolson KP, Garcia C, Yen S, Simonds S, Stefanidis A, Lawrence A, Smith JT, Kauffman A. Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity. J Clin Invest. 2014 Jul; 124(7):3075-9. PMID: 24937427; PMCID: PMC4071390.
    21. Kauffman A, Sun Y, Kim J, Khan AR, Shu J, Neal-Perry G. Vasoactive intestinal peptide modulation of the steroid-induced LH surge involves kisspeptin signaling in young but not in middle-aged female rats. Endocrinology. 2014 Jun; 155(6):2222-32. PMID: 24654782; PMCID: PMC4020928.
    22. Di Giorgio NP, Semaan SJ, Kim J, López PV, Bettler B, Libertun C, Lux-Lantos VA, Kauffman A. Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice. Endocrinology. 2014 Mar; 155(3):1033-44. PMID: 24424047; PMCID: PMC3929734.
    23. Di Giorgio NP, Catalano PN, López PV, González B, Semaan SJ, López GC, Kauffman A, Rulli SB, Somoza GM, Bettler B, Libertun C, Lux-Lantos VA. Lack of functional GABAB receptors alters Kiss1 , Gnrh1 and Gad1 mRNA expression in the medial basal hypothalamus at postnatal day 4. Neuroendocrinology. 2013; 98(3):212-23. PMID: 24080944; PMCID: PMC3915412.
    24. Kim J, Tolson KP, Dhamija S, Kauffman A. Developmental GnRH signaling is not required for sexual differentiation of kisspeptin neurons but is needed for maximal Kiss1 gene expression in adult females. Endocrinology. 2013 Sep; 154(9):3273-83. PMID: 23825121; PMCID: PMC3749477.
    25. Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Coss D, Kauffman A, Mellon PL. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol. 2013 Aug; 27(8):1283-94. PMID: 23770611; PMCID: PMC3725344.
    26. Dror T, Franks J, Kauffman A. Analysis of multiple positive feedback paradigms demonstrates a complete absence of LH surges and GnRH activation in mice lacking kisspeptin signaling. Biol Reprod. 2013 Jun; 88(6):146. PMID: 23595904; PMCID: PMC4070868.
    27. Semaan SJ, Kauffman A. Emerging concepts on the epigenetic and transcriptional regulation of the Kiss1 gene. Int J Dev Neurosci. 2013 Oct; 31(6):452-62. PMID: 23510953; PMCID: PMC3703475.
    28. Semaan SJ, Tolson KP, Kauffman A. The development of kisspeptin circuits in the Mammalian brain. Adv Exp Med Biol. 2013; 784:221-52. PMID: 23550009; PMCID: PMC4305450.
    29. Witham EA, Meadows JD, Shojaei S, Kauffman A, Mellon PL. Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 2012 Sep; 153(9):4522-32. PMID: 22778229; PMCID: PMC3423623.
    30. Poling MC, Kauffman A. Organizational and activational effects of sex steroids on kisspeptin neuron development. Front Neuroendocrinol. 2013 Jan; 34(1):3-17. PMID: 22728025; PMCID: PMC3725275.
    31. Rizwan MZ, Poling MC, Corr M, Cornes PA, Augustine RA, Quennell JH, Kauffman A, Anderson GM. RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology. 2012 Aug; 153(8):3770-9. PMID: 22691552.
      View in: PubMed
    32. Semaan SJ, Dhamija S, Kim J, Ku EC, Kauffman A. Assessment of epigenetic contributions to sexually-dimorphic Kiss1 expression in the anteroventral periventricular nucleus of mice. Endocrinology. 2012 Apr; 153(4):1875-86. PMID: 22374971; PMCID: PMC3320252.
    33. Poling MC, Kim J, Dhamija S, Kauffman A. Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus. Endocrinology. 2012 Apr; 153(4):1827-40. PMID: 22355072; PMCID: PMC3320244.
    34. Poling MC, Kauffman A. Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology. 2012 Feb; 153(2):782-93. PMID: 22202164; PMCID: PMC3275395.
    35. Kim J, Semaan SJ, Clifton DK, Steiner RA, Dhamija S, Kauffman A. Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology. 2011 May; 152(5):2020-30. PMID: 21363930; PMCID: PMC3075940.
    36. Semaan SJ, Murray EK, Poling MC, Dhamija S, Forger NG, Kauffman A. BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice. Endocrinology. 2010 Dec; 151(12):5807-17. PMID: 20926580; PMCID: PMC2999490.
    37. Semaan SJ, Kauffman A. Sexual differentiation and development of forebrain reproductive circuits. Curr Opin Neurobiol. 2010 Aug; 20(4):424-31. PMID: 20471241; PMCID: PMC2937059.
    38. Kauffman A. Gonadal and nongonadal regulation of sex differences in hypothalamic Kiss1 neurones. J Neuroendocrinol. 2010 Jul; 22(7):682-91. PMID: 20492362; PMCID: PMC3096441.
    39. Paul MJ, Tuthill C, Kauffman A, Zucker I. Pelage insulation, litter size, and ambient temperature impact maternal energy intake and offspring development during lactation. Physiol Behav. 2010 May 11; 100(2):128-34. PMID: 20184907; PMCID: PMC2886721.
    40. Kauffman A. Coming of age in the kisspeptin era: sex differences, development, and puberty. Mol Cell Endocrinol. 2010 Aug 05; 324(1-2):51-63. PMID: 20083160; PMCID: PMC2902563.
    41. Kauffman A, Bojkowska K, Rissman EF. Critical periods of susceptibility to short-term energy challenge during pregnancy: Impact on fertility and offspring development. Physiol Behav. 2010 Jan 12; 99(1):100-8. PMID: 19891981; PMCID: PMC2795402.
    42. Kauffman A, Navarro VM, Kim J, Clifton DK, Steiner RA. Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1212-21. PMID: 19755669.
      View in: PubMed
    43. Robertson JL, Clifton DK, de la Iglesia HO, Steiner RA, Kauffman A. Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge. Endocrinology. 2009 Aug; 150(8):3664-71. PMID: 19443569; PMCID: PMC2717859.
    44. Roseweir AK, Kauffman A, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci. 2009 Mar 25; 29(12):3920-9. PMID: 19321788; PMCID: PMC3035813.
    45. Kauffman A. Sexual differentiation and the Kiss1 system: hormonal and developmental considerations. Peptides. 2009 Jan; 30(1):83-93. PMID: 18644414; PMCID: PMC2631352.
    46. Kauffman A, Clifton DK, Steiner RA. Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci. 2007 Oct; 30(10):504-11. PMID: 17904653.
      View in: PubMed
    47. Kauffman A, Park JH, McPhie-Lalmansingh AA, Gottsch ML, Bodo C, Hohmann JG, Pavlova MN, Rohde AD, Clifton DK, Steiner RA, Rissman EF. The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci. 2007 Aug 15; 27(33):8826-35. PMID: 17699664.
      View in: PubMed
    48. Kauffman A, Gottsch ML, Roa J, Byquist AC, Crown A, Clifton DK, Hoffman GE, Steiner RA, Tena-Sempere M. Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology. 2007 Apr; 148(4):1774-83. PMID: 17204549.
      View in: PubMed
    49. Park JH, Kauffman A, Paul MJ, Butler MP, Beery AK, Costantini RM, Zucker I. Interval timer control of puberty in photoinhibited Siberian hamsters. J Biol Rhythms. 2006 Oct; 21(5):373-83. PMID: 16998157.
      View in: PubMed
    50. Kauffman A, Bojkowska K, Wills A, Rissman EF. Gonadotropin-releasing hormone-II messenger ribonucleic acid and protein content in the mammalian brain are modulated by food intake. Endocrinology. 2006 Nov; 147(11):5069-77. PMID: 16873537.
      View in: PubMed
    51. Kauffman A, Buenzle J, Fraley GS, Rissman EF. Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice. Horm Behav. 2005 Aug; 48(2):141-51. PMID: 16042964.
      View in: PubMed
    52. Freeman DA, Lewis DA, Kauffman A, Blum RM, Dark J. Reduced leptin concentrations are permissive for display of torpor in Siberian hamsters. Am J Physiol Regul Integr Comp Physiol. 2004 Jul; 287(1):R97-R103. PMID: 15191926.
      View in: PubMed
    53. Paul MJ, Kauffman A, Zucker I. Feeding schedule controls circadian timing of daily torpor in SCN-ablated Siberian hamsters. J Biol Rhythms. 2004 Jun; 19(3):226-37. PMID: 15155009.
      View in: PubMed
    54. Kauffman A, Rissman EF. A critical role for the evolutionarily conserved gonadotropin-releasing hormone II: mediation of energy status and female sexual behavior. Endocrinology. 2004 Aug; 145(8):3639-46. PMID: 15105381.
      View in: PubMed
    55. Kauffman A, Paul MJ, Zucker I. Increased heat loss affects hibernation in golden-mantled ground squirrels. Am J Physiol Regul Integr Comp Physiol. 2004 Jul; 287(1):R167-73. PMID: 15016623.
      View in: PubMed
    56. Kauffman A, Rissman EF. The evolutionarily conserved gonadotropin-releasing hormone II modifies food intake. Endocrinology. 2004 Feb; 145(2):686-91. PMID: 14576176.
      View in: PubMed
    57. Kauffman A, Paul MJ, Butler MP, Zucker I. Huddling, locomotor, and nest-building behaviors of furred and furless Siberian hamsters. Physiol Behav. 2003 Jul; 79(2):247-56. PMID: 12834796.
      View in: PubMed
    58. Kauffman A, Zucker I. Testicular recrudescence in intermediate day lengths reflects loss of photoperiodic memory in Siberian hamsters. J Biol Rhythms. 2002 Aug; 17(4):345-52. PMID: 12164250.
      View in: PubMed