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Shunichi Shimasaki

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentReproductive Medicine
Address9500 Gilman Drive #0633
La Jolla CA 92093
Phone858-822-1414
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    Collapse Research 
    Collapse Research Activities and Funding
    A Novel Function of the Oocyte in Estrogen-Regulated FSH Action
    NIH/NICHD R21HD060032Aug 1, 2008 - Jul 31, 2011
    Role: Principal Investigator
    Molecular Basis of BMP-15 Function
    NIH/NICHD R01HD041494May 1, 2002 - Aug 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Belli M, Iwata N, Nakamura T, Iwase A, Stupack D, Shimasaki S. FOXL2C134W-Induced CYP19 Expression via Cooperation With SMAD3 in HGrC1 Cells. Endocrinology. 2018 Apr 01; 159(4):1690-1703. PMID: 29471425.
      View in: PubMed
    2. Belli M, Shimasaki S. Molecular Aspects and Clinical Relevance of GDF9 and BMP15 in Ovarian Function. Vitam Horm. 2018; 107:317-348. PMID: 29544636.
      View in: PubMed
    3. Takahashi N, Harada M, Hirota Y, Nose E, Azhary JM, Koike H, Kunitomi C, Yoshino O, Izumi G, Hirata T, Koga K, Wada-Hiraike O, Chang RJ, Shimasaki S, Fujii T, Osuga Y. Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis. Sci Rep. 2017 Sep 07; 7(1):10824. PMID: 28883502.
      View in: PubMed
    4. Yamada-Nomoto K, Yoshino O, Akiyama I, Iwase A, Ono Y, Nakamura T, Harada M, Nakashima A, Shima T, Ushijima A, Osuga Y, Chang RJ, Shimasaki S, Saito S. PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-ß and TNF-a in mononuclear cells by insulin-sensitizing drugs. Am J Reprod Immunol. 2017 07; 78(1). PMID: 28337819.
      View in: PubMed
    5. Cook-Andersen H, Curnow KJ, Su HI, Chang RJ, Shimasaki S. Growth and differentiation factor 9 promotes oocyte growth at the primary but not the early secondary stage in three-dimensional follicle culture. J Assist Reprod Genet. 2016 Aug; 33(8):1067-77. PMID: 27155601; PMCID: PMC4974221 [Available on 08/01/17].
    6. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175; PMCID: PMC4710190.
    7. Shayya RF, Rosencrantz MA, Chuan SS, Cook-Andersen H, Roudebush WE, Irene Su H, Shimasaki S, Chang RJ. Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome. Fertil Steril. 2014 Jan; 101(1):275-9. PMID: 24188875.
      View in: PubMed
    8. Hoang YD, McTavish KJ, Chang RJ, Shimasaki S. Paracrine regulation of theca androgen production by granulosa cells in the ovary. Fertil Steril. 2013 Aug; 100(2):561-7. PMID: 23706336; PMCID: PMC3732568.
    9. Miyoshi T, Otsuka F, Shimasaki S. GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells. Biochem Biophys Res Commun. 2013 May 03; 434(2):401-6. PMID: 23583200; PMCID: PMC3722898.
    10. McTavish KJ, Nonis D, Hoang YD, Shimasaki S. Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells. Mol Cell Endocrinol. 2013 Jun 15; 372(1-2):57-64. PMID: 23567549; PMCID: PMC3669547.
    11. Nonis D, McTavish KJ, Shimasaki S. Essential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434. Mol Cell Endocrinol. 2013 Jun 15; 372(1-2):42-8. PMID: 23523567; PMCID: PMC3657561.
    12. Hashimoto O, Takagi R, Yanuma F, Doi S, Shindo J, Endo H, Hasegawa Y, Shimasaki S. Identification and characterization of canine growth differentiation factor-9 and its splicing variant. Gene. 2012 May 15; 499(2):266-72. PMID: 22446043; PMCID: PMC3367864.
    13. Otsuka F, McTavish KJ, Shimasaki S. Integral role of GDF-9 and BMP-15 in ovarian function. Mol Reprod Dev. 2011 Jan; 78(1):9-21. PMID: 21226076; PMCID: PMC3051839.
    14. Inagaki K, Shimasaki S. Impaired production of BMP-15 and GDF-9 mature proteins derived from proproteins WITH mutations in the proregion. Mol Cell Endocrinol. 2010 Oct 26; 328(1-2):1-7. PMID: 20547206; PMCID: PMC2934881.
    15. Tibaldi E, Arrigoni G, Martinez HM, Inagaki K, Shimasaki S, Pinna LA. Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9. FEBS Lett. 2010 Feb 19; 584(4):801-5. PMID: 20067794; PMCID: PMC2822075.
    16. Mutiara S, Kanasaki H, Oride A, Purwana IN, Shimasaki S, Yamamoto H, Miyazaki K. Follistatin gene expression by gonadotropin-releasing hormone: a role for cyclic AMP and mitogen-activated protein kinase signaling pathways in clonal gonadotroph LbetaT2 cells. Mol Cell Endocrinol. 2009 Aug 13; 307(1-2):125-32. PMID: 19533841.
      View in: PubMed
    17. McMahon HE, Hashimoto O, Mellon PL, Shimasaki S. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology. 2008 Jun; 149(6):2807-15. PMID: 18308851; PMCID: PMC2408818.
    18. Wachs DS, Coffler MS, Malcom PJ, Shimasaki S, Chang RJ. Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008 May; 93(5):1827-33. PMID: 18285408; PMCID: PMC2386684.
    19. Saito S, Yano K, Sharma S, McMahon HE, Shimasaki S. Characterization of the post-translational modification of recombinant human BMP-15 mature protein. Protein Sci. 2008 Feb; 17(2):362-70. PMID: 18227435; PMCID: PMC2222730.
    20. McMahon HE, Sharma S, Shimasaki S. Phosphorylation of bone morphogenetic protein-15 and growth and differentiation factor-9 plays a critical role in determining agonistic or antagonistic functions. Endocrinology. 2008 Feb; 149(2):812-7. PMID: 18006624; PMCID: PMC2219307.
    21. Sugiura K, Su YQ, Diaz FJ, Pangas SA, Sharma S, Wigglesworth K, O'Brien MJ, Matzuk MM, Shimasaki S, Eppig JJ. Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. Development. 2007 Jul; 134(14):2593-603. PMID: 17553902.
      View in: PubMed
    22. Lerch TF, Shimasaki S, Woodruff TK, Jardetzky TS. Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions. J Biol Chem. 2007 May 25; 282(21):15930-9. PMID: 17409095.
      View in: PubMed
    23. Shimasaki S. BMP-15 regulation of ovulation quota in mammals. Reprod Med Biol. 2006 Dec; 5(4):245-248. PMID: 29699253.
      View in: PubMed
    24. Yoshino O, McMahon HE, Sharma S, Shimasaki S. A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10678-83. PMID: 16818886; PMCID: PMC1502291.
    25. Kihara S, Yamamoto H, Ohba T, Shimasaki S, Okamura H. Activation of follistatin promoter by GnRH in LbetaT2 gonadotroph cells. Endocr J. 2006 Apr; 53(2):225-35. PMID: 16618982.
      View in: PubMed
    26. Clelland E, Kohli G, Campbell RK, Sharma S, Shimasaki S, Peng C. Bone morphogenetic protein-15 in the zebrafish ovary: complementary deoxyribonucleic acid cloning, genomic organization, tissue distribution, and role in oocyte maturation. Endocrinology. 2006 Jan; 147(1):201-9. PMID: 16210364.
      View in: PubMed
    27. Otsuka F, Moore RK, Wang X, Sharma S, Miyoshi T, Shimasaki S. Essential role of the oocyte in estrogen amplification of follicle-stimulating hormone signaling in granulosa cells. Endocrinology. 2005 Aug; 146(8):3362-7. PMID: 15878960.
      View in: PubMed
    28. Moore RK, Shimasaki S. Molecular biology and physiological role of the oocyte factor, BMP-15. Mol Cell Endocrinol. 2005 Apr 29; 234(1-2):67-73. PMID: 15836954.
      View in: PubMed
    29. Hashimoto O, Moore RK, Shimasaki S. Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5426-31. PMID: 15809424; PMCID: PMC556231.
    30. Thomas FH, Ethier JF, Shimasaki S, Vanderhyden BC. Follicle-stimulating hormone regulates oocyte growth by modulation of expression of oocyte and granulosa cell factors. Endocrinology. 2005 Feb; 146(2):941-9. PMID: 15539559.
      View in: PubMed
    31. Lee WS, Yoon SJ, Yoon TK, Cha KY, Lee SH, Shimasaki S, Lee S, Lee KA. Effects of bone morphogenetic protein-7 (BMP-7) on primordial follicular growth in the mouse ovary. Mol Reprod Dev. 2004 Oct; 69(2):159-63. PMID: 15293217.
      View in: PubMed
    32. Moore RK, Erickson GF, Shimasaki S. Are BMP-15 and GDF-9 primary determinants of ovulation quota in mammals? Trends Endocrinol Metab. 2004 Oct; 15(8):356-61. PMID: 15380806.
      View in: PubMed
    33. Matsui M, Sonntag B, Hwang SS, Byerly T, Hourvitz A, Adashi EY, Shimasaki S, Erickson GF. Pregnancy-associated plasma protein-a production in rat granulosa cells: stimulation by follicle-stimulating hormone and inhibition by the oocyte-derived bone morphogenetic protein-15. Endocrinology. 2004 Aug; 145(8):3686-95. PMID: 15087430.
      View in: PubMed
    34. Liao WX, Moore RK, Shimasaki S. Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9. J Biol Chem. 2004 Apr 23; 279(17):17391-6. PMID: 14970198.
      View in: PubMed
    35. Shimasaki S, Moore RK, Otsuka F, Erickson GF. The bone morphogenetic protein system in mammalian reproduction. Endocr Rev. 2004 Feb; 25(1):72-101. PMID: 14769828.
      View in: PubMed
    36. Erickson GF, Shimasaki S. The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. Reprod Biol Endocrinol. 2003 Feb 05; 1:9. PMID: 12741959; PMCID: PMC153494.
    37. Shimasaki S, Moore RK, Erickson GF, Otsuka F. The role of bone morphogenetic proteins in ovarian function. Reprod Suppl. 2003; 61:323-37. PMID: 14635945.
      View in: PubMed
    38. Otsuka F, Shimasaki S. A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes. Endocrinology. 2002 Dec; 143(12):4938-41. PMID: 12446622.
      View in: PubMed
    39. Liao WX, Moore RK, Otsuka F, Shimasaki S. Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep. J Biol Chem. 2003 Feb 07; 278(6):3713-9. PMID: 12446716.
      View in: PubMed
    40. Moore RK, Otsuka F, Shimasaki S. Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. J Biol Chem. 2003 Jan 03; 278(1):304-10. PMID: 12419820.
      View in: PubMed
    41. Otsuka F, Shimasaki S. A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: its role in regulating granulosa cell mitosis. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8060-5. PMID: 12048244; PMCID: PMC123020.
    42. Nakatani M, Yamakawa N, Matsuzaki T, Shimasaki S, Sugino H, Tsuchida K. Genomic organization and promoter analysis of mouse follistatin-related gene (FLRG). Mol Cell Endocrinol. 2002 Mar 28; 189(1-2):117-23. PMID: 12039070.
      View in: PubMed
    43. Teixeira Filho FL, Baracat EC, Lee TH, Suh CS, Matsui M, Chang RJ, Shimasaki S, Erickson GF. Aberrant expression of growth differentiation factor-9 in oocytes of women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Mar; 87(3):1337-44. PMID: 11889206.
      View in: PubMed
    44. Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang RJ, Erickson GF. A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7282-7. PMID: 10377406; PMCID: PMC22077.