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Shunichi Shimasaki

Title(s)Professor, Reproductive Medicine
SchoolHealth Sciences
Phone858-822-1414
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    Collapse Research 
    Collapse Research Activities and Funding
    Project III - The Role of Androgen on Follicle Function
    NIH/NICHD P50HD012303Aug 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    Contribution of the FOXL2 mutation to granulosa cell tumorigenesis
    UC SAN DIEGO ACADEMIC SENATE RN138BApr 1, 2014 - Mar 31, 2015
    Role: Principal Investigator
    A Novel Function of the Oocyte in Estrogen-Regulated FSH Action
    NIH/NICHD R21HD060032Aug 1, 2008 - Jul 31, 2011
    Role: Principal Investigator
    Molecular Basis of BMP-15 Function
    NIH/NICHD R01HD041494May 1, 2002 - Aug 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Belli M, Secchi C, Stupack D, Shimasaki S. FOXO1 Negates the Cooperative Action of FOXL2C134W and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3. J Endocr Soc. 2019 Nov 01; 3(11):2064-2081. PMID: 31701078.
      View in: PubMed
    2. Belli M, Iwata N, Nakamura T, Iwase A, Stupack D, Shimasaki S. FOXL2C134W-Induced CYP19 Expression via Cooperation With SMAD3 in HGrC1 Cells. Endocrinology. 2018 04 01; 159(4):1690-1703. PMID: 29471425.
      View in: PubMed
    3. Belli M, Shimasaki S. Molecular Aspects and Clinical Relevance of GDF9 and BMP15 in Ovarian Function. Vitam Horm. 2018; 107:317-348. PMID: 29544636.
      View in: PubMed
    4. Takahashi N, Harada M, Hirota Y, Nose E, Azhary JM, Koike H, Kunitomi C, Yoshino O, Izumi G, Hirata T, Koga K, Wada-Hiraike O, Chang RJ, Shimasaki S, Fujii T, Osuga Y. Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis. Sci Rep. 2017 09 07; 7(1):10824. PMID: 28883502.
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    5. Yamada-Nomoto K, Yoshino O, Akiyama I, Iwase A, Ono Y, Nakamura T, Harada M, Nakashima A, Shima T, Ushijima A, Osuga Y, Chang RJ, Shimasaki S, Saito S. PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-ß and TNF-a in mononuclear cells by insulin-sensitizing drugs. Am J Reprod Immunol. 2017 07; 78(1). PMID: 28337819.
      View in: PubMed
    6. Cook-Andersen H, Curnow KJ, Su HI, Chang RJ, Shimasaki S. Growth and differentiation factor 9 promotes oocyte growth at the primary but not the early secondary stage in three-dimensional follicle culture. J Assist Reprod Genet. 2016 Aug; 33(8):1067-77. PMID: 27155601.
      View in: PubMed
    7. Koga T, Suico MA, Shimasaki S, Watanabe E, Kai Y, Koyama K, Omachi K, Morino-Koga S, Sato T, Shuto T, Mori K, Hino S, Nakao M, Kai H. Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3ß Signaling Pathway and Promotes Hepatocellular Injury. J Biol Chem. 2015 Dec 18; 290(51):30366-74. PMID: 26499802.
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    8. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175.
      View in: PubMed
    9. Shayya RF, Rosencrantz MA, Chuan SS, Cook-Andersen H, Roudebush WE, Irene Su H, Shimasaki S, Chang RJ. Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome. Fertil Steril. 2014 Jan; 101(1):275-9. PMID: 24188875.
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    10. Hoang YD, McTavish KJ, Chang RJ, Shimasaki S. Paracrine regulation of theca androgen production by granulosa cells in the ovary. Fertil Steril. 2013 Aug; 100(2):561-7. PMID: 23706336.
      View in: PubMed
    11. Miyoshi T, Otsuka F, Shimasaki S. GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells. Biochem Biophys Res Commun. 2013 May 03; 434(2):401-6. PMID: 23583200.
      View in: PubMed
    12. McTavish KJ, Nonis D, Hoang YD, Shimasaki S. Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells. Mol Cell Endocrinol. 2013 Jun 15; 372(1-2):57-64. PMID: 23567549.
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    13. Nonis D, McTavish KJ, Shimasaki S. Essential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434. Mol Cell Endocrinol. 2013 Jun 15; 372(1-2):42-8. PMID: 23523567.
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    14. Song HW, Anderson RA, Bayne RA, Gromoll J, Shimasaki S, Chang RJ, Parast MM, Laurent LC, de Rooij DG, Hsieh TC, Wilkinson MF. The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells. Hum Reprod. 2013 Jun; 28(6):1635-46. PMID: 23482336.
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    15. Hashimoto O, Takagi R, Yanuma F, Doi S, Shindo J, Endo H, Hasegawa Y, Shimasaki S. Identification and characterization of canine growth differentiation factor-9 and its splicing variant. Gene. 2012 May 15; 499(2):266-72. PMID: 22446043.
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    16. Otsuka F, McTavish KJ, Shimasaki S. Integral role of GDF-9 and BMP-15 in ovarian function. Mol Reprod Dev. 2011 Jan; 78(1):9-21. PMID: 21226076.
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    17. Inagaki K, Shimasaki S. Impaired production of BMP-15 and GDF-9 mature proteins derived from proproteins WITH mutations in the proregion. Mol Cell Endocrinol. 2010 Oct 26; 328(1-2):1-7. PMID: 20547206.
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    18. Tibaldi E, Arrigoni G, Martinez HM, Inagaki K, Shimasaki S, Pinna LA. Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9. FEBS Lett. 2010 Feb 19; 584(4):801-5. PMID: 20067794.
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    19. Mutiara S, Kanasaki H, Oride A, Purwana IN, Shimasaki S, Yamamoto H, Miyazaki K. Follistatin gene expression by gonadotropin-releasing hormone: a role for cyclic AMP and mitogen-activated protein kinase signaling pathways in clonal gonadotroph LbetaT2 cells. Mol Cell Endocrinol. 2009 Aug 13; 307(1-2):125-32. PMID: 19533841.
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    20. McMahon HE, Hashimoto O, Mellon PL, Shimasaki S. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology. 2008 Jun; 149(6):2807-15. PMID: 18308851.
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    21. Wachs DS, Coffler MS, Malcom PJ, Shimasaki S, Chang RJ. Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008 May; 93(5):1827-33. PMID: 18285408.
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    22. Saito S, Yano K, Sharma S, McMahon HE, Shimasaki S. Characterization of the post-translational modification of recombinant human BMP-15 mature protein. Protein Sci. 2008 Feb; 17(2):362-70. PMID: 18227435.
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    23. McMahon HE, Sharma S, Shimasaki S. Phosphorylation of bone morphogenetic protein-15 and growth and differentiation factor-9 plays a critical role in determining agonistic or antagonistic functions. Endocrinology. 2008 Feb; 149(2):812-7. PMID: 18006624.
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    24. Sugiura K, Su YQ, Diaz FJ, Pangas SA, Sharma S, Wigglesworth K, O'Brien MJ, Matzuk MM, Shimasaki S, Eppig JJ. Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. Development. 2007 Jul; 134(14):2593-603. PMID: 17553902.
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    25. Lerch TF, Shimasaki S, Woodruff TK, Jardetzky TS. Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions. J Biol Chem. 2007 May 25; 282(21):15930-9. PMID: 17409095.
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    26. Shimasaki S. BMP-15 regulation of ovulation quota in mammals. Reprod Med Biol. 2006 Dec; 5(4):245-248. PMID: 29699253.
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    27. Yoshino O, McMahon HE, Sharma S, Shimasaki S. A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10678-83. PMID: 16818886.
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    28. Kihara S, Yamamoto H, Ohba T, Shimasaki S, Okamura H. Activation of follistatin promoter by GnRH in LbetaT2 gonadotroph cells. Endocr J. 2006 Apr; 53(2):225-35. PMID: 16618982.
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    29. Clelland E, Kohli G, Campbell RK, Sharma S, Shimasaki S, Peng C. Bone morphogenetic protein-15 in the zebrafish ovary: complementary deoxyribonucleic acid cloning, genomic organization, tissue distribution, and role in oocyte maturation. Endocrinology. 2006 Jan; 147(1):201-9. PMID: 16210364.
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    30. Otsuka F, Moore RK, Wang X, Sharma S, Miyoshi T, Shimasaki S. Essential role of the oocyte in estrogen amplification of follicle-stimulating hormone signaling in granulosa cells. Endocrinology. 2005 Aug; 146(8):3362-7. PMID: 15878960.
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    31. Moore RK, Shimasaki S. Molecular biology and physiological role of the oocyte factor, BMP-15. Mol Cell Endocrinol. 2005 Apr 29; 234(1-2):67-73. PMID: 15836954.
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    32. Hashimoto O, Moore RK, Shimasaki S. Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5426-31. PMID: 15809424.
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    33. Thomas FH, Ethier JF, Shimasaki S, Vanderhyden BC. Follicle-stimulating hormone regulates oocyte growth by modulation of expression of oocyte and granulosa cell factors. Endocrinology. 2005 Feb; 146(2):941-9. PMID: 15539559.
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    34. Lee WS, Yoon SJ, Yoon TK, Cha KY, Lee SH, Shimasaki S, Lee S, Lee KA. Effects of bone morphogenetic protein-7 (BMP-7) on primordial follicular growth in the mouse ovary. Mol Reprod Dev. 2004 Oct; 69(2):159-63. PMID: 15293217.
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    35. Moore RK, Erickson GF, Shimasaki S. Are BMP-15 and GDF-9 primary determinants of ovulation quota in mammals? Trends Endocrinol Metab. 2004 Oct; 15(8):356-61. PMID: 15380806.
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    36. Erickson GF, Fuqua L, Shimasaki S. Analysis of spatial and temporal expression patterns of bone morphogenetic protein family members in the rat uterus over the estrous cycle. J Endocrinol. 2004 Aug; 182(2):203-17. PMID: 15283681.
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    37. Matsui M, Sonntag B, Hwang SS, Byerly T, Hourvitz A, Adashi EY, Shimasaki S, Erickson GF. Pregnancy-associated plasma protein-a production in rat granulosa cells: stimulation by follicle-stimulating hormone and inhibition by the oocyte-derived bone morphogenetic protein-15. Endocrinology. 2004 Aug; 145(8):3686-95. PMID: 15087430.
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    38. Liao WX, Moore RK, Shimasaki S. Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9. J Biol Chem. 2004 Apr 23; 279(17):17391-6. PMID: 14970198.
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    39. Shimasaki S, Moore RK, Otsuka F, Erickson GF. The bone morphogenetic protein system in mammalian reproduction. Endocr Rev. 2004 Feb; 25(1):72-101. PMID: 14769828.
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    40. Erickson GF, Shimasaki S. The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. Reprod Biol Endocrinol. 2003 Feb 05; 1:9. PMID: 12741959.
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    41. Shimasaki S, Moore RK, Erickson GF, Otsuka F. The role of bone morphogenetic proteins in ovarian function. Reprod Suppl. 2003; 61:323-37. PMID: 14635945.
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    42. Otsuka F, Shimasaki S. A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes. Endocrinology. 2002 Dec; 143(12):4938-41. PMID: 12446622.
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    43. Liao WX, Moore RK, Otsuka F, Shimasaki S. Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep. J Biol Chem. 2003 Feb 07; 278(6):3713-9. PMID: 12446716.
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    44. Moore RK, Otsuka F, Shimasaki S. Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. J Biol Chem. 2003 Jan 03; 278(1):304-10. PMID: 12419820.
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    45. Otsuka F, Shimasaki S. A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: its role in regulating granulosa cell mitosis. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8060-5. PMID: 12048244.
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    46. Nakatani M, Yamakawa N, Matsuzaki T, Shimasaki S, Sugino H, Tsuchida K. Genomic organization and promoter analysis of mouse follistatin-related gene (FLRG). Mol Cell Endocrinol. 2002 Mar 28; 189(1-2):117-23. PMID: 12039070.
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    47. Teixeira Filho FL, Baracat EC, Lee TH, Suh CS, Matsui M, Chang RJ, Shimasaki S, Erickson GF. Aberrant expression of growth differentiation factor-9 in oocytes of women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Mar; 87(3):1337-44. PMID: 11889206.
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    48. Otsuka F, Moore RK, Iemura S, Ueno N, Shimasaki S. Follistatin inhibits the function of the oocyte-derived factor BMP-15. Biochem Biophys Res Commun. 2001 Dec 21; 289(5):961-6. PMID: 11741284.
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    49. Moore RK, Otsuka F, Shimasaki S. Role of ERK1/2 in the differential synthesis of progesterone and estradiol by granulosa cells. Biochem Biophys Res Commun. 2001 Dec 14; 289(4):796-800. PMID: 11735115.
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    50. Erickson GF, Shimasaki S. The physiology of folliculogenesis: the role of novel growth factors. Fertil Steril. 2001 Nov; 76(5):943-9. PMID: 11704115.
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    51. Lee WS, Otsuka F, Moore RK, Shimasaki S. Effect of bone morphogenetic protein-7 on folliculogenesis and ovulation in the rat. Biol Reprod. 2001 Oct; 65(4):994-9. PMID: 11566718.
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    52. Otsuka F, Moore RK, Shimasaki S. Biological function and cellular mechanism of bone morphogenetic protein-6 in the ovary. J Biol Chem. 2001 Aug 31; 276(35):32889-95. PMID: 11447221.
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    53. Otsuka F, Yamamoto S, Erickson GF, Shimasaki S. Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression. J Biol Chem. 2001 Apr 06; 276(14):11387-92. PMID: 11154695.
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    54. Otsuka F, Yao Z, Lee T, Yamamoto S, Erickson GF, Shimasaki S. Bone morphogenetic protein-15. Identification of target cells and biological functions. J Biol Chem. 2000 Dec 15; 275(50):39523-8. PMID: 10998422.
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    55. Hashimoto O, Kawasaki N, Tsuchida K, Shimasaki S, Hayakawa T, Sugino H. Difference between follistatin isoforms in the inhibition of activin signalling: activin neutralizing activity of follistatin isoforms is dependent on their affinity for activin. Cell Signal. 2000 Aug; 12(8):565-71. PMID: 11027950.
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    56. Erickson GF, Shimasaki S. The role of the oocyte in folliculogenesis. Trends Endocrinol Metab. 2000 Jul; 11(5):193-8. PMID: 10856922.
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    57. Yamamoto TS, Iemura S, Takagi C, Shimasaki S, Ueno N. Characterization of follistatin isoforms in early Xenopus embryogenesis. Int J Dev Biol. 2000 Jun; 44(4):341-8. PMID: 10949043.
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    58. Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang RJ, Erickson GF. A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7282-7. PMID: 10377406.
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    59. Iemura S, Yamamoto TS, Takagi C, Uchiyama H, Natsume T, Shimasaki S, Sugino H, Ueno N. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9337-42. PMID: 9689081.
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    60. Kubo T, Shimasaki S, Kim H, Li D, Erickson GF. Activin-induced inhibin alpha-subunit production by rat granulosa cells requires endogenous insulin-like growth factor-I. Biol Reprod. 1998 Mar; 58(3):712-8. PMID: 9510958.
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    61. Li D, Kubo T, Kim H, Shimasaki S, Erickson GF. Endogenous insulin-like growth factor-I is obligatory for stimulation of rat inhibin alpha-subunit expression by follicle-stimulating hormone. Biol Reprod. 1998 Jan; 58(1):219-25. PMID: 9472944.
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    62. Wallen LD, Myint W, Nygard K, Shimasaki S, Clemmons DR, Han VK. Cellular distribution of insulin-like growth factor binding protein mRNAs and peptides during rat lung development. J Endocrinol. 1997 Nov; 155(2):313-27. PMID: 9415066.
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    63. Piferrer F, Li D, Shimasaki S, Erickson GF. Transforming growth factor-alpha stimulates insulin-like growth factor binding protein-4 (IGFBP-4) expression and blocks follicle-stimulating hormone regulation of IGFBP-4 production in rat granulosa cells. Mol Cell Endocrinol. 1997 Sep 30; 133(1):9-17. PMID: 9359468.
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    64. Hashimoto O, Nakamura T, Shoji H, Shimasaki S, Hayashi Y, Sugino H. A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate. J Biol Chem. 1997 May 23; 272(21):13835-42. PMID: 9153241.
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    65. Han VK, Matsell DG, Delhanty PJ, Hill DJ, Shimasaki S, Nygard K. IGF-binding protein mRNAs in the human fetus: tissue and cellular distribution of developmental expression. Horm Res. 1996; 45(3-5):160-6. PMID: 8964576.
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    66. Erickson GF, Girvigian MR, Sadighian AR, Nakatani A, Ling N, Shimasaki S. Tissue specific and cyclic expression of insulin-like growth factor binding proteins-1,-2,-3,-4,-5,-6 in the rat oviduct. Endocrine. 1995 Sep; 3(9):667-76. PMID: 21153225.
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    67. Wang D, Nagpal ML, Shimasaki S, Ling N, Lin T. Interleukin-1 induces insulin-like growth factor binding protein-3 gene expression and protein production by Leydig cells. Endocrinology. 1995 Sep; 136(9):4049-55. PMID: 7544275.
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    68. Erickson GF, Chung DG, Sit A, DePaolo LV, Shimasaki S, Ling N. Follistatin concentrations in follicular fluid of normal and polycystic ovaries. Hum Reprod. 1995 Aug; 10(8):2120-4. PMID: 8567852.
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    69. Erickson GF, Li D, Shimasaki S, Ling N, Weitsman SR, Magoffin DA. Insulin-like growth factor-1 (IGF-1) stimulates the IGF binding protein system in rat theca interstitial cells. Endocrine. 1995 Jul; 3(7):525-31. PMID: 21153209.
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    70. Onoda N, Li D, Mickey G, Erickson G, Shimasaki S. Gonadotropin-releasing hormone overcomes follicle-stimulating hormone's inhibition of insulin-like growth factor-5 synthesis and promotion of its degradation in rat granulosa cells. Mol Cell Endocrinol. 1995 Apr 28; 110(1-2):17-25. PMID: 7545620.
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    71. Sumitomo S, Inouye S, Liu XJ, Ling N, Shimasaki S. The heparin binding site of follistatin is involved in its interaction with activin. Biochem Biophys Res Commun. 1995 Mar 08; 208(1):1-9. PMID: 7887917.
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    72. Girvigian MR, Nakatani A, Ling N, Shimasaki S, Erickson GF. Insulin-like growth factor binding proteins show distinct patterns of expression in the rat uterus. Biol Reprod. 1994 Aug; 51(2):296-302. PMID: 7524698.
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    73. Manni A, Badger B, Wei L, Zaenglein A, Grove R, Khin S, Heitjan D, Shimasaki S, Ling N. Hormonal regulation of insulin-like growth factor II and insulin-like growth factor binding protein expression by breast cancer cells in vivo: evidence for stromal epithelial interactions. Cancer Res. 1994 Jun 01; 54(11):2934-42. PMID: 7514495.
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    74. Hamil KG, Conti M, Shimasaki S, Hall SH. Follicle-stimulating hormone regulation of AP-1: inhibition of c-jun and stimulation of jun-B gene transcription in the rat Sertoli cell. Mol Cell Endocrinol. 1994 Mar; 99(2):269-77. PMID: 8206334.
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    75. Grimes RW, Barber JA, Shimasaki S, Ling N, Hammond JM. Porcine ovarian granulosa cells secrete insulin-like growth factor-binding proteins-4 and -5 and express their messenger ribonucleic acids: regulation by follicle-stimulating hormone and insulin-like growth factor-1. Biol Reprod. 1994 Mar; 50(3):695-701. PMID: 7513192.
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    76. Erickson GF, Li D, Sadrkhanloo R, Liu XJ, Shimasaki S, Ling N. Extrapituitary actions of gonadotropin-releasing hormone: stimulation of insulin-like growth factor-binding protein-4 and atresia. Endocrinology. 1994 Mar; 134(3):1365-72. PMID: 7509739.
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    77. Wang D, Nagpal ML, Lin T, Shimasaki S, Ling N. Insulin-like growth factor-binding protein-2: the effect of human chorionic gonadotropin on its gene regulation and protein secretion and its biological effects in rat Leydig cells. Mol Endocrinol. 1994 Jan; 8(1):69-76. PMID: 7512196.
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    78. Erickson GF, Nakatani A, Ling N, Shimasaki S. Insulin-like growth factor binding protein-3 gene expression is restricted to involuting corpora lutea in rat ovaries. Endocrinology. 1993 Sep; 133(3):1147-57. PMID: 7689948.
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    79. Sugino K, Kurosawa N, Nakamura T, Takio K, Shimasaki S, Ling N, Titani K, Sugino H. Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell. J Biol Chem. 1993 Jul 25; 268(21):15579-87. PMID: 8340384.
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    80. Miyanaga K, Erickson GF, DePaolo LV, Ling N, Shimasaki S. Differential control of activin, inhibin and follistatin proteins in cultured rat granulosa cells. Biochem Biophys Res Commun. 1993 Jul 15; 194(1):253-8. PMID: 8333840.
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    81. Lin T, Wang D, Nagpal ML, Shimasaki S, Ling N. Expression and regulation of insulin-like growth factor-binding protein-1, -2, -3, and -4 messenger ribonucleic acids in purified rat Leydig cells and their biological effects. Endocrinology. 1993 May; 132(5):1898-904. PMID: 7682935.
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    82. Mercado M, Shimasaki S, Ling N, DePaolo L. Effects of estrous cycle stage and pregnancy on follistatin gene expression and immunoreactivity in rat reproductive tissues: progesterone is implicated in regulating uterine gene expression. Endocrinology. 1993 Apr; 132(4):1774-81. PMID: 8462476.
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    83. Zhu X, Ling N, Shimasaki S. Structural characterization of the rat insulin-like growth factor binding protein-6 gene. Biochem Biophys Res Commun. 1993 Mar 31; 191(3):1237-43. PMID: 7682065.
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    84. Miyanaga K, Shimasaki S. Structural and functional characterization of the rat follistatin (activin-binding protein) gene promoter. Mol Cell Endocrinol. 1993 Mar; 92(1):99-109. PMID: 8472873.
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    85. Delhanty PJ, Hill DJ, Shimasaki S, Han VK. Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation? Growth Regul. 1993 Mar; 3(1):8-11. PMID: 7683540.
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    86. Ling NC, Liu XJ, Malkowski M, Guo YL, Erickson GF, Shimasaki S. Structural and functional studies of insulin-like growth factor binding proteins in the ovary. Growth Regul. 1993 Mar; 3(1):70-4. PMID: 7683537.
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    87. Liu XJ, Malkowski M, Guo Y, Erickson GF, Shimasaki S, Ling N. Development of specific antibodies to rat insulin-like growth factor-binding proteins (IGFBP-2 to -6): analysis of IGFBP production by rat granulosa cells. Endocrinology. 1993 Mar; 132(3):1176-83. PMID: 7679972.
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    88. Gao L, Ling N, Shimasaki S. Structure of the rat insulin-like growth factor binding protein-4 gene. Biochem Biophys Res Commun. 1993 Feb 15; 190(3):1053-9. PMID: 7679899.
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    89. Zhu X, Ling N, Shimasaki S. Cloning of the rat insulin- like growth factor binding protein-5 gene and DNA sequence analysis of its promoter region. Biochem Biophys Res Commun. 1993 Feb 15; 190(3):1045-52. PMID: 7679898.
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    90. Krywicki RF, Figueroa JA, Jackson JG, Kozelsky TW, Shimasaki S, Von Hoff DD, Yee D. Regulation of insulin-like growth factor binding proteins in ovarian cancer cells by oestrogen. Eur J Cancer. 1993; 29A(14):2015-9. PMID: 7506561.
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    91. Kaipia A, Penttilä TL, Shimasaki S, Ling N, Parvinen M, Toppari J. Expression of inhibin beta A and beta B, follistatin and activin-A receptor messenger ribonucleic acids in the rat seminiferous epithelium. Endocrinology. 1992 Dec; 131(6):2703-10. PMID: 1332846.
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    92. Inouye S, Ling N, Shimasaki S. Localization of the heparin binding site of follistatin. Mol Cell Endocrinol. 1992 Dec; 90(1):1-6. PMID: 1301390.
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    93. McGuire WL, Jackson JG, Figueroa JA, Shimasaki S, Powell DR, Yee D. Regulation of insulin-like growth factor-binding protein (IGFBP) expression by breast cancer cells: use of IGFBP-1 as an inhibitor of insulin-like growth factor action. J Natl Cancer Inst. 1992 Sep 02; 84(17):1336-41. PMID: 1379645.
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    94. Samaras SE, Hagen DR, Shimasaki S, Ling N, Hammond JM. Expression of insulin-like growth factor-binding protein-2 and -3 messenger ribonucleic acid in the porcine ovary: localization and physiological changes. Endocrinology. 1992 May; 130(5):2739-44. PMID: 1374013.
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    95. Itoh H, Shimasaki S, Nakashima A, Ohsato K, Tokikuni N, Kitajima C. Sweet's syndrome associated with subacute necrotizing lymphadenitis. Intern Med. 1992 May; 31(5):686-9. PMID: 1504437.
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    96. Grimes RW, Samaras SE, Barber JA, Shimasaki S, Ling N, Hammond JM. Gonadotropin and cAMP modulation of IGE binding protein production in ovarian granulosa cells. Am J Physiol. 1992 Apr; 262(4 Pt 1):E497-503. PMID: 1373563.
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    97. Erickson GF, Nakatani A, Ling N, Shimasaki S. Localization of insulin-like growth factor-binding protein-5 messenger ribonucleic acid in rat ovaries during the estrous cycle. Endocrinology. 1992 Apr; 130(4):1867-78. PMID: 1372237.
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    98. Manni A, Wei L, Badger B, Zaenglein A, Leighton J, Shimasaki S, Ling N. Expression of messenger RNA for insulin-like growth factors and insulin-like growth factor binding proteins by experimental breast cancer and normal breast tissue in vivo. Endocrinology. 1992 Mar; 130(3):1744-6. PMID: 1371457.
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    99. Erickson GF, Nakatani A, Ling N, Shimasaki S. Cyclic changes in insulin-like growth factor-binding protein-4 messenger ribonucleic acid in the rat ovary. Endocrinology. 1992 Feb; 130(2):625-36. PMID: 1370792.
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    100. Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S. Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):197-201. PMID: 1729689.
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    101. Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG. Conserved sequence motifs in the small subunit of human general transcription factor TFIIE. Nature. 1991 Dec 05; 354(6352):401-4. PMID: 1956404.
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    102. Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG. Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE. Nature. 1991 Dec 05; 354(6352):398-401. PMID: 1956403.
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    103. Kaipia A, Parvinen M, Shimasaki S, Ling N, Toppari J. Stage-specific cellular regulation of inhibin alpha-subunit mRNA expression in the rat seminiferous epithelium. Mol Cell Endocrinol. 1991 Dec; 82(2-3):165-73. PMID: 1794607.
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    104. DePaolo LV, Bicsak TA, Erickson GF, Shimasaki S, Ling N. Follistatin and activin: a potential intrinsic regulatory system within diverse tissues. Proc Soc Exp Biol Med. 1991 Oct; 198(1):500-12. PMID: 1909791.
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    105. Nakatani A, Shimasaki S, Erickson GF, Ling N. Tissue-specific expression of four insulin-like growth factor-binding proteins (1, 2, 3, and 4) in the rat ovary. Endocrinology. 1991 Sep; 129(3):1521-9. PMID: 1714834.
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    106. Inouye S, Guo Y, Ling N, Shimasaki S. Site-specific mutagenesis of human follistatin. Biochem Biophys Res Commun. 1991 Aug 30; 179(1):352-8. PMID: 1883364.
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    107. Inouye S, Guo Y, DePaolo L, Shimonaka M, Ling N, Shimasaki S. Recombinant expression of human follistatin with 315 and 288 amino acids: chemical and biological comparison with native porcine follistatin. Endocrinology. 1991 Aug; 129(2):815-22. PMID: 1906804.
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    108. Nakatani A, Shimasaki S, Depaolo LV, Erickson GF, Ling N. Cyclic changes in follistatin messenger ribonucleic acid and its protein in the rat ovary during the estrous cycle. Endocrinology. 1991 Aug; 129(2):603-11. PMID: 1855461.
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    109. Cheung PT, Smith EP, Shimasaki S, Ling N, Chernausek SD. Characterization of an insulin-like growth factor binding protein (IGFBP-4) produced by the B104 rat neuronal cell line: chemical and biological properties and differential synthesis by sublines. Endocrinology. 1991 Aug; 129(2):1006-15. PMID: 1713156.
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    110. Shimasaki S, Gao L, Shimonaka M, Ling N. Isolation and molecular cloning of insulin-like growth factor-binding protein-6. Mol Endocrinol. 1991 Jul; 5(7):938-48. PMID: 1719383.
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    111. Shimasaki S, Shimonaka M, Zhang HP, Ling N. Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. J Biol Chem. 1991 Jun 05; 266(16):10646-53. PMID: 1709938.
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    112. Shimonaka M, Inouye S, Shimasaki S, Ling N. Follistatin binds to both activin and inhibin through the common subunit. Endocrinology. 1991 Jun; 128(6):3313-5. PMID: 2036994.
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    113. Whiting PJ, Schoepfer R, Conroy WG, Gore MJ, Keyser KT, Shimasaki S, Esch F, Lindstrom JM. Expression of nicotinic acetylcholine receptor subtypes in brain and retina. Brain Res Mol Brain Res. 1991 Apr; 10(1):61-70. PMID: 1647484.
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    114. Shimasaki S, Ling N. Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6). Prog Growth Factor Res. 1991; 3(4):243-66. PMID: 1725860.
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    115. Shimasaki S, Uchiyama F, Shimonaka M, Ling N. Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. Mol Endocrinol. 1990 Oct; 4(10):1451-8. PMID: 1704481.
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    116. Ling N, DePaolo LV, Bicsak TA, Shimasaki S. Novel ovarian regulatory peptides: inhibin, activin, and follistatin. Clin Obstet Gynecol. 1990 Sep; 33(3):690-702. PMID: 2121404.
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    117. Shimasaki S, Shimonaka M, Ui M, Inouye S, Shibata F, Ling N. Structural characterization of a follicle-stimulating hormone action inhibitor in porcine ovarian follicular fluid. Its identification as the insulin-like growth factor-binding protein. J Biol Chem. 1990 Feb 05; 265(4):2198-202. PMID: 1688850.
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    118. Klaij IA, Toebosch AM, Themmen AP, Shimasaki S, de Jong FH, Grootegoed JA. Regulation of inhibin alpha- and beta B-subunit mRNA levels in rat Sertoli cells. Mol Cell Endocrinol. 1990 Jan 02; 68(1):45-52. PMID: 2154391.
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    119. Shimasaki S, Koba A, Mercado M, Shimonaka M, Ling N. Complementary DNA structure of the high molecular weight rat insulin-like growth factor binding protein (IGF-BP3) and tissue distribution of its mRNA. Biochem Biophys Res Commun. 1989 Dec 15; 165(2):907-12. PMID: 2480787.
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    120. Wada K, Dechesne CJ, Shimasaki S, King RG, Kusano K, Buonanno A, Hampson DR, Banner C, Wenthold RJ, Nakatani Y. Sequence and expression of a frog brain complementary DNA encoding a kainate-binding protein. Nature. 1989 Dec 07; 342(6250):684-9. PMID: 2556640.
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    121. Shimonaka M, Schroeder R, Shimasaki S, Ling N. Identification of a novel binding protein for insulin-like growth factors in adult rat serum. Biochem Biophys Res Commun. 1989 Nov 30; 165(1):189-95. PMID: 2480123.
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    122. Turner IM, Saunders PT, Shimasaki S, Hillier SG. Regulation of inhibin subunit gene expression by FSH and estradiol in cultured rat granulosa cells. Endocrinology. 1989 Nov; 125(5):2790-2. PMID: 2507299.
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    123. Hillier SG, Wickings EJ, Saunders PT, Dixson AF, Shimasaki S, Swanston IA, Reichert LE, McNeilly AS. Control of inhibin production by primate granulosa cells. J Endocrinol. 1989 Oct; 123(1):65-73. PMID: 2509620.
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    124. Krummen LA, Toppari J, Kim WH, Morelos BS, Ahmad N, Swerdloff RS, Ling N, Shimasaki S, Esch F, Bhasin S. Regulation of testicular inhibin subunit messenger ribonucleic acid levels in vivo: effects of hypophysectomy and selective follicle-stimulating hormone replacement. Endocrinology. 1989 Sep; 125(3):1630-7. PMID: 2503372.
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    125. Ui M, Shimonaka M, Shimasaki S, Ling N. An insulin-like growth factor-binding protein in ovarian follicular fluid blocks follicle-stimulating hormone-stimulated steroid production by ovarian granulosa cells. Endocrinology. 1989 Aug; 125(2):912-6. PMID: 2473892.
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    126. Shimasaki S, Koga M, Buscaglia ML, Simmons DM, Bicsak TA, Ling N. Follistatin gene expression in the ovary and extragonadal tissues. Mol Endocrinol. 1989 Apr; 3(4):651-9. PMID: 2725528.
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    127. Bhasin S, Krummen LA, Swerdloff RS, Morelos BS, Kim WH, diZerega GS, Ling N, Esch F, Shimasaki S, Toppari J. Stage dependent expression of inhibin alpha and beta-B subunits during the cycle of the rat seminiferous epithelium. Endocrinology. 1989 Feb; 124(2):987-91. PMID: 2912710.
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    128. Emoto N, Gonzalez AM, Walicke PA, Wada E, Simmons DM, Shimasaki S, Baird A. Basic fibroblast growth factor (FGF) in the central nervous system: identification of specific loci of basic FGF expression in the rat brain. Growth Factors. 1989; 2(1):21-9. PMID: 2635054.
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    129. Shimasaki S, Emoto N, Koba A, Mercado M, Shibata F, Cooksey K, Baird A, Ling N. Complementary DNA cloning and sequencing of rat ovarian basic fibroblast growth factor and tissue distribution study of its mRNA. Biochem Biophys Res Commun. 1988 Nov 30; 157(1):256-63. PMID: 3196337.
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    130. Singh A, Bateman A, Zhu QZ, Shimasaki S, Esch F, Solomon S. Structure of a novel human granulocyte peptide with anti-ACTH activity. Biochem Biophys Res Commun. 1988 Aug 30; 155(1):524-9. PMID: 2843187.
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    131. Shimasaki S, Koga M, Esch F, Cooksey K, Mercado M, Koba A, Ueno N, Ying SY, Ling N, Guillemin R. Primary structure of the human follistatin precursor and its genomic organization. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4218-22. PMID: 3380788.
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    132. Schoepfer R, Whiting P, Esch F, Blacher R, Shimasaki S, Lindstrom J. cDNA clones coding for the structural subunit of a chicken brain nicotinic acetylcholine receptor. Neuron. 1988 May; 1(3):241-8. PMID: 3272170.
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    133. Shimasaki S, Koga M, Esch F, Mercado M, Cooksey K, Koba A, Ling N. Porcine follistatin gene structure supports two forms of mature follistatin produced by alternative splicing. Biochem Biophys Res Commun. 1988 Apr 29; 152(2):717-23. PMID: 3365249.
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    134. Ling N, Ueno N, Ying SY, Esch F, Shimasaki S, Hotta M, Cuevas P, Guillemin R. Inhibins and activins. Vitam Horm. 1988; 44:1-46. PMID: 3070928.
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    135. Zhu QZ, Hu J, Mulay S, Esch F, Shimasaki S, Solomon S. Isolation and structure of corticostatin peptides from rabbit fetal and adult lung. Proc Natl Acad Sci U S A. 1988 Jan; 85(2):592-6. PMID: 2829194.
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    136. Ueno N, Ling N, Ying SY, Esch F, Shimasaki S, Guillemin R. Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8282-6. PMID: 3120188.
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    137. Ying SY, Becker A, Swanson G, Tan P, Ling N, Esch F, Ueno N, Shimasaki S, Guillemin R. Follistatin specifically inhibits pituitary follicle stimulating hormone release in vitro. Biochem Biophys Res Commun. 1987 Nov 30; 149(1):133-9. PMID: 3120723.
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    138. Esch FS, Shimasaki S, Mercado M, Cooksey K, Ling N, Ying S, Ueno N, Guillemin R. Structural characterization of follistatin: a novel follicle-stimulating hormone release-inhibiting polypeptide from the gonad. Mol Endocrinol. 1987 Nov; 1(11):849-55. PMID: 3153465.
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    139. Fisher LW, Robey PG, Tuross N, Otsuka AS, Tepen DA, Esch FS, Shimasaki S, Termine JD. The Mr 24,000 phosphoprotein from developing bone is the NH2-terminal propeptide of the alpha 1 chain of type I collagen. J Biol Chem. 1987 Oct 05; 262(28):13457-63. PMID: 3654622.
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    140. Whiting P, Esch F, Shimasaki S, Lindstrom J. Neuronal nicotinic acetylcholine receptor beta-subunit is coded for by the cDNA clone alpha 4. FEBS Lett. 1987 Jul 27; 219(2):459-63. PMID: 3609304.
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    141. Esch FS, Shimasaki S, Cooksey K, Mercado M, Mason AJ, Ying SY, Ueno N, Ling N. Complementary deoxyribonucleic acid (cDNA) cloning and DNA sequence analysis of rat ovarian inhibins. Mol Endocrinol. 1987 May; 1(5):388-96. PMID: 2484214.
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    142. Story MT, Esch F, Shimasaki S, Sasse J, Jacobs SC, Lawson RK. Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue. Biochem Biophys Res Commun. 1987 Feb 13; 142(3):702-9. PMID: 2435284.
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    143. Ueno N, Baird A, Esch F, Shimasaki S, Ling N, Guillemin R. Purification and partial characterization of a mitogenic factor from bovine liver: structural homology with basic fibroblast growth factor. Regul Pept. 1986 Dec 22; 16(2):135-45. PMID: 3809608.
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    144. Esch FS, Mason AJ, Cooksey K, Mercado M, Shimasaki S. Cloning and DNA sequence analysis of the cDNA for the precursor of the beta chain of bovine follicle stimulating hormone. Proc Natl Acad Sci U S A. 1986 Sep; 83(17):6618-21. PMID: 3092216.
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    145. Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R. A homodimer of the beta-subunits of inhibin A stimulates the secretion of pituitary follicle stimulating hormone. Biochem Biophys Res Commun. 1986 Aug 14; 138(3):1129-37. PMID: 3092817.
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    146. Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R. Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin. Nature. 1986 Jun 19-25; 321(6072):779-82. PMID: 3086749.
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    147. Shimasaki S, Iuchi I. Diversity of human gamma-globin gene loci including a quadruplicated arrangement. Blood. 1986 Mar; 67(3):784-8. PMID: 3947746.
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    148. Hidaka K, Iuchi I, Shimasaki S, Mizuta W, Takatsuka M, Mori T, Tohdoh A, Matsuo M. The survey of abnormal hemoglobins in the Kobe district: Hb G-Coushatta [beta 22(B4)Glu----Ala], Hb Ankara (beta 10(A7)Ala----Asp], Hb Handa [alpha 90(FG2)Lys----Met], and Hb J-Habana [alpha 71(E20)Ala----Glu]. Hemoglobin. 1986; 10(1):65-72. PMID: 3957691.
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    149. Shimasaki S. A new hemoglobin variant, hemoglobin Nunobiki [alpha 141 (HC3) Arg----Cys]. Notable influence of the carboxy-terminal cysteine upon various physico-chemical characteristics of hemoglobin. J Clin Invest. 1985 Feb; 75(2):695-701. PMID: 3973024.
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    150. Iuchi I, Shimasaki S, Hidaka K, Mizuta W. Hb Albany-Suma (alpha 11 [A9] Lys----Asn), a hemoglobin variant with slightly elevated oxygen affinity in Japan. Hemoglobin. 1984; 8(4):343-51. PMID: 6434493.
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    151. Iuchi I, Hidaka K, Shimasaki S, Shibata S, Ueda S, Mizushima M, Aoba H. Abnormal hemoglobins in the Takamatsu district with emphasis on epidemiological characteristics. Hemoglobin. 1982; 6(5):493-502. PMID: 7174348.
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    152. Iuchi I, Shimasaki S, Hidaka K, Ueda S, Shibata S, Mizushima J, Harada H. Hb Ube-2 (alpha 68[e-17]Asn replaced by Asp): the second instance in Japan. Hemoglobin. 1981; 5(6):599-603. PMID: 7319829.
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    153. Iuchi I, Shimasaki S, Hidaka K, Ueda S, Harano T, Shibata S, Mizushima J, Ohnishi Y. Hemoglobin J Bangkok (beta 56[D7]Gly leads to Asp): a hemoglobin variant discovered by the hemoglobinopathy survey in Takamatsu district. Hemoglobin. 1981; 5(2):199-204. PMID: 7216820.
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    154. Iuchi I, Shimasaki S, Hidaka K, Harano T, Ueda S, Shibata S, Mizushima J, Kubo N. Hemoglobin Mizushi (alpha 75 [EF4]Asp leads to Gly): a new hemoglobin variant observed in a Japanese family. Hemoglobin. 1980; 4(2):209-14. PMID: 7390865.
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    155. Iuchi I, Hidaka K, Harano T, Ueda S, Shibata S, Shimasaki S, Mizushima J, Kubo N, Miyake T, Uchida T. Hemoglobin takamatsu (beta 120 (GH 3) Lys leads to Gln): a new abnormal hemoglobin detected in three unrelated families in the takamatsu area of shikoku. Hemoglobin. 1980; 4(2):165-76. PMID: 7390862.
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