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Tomoko Hayashi

Title(s)Recall Non-faculty Academic, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy. Commun Med (Lond). 2025 Aug 29; 5(1):378. Niimura M, Sakamoto Y, Shimoda M, Harada N, Maeda A, Wada S, Murata K, Thinyakul C, Liu S, Ohara H, Iwamoto A, Kanamori Y, Nita A, Wakao M, Suda Y, Oshiumi H, Hayashi T, Carson DA, Shinchi H, Moroishi T. PMID: 40883594; PMCID: PMC12397435.
      View in: PubMed   Mentions:
    2. Design and Application of Conjugatable Small Molecule Toll-Like Receptor 4 Ligands. Bioconjug Chem. 2025 Jul 16; 36(7):1409-1420. Mahara Y, Fukuda I, Tanaka R, Oyama SY, Shinchi H, Suda Y, Shukla NM, Chan M, Hayashi T, Cottam HB, Carson DA, Wakao M. PMID: 40533421.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Effectiveness of the Facility for Elderly Surveillance System (FESSy) in Two Public Health Center Jurisdictions in Japan: Prospective Observational Study. JMIR Med Inform. 2025 Jan 10; 13:e58509. Kurita J, Hori M, Yamaguchi S, Ogiwara A, Saito Y, Sugiyama M, Sunadori A, Hayashi T, Hara A, Kawana Y, Itoi Y, Sugawara T, Sugishita Y, Irie F, Sakurai N. PMID: 39803892; PMCID: PMC11741194.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    4. In Vivo Bioluminescence Imaging of Tumor Progression in the Lewis Lung Carcinoma Orthotopic Mouse Model: A Comparison Between the Tail Vein Injection and Intranasal Instillation Methods. Curr Protoc. 2024 Dec; 4(12):e70071. Yamada-Hara M, Takahashi N, Byun JW, Zeng L, Wang Z, Tanaka A, Malakoutikhah Z, Hayashi T, Webster NJG, Raz E, Bertin S. PMID: 39660610; PMCID: PMC11649249.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Structure-Activity Relationship Studies in Benzothiadiazoles as Novel Vaccine Adjuvants. J Med Chem. 2024 08 22; 67(16):13703-13722. Belsuzarri MM, Sako Y, Brown TD, Chan M, Cozza R, Jin J, Sato-Kaneko F, Yao S, Pu M, Messer K, Hayashi T, Cottam HB, Corr M, Carson DA, Shukla NM. PMID: 39115891.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses. Pharmaceutics. 2024 Jan 13; 16(1). Abdelwahab WM, Auclair S, Borgogna T, Siram K, Riffey A, Bazin HG, Cottam HB, Hayashi T, Evans JT, Burkhart DJ. PMID: 38258117; PMCID: PMC10819884.
      View in: PubMed   Mentions: 4  
    7. Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx. ACS Chem Biol. 2023 04 21; 18(4):982-993. Sako Y, Sato-Kaneko F, Shukla NM, Yao S, Belsuzarri MM, Chan M, Saito T, Lao FS, Kong H, Puffer M, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T. PMID: 37039433; PMCID: PMC10127211.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    8. Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model. J Immunother Cancer. 2023 01; 11(1). Shankara Narayanan JS, Hayashi T, Erdem S, McArdle S, Tiriac H, Ray P, Pu M, Mikulski Z, Miller A, Messer K, Carson D, Schoenberger S, White RR. PMID: 36634919; PMCID: PMC9843215.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    9. A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination. Vaccines (Basel). 2022 Oct 11; 10(10). Sato-Kaneko F, Yao S, Lao FS, Sako Y, Jin J, Shukla NM, Cottam HB, Chan M, Belsuzarri MM, Carson DA, Hayashi T. PMID: 36298559; PMCID: PMC9611830.
      View in: PubMed   Mentions: 2  
    10. A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity. Front Pharmacol. 2022; 13:869649. Shukla NM, Sato-Kaneko F, Yao S, Pu M, Chan M, Lao FS, Sako Y, Saito T, Messer K, Hayashi T, Cottam HB, Corr M, Carson DA. PMID: 35479316; PMCID: PMC9035538.
      View in: PubMed   Mentions: 3  
    11. Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects. ACS Chem Biol. 2022 04 15; 17(4):957-968. Shinchi H, Komaki F, Yuki M, Ohara H, Hayakawa N, Wakao M, Cottam HB, Hayashi T, Carson DA, Moroishi T, Suda Y. PMID: 35353497.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsPHPublic Health
    12. Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity. ACS Chem Biol. 2022 01 21; 17(1):217-229. Saito T, Shukla NM, Sato-Kaneko F, Sako Y, Hosoya T, Yao S, Lao FS, Messer K, Pu M, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34985883; PMCID: PMC8788586.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge. Front Immunol. 2021; 12:701445. Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34650551; PMCID: PMC8505803.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Sato-Kaneko F, Yao S, Lao FS, Nan J, Shpigelman J, Cheng A, Saito T, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Molina AJ, Corr M, Hayashi T, Carson DA. PMID: 34078669; PMCID: PMC8201894.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation. Bioorg Med Chem. 2021 08 01; 43:116242. Shukla NM, Chan M, Lao FS, Chu PJ, Belsuzarri M, Yao S, Nan J, Sato-Kaneko F, Saito T, Hayashi T, Corr M, Carson DA, Cottam HB. PMID: 34274759; PMCID: PMC8992012.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release. Front Pharmacol. 2021; 12:668609. Shpigelman J, Lao FS, Yao S, Li C, Saito T, Sato-Kaneko F, Nolan JP, Shukla NM, Pu M, Messer K, Cottam HB, Carson DA, Corr M, Hayashi T. PMID: 33935791; PMCID: PMC8085554.
      View in: PubMed   Mentions: 15  
    17. Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities. ACS Appl Bio Mater. 2021 03 15; 4(3):2732-2741. Shinchi H, Yuki M, Yamauchi T, Niimura M, Wakao M, Cottam HB, Hayashi T, Carson DA, Moroishi T, Suda Y. PMID: 35014312.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    18. Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Wang Q, Kim SY, Matsushita H, Wang Z, Pandyarajan V, Matsuda M, Ohashi K, Tsuchiya T, Roh YS, Kiani C, Zhao Y, Chan M, Devkota S, Lu SC, Hayashi T, Carson DA, Seki E. PMID: 33443222; PMCID: PMC7817133.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    19. Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Front Pharmacol. 2020; 11:607713. Hosoya T, Shukla NM, Fujita Y, Yao S, Lao FS, Baba H, Yasuda S, Cottam HB, Carson DA, Hayashi T, Corr M. PMID: 33390996; PMCID: PMC7773657.
      View in: PubMed   Mentions: 1  
    20. A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity. Front Immunol. 2020; 11:1207. Sato-Kaneko F, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Chu PJ, Burkhart D, Schoener R, Matsutani T, Carson DA, Corr M, Hayashi T. PMID: 32636840; PMCID: PMC7318308.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. Immunostimulatory TLR7 agonist-nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Adv Ther (Weinh). 2020 Jun; 3(6). Huang CH, Mendez N, Echeagaray OH, Weeks J, Wang J, Yao S, Blair SL, Gude N, Trogler WC, Carson DA, Hayashi T, Kummel AC. PMID: 33644299; PMCID: PMC7904104.
      View in: PubMed   Mentions: 9  
    22. Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands. Bioorg Med Chem Lett. 2020 02 01; 30(3):126840. Baba A, Wakao M, Shinchi H, Chan M, Hayashi T, Yao S, Cottam HB, Carson DA, Suda Y. PMID: 31864800.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 12; 8(23):e1901105. Battistella C, Callmann CE, Thompson MP, Yao S, Yeldandi AV, Hayashi T, Carson DA, Gianneschi NC. PMID: 31664791.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    24. Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli. J Med Chem. 2019 11 14; 62(21):9521-9540. Chan M, Lao FS, Chu PJ, Shpigelman J, Yao S, Nan J, Sato-Kaneko F, Li V, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 31603681; PMCID: PMC8992017.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α-Mannose as Adjuvants. Bioconjug Chem. 2019 11 20; 30(11):2811-2821. Shinchi H, Yamaguchi T, Moroishi T, Yuki M, Wakao M, Cottam HB, Hayashi T, Carson DA, Suda Y. PMID: 31560198.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    26. Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model. Cancer Immunol Res. 2019 10; 7(10):1714-1726. Narayanan JSS, Ray P, Hayashi T, Whisenant TC, Vicente D, Carson DA, Miller AM, Schoenberger SP, White RR. PMID: 31409607; PMCID: PMC6774877.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    27. Conjugation of a Small-Molecule TLR7 Agonist to Silica Nanoshells Enhances Adjuvant Activity. ACS Appl Mater Interfaces. 2019 Jul 31; 11(30):26637-26647. Huang CH, Mendez N, Echeagaray OH, Weeks J, Wang J, Vallez CN, Gude N, Trogler WC, Carson DA, Hayashi T, Kummel AC. PMID: 31276378.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    28. Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators. ACS Med Chem Lett. 2018 Dec 13; 9(12):1156-1159. Shukla NM, Chan M, Hayashi T, Carson DA, Cottam HB. PMID: 30613317; PMCID: PMC6295859.
      View in: PubMed   Mentions: 7  
    29. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. Biomed Res Int. 2018; 2018:8091283. Sato-Kaneko F, Wang X, Yao S, Hosoya T, Lao FS, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Carson DA, Corr M, Hayashi T. PMID: 30406141; PMCID: PMC6199861.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    30. Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6836-E6844. Hosoya T, Sato-Kaneko F, Ahmadi A, Yao S, Lao F, Kitaura K, Matsutani T, Carson DA, Hayashi T. PMID: 29967183; PMCID: PMC6055176.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    31. Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. SLAS Discov. 2018 10; 23(9):960-973. Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M. PMID: 29751735; PMCID: PMC6697428.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands. J Med Chem. 2017 11 22; 60(22):9142-9161. Chan M, Kakitsubata Y, Hayashi T, Ahmadi A, Yao S, Shukla NM, Oyama SY, Baba A, Nguyen B, Corr M, Suda Y, Carson DA, Cottam HB, Wakao M. PMID: 29049886; PMCID: PMC5940354.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    33. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 09 21; 2(18). Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE. PMID: 28931759; PMCID: PMC5621908.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    34. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice. J Virol. 2017 10 01; 91(19). Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M. PMID: 28724768; PMCID: PMC5599744.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    35. Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity. ACS Comb Sci. 2017 08 14; 19(8):533-543. Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 28657707; PMCID: PMC5841913.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    36. Cell-penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury. Nanomedicine. 2017 Aug; 13(6):1925-1932. Griffin JI, Cheng SKK, Hayashi T, Carson D, Saraswathy M, Nair DP, Simberg D. PMID: 28428051; PMCID: PMC5618708.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    37. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL. PMID: 27912060; PMCID: PMC5512418.
      View in: PubMed   Mentions: 243     Fields:    Translation:AnimalsCells
    38. Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study. J Anesth. 2016 Feb; 30(1):166-9. Hayashi T, Higuchi H, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T. PMID: 26272251.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19; 26(8):1713-23. Shinchi H, Crain B, Yao S, Chan M, Zhang SS, Ahmadiiveli A, Suda Y, Hayashi T, Cottam HB, Carson DA. PMID: 26193334.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    40. Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes. PLoS One. 2015; 10(6):e0129867. Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam HB, Carson DA, Corr M. PMID: 26076454; PMCID: PMC4468074.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    41. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015 Mar; 89(6):3221-35. Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA. PMID: 25568203; PMCID: PMC4337541.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    42. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 25288184; PMCID: PMC4250372.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    43. TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant. J Transl Med. 2014 Aug 14; 12:211. Saenz R, Futalan D, Leutenez L, Eekhout F, Fecteau JF, Sundelius S, Sundqvist S, Larsson M, Hayashi T, Minev B, Carson D, Esener S, Messmer B, Messmer D. PMID: 25123824; PMCID: PMC4261565.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    44. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014 Aug; 350(2):330-40. Hayashi T, Crain B, Yao S, Caneda CD, Cottam HB, Chan M, Corr M, Carson DA. PMID: 24893985; PMCID: PMC4109491.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    45. Fluorescent-tilmanocept for tumor margin analysis in the mouse model. J Surg Res. 2014 Aug; 190(2):528-34. Hosseini A, Baker JL, Tokin CA, Qin Z, Hall DJ, Stupak DG, Hayashi T, Wallace AM, Vera DR. PMID: 24923630; PMCID: PMC4201840.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    46. Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand. J Innate Immun. 2014; 6(3):315-24. Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T. PMID: 24192551; PMCID: PMC3972367.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    47. Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. Eur J Dermatol. 2013 Sep-Oct; 23(5):618-28. Crain B, Yao S, Keophilaone V, Promessi V, Kang M, Barberis A, Maj R, Mura E, Passini N, Holldack J, Ochoa R, Cottam HB, Carson DA, Hayashi T. PMID: 24225049; PMCID: PMC3959874.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    48. Extraction protocol and mass spectrometry method for quantification of doxorubicin released locally from prodrugs in tumor tissue. J Mass Spectrom. 2013 Jul; 48(7):768-73. Ibsen S, Su Y, Norton J, Zahavy E, Hayashi T, Adams S, Wrasidlo W, Esener S. PMID: 23832932; PMCID: PMC4110111.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    49. Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation. PLoS One. 2013; 8(6):e67258. Fang DD, Zhang CC, Gu Y, Jani JP, Cao J, Tsaparikos K, Yuan J, Thiel M, Jackson-Fisher A, Zong Q, Lappin PB, Hayashi T, Schwab RB, Wong A, John-Baptiste A, Bagrodia S, Los G, Bender S, Christensen J, Vanarsdale T. PMID: 23826249; PMCID: PMC3695076.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    50. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 23656327; PMCID: PMC3722616.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    51. Localized in vivo activation of a photoactivatable doxorubicin prodrug in deep tumor tissue. Photochem Photobiol. 2013 May-Jun; 89(3):698-708. Ibsen S, Zahavy E, Wrasidlo W, Hayashi T, Norton J, Su Y, Adams S, Esener S. PMID: 23311544; PMCID: PMC4072807.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    52. Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. PLoS One. 2012; 7(9):e45860. Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam HB, Carson DA, Corr M. PMID: 23029281; PMCID: PMC3461028.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    53. Increased aldehyde dehydrogenase activity in high-risk chronic lymphocytic leukemia. Leuk Lymphoma. 2013 Feb; 54(2):400-2. Wu RP, Li H, Rassenti LZ, Hayashi T, Wu CN, Kipps TJ, Messer K, Carson DA. PMID: 22784365; PMCID: PMC3821178.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    54. Analysis of high-throughput screening assays using cluster enrichment. Stat Med. 2012 Dec 30; 31(30):4175-89. Pu M, Hayashi T, Cottam H, Mulvaney J, Arkin M, Corr M, Carson D, Messer K. PMID: 22763983; PMCID: PMC3635947.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    55. Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1. J Immunol. 2012 Apr 01; 188(7):2977-80. Norton JT, Hayashi T, Crain B, Cho JS, Miller LS, Corr M, Carson DA. PMID: 22387558; PMCID: PMC3311728.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    56. Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand. Mediators Inflamm. 2012; 2012:262394. Hayashi T, Yao S, Crain B, Chan M, Cottam HB, Lao F, Carson DA, Corr M. PMID: 22619481; PMCID: PMC3348532.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    57. Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections. J Innate Immun. 2012; 4(2):213-8. Zinkernagel AS, Hruz P, Uchiyama S, von Köckritz-Blickwede M, Schuepbach RA, Hayashi T, Carson DA, Nizet V. PMID: 21860217; PMCID: PMC3388268.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    58. Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11163-8. Norton JT, Hayashi T, Crain B, Corr M, Carson DA. PMID: 21690387; PMCID: PMC3131380.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    59. The Role of Plasmacytoid and Myeloid Dendritic Cells in Induction of Asthma in a Mouse Model and the Effect of a TLR9 Agonist on Dendritic Cells. Allergy Asthma Immunol Res. 2011 Jul; 3(3):199-204. Mo JH, Chung YJ, Hayashi T, Lee J, Raz E. PMID: 21738886; PMCID: PMC3121062.
      View in: PubMed   Mentions: 6  
    60. Synthesis and characterization of PEGylated toll like receptor 7 ligands. Bioconjug Chem. 2011 Mar 16; 22(3):445-54. Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, Tawatao RI, Kalenian K, Zhang Y, Hayashi Y, Lao FS, Cottam HB, Carson DA. PMID: 21338093; PMCID: PMC3063487.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    61. Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2. Melanoma Res. 2011 Feb; 21(1):66-75. Hayashi T, Chan M, Norton JT, Wu CC, Yao S, Cottam HB, Tawatao RI, Corr M, Carson DA, Daniels GA. PMID: 21030882; PMCID: PMC3057341.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    62. Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7479-84. Wu RP, Hayashi T, Cottam HB, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab RB, Carson DA. PMID: 20368435; PMCID: PMC2867719.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    63. Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. Int J Urol. 2010 May; 17(5):483-90. Hayashi T, Crain B, Corr M, Chan M, Cottam HB, Maj R, Barberis A, Leoni L, Carson DA. PMID: 20337728; PMCID: PMC3876967.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    64. Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem. 2009 Jun; 20(6):1194-200. Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, Corr M, Wrasidlo W, Cottam HB, Carson DA. PMID: 19445505; PMCID: PMC2976567.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    65. Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2764-9. Hayashi T, Gray CS, Chan M, Tawatao RI, Ronacher L, McGargill MA, Datta SK, Carson DA, Corr M. PMID: 19188597; PMCID: PMC2634806.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    66. In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell Immunol. 2008 Feb; 251(2):78-85. Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M. PMID: 18495099; PMCID: PMC4012540.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    67. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R123-32. Hayashi T, Cottam HB, Chan M, Jin G, Tawatao RI, Crain B, Ronacher L, Messer K, Carson DA, Corr M. PMID: 18480244; PMCID: PMC2494819.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    68. Retraction. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2008 May; 28(5):724. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. PMID: 18504811.
      View in: PubMed   Mentions:    Fields:    
    69. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18619-24. Hayashi T, Mo JH, Gong X, Rossetto C, Jang A, Beck L, Elliott GI, Kufareva I, Abagyan R, Broide DH, Lee J, Raz E. PMID: 18003900; PMCID: PMC2141826.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    70. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3990-5. Wu CC, Hayashi T, Takabayashi K, Sabet M, Smee DF, Guiney DD, Cottam HB, Carson DA. PMID: 17360465; PMCID: PMC1820696.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    71. Functional relationships between Rad18 and WRNIP1 in vertebrate cells. Biol Pharm Bull. 2006 Nov; 29(11):2192-6. Yoshimura A, Seki M, Hayashi T, Kusa Y, Tada S, Ishii Y, Enomoto T. PMID: 17077513.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    72. TLR9-based immunotherapy for allergic disease. Am J Med. 2006 Oct; 119(10):897.e1-6. Hayashi T, Raz E. PMID: 17000223.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    73. Analyses of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in the cell. DNA Repair (Amst). 2006 Jul 13; 5(7):816-28. Kawabe Y, Seki M, Yoshimura A, Nishino K, Hayashi T, Takeuchi T, Iguchi S, Kusa Y, Ohtsuki M, Tsuyama T, Imamura O, Matsumoto T, Furuichi Y, Tada S, Enomoto T. PMID: 16769258.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    74. Vaccination with irradiated Listeria induces protective T cell immunity. Immunity. 2006 Jul; 25(1):143-52. Datta SK, Okamoto S, Hayashi T, Shin SS, Mihajlov I, Fermin A, Guiney DG, Fierer J, Raz E. PMID: 16860763.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCellsPHPublic Health
    75. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2006 Apr; 24(4):475-87. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. PMID: 16618605.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    76. CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages. FEMS Immunol Med Microbiol. 2005 Aug 01; 45(2):303-10. Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney DG. PMID: 16002269.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    77. Induction and inhibition of the Th2 phenotype spread: implications for childhood asthma. J Immunol. 2005 May 01; 174(9):5864-73. Hayashi T, Gong X, Rossetto C, Shen C, Takabayashi K, Redecke V, Spiegelberg H, Broide D, Raz E. PMID: 15843591.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    78. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 2004 Jul; 114(2):270-9. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide DH, Carson DA, Raz E. PMID: 15254594; PMCID: PMC449749.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    79. Airway peptidoglycan and immunostimulatory DNA exposures have divergent effects on the development of airway allergen hypersensitivities. J Allergy Clin Immunol. 2004 Mar; 113(3):448-54. Chisholm D, Libet L, Hayashi T, Horner AA. PMID: 15007346.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCellsPHPublic Health
    80. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology. 2004 Feb; 126(2):520-8. Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, Akira S, Takeda K, Lee J, Takabayashi K, Raz E. PMID: 14762789.
      View in: PubMed   Mentions: 266     Fields:    Translation:AnimalsCells
    81. Liposomal immunostimulatory DNA sequence (ISS-ODN): an efficient parenteral and mucosal adjuvant for influenza and hepatitis B vaccines. Vaccine. 2002 Sep 10; 20(27-28):3342-54. Joseph A, Louria-Hayon I, Plis-Finarov A, Zeira E, Zakay-Rones Z, Raz E, Hayashi T, Takabayashi K, Barenholz Y, Kedar E. PMID: 12213404.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    82. Identification of a chemotactic, MCP-1-like protein from Mycobacterium avium. FEMS Immunol Med Microbiol. 2002 Jun 03; 33(2):115-24. Rao SP, Hayashi T, Catanzaro A. PMID: 12052566.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    83. IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines. J Immunol. 2002 May 15; 168(10):4907-13. Cho HJ, Hayashi T, Datta SK, Takabayashi K, Van Uden JH, Horner A, Corr M, Raz E. PMID: 11994440.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    84. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology. 2002 May; 122(5):1428-41. Rachmilewitz D, Karmeli F, Takabayashi K, Hayashi T, Leider-Trejo L, Lee J, Leoni LM, Raz E. PMID: 11984528.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
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